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Page last updated: 2024-10-19

melatonin and Carotid Stenosis

melatonin has been researched along with Carotid Stenosis in 3 studies

Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)

Research Excerpts

Excerpt	Relevance	Reference
"Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, and neuroprotective properties."	2.72	Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis. ( Di, X; Liu, C; Ma, B; Ni, L; Niu, S; Rong, Z; Zhang, R, 2021)
" At the end of BCCAO, melatonin highest dosage caused order 2 arteriole diameter reduction by 4."	1.37	Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion. ( Cardaci, E; Colantuoni, A; Lapi, D; Paterni, M; Vagnani, S, 2011)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Zhang, R	1
Ni, L	2
Di, X	1
Ma, B	1
Niu, S	1
Rong, Z	1
Liu, C	1
Yang, GH	1
Li, YC	1
Wang, ZQ	1
Liu, B	1
Ye, W	1
Zeng, R	1
Miao, SY	1
Wang, LF	1
Liu, CW	1
Lapi, D	1
Vagnani, S	1
Cardaci, E	1
Paterni, M	1
Colantuoni, A	1

Clinical Trials (2)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Protective Effect of Melatonin on Smoke-induced Vascular Injury in Human[NCT02591238]			Phase 4	68 participants (Actual)	Interventional	2015-06-30	Completed
The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy[NCT03115034]			Phase 4	60 participants (Actual)	Interventional	2016-06-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of Fbg.

(NCT02591238)
Timeframe: Three months

Intervention	g/L (Mean)
IV Non-smoker + Placebo	2.76
III Non-smoker + Melatonin	2.38
II Smoker + Placebo	2.89
I Smoker + Melatonin	2.49

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of FFA.

(NCT02591238)
Timeframe: Three months.

Intervention	umol/L (Mean)
IV Non-smoker + Placebo	389
III Non-smoker + Melatonin	382
II Smoker + Placebo	499
I Smoker + Melatonin	425

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of Glu.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	4.4
III Non-smoker + Melatonin	4.24
II Smoker + Placebo	5.02
I Smoker + Melatonin	4.79

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of LDL-C.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	1.85
III Non-smoker + Melatonin	1.95
II Smoker + Placebo	2.2
I Smoker + Melatonin	2.19

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of TC.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	4.51
III Non-smoker + Melatonin	4.5
II Smoker + Placebo	4.74
I Smoker + Melatonin	4.45

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of TG.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	1.21
III Non-smoker + Melatonin	1.23
II Smoker + Placebo	1.42
I Smoker + Melatonin	1.41

Reviews

1 review available for melatonin and Carotid Stenosis

Article	Year
Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis. Molecules (Basel, Switzerland), 2021, Feb-04, Volume: 26, Issue:4 Topics: Animals; Carotid Artery Diseases; Carotid Stenosis; Humans; Melatonin	2021

Other Studies

2 other studies available for melatonin and Carotid Stenosis

Article	Year
Protective effect of melatonin on cigarette smoke-induced restenosis in rat carotid arteries after balloon injury. Journal of pineal research, 2014, Volume: 57, Issue:4 Topics: Angioplasty, Balloon; Animals; Anti-Inflammatory Agents; Blotting, Western; Carotid Arteries; Caroti	2014
Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion. Journal of pineal research, 2011, Volume: 51, Issue:1 Topics: Analysis of Variance; Animals; Capillary Permeability; Carotid Artery, Common; Carotid Stenosis; Cer	2011