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Page last updated: 2024-10-19

melatonin and Carotid Artery Narrowing

melatonin has been researched along with Carotid Artery Narrowing in 3 studies

Research Excerpts

Excerpt	Relevance	Reference
"Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, and neuroprotective properties."	2.72	Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis. ( Di, X; Liu, C; Ma, B; Ni, L; Niu, S; Rong, Z; Zhang, R, 2021)
" At the end of BCCAO, melatonin highest dosage caused order 2 arteriole diameter reduction by 4."	1.37	Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion. ( Cardaci, E; Colantuoni, A; Lapi, D; Paterni, M; Vagnani, S, 2011)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Zhang, R	1
Ni, L	2
Di, X	1
Ma, B	1
Niu, S	1
Rong, Z	1
Liu, C	1
Yang, GH	1
Li, YC	1
Wang, ZQ	1
Liu, B	1
Ye, W	1
Zeng, R	1
Miao, SY	1
Wang, LF	1
Liu, CW	1
Lapi, D	1
Vagnani, S	1
Cardaci, E	1
Paterni, M	1
Colantuoni, A	1

Clinical Trials (2)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Protective Effect of Melatonin on Smoke-induced Vascular Injury in Human[NCT02591238]			Phase 4	68 participants (Actual)	Interventional	2015-06-30	Completed
The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy[NCT03115034]			Phase 4	60 participants (Actual)	Interventional	2016-06-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of Fbg.

(NCT02591238)
Timeframe: Three months

Intervention	g/L (Mean)
IV Non-smoker + Placebo	2.76
III Non-smoker + Melatonin	2.38
II Smoker + Placebo	2.89
I Smoker + Melatonin	2.49

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of FFA.

(NCT02591238)
Timeframe: Three months.

Intervention	umol/L (Mean)
IV Non-smoker + Placebo	389
III Non-smoker + Melatonin	382
II Smoker + Placebo	499
I Smoker + Melatonin	425

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of Glu.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	4.4
III Non-smoker + Melatonin	4.24
II Smoker + Placebo	5.02
I Smoker + Melatonin	4.79

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of LDL-C.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	1.85
III Non-smoker + Melatonin	1.95
II Smoker + Placebo	2.2
I Smoker + Melatonin	2.19

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of TC.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	4.51
III Non-smoker + Melatonin	4.5
II Smoker + Placebo	4.74
I Smoker + Melatonin	4.45

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of TG.

(NCT02591238)
Timeframe: Three months.

Intervention	mmol/L (Mean)
IV Non-smoker + Placebo	1.21
III Non-smoker + Melatonin	1.23
II Smoker + Placebo	1.42
I Smoker + Melatonin	1.41

Reviews

1 review available for melatonin and Carotid Artery Narrowing

Article	Year
Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis. Molecules (Basel, Switzerland), 2021, Feb-04, Volume: 26, Issue:4 Topics: Animals; Carotid Artery Diseases; Carotid Stenosis; Humans; Melatonin	2021

Other Studies

2 other studies available for melatonin and Carotid Artery Narrowing

Article	Year
Protective effect of melatonin on cigarette smoke-induced restenosis in rat carotid arteries after balloon injury. Journal of pineal research, 2014, Volume: 57, Issue:4 Topics: Angioplasty, Balloon; Animals; Anti-Inflammatory Agents; Blotting, Western; Carotid Arteries; Caroti	2014
Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion. Journal of pineal research, 2011, Volume: 51, Issue:1 Topics: Analysis of Variance; Animals; Capillary Permeability; Carotid Artery, Common; Carotid Stenosis; Cer	2011