melatonin has been researched along with Cardiac Toxicity in 25 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of this systematic review indicated that co-administration of melatonin ameliorates the doxorubicin-induced cardiotoxicity." | 9.05 | The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review. ( Farhood, B; Haghi-Aminjan, H; Hooshangi Shayesteh, MR; Mortezaee, K; Najafi, M, 2020) |
| "Based on the promising effects of melatonin on mitochondria, melatonin may mitigate AlP-induced cardiotoxicity and might be potentially suggested as cardioprotective in AlP-intoxicated patients." | 8.95 | A review of the protective role of melatonin during phosphine-induced cardiotoxicity: focus on mitochondrial dysfunction, oxidative stress and apoptosis. ( Abdollahi, M; Asghari, MH; de Oliveira, MR; Nabavi, SM, 2017) |
| " Although several pharmacological interventions, including melatonin and metformin, have been reported to protect against various cardiovascular diseases, their potential roles in trastuzumab-induced cardiotoxicity remain elusive." | 8.31 | Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Kerdphoo, S; Khuanjing, T; Maneechote, C; Nawara, W; Prathumsap, N; Shinlapawittayatorn, K, 2023) |
| "This study aims to investigate the protective effects of thymoquinone and melatonin on the heart against doxorubicin-induced cardiotoxicity in rats." | 7.96 | The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats. ( Akyol, S; Durdagi, G; Oyar, EO; Ozbek, M; Pehlivan, DY, 2020) |
| "This study was conducted to investigate the protective effect of melatonin against aflatoxin B1 (AFB1) cardiotoxicity by evaluating NOD-like receptor family pyrin domain containing protein 3 (NLRP3) signalling." | 7.96 | Melatonin attenuates AFB1-induced cardiotoxicity via the NLRP3 signalling pathway. ( Gao, H; Ge, J; Hao, Y; Li, J; Pan, Y; Yan, H, 2020) |
| "The present study aimed to determine the protective effect of melatonin and agomelatine on DOX-induced cardiotoxicity in rats by electrocardiographic, scintigraphic and biochemical methods." | 7.91 | Cardioprotective effect of melatonin and agomelatine on doxorubicin-induced cardiotoxicity in a rat model: an electrocardiographic, scintigraphic and biochemical study. ( Aygun, H; Gul, SS, 2019) |
| " Melatonin treatment prevented all the parameters of adriamycin-induced cardiotoxicity in rats." | 7.80 | Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats. ( Aydın, D; Aygün, H; Bilginoğlu, A; Ozsoy, S, 2014) |
| "Melatonin has been shown to act as a protector against various conditions in which free radicals cause molecular and tissue injury." | 6.72 | Melatonin attenuates chemical-induced cardiotoxicity. ( Hayes, AW; Heydari, FS; Karimi, G; Reiter, RJ; Zare, S; Zirak, MR, 2021) |
| "Melatonin is a potent antioxidant, is nontoxic, and has been shown to influence mitochondrial homeostasis and function." | 6.50 | Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. ( Engelbrecht, AM; Govender, J; Loos, B; Marais, E, 2014) |
| "Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target organisms, which has raised the public's attention." | 5.62 | Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish. ( Chen, D; Feng, X; Feng, Z; Gao, Q; Liu, X; Tang, Y; Zhao, X, 2021) |
| " Unfortunately, cumulative and irreversible cardiotoxicity of Dox is the most prominent adverse effect which limits its use." | 5.62 | Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Kerdphoo, S; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N; Shinlapawittayatorn, K, 2021) |
| "The clinical application of doxorubicin, one of the most effective anticancer drugs, has been limited due to its adverse effects, including cardiotoxicity." | 5.56 | Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage. ( Choe, W; Ha, J; Hoang, DH; Kang, I; Kim, SS; Song, M; Tran, QH; Yang, G, 2020) |
| "Melatonin is a documented potent antioxidant, nontoxic and cardioprotective agent, and it is involved in maintaining mitochondrial homeostasis and function." | 5.48 | AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. ( Di, S; Liu, D; Ma, Z; Qiao, S; Reiter, RJ; Xu, L; Yang, J; Yang, Y; Yuan, J, 2018) |
| "Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart." | 5.46 | On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity. ( Abdollahi, M; Aminjan, HH; Asghari, MH; Baeeri, M; Baghaei, A; Hassani, S; Jafari, A; Moghadamnia, AA; Moloudizargari, M; Ostad, SN; Rahimifard, M; Solgi, R, 2017) |
| "The results of this systematic review indicated that co-administration of melatonin ameliorates the doxorubicin-induced cardiotoxicity." | 5.05 | The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review. ( Farhood, B; Haghi-Aminjan, H; Hooshangi Shayesteh, MR; Mortezaee, K; Najafi, M, 2020) |
| "Based on the promising effects of melatonin on mitochondria, melatonin may mitigate AlP-induced cardiotoxicity and might be potentially suggested as cardioprotective in AlP-intoxicated patients." | 4.95 | A review of the protective role of melatonin during phosphine-induced cardiotoxicity: focus on mitochondrial dysfunction, oxidative stress and apoptosis. ( Abdollahi, M; Asghari, MH; de Oliveira, MR; Nabavi, SM, 2017) |
| " Although several pharmacological interventions, including melatonin and metformin, have been reported to protect against various cardiovascular diseases, their potential roles in trastuzumab-induced cardiotoxicity remain elusive." | 4.31 | Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Kerdphoo, S; Khuanjing, T; Maneechote, C; Nawara, W; Prathumsap, N; Shinlapawittayatorn, K, 2023) |
| "This study aims to investigate the protective effects of thymoquinone and melatonin on the heart against doxorubicin-induced cardiotoxicity in rats." | 3.96 | The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats. ( Akyol, S; Durdagi, G; Oyar, EO; Ozbek, M; Pehlivan, DY, 2020) |
| "This study was conducted to investigate the protective effect of melatonin against aflatoxin B1 (AFB1) cardiotoxicity by evaluating NOD-like receptor family pyrin domain containing protein 3 (NLRP3) signalling." | 3.96 | Melatonin attenuates AFB1-induced cardiotoxicity via the NLRP3 signalling pathway. ( Gao, H; Ge, J; Hao, Y; Li, J; Pan, Y; Yan, H, 2020) |
| "The present study aimed to determine the protective effect of melatonin and agomelatine on DOX-induced cardiotoxicity in rats by electrocardiographic, scintigraphic and biochemical methods." | 3.91 | Cardioprotective effect of melatonin and agomelatine on doxorubicin-induced cardiotoxicity in a rat model: an electrocardiographic, scintigraphic and biochemical study. ( Aygun, H; Gul, SS, 2019) |
| " Melatonin treatment prevented all the parameters of adriamycin-induced cardiotoxicity in rats." | 3.80 | Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats. ( Aydın, D; Aygün, H; Bilginoğlu, A; Ozsoy, S, 2014) |
| "Melatonin has been shown to act as a protector against various conditions in which free radicals cause molecular and tissue injury." | 2.72 | Melatonin attenuates chemical-induced cardiotoxicity. ( Hayes, AW; Heydari, FS; Karimi, G; Reiter, RJ; Zare, S; Zirak, MR, 2021) |
| "Melatonin is a potent antioxidant, is nontoxic, and has been shown to influence mitochondrial homeostasis and function." | 2.50 | Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. ( Engelbrecht, AM; Govender, J; Loos, B; Marais, E, 2014) |
| "Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target organisms, which has raised the public's attention." | 1.62 | Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish. ( Chen, D; Feng, X; Feng, Z; Gao, Q; Liu, X; Tang, Y; Zhao, X, 2021) |
| " MEL weakened the toxic effects of DOX on the cardiac tissue and it is shown histologically." | 1.62 | Effects of Melatonin and Adrenomedullin in Reducing the Cardiotoxic Effects of Doxorubicin in Rats. ( Bahceci, SA; Durdagi, G; Oyar, EO; Ozbek, M; Pehlivan, DY, 2021) |
| " Unfortunately, cumulative and irreversible cardiotoxicity of Dox is the most prominent adverse effect which limits its use." | 1.62 | Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Kerdphoo, S; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N; Shinlapawittayatorn, K, 2021) |
| "The clinical application of doxorubicin, one of the most effective anticancer drugs, has been limited due to its adverse effects, including cardiotoxicity." | 1.56 | Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage. ( Choe, W; Ha, J; Hoang, DH; Kang, I; Kim, SS; Song, M; Tran, QH; Yang, G, 2020) |
| "Melatonin is a documented potent antioxidant, nontoxic and cardioprotective agent, and it is involved in maintaining mitochondrial homeostasis and function." | 1.48 | AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. ( Di, S; Liu, D; Ma, Z; Qiao, S; Reiter, RJ; Xu, L; Yang, J; Yang, Y; Yuan, J, 2018) |
| "Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart." | 1.46 | On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity. ( Abdollahi, M; Aminjan, HH; Asghari, MH; Baeeri, M; Baghaei, A; Hassani, S; Jafari, A; Moghadamnia, AA; Moloudizargari, M; Ostad, SN; Rahimifard, M; Solgi, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (52.00) | 24.3611 |
| 2020's | 12 (48.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arinno, A | 3 |
| Maneechote, C | 3 |
| Khuanjing, T | 3 |
| Prathumsap, N | 3 |
| Chunchai, T | 3 |
| Arunsak, B | 3 |
| Nawara, W | 2 |
| Kerdphoo, S | 3 |
| Shinlapawittayatorn, K | 3 |
| Chattipakorn, SC | 3 |
| Chattipakorn, N | 3 |
| Zhang, W | 1 |
| Wang, X | 1 |
| Tang, Y | 2 |
| Huang, C | 1 |
| Najafi, M | 1 |
| Hooshangi Shayesteh, MR | 1 |
| Mortezaee, K | 1 |
| Farhood, B | 1 |
| Haghi-Aminjan, H | 1 |
| Li, HR | 1 |
| Wang, C | 1 |
| Sun, P | 1 |
| Liu, DD | 1 |
| Du, GQ | 1 |
| Tian, JW | 1 |
| Liu, X | 1 |
| Gao, Q | 1 |
| Feng, Z | 1 |
| Zhao, X | 1 |
| Chen, D | 1 |
| Feng, X | 1 |
| Jiang, J | 1 |
| Liang, S | 1 |
| Zhang, J | 1 |
| Du, Z | 1 |
| Xu, Q | 1 |
| Duan, J | 1 |
| Sun, Z | 1 |
| Zare, S | 1 |
| Heydari, FS | 1 |
| Hayes, AW | 1 |
| Reiter, RJ | 2 |
| Zirak, MR | 1 |
| Karimi, G | 1 |
| Pehlivan, DY | 2 |
| Durdagi, G | 2 |
| Oyar, EO | 2 |
| Akyol, S | 1 |
| Ozbek, M | 2 |
| Yan, H | 1 |
| Ge, J | 1 |
| Gao, H | 1 |
| Pan, Y | 1 |
| Hao, Y | 1 |
| Li, J | 1 |
| Yang, G | 1 |
| Song, M | 1 |
| Hoang, DH | 1 |
| Tran, QH | 1 |
| Choe, W | 1 |
| Kang, I | 1 |
| Kim, SS | 1 |
| Ha, J | 1 |
| Bahceci, SA | 1 |
| Ongnok, B | 1 |
| Asghari, MH | 4 |
| Moloudizargari, M | 3 |
| Baeeri, M | 1 |
| Baghaei, A | 1 |
| Rahimifard, M | 1 |
| Solgi, R | 1 |
| Jafari, A | 1 |
| Aminjan, HH | 1 |
| Hassani, S | 1 |
| Moghadamnia, AA | 1 |
| Ostad, SN | 1 |
| Abdollahi, M | 4 |
| Shetab-Boushehri, SV | 1 |
| Zamani, N | 1 |
| Hassanian-Moghaddam, H | 1 |
| Liu, D | 1 |
| Ma, Z | 1 |
| Di, S | 1 |
| Yang, Y | 1 |
| Yang, J | 1 |
| Xu, L | 1 |
| Qiao, S | 1 |
| Yuan, J | 1 |
| Aygun, H | 2 |
| Gul, SS | 1 |
| Savran, M | 1 |
| Asci, H | 1 |
| Ozmen, O | 1 |
| Erzurumlu, Y | 1 |
| Savas, HB | 1 |
| Sonmez, Y | 1 |
| Sahin, Y | 1 |
| Bilginoğlu, A | 1 |
| Aydın, D | 1 |
| Ozsoy, S | 1 |
| Özdoğru, İ | 1 |
| Govender, J | 2 |
| Loos, B | 2 |
| Marais, E | 1 |
| Engelbrecht, AM | 2 |
| de Oliveira, MR | 1 |
| Nabavi, SM | 1 |
4 reviews available for melatonin and Cardiac Toxicity
| Article | Year |
|---|---|
The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review.
Topics: Antibiotics, Antineoplastic; Antioxidants; Cardiotoxicity; Doxorubicin; Humans; Melatonin; Neoplasms | 2020 |
Melatonin attenuates chemical-induced cardiotoxicity.
Topics: Animals; Cardiotoxicity; Humans; Melatonin | 2021 |
Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Cardiotoxicity; Doxorubicin; Heart; Humans; Mela | 2014 |
A review of the protective role of melatonin during phosphine-induced cardiotoxicity: focus on mitochondrial dysfunction, oxidative stress and apoptosis.
Topics: Animals; Apoptosis; Cardiotoxicity; Humans; Melatonin; Mitochondria; Oxidative Stress; Phosphines; P | 2017 |
21 other studies available for melatonin and Cardiac Toxicity
| Article | Year |
|---|---|
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy.
Topics: Animals; Cardiotoxicity; Inflammation; Male; Melatonin; Metformin; Mitochondria; Rats; Rats, Wistar; | 2023 |
Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway.
Topics: Animals; Apoptosis; Cardiomyopathies; Cardiotoxicity; Doxorubicin; Heart Injuries; Melatonin; Mice; | 2023 |
Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cardiotoxicity; Cell Death; Cell Line; Down-Regulation; Doxo | 2020 |
Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Cardiotoxicity; Disease Models, Animal; GA | 2021 |
Melatonin ameliorates PM
Topics: Acetylation; Animals; Antioxidants; Cardiomyopathies; Cardiotoxicity; Cell Line; Disease Models, Ani | 2021 |
The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats.
Topics: Animals; Antibiotics, Antineoplastic; Benzoquinones; Cardiotoxicity; Doxorubicin; Heart; Melatonin; | 2020 |
Melatonin attenuates AFB1-induced cardiotoxicity via the NLRP3 signalling pathway.
Topics: Aflatoxin B1; Animals; Cardiotoxicity; Inflammasomes; Melatonin; NLR Family, Pyrin Domain-Containing | 2020 |
Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotoxicity; Cell Line | 2020 |
Effects of Melatonin and Adrenomedullin in Reducing the Cardiotoxic Effects of Doxorubicin in Rats.
Topics: Action Potentials; Adrenomedullin; Animals; Anti-Inflammatory Agents; Antioxidants; Cardiotoxicity; | 2021 |
Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics.
Topics: Animals; Antibiotics, Antineoplastic; Cardiotonic Agents; Cardiotoxicity; Cell Line; Dose-Response R | 2021 |
On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aluminum Compounds; Animals; Blood Pressure; Cardioto | 2017 |
In response to the comments on our recently published paper entitled "on the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity".
Topics: Aluminum Compounds; Cardiotoxicity; Humans; Melatonin; Phosphines | 2017 |
Comment on Asghari et al. 2017: On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity. Arch Toxicol [Epub ahead of print]. doi:10.1007/s00204-017-1998-6.
Topics: Aluminum Compounds; Cardiotoxicity; Humans; Melatonin; Phosphines | 2017 |
RE: Comment on Asghari et al. 2017: On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity.
Topics: Aluminum Compounds; Cardiotoxicity; Humans; Melatonin; Phosphines | 2018 |
Reply to Zamani and Hassanian-Moghaddam, 2017: being specific and targeting disease-causing pathology matter in therapeutics.
Topics: Aluminum Compounds; Cardiotoxicity; Humans; Melatonin; Phosphines | 2018 |
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis.
Topics: AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Apoptosis; Cardiomyopathies; Ca | 2018 |
Cardioprotective effect of melatonin and agomelatine on doxorubicin-induced cardiotoxicity in a rat model: an electrocardiographic, scintigraphic and biochemical study.
Topics: Acetamides; Animals; Antibiotics, Antineoplastic; Antioxidants; Cardiotoxicity; Doxorubicin; Electro | 2019 |
Melatonin protects the heart and endothelium against high fructose corn syrup consumption-induced cardiovascular toxicity via SIRT-1 signaling.
Topics: Animals; Aorta; Biomarkers; Cardiotoxicity; Cardiovascular Diseases; Endothelium, Vascular; Heart; H | 2019 |
Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats.
Topics: Animals; Antioxidants; Cardiotoxicity; Doxorubicin; Electrocardiography; Heart; Lipid Peroxidation; | 2014 |
Anthracycline-induced cardiotoxicity.
Topics: Animals; Antioxidants; Cardiotoxicity; Doxorubicin; Heart; Lipid Peroxidation; Male; Melatonin | 2014 |
Melatonin: a protective role against doxorubicin-induced cardiotoxicity.
Topics: Antibiotics, Antineoplastic; Cardiotoxicity; Doxorubicin; Humans; Melatonin; Mitochondria | 2015 |