Page last updated: 2024-10-19

melatonin and Carcinoma, Squamous Cell

melatonin has been researched along with Carcinoma, Squamous Cell in 27 studies

Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"Oesophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-associated death in the world and novel therapeutic alternatives are urgently warranted."5.43Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway. ( Bai, L; Chen, DL; Chen, LZ; Ju, HQ; Lu, YX; Mo, HY; Sheng, H; Wang, DS; Wang, F; Wu, QN; Xie, D; Xu, RH; Yu, HE; Yun, JP; Zeng, ZL, 2016)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Oral squamous cell carcinomas are one of the most common cancers worldwide with aggressive behavior and poor prognosis."1.91Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS. ( Choi, WS; Li, X; Su, Y; Tao, Z; Wang, C; Wang, L; Zhu, W, 2023)
"Melatonin has been shown to have oncostatic effects in different types of cancers."1.91Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress. ( Acuña-Castroviejo, D; Carriel, V; Escames, G; Fernández-Gil, BI; Fernández-Martínez, J; Florido, J; García-Tárraga, P; Garcia-Verdugo, JM; González-García, P; Guerra-Librero, A; López-Rodríguez, A; Martinez-Ruiz, L; Oppel, F; Rodriguez-Santana, C; Rusanova, I; Sánchez-Porras, D; Sudhoff, H; Ten-Steve, A, 2023)
"Melatonin receptors can inhibit breast and prostate cancers; however, little is known regarding their effects on oral squamous cell carcinoma."1.72Effects of melatonin receptor expression on prognosis and survival in oral squamous cell carcinoma patients. ( Hwang, DS; Jang, MA; Kim, GC; Kim, UK; Park, HK; Ryu, MH, 2022)
"Melatonin has been demonstrated to exhibit oncostatic effects."1.62Melatonin Suppresses Oral Squamous Cell Carcinomas Migration and Invasion through Blocking FGF19/FGFR 4 Signaling Pathway. ( Choi, WS; Su, Y; Wang, L, 2021)
"Melatonin treatment enhanced arecoline-induced ROS production, cytotoxicity, G2/M phase arrest, and cell apoptosis in OSCC cells."1.62Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma. ( Chiu, KC; Hsia, SM; Lan, WC; Shieh, TM; Shih, YH; Tsai, BH; Wang, TH; Wu, LJ, 2021)
"The global prevalence of head and neck squamous cell carcinoma (HNSCC) remains high, and its prognosis poor."1.56Melatonin Exerts Anticancer Effects in Human Tongue Squamous Cell Carcinoma Cells by Promoting Autophagy. ( Ahn, YT; An, WG; Choi, SW; Jang, HB; Kim, JY; Lee, IW; Lee, JC; Sung, ES, 2020)
"Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway."1.48Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. ( Acuña-Castroviejo, D; Carriel, V; Diaz-Casado, ME; Escames, G; Fernandez-Gil, BI; Florido, J; García-López, S; Guerra-Librero, A; López, LC; Martinez-Ruiz, L; Mendivil-Perez, M; Nieto, A; Ortega-Arellano, H; Reiter, RJ; Rusanova, I; Shen, YQ; Soto-Mercado, V, 2018)
"By assessing oral squamous cell carcinoma (OSCC) tissue arrays through immunohistochemistry, we examined whether aberrant LSD1 overexpression in OSCC is associated with poor prognosis."1.46Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. ( Chen, YW; Hsieh, CC; Lin, CK; Lin, GJ; Ma, KH; Shieh, YS; Sytwu, HK; Tsao, CH; Yang, CY, 2017)
"Oesophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-associated death in the world and novel therapeutic alternatives are urgently warranted."1.43Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway. ( Bai, L; Chen, DL; Chen, LZ; Ju, HQ; Lu, YX; Mo, HY; Sheng, H; Wang, DS; Wang, F; Wu, QN; Xie, D; Xu, RH; Yu, HE; Yun, JP; Zeng, ZL, 2016)
"Treatment with melatonin prior to irradiation did not produce any significant change in apoptosis."1.40CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells. ( Jeong, JW; Kim, JE; Kim, W, 2014)
"We documented 10,799 incident skin cancers in 68,336 women in the Nurses' Health Study from June 1988 to June 2006 and examined the relationship between rotating night shifts and skin cancer."1.37Rotating night shifts and risk of skin cancer in the nurses' health study. ( Han, J; Li, TY; Qureshi, AA; Razavi, P; Schernhammer, ES, 2011)
"Treatment with melatonin and metformin and their combinations was followed by significantly lower tumor multiplicity and smaller size, longer latency period and survival of tumor-bearers."1.36[Melatonin and metformin inhibit skin carcinogenesis induced by benz(a)pyrene in mice]. ( Anisimov, VN; Deriabina, ON; Plotnikova, NA, 2010)
" EMF near fields exposure conditions were as follows: skin local peak specific absorption rate (SAR) 2."1.31Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields. ( Fujiwara, O; Imaida, K; Kato, K; Kuzutani, K; Ogiso, T; Shirai, T; Wang, J, 2001)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.41)18.7374
1990's1 (3.70)18.2507
2000's3 (11.11)29.6817
2010's10 (37.04)24.3611
2020's11 (40.74)2.80

Authors

AuthorsStudies
Park, HK1
Ryu, MH1
Hwang, DS1
Kim, GC1
Jang, MA1
Kim, UK1
Shigeishi, H1
Yokoyama, S1
Murodumi, H1
Sakuma, M1
Fukada, S1
Okuda, S1
Yamakado, N1
Ono, S1
Takechi, M1
Ohta, K1
Wang, L3
Su, Y3
Choi, WS3
Wang, C2
Tao, Z2
Zhu, W2
Li, X1
Martinez-Ruiz, L2
Florido, J2
Rodriguez-Santana, C1
López-Rodríguez, A1
Guerra-Librero, A2
Fernández-Gil, BI2
García-Tárraga, P1
Garcia-Verdugo, JM1
Oppel, F1
Sudhoff, H1
Sánchez-Porras, D1
Ten-Steve, A1
Fernández-Martínez, J1
González-García, P1
Rusanova, I2
Acuña-Castroviejo, D2
Carriel, V2
Escames, G2
Shih, YH1
Chiu, KC1
Wang, TH1
Lan, WC1
Tsai, BH1
Wu, LJ1
Hsia, SM1
Shieh, TM1
Madapusi Balaji, T1
Varadarajan, S1
Jagannathan, R1
Raj, AT1
Sridhar, LP1
Patil, S1
Sung, ES1
Kim, JY1
Ahn, YT1
Lee, IW1
Choi, SW1
Jang, HB1
Lee, JC1
An, WG1
Salarić, I1
Karmelić, I1
Lovrić, J1
Baždarić, K1
Rožman, M1
Čvrljević, I1
Zajc, I1
Brajdić, D1
Macan, D1
Yang, CY1
Lin, CK1
Tsao, CH1
Hsieh, CC1
Lin, GJ1
Ma, KH1
Shieh, YS1
Sytwu, HK1
Chen, YW1
Fan, T1
Pi, H1
Li, M1
Ren, Z1
He, Z1
Zhu, F1
Tian, L1
Tu, M1
Xie, J1
Liu, M1
Li, Y1
Tan, M1
Li, G1
Qing, W1
Reiter, RJ2
Yu, Z1
Wu, H1
Zhou, Z1
Shen, YQ1
García-López, S1
Mendivil-Perez, M1
Soto-Mercado, V1
Ortega-Arellano, H1
Diaz-Casado, ME1
Nieto, A1
López, LC1
Kim, W1
Jeong, JW1
Kim, JE1
Lu, YX1
Chen, DL1
Wang, DS1
Chen, LZ1
Mo, HY1
Sheng, H1
Bai, L1
Wu, QN1
Yu, HE1
Xie, D1
Yun, JP1
Zeng, ZL1
Wang, F1
Ju, HQ1
Xu, RH1
Deriabina, ON1
Plotnikova, NA1
Anisimov, VN1
Schernhammer, ES1
Razavi, P1
Li, TY1
Qureshi, AA1
Han, J1
Mazzoccoli, G2
Sothern, RB1
Pazienza, V1
Piepoli, A1
Muscarella, LA1
Giuliani, F1
Tarquini, R2
Durfort, T1
Francois, JC1
Di Bella, G1
Colori, B1
Zwirska-Korczala, K1
Adamczyk-Sowa, M1
Polaniak, R1
Sowa, P1
Birkner, E1
Drzazga, Z1
Brzozowski, T1
Konturek, SJ1
Dauchy, RT1
Dauchy, EM1
Davidson, LK1
Krause, JA1
Lynch, DT1
Tirrell, PC1
Tirrell, RP1
Sauer, LA1
Van der Riet, P1
Blask, DE1
Deĭneko, GM1
Kvetnoĭ, IM1
Bartsch, C1
Kvetnoy, I1
Kvetnaia, T1
Bartsch, H1
Molotkov, A1
Franz, H1
Raikhlin, N1
Mecke, D1
Imaida, K1
Kuzutani, K1
Wang, J1
Fujiwara, O1
Ogiso, T1
Kato, K1
Shirai, T1
Wurtman, RJ1

Reviews

2 reviews available for melatonin and Carcinoma, Squamous Cell

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
The effects of light on man and other mammals.
    Annual review of physiology, 1975, Volume: 37

    Topics: Animals; Bilirubin; Biological Clocks; Birds; Calcium; Carcinoma, Squamous Cell; Environment; Female

1975

Trials

1 trial available for melatonin and Carcinoma, Squamous Cell

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023

Other Studies

25 other studies available for melatonin and Carcinoma, Squamous Cell

ArticleYear
Effects of melatonin receptor expression on prognosis and survival in oral squamous cell carcinoma patients.
    International journal of oral and maxillofacial surgery, 2022, Volume: 51, Issue:6

    Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Lymphatic Metastas

2022
Melatonin enhances cisplatin-induced cell death through inhibition of DERL1 in mesenchymal-like CD44
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2022, Volume: 51, Issue:3

    Topics: Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Gene Expressi

2022
Melatonin Suppresses Oral Squamous Cell Carcinomas Migration and Invasion through Blocking FGF19/FGFR 4 Signaling Pathway.
    International journal of molecular sciences, 2021, Sep-14, Volume: 22, Issue:18

    Topics: Carcinoma, Squamous Cell; Cell Movement; Cell Survival; Fibroblast Growth Factors; Gene Expression R

2021
Tumor-associated macrophages facilitate oral squamous cell carcinomas migration and invasion by MIF/NLRP3/IL-1β circuit: A crosstalk interrupted by melatonin.
    Biochimica et biophysica acta. Molecular basis of disease, 2023, Volume: 1869, Issue:5

    Topics: Animals; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Intramolecular Oxidoreductases;

2023
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS.
    Cellular & molecular biology letters, 2023, May-02, Volume: 28, Issue:1

    Topics: Animals; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Disease Models, Animal; Ferroptosis; Head a

2023
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 167

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Head and Neck Neoplasms; Heterografts; Humans

2023
Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2021, Volume: 120, Issue:1 Pt 3

    Topics: Areca; Arecoline; Carcinoma, Squamous Cell; DNA Damage; Humans; Melatonin; Mouth Neoplasms; Reactive

2021
Hypothesizing the potential role of melatonin in inhibiting epithelial to mesenchymal transition in oral squamous cell carcinoma.
    Medical hypotheses, 2020, Volume: 145

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Humans; Melatonin; Mo

2020
Melatonin Exerts Anticancer Effects in Human Tongue Squamous Cell Carcinoma Cells by Promoting Autophagy.
    Anticancer research, 2020, Volume: 40, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Extracts; Cell Line, Tum

2020
Salivary melatonin in oral squamous cell carcinoma patients.
    Scientific reports, 2021, 06-24, Volume: 11, Issue:1

    Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Female; Humans; Male; Melatonin;

2021
Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.
    Oncotarget, 2017, May-16, Volume: 8, Issue:20

    Topics: Acetylation; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle

2017
Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma.
    Journal of pineal research, 2018, Volume: 64, Issue:2

    Topics: Adult; Aged; Animals; Antioxidants; Apoptosis; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Tran

2018
Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.
    Journal of pineal research, 2018, Volume: 64, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell L

2018
CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Antioxidants; Apoptosis; Blotting, Western; Ca

2014
Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway.
    Cell death & disease, 2016, 10-27, Volume: 7, Issue:10

    Topics: Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Syne

2016
[Melatonin and metformin inhibit skin carcinogenesis induced by benz(a)pyrene in mice].
    Voprosy onkologii, 2010, Volume: 56, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Squamous Cell; Catalase; Central Nervous

2010
Rotating night shifts and risk of skin cancer in the nurses' health study.
    Journal of the National Cancer Institute, 2011, Apr-06, Volume: 103, Issue:7

    Topics: Adult; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Confounding Factors, Epidemiologic; Female;

2011
Circadian aspects of growth hormone-insulin-like growth factor axis function in patients with lung cancer.
    Clinical lung cancer, 2012, Volume: 13, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous

2012
Chronodisruption in lung cancer and possible therapeutic approaches.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2011, Volume: 65, Issue:7

    Topics: Adenocarcinoma; Adult; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chronobiology Disor

2011
The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck.
    Neuro endocrinology letters, 2012, Volume: 33, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antioxidants; Calcium; Carcinoma

2012
Influence of extremely-low-frequency magnetic field on antioxidative melatonin properties in AT478 murine squamous cell carcinoma culture.
    Biological trace element research, 2004,Winter, Volume: 102, Issue:1-3

    Topics: Animals; Antioxidants; Carcinoma, Squamous Cell; Cell Line, Tumor; Electromagnetic Fields; Female; G

2004
Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids.
    Comparative medicine, 2007, Volume: 57, Issue:4

    Topics: Animals; Antineoplastic Agents; Biological Transport; Carcinoma, Squamous Cell; Cell Proliferation;

2007
[Endocrine cells in human laryngeal tumors (ectopic hormone secretion)].
    Arkhiv patologii, 1983, Volume: 45, Issue:2

    Topics: Carcinoma, Squamous Cell; Cell Differentiation; Follicle Stimulating Hormone; Growth Hormone; Hormon

1983
Nocturnal urinary 6-sulfatoxymelatonin and proliferating cell nuclear antigen-immunopositive tumor cells show strong positive correlations in patients with gastrointestinal and lung cancer.
    Journal of pineal research, 1997, Volume: 23, Issue:2

    Topics: Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Gastrointestinal Neoplasms; Humans; Immunoenzyme Tec

1997
Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields.
    Carcinogenesis, 2001, Volume: 22, Issue:11

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenocorticotropic Hormone; Animals; Carcinogens; Carcinoma, Squa

2001