melatonin has been researched along with Carcinoma, Hepatocellular in 48 studies
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the clinical efficacy of transcatheter arterial chemoembolization (TACE) and TACE+MLT (melatonin) on inoperable advanced primary hepatocellular carcinoma." | 9.10 | Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. ( Shen, F; Wang, K; Wu, MC; Yan, JJ, 2002) |
| "The mechanisms of resistance to the targeted drug sorafenib in the treatment of hepatocellular carcinoma (HCC) are poorly understood." | 7.91 | Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. ( Fan, L; Liu, J; Lu, Q; Sun, G; Wang, H; Wang, Y; Wei, W; Zhou, B, 2019) |
| "Melatonin has been shown to exert anticancer activity on hepatocellular carcinoma (HCC) through its antiproliferative and pro-apoptotic effect in both experimental and clinical studies, and sorafenib is the only approved drug for the systemic treatment of HCC." | 7.85 | Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. ( Gao, C; Herr, I; Hoffmann, K; Lin, S; Petrulionis, M; Schemmer, P, 2017) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 7.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| "Effects of sorafenib in hepatocellular carcinoma (HCC) are frequently transient due to tumor-acquired resistance, a phenotype that could be targeted by other molecules to reduce this adaptive response." | 7.83 | Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. ( Baulies, A; Fernández, A; Fernández-Checa, JC; Garcia-Ruiz, C; González-Gallego, J; Mauriz, JL; Méndez-Blanco, C; Ordóñez, R; Prieto-Domínguez, N, 2016) |
| "This study was to investigate whether melatonin (MLT) at pharmacologic concentrations (1 and 100 μM) had potential to influence the expressions of angiogenic (CCL2, CXCL6, IL8) and angiostatic (CXCL10) chemokine genes in two hepatocellular carcinoma (HCC) cell lines with different characteristics (cell line A, HCC24/KMUH, without susceptible to amphotericin B (AmB)-induced oxidative stress; cell line B, HCC38/KMUH, susceptible to AmB-induced oxidative stress)." | 7.76 | Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. ( Chuang, WL; Lin, ZY, 2010) |
| "Melatonin was recently reported to exert intrinsic antitumor activity in different cancers." | 5.91 | Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. ( Hamed, AR; Nabih, HK; Yahya, SMM, 2023) |
| "Melatonin is an alternative agent that may be helpful in treating HCC." | 5.91 | Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential. ( Bidóia, DL; Concato, VM; Cruz, EMS; de Almeida Chuffa, LG; de Morais, JMB; de Souza Cremer, M; Inoue, FSR; Machado, RRB; Mantovani, MS; Panis, C; Pavanelli, WR; Seiva, FRF; Silva, TF, 2023) |
| "Melatonin treatment at both doses strongly inhibited the proliferation, migration and invasion capacities of Huh7 and HepG2 cell lines, and melatonin treatment markedly induced the expression of the miRNA let7i-3p in cells." | 5.48 | Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction. ( Chang, JL; Chen, CC; Chen, CY; Hsueh, C; Li, WS; Lian, JH; Wang, TH; Yeh, CT, 2018) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 5.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| "Apoptosis resistance in hepatocellular carcinoma (HCC) is one of the most significant factors for hepatocarcinogenesis and tumor progression, and leads to resistance to conventional chemotherapy." | 5.39 | Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. ( Fan, L; Ma, T; Sun, G; Wei, W; Zhong, F, 2013) |
| "Six years after the diagnosis of untreatable hepatocellular carcinoma, the patient remains in a good condition." | 5.39 | Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin. ( Den Otter, W; Krastev, Z; Popov, D; Tomov, B; Tomova, R; Vladov, N, 2013) |
| "Chemoresistance in hepatocellular carcinoma (HCC) is associated with multiple cellular responses to environmental stresses, such as nutrient deprivation and hypoxia." | 5.39 | Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. ( Fan, L; Lei, Y; Li, X; Ma, T; Sun, G; Wei, W; Zhong, F, 2013) |
| "Experimental studies have showed that hepatocellular carcinoma (HCC) cells are susceptible to cytolysis of interleukin (IL)-2-activated lymphocytes." | 5.29 | Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Conti, A; Lissoni, P; Maestroni, GJ; Piperno, A; Pozzi, M; Ricci, G; Tancini, G, 1994) |
| "To observe the clinical efficacy of transcatheter arterial chemoembolization (TACE) and TACE+MLT (melatonin) on inoperable advanced primary hepatocellular carcinoma." | 5.10 | Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. ( Shen, F; Wang, K; Wu, MC; Yan, JJ, 2002) |
| "Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " The purpose of the current study was to reveal the possible protective effects of melatonin against AA-induced hepatic oxidative stress, hepatic inflammation, and hepatocellular proliferation in pinealectomized rats." | 4.31 | Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation. ( Altinoz, E; Bicer, Y; Elbe, H; Karayakali, M; Onal, MO; Ozturk, I, 2023) |
| "Using the gene expression profiles of four cancer cell lines from three types of gastrointestinal carcinomas before and after melatonin treatment, including gastric carcinoma (GC), colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC), differentially expressed genes (DEGs) and biological pathways influenced by melatonin were identified." | 3.96 | Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas. ( Ao, L; Chen, H; Guo, Z; Huang, H; Li, L; Li, Y; Sun, H; Wang, X; Zhou, R, 2020) |
| "The mechanisms of resistance to the targeted drug sorafenib in the treatment of hepatocellular carcinoma (HCC) are poorly understood." | 3.91 | Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. ( Fan, L; Liu, J; Lu, Q; Sun, G; Wang, H; Wang, Y; Wei, W; Zhou, B, 2019) |
| " Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer." | 3.85 | Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017) |
| "Melatonin has been shown to exert anticancer activity on hepatocellular carcinoma (HCC) through its antiproliferative and pro-apoptotic effect in both experimental and clinical studies, and sorafenib is the only approved drug for the systemic treatment of HCC." | 3.85 | Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. ( Gao, C; Herr, I; Hoffmann, K; Lin, S; Petrulionis, M; Schemmer, P, 2017) |
| "Effects of sorafenib in hepatocellular carcinoma (HCC) are frequently transient due to tumor-acquired resistance, a phenotype that could be targeted by other molecules to reduce this adaptive response." | 3.83 | Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. ( Baulies, A; Fernández, A; Fernández-Checa, JC; Garcia-Ruiz, C; González-Gallego, J; Mauriz, JL; Méndez-Blanco, C; Ordóñez, R; Prieto-Domínguez, N, 2016) |
| "Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells." | 3.79 | Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells. ( Carbajo-Pescador, S; Galle, PR; González-Gallego, J; Heise, M; Kashyap, A; Lorenz, S; Mauriz, JL; Steinmetz, C; Strand, S, 2013) |
| " Melatonin induces apoptosis in hepatocellular carcinoma (HCC) in experimental studies, but the effects of melatonin on endoplasmic reticulum (ER) stress-induced apoptosis in HCC have not been tested." | 3.78 | Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis. ( Fan, L; Ma, T; Sun, G; Wang, H; Wei, W; Zha, L; Zhong, F, 2012) |
| "This study was to investigate whether melatonin (MLT) at pharmacologic concentrations (1 and 100 μM) had potential to influence the expressions of angiogenic (CCL2, CXCL6, IL8) and angiostatic (CXCL10) chemokine genes in two hepatocellular carcinoma (HCC) cell lines with different characteristics (cell line A, HCC24/KMUH, without susceptible to amphotericin B (AmB)-induced oxidative stress; cell line B, HCC38/KMUH, susceptible to AmB-induced oxidative stress)." | 3.76 | Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. ( Chuang, WL; Lin, ZY, 2010) |
| "In this study, different doses (5 x 10(-5) M, 5 x 10(-4) M, 10(-3) M) of melatonin were administered into hepatocellular carcinoma cell line in vitro." | 3.75 | The effects of melatonin on human hepatoma (Hep G2) cell line. ( Arslan, M; Aydin, F; Deniz, O; Kavgaci, H; Kaynar, K; Ozdemir, F; Yildiz, B, 2009) |
| "Melatonin was given orally at 20 mg/day in the evening for at least 2 months." | 2.70 | Anti-angiogenic activity of melatonin in advanced cancer patients. ( Bucovec, R; Conti, A; Lissoni, P; Maestroni, GJ; Malugani, F; Rovelli, F, 2001) |
| "Melatonin was recently reported to exert intrinsic antitumor activity in different cancers." | 1.91 | Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. ( Hamed, AR; Nabih, HK; Yahya, SMM, 2023) |
| "Melatonin is an alternative agent that may be helpful in treating HCC." | 1.91 | Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential. ( Bidóia, DL; Concato, VM; Cruz, EMS; de Almeida Chuffa, LG; de Morais, JMB; de Souza Cremer, M; Inoue, FSR; Machado, RRB; Mantovani, MS; Panis, C; Pavanelli, WR; Seiva, FRF; Silva, TF, 2023) |
| "Two types of human hepatoma cell lines were used to explore the mechanism by which melatonin prevents the growth and metastasis of cancer cells in vitro." | 1.91 | Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design. ( Chen, L; Guo, X; Huang, J; Li, X; Liang, B; Liu, Y; Lu, X; Lv, Y; Qian, K; Sun, B; Sun, T; Zhang, H; Zhang, W; Zhao, H; Zhao, Y; Zheng, C; Zhu, L, 2023) |
| "After implantation of tissue-isolated hepatoma 7288CTC xenografts, tumor growth rates were markedly delayed, and tumor cAMP levels, LA metabolism, the Warburg effect, and growth signaling activities were decreased in rats in bLAD compared with CWF daytime lighting." | 1.48 | Effect of Daytime Blue-enriched LED Light on the Nighttime Circadian Melatonin Inhibition of Hepatoma 7288CTC Warburg Effect and Progression. ( Anbalagan, M; Belancio, VP; Blask, DE; Dauchy, EM; Dauchy, RT; Dupepe, LM; Hill, SM; Wren-Dail, MA; Xiang, S, 2018) |
| "Melatonin treatment at both doses strongly inhibited the proliferation, migration and invasion capacities of Huh7 and HepG2 cell lines, and melatonin treatment markedly induced the expression of the miRNA let7i-3p in cells." | 1.48 | Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction. ( Chang, JL; Chen, CC; Chen, CY; Hsueh, C; Li, WS; Lian, JH; Wang, TH; Yeh, CT, 2018) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 1.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| "Apoptosis resistance in hepatocellular carcinoma (HCC) is one of the most significant factors for hepatocarcinogenesis and tumor progression, and leads to resistance to conventional chemotherapy." | 1.39 | Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. ( Fan, L; Ma, T; Sun, G; Wei, W; Zhong, F, 2013) |
| "Six years after the diagnosis of untreatable hepatocellular carcinoma, the patient remains in a good condition." | 1.39 | Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin. ( Den Otter, W; Krastev, Z; Popov, D; Tomov, B; Tomova, R; Vladov, N, 2013) |
| "In this study, we used human HepG2 liver cancer cells as an in vitro model to investigate the anti-angiogenic effects of melatonin." | 1.39 | Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. ( Benet, M; Carbajo-Pescador, S; García-Palomo, A; González-Gallego, J; Jover, R; Mauriz, JL; Ordoñez, R, 2013) |
| "Chemoresistance in hepatocellular carcinoma (HCC) is associated with multiple cellular responses to environmental stresses, such as nutrient deprivation and hypoxia." | 1.39 | Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. ( Fan, L; Lei, Y; Li, X; Ma, T; Sun, G; Wei, W; Zhong, F, 2013) |
| "Treatment with melatonin (10(-8)-10(-5) mol/L) alone had a dose-related inhibitory effect on cell proliferation but no cytotoxic effect on hepatoma cell lines HepG2 and Bel-7402." | 1.36 | Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines. ( Fan, LL; Fu, WZ; Ge, L; Sun, GP; Wang, H; Wang, ZG; Wei, W, 2010) |
| "Melatonin treatment also resulted in increased caspase-8 activity, although no significant change was observed in Fas-L expression." | 1.35 | Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. ( González, P; González-Gallego, J; Jorquera, F; Martín-Renedo, J; Mauriz, JL; Ruiz-Andrés, O, 2008) |
| "Acute hepatic porphyrias are risk factors for hepatocellular carcinoma." | 1.31 | Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors. ( Andant, C; Bogard, C; Deybach, JC; Faivre, J; Nordmann, Y; Puy, H; Soulé, JC, 2000) |
| "Experimental studies have showed that hepatocellular carcinoma (HCC) cells are susceptible to cytolysis of interleukin (IL)-2-activated lymphocytes." | 1.29 | Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Conti, A; Lissoni, P; Maestroni, GJ; Piperno, A; Pozzi, M; Ricci, G; Tancini, G, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.08) | 18.2507 |
| 2000's | 12 (25.00) | 29.6817 |
| 2010's | 25 (52.08) | 24.3611 |
| 2020's | 10 (20.83) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, S | 1 |
| Byun, JK | 1 |
| Kim, NY | 1 |
| Jin, J | 1 |
| Woo, H | 1 |
| Choi, YK | 1 |
| Park, KG | 1 |
| Hamed, AR | 2 |
| Yahya, SMM | 2 |
| Nabih, HK | 2 |
| Ozturk, I | 1 |
| Elbe, H | 1 |
| Bicer, Y | 1 |
| Karayakali, M | 1 |
| Onal, MO | 1 |
| Altinoz, E | 1 |
| Cruz, EMS | 1 |
| Concato, VM | 1 |
| de Morais, JMB | 1 |
| Silva, TF | 1 |
| Inoue, FSR | 1 |
| de Souza Cremer, M | 1 |
| Bidóia, DL | 1 |
| Machado, RRB | 1 |
| de Almeida Chuffa, LG | 1 |
| Mantovani, MS | 1 |
| Panis, C | 1 |
| Pavanelli, WR | 1 |
| Seiva, FRF | 1 |
| Chen, L | 1 |
| Sun, T | 1 |
| Lv, Y | 1 |
| Lu, X | 1 |
| Li, X | 3 |
| Zhang, H | 1 |
| Qian, K | 1 |
| Guo, X | 1 |
| Sun, B | 1 |
| Zhang, W | 1 |
| Zhu, L | 1 |
| Huang, J | 1 |
| Liu, Y | 2 |
| Zhao, H | 1 |
| Zhao, Y | 1 |
| Liang, B | 1 |
| Zheng, C | 1 |
| Zhou, B | 1 |
| Lu, Q | 1 |
| Liu, J | 2 |
| Fan, L | 5 |
| Wang, Y | 1 |
| Wei, W | 6 |
| Wang, H | 4 |
| Sun, G | 5 |
| Elmahallawy, EK | 1 |
| Mohamed, Y | 2 |
| Abdo, W | 1 |
| Yanai, T | 1 |
| Ao, L | 1 |
| Li, L | 1 |
| Sun, H | 1 |
| Chen, H | 1 |
| Li, Y | 2 |
| Huang, H | 1 |
| Wang, X | 2 |
| Guo, Z | 1 |
| Zhou, R | 1 |
| Huang, M | 1 |
| Zhao, Q | 1 |
| Ye, Z | 1 |
| Xu, D | 1 |
| Tang, S | 1 |
| Jiang, T | 1 |
| Cheng, L | 1 |
| Liu, Q | 1 |
| Wang, F | 1 |
| Yu, H | 1 |
| Bu, L | 1 |
| Mortezaee, K | 2 |
| Khanlarkhani, N | 1 |
| Sánchez, DI | 2 |
| González-Fernández, B | 2 |
| Crespo, I | 2 |
| San-Miguel, B | 2 |
| Álvarez, M | 1 |
| González-Gallego, J | 8 |
| Tuñón, MJ | 2 |
| Dauchy, RT | 2 |
| Wren-Dail, MA | 1 |
| Dupepe, LM | 2 |
| Hill, SM | 2 |
| Xiang, S | 1 |
| Anbalagan, M | 1 |
| Belancio, VP | 2 |
| Dauchy, EM | 2 |
| Blask, DE | 2 |
| Wang, TH | 1 |
| Hsueh, C | 1 |
| Chen, CC | 1 |
| Li, WS | 1 |
| Yeh, CT | 1 |
| Lian, JH | 1 |
| Chang, JL | 1 |
| Chen, CY | 1 |
| El-Magd, MA | 1 |
| El-Shetry, ES | 1 |
| Elsayed, SA | 1 |
| Abo Gazia, M | 1 |
| Abdel-Aleem, GA | 1 |
| Shafik, NM | 1 |
| Abdo, WS | 1 |
| El-Desouki, NI | 1 |
| Basyony, MA | 1 |
| Lorente, L | 1 |
| Rodriguez, ST | 1 |
| Sanz, P | 1 |
| Abreu-González, P | 1 |
| González-Rivero, AF | 1 |
| Pérez-Cejas, A | 1 |
| Padilla, J | 1 |
| Díaz, D | 1 |
| González, A | 1 |
| Martín, MM | 1 |
| Jiménez, A | 1 |
| Cerro, P | 1 |
| Portero, J | 1 |
| Barrera, MA | 1 |
| Ma, T | 3 |
| Zhong, F | 3 |
| Lei, Y | 1 |
| Carbajo-Pescador, S | 3 |
| Ordoñez, R | 3 |
| Benet, M | 1 |
| Jover, R | 1 |
| García-Palomo, A | 3 |
| Mauriz, JL | 6 |
| Tomov, B | 1 |
| Popov, D | 1 |
| Tomova, R | 1 |
| Vladov, N | 1 |
| Den Otter, W | 1 |
| Krastev, Z | 1 |
| Moreira, AJ | 1 |
| Cerski, CT | 1 |
| Picada, JN | 1 |
| Marroni, NP | 1 |
| Prieto-Domínguez, N | 1 |
| Fernández, A | 1 |
| Méndez-Blanco, C | 1 |
| Baulies, A | 1 |
| Garcia-Ruiz, C | 1 |
| Fernández-Checa, JC | 1 |
| de Urbina, JO | 1 |
| Lin, S | 1 |
| Hoffmann, K | 1 |
| Gao, C | 1 |
| Petrulionis, M | 1 |
| Herr, I | 1 |
| Schemmer, P | 1 |
| Martín-Renedo, J | 2 |
| Jorquera, F | 1 |
| Ruiz-Andrés, O | 1 |
| González, P | 1 |
| Ozdemir, F | 1 |
| Deniz, O | 1 |
| Kaynar, K | 1 |
| Arslan, M | 1 |
| Kavgaci, H | 1 |
| Yildiz, B | 1 |
| Aydin, F | 1 |
| Fan, LL | 1 |
| Sun, GP | 1 |
| Wang, ZG | 1 |
| Ge, L | 1 |
| Fu, WZ | 1 |
| Lin, ZY | 1 |
| Chuang, WL | 1 |
| Ooms, TG | 1 |
| Hill, CR | 1 |
| Mao, L | 1 |
| Slakey, LM | 1 |
| Piva, M | 1 |
| Filatova, NA | 1 |
| Kirpichnikova, KM | 1 |
| Aksenov, ND | 1 |
| Vakhromova, EA | 1 |
| Gamaleĭ, IA | 1 |
| Zha, L | 1 |
| Cid, MA | 1 |
| Ubeda, A | 1 |
| Hernández-Bule, ML | 1 |
| Martínez, MA | 1 |
| Trillo, MÁ | 1 |
| Steinmetz, C | 1 |
| Kashyap, A | 1 |
| Lorenz, S | 1 |
| Heise, M | 1 |
| Galle, PR | 1 |
| Strand, S | 1 |
| Hermann, R | 1 |
| Podhajsky, S | 1 |
| Jungnickel, S | 1 |
| Lerchl, A | 1 |
| Yan, JJ | 1 |
| Shen, F | 1 |
| Wang, K | 1 |
| Wu, MC | 1 |
| Gong, LH | 1 |
| Ren, DH | 1 |
| Xiong, M | 1 |
| Lu, ZQ | 1 |
| Wang, XM | 2 |
| Qin, L | 1 |
| Duan, Q | 1 |
| Chen, B | 1 |
| He, S | 1 |
| She, MH | 1 |
| Chen, BB | 1 |
| He, SS | 1 |
| Dakshayani, KB | 3 |
| Subramanian, P | 3 |
| Manivasagam, T | 1 |
| Essa, MM | 1 |
| Manoharan, S | 1 |
| Mirunalini, S | 1 |
| Pandi-Perumal, SR | 2 |
| Trakht, I | 2 |
| Cardinali, DP | 2 |
| Aldeghi, R | 1 |
| Lissoni, P | 2 |
| Barni, S | 1 |
| Ardizzoia, A | 1 |
| Tancini, G | 1 |
| Piperno, A | 1 |
| Pozzi, M | 1 |
| Ricci, G | 1 |
| Conti, A | 2 |
| Maestroni, GJ | 2 |
| Andant, C | 1 |
| Puy, H | 1 |
| Bogard, C | 1 |
| Faivre, J | 1 |
| Soulé, JC | 1 |
| Nordmann, Y | 1 |
| Deybach, JC | 1 |
| Rovelli, F | 1 |
| Malugani, F | 1 |
| Bucovec, R | 1 |
4 reviews available for melatonin and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Differentiation; Humans; Liver; Liver Neoplas | 2020 |
Melatonin application in targeting oxidative-induced liver injuries: A review.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Humans; Li | 2018 |
Human hepatocellular carcinoma: Protection by melatonin.
Topics: Antioxidants; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; En | 2018 |
3 trials available for melatonin and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study.
Topics: Adjuvants, Immunologic; Adult; Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Comb | 2002 |
Anti-angiogenic activity of melatonin in advanced cancer patients.
Topics: Adult; Aged; Bone Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; C | 2001 |
42 other studies available for melatonin and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Glycolysis; Humans; Liver Neoplasms; Mechanistic Target | 2022 |
Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations.
Topics: Anti-Inflammatory Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Doxorub | 2023 |
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation.
Topics: Acrylamide; Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury | 2023 |
Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lactates; Liver Neoplasms; Melatonin | 2023 |
Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Pro | 2023 |
Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design.
Topics: Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Humans; Hypoxia; Liver Neoplasms | 2023 |
Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway.
Topics: Activating Transcription Factor 4; Autophagy; Beclin-1; Blotting, Western; Carcinoma, Hepatocellular | 2019 |
Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, | 2020 |
Development of a novel melatonin-modified near-infrared fluorescent probe for in vivo hepatocellular carcinoma imaging.
Topics: Carcinoma, Hepatocellular; Diagnostic Imaging; Fluorescent Dyes; Humans; Liver Neoplasms; Melatonin | 2020 |
Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages.
Topics: Animals; B7-H1 Antigen; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Exosomes; Fe | 2017 |
Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Circadian Clocks; Diethylnitrosamine; Endoplas | 2018 |
Effect of Daytime Blue-enriched LED Light on the Nighttime Circadian Melatonin Inhibition of Hepatoma 7288CTC Warburg Effect and Progression.
Topics: Animals; Carcinoma, Hepatocellular; Circadian Rhythm; Disease Progression; Glycolysis; Heterografts; | 2018 |
Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction.
Topics: 3' Untranslated Regions; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferat | 2018 |
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model | 2019 |
Low Serum Melatonin Levels Prior to Liver Transplantation in Patients with Hepatocellular Carcinoma are Associated with Lower Survival after Liver Transplantation.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Female; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Live | 2019 |
Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Drug | 2013 |
Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin.
Topics: Antibiotics, Antineoplastic; Antioxidants; Carcinoma, Hepatocellular; Down-Regulation; Doxorubicin; | 2013 |
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cyclic S-Oxides | 2013 |
Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin.
Topics: Aged; alpha-Fetoproteins; BCG Vaccine; Carcinoma, Hepatocellular; Female; Humans; Immunologic Factor | 2013 |
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo | 2015 |
Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy.
Topics: Apoptosis; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplas | 2016 |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode | 2017 |
Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma.
Topics: Anthracenes; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Dru | 2017 |
Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line.
Topics: Analysis of Variance; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Cycle; | 2008 |
The effects of melatonin on human hepatoma (Hep G2) cell line.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Live | 2009 |
Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associ | 2010 |
Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines.
Topics: Amidohydrolases; Amphotericin B; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Line, Tumo | 2010 |
Eliminating animal facility light-at-night contamination and its effect on circadian regulation of rodent physiology, tumor growth, and metabolism: a challenge in the relocation of a cancer research laboratory.
Topics: Academies and Institutes; Animals; Animals, Laboratory; Blood Glucose; Breast Neoplasms; Carcinoma, | 2011 |
Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Survival; Cyclic AMP; Hep G2 Cells; Humans; Liver | 2011 |
[Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin].
Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Flow Cytometry; Humans | 2011 |
Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclooxygenase 2; Endopla | 2012 |
Antagonistic effects of a 50 Hz magnetic field and melatonin in the proliferation and differentiation of hepatocarcinoma cells.
Topics: Albumins; alpha-Fetoproteins; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Differentiation | 2012 |
Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Binding Sites; Carcinoma, Hepatocel | 2013 |
Potentiation of antiproliferative effects of tamoxifen and ethanol on mouse hepatoma cells by melatonin: possible involvement of mitogen-activated protein kinase and induction of apoptosis.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cell | 2002 |
[Melatonin in in vitro apoptosis of H22 hepatocarcinoma cells].
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Re | 2003 |
Inhibitory effect of melatonin on the growth of H22 hepatocarcinoma cells by inducing apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Flow Cytomet | 2004 |
[p53-dependent antiproliferation and apoptosis of H22 cell induced by melatonin].
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclin E; Fas L | 2004 |
Melatonin modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Liver Neoplas | 2005 |
Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cell Transfor | 2007 |
24-hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or alpha-ketoglutarate.
Topics: Alanine Transaminase; alpha-Fetoproteins; Animals; Antioxidants; Aspartate Aminotransferases; Carcin | 2008 |
Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma.
Topics: Adult; Aged; Biopterins; Carcinoma, Hepatocellular; Eosinophils; Female; Humans; Injections, Subcuta | 1994 |
Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors.
Topics: Acute Disease; Adult; Carcinoma, Hepatocellular; Cohort Studies; Female; Heme; Humans; Incidence; Li | 2000 |