Page last updated: 2024-10-19

melatonin and Carcinogenesis

melatonin has been researched along with Carcinogenesis in 29 studies

Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.

Research Excerpts

ExcerptRelevanceReference
"The risk factors of liver cancer include alcoholic liver disease, non-alcoholic fatty liver disease, disruption of melatonin levels, and dysregulated circadian rhythm."6.72Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings. ( Alpini, G; Baiocchi, L; Ceci, L; Chen, L; Francis, H; Glaser, S; Han, Y; Kennedy, L, 2021)
"The prevalence and mortality rate of colorectal cancer have been dramatically rising globally."6.66The Role of Melatonin in Colorectal Cancer. ( Dooghaie Moghadam, A; Eslami, P; Hashemi, MR; Iravani, S; Majidzadeh-A, K; Mansour-Ghanaei, A; Mansour-Ghanaei, F; Mehrvar, A; Moazzami, B, 2020)
"5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model."6.505-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014)
"The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process."5.72Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022)
"Colorectal carcinogenesis is frequently induced by hypoxia to trigger the reprogramming of cellular metabolism and gain of malignant phenotypes."5.62Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms. ( Chang, CL; Chen, CH; Chen, HH; Chiang, JY; Chu, CH; Li, YC; Yip, HK, 2021)
"By melatonin treatment this ratio was similar to control values."5.56Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis. ( Aljaser, F; Alsharidah, AS; Azmi, AS; Banu, N; Fatima, S; Khan, SA; Muqbil, I, 2020)
" In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated."5.48Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018)
"Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder."5.43Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016)
"Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration."5.42Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"The risk factors of liver cancer include alcoholic liver disease, non-alcoholic fatty liver disease, disruption of melatonin levels, and dysregulated circadian rhythm."2.72Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings. ( Alpini, G; Baiocchi, L; Ceci, L; Chen, L; Francis, H; Glaser, S; Han, Y; Kennedy, L, 2021)
"Melatonin has been reported to present numerous antitumor effects, which result in a reduced cell growth."2.72Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration. ( Antolín, I; Duarte-Olivenza, C; Herrera, F; Martín, V; Puente-Moncada, N; Reiter, RJ; Rodríguez, C; Rodríguez-Blanco, J; Sánchez-Sánchez, AM; Turos-Cabal, M, 2021)
"The prevalence and mortality rate of colorectal cancer have been dramatically rising globally."2.66The Role of Melatonin in Colorectal Cancer. ( Dooghaie Moghadam, A; Eslami, P; Hashemi, MR; Iravani, S; Majidzadeh-A, K; Mansour-Ghanaei, A; Mansour-Ghanaei, F; Mehrvar, A; Moazzami, B, 2020)
"Melatonin is an amphipathic indolamine molecule ubiquitously present in all organisms ranging from cyanobacteria to humans."2.66Melatonin: an endogenous miraculous indolamine, fights against cancer progression. ( Samanta, S, 2020)
"Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melatonin are known as kynuramines."2.55Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis. ( Bonior, J; Ceranowicz, P; Dembinski, A; Góralska, M; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porąbka, K; Pierzchalski, P; Szklarczyk, J; Warzecha, Z, 2017)
"Pancreatic cancer has fatal prognosis because of the absence of early symptoms, late diagnosis and the resistance to radio- and chemotherapy."2.50Melatonin influences pancreatic cancerogenesis. ( Jaworek, J; Leja-Szpak, A, 2014)
"5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model."2.505-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014)
"sleep and mood), immune function, cancer initiation and growth, as well as the correlation between melatonin levels and cancer risk, are hereinafter recorded and summarized."2.49Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks. ( Antoniello, N; Faliva, MA; Perna, S; Rondanelli, M, 2013)
"Non-melanoma skin cancer (NMSC) is the most common cancer in the world."1.91The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model. ( Chou, P; Dina Kuo, HC; Kong, AN; Mary Peter, R; Ramirez, CN; Sargsyan, D; Sarwar, MS; Shannar, A; Su, X; Wang, Y; Wu, R; Yang, Y; Yin, R, 2023)
"The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process."1.72Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022)
"Colorectal carcinogenesis is frequently induced by hypoxia to trigger the reprogramming of cellular metabolism and gain of malignant phenotypes."1.62Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms. ( Chang, CL; Chen, CH; Chen, HH; Chiang, JY; Chu, CH; Li, YC; Yip, HK, 2021)
"By melatonin treatment this ratio was similar to control values."1.56Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis. ( Aljaser, F; Alsharidah, AS; Azmi, AS; Banu, N; Fatima, S; Khan, SA; Muqbil, I, 2020)
"Melatonin shows promise in the treatment of lung cancer stemness and deserves further study."1.51Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β-catenin, and Twist pathways. ( Chao, CC; Chen, PC; Chiou, PC; Huang, WC; Liu, PY; Tang, CH; Yang, YC, 2019)
" In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated."1.48Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018)
"Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder."1.43Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016)
"Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration."1.42Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's15 (51.72)24.3611
2020's14 (48.28)2.80

Authors

AuthorsStudies
Pan, S1
Guo, Y1
Hong, F1
Xu, P1
Zhai, Y1
Li, YC1
Chen, CH1
Chang, CL1
Chiang, JY1
Chu, CH1
Chen, HH1
Yip, HK1
Kurhaluk, N2
Tkachenko, H1
Han, Y1
Chen, L1
Baiocchi, L1
Ceci, L1
Glaser, S1
Francis, H1
Alpini, G1
Kennedy, L1
Wong, KC1
Jayapalan, JJ1
Subramanian, P1
Ismail, MN1
Abdul-Rahman, PS1
Sarwar, MS1
Ramirez, CN1
Dina Kuo, HC1
Chou, P1
Wu, R1
Sargsyan, D1
Yang, Y1
Shannar, A1
Mary Peter, R1
Yin, R1
Wang, Y2
Su, X1
Kong, AN1
Iravani, S1
Eslami, P1
Dooghaie Moghadam, A1
Moazzami, B1
Mehrvar, A1
Hashemi, MR1
Mansour-Ghanaei, F1
Mansour-Ghanaei, A1
Majidzadeh-A, K1
Wen, YC1
Lin, YW1
Chu, CY1
Yang, YC2
Yang, SF1
Liu, YF1
Hsiao, M1
Lee, WJ1
Chien, MH1
Samanta, S1
Rodríguez, C1
Puente-Moncada, N1
Reiter, RJ2
Sánchez-Sánchez, AM1
Herrera, F1
Rodríguez-Blanco, J1
Duarte-Olivenza, C1
Turos-Cabal, M1
Antolín, I1
Martín, V1
Muqbil, I1
Fatima, S1
Azmi, AS1
Alsharidah, AS1
Khan, SA1
Aljaser, F1
Banu, N1
Esmaely, F1
Mahmoudzadeh, A1
Cheki, M1
Shirazi, A1
Doğanlar, O1
Doğanlar, ZB1
Delen, E1
Doğan, A1
Wendeu-Foyet, MG1
Menegaux, F1
Jaworek, J2
Leja-Szpak, A2
Nawrot-Porąbka, K1
Szklarczyk, J1
Kot, M1
Pierzchalski, P1
Góralska, M1
Ceranowicz, P1
Warzecha, Z1
Dembinski, A1
Bonior, J1
Kumari, R1
Rawat, K1
Kumari, A1
Shrivastava, A1
Bojková, B1
Winklewski, PJ1
Giudice, A1
Crispo, A1
Grimaldi, M1
Polo, A1
Bimonte, S1
Capunzo, M1
Amore, A1
D'Arena, G1
Cerino, P1
Budillon, A1
Botti, G1
Costantini, S1
Montella, M1
Bondy, SC1
Campbell, A1
Chiou, PC1
Chen, PC1
Liu, PY1
Huang, WC1
Chao, CC1
Tang, CH1
Wang, Q1
Sun, Z1
Du, L1
Xu, C1
Yang, B1
He, N1
Wang, J1
Ji, K1
Liu, Y1
Liu, Q1
Mirza-Aghazadeh-Attari, M1
Mohammadzadeh, A1
Adib, A1
Darband, SG1
Sadighparvar, S1
Mihanfar, A1
Majidinia, M1
Yousefi, B1
Shafabakhsh, R1
Davoodabadi, A1
Asemi, Z1
Rondanelli, M1
Faliva, MA1
Perna, S1
Antoniello, N1
Wu, KK1
Cheng, HH1
Chang, TC1
Trivedi, PP1
Jena, GB1
Tikoo, KB1
Kumar, V1
Moreira, AJ1
Ordoñez, R1
Cerski, CT1
Picada, JN1
García-Palomo, A1
Marroni, NP1
Mauriz, JL1
González-Gallego, J1

Reviews

15 reviews available for melatonin and Carcinogenesis

ArticleYear
Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota.
    Biochimica et biophysica acta. Molecular basis of disease, 2022, 01-01, Volume: 1868, Issue:1

    Topics: Apoptosis; Carcinogenesis; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Gastrointestinal

2022
Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings.
    Critical reviews in oncogenesis, 2021, Volume: 26, Issue:3

    Topics: Animals; Carcinogenesis; Circadian Rhythm; Humans; Liver Neoplasms; Mammals; Melatonin

2021
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
The Role of Melatonin in Colorectal Cancer.
    Journal of gastrointestinal cancer, 2020, Volume: 51, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Carcinogenesis; Colorectal Ne

2020
Melatonin: an endogenous miraculous indolamine, fights against cancer progression.
    Journal of cancer research and clinical oncology, 2020, Volume: 146, Issue:8

    Topics: Animals; Antioxidants; Carcinogenesis; Disease Progression; Humans; Melatonin; Neoplasms; Receptor,

2020
Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration.
    Journal of cellular physiology, 2021, Volume: 236, Issue:1

    Topics: Animals; Carcinogenesis; Cell Proliferation; Gluconeogenesis; Glucose; Glycolysis; Humans; Melatonin

2021
Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017, Volume: 26, Issue:7

    Topics: Carcinogenesis; Cell Proliferation; Chronobiology Disorders; Circadian Rhythm; Circadian Rhythm Sign

2017
Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis.
    International journal of molecular sciences, 2017, May-08, Volume: 18, Issue:5

    Topics: Animals; Carcinogenesis; Humans; Melatonin; Pancreas; Pancreatic Neoplasms; Pancreatitis; Receptors,

2017
The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis.
    Molecules (Basel, Switzerland), 2018, May-29, Volume: 23, Issue:6

    Topics: Animals; Biological Clocks; Carcinogenesis; CLOCK Proteins; Energy Metabolism; Gene Expression Regul

2018
Mechanisms Underlying Tumor Suppressive Properties of Melatonin.
    International journal of molecular sciences, 2018, Jul-27, Volume: 19, Issue:8

    Topics: Aging; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogenesis; Disease Models, Animal; Disea

2018
Melatonin-mediated regulation of autophagy: Making sense of double-edged sword in cancer.
    Journal of cellular physiology, 2019, Volume: 234, Issue:10

    Topics: Animals; Autophagy; Carcinogenesis; Cell Transformation, Neoplastic; Humans; Melatonin; Neoplasms; S

2019
Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinogenesis; Colorectal Neoplasms; Humans; Inflammation; Melatoni

2019
Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.
    Aging clinical and experimental research, 2013, Volume: 25, Issue:5

    Topics: Animals; Carcinogenesis; Humans; Melatonin; Mood Disorders; Neoplasms; Sleep Disorders, Circadian Rh

2013
Melatonin influences pancreatic cancerogenesis.
    Histology and histopathology, 2014, Volume: 29, Issue:4

    Topics: Animals; Antioxidants; Apoptosis; Carcinogenesis; Humans; Melatonin; Pancreatic Neoplasms

2014
5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.
    Journal of biomedical science, 2014, Mar-03, Volume: 21

    Topics: Carcinogenesis; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Indoles; Inflammat

2014

Trials

2 trials available for melatonin and Carcinogenesis

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology.
    Journal of cancer research and therapeutics, 2020, Volume: 16, Issue:Supplement

    Topics: Administration, Oral; Adult; Carcinogenesis; DNA Breaks, Double-Stranded; Healthy Volunteers; Histon

2020

Other Studies

13 other studies available for melatonin and Carcinogenesis

ArticleYear
Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms.
    International journal of biological sciences, 2021, Volume: 17, Issue:14

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Comb

2021
Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet.
    Scientific reports, 2022, 03-23, Volume: 12, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autophagy; Carcinogenesis; Diet, High-Fat; Female; Humans

2022
Label-free quantitative mass spectrometry analysis of the circadian proteome of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin.
    Archives of insect biochemistry and physiology, 2023, Volume: 113, Issue:2

    Topics: Animals; Carcinogenesis; Drosophila melanogaster; Drosophila Proteins; Larva; Melatonin; Proteome; T

2023
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model.
    Carcinogenesis, 2023, 08-10, Volume: 44, Issue:5

    Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens, Environmental; Epigenesis, Genetic; Melatonin;

2023
Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma.
    Journal of pineal research, 2020, Volume: 69, Issue:2

    Topics: ADAMTS1 Protein; Animals; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Humans; Kidney Ne

2020
Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis.
    Medical oncology (Northwood, London, England), 2020, Sep-29, Volume: 37, Issue:10

    Topics: Animals; Anthracenes; Antioxidants; Carcinogenesis; Carcinogens; Male; Melatonin; Oxidative Stress;

2020
The role of melatonin in angio-miR-associated inhibition of tumorigenesis and invasion in human glioblastoma tumour spheroids.
    Tissue & cell, 2021, Volume: 73

    Topics: Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neopla

2021
Amelioration of Dalton's lymphoma-induced angiogenesis by melatonin.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:6

    Topics: Animals; Blood Vessels; Carcinogenesis; Cell Movement; Cell Proliferation; Disease Models, Animal; E

2017
Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:8

    Topics: Aerobiosis; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carcinogenesis

2018
Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β-catenin, and Twist pathways.
    Environmental toxicology, 2019, Volume: 34, Issue:2

    Topics: A549 Cells; AC133 Antigen; beta Catenin; Carcinogenesis; Cell Line, Tumor; Humans; Lung Neoplasms; M

2019
Melatonin Sensitizes Human Colorectal Cancer Cells to γ-ray Ionizing Radiation In Vitro and In Vivo.
    International journal of molecular sciences, 2018, Dec-10, Volume: 19, Issue:12

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Cycle; Cell Movement; Cell Proliferation; Colorectal Neopla

2018
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis.
    Molecular carcinogenesis, 2016, Volume: 55, Issue:3

    Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Autophagy; Carcinogenesis; Carcinogens; Col

2016
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo

2015