melatonin has been researched along with Carcinogenesis in 29 studies
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
Excerpt | Relevance | Reference |
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"The risk factors of liver cancer include alcoholic liver disease, non-alcoholic fatty liver disease, disruption of melatonin levels, and dysregulated circadian rhythm." | 6.72 | Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings. ( Alpini, G; Baiocchi, L; Ceci, L; Chen, L; Francis, H; Glaser, S; Han, Y; Kennedy, L, 2021) |
"The prevalence and mortality rate of colorectal cancer have been dramatically rising globally." | 6.66 | The Role of Melatonin in Colorectal Cancer. ( Dooghaie Moghadam, A; Eslami, P; Hashemi, MR; Iravani, S; Majidzadeh-A, K; Mansour-Ghanaei, A; Mansour-Ghanaei, F; Mehrvar, A; Moazzami, B, 2020) |
"5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model." | 6.50 | 5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014) |
"The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process." | 5.72 | Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022) |
"Colorectal carcinogenesis is frequently induced by hypoxia to trigger the reprogramming of cellular metabolism and gain of malignant phenotypes." | 5.62 | Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms. ( Chang, CL; Chen, CH; Chen, HH; Chiang, JY; Chu, CH; Li, YC; Yip, HK, 2021) |
"By melatonin treatment this ratio was similar to control values." | 5.56 | Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis. ( Aljaser, F; Alsharidah, AS; Azmi, AS; Banu, N; Fatima, S; Khan, SA; Muqbil, I, 2020) |
" In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated." | 5.48 | Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018) |
"Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 5.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
"Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 5.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
"The risk factors of liver cancer include alcoholic liver disease, non-alcoholic fatty liver disease, disruption of melatonin levels, and dysregulated circadian rhythm." | 2.72 | Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings. ( Alpini, G; Baiocchi, L; Ceci, L; Chen, L; Francis, H; Glaser, S; Han, Y; Kennedy, L, 2021) |
"Melatonin has been reported to present numerous antitumor effects, which result in a reduced cell growth." | 2.72 | Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration. ( Antolín, I; Duarte-Olivenza, C; Herrera, F; Martín, V; Puente-Moncada, N; Reiter, RJ; Rodríguez, C; Rodríguez-Blanco, J; Sánchez-Sánchez, AM; Turos-Cabal, M, 2021) |
"The prevalence and mortality rate of colorectal cancer have been dramatically rising globally." | 2.66 | The Role of Melatonin in Colorectal Cancer. ( Dooghaie Moghadam, A; Eslami, P; Hashemi, MR; Iravani, S; Majidzadeh-A, K; Mansour-Ghanaei, A; Mansour-Ghanaei, F; Mehrvar, A; Moazzami, B, 2020) |
"Melatonin is an amphipathic indolamine molecule ubiquitously present in all organisms ranging from cyanobacteria to humans." | 2.66 | Melatonin: an endogenous miraculous indolamine, fights against cancer progression. ( Samanta, S, 2020) |
"Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melatonin are known as kynuramines." | 2.55 | Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis. ( Bonior, J; Ceranowicz, P; Dembinski, A; Góralska, M; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porąbka, K; Pierzchalski, P; Szklarczyk, J; Warzecha, Z, 2017) |
"Pancreatic cancer has fatal prognosis because of the absence of early symptoms, late diagnosis and the resistance to radio- and chemotherapy." | 2.50 | Melatonin influences pancreatic cancerogenesis. ( Jaworek, J; Leja-Szpak, A, 2014) |
"5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model." | 2.50 | 5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014) |
"sleep and mood), immune function, cancer initiation and growth, as well as the correlation between melatonin levels and cancer risk, are hereinafter recorded and summarized." | 2.49 | Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks. ( Antoniello, N; Faliva, MA; Perna, S; Rondanelli, M, 2013) |
"Non-melanoma skin cancer (NMSC) is the most common cancer in the world." | 1.91 | The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model. ( Chou, P; Dina Kuo, HC; Kong, AN; Mary Peter, R; Ramirez, CN; Sargsyan, D; Sarwar, MS; Shannar, A; Su, X; Wang, Y; Wu, R; Yang, Y; Yin, R, 2023) |
"The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process." | 1.72 | Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022) |
"Colorectal carcinogenesis is frequently induced by hypoxia to trigger the reprogramming of cellular metabolism and gain of malignant phenotypes." | 1.62 | Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms. ( Chang, CL; Chen, CH; Chen, HH; Chiang, JY; Chu, CH; Li, YC; Yip, HK, 2021) |
"By melatonin treatment this ratio was similar to control values." | 1.56 | Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis. ( Aljaser, F; Alsharidah, AS; Azmi, AS; Banu, N; Fatima, S; Khan, SA; Muqbil, I, 2020) |
"Melatonin shows promise in the treatment of lung cancer stemness and deserves further study." | 1.51 | Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β-catenin, and Twist pathways. ( Chao, CC; Chen, PC; Chiou, PC; Huang, WC; Liu, PY; Tang, CH; Yang, YC, 2019) |
" In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated." | 1.48 | Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018) |
"Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 1.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
"Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 1.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 15 (51.72) | 24.3611 |
2020's | 14 (48.28) | 2.80 |
Authors | Studies |
---|---|
Pan, S | 1 |
Guo, Y | 1 |
Hong, F | 1 |
Xu, P | 1 |
Zhai, Y | 1 |
Li, YC | 1 |
Chen, CH | 1 |
Chang, CL | 1 |
Chiang, JY | 1 |
Chu, CH | 1 |
Chen, HH | 1 |
Yip, HK | 1 |
Kurhaluk, N | 2 |
Tkachenko, H | 1 |
Han, Y | 1 |
Chen, L | 1 |
Baiocchi, L | 1 |
Ceci, L | 1 |
Glaser, S | 1 |
Francis, H | 1 |
Alpini, G | 1 |
Kennedy, L | 1 |
Wong, KC | 1 |
Jayapalan, JJ | 1 |
Subramanian, P | 1 |
Ismail, MN | 1 |
Abdul-Rahman, PS | 1 |
Sarwar, MS | 1 |
Ramirez, CN | 1 |
Dina Kuo, HC | 1 |
Chou, P | 1 |
Wu, R | 1 |
Sargsyan, D | 1 |
Yang, Y | 1 |
Shannar, A | 1 |
Mary Peter, R | 1 |
Yin, R | 1 |
Wang, Y | 2 |
Su, X | 1 |
Kong, AN | 1 |
Iravani, S | 1 |
Eslami, P | 1 |
Dooghaie Moghadam, A | 1 |
Moazzami, B | 1 |
Mehrvar, A | 1 |
Hashemi, MR | 1 |
Mansour-Ghanaei, F | 1 |
Mansour-Ghanaei, A | 1 |
Majidzadeh-A, K | 1 |
Wen, YC | 1 |
Lin, YW | 1 |
Chu, CY | 1 |
Yang, YC | 2 |
Yang, SF | 1 |
Liu, YF | 1 |
Hsiao, M | 1 |
Lee, WJ | 1 |
Chien, MH | 1 |
Samanta, S | 1 |
Rodríguez, C | 1 |
Puente-Moncada, N | 1 |
Reiter, RJ | 2 |
Sánchez-Sánchez, AM | 1 |
Herrera, F | 1 |
Rodríguez-Blanco, J | 1 |
Duarte-Olivenza, C | 1 |
Turos-Cabal, M | 1 |
Antolín, I | 1 |
Martín, V | 1 |
Muqbil, I | 1 |
Fatima, S | 1 |
Azmi, AS | 1 |
Alsharidah, AS | 1 |
Khan, SA | 1 |
Aljaser, F | 1 |
Banu, N | 1 |
Esmaely, F | 1 |
Mahmoudzadeh, A | 1 |
Cheki, M | 1 |
Shirazi, A | 1 |
Doğanlar, O | 1 |
Doğanlar, ZB | 1 |
Delen, E | 1 |
Doğan, A | 1 |
Wendeu-Foyet, MG | 1 |
Menegaux, F | 1 |
Jaworek, J | 2 |
Leja-Szpak, A | 2 |
Nawrot-Porąbka, K | 1 |
Szklarczyk, J | 1 |
Kot, M | 1 |
Pierzchalski, P | 1 |
Góralska, M | 1 |
Ceranowicz, P | 1 |
Warzecha, Z | 1 |
Dembinski, A | 1 |
Bonior, J | 1 |
Kumari, R | 1 |
Rawat, K | 1 |
Kumari, A | 1 |
Shrivastava, A | 1 |
Bojková, B | 1 |
Winklewski, PJ | 1 |
Giudice, A | 1 |
Crispo, A | 1 |
Grimaldi, M | 1 |
Polo, A | 1 |
Bimonte, S | 1 |
Capunzo, M | 1 |
Amore, A | 1 |
D'Arena, G | 1 |
Cerino, P | 1 |
Budillon, A | 1 |
Botti, G | 1 |
Costantini, S | 1 |
Montella, M | 1 |
Bondy, SC | 1 |
Campbell, A | 1 |
Chiou, PC | 1 |
Chen, PC | 1 |
Liu, PY | 1 |
Huang, WC | 1 |
Chao, CC | 1 |
Tang, CH | 1 |
Wang, Q | 1 |
Sun, Z | 1 |
Du, L | 1 |
Xu, C | 1 |
Yang, B | 1 |
He, N | 1 |
Wang, J | 1 |
Ji, K | 1 |
Liu, Y | 1 |
Liu, Q | 1 |
Mirza-Aghazadeh-Attari, M | 1 |
Mohammadzadeh, A | 1 |
Adib, A | 1 |
Darband, SG | 1 |
Sadighparvar, S | 1 |
Mihanfar, A | 1 |
Majidinia, M | 1 |
Yousefi, B | 1 |
Shafabakhsh, R | 1 |
Davoodabadi, A | 1 |
Asemi, Z | 1 |
Rondanelli, M | 1 |
Faliva, MA | 1 |
Perna, S | 1 |
Antoniello, N | 1 |
Wu, KK | 1 |
Cheng, HH | 1 |
Chang, TC | 1 |
Trivedi, PP | 1 |
Jena, GB | 1 |
Tikoo, KB | 1 |
Kumar, V | 1 |
Moreira, AJ | 1 |
Ordoñez, R | 1 |
Cerski, CT | 1 |
Picada, JN | 1 |
García-Palomo, A | 1 |
Marroni, NP | 1 |
Mauriz, JL | 1 |
González-Gallego, J | 1 |
15 reviews available for melatonin and Carcinogenesis
Article | Year |
---|---|
Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota.
Topics: Apoptosis; Carcinogenesis; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Gastrointestinal | 2022 |
Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings.
Topics: Animals; Carcinogenesis; Circadian Rhythm; Humans; Liver Neoplasms; Mammals; Melatonin | 2021 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
The Role of Melatonin in Colorectal Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Carcinogenesis; Colorectal Ne | 2020 |
Melatonin: an endogenous miraculous indolamine, fights against cancer progression.
Topics: Animals; Antioxidants; Carcinogenesis; Disease Progression; Humans; Melatonin; Neoplasms; Receptor, | 2020 |
Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration.
Topics: Animals; Carcinogenesis; Cell Proliferation; Gluconeogenesis; Glucose; Glycolysis; Humans; Melatonin | 2021 |
Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences.
Topics: Carcinogenesis; Cell Proliferation; Chronobiology Disorders; Circadian Rhythm; Circadian Rhythm Sign | 2017 |
Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis.
Topics: Animals; Carcinogenesis; Humans; Melatonin; Pancreas; Pancreatic Neoplasms; Pancreatitis; Receptors, | 2017 |
The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis.
Topics: Animals; Biological Clocks; Carcinogenesis; CLOCK Proteins; Energy Metabolism; Gene Expression Regul | 2018 |
Mechanisms Underlying Tumor Suppressive Properties of Melatonin.
Topics: Aging; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogenesis; Disease Models, Animal; Disea | 2018 |
Melatonin-mediated regulation of autophagy: Making sense of double-edged sword in cancer.
Topics: Animals; Autophagy; Carcinogenesis; Cell Transformation, Neoplastic; Humans; Melatonin; Neoplasms; S | 2019 |
Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; Colorectal Neoplasms; Humans; Inflammation; Melatoni | 2019 |
Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.
Topics: Animals; Carcinogenesis; Humans; Melatonin; Mood Disorders; Neoplasms; Sleep Disorders, Circadian Rh | 2013 |
Melatonin influences pancreatic cancerogenesis.
Topics: Animals; Antioxidants; Apoptosis; Carcinogenesis; Humans; Melatonin; Pancreatic Neoplasms | 2014 |
5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.
Topics: Carcinogenesis; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Indoles; Inflammat | 2014 |
2 trials available for melatonin and Carcinogenesis
Article | Year |
---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology.
Topics: Administration, Oral; Adult; Carcinogenesis; DNA Breaks, Double-Stranded; Healthy Volunteers; Histon | 2020 |
13 other studies available for melatonin and Carcinogenesis
Article | Year |
---|---|
Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Comb | 2021 |
Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autophagy; Carcinogenesis; Diet, High-Fat; Female; Humans | 2022 |
Label-free quantitative mass spectrometry analysis of the circadian proteome of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin.
Topics: Animals; Carcinogenesis; Drosophila melanogaster; Drosophila Proteins; Larva; Melatonin; Proteome; T | 2023 |
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens, Environmental; Epigenesis, Genetic; Melatonin; | 2023 |
Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma.
Topics: ADAMTS1 Protein; Animals; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Humans; Kidney Ne | 2020 |
Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis.
Topics: Animals; Anthracenes; Antioxidants; Carcinogenesis; Carcinogens; Male; Melatonin; Oxidative Stress; | 2020 |
The role of melatonin in angio-miR-associated inhibition of tumorigenesis and invasion in human glioblastoma tumour spheroids.
Topics: Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neopla | 2021 |
Amelioration of Dalton's lymphoma-induced angiogenesis by melatonin.
Topics: Animals; Blood Vessels; Carcinogenesis; Cell Movement; Cell Proliferation; Disease Models, Animal; E | 2017 |
Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis.
Topics: Aerobiosis; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carcinogenesis | 2018 |
Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β-catenin, and Twist pathways.
Topics: A549 Cells; AC133 Antigen; beta Catenin; Carcinogenesis; Cell Line, Tumor; Humans; Lung Neoplasms; M | 2019 |
Melatonin Sensitizes Human Colorectal Cancer Cells to γ-ray Ionizing Radiation In Vitro and In Vivo.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Cycle; Cell Movement; Cell Proliferation; Colorectal Neopla | 2018 |
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Autophagy; Carcinogenesis; Carcinogens; Col | 2016 |
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo | 2015 |