melatonin has been researched along with Cancer of Pancreas in 25 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we investigated how melatonin mediates insulin synthesis through endoplasmic reticulum (ER) via HuD expression in rat insulinoma INS-1E cells." | 7.79 | Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells. ( Yoo, YM, 2013) |
| " Long-term administration of melatonin alone reduced CamkIV transcript levels in INS-1 cells; however, transcript levels of Camk2d remained unchanged." | 5.40 | Calcium-signaling components in rat insulinoma β-cells (INS-1) and pancreatic islets are differentially influenced by melatonin. ( Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E, 2014) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "In this study, we investigated how melatonin mediates insulin synthesis through endoplasmic reticulum (ER) via HuD expression in rat insulinoma INS-1E cells." | 3.79 | Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells. ( Yoo, YM, 2013) |
| "Melatonin is a potent antioxidant and tissue protector against inflammation and oxidative stress." | 2.61 | Melatonin and pancreatic cancer: Current knowledge and future perspectives. ( Asemi, Z; Behnamfar, M; Mirhosseini, N; Reiter, RJ; Tamtaji, OR, 2019) |
| "Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melatonin are known as kynuramines." | 2.55 | Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis. ( Bonior, J; Ceranowicz, P; Dembinski, A; Góralska, M; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porąbka, K; Pierzchalski, P; Szklarczyk, J; Warzecha, Z, 2017) |
| "Pancreatic cancer has fatal prognosis because of the absence of early symptoms, late diagnosis and the resistance to radio- and chemotherapy." | 2.50 | Melatonin influences pancreatic cancerogenesis. ( Jaworek, J; Leja-Szpak, A, 2014) |
| "Gemcitabine is a standard chemotherapeutic agent for patients suffering from pancreatic cancer." | 1.48 | Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1). ( Bonior, J; Góralska, M; Jastrzębska, M; Jaworek, J; Leja-Szpak, A; Link-Lenczowski, P; Nawrot-Porąbka, K; Pierzchalski, P, 2018) |
| " Long-term administration of melatonin alone reduced CamkIV transcript levels in INS-1 cells; however, transcript levels of Camk2d remained unchanged." | 1.40 | Calcium-signaling components in rat insulinoma β-cells (INS-1) and pancreatic islets are differentially influenced by melatonin. ( Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E, 2014) |
| "Melatonin is an important natural oncostatic agent, and our previous studies have found its inhibitory action on tumor angiogenesis, but the mechanism remains unclear." | 1.38 | Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression. ( Cui, P; Dong, L; Peng, X; Yang, Z; Yu, M, 2012) |
| "Melatonin has antitumor activity via several mechanisms including its antiproliferative and proapoptotic effects in addition to its potent antioxidant action." | 1.38 | Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells. ( Bejarano, I; Cig, B; Espino, J; Naziroglu, M; Pariente, JA; Rodríguez, AB; Uguz, AC, 2012) |
| "When capecitabine and melatonin were combined, a well-differentiated pancreatic adenocarcinoma was observed in 10% of animals." | 1.37 | Improvement of capecitabine antitumoral activity by melatonin in pancreatic cancer. ( Arjona, A; Montilla, P; Muntané, J; Padillo, J; Perea, D; Ruiz-Rabelo, J; Túnez, I; Vázquez, R, 2011) |
| "Melatonin and/or CEL were administered during the induction, postinduction as well as during both phases." | 1.36 | Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer. ( Cruz, A; Montilla, P; Muntané, J; Padillo, FJ; Perea, MD; Ruiz-Rabelo, JF; Tasset, I; Túnez, I, 2010) |
| "Melatonin has been reported to inhibit pancreatic cancer growth in experimental studies in animals but the effect of melatonin on cultured human pancreatic carcinoma cells has not been tested." | 1.36 | Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1). ( Jaworek, J; Leja-Szpak, A; Pierzchalski, P; Reiter, RJ, 2010) |
| "In chronic pancreatitis and pancreatic cancer, progressive fibrosis with the accumulation of extracellular matrix occurs." | 1.35 | Pancreatic stellate/myofibroblast cells express G-protein-coupled melatonin receptor 1. ( Aust, S; Jäger, W; Kirschner, H; Klimpfinger, M; Thalhammer, T, 2008) |
| "Melatonin was administered during the BOP-induction phase (12 wk) and/or following the postinduction phase (12 wk)." | 1.34 | Beneficial properties of melatonin in an experimental model of pancreatic cancer. ( Cruz, A; González, R; Montilla, P; Muñoz-Villanueva, MC; Muntané, J; Padillo, FJ; Perea, MD; Romero, A; Ruiz-Rabelo, JF; Túnez, I; Vázquez, R, 2007) |
| "Melatonin was found to improve pancreatic organ function in diseased animals." | 1.33 | Melatonin modulates acid/base transport in human pancreatic carcinoma cells. ( Aust, S; Brucker, B; Graf, J; Klimpfinger, M; Thalhammer, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 18 (72.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jaworek, J | 6 |
| Leja-Szpak, A | 6 |
| Nawrot-Porąbka, K | 3 |
| Szklarczyk, J | 2 |
| Kot, M | 1 |
| Pierzchalski, P | 4 |
| Góralska, M | 3 |
| Ceranowicz, P | 1 |
| Warzecha, Z | 1 |
| Dembinski, A | 1 |
| Bonior, J | 3 |
| Fang, Z | 1 |
| Jung, KH | 1 |
| Yan, HH | 1 |
| Kim, SJ | 1 |
| Rumman, M | 1 |
| Park, JH | 1 |
| Han, B | 1 |
| Lee, JE | 1 |
| Kang, YW | 1 |
| Lim, JH | 1 |
| Hong, SS | 1 |
| Tamtaji, OR | 1 |
| Mirhosseini, N | 1 |
| Reiter, RJ | 2 |
| Behnamfar, M | 1 |
| Asemi, Z | 1 |
| Jastrzębska, M | 2 |
| Link-Lenczowski, P | 2 |
| Perfilyeva, YV | 1 |
| Ostapchuk, YO | 1 |
| Abdolla, N | 1 |
| Tleulieva, R | 1 |
| Krasnoshtanov, VC | 1 |
| Belyaev, NN | 1 |
| Yoo, YM | 1 |
| Bazwinsky-Wutschke, I | 2 |
| Mühlbauer, E | 3 |
| Albrecht, E | 2 |
| Peschke, E | 3 |
| Ju, HQ | 1 |
| Li, H | 1 |
| Tian, T | 1 |
| Lu, YX | 1 |
| Bai, L | 1 |
| Chen, LZ | 1 |
| Sheng, H | 1 |
| Mo, HY | 1 |
| Zeng, JB | 1 |
| Deng, W | 1 |
| Chiao, PJ | 1 |
| Xu, RH | 1 |
| Li, W | 1 |
| Wu, J | 1 |
| Li, Z | 1 |
| Zhou, Z | 1 |
| Zheng, C | 1 |
| Lin, L | 1 |
| Tan, B | 1 |
| Huang, M | 1 |
| Fan, M | 1 |
| Aust, S | 2 |
| Jäger, W | 1 |
| Kirschner, H | 1 |
| Klimpfinger, M | 2 |
| Thalhammer, T | 2 |
| Padillo, FJ | 2 |
| Ruiz-Rabelo, JF | 2 |
| Cruz, A | 2 |
| Perea, MD | 2 |
| Tasset, I | 1 |
| Montilla, P | 3 |
| Túnez, I | 3 |
| Muntané, J | 3 |
| Ruiz-Rabelo, J | 1 |
| Vázquez, R | 2 |
| Arjona, A | 1 |
| Perea, D | 1 |
| Padillo, J | 1 |
| Cui, P | 1 |
| Yu, M | 1 |
| Peng, X | 1 |
| Dong, L | 1 |
| Yang, Z | 1 |
| Uguz, AC | 1 |
| Cig, B | 1 |
| Espino, J | 1 |
| Bejarano, I | 1 |
| Naziroglu, M | 1 |
| Rodríguez, AB | 1 |
| Pariente, JA | 1 |
| Wolgast, S | 1 |
| Xu, C | 1 |
| Wu, A | 1 |
| Zhu, H | 1 |
| Fang, H | 1 |
| Xu, L | 1 |
| Ye, J | 1 |
| Shen, J | 1 |
| Musshoff, U | 1 |
| Csernus, VJ | 1 |
| Chankiewitz, E | 1 |
| Peschke, D | 1 |
| Muc-Wierzgon, M | 1 |
| Nowakowska-Zajdel, E | 1 |
| Zubelewicz, B | 1 |
| Wierzgon, J | 1 |
| Kokot, T | 1 |
| Klakla, K | 1 |
| Szkilnik, R | 1 |
| Wiczkowski, A | 1 |
| Brucker, B | 1 |
| Graf, J | 1 |
| González, R | 1 |
| Romero, A | 1 |
| Muñoz-Villanueva, MC | 1 |
| Konturek, SJ | 1 |
| Pawlik, WW | 1 |
4 reviews available for melatonin and Cancer of Pancreas
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis.
Topics: Animals; Carcinogenesis; Humans; Melatonin; Pancreas; Pancreatic Neoplasms; Pancreatitis; Receptors, | 2017 |
Melatonin and pancreatic cancer: Current knowledge and future perspectives.
Topics: Animals; Antineoplastic Agents; Apoptosis; Humans; Inflammation Mediators; Melatonin; Oxidative Stre | 2019 |
Melatonin influences pancreatic cancerogenesis.
Topics: Animals; Antioxidants; Apoptosis; Carcinogenesis; Humans; Melatonin; Pancreatic Neoplasms | 2014 |
Melatonin influences pancreatic cancerogenesis.
Topics: Animals; Antioxidants; Apoptosis; Carcinogenesis; Humans; Melatonin; Pancreatic Neoplasms | 2014 |
Melatonin influences pancreatic cancerogenesis.
Topics: Animals; Antioxidants; Apoptosis; Carcinogenesis; Humans; Melatonin; Pancreatic Neoplasms | 2014 |
Melatonin influences pancreatic cancerogenesis.
Topics: Animals; Antioxidants; Apoptosis; Carcinogenesis; Humans; Melatonin; Pancreatic Neoplasms | 2014 |
1 trial available for melatonin and Cancer of Pancreas
21 other studies available for melatonin and Cancer of Pancreas
| Article | Year |
|---|---|
Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway.
Topics: Cell Line, Tumor; Drug Synergism; Humans; Melatonin; Neoplasm Proteins; Niacinamide; Pancreatic Neop | 2018 |
Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1).
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Deoxycytidine; Dose-Res | 2018 |
Exogenous Melatonin Up-Regulates Expression of CD62L by Lymphocytes in Aged Mice under Inflammatory and Non-Inflammatory Conditions.
Topics: Aging; Animals; CD8-Positive T-Lymphocytes; Humans; Inflammation; Killer Cells, Natural; L-Selectin; | 2019 |
Exogenous Melatonin Up-Regulates Expression of CD62L by Lymphocytes in Aged Mice under Inflammatory and Non-Inflammatory Conditions.
Topics: Aging; Animals; CD8-Positive T-Lymphocytes; Humans; Inflammation; Killer Cells, Natural; L-Selectin; | 2019 |
Exogenous Melatonin Up-Regulates Expression of CD62L by Lymphocytes in Aged Mice under Inflammatory and Non-Inflammatory Conditions.
Topics: Aging; Animals; CD8-Positive T-Lymphocytes; Humans; Inflammation; Killer Cells, Natural; L-Selectin; | 2019 |
Exogenous Melatonin Up-Regulates Expression of CD62L by Lymphocytes in Aged Mice under Inflammatory and Non-Inflammatory Conditions.
Topics: Aging; Animals; CD8-Positive T-Lymphocytes; Humans; Inflammation; Killer Cells, Natural; L-Selectin; | 2019 |
Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells.
Topics: Animals; Cell Line, Tumor; ELAV Proteins; ELAV-Like Protein 4; Endoplasmic Reticulum Stress; Insulin | 2013 |
Calcium-signaling components in rat insulinoma β-cells (INS-1) and pancreatic islets are differentially influenced by melatonin.
Topics: Animals; Antioxidants; Base Sequence; Calcium Signaling; Cell Line, Tumor; Humans; Insulinoma; Melat | 2014 |
Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-κB activation.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; G | 2016 |
Kynuramines induce overexpression of heat shock proteins in pancreatic cancer cells via 5-hydroxytryptamine and MT1/MT2 receptors.
Topics: Cell Line, Tumor; Heat-Shock Proteins; Humans; Ketanserin; Kynuramine; Melatonin; Pancreatic Neoplas | 2015 |
Melatonin induces cell apoptosis in Mia PaCa-2 cells via the suppression of nuclear factor-κB and activation of ERK and JNK: A novel therapeutic implication for pancreatic cancer.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Surviva | 2016 |
Pancreatic stellate/myofibroblast cells express G-protein-coupled melatonin receptor 1.
Topics: Carcinoma, Pancreatic Ductal; Cell Division; Epithelial Cells; Fibrosis; Humans; Melatonin; Microsco | 2008 |
Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer.
Topics: Animals; Antioxidants; Catalase; Celecoxib; Cricetinae; Cyclooxygenase 2 Inhibitors; Glutathione; Gl | 2010 |
Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1).
Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 9; Cell L | 2010 |
Improvement of capecitabine antitumoral activity by melatonin in pancreatic cancer.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antioxidants; Capecitabine; Cricetinae; De | 2011 |
Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coculture Techniques; En | 2012 |
Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Cell Line, Tumor; | 2012 |
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, | 2012 |
Melatonin is involved in the apoptosis and necrosis of pancreatic cancer cell line SW-1990 via modulating of Bcl-2/Bax balance.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Cell | 2013 |
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP | 2002 |
Circadian fluctuations of melatonin, tumor necrosis factor-alpha and its soluble receptors in the circulation of patients with advanced gastrointestinal cancer.
Topics: Adult; Aged; Analysis of Variance; Antigens, CD; Circadian Rhythm; Colorectal Neoplasms; Enzyme-Link | 2003 |
Melatonin modulates acid/base transport in human pancreatic carcinoma cells.
Topics: Acids; Antiporters; Bicarbonates; Biological Transport; Cell Line, Tumor; Colforsin; Cyclic AMP; Gen | 2006 |
Beneficial properties of melatonin in an experimental model of pancreatic cancer.
Topics: Animals; Antioxidants; Body Weight; Cricetinae; Disease Models, Animal; Lipid Peroxides; Male; Melat | 2007 |
Melatonin stimulates HSP27 phosphorylation in human pancreatic carcinoma cells (PANC-1).
Topics: Antioxidants; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Dose-Response Relationsh | 2007 |