melatonin and Cancer of Liver studies

melatonin and Cancer of Liver

melatonin has been researched along with Cancer of Liver in 59 studies

Research Excerpts

Excerpt	Relevance	Reference
"To observe the clinical efficacy of transcatheter arterial chemoembolization (TACE) and TACE+MLT (melatonin) on inoperable advanced primary hepatocellular carcinoma."	9.10	Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. ( Shen, F; Wang, K; Wu, MC; Yan, JJ, 2002)
" The study was performed in 14 metastatic breast cancer women treated by weekly epirubicin."	9.09	Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study. ( Ardizzoia, A; Barni, S; Giani, L; Lissoni, P; Malugani, F; Mandalà, M; Paolorossi, F; Tancini, G, 1999)
"The mechanisms of resistance to the targeted drug sorafenib in the treatment of hepatocellular carcinoma (HCC) are poorly understood."	7.91	Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. ( Fan, L; Liu, J; Lu, Q; Sun, G; Wang, H; Wang, Y; Wei, W; Zhou, B, 2019)
"Melatonin has been shown to exert anticancer activity on hepatocellular carcinoma (HCC) through its antiproliferative and pro-apoptotic effect in both experimental and clinical studies, and sorafenib is the only approved drug for the systemic treatment of HCC."	7.85	Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. ( Gao, C; Herr, I; Hoffmann, K; Lin, S; Petrulionis, M; Schemmer, P, 2017)
" Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer."	7.85	Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017)
"Effects of sorafenib in hepatocellular carcinoma (HCC) are frequently transient due to tumor-acquired resistance, a phenotype that could be targeted by other molecules to reduce this adaptive response."	7.83	Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. ( Baulies, A; Fernández, A; Fernández-Checa, JC; Garcia-Ruiz, C; González-Gallego, J; Mauriz, JL; Méndez-Blanco, C; Ordóñez, R; Prieto-Domínguez, N, 2016)
"This study was to investigate whether melatonin (MLT) at pharmacologic concentrations (1 and 100 μM) had potential to influence the expressions of angiogenic (CCL2, CXCL6, IL8) and angiostatic (CXCL10) chemokine genes in two hepatocellular carcinoma (HCC) cell lines with different characteristics (cell line A, HCC24/KMUH, without susceptible to amphotericin B (AmB)-induced oxidative stress; cell line B, HCC38/KMUH, susceptible to AmB-induced oxidative stress)."	7.76	Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. ( Chuang, WL; Lin, ZY, 2010)
"The effects of melatonin on the growth of human uveal melanoma cells were studied in vitro."	7.69	Melatonin inhibits growth of cultured human uveal melanoma cells. ( Hu, DN; Roberts, JE, 1997)
"The risk factors of liver cancer include alcoholic liver disease, non-alcoholic fatty liver disease, disruption of melatonin levels, and dysregulated circadian rhythm."	6.72	Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings. ( Alpini, G; Baiocchi, L; Ceci, L; Chen, L; Francis, H; Glaser, S; Han, Y; Kennedy, L, 2021)
"Melatonin was recently reported to exert intrinsic antitumor activity in different cancers."	5.91	Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. ( Hamed, AR; Nabih, HK; Yahya, SMM, 2023)
"Melatonin is an alternative agent that may be helpful in treating HCC."	5.91	Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential. ( Bidóia, DL; Concato, VM; Cruz, EMS; de Almeida Chuffa, LG; de Morais, JMB; de Souza Cremer, M; Inoue, FSR; Machado, RRB; Mantovani, MS; Panis, C; Pavanelli, WR; Seiva, FRF; Silva, TF, 2023)
"Melatonin treatment at both doses strongly inhibited the proliferation, migration and invasion capacities of Huh7 and HepG2 cell lines, and melatonin treatment markedly induced the expression of the miRNA let7i-3p in cells."	5.48	Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction. ( Chang, JL; Chen, CC; Chen, CY; Hsueh, C; Li, WS; Lian, JH; Wang, TH; Yeh, CT, 2018)
"Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration."	5.42	Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015)
"Melatonin treatment at 50 mg/kg caused a significant reduction in liver/body weight ratios and decreased tumor volumes leading to an increase in the survival of animals."	5.39	Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. ( Boonsiri, P; Charoensuk, L; Intuyod, K; Johns, NP; Laothong, U; Pairojkul, C; Pinlaor, P; Pinlaor, S; Priprem, A, 2013)
"Apoptosis resistance in hepatocellular carcinoma (HCC) is one of the most significant factors for hepatocarcinogenesis and tumor progression, and leads to resistance to conventional chemotherapy."	5.39	Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. ( Fan, L; Ma, T; Sun, G; Wei, W; Zhong, F, 2013)
"Chemoresistance in hepatocellular carcinoma (HCC) is associated with multiple cellular responses to environmental stresses, such as nutrient deprivation and hypoxia."	5.39	Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. ( Fan, L; Lei, Y; Li, X; Ma, T; Sun, G; Wei, W; Zhong, F, 2013)
"Six years after the diagnosis of untreatable hepatocellular carcinoma, the patient remains in a good condition."	5.39	Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin. ( Den Otter, W; Krastev, Z; Popov, D; Tomov, B; Tomova, R; Vladov, N, 2013)
"Experimental studies have showed that hepatocellular carcinoma (HCC) cells are susceptible to cytolysis of interleukin (IL)-2-activated lymphocytes."	5.29	Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Conti, A; Lissoni, P; Maestroni, GJ; Piperno, A; Pozzi, M; Ricci, G; Tancini, G, 1994)
"To observe the clinical efficacy of transcatheter arterial chemoembolization (TACE) and TACE+MLT (melatonin) on inoperable advanced primary hepatocellular carcinoma."	5.10	Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. ( Shen, F; Wang, K; Wu, MC; Yan, JJ, 2002)
" The study was performed in 14 metastatic breast cancer women treated by weekly epirubicin."	5.09	Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study. ( Ardizzoia, A; Barni, S; Giani, L; Lissoni, P; Malugani, F; Mandalà, M; Paolorossi, F; Tancini, G, 1999)
"Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients."	4.40	Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
" The purpose of the current study was to reveal the possible protective effects of melatonin against AA-induced hepatic oxidative stress, hepatic inflammation, and hepatocellular proliferation in pinealectomized rats."	4.31	Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation. ( Altinoz, E; Bicer, Y; Elbe, H; Karayakali, M; Onal, MO; Ozturk, I, 2023)
"Using the gene expression profiles of four cancer cell lines from three types of gastrointestinal carcinomas before and after melatonin treatment, including gastric carcinoma (GC), colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC), differentially expressed genes (DEGs) and biological pathways influenced by melatonin were identified."	3.96	Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas. ( Ao, L; Chen, H; Guo, Z; Huang, H; Li, L; Li, Y; Sun, H; Wang, X; Zhou, R, 2020)
"The mechanisms of resistance to the targeted drug sorafenib in the treatment of hepatocellular carcinoma (HCC) are poorly understood."	3.91	Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. ( Fan, L; Liu, J; Lu, Q; Sun, G; Wang, H; Wang, Y; Wei, W; Zhou, B, 2019)
"The breast cancer xenografts nude mice treated with melatonin showed reduced tumor size (P=0."	3.88	Melatonin Differentially Modulates NF-кB Expression in Breast and Liver Cancer Cells. ( Braga, CZ; Colombo, J; Ferreira, JPS; Girol, AP; Jardim-Perassi, BV; Júnior, RP; Moschetta, MG; Sonehara, NM; Zuccari, DAPC, 2018)
" Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer."	3.85	Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. ( Crespo, I; de Urbina, JO; González-Fernández, B; González-Gallego, J; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2017)
"Melatonin has been shown to exert anticancer activity on hepatocellular carcinoma (HCC) through its antiproliferative and pro-apoptotic effect in both experimental and clinical studies, and sorafenib is the only approved drug for the systemic treatment of HCC."	3.85	Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. ( Gao, C; Herr, I; Hoffmann, K; Lin, S; Petrulionis, M; Schemmer, P, 2017)
"Effects of sorafenib in hepatocellular carcinoma (HCC) are frequently transient due to tumor-acquired resistance, a phenotype that could be targeted by other molecules to reduce this adaptive response."	3.83	Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. ( Baulies, A; Fernández, A; Fernández-Checa, JC; Garcia-Ruiz, C; González-Gallego, J; Mauriz, JL; Méndez-Blanco, C; Ordóñez, R; Prieto-Domínguez, N, 2016)
"This study was to investigate whether melatonin (MLT) at pharmacologic concentrations (1 and 100 μM) had potential to influence the expressions of angiogenic (CCL2, CXCL6, IL8) and angiostatic (CXCL10) chemokine genes in two hepatocellular carcinoma (HCC) cell lines with different characteristics (cell line A, HCC24/KMUH, without susceptible to amphotericin B (AmB)-induced oxidative stress; cell line B, HCC38/KMUH, susceptible to AmB-induced oxidative stress)."	3.76	Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. ( Chuang, WL; Lin, ZY, 2010)
"In this study, different doses (5 x 10(-5) M, 5 x 10(-4) M, 10(-3) M) of melatonin were administered into hepatocellular carcinoma cell line in vitro."	3.75	The effects of melatonin on human hepatoma (Hep G2) cell line. ( Arslan, M; Aydin, F; Deniz, O; Kavgaci, H; Kaynar, K; Ozdemir, F; Yildiz, B, 2009)
"The effects of melatonin on the growth of human uveal melanoma cells were studied in vitro."	3.69	Melatonin inhibits growth of cultured human uveal melanoma cells. ( Hu, DN; Roberts, JE, 1997)
"The risk factors of liver cancer include alcoholic liver disease, non-alcoholic fatty liver disease, disruption of melatonin levels, and dysregulated circadian rhythm."	2.72	Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings. ( Alpini, G; Baiocchi, L; Ceci, L; Chen, L; Francis, H; Glaser, S; Han, Y; Kennedy, L, 2021)
"Melatonin was given orally at 20 mg/day in the evening for at least 2 months."	2.70	Anti-angiogenic activity of melatonin in advanced cancer patients. ( Bucovec, R; Conti, A; Lissoni, P; Maestroni, GJ; Malugani, F; Rovelli, F, 2001)
"Two types of human hepatoma cell lines were used to explore the mechanism by which melatonin prevents the growth and metastasis of cancer cells in vitro."	1.91	Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design. ( Chen, L; Guo, X; Huang, J; Li, X; Liang, B; Liu, Y; Lu, X; Lv, Y; Qian, K; Sun, B; Sun, T; Zhang, H; Zhang, W; Zhao, H; Zhao, Y; Zheng, C; Zhu, L, 2023)
"Melatonin is an alternative agent that may be helpful in treating HCC."	1.91	Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential. ( Bidóia, DL; Concato, VM; Cruz, EMS; de Almeida Chuffa, LG; de Morais, JMB; de Souza Cremer, M; Inoue, FSR; Machado, RRB; Mantovani, MS; Panis, C; Pavanelli, WR; Seiva, FRF; Silva, TF, 2023)
"Melatonin was recently reported to exert intrinsic antitumor activity in different cancers."	1.91	Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. ( Hamed, AR; Nabih, HK; Yahya, SMM, 2023)
"Melatonin levels were significantly decreased in both Pnx mice and TCE-treated animals at both light regimens."	1.72	Constant light exposure and/or pinealectomy increases susceptibility to trichloroethylene-induced hepatotoxicity and liver cancer in male mice. ( Abdraboh, ME; Amer, ME; El-Missiry, MA; Elhamed, DSA; Othman, AI; Taha, AN, 2022)
"Melatonin treatment at both doses strongly inhibited the proliferation, migration and invasion capacities of Huh7 and HepG2 cell lines, and melatonin treatment markedly induced the expression of the miRNA let7i-3p in cells."	1.48	Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction. ( Chang, JL; Chen, CC; Chen, CY; Hsueh, C; Li, WS; Lian, JH; Wang, TH; Yeh, CT, 2018)
"Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration."	1.42	Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015)
" Here, we demonstrate that 1 mm melatonin dosage reduced in IL-1β-induced HepG2 cells MMP-9 gelatinase activity and inhibited cell invasion and motility through downregulation of MMP-9 gene expression and upregulation of the MMP-9-specific inhibitor tissue inhibitor of metalloproteinases (TIMP)-1."	1.40	Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells. ( Carbajo-Pescador, S; García-Palomo, A; González-Gallego, J; Mauriz, JL; Ordoñez, R; Prieto-Dominguez, N, 2014)
"Apoptosis resistance in hepatocellular carcinoma (HCC) is one of the most significant factors for hepatocarcinogenesis and tumor progression, and leads to resistance to conventional chemotherapy."	1.39	Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. ( Fan, L; Ma, T; Sun, G; Wei, W; Zhong, F, 2013)
"Melatonin treatment at 50 mg/kg caused a significant reduction in liver/body weight ratios and decreased tumor volumes leading to an increase in the survival of animals."	1.39	Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. ( Boonsiri, P; Charoensuk, L; Intuyod, K; Johns, NP; Laothong, U; Pairojkul, C; Pinlaor, P; Pinlaor, S; Priprem, A, 2013)
"Chemoresistance in hepatocellular carcinoma (HCC) is associated with multiple cellular responses to environmental stresses, such as nutrient deprivation and hypoxia."	1.39	Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. ( Fan, L; Lei, Y; Li, X; Ma, T; Sun, G; Wei, W; Zhong, F, 2013)
"Six years after the diagnosis of untreatable hepatocellular carcinoma, the patient remains in a good condition."	1.39	Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin. ( Den Otter, W; Krastev, Z; Popov, D; Tomov, B; Tomova, R; Vladov, N, 2013)
"In this study, we used human HepG2 liver cancer cells as an in vitro model to investigate the anti-angiogenic effects of melatonin."	1.39	Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. ( Benet, M; Carbajo-Pescador, S; García-Palomo, A; González-Gallego, J; Jover, R; Mauriz, JL; Ordoñez, R, 2013)
"Treatment with melatonin (10(-8)-10(-5) mol/L) alone had a dose-related inhibitory effect on cell proliferation but no cytotoxic effect on hepatoma cell lines HepG2 and Bel-7402."	1.36	Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines. ( Fan, LL; Fu, WZ; Ge, L; Sun, GP; Wang, H; Wang, ZG; Wei, W, 2010)
"Melatonin treatment were performed only during the night (between 18:00 to 09:00) in order to maintain their circadian rhythm, since serum melatonin levels are high at midnight."	1.31	Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. ( Asamoto, M; Futakuchi, M; Hagiwara, A; Imaida, K; Ogawa, K; Sano, M; Shirai, T; Tamano, S; Yoshino, H, 2000)
"Acute hepatic porphyrias are risk factors for hepatocellular carcinoma."	1.31	Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors. ( Andant, C; Bogard, C; Deybach, JC; Faivre, J; Nordmann, Y; Puy, H; Soulé, JC, 2000)
"Experimental studies have showed that hepatocellular carcinoma (HCC) cells are susceptible to cytolysis of interleukin (IL)-2-activated lymphocytes."	1.29	Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Conti, A; Lissoni, P; Maestroni, GJ; Piperno, A; Pozzi, M; Ricci, G; Tancini, G, 1994)
"Melatonin was given intramuscularly at a daily dose of 20 mg at 3."	1.28	Endocrine and immune effects of melatonin therapy in metastatic cancer patients. ( Barni, S; Crispino, S; Fraschini, F; Lissoni, P; Tancini, G, 1989)

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.69)	18.7374
1990's	6 (10.17)	18.2507
2000's	10 (16.95)	29.6817
2010's	27 (45.76)	24.3611
2020's	15 (25.42)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

1 (1.69)

18.7374

1990's

6 (10.17)

18.2507

2000's

10 (16.95)

29.6817

2010's

27 (45.76)

24.3611

2020's

15 (25.42)

2.80

Authors

Authors	Studies
Han, Y	2
Chen, L	2
Baiocchi, L	1
Ceci, L	1
Glaser, S	2
Francis, H	2
Alpini, G	2
Kennedy, L	1
Abdraboh, ME	1
El-Missiry, MA	1
Othman, AI	1
Taha, AN	1
Elhamed, DSA	1
Amer, ME	1
Lee, S	1
Byun, JK	1
Kim, NY	1
Jin, J	1
Woo, H	1
Choi, YK	1
Park, KG	1
Chowdhury, O	1
Ghosh, S	1
Das, A	1
Liu, H	1
Shang, P	1
Stepicheva, NA	1
Hose, S	1
Sinha, D	1
Chattopadhyay, S	1
Zhang, W	4
Song, G	3
Hamed, AR	2
Yahya, SMM	2
Nabih, HK	2
Ozturk, I	1
Elbe, H	1
Bicer, Y	1
Karayakali, M	1
Onal, MO	1
Altinoz, E	1
Cruz, EMS	1
Concato, VM	1
de Morais, JMB	1
Silva, TF	1
Inoue, FSR	1
de Souza Cremer, M	1
Bidóia, DL	1
Machado, RRB	1
de Almeida Chuffa, LG	1
Mantovani, MS	1
Panis, C	1
Pavanelli, WR	1
Seiva, FRF	1
Sun, T	1
Lv, Y	1
Lu, X	1
Li, X	2
Zhang, H	1
Qian, K	1
Guo, X	1
Sun, B	1
Zhu, L	1
Huang, J	1
Liu, Y	1
Zhao, H	1
Zhao, Y	1
Liang, B	1
Zheng, C	1
Zhou, B	1
Lu, Q	1
Liu, J	1
Fan, L	3
Wang, Y	1
Wei, W	5
Wang, H	3
Sun, G	3
Elmahallawy, EK	1
Mohamed, Y	2
Abdo, W	1
Yanai, T	1
Ao, L	1
Li, L	1
Sun, H	1
Chen, H	1
Li, Y	1
Huang, H	1
Wang, X	2
Guo, Z	1
Zhou, R	1
Huang, M	1
Zhao, Q	1
Ye, Z	1
Xu, D	1
Tang, S	1
Jiang, T	1
Kvietkauskas, M	1
Zitkute, V	1
Leber, B	1
Strupas, K	1
Stiegler, P	1
Schemmer, P	2
Mortezaee, K	2
Khanlarkhani, N	1
Colombo, J	1
Jardim-Perassi, BV	1
Ferreira, JPS	1
Braga, CZ	1
Sonehara, NM	1
Júnior, RP	1
Moschetta, MG	1
Girol, AP	1
Zuccari, DAPC	1
Wang, TH	1
Hsueh, C	1
Chen, CC	1
Li, WS	1
Yeh, CT	1
Lian, JH	1
Chang, JL	1
Chen, CY	1
Chao, CC	1
Chen, PC	1
Chiou, PC	1
Hsu, CJ	1
Liu, PI	1
Yang, YC	1
Reiter, RJ	1
Yang, SF	1
Tang, CH	1
El-Magd, MA	1
El-Shetry, ES	1
Elsayed, SA	1
Abo Gazia, M	1
Abdel-Aleem, GA	1
Shafik, NM	1
Abdo, WS	1
El-Desouki, NI	1
Basyony, MA	1
Lorente, L	1
Rodriguez, ST	1
Sanz, P	1
Abreu-González, P	1
González-Rivero, AF	1
Pérez-Cejas, A	1
Padilla, J	1
Díaz, D	1
González, A	1
Martín, MM	1
Jiménez, A	1
Cerro, P	1
Portero, J	1
Barrera, MA	1
Ma, T	2
Zhong, F	3
Lei, Y	1
Carbajo-Pescador, S	3
Ordoñez, R	5
Benet, M	1
Jover, R	1
García-Palomo, A	4
Mauriz, JL	6
González-Gallego, J	7
Laothong, U	1
Pinlaor, P	1
Boonsiri, P	1
Pairojkul, C	1
Priprem, A	1
Johns, NP	1
Charoensuk, L	1
Intuyod, K	1
Pinlaor, S	1
Prieto-Dominguez, N	3
Tomov, B	1
Popov, D	1
Tomova, R	1
Vladov, N	1
Den Otter, W	1
Krastev, Z	1
Talib, WH	1
Saleh, S	1
Fernández, A	2
Martínez, L	1
García-Ruiz, C	2
Fernández-Checa, JC	2
Moreira, AJ	1
Cerski, CT	1
Picada, JN	1
Marroni, NP	1
Méndez-Blanco, C	1
Baulies, A	1
Sánchez, DI	1
González-Fernández, B	1
San-Miguel, B	1
de Urbina, JO	1
Crespo, I	1
Tuñón, MJ	1
Lin, S	1
Hoffmann, K	1
Gao, C	1
Petrulionis, M	1
Herr, I	1
Bu, LJ	1
Yu, HQ	1
Fan, LL	2
Li, XQ	1
Wang, F	1
Liu, JT	1
Zhang, CJ	1
Sun, GP	2
Ozdemir, F	1
Deniz, O	1
Kaynar, K	1
Arslan, M	1
Kavgaci, H	1
Yildiz, B	1
Aydin, F	1
Wang, ZG	1
Ge, L	1
Fu, WZ	1
Lin, ZY	1
Chuang, WL	1
Dauchy, RT	1
Dupepe, LM	1
Ooms, TG	1
Dauchy, EM	1
Hill, CR	1
Mao, L	1
Belancio, VP	1
Slakey, LM	1
Hill, SM	1
Blask, DE	1
Martín-Renedo, J	1
Piva, M	1
Demorrow, S	1
Invernizzi, P	1
Jing, Q	1
Renzi, A	1
Meng, F	1
Venter, J	1
Bernuzzi, F	1
White, M	1
Lleo, A	1
Marzioni, M	1
Onori, P	1
Alvaro, D	1
Torzilli, G	1
Gaudio, E	1
Filatova, NA	1
Kirpichnikova, KM	1
Aksenov, ND	1
Vakhromova, EA	1
Gamaleĭ, IA	1
Hermann, R	1
Podhajsky, S	1
Jungnickel, S	1
Lerchl, A	1
Yan, JJ	1
Shen, F	1
Wang, K	1
Wu, MC	1
Gong, LH	1
Ren, DH	1
Xiong, M	1
Lu, ZQ	1
Wang, XM	2
Qin, L	1
Duan, Q	1
Chen, B	1
He, S	1
She, MH	1
Chen, BB	1
He, SS	1
Dakshayani, KB	1
Subramanian, P	1
Manivasagam, T	1
Essa, MM	1
Manoharan, S	1
Aldeghi, R	1
Lissoni, P	4
Barni, S	3
Ardizzoia, A	2
Tancini, G	3
Piperno, A	1
Pozzi, M	1
Ricci, G	1
Conti, A	2
Maestroni, GJ	2
Hu, DN	1
Roberts, JE	1
Imaida, K	3
Taki, M	2
Yamaguchi, T	2
Ito, T	2
Watanabe, S	2
Wake, K	1
Aimoto, A	1
Kamimura, Y	2
Ito, N	2
Shirai, T	3
Paolorossi, F	1
Mandalà, M	1
Malugani, F	2
Giani, L	1
Vician, M	1
Zeman, M	1
Herichová, I	1
Juráni, M	1
Blazícek, P	1
Matis, P	1
Hagiwara, A	1
Yoshino, H	1
Tamano, S	1
Sano, M	1
Futakuchi, M	1
Ogawa, K	1
Asamoto, M	1
Andant, C	1
Puy, H	1
Bogard, C	1
Faivre, J	1
Soulé, JC	1
Nordmann, Y	1
Deybach, JC	1
Rovelli, F	1
Bucovec, R	1
Crispino, S	1
Fraschini, F	1

Studies

Han, Y

Chen, L

Baiocchi, L

Ceci, L

Glaser, S

Francis, H

Alpini, G

Kennedy, L

Abdraboh, ME

El-Missiry, MA

Othman, AI

Taha, AN

Elhamed, DSA

Amer, ME

Lee, S

Byun, JK

Kim, NY

Jin, J

Woo, H

Choi, YK

Park, KG

Chowdhury, O

Ghosh, S

Das, A

Liu, H

Shang, P

Stepicheva, NA

Hose, S

Sinha, D

Chattopadhyay, S

Zhang, W

Song, G

Hamed, AR

Yahya, SMM

Nabih, HK

Ozturk, I

Elbe, H

Bicer, Y

Karayakali, M

Onal, MO

Altinoz, E

Cruz, EMS

Concato, VM

de Morais, JMB

Silva, TF

Inoue, FSR

de Souza Cremer, M

Bidóia, DL

Machado, RRB

de Almeida Chuffa, LG

Mantovani, MS

Panis, C

Pavanelli, WR

Seiva, FRF

Sun, T

Lv, Y

Lu, X

Li, X

Zhang, H

Qian, K

Guo, X

Sun, B

Zhu, L

Huang, J

Liu, Y

Zhao, H

Zhao, Y

Liang, B

Zheng, C

Zhou, B

Lu, Q

Liu, J

Fan, L

Wang, Y

Wei, W

Wang, H

Sun, G

Elmahallawy, EK

Mohamed, Y

Abdo, W

Yanai, T

Ao, L

Li, L

Sun, H

Chen, H

Li, Y

Huang, H

Wang, X

Guo, Z

Zhou, R

Huang, M

Zhao, Q

Ye, Z

Xu, D

Tang, S

Jiang, T

Kvietkauskas, M

Zitkute, V

Leber, B

Strupas, K

Stiegler, P

Schemmer, P

Mortezaee, K

Khanlarkhani, N

Colombo, J

Jardim-Perassi, BV

Ferreira, JPS

Braga, CZ

Sonehara, NM

Júnior, RP

Moschetta, MG

Girol, AP

Zuccari, DAPC

Wang, TH

Hsueh, C

Chen, CC

Li, WS

Yeh, CT

Lian, JH

Chang, JL

Chen, CY

Chao, CC

Chen, PC

Chiou, PC

Hsu, CJ

Liu, PI

Yang, YC

Reiter, RJ

Yang, SF

Tang, CH

El-Magd, MA

El-Shetry, ES

Elsayed, SA

Abo Gazia, M

Abdel-Aleem, GA

Shafik, NM

Abdo, WS

El-Desouki, NI

Basyony, MA

Lorente, L

Rodriguez, ST

Sanz, P

Abreu-González, P

González-Rivero, AF

Pérez-Cejas, A

Padilla, J

Díaz, D

González, A

Martín, MM

Jiménez, A

Cerro, P

Portero, J

Barrera, MA

Ma, T

Zhong, F

Lei, Y

Carbajo-Pescador, S

Ordoñez, R

Benet, M

Jover, R

García-Palomo, A

Mauriz, JL

González-Gallego, J

Laothong, U

Pinlaor, P

Boonsiri, P

Pairojkul, C

Priprem, A

Johns, NP

Charoensuk, L

Intuyod, K

Pinlaor, S

Prieto-Dominguez, N

Tomov, B

Popov, D

Tomova, R

Vladov, N

Den Otter, W

Krastev, Z

Talib, WH

Saleh, S

Fernández, A

Martínez, L

García-Ruiz, C

Fernández-Checa, JC

Moreira, AJ

Cerski, CT

Picada, JN

Marroni, NP

Méndez-Blanco, C

Baulies, A

Sánchez, DI

González-Fernández, B

San-Miguel, B

de Urbina, JO

Crespo, I

Tuñón, MJ

Lin, S

Hoffmann, K

Gao, C

Petrulionis, M

Herr, I

Bu, LJ

Yu, HQ

Fan, LL

Li, XQ

Wang, F

Liu, JT

Zhang, CJ

Sun, GP

Ozdemir, F

Deniz, O

Kaynar, K

Arslan, M

Kavgaci, H

Yildiz, B

Aydin, F

Wang, ZG

Ge, L

Fu, WZ

Lin, ZY

Chuang, WL

Dauchy, RT

Dupepe, LM

Ooms, TG

Dauchy, EM

Hill, CR

Mao, L

Belancio, VP

Slakey, LM

Hill, SM

Blask, DE

Martín-Renedo, J

Piva, M

Demorrow, S

Invernizzi, P

Jing, Q

Renzi, A

Meng, F

Venter, J

Bernuzzi, F

White, M

Lleo, A

Marzioni, M

Onori, P

Alvaro, D

Torzilli, G

Gaudio, E

Filatova, NA

Kirpichnikova, KM

Aksenov, ND

Vakhromova, EA

Gamaleĭ, IA

Hermann, R

Podhajsky, S

Jungnickel, S

Lerchl, A

Yan, JJ

Shen, F

Wang, K

Wu, MC

Gong, LH

Ren, DH

Xiong, M

Lu, ZQ

Wang, XM

Qin, L

Duan, Q

Chen, B

He, S

She, MH

Chen, BB

He, SS

Dakshayani, KB

Subramanian, P

Manivasagam, T

Essa, MM

Manoharan, S

Aldeghi, R

Lissoni, P

Barni, S

Ardizzoia, A

Tancini, G

Piperno, A

Pozzi, M

Ricci, G

Conti, A

Maestroni, GJ

Hu, DN

Roberts, JE

Imaida, K

Taki, M

Yamaguchi, T

Ito, T

Watanabe, S

Wake, K

Aimoto, A

Kamimura, Y

Ito, N

Shirai, T

Paolorossi, F

Mandalà, M

Malugani, F

Giani, L

Vician, M

Zeman, M

Herichová, I

Juráni, M

Blazícek, P

Matis, P

Hagiwara, A

Yoshino, H

Tamano, S

Sano, M

Futakuchi, M

Ogawa, K

Asamoto, M

Andant, C

Puy, H

Bogard, C

Faivre, J

Soulé, JC

Nordmann, Y

Deybach, JC

Rovelli, F

Bucovec, R

Crispino, S

Fraschini, F

Reviews

5 reviews available for melatonin and Cancer of Liver

Article	Year
Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings. Critical reviews in oncogenesis, 2021, Volume: 26, Issue:3 Topics: Animals; Carcinogenesis; Circadian Rhythm; Humans; Liver Neoplasms; Mammals; Melatonin	2021
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. Science & sports, 2023, Apr-04 Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp	2023
Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment. International journal of molecular sciences, 2020, Jun-25, Volume: 21, Issue:12 Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Differentiation; Humans; Liver; Liver Neoplas	2020
Melatonin application in targeting oxidative-induced liver injuries: A review. Journal of cellular physiology, 2018, Volume: 233, Issue:5 Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Humans; Li	2018
Human hepatocellular carcinoma: Protection by melatonin. Journal of cellular physiology, 2018, Volume: 233, Issue:10 Topics: Antioxidants; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; En	2018

Article

Year

Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings.

Critical reviews in oncogenesis, 2021, Volume: 26, Issue:3

Topics: Animals; Carcinogenesis; Circadian Rhythm; Humans; Liver Neoplasms; Mammals; Melatonin

2021

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.

Science & sports, 2023, Apr-04

Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment.

International journal of molecular sciences, 2020, Jun-25, Volume: 21, Issue:12

Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Differentiation; Humans; Liver; Liver Neoplas

2020

Melatonin application in targeting oxidative-induced liver injuries: A review.

Journal of cellular physiology, 2018, Volume: 233, Issue:5

Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Humans; Li

2018

Human hepatocellular carcinoma: Protection by melatonin.

Journal of cellular physiology, 2018, Volume: 233, Issue:10

Topics: Antioxidants; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; En

2018

Trials

4 trials available for melatonin and Cancer of Liver

Article	Year
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. Science & sports, 2023, Apr-04 Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp	2023
Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. Hepatobiliary & pancreatic diseases international : HBPD INT, 2002, Volume: 1, Issue:2 Topics: Adjuvants, Immunologic; Adult; Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Comb	2002
Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study. Journal of pineal research, 1999, Volume: 26, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Breast Neoplasms	1999
Anti-angiogenic activity of melatonin in advanced cancer patients. Neuro endocrinology letters, 2001, Volume: 22, Issue:1 Topics: Adult; Aged; Bone Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; C	2001

Article

Year

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.

Science & sports, 2023, Apr-04

Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023

Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study.

Hepatobiliary & pancreatic diseases international : HBPD INT, 2002, Volume: 1, Issue:2

Topics: Adjuvants, Immunologic; Adult; Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Comb

2002

Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study.

Journal of pineal research, 1999, Volume: 26, Issue:3

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Breast Neoplasms

1999

Anti-angiogenic activity of melatonin in advanced cancer patients.

Neuro endocrinology letters, 2001, Volume: 22, Issue:1

Topics: Adult; Aged; Bone Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; C

2001

Other Studies

51 other studies available for melatonin and Cancer of Liver

Article	Year
Constant light exposure and/or pinealectomy increases susceptibility to trichloroethylene-induced hepatotoxicity and liver cancer in male mice. Environmental science and pollution research international, 2022, Volume: 29, Issue:40 Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Neoplasms; Male; Melatonin; Mice; Pine	2022
Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity. BMB reports, 2022, Volume: 55, Issue:9 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Glycolysis; Humans; Liver Neoplasms; Mechanistic Target	2022
Sustained systemic inflammation increases autophagy and induces EMT/fibrotic changes in mouse liver cells: Protection by melatonin. Cellular signalling, 2023, Volume: 101 Topics: Animals; Autophagy; Epithelial-Mesenchymal Transition; Hepatocytes; Inflammation; Liver; Liver Cirrh	2023
A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression. Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248 Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin	2022
A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression. Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248 Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin	2022
A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression. Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248 Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin	2022
A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression. Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248 Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin	2022
Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:6 Topics: Anti-Inflammatory Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Doxorub	2023
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 174 Topics: Acrylamide; Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury	2023
Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential. Life sciences, 2023, Apr-15, Volume: 319 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lactates; Liver Neoplasms; Melatonin	2023
Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition. Scientific reports, 2023, 03-16, Volume: 13, Issue:1 Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Pro	2023
Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design. Journal of pineal research, 2023, Volume: 75, Issue:3 Topics: Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Humans; Hypoxia; Liver Neoplasms	2023
Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. International journal of biological sciences, 2019, Volume: 15, Issue:9 Topics: Activating Transcription Factor 4; Autophagy; Beclin-1; Blotting, Western; Carcinoma, Hepatocellular	2019
Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas. BMC gastroenterology, 2020, Jul-20, Volume: 20, Issue:1 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation,	2020
Development of a novel melatonin-modified near-infrared fluorescent probe for in vivo hepatocellular carcinoma imaging. Analytical methods : advancing methods and applications, 2020, 10-07, Volume: 12, Issue:37 Topics: Carcinoma, Hepatocellular; Diagnostic Imaging; Fluorescent Dyes; Humans; Liver Neoplasms; Melatonin	2020
Dietary Melatonin and Glycine Decrease Tumor Growth through Antiangiogenic Activity in Experimental Colorectal Liver Metastasis. Nutrients, 2021, Jun-13, Volume: 13, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Glycine; Leukocyte C	2021
Melatonin Differentially Modulates NF-кB Expression in Breast and Liver Cancer Cells. Anti-cancer agents in medicinal chemistry, 2018, Volume: 18, Issue:12 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Screening A	2018
Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction. International journal of molecular sciences, 2018, Sep-10, Volume: 19, Issue:9 Topics: 3' Untranslated Regions; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferat	2018
Melatonin suppresses lung cancer metastasis by inhibition of epithelial-mesenchymal transition through targeting to Twist. Clinical science (London, England : 1979), 2019, 03-15, Volume: 133, Issue:5 Topics: A549 Cells; Animals; Antineoplastic Agents; beta Catenin; Cell Movement; Epithelial-Mesenchymal Tran	2019
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 114 Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model	2019
Low Serum Melatonin Levels Prior to Liver Transplantation in Patients with Hepatocellular Carcinoma are Associated with Lower Survival after Liver Transplantation. International journal of molecular sciences, 2019, Apr-05, Volume: 20, Issue:7 Topics: Adult; Aged; Carcinoma, Hepatocellular; Female; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Live	2019
Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. Journal of pineal research, 2013, Volume: 55, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Drug	2013
Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. Journal of pineal research, 2013, Volume: 55, Issue:2 Topics: Antibiotics, Antineoplastic; Antioxidants; Carcinoma, Hepatocellular; Down-Regulation; Doxorubicin;	2013
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. British journal of cancer, 2013, Jul-09, Volume: 109, Issue:1 Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cyclic S-Oxides	2013
Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. Journal of pineal research, 2013, Volume: 55, Issue:3 Topics: Animals; Antioxidants; Cholangiocarcinoma; Cricetinae; Dimethylnitrosamine; DNA Fragmentation; DNA,	2013
Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells. Journal of pineal research, 2014, Volume: 56, Issue:1 Topics: Analysis of Variance; Cell Movement; Gene Expression; Hep G2 Cells; Humans; Interleukin-1beta; Liver	2014
Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin. Anticancer research, 2013, Volume: 33, Issue:10 Topics: Aged; alpha-Fetoproteins; BCG Vaccine; Carcinoma, Hepatocellular; Female; Humans; Immunologic Factor	2013
Propionibacterium acnes Augments Antitumor, Anti-Angiogenesis and Immunomodulatory Effects of Melatonin on Breast Cancer Implanted in Mice. PloS one, 2015, Volume: 10, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Colorimetry; Female; Huma	2015
Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells. Journal of pineal research, 2015, Volume: 59, Issue:2 Topics: Apoptosis; Autophagy; Ceramides; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver	2015
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. PloS one, 2015, Volume: 10, Issue:12 Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo	2015
Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. Journal of pineal research, 2016, Volume: 61, Issue:3 Topics: Apoptosis; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplas	2016
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. Journal of pineal research, 2017, Volume: 62, Issue:1 Topics: Animals; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode	2017
Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. Journal of pineal research, 2017, Volume: 62, Issue:3 Topics: Anthracenes; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Dru	2017
Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World journal of gastroenterology, 2017, Feb-14, Volume: 23, Issue:6 Topics: Activating Transcription Factor 6; Antioxidants; Apoptosis; bcl-2-Associated X Protein; CCAAT-Enhanc	2017
The effects of melatonin on human hepatoma (Hep G2) cell line. Bratislavske lekarske listy, 2009, Volume: 110, Issue:5 Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Live	2009
Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines. World journal of gastroenterology, 2010, Mar-28, Volume: 16, Issue:12 Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associ	2010
Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2010, Volume: 64, Issue:10 Topics: Amidohydrolases; Amphotericin B; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Line, Tumo	2010
Eliminating animal facility light-at-night contamination and its effect on circadian regulation of rodent physiology, tumor growth, and metabolism: a challenge in the relocation of a cancer research laboratory. Journal of the American Association for Laboratory Animal Science : JAALAS, 2011, Volume: 50, Issue:3 Topics: Academies and Institutes; Animals; Animals, Laboratory; Blood Glucose; Breast Neoplasms; Carcinoma,	2011
Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor. Journal of pineal research, 2011, Volume: 51, Issue:4 Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Survival; Cyclic AMP; Hep G2 Cells; Humans; Liver	2011
Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 301, Issue:4 Topics: Acetylserotonin O-Methyltransferase; Animals; Apoptosis; Arylalkylamine N-Acetyltransferase; Autocri	2011
[Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin]. Tsitologiia, 2011, Volume: 53, Issue:5 Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Flow Cytometry; Humans	2011
Potentiation of antiproliferative effects of tamoxifen and ethanol on mouse hepatoma cells by melatonin: possible involvement of mitogen-activated protein kinase and induction of apoptosis. Journal of pineal research, 2002, Volume: 33, Issue:1 Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cell	2002
[Melatonin in in vitro apoptosis of H22 hepatocarcinoma cells]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2003, Volume: 25, Issue:6 Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Re	2003
Inhibitory effect of melatonin on the growth of H22 hepatocarcinoma cells by inducing apoptosis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2004, Volume: 24, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Flow Cytomet	2004
[p53-dependent antiproliferation and apoptosis of H22 cell induced by melatonin]. Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:7 Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclin E; Fas L	2004
Melatonin modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2005, Aug-12, Volume: 8, Issue:2 Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Liver Neoplas	2005
Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:2 Topics: Adult; Aged; Biopterins; Carcinoma, Hepatocellular; Eosinophils; Female; Humans; Injections, Subcuta	1994
Melatonin inhibits growth of cultured human uveal melanoma cells. Melanoma research, 1997, Volume: 7, Issue:1 Topics: Bromodeoxyuridine; Cell Division; Humans; Liver Neoplasms; Melanoma; Melatonin; Tumor Cells, Culture	1997
Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay. Carcinogenesis, 1998, Volume: 19, Issue:2 Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Corticosterone; Diethylnitrosamine; Electromagnet	1998
The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a medium-term liver bioassay. Japanese journal of cancer research : Gann, 1998, Volume: 89, Issue:10 Topics: Adrenocorticotropic Hormone; Animals; Carcinogenicity Tests; Corticosterone; Electromagnetic Fields;	1998
Melatonin content in plasma and large intestine of patients with colorectal carcinoma before and after surgery. Journal of pineal research, 1999, Volume: 27, Issue:3 Topics: Aged; Circadian Rhythm; Colon; Colonic Neoplasms; Female; Humans; Hydroxyindoleacetic Acid; Intestin	1999
Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. Cancer letters, 2000, Jul-03, Volume: 155, Issue:1 Topics: Adrenocorticotropic Hormone; Alkylating Agents; Animals; Biological Assay; Body Weight; Bromodeoxyur	2000
Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors. Journal of hepatology, 2000, Volume: 32, Issue:6 Topics: Acute Disease; Adult; Carcinoma, Hepatocellular; Cohort Studies; Female; Heme; Humans; Incidence; Li	2000
Endocrine and immune effects of melatonin therapy in metastatic cancer patients. European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:5 Topics: Adenocarcinoma; Aged; B-Lymphocytes; beta-Endorphin; Female; Growth Hormone; Humans; Insulin-Like Gr	1989

Article

Year

Constant light exposure and/or pinealectomy increases susceptibility to trichloroethylene-induced hepatotoxicity and liver cancer in male mice.

Environmental science and pollution research international, 2022, Volume: 29, Issue:40

Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Neoplasms; Male; Melatonin; Mice; Pine

2022

Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity.

BMB reports, 2022, Volume: 55, Issue:9

Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Glycolysis; Humans; Liver Neoplasms; Mechanistic Target

2022

Sustained systemic inflammation increases autophagy and induces EMT/fibrotic changes in mouse liver cells: Protection by melatonin.

Cellular signalling, 2023, Volume: 101

Topics: Animals; Autophagy; Epithelial-Mesenchymal Transition; Hepatocytes; Inflammation; Liver; Liver Cirrh

2023

A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression.

Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248

Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin

2022

A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression.

Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248

Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin

2022

A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression.

Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248

Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin

2022

A comprehensive analysis-based study of triphenyl phosphate-environmental explanation of glioma progression.

Ecotoxicology and environmental safety, 2022, Dec-15, Volume: 248

Topics: Flame Retardants; Glioma; Humans; Liver Neoplasms; Male; Melatonin

2022

Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations.

Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:6

Topics: Anti-Inflammatory Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Doxorub

2023

Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 174

Topics: Acrylamide; Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury

2023

Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential.

Life sciences, 2023, Apr-15, Volume: 319

Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lactates; Liver Neoplasms; Melatonin

2023

Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition.

Scientific reports, 2023, 03-16, Volume: 13, Issue:1

Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Pro

2023

Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design.

Journal of pineal research, 2023, Volume: 75, Issue:3

Topics: Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Humans; Hypoxia; Liver Neoplasms

2023

Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway.

International journal of biological sciences, 2019, Volume: 15, Issue:9

Topics: Activating Transcription Factor 4; Autophagy; Beclin-1; Blotting, Western; Carcinoma, Hepatocellular

2019

Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas.

BMC gastroenterology, 2020, Jul-20, Volume: 20, Issue:1

Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation,

2020

Development of a novel melatonin-modified near-infrared fluorescent probe for in vivo hepatocellular carcinoma imaging.

Analytical methods : advancing methods and applications, 2020, 10-07, Volume: 12, Issue:37

Topics: Carcinoma, Hepatocellular; Diagnostic Imaging; Fluorescent Dyes; Humans; Liver Neoplasms; Melatonin

2020

Dietary Melatonin and Glycine Decrease Tumor Growth through Antiangiogenic Activity in Experimental Colorectal Liver Metastasis.

Nutrients, 2021, Jun-13, Volume: 13, Issue:6

Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Glycine; Leukocyte C

2021

Melatonin Differentially Modulates NF-кB Expression in Breast and Liver Cancer Cells.

Anti-cancer agents in medicinal chemistry, 2018, Volume: 18, Issue:12

Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Screening A

2018

Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction.

International journal of molecular sciences, 2018, Sep-10, Volume: 19, Issue:9

Topics: 3' Untranslated Regions; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferat

2018

Melatonin suppresses lung cancer metastasis by inhibition of epithelial-mesenchymal transition through targeting to Twist.

Clinical science (London, England : 1979), 2019, 03-15, Volume: 133, Issue:5

Topics: A549 Cells; Animals; Antineoplastic Agents; beta Catenin; Cell Movement; Epithelial-Mesenchymal Tran

2019

Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 114

Topics: alpha-Fetoproteins; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Model

2019

Low Serum Melatonin Levels Prior to Liver Transplantation in Patients with Hepatocellular Carcinoma are Associated with Lower Survival after Liver Transplantation.

International journal of molecular sciences, 2019, Apr-05, Volume: 20, Issue:7

Topics: Adult; Aged; Carcinoma, Hepatocellular; Female; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Live

2019

Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP.

Journal of pineal research, 2013, Volume: 55, Issue:2

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Drug

2013

Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin.

Journal of pineal research, 2013, Volume: 55, Issue:2

Topics: Antibiotics, Antineoplastic; Antioxidants; Carcinoma, Hepatocellular; Down-Regulation; Doxorubicin;

2013

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

British journal of cancer, 2013, Jul-09, Volume: 109, Issue:1

Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cyclic S-Oxides

2013

Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters.

Journal of pineal research, 2013, Volume: 55, Issue:3

Topics: Animals; Antioxidants; Cholangiocarcinoma; Cricetinae; Dimethylnitrosamine; DNA Fragmentation; DNA,

2013

Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells.

Journal of pineal research, 2014, Volume: 56, Issue:1

Topics: Analysis of Variance; Cell Movement; Gene Expression; Hep G2 Cells; Humans; Interleukin-1beta; Liver

2014

Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin.

Anticancer research, 2013, Volume: 33, Issue:10

Topics: Aged; alpha-Fetoproteins; BCG Vaccine; Carcinoma, Hepatocellular; Female; Humans; Immunologic Factor

2013

Propionibacterium acnes Augments Antitumor, Anti-Angiogenesis and Immunomodulatory Effects of Melatonin on Breast Cancer Implanted in Mice.

PloS one, 2015, Volume: 10, Issue:4

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Colorimetry; Female; Huma

2015

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells.

Journal of pineal research, 2015, Volume: 59, Issue:2

Topics: Apoptosis; Autophagy; Ceramides; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver

2015

Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.

PloS one, 2015, Volume: 10, Issue:12

Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo

2015

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy.

Journal of pineal research, 2016, Volume: 61, Issue:3

Topics: Apoptosis; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplas

2016

Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.

Journal of pineal research, 2017, Volume: 62, Issue:1

Topics: Animals; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Mode

2017

Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma.

Journal of pineal research, 2017, Volume: 62, Issue:3

Topics: Anthracenes; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Dru

2017

Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation.

World journal of gastroenterology, 2017, Feb-14, Volume: 23, Issue:6

Topics: Activating Transcription Factor 6; Antioxidants; Apoptosis; bcl-2-Associated X Protein; CCAAT-Enhanc

2017

The effects of melatonin on human hepatoma (Hep G2) cell line.

Bratislavske lekarske listy, 2009, Volume: 110, Issue:5

Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Live

2009

Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines.

World journal of gastroenterology, 2010, Mar-28, Volume: 16, Issue:12

Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associ

2010

Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2010, Volume: 64, Issue:10

Topics: Amidohydrolases; Amphotericin B; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Line, Tumo

2010

Eliminating animal facility light-at-night contamination and its effect on circadian regulation of rodent physiology, tumor growth, and metabolism: a challenge in the relocation of a cancer research laboratory.

Journal of the American Association for Laboratory Animal Science : JAALAS, 2011, Volume: 50, Issue:3

Topics: Academies and Institutes; Animals; Animals, Laboratory; Blood Glucose; Breast Neoplasms; Carcinoma,

2011

Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor.

Journal of pineal research, 2011, Volume: 51, Issue:4

Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Survival; Cyclic AMP; Hep G2 Cells; Humans; Liver

2011

Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth.

American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 301, Issue:4

Topics: Acetylserotonin O-Methyltransferase; Animals; Apoptosis; Arylalkylamine N-Acetyltransferase; Autocri

2011

[Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin].

Tsitologiia, 2011, Volume: 53, Issue:5

Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Flow Cytometry; Humans

2011

Potentiation of antiproliferative effects of tamoxifen and ethanol on mouse hepatoma cells by melatonin: possible involvement of mitogen-activated protein kinase and induction of apoptosis.

Journal of pineal research, 2002, Volume: 33, Issue:1

Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cell

2002

[Melatonin in in vitro apoptosis of H22 hepatocarcinoma cells].

Zhonghua zhong liu za zhi [Chinese journal of oncology], 2003, Volume: 25, Issue:6

Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Re

2003

Inhibitory effect of melatonin on the growth of H22 hepatocarcinoma cells by inducing apoptosis.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2004, Volume: 24, Issue:1

Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Flow Cytomet

2004

[p53-dependent antiproliferation and apoptosis of H22 cell induced by melatonin].

Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:7

Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclin E; Fas L

2004

Melatonin modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine induced hepatocarcinogenesis in rats.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2005, Aug-12, Volume: 8, Issue:2

Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; Liver Neoplas

2005

Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma.

European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:2

Topics: Adult; Aged; Biopterins; Carcinoma, Hepatocellular; Eosinophils; Female; Humans; Injections, Subcuta

1994

Melatonin inhibits growth of cultured human uveal melanoma cells.

Melanoma research, 1997, Volume: 7, Issue:1

Topics: Bromodeoxyuridine; Cell Division; Humans; Liver Neoplasms; Melanoma; Melatonin; Tumor Cells, Culture

1997

Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay.

Carcinogenesis, 1998, Volume: 19, Issue:2

Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Corticosterone; Diethylnitrosamine; Electromagnet

1998

The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a medium-term liver bioassay.

Japanese journal of cancer research : Gann, 1998, Volume: 89, Issue:10

Topics: Adrenocorticotropic Hormone; Animals; Carcinogenicity Tests; Corticosterone; Electromagnetic Fields;

1998

Melatonin content in plasma and large intestine of patients with colorectal carcinoma before and after surgery.

Journal of pineal research, 1999, Volume: 27, Issue:3

Topics: Aged; Circadian Rhythm; Colon; Colonic Neoplasms; Female; Humans; Hydroxyindoleacetic Acid; Intestin

1999

Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.

Cancer letters, 2000, Jul-03, Volume: 155, Issue:1

Topics: Adrenocorticotropic Hormone; Alkylating Agents; Animals; Biological Assay; Body Weight; Bromodeoxyur

2000

Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors.

Journal of hepatology, 2000, Volume: 32, Issue:6

Topics: Acute Disease; Adult; Carcinoma, Hepatocellular; Cohort Studies; Female; Heme; Humans; Incidence; Li

2000

Endocrine and immune effects of melatonin therapy in metastatic cancer patients.

European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:5

Topics: Adenocarcinoma; Aged; B-Lymphocytes; beta-Endorphin; Female; Growth Hormone; Humans; Insulin-Like Gr

1989