melatonin has been researched along with Cancer of Head in 18 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Included studies showed a statistically significant improvement in mucositis severity score for all antioxidants except melatonin." | 5.22 | Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses. ( Al-Eryani, K; Emperumal, CP; Enciso, R; Karimyan, N; Raza, A; Watters, A, 2022) |
| "Treatment with melatonin oral gel showed a consistent trend to lower incidence and shorter SOM duration and shorter duration of UOM." | 3.01 | Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment. ( Bosser, R; Cascallar, L; Escames, G; Farré, N; Giralt, J; Gómez-Millán, J; Grima, P; Lanzuela, M; Lozano, A; Marruecos, J; Mesía, R; Morera, R; Planas, I; Rubió, J; Tarragó, C; Valentí, V; Vázquez-Masedo, MG, 2021) |
| "92." | 2.94 | Efficacy of Melatonin in prevention of radiation-induced oral mucositis: A randomized clinical trial. ( Abdelrahman, H; Elsabagh, HH; Elsaka, RO; Mahmoud, SA; Moussa, E, 2020) |
| "Thirty-nine head and neck cancer patients receiving concurrent chemoradiation (5 days/week of radiation plus chemotherapy three or six cycles)." | 2.84 | Beneficial Effects of Adjuvant Melatonin in Minimizing Oral Mucositis Complications in Head and Neck Cancer Patients Receiving Concurrent Chemoradiation. ( Hurst, C; Johns, J; Johns, NP; Khuayjarernpanishk, T; Onseng, K; Priprem, A; Subongkot, S, 2017) |
| "Melatonin (MLT) has been proven to counteract chemotherapy toxicity, by acting as an anti-oxidant agent, and to promote apoptosis of cancer cells, so enhancing chemotherapy cytotoxicity." | 2.69 | Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. ( Ardizzoia, A; Barni, S; Lissoni, P; Longarini, R; Malugani, F; Mandalà, M; Paolorossi, F; Tancini, G; Vaghi, M, 1999) |
| "Oral squamous cell carcinomas are one of the most common cancers worldwide with aggressive behavior and poor prognosis." | 1.91 | Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS. ( Choi, WS; Li, X; Su, Y; Tao, Z; Wang, C; Wang, L; Zhu, W, 2023) |
| "Melatonin has been shown to have oncostatic effects in different types of cancers." | 1.91 | Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress. ( Acuña-Castroviejo, D; Carriel, V; Escames, G; Fernández-Gil, BI; Fernández-Martínez, J; Florido, J; García-Tárraga, P; Garcia-Verdugo, JM; González-García, P; Guerra-Librero, A; López-Rodríguez, A; Martinez-Ruiz, L; Oppel, F; Rodriguez-Santana, C; Rusanova, I; Sánchez-Porras, D; Sudhoff, H; Ten-Steve, A, 2023) |
| "Melatonin receptors can inhibit breast and prostate cancers; however, little is known regarding their effects on oral squamous cell carcinoma." | 1.72 | Effects of melatonin receptor expression on prognosis and survival in oral squamous cell carcinoma patients. ( Hwang, DS; Jang, MA; Kim, GC; Kim, UK; Park, HK; Ryu, MH, 2022) |
| "The prevalence of head and neck squamous cell carcinoma (HNSCC) has continued to rise for decades." | 1.72 | Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics. ( Ahn, JS; Kang, MJ; Kim, HS; Kim, YH; Lee, D; Oh, JM; Oh, SJ; Seo, Y; Shin, YY; Song, MH; Sung, ES, 2022) |
| "In addition, MTHFD1L promoted HNSCC progression in vitro and in vivo and reversed the oncostatic effects of exogenous melatonin." | 1.62 | Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis. ( Cui, L; Hu, S; Jin, Z; Wang, H; Yang, SF; Zhao, X, 2021) |
| "Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway." | 1.48 | Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. ( Acuña-Castroviejo, D; Carriel, V; Diaz-Casado, ME; Escames, G; Fernandez-Gil, BI; Florido, J; García-López, S; Guerra-Librero, A; López, LC; Martinez-Ruiz, L; Mendivil-Perez, M; Nieto, A; Ortega-Arellano, H; Reiter, RJ; Rusanova, I; Shen, YQ; Soto-Mercado, V, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 13 (72.22) | 2.80 |
| Authors | Studies |
|---|---|
| Park, HK | 1 |
| Ryu, MH | 1 |
| Hwang, DS | 1 |
| Kim, GC | 1 |
| Jang, MA | 1 |
| Kim, UK | 1 |
| Cui, L | 1 |
| Zhao, X | 1 |
| Jin, Z | 1 |
| Wang, H | 2 |
| Yang, SF | 1 |
| Hu, S | 1 |
| Shigeishi, H | 1 |
| Yokoyama, S | 1 |
| Murodumi, H | 1 |
| Sakuma, M | 1 |
| Fukada, S | 1 |
| Okuda, S | 1 |
| Yamakado, N | 1 |
| Ono, S | 1 |
| Takechi, M | 1 |
| Ohta, K | 1 |
| Shin, YY | 1 |
| Seo, Y | 1 |
| Oh, SJ | 1 |
| Ahn, JS | 1 |
| Song, MH | 1 |
| Kang, MJ | 1 |
| Oh, JM | 1 |
| Lee, D | 1 |
| Kim, YH | 1 |
| Sung, ES | 1 |
| Kim, HS | 1 |
| Luo, X | 1 |
| Chen, Y | 1 |
| Tang, H | 1 |
| Jiang, E | 1 |
| Shao, Z | 1 |
| Liu, K | 1 |
| Zhou, X | 1 |
| Shang, Z | 1 |
| Raza, A | 1 |
| Karimyan, N | 1 |
| Watters, A | 1 |
| Emperumal, CP | 1 |
| Al-Eryani, K | 1 |
| Enciso, R | 1 |
| Wang, L | 2 |
| Wang, C | 2 |
| Tao, Z | 2 |
| Zhu, W | 2 |
| Su, Y | 2 |
| Choi, WS | 2 |
| Li, X | 1 |
| Martinez-Ruiz, L | 3 |
| Florido, J | 3 |
| Rodriguez-Santana, C | 2 |
| López-Rodríguez, A | 2 |
| Guerra-Librero, A | 2 |
| Fernández-Gil, BI | 2 |
| García-Tárraga, P | 1 |
| Garcia-Verdugo, JM | 1 |
| Oppel, F | 1 |
| Sudhoff, H | 1 |
| Sánchez-Porras, D | 1 |
| Ten-Steve, A | 1 |
| Fernández-Martínez, J | 1 |
| González-García, P | 1 |
| Rusanova, I | 2 |
| Acuña-Castroviejo, D | 3 |
| Carriel, V | 2 |
| Escames, G | 4 |
| Cela, O | 1 |
| Capitanio, N | 1 |
| Ramírez-Casas, Y | 1 |
| Elsabagh, HH | 1 |
| Moussa, E | 1 |
| Mahmoud, SA | 1 |
| Elsaka, RO | 1 |
| Abdelrahman, H | 1 |
| Aras, S | 1 |
| Tanzer, İO | 1 |
| Sayir, N | 1 |
| Keleş, MS | 1 |
| Özgeriş, FB | 1 |
| Lozano, A | 1 |
| Marruecos, J | 1 |
| Rubió, J | 1 |
| Farré, N | 1 |
| Gómez-Millán, J | 1 |
| Morera, R | 1 |
| Planas, I | 1 |
| Lanzuela, M | 1 |
| Vázquez-Masedo, MG | 1 |
| Cascallar, L | 1 |
| Giralt, J | 1 |
| Valentí, V | 1 |
| Grima, P | 1 |
| Bosser, R | 1 |
| Tarragó, C | 1 |
| Mesía, R | 1 |
| Onseng, K | 1 |
| Johns, NP | 1 |
| Khuayjarernpanishk, T | 1 |
| Subongkot, S | 1 |
| Priprem, A | 1 |
| Hurst, C | 1 |
| Johns, J | 1 |
| Fan, T | 1 |
| Pi, H | 1 |
| Li, M | 1 |
| Ren, Z | 1 |
| He, Z | 1 |
| Zhu, F | 1 |
| Tian, L | 1 |
| Tu, M | 1 |
| Xie, J | 1 |
| Liu, M | 1 |
| Li, Y | 1 |
| Tan, M | 1 |
| Li, G | 1 |
| Qing, W | 1 |
| Reiter, RJ | 2 |
| Yu, Z | 1 |
| Wu, H | 1 |
| Zhou, Z | 1 |
| Shen, YQ | 1 |
| García-López, S | 1 |
| Mendivil-Perez, M | 1 |
| Soto-Mercado, V | 1 |
| Ortega-Arellano, H | 1 |
| Diaz-Casado, ME | 1 |
| Nieto, A | 1 |
| López, LC | 1 |
| Di Bella, G | 1 |
| Colori, B | 1 |
| Lissoni, P | 1 |
| Barni, S | 1 |
| Mandalà, M | 1 |
| Ardizzoia, A | 1 |
| Paolorossi, F | 1 |
| Vaghi, M | 1 |
| Longarini, R | 1 |
| Malugani, F | 1 |
| Tancini, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for melatonin and Cancer of Head
| Article | Year |
|---|---|
Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses.
Topics: Adult; Antioxidants; Curcumin; Head and Neck Neoplasms; Humans; Melatonin; Mucositis; Propolis; Sily | 2022 |
4 trials available for melatonin and Cancer of Head
| Article | Year |
|---|---|
Efficacy of Melatonin in prevention of radiation-induced oral mucositis: A randomized clinical trial.
Topics: Antioxidants; Head and Neck Neoplasms; Humans; Melatonin; Radiation Injuries; Saliva; Stomatitis | 2020 |
Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antioxidants; Cetuximab | 2021 |
Beneficial Effects of Adjuvant Melatonin in Minimizing Oral Mucositis Complications in Head and Neck Cancer Patients Receiving Concurrent Chemoradiation.
Topics: Antioxidants; Chemoradiotherapy; Female; Head and Neck Neoplasms; Humans; Male; Melatonin; Middle Ag | 2017 |
Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dr | 1999 |
13 other studies available for melatonin and Cancer of Head
| Article | Year |
|---|---|
Effects of melatonin receptor expression on prognosis and survival in oral squamous cell carcinoma patients.
Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Lymphatic Metastas | 2022 |
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis.
Topics: Aminohydrolases; Cell Line, Tumor; Formate-Tetrahydrofolate Ligase; Formates; Gene Expression Regula | 2021 |
Melatonin enhances cisplatin-induced cell death through inhibition of DERL1 in mesenchymal-like CD44
Topics: Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Gene Expressi | 2022 |
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.
Topics: Cell Line, Tumor; Head and Neck Neoplasms; Humans; Melatonin; Mitochondrial Dynamics; Neoplastic Ste | 2022 |
Melatonin inhibits EMT and PD-L1 expression through the ERK1/2/FOSL1 pathway and regulates anti-tumor immunity in HNSCC.
Topics: Animals; B7-H1 Antigen; Epithelial-Mesenchymal Transition; Head and Neck Neoplasms; MAP Kinase Signa | 2022 |
Tumor-associated macrophages facilitate oral squamous cell carcinomas migration and invasion by MIF/NLRP3/IL-1β circuit: A crosstalk interrupted by melatonin.
Topics: Animals; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Intramolecular Oxidoreductases; | 2023 |
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS.
Topics: Animals; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Disease Models, Animal; Ferroptosis; Head a | 2023 |
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Head and Neck Neoplasms; Heterografts; Humans | 2023 |
The Relationship between Clock Genes, Sirtuin 1, and Mitochondrial Activity in Head and Neck Squamous Cell Cancer: Effects of Melatonin Treatment.
Topics: Circadian Rhythm; Head and Neck Neoplasms; Humans; Melatonin; Neoplasms, Squamous Cell; Sirtuin 1; S | 2023 |
Radiobiological comparison of flattening filter (FF) and flattening filter-free (FFF) beam in rat laryngeal tissue.
Topics: Animals; Head and Neck Neoplasms; Larynx; Malondialdehyde; Melatonin; Peroxidase; Radiation-Protecti | 2021 |
Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma.
Topics: Adult; Aged; Animals; Antioxidants; Apoptosis; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Tran | 2018 |
Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell L | 2018 |
The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antioxidants; Calcium; Carcinoma | 2012 |