Page last updated: 2024-10-19

melatonin and Cancer of Endometrium

melatonin has been researched along with Cancer of Endometrium in 17 studies

Research Excerpts

ExcerptRelevanceReference
"Laboratory study was via cultured endometrial cancer cells."5.72Melatonin Inhibits 17β-Estradiol-Induced Epithelial-Mesenchymal Transition in Endometrial Adenocarcinoma Cells via Upregulating Numb Expression. ( Li, C; Li, M; Liu, Z; Qi, S; Zhang, H; Zhao, X, 2022)
"Melatonin is a hormone synthesized in the pineal and extra-pineal organs such as the digestive tract, bone marrow, retina and more."2.66Molecular and Biological Functions of Melatonin in Endometrial Cancer. ( Asemi, Z; Chaichian, S; Chamani, M; Dana, PM; Moazzami, B; Mobini, M; Sadoughi, F; Shafabakhsh, R, 2020)
"Of particular relevance to breast cancer risk, melatonin may also block the estrogen receptor ERalpha and impact the enzyme aromatase, which produces estradiol."2.45Circulating melatonin and the risk of breast and endometrial cancer in women. ( Schernhammer, ES; Viswanathan, AN, 2009)
"Laboratory study was via cultured endometrial cancer cells."1.72Melatonin Inhibits 17β-Estradiol-Induced Epithelial-Mesenchymal Transition in Endometrial Adenocarcinoma Cells via Upregulating Numb Expression. ( Li, C; Li, M; Liu, Z; Qi, S; Zhang, H; Zhao, X, 2022)
"Treatment with melatonin restricted estrogen/UBC/SDHB-induced succinate accumulation and upregulated expression of KCNQ1 and reduced the succinate-mediated growth of UECC in vitro and in vivo."1.56Melatonin alleviates progression of uterine endometrial cancer by suppressing estrogen/ubiquitin C/SDHB-mediated succinate accumulation. ( Chang, K; Chang, R; Gu, C; Li, M; Qiu, X; Qu, Y; Wang, J; Wang, Y; Xie, F; Yang, H; Ye, J; Zhang, B, 2020)
"With low-grade endometrial carcinomas, the average index of EGF blood plasma level is higher compared to that of the patients with high-grade endometrial adenocarcinomas."1.40[Expression of epidermal growth factor receptor and concentrations of epidermal growth factor and melatonin in endometrial carcinoma]. ( Dznelashvili, N; Kasradze, D; Tavartkiladze, A, 2014)
"Using data from the Australian National Endometrial Cancer Study, a population-based case-control study of 1399 cases and 1539 controls, we examined the association between season of birth and risk of endometrial cancer."1.37Season of birth and risk of endometrial cancer. ( Nagle, CM; Rowlands, IJ; Spurdle, AB; Webb, PM; Weinstein, P, 2011)
"Melatonin has several oncostatic properties, including possible anti-estrogenic and anti-aromatase activity, and seems to be linked with fat metabolism."1.34Night shift work and the risk of endometrial cancer. ( Hankinson, SE; Schernhammer, ES; Viswanathan, AN, 2007)
"After surgical ablation of the breast tumors, serum's ability to increase MCF-7 cell proliferation decreased significantly."1.31Influence of serum from healthy or breast tumor-bearing women on the growth of MCF-7 human breast cancer cells. ( Alvarez, A; Bartsch, C; Bartsch, H; Cos, S; Mediavilla, MD; Sanchez-Barcelo, EJ, 2000)
"Pretreatment with luzindole, which is a selective melatonin receptor antagonist, prior to the addition of melatonin also blocked the inhibitory effect of melatonin on Ishikawa cells."1.31Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines. ( Ishizuka, B; Kanishi, Y; Kobayashi, Y; Noda, S; Saito, K, 2000)
"68 women were diagnosed with endometrial cancer, 70 patients had abnormal bleeding."1.30A significant correlation between melatonin deficiency and endometrial cancer. ( Grin, W; Grünberger, W, 1998)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (17.65)18.2507
2000's8 (47.06)29.6817
2010's3 (17.65)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Zhang, H1
Qi, S1
Liu, Z1
Li, C1
Li, M2
Zhao, X1
Dana, PM1
Sadoughi, F1
Mobini, M1
Shafabakhsh, R1
Chaichian, S1
Moazzami, B1
Chamani, M1
Asemi, Z1
Gu, C1
Yang, H1
Chang, K1
Zhang, B1
Xie, F1
Ye, J1
Chang, R1
Qiu, X1
Wang, Y1
Qu, Y1
Wang, J1
de Almeida Chuffa, LG1
Seiva, FRF1
Cucielo, MS1
Silveira, HS1
Reiter, RJ2
Lupi, LA1
Dznelashvili, N1
Kasradze, D1
Tavartkiladze, A1
Watanabe, M1
Kobayashi, Y3
Takahashi, N1
Kiguchi, K2
Ishizuka, B3
Viswanathan, AN2
Schernhammer, ES2
Rowlands, IJ1
Weinstein, P1
Nagle, CM1
Spurdle, AB1
Webb, PM1
Itoh, MT1
Kondo, H1
Okuma, Y1
Sato, S1
Kanishi, Y2
Hamada, N1
Hankinson, SE1
Erren, TC1
Pape, HG1
Piekarski, C1
Cohen, M1
Small, RA1
Brzezinski, A1
Grin, W1
Grünberger, W1
Chubb, CR1
Cos, S1
Alvarez, A1
Mediavilla, MD1
Bartsch, C2
Bartsch, H2
Sanchez-Barcelo, EJ1
Noda, S1
Saito, K1
Deerberg, F1
Mecke, D1

Reviews

3 reviews available for melatonin and Cancer of Endometrium

ArticleYear
Molecular and Biological Functions of Melatonin in Endometrial Cancer.
    Current drug targets, 2020, Volume: 21, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Endometrial Neoplasms; Female; Humans; Melatonin; Oxidati

2020
Mitochondrial functions and melatonin: a tour of the reproductive cancers.
    Cellular and molecular life sciences : CMLS, 2019, Volume: 76, Issue:5

    Topics: Animals; Breast Neoplasms; Endometrial Neoplasms; Female; Genital Neoplasms, Female; Humans; Male; M

2019
Circulating melatonin and the risk of breast and endometrial cancer in women.
    Cancer letters, 2009, Aug-18, Volume: 281, Issue:1

    Topics: Aromatase; Breast Neoplasms; Carcinoma; Case-Control Studies; Cell Transformation, Neoplastic; Circa

2009

Other Studies

14 other studies available for melatonin and Cancer of Endometrium

ArticleYear
Melatonin Inhibits 17β-Estradiol-Induced Epithelial-Mesenchymal Transition in Endometrial Adenocarcinoma Cells via Upregulating Numb Expression.
    Gynecologic and obstetric investigation, 2022, Volume: 87, Issue:2

    Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Epithelial-Mesenchymal

2022
Melatonin alleviates progression of uterine endometrial cancer by suppressing estrogen/ubiquitin C/SDHB-mediated succinate accumulation.
    Cancer letters, 2020, 04-28, Volume: 476

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Endometrial Neoplasms; Estrogens; Female;

2020
[Expression of epidermal growth factor receptor and concentrations of epidermal growth factor and melatonin in endometrial carcinoma].
    Georgian medical news, 2014, Issue:235

    Topics: Adult; Aged; Endometrial Neoplasms; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB

2014
Expression of melatonin receptor (MT1) and interaction between melatonin and estrogen in endometrial cancer cell line.
    The journal of obstetrics and gynaecology research, 2008, Volume: 34, Issue:4

    Topics: Cell Line, Tumor; Endometrial Neoplasms; Estrogens; Female; Humans; Melatonin; Receptor, Melatonin,

2008
Season of birth and risk of endometrial cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2011, Volume: 12, Issue:5

    Topics: Australia; Case-Control Studies; Endometrial Neoplasms; Female; Humans; Melatonin; Parturition; Risk

2011
Melatonin binding sites in estrogen receptor-positive cells derived from human endometrial cancer.
    Journal of pineal research, 2003, Volume: 35, Issue:2

    Topics: Binding Sites; Endometrial Neoplasms; Endometrium; Female; Humans; Melatonin; Receptors, Estrogen; R

2003
Night shift work and the risk of endometrial cancer.
    Cancer research, 2007, Nov-01, Volume: 67, Issue:21

    Topics: Adult; Body Mass Index; Cohort Studies; Endometrial Neoplasms; Female; Humans; Melatonin; Middle Age

2007
Not all shifts are equal: it's time for comprehensive exposure metrics in chronodisruption research.
    Cancer research, 2008, May-15, Volume: 68, Issue:10

    Topics: Data Interpretation, Statistical; Endometrial Neoplasms; Female; Humans; Male; Melatonin; Prospectiv

2008
Hypotheses: melatonin/steroid combination contraceptives will prevent breast cancer.
    Breast cancer research and treatment, 1995, Volume: 33, Issue:3

    Topics: Breast Neoplasms; Contraceptives, Oral, Combined; Endometrial Neoplasms; Female; Humans; Melatonin;

1995
A significant correlation between melatonin deficiency and endometrial cancer.
    Gynecologic and obstetric investigation, 1998, Volume: 45, Issue:1

    Topics: Aging; Austria; Biomarkers, Tumor; Cohort Studies; Endometrial Neoplasms; Female; Humans; Incidence;

1998
Re: a significant correlation between melatonin deficiency and endometrial cancer.
    Gynecologic and obstetric investigation, 1999, Volume: 48, Issue:2

    Topics: Endometrial Neoplasms; Female; Humans; Melatonin

1999
Influence of serum from healthy or breast tumor-bearing women on the growth of MCF-7 human breast cancer cells.
    International journal of molecular medicine, 2000, Volume: 5, Issue:6

    Topics: Adenocarcinoma, Papillary; Breast Neoplasms; Cell Division; Culture Media; Endometrial Neoplasms; Es

2000
Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines.
    Journal of pineal research, 2000, Volume: 28, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Agents; Cell Count; Cell Division; Endometrial Neoplasms; Estradiol;

2000
Seasonal rhythms of 6-sulphatoxymelatonin (aMT6s) excretion in female rats are abolished by growth of malignant tumors.
    Journal of pineal research, 2001, Volume: 31, Issue:1

    Topics: Animals; Endometrial Neoplasms; Female; Mammary Neoplasms, Experimental; Melatonin; Neoplasms, Exper

2001