Page last updated: 2024-10-19

melatonin and Cachexia

melatonin has been researched along with Cachexia in 11 studies

Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.

Research Excerpts

ExcerptRelevanceReference
"Prior studies have suggested that melatonin, a frequently used integrative medicine, can attenuate weight loss, anorexia, and fatigue in patients with cancer."9.17Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial. ( Bruera, E; Del Fabbro, E; Dev, R; Hui, D; Palmer, L, 2013)
"The effect of fish oil (FO), melatonin (MLT), or their combination and dietary advice on cachexia and biochemistry variables reflecting cachexia were investigated in patients with advanced gastrointestinal cancer."9.11Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study. ( Glimelius, B; Nygren, P; Persson, C; Rönnelid, J, 2005)
"Prior studies have suggested that melatonin, a frequently used integrative medicine, can attenuate weight loss, anorexia, and fatigue in patients with cancer."5.17Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial. ( Bruera, E; Del Fabbro, E; Dev, R; Hui, D; Palmer, L, 2013)
"The effect of fish oil (FO), melatonin (MLT), or their combination and dietary advice on cachexia and biochemistry variables reflecting cachexia were investigated in patients with advanced gastrointestinal cancer."5.11Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study. ( Glimelius, B; Nygren, P; Persson, C; Rönnelid, J, 2005)
"Cancer cachexia is a multi-organ syndrome with unintentional weight loss, sarcopenia, and systemic inflammation."3.01Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia. ( Grundmann, O; Yoon, SL, 2023)
"Studies have recruited heterogeneous cancer patient populations in late disease stages, and many had issues with accrual and attrition."2.61Anti-cytokines in the treatment of cancer cachexia. ( Prado, BL; Qian, Y, 2019)
"Patients with cancer frequently experience unintended weight loss due to gastrointestinal (GI) dysfunction caused by the malignancy or treatment of the malignancy."2.55Cancer Cachexia: Cause, Diagnosis, and Treatment. ( Mattox, TW, 2017)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's1 (9.09)29.6817
2010's6 (54.55)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Yoon, SL1
Grundmann, O1
Ballyuzek, MF1
Mashkova, MV1
Arutjunyan, AV1
Duke, VA1
Mattox, TW1
Prado, BL1
Qian, Y1
Jafari-Vayghan, H1
Saleh-Ghadimi, S1
Maleki, V1
Moludi, J1
Alizadeh, M1
Baracos, VE1
Del Fabbro, E1
Dev, R1
Hui, D1
Palmer, L1
Bruera, E2
Persson, C1
Glimelius, B1
Rönnelid, J1
Nygren, P1
Lissoni, P1
Paolorossi, F1
Tancini, G1
Barni, S1
Ardizzoia, A1
Brivio, F1
Zubelewicz, B1
Chatikhine, V1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessing Quality of Life and the Feasibility of a Nutrition and Pharmacological Algorithm for Oncology Patients With Anorexia[NCT04155008]Phase 41 participants (Actual)Interventional2021-03-01Terminated (stopped due to The trial was closed after 4 months due to slow to accrual. Only 1 participant was enrolled.)
The Traditional Chinese Medicine Department of Xin Qiao Hospital[NCT02619266]Phase 2/Phase 3160 participants (Anticipated)Interventional2015-12-31Recruiting
A Randomized Clinical Trial of Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients[NCT00513357]Phase 382 participants (Actual)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Appetite as Measured by ESAS

Difference in ESAS (Edmonton Symptom Assessment Scale) assessment scores of appetite (symptom) from baseline evaluation [± 3 days] to 4 week evaluation [± 3 days], where the severity at the time of assessment is rated from 0 to 10 on a numerical scale; with 0 meaning that the symptom is absent and 10 that it is the worst possible severity. (NCT00513357)
Timeframe: Baseline and at 4 weeks

Interventionunits on a scale (Mean)
Melatonin-0.83
Placebo-1.19

Reviews

5 reviews available for melatonin and Cachexia

ArticleYear
Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia.
    Nutrients, 2023, Jul-30, Volume: 15, Issue:15

    Topics: Cachexia; Dietary Supplements; Fatty Acids, Omega-3; Fish Oils; Gastrointestinal Neoplasms; Humans;

2023
Cancer Cachexia: Cause, Diagnosis, and Treatment.
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2017, Volume: 32, Issue:5

    Topics: Anabolic Agents; Animals; Anti-Inflammatory Agents; Appetite Stimulants; Cachexia; Combined Modality

2017
Anti-cytokines in the treatment of cancer cachexia.
    Annals of palliative medicine, 2019, Volume: 8, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cachexia; Cytokines; Etanercept; Forecast

2019
The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:10

    Topics: Cachexia; Forkhead Box Protein O1; Heart Diseases; Humans; Insulin-Like Growth Factor I; Melatonin;

2019
Pharmacological treatment of cachexia: any progress?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1998, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Antiemetics; Antioxidants; Appetite Stimulants; C

1998

Trials

3 trials available for melatonin and Cachexia

ArticleYear
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-01, Volume: 31, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl

2013
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-01, Volume: 31, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl

2013
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-01, Volume: 31, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl

2013
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-01, Volume: 31, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Appetite; Body Weight; Cachexia; Depression; Double-Bl

2013
Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study.
    Nutrition (Burbank, Los Angeles County, Calif.), 2005, Volume: 21, Issue:2

    Topics: Aged; Aged, 80 and over; Antioxidants; Body Weight; Cachexia; Cross-Over Studies; Cytokines; Dietary

2005
Is there a role for melatonin in the treatment of neoplastic cachexia?
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:8

    Topics: Adult; Aged; Cachexia; Female; Humans; Male; Melatonin; Middle Aged; Neoplasm Metastasis; Palliative

1996

Other Studies

3 other studies available for melatonin and Cachexia

ArticleYear
[Melatonin as a marker of the grade of cardiac disorders during cachexia development in oncological patients of different ages].
    Advances in gerontology = Uspekhi gerontologii, 2017, Volume: 30, Issue:1

    Topics: Adult; Age Factors; Aged; Biomarkers; Cachexia; False Positive Reactions; Heart Diseases; Humans; Me

2017
Clinical trials of cancer cachexia therapy, now and hereafter.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-01, Volume: 31, Issue:10

    Topics: Appetite; Cachexia; Female; Humans; Male; Melatonin; Neoplasms

2013
[The tumor-cahexy syndrome. Poor general health--a complex problem].
    Der Radiologe, 1998, Volume: 38, Issue:10 Suppl

    Topics: Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cachexia; Cisplatin; Etoposide; Gastrointe

1998