melatonin has been researched along with Brain Injuries in 88 studies
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "EA at GV20 and GV24 can reduce the neurolo-gical injury in cerebral ischemia reperfusion model rats, which may be related to regulating the expression of endogenous melatonin, inhibiting cell scorchification and reducing cerebral ischemia injury." | 8.31 | [Electroacupuncture alleviates cerebral ischemia injury in rats by regulating melatonin-NLRP3 and inhibiting pyroptosis]. ( Chen, B; Liang, H; Liu, JJ; Luo, J; Ruan, S; Wang, F; Wang, YX; Yan, NW; Zhong, XY, 2023) |
| "Following CI, it was observed that melatonin treatment improved the rotarod and adhesive removal test durations from day 5 and reduced the infarct area after CI." | 8.31 | Melatonin Attenuates Cerebral Ischemia/Reperfusion Injury through Inducing Autophagy. ( Gul, M; Gul, S; Koc, A; Sandal, S; Tanbek, K; Yilmaz, U, 2023) |
| "Melatonin is a potent neuroprotective agent which has shown therapeutic effects in animal models of brain injury such as stroke." | 8.12 | Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke. ( Cambiaghi, M; Cherchi, L; Comai, S, 2022) |
| "Melatonin pre-treatment lowered the level of proinflammatory cytokines in the uterus and the placenta, significantly improved LPS-induced acute fetal neuroinflammation and perinatal brain injury, as well as significantly upregulated the SIRT1/Nrf2 signaling pathway to reduce LPS-induced inflammation." | 7.91 | Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019) |
| "BACKGROUND A mouse model of subarachnoid hemorrhage (SAH) investigated the effects of melatonin treatment on the generation of reactive oxygen species (ROS) and the activation of the SIRT3 gene in early brain injury (EBI)." | 7.88 | Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ( Chen, X; Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "The objective of this study was to identify the protective effect of melatonin (MT) against early brain injury (EBI) following subarachnoid hemorrhage (SAH) and explore the underlying molecular mechanism." | 7.88 | Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor. ( He, Y; Li, S; Sun, B; Tang, W; Wen, L; Yang, S, 2018) |
| "BACKGROUND The aim of this study was to investigate whether melatonin is involved in brain injury following subarachnoid hemorrhage (SAH)." | 7.88 | Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage. ( Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "Melatonin (Mel) has been reported to alleviate early brain injury (EBI) following subarachnoid hemorrhage (SAH)." | 7.85 | Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice. ( Li, X; Lin, Y; Liu, H; Qu, Y; Wang, B; Yue, L; Zhang, J; Zhao, L, 2017) |
| "Melatonin is a strong antioxidant that has beneficial effects against early brain injury (EBI) following a subarachnoid hemorrhage (SAH) in rats; protection includes reduced mortality and brain water content." | 7.80 | Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage. ( Chen, G; Chen, J; Gu, C; Hu, Q; Li, J; Wang, L; Wu, C; Yan, F; Yan, W, 2014) |
| "Melatonin is a strong anti-oxidant that has beneficial effects against early brain injury (EBI) following a subarachnoid hemorrhage (SAH) in rats; protection includes the reduction of both mortality and neurological deficits." | 7.80 | Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines. ( Chen, G; Chen, J; Gu, C; Li, J; Mo, H; Qian, C; Wang, L; Yan, F; Yan, W, 2014) |
| "Melatonin decreases brain edema, BBB permeability and ICP, but increases VCS after TBI." | 7.79 | Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses. ( Asadikram, G; Dehghan, F; Khaksari Hadad, M; Najafipour, H; Shahrokhi, N, 2013) |
| "Previous studies proved that melatonin protected against secondary brain damage by modulating oxidative stress after experimental subarachnoid hemorrhage (SAH), but it has not been evaluated yet about its effects on inflammatory pathway and secondary cognitive dysfunction in SAH model." | 7.79 | Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway. ( Chen, G; Ji, C; Wang, Z; Wu, L; You, W, 2013) |
| "Melatonin has beneficial effects against early brain injury (EBI) by modulating cerebral oxidative stress after experimental subarachnoid hemorrhage (SAH); however, few investigations relate to the precise underlying molecular mechanisms." | 7.78 | Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. ( Chen, G; He, WC; Huo, L; Liu, HX; Ma, C; Meng, CJ; Shen, XM; Shu, Z; Sun, XB; Wang, Z; Zhang, J; Zhu, GQ, 2012) |
| "In this animal model, melatonin and mannitol had similar effects on brain edema, as demonstrated on MRI 3 and 36 hours after head trauma." | 7.74 | The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema. ( Ak, A; Bayir, A; Bodur, S; Cengiz, SL; Kara, H; Kireşi, DA; Koçak, S; Ozdinç, S, 2008) |
| "Although hypothermia is the standard of care for hypoxic-ischemic encephalopathy, it does not affect all changes associated with encephalopathy." | 7.01 | Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia. ( Furmaga-Jabłońska, W; Januszewski, S; Pluta, R; Tarkowska, A, 2023) |
| "Intrauterine inflammation is shown to be associated with preterm birth, fetal inflammatory response syndrome, and other pregnancy-related comorbidities such as central nervous system diseases including cerebral palsy and periventricular leukomalacia, pulmonary diseases such as bronchopulmonary dysplasia and respiratory distress syndrome, and necrotizing enterocolitis, to name a few." | 6.72 | Melatonin for the prevention of fetal injury associated with intrauterine inflammation. ( Kim, JM; Lee, JY; Lee, SY, 2021) |
| "Melatonin has been shown to be effective in arresting neurodegenerative phenomena seen in experimental models of Alzheimer's disease, Parkinsonism and ischemic stroke." | 6.43 | Role of melatonin in neurodegenerative diseases. ( Cardinali, DP; Esquifino, AI; Hardeland, R; Maestroni, GJ; Pandi-Perumal, SR; Srinivasan, V, 2005) |
| "In our study, we established a subarachnoid hemorrhage model in male SD rats." | 5.91 | Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage. ( Gao, C; Jiang, GY; Li, C; Li, JY; Liu, HL; Liu, N; Ma, SJ; Yan, C; Yan, HC; Yang, HR, 2023) |
| "Ischemic stroke is a leading cause of mortality and morbidity worldwide, with neuroinflammation playing a key role in its pathophysiology." | 5.91 | Melatonin regulates microglial polarization and protects against ischemic stroke-induced brain injury in mice. ( He, T; Li, D; Liu, J; Wang, D; Wang, Q; Yuan, Y; Zhang, S; Zhang, Y; Zhao, H, 2023) |
| "Melatonin (15 mg/kg) was administered 5 min after HI." | 5.91 | MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Dell'Orto, V; Perrone, S; Vanzolini, T; Weiss, MD, 2023) |
| " Because children with CP from preterm birth also exhibit a sustained immune system hyper-reactivity, we hypothesized that neuro-immunomodulation with a regimen of repurposed endogenous neurorestorative medications, erythropoietin (EPO) and melatonin (MLT), could improve this trajectory." | 5.51 | Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury. ( Burkhardt, C; Burton, VJ; Fouda, MA; Gerner, G; Hamimi, S; Jantzie, LL; Kitase, Y; Muthukumar, S; Northington, FJ; Robinson, S; Scafidi, J; Vasan, V; Ye, X, 2022) |
| "Sepsis is a systemic inflammatory response to infection that causes severe neurological complications." | 5.42 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. ( An, R; Li, X; Lin, Y; Liu, H; Qu, Y; Reiter, RJ; Yang, X; Yang, Y; Yue, L; Zhao, L, 2015) |
| "Aneurysmal subarachnoid hemorrhage (SAH) is a devastating disease that is associated with significant morbidity and mortality." | 5.35 | Effects of melatonin in early brain injury following subarachnoid hemorrhage. ( Ayer, RE; Sugawara, T; Zhang, JH, 2008) |
| "EA at GV20 and GV24 can reduce the neurolo-gical injury in cerebral ischemia reperfusion model rats, which may be related to regulating the expression of endogenous melatonin, inhibiting cell scorchification and reducing cerebral ischemia injury." | 4.31 | [Electroacupuncture alleviates cerebral ischemia injury in rats by regulating melatonin-NLRP3 and inhibiting pyroptosis]. ( Chen, B; Liang, H; Liu, JJ; Luo, J; Ruan, S; Wang, F; Wang, YX; Yan, NW; Zhong, XY, 2023) |
| "Following CI, it was observed that melatonin treatment improved the rotarod and adhesive removal test durations from day 5 and reduced the infarct area after CI." | 4.31 | Melatonin Attenuates Cerebral Ischemia/Reperfusion Injury through Inducing Autophagy. ( Gul, M; Gul, S; Koc, A; Sandal, S; Tanbek, K; Yilmaz, U, 2023) |
| "Melatonin is a potent neuroprotective agent which has shown therapeutic effects in animal models of brain injury such as stroke." | 4.12 | Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke. ( Cambiaghi, M; Cherchi, L; Comai, S, 2022) |
| "Melatonin pre-treatment lowered the level of proinflammatory cytokines in the uterus and the placenta, significantly improved LPS-induced acute fetal neuroinflammation and perinatal brain injury, as well as significantly upregulated the SIRT1/Nrf2 signaling pathway to reduce LPS-induced inflammation." | 3.91 | Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019) |
| "The objective of this study was to identify the protective effect of melatonin (MT) against early brain injury (EBI) following subarachnoid hemorrhage (SAH) and explore the underlying molecular mechanism." | 3.88 | Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor. ( He, Y; Li, S; Sun, B; Tang, W; Wen, L; Yang, S, 2018) |
| "BACKGROUND A mouse model of subarachnoid hemorrhage (SAH) investigated the effects of melatonin treatment on the generation of reactive oxygen species (ROS) and the activation of the SIRT3 gene in early brain injury (EBI)." | 3.88 | Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ( Chen, X; Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "BACKGROUND The aim of this study was to investigate whether melatonin is involved in brain injury following subarachnoid hemorrhage (SAH)." | 3.88 | Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage. ( Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "Melatonin (Mel) has been reported to alleviate early brain injury (EBI) following subarachnoid hemorrhage (SAH)." | 3.85 | Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice. ( Li, X; Lin, Y; Liu, H; Qu, Y; Wang, B; Yue, L; Zhang, J; Zhao, L, 2017) |
| "Melatonin is a strong anti-oxidant that has beneficial effects against early brain injury (EBI) following a subarachnoid hemorrhage (SAH) in rats; protection includes the reduction of both mortality and neurological deficits." | 3.80 | Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines. ( Chen, G; Chen, J; Gu, C; Li, J; Mo, H; Qian, C; Wang, L; Yan, F; Yan, W, 2014) |
| "Melatonin is a strong antioxidant that has beneficial effects against early brain injury (EBI) following a subarachnoid hemorrhage (SAH) in rats; protection includes reduced mortality and brain water content." | 3.80 | Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage. ( Chen, G; Chen, J; Gu, C; Hu, Q; Li, J; Wang, L; Wu, C; Yan, F; Yan, W, 2014) |
| "Melatonin decreases brain edema, BBB permeability and ICP, but increases VCS after TBI." | 3.79 | Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses. ( Asadikram, G; Dehghan, F; Khaksari Hadad, M; Najafipour, H; Shahrokhi, N, 2013) |
| "Previous studies proved that melatonin protected against secondary brain damage by modulating oxidative stress after experimental subarachnoid hemorrhage (SAH), but it has not been evaluated yet about its effects on inflammatory pathway and secondary cognitive dysfunction in SAH model." | 3.79 | Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway. ( Chen, G; Ji, C; Wang, Z; Wu, L; You, W, 2013) |
| "Melatonin has beneficial effects against early brain injury (EBI) by modulating cerebral oxidative stress after experimental subarachnoid hemorrhage (SAH); however, few investigations relate to the precise underlying molecular mechanisms." | 3.78 | Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. ( Chen, G; He, WC; Huo, L; Liu, HX; Ma, C; Meng, CJ; Shen, XM; Shu, Z; Sun, XB; Wang, Z; Zhang, J; Zhu, GQ, 2012) |
| "6 days post injury) and 23 age- and gender-matched healthy volunteers on polysomnographic sleep measures, salivary dim light melatonin onset (DLMO) time, and self-reported sleep quality, anxiety, and depression." | 3.76 | Sleep disturbance and melatonin levels following traumatic brain injury. ( Parcell, DL; Phipps-Nelson, J; Ponsford, JL; Rajaratnam, SM; Redman, JR; Shekleton, JA, 2010) |
| "The results showed a trend in decreasing brain edema with lower doses of melatonin (5 mg/kg and 15 mg/ kg), however, high concentration of melatonin (150 mg/kg) significantly increased brain edema compared to all other groups." | 3.74 | The antioxidant effects of melatonin in surgical brain injury in rats. ( Ayer, R; Hyong, A; Jadhav, V; Lee, S; Lekic, T; Martin, R; Rojas, H; Stier, G; Zhang, JH, 2008) |
| "In this animal model, melatonin and mannitol had similar effects on brain edema, as demonstrated on MRI 3 and 36 hours after head trauma." | 3.74 | The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema. ( Ak, A; Bayir, A; Bodur, S; Cengiz, SL; Kara, H; Kireşi, DA; Koçak, S; Ozdinç, S, 2008) |
| "In 66 patients with some diseases of the nervous system (epilepsy, brain tumors, traumatic brain lesions, discorgenic lumbosacral radiculitis) melatonin content in liquor was determined by a fluorimetric method, especially modified for this purpose." | 3.65 | [Cerebrospinal fluid melatonin in diseases of the nervous system]. ( Kiselev, VN; Loboda, EB; Makarov, AIu, 1977) |
| "Although hypothermia is the standard of care for hypoxic-ischemic encephalopathy, it does not affect all changes associated with encephalopathy." | 3.01 | Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia. ( Furmaga-Jabłońska, W; Januszewski, S; Pluta, R; Tarkowska, A, 2023) |
| "Melatonin has a protective effect not only on the brain, by attenuating its injury, but on extracranial organs, including the heart." | 2.82 | Melatonin and the Brain-Heart Crosstalk in Neurocritically Ill Patients-From Molecular Action to Clinical Practice. ( Bekała, A; Bielacz, M; Biernawska, J; Bohatyrewicz, R; Dabrowski, W; Jaroszyński, A; Kotfis, K; Płotek, W; Siwicka-Gieroba, D; Sołek-Pastuszka, J, 2022) |
| "Intrauterine inflammation is shown to be associated with preterm birth, fetal inflammatory response syndrome, and other pregnancy-related comorbidities such as central nervous system diseases including cerebral palsy and periventricular leukomalacia, pulmonary diseases such as bronchopulmonary dysplasia and respiratory distress syndrome, and necrotizing enterocolitis, to name a few." | 2.72 | Melatonin for the prevention of fetal injury associated with intrauterine inflammation. ( Kim, JM; Lee, JY; Lee, SY, 2021) |
| "Osteoporosis is the most common bone disease in humans." | 2.61 | The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. ( Aly, H; Bhattacharya, P; Chiocca, EA; Cui, Y; Fu, J; Jiang, J; Johnson, MD; Lawler, SE; Liu, Y; Luo, C; Ma, H; Reiter, RJ; Rozental, R; Wang, X; Yang, H; Yang, Q; Yao, J; Zhang, X; Zhou, S, 2019) |
| "Melatonin has been shown to be a versatile hormone having antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties." | 2.50 | Role of melatonin in traumatic brain injury and spinal cord injury. ( Naseem, M; Parvez, S, 2014) |
| "Furthermore, insomnia is often associated with psychiatric comorbidities, and some patients with posttraumatic disruption of their circadian rhythm may be misdiagnosed as insomnia patients." | 2.48 | Traumatic brain injury and disturbed sleep and wakefulness. ( Baumann, CR, 2012) |
| "The literature describes sleep disorders as common in both conditions." | 2.48 | Interventions with a sleep outcome for children with cerebral palsy or a post-traumatic brain injury: a systematic review. ( Elder, DE; Galland, BC; Taylor, BJ, 2012) |
| "Melatonin has been shown to be effective in arresting neurodegenerative phenomena seen in experimental models of Alzheimer's disease, Parkinsonism and ischemic stroke." | 2.43 | Role of melatonin in neurodegenerative diseases. ( Cardinali, DP; Esquifino, AI; Hardeland, R; Maestroni, GJ; Pandi-Perumal, SR; Srinivasan, V, 2005) |
| "In our study, we established a subarachnoid hemorrhage model in male SD rats." | 1.91 | Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage. ( Gao, C; Jiang, GY; Li, C; Li, JY; Liu, HL; Liu, N; Ma, SJ; Yan, C; Yan, HC; Yang, HR, 2023) |
| "Melatonin (15 mg/kg) was administered 5 min after HI." | 1.91 | MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Dell'Orto, V; Perrone, S; Vanzolini, T; Weiss, MD, 2023) |
| "Melatonin has possibilities used as a daily nutraceutical to trigger the cellular adaptation." | 1.91 | Prophylactic supplement with melatonin prevented the brain injury after cardiac arrest in rats. ( Han, F; Hu, Y; Jiang, G; Jiang, W; Jin, M; Zhao, X, 2023) |
| "Ischemic stroke is a leading cause of mortality and morbidity worldwide, with neuroinflammation playing a key role in its pathophysiology." | 1.91 | Melatonin regulates microglial polarization and protects against ischemic stroke-induced brain injury in mice. ( He, T; Li, D; Liu, J; Wang, D; Wang, Q; Yuan, Y; Zhang, S; Zhang, Y; Zhao, H, 2023) |
| "Melatonin treatment has benefitted neonates with hypoxic-ischemic (HI) brain injury." | 1.72 | Human-rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic-ischemic pathway melatonin-sensitive. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Coppari, S; Longini, M; Melandri, D; Mohammadi, A; Negrini, M; Perrone, S; Rocchi, MBL; Sura, L; Vanzolini, T; Weiss, MD, 2022) |
| "A melatonin rhythm was present in both groups, and no group differences were found on melatonin variables." | 1.56 | Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm. ( Bernard, F; Blais, H; Duclos, C; Dumont, M; Gosselin, N; Menon, DK; Paquet, J; Van der Maren, S, 2020) |
| "Preterm birth is a major contributor to early and delayed physical and cognitive impairment." | 1.46 | Maternal administration of melatonin exerts short- and long-term neuroprotective effects on the offspring from lipopolysaccharide-treated mice. ( Aisemberg, J; Bariani, MV; Correa, F; Domínguez Rubio, AP; Dorfman, D; Franchi, AM; Rosenstein, RE; Zorrilla Zubilete, M, 2017) |
| "Melatonin was injected intraperitoneally 1 h before lipopolysaccharide injection and then once a day for 1 week to evaluate the long-term effects." | 1.46 | Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats. ( Fang, M; Gao, Z; Hu, Y; Jiang, H; Li, Z; Lin, Z; Pan, S; Wang, Z; Xiao, J; Xu, K; Zhang, H, 2017) |
| "Melatonin treatment did not show a protective effect on neuronal metabolism." | 1.43 | No improvement of neuronal metabolism in the reperfusion phase with melatonin treatment after hypoxic-ischemic brain injury in the neonatal rat. ( Berger, HR; Brubakk, AM; Morken, TS; Sonnewald, U; Vettukattil, R; Widerøe, M, 2016) |
| "Melatonin, which is a very effective reactive oxygen species (ROS) scavenger, acts through a direct reaction with free radicals." | 1.42 | Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: Possible involvement of TRPM2 channels. ( Nazıroğlu, M; Şenol, N; Yürüker, V, 2015) |
| "Melatonin has been proven to possess neuroprotection property against various neurological diseases by decreasing cerebral oxidative stress and inhibiting inflammatory process." | 1.42 | Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice. ( Ding, K; Li, T; Wang, H; Wu, Y; Xu, J; Zhang, L, 2015) |
| "Sepsis is a systemic inflammatory response to infection that causes severe neurological complications." | 1.42 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. ( An, R; Li, X; Lin, Y; Liu, H; Qu, Y; Reiter, RJ; Yang, X; Yang, Y; Yue, L; Zhao, L, 2015) |
| "Melatonin treatment significantly reduced LPS-induced neurobehavioral disturbances and brain damage in neonatal rats." | 1.40 | Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats. ( Fan, LW; Jow, GM; Kaizaki, A; Tien, LT; Wong, CS, 2014) |
| "Melatonin (10mg/kg) was administered via an intraperitoneal (ip) injection at 0, 1, 2, 3, and 4h post-TBI." | 1.40 | Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism. ( Ding, K; Ding, Y; He, J; Li, T; Wang, H; Xu, J; Zhang, L; Zhou, M; Zhu, L, 2014) |
| " These results suggest that neither drug has therapeutic efficacy, however dosing and/or administration issues may have played a role." | 1.37 | Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury. ( Kelso, ML; Pauly, JR; Scheff, NN; Scheff, SW, 2011) |
| "Aneurysmal subarachnoid hemorrhage (SAH) is a devastating disease that is associated with significant morbidity and mortality." | 1.35 | Effects of melatonin in early brain injury following subarachnoid hemorrhage. ( Ayer, RE; Sugawara, T; Zhang, JH, 2008) |
| "Melatonin was injected intraperitoneally at the doses of 5 or 20 mg/kg of body weight immediately after induction of traumatic injury." | 1.33 | Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats. ( Acikgoz, O; Duman, M; Ozdemir, D; Ozdemir, N; Ozkan, H; Sonmez, A; Sonmez, U; Tugyan, K; Uysal, N, 2005) |
| "Melatonin (50 mg/kg) was administered, intraperitoneally, immediately after trauma." | 1.33 | The effects of environmental light--dark changes on experimental mild traumatic brain injury. ( Akyuz, M; Demir, N; Gurer, I; Onal, MZ; Ozkaya, G; Ucar, T, 2005) |
| "Melatonin (100 mg/kg) was given intraperitoneally immediately after trauma to the rats in Groups 3 and 6." | 1.33 | Effect of pinealectomy and melatonin replacement on morphological and biochemical recovery after traumatic brain injury. ( Altinoz, E; Ates, O; Cayli, S; Gurses, I; Iraz, M; Kocak, A; Yologlu, S; Yucel, N, 2006) |
| "Melatonin treatment reversed the ischemia/reperfusion-induced reductions in the RCI (2." | 1.31 | Melatonin protects against ischemia/reperfusion-induced oxidative damage to mitochondria in fetal rat brain. ( Fukaya, T; Ikenoue, N; Okatani, Y; Shinohara, K; Wakatsuki, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.14) | 18.7374 |
| 1990's | 3 (3.41) | 18.2507 |
| 2000's | 19 (21.59) | 29.6817 |
| 2010's | 45 (51.14) | 24.3611 |
| 2020's | 20 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| Lorente, L | 1 |
| Martín, MM | 1 |
| Ruiz, C | 1 |
| Abreu-González, P | 1 |
| Ramos-Gómez, L | 1 |
| Argueso, M | 1 |
| Sole-Violan, J | 1 |
| Cáceres, JJ | 1 |
| Jiménez, A | 1 |
| Jantzie, LL | 1 |
| Muthukumar, S | 1 |
| Kitase, Y | 1 |
| Vasan, V | 1 |
| Fouda, MA | 1 |
| Hamimi, S | 1 |
| Burkhardt, C | 1 |
| Burton, VJ | 1 |
| Gerner, G | 1 |
| Scafidi, J | 1 |
| Ye, X | 1 |
| Northington, FJ | 1 |
| Robinson, S | 1 |
| Bekała, A | 1 |
| Płotek, W | 1 |
| Siwicka-Gieroba, D | 1 |
| Sołek-Pastuszka, J | 1 |
| Bohatyrewicz, R | 1 |
| Biernawska, J | 1 |
| Kotfis, K | 1 |
| Bielacz, M | 1 |
| Jaroszyński, A | 1 |
| Dabrowski, W | 1 |
| Weiss, MD | 2 |
| Carloni, S | 2 |
| Vanzolini, T | 2 |
| Coppari, S | 1 |
| Balduini, W | 2 |
| Buonocore, G | 2 |
| Longini, M | 1 |
| Perrone, S | 2 |
| Sura, L | 1 |
| Mohammadi, A | 1 |
| Rocchi, MBL | 1 |
| Negrini, M | 1 |
| Melandri, D | 1 |
| Albertini, MC | 2 |
| Cambiaghi, M | 1 |
| Cherchi, L | 1 |
| Comai, S | 1 |
| Pluta, R | 1 |
| Furmaga-Jabłońska, W | 1 |
| Januszewski, S | 1 |
| Tarkowska, A | 1 |
| Yan, NW | 1 |
| Ruan, S | 1 |
| Wang, F | 1 |
| Wang, YX | 1 |
| Chen, B | 1 |
| Luo, J | 1 |
| Liu, JJ | 1 |
| Liang, H | 1 |
| Zhong, XY | 1 |
| de Oliveira Moura Araújo, E | 1 |
| Gavioli, EC | 1 |
| Holanda, VAD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Circadian Disturbances in People With Mental Disease[NCT05413486] | 86 participants (Anticipated) | Observational | 2022-04-04 | Recruiting | |||
| PLAY GAME: Post-concussion Syndrome Affecting Youth: GABAergic Effects of Melatonin. A Randomized Double-blind Placebo-controlled Trial of MELATONIN[NCT01874847] | Phase 2/Phase 3 | 99 participants (Actual) | Interventional | 2013-09-30 | Active, not recruiting | ||
| Assessment of the Efficacy of Medrol Dose Pack for Post-Concussive Headaches[NCT04685772] | 25 participants (Anticipated) | Observational [Patient Registry] | 2021-04-01 | Recruiting | |||
| Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury[NCT02732288] | 1 participants (Actual) | Interventional | 2016-05-31 | Terminated (stopped due to Interrupted by Covid-19) | |||
| Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial.[NCT03368430] | Phase 4 | 74 participants (Actual) | Interventional | 2016-07-04 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for melatonin and Brain Injuries
| Article | Year |
|---|---|
Melatonin and the Brain-Heart Crosstalk in Neurocritically Ill Patients-From Molecular Action to Clinical Practice.
Topics: Antioxidants; Brain; Brain Injuries; Brain Injuries, Traumatic; Heart Diseases; Humans; Melatonin | 2022 |
Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia.
Topics: Animals; Asphyxia; Asphyxia Neonatorum; Brain Injuries; Female; Humans; Hypothermia; Hypoxia-Ischemi | 2023 |
Free radicals and neonatal encephalopathy: mechanisms of injury, biomarkers, and antioxidant treatment perspectives.
Topics: Acetylcysteine; Allopurinol; Animals; Antioxidants; Asphyxia Neonatorum; Biomarkers; Brain Injuries; | 2020 |
Melatonin for the prevention of fetal injury associated with intrauterine inflammation.
Topics: Animals; Anti-Inflammatory Agents; Brain Injuries; Bronchopulmonary Dysplasia; Female; Fetal Disease | 2021 |
The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health.
Topics: Animals; Brain Injuries; Humans; Liver Diseases; Melatonin; Neuroprotective Agents; Osteoporosis; Ox | 2019 |
Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: evidence from a systematic review.
Topics: Adolescent; Brain Injuries; Central Nervous System Depressants; Child; Child, Preschool; Humans; Mel | 2014 |
Sleep and wake disturbances following traumatic brain injury.
Topics: Blast Injuries; Brain Damage, Chronic; Brain Injuries; Chronobiology Disorders; Cognitive Behavioral | 2014 |
Role of melatonin in traumatic brain injury and spinal cord injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Humans; Melatonin; Neuroprotective Agents; Oxidativ | 2014 |
Sleep disruption and the sequelae associated with traumatic brain injury.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain Injuries; Cogniti | 2015 |
Ventilation-Induced Brain Injury in Preterm Neonates: A Review of Potential Therapies.
Topics: Brain Injuries; Delivery Rooms; Erythropoietin; Female; Glucocorticoids; Humans; Infant, Newborn; In | 2016 |
Traumatic brain injury and disturbed sleep and wakefulness.
Topics: Animals; Brain Injuries; Humans; Intracellular Signaling Peptides and Proteins; Melatonin; Neuropept | 2012 |
Interventions with a sleep outcome for children with cerebral palsy or a post-traumatic brain injury: a systematic review.
Topics: Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Humans; Hypnotics and Sedatives; Infant; Me | 2012 |
Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.
Topics: Aging; Animals; Antioxidants; Apoptosis; Brain Injuries; Circadian Rhythm; Clinical Trials as Topic; | 2013 |
Role of melatonin in neurodegenerative diseases.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Brain Chemistry; Brain Injuries; Free Radical Scave | 2005 |
2 trials available for melatonin and Brain Injuries
| Article | Year |
|---|---|
Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury.
Topics: Animals; Brain Injuries; Erythropoietin; Female; Gait; Humans; Infant; Melatonin; Pregnancy; Prematu | 2022 |
[Treatment of sleep disorders in patients with mild cranial-brain injury in the early rehabilitation period].
Topics: Adult; Brain Injuries; Female; Humans; Male; Melatonin; Middle Aged; Sleep Wake Disorders; Treatment | 2014 |
72 other studies available for melatonin and Brain Injuries
| Article | Year |
|---|---|
Serum melatonin levels in predicting mortality in patients with severe traumatic brain injury.
Topics: Brain Injuries; Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Melatonin; Neuroinflammatory | 2021 |
Human-rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic-ischemic pathway melatonin-sensitive.
Topics: Animals; Animals, Newborn; Brain Injuries; Humans; Hypothermia; Hypoxia-Ischemia, Brain; Melatonin; | 2022 |
Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke.
Topics: Animals; Brain Injuries; Brain Ischemia; Disease Models, Animal; Humans; Ischemic Stroke; Melatonin; | 2022 |
[Electroacupuncture alleviates cerebral ischemia injury in rats by regulating melatonin-NLRP3 and inhibiting pyroptosis].
Topics: Animals; Brain Injuries; Brain Ischemia; Caspase 1; Cerebral Infarction; Electroacupuncture; Melaton | 2023 |
Repeated donkey milk consumption reduces anxiety-like behaviors and brain oxidative damage to lipids in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Brain Injuries; Depression; Lipids; | 2023 |
Melatonin regulates microglial polarization and protects against ischemic stroke-induced brain injury in mice.
Topics: Animals; Brain Injuries; Brain Ischemia; Infarction, Middle Cerebral Artery; Ischemic Stroke; Melato | 2023 |
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemas | 2023 |
Melatonin Attenuates Cerebral Ischemia/Reperfusion Injury through Inducing Autophagy.
Topics: Animals; Autophagy; Beclin-1; Brain Injuries; Brain Ischemia; Caspase 3; Infarction; Infarction, Mid | 2023 |
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage.
Topics: Animals; Brain Injuries; Ferroptosis; Iron; Male; Melatonin; NF-E2-Related Factor 2; Rats; Rats, Spr | 2023 |
MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia.
Topics: Animals; Animals, Newborn; Biomarkers; Brain; Brain Injuries; Female; Hypoxia-Ischemia, Brain; Ische | 2023 |
Prophylactic supplement with melatonin prevented the brain injury after cardiac arrest in rats.
Topics: Animals; Brain Injuries; Dietary Supplements; Heart Arrest; Humans; Melatonin; Rats; Rats, Sprague-D | 2023 |
Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm.
Topics: Actigraphy; Adult; Brain Injuries; Brain Injuries, Traumatic; Circadian Clocks; Circadian Rhythm; Fe | 2020 |
The protective effect of melatonin on benzo(a)pyrene-induced brain injury: role of apoptosis and autophagy pathways.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Benzo(a)pyrene; Brain Injuries; Dose-Response Relations | 2020 |
Melatonin ameliorates diabetes-induced brain injury in rats.
Topics: Animals; Blood Glucose; Brain Injuries; Diabetes Mellitus; Immunohistochemistry; Male; Melatonin; Ox | 2021 |
Melatonin exerts a neuroprotective effect against γ-radiation-induced brain injury in the rat through the modulation of neurotransmitters, inflammatory cytokines, oxidative stress, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Brain Injuries; Cytokines; Male; Melatonin; Neuroprotective Agents | 2021 |
Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats.
Topics: Adherens Junctions; Animals; Animals, Newborn; Blood-Brain Barrier; Brain Injuries; Disease Models, | 2017 |
Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury.
Topics: Animals; Annexin A5; Antioxidants; Apoptosis; Benzimidazoles; Brain Edema; Brain Injuries; Carbocyan | 2018 |
Maternal administration of melatonin exerts short- and long-term neuroprotective effects on the offspring from lipopolysaccharide-treated mice.
Topics: Animals; Birth Injuries; Brain Injuries; Female; Inflammation; Lipopolysaccharides; Melatonin; Mice; | 2017 |
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Topics: Animals; Brain Injuries; Brain Ischemia; Cytochromes c; Male; Melatonin; Mice; Mitochondria; Recepto | 2017 |
Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Cell Line, Tumor; Humans; Male; Melatonin; Mice, Inbred C | 2018 |
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
Topics: Animals; Apoptosis; Brain Edema; Brain Injuries; Cell Line, Tumor; Disease Models, Animal; Humans; M | 2018 |
Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage.
Topics: Animals; Apoptosis; Autophagy; Brain Edema; Brain Injuries; Male; Melatonin; Mice; Mice, Inbred C57B | 2018 |
Clinical significance of detecting serum melatonin and SBDPs in brain injury in preterm infants.
Topics: Brain; Brain Injuries; Case-Control Studies; Cerebral Infarction; Cerebral Intraventricular Hemorrha | 2019 |
Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model.
Topics: Animals; Brain Injuries; Disease Models, Animal; Female; Fetal Diseases; Hemodynamics; Humans; Immun | 2019 |
Regulation of Circadian Clock Genes on Sleep Disorders in Traumatic Brain Injury Patients.
Topics: Adolescent; Adult; ARNTL Transcription Factors; Brain Injuries; Circadian Clocks; CLOCK Proteins; Fe | 2019 |
Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage.
Topics: Animals; Apoptosis; Brain Injuries; Cerebral Hemorrhage; Deubiquitinating Enzymes; Disease Models, A | 2019 |
Combination therapy with melatonin and dexamethasone in a mouse model of traumatic brain injury.
Topics: Animals; Brain; Brain Injuries; Dexamethasone; Drug Therapy, Combination; Glucocorticoids; Male; Mel | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Intracranial Pressure; Male; Malon | 2013 |
Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway.
Topics: Animals; Blotting, Western; Brain Injuries; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immu | 2013 |
Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage.
Topics: Analysis of Variance; Animals; Apoptosis; Autophagy; bcl-2-Associated X Protein; Brain Injuries; Cyt | 2014 |
Challenging behaviour and sleep cycle disorder following brain injury: a preliminary response to agomelatine treatment.
Topics: Acetamides; Brain Injuries; Cognition Disorders; Humans; Hypnotics and Sedatives; Male; Melatonin; M | 2014 |
Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats.
Topics: Aldehydes; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Antioxidants; Brain Injuries; | 2014 |
Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism.
Topics: Active Transport, Cell Nucleus; Animals; Antioxidant Response Elements; Brain Edema; Brain Injuries; | 2014 |
Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Injuries; Enzyme-Linked Immunosorbent Assay; Flu | 2014 |
Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines.
Topics: Animals; Brain Edema; Brain Injuries; Cytokines; Inflammation Mediators; Male; Melatonin; Rats; Rats | 2014 |
Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: Possible involvement of TRPM2 channels.
Topics: Animals; Apoptosis; Benzene Derivatives; Biological Transport; Boron Compounds; Brain Injuries; Calc | 2015 |
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Topics: Animals; Apoptosis; Brain Injuries; Cytokines; Gene Expression Regulation; Inflammation; Male; Melat | 2015 |
The neuroprotective and anti-apoptotic effects of melatonin on hemolytic hyperbilirubinemia-induced oxidative brain damage.
Topics: Animals; Apoptosis; Brain Injuries; Cytokines; Disease Models, Animal; Jaundice; Melatonin; Nerve Ti | 2016 |
No improvement of neuronal metabolism in the reperfusion phase with melatonin treatment after hypoxic-ischemic brain injury in the neonatal rat.
Topics: Acetates; Animals; Animals, Newborn; Antioxidants; Astrocytes; Brain Injuries; Brain Ischemia; Disea | 2016 |
Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice.
Topics: Adenine; Animals; Apoptosis; Autophagy; bcl-2-Associated X Protein; Body Water; Brain Chemistry; Bra | 2015 |
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine.
Topics: Animals; Brain; Brain Infarction; Brain Injuries; DNA Fragmentation; Free Radical Scavengers; Male; | 2016 |
Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice.
Topics: Animals; Antioxidants; Brain Injuries; Male; Melatonin; Mice; Mice, Inbred C57BL; NF-kappa B; Random | 2017 |
Dual effects of melatonin on oxidative stress after surgical brain injury in rats.
Topics: Analysis of Variance; Animals; Brain; Brain Edema; Brain Injuries; Dose-Response Relationship, Drug; | 2009 |
Melatonin attenuates the cerebral ischemic injury via the MEK/ERK/p90RSK/bad signaling cascade.
Topics: Animals; bcl-Associated Death Protein; Brain Injuries; Brain Ischemia; Cell Death; Cerebral Infarcti | 2008 |
The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Female; Intracranial Pressure; | 2008 |
Effects of melatonin in early brain injury following subarachnoid hemorrhage.
Topics: Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Male | 2008 |
The antioxidant effects of melatonin in surgical brain injury in rats.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Re | 2008 |
An unusual cause of insomnia following IED-induced traumatic brain injury.
Topics: Adult; Bombs; Brain Injuries; Central Nervous System Depressants; Depressive Disorder; Eye Injuries; | 2010 |
Sleep disturbance and melatonin levels following traumatic brain injury.
Topics: Adult; Anxiety; Area Under Curve; Brain Injuries; Case-Control Studies; Depression; Electroencephalo | 2010 |
Posttreatment with uridine and melatonin following traumatic brain injury reduces edema in various brain regions in rats.
Topics: Animals; Brain Edema; Brain Injuries; Male; Melatonin; Rats; Rats, Sprague-Dawley; Uridine | 2010 |
Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Avoidance Learning; Brain Injuries; Cerebral Cortex; D | 2011 |
Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats.
Topics: Animals; Antioxidants; Brain Injuries; Interleukin-6; Male; Melatonin; Nerve Tissue Proteins; Nitric | 2011 |
Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model.
Topics: Animals; Blotting, Western; Brain Injuries; Disease Models, Animal; Immunohistochemistry; In Situ Ni | 2012 |
The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Drug Combinations; Lipid Peroxi | 2012 |
Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Free Radical Scavengers; G | 2005 |
Does melatonin protect or treat brain damage from traumatic oxidative stress?
Topics: Animals; Antioxidants; Brain; Brain Injuries; Catalase; Free Radical Scavengers; Glutathione Peroxid | 2005 |
The effect of traumatic brain injury on the timing of sleep.
Topics: Adult; Biological Clocks; Brain Injuries; Chronobiology Phenomena; Circadian Rhythm; Female; Humans; | 2005 |
Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats.
Topics: Animals; Apoptosis; Brain Injuries; Hippocampus; In Situ Nick-End Labeling; Maze Learning; Melatonin | 2005 |
The effects of environmental light--dark changes on experimental mild traumatic brain injury.
Topics: Animals; Brain Injuries; Circadian Rhythm; Darkness; Electroencephalography; Lighting; Male; Melaton | 2005 |
Prophylactic role of melatonin against radiation induced damage in mouse cerebellum with special reference to Purkinje cells.
Topics: Animals; Brain Injuries; Cell Survival; Cells, Cultured; Cerebellum; Male; Melatonin; Mice; Purkinje | 2006 |
Effect of pinealectomy and melatonin replacement on morphological and biochemical recovery after traumatic brain injury.
Topics: Animals; Brain Injuries; Free Radical Scavengers; Glutathione; Male; Malondialdehyde; Melatonin; Neu | 2006 |
Melatonin secretion after head injury: a pilot study.
Topics: Adult; Body Temperature; Brain Injuries; Circadian Rhythm; Female; Glasgow Coma Scale; Greece; Human | 2006 |
Circadian rhythm sleep disorders following mild traumatic brain injury.
Topics: Adolescent; Adult; Body Temperature; Brain Injuries; Circadian Rhythm; Female; Humans; Male; Melaton | 2007 |
Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray.
Topics: Adult; Aged; Brain; Brain Injuries; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoprostanes; | 2008 |
Protective effect of melatonin in a model of traumatic brain injury in mice.
Topics: Animals; Antioxidants; Body Temperature; Brain Injuries; Cyclic N-Oxides; Disease Models, Animal; Do | 1998 |
Closed head injury in the rat induces whole body oxidative stress: overall reducing antioxidant profile.
Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Brain Injuries; Carnosine; Carotenoids; Free Radical Sc | 1999 |
Melatonin as a free radical scavenger in experimental head trauma.
Topics: Animals; Brain Injuries; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Malondialde | 1999 |
Preventive effect of several antioxidants after oxidative stress on rat brain homogenates.
Topics: Animals; Antioxidants; Benzenesulfonates; Brain; Brain Injuries; Butylated Hydroxytoluene; Carboline | 2000 |
Neuroprotective effect of melatonin on cortical impact injury in the rat.
Topics: Animals; Antioxidants; Brain Edema; Brain Injuries; Cerebral Cortex; Circadian Rhythm; Infusions, Pa | 2000 |
Melatonin protects against ischemia/reperfusion-induced oxidative damage to mitochondria in fetal rat brain.
Topics: Adenosine Diphosphate; Animals; Brain; Brain Injuries; Female; Fetus; Melatonin; Oxidative Stress; O | 2001 |
[Cerebrospinal fluid melatonin in diseases of the nervous system].
Topics: Adolescent; Adult; Arachnoiditis; Brain Diseases; Brain Injuries; Brain Neoplasms; Epilepsy; Female; | 1977 |