melatonin has been researched along with Brain Injuries, Traumatic in 25 studies
Brain Injuries, Traumatic: A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the underlying mechanisms remain poorly understood." | 7.83 | Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy. ( Chao, H; Hou, L; Ji, J; Li, Z; Lin, C; Liu, N; Liu, Y; Xu, X, 2016) |
| "Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the underlying mechanisms remain poorly understood." | 3.83 | Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy. ( Chao, H; Hou, L; Ji, J; Li, Z; Lin, C; Liu, N; Liu, Y; Xu, X, 2016) |
| "Melatonin was shown to be beneficial to sleep quality, sleep duration, and sleep efficiency." | 3.01 | The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review. ( Browne, G; Cassimatis, M; Orr, R, 2023) |
| "Melatonin is a neurohormone released by the pineal gland." | 2.82 | Melatonin and the Brain-Heart Crosstalk in Neurocritically Ill Patients-From Molecular Action to Clinical Practice. ( Bekała, A; Bielacz, M; Biernawska, J; Bohatyrewicz, R; Dabrowski, W; Jaroszyński, A; Kotfis, K; Płotek, W; Siwicka-Gieroba, D; Sołek-Pastuszka, J, 2022) |
| "Melatonin treatment had a favorable effect on neurological status, by an SMD of 1." | 2.61 | Melatonin as a Treatment after Traumatic Brain Injury: A Systematic Review and Meta-Analysis of the Pre-Clinical and Clinical Literature. ( Barlow, KM; Boyd, R; Esser, MJ; Veidt, M, 2019) |
| "Melatonin (MEL) is a hormone that is produced in the brain and is known to bind to MEL-specific receptors on neuronal membranes in several brain regions." | 2.58 | Melatonin as a Therapy for Traumatic Brain Injury: A Review of Published Evidence. ( Alexander, S; Conley, YP; Dixon, CE; McGreevy, E; Osier, N; Pham, L; Puccio, A; Ren, D, 2018) |
| "Melatonin has been indicated to exhibit neuroprotective activities." | 1.72 | A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. ( Balawi, E; Cheng, Y; Du, M; Fu, J; Liao, ZB; Tan, W; Wu, B; Wu, C; Yu, R; Zhou, Q, 2022) |
| "Melatonin has been well documented for its neuroprotective role through inhibiting oxidative stress against traumatic brain injury (TBI)." | 1.62 | Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation. ( Cai, K; Cao, R; Chen, M; Chen, Q; Li, L; Lu, J; Sheng, L; Wang, Y; Xu, G; Zhang, W, 2021) |
| "A melatonin rhythm was present in both groups, and no group differences were found on melatonin variables." | 1.56 | Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm. ( Bernard, F; Blais, H; Duclos, C; Dumont, M; Gosselin, N; Menon, DK; Paquet, J; Van der Maren, S, 2020) |
| "To clarify the state of CR in coma and to determine the chronological relationship between its recovery and consciousness after brain lesions, we conducted a longitudinal observational study investigating how the state of CR was chronologically related with the recovery of behavioural wakefulness, cognition and/or awareness." | 1.51 | Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients. ( Claustrat, B; Cotton, F; Dailler, F; Gobert, F; Gronfier, C; Luauté, J; Perrin, F; Raverot, V, 2019) |
| "Melatonin was administered 1, 24, 48 and 72 h after TBI through i." | 1.48 | Does the administration of melatonin during post-traumatic brain injury affect cytokine levels? ( Asadikorom, G; Dehghan, F; Khaksari, M; Najafi, A; Shahrokhi, N; Soltani, Z, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 15 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, R | 1 |
| Li, L | 2 |
| Zhang, W | 2 |
| Lu, J | 1 |
| Wang, Y | 3 |
| Chen, Q | 1 |
| Chen, M | 1 |
| Sheng, L | 1 |
| Cai, K | 1 |
| Xu, G | 1 |
| Lorente, L | 2 |
| Martín, MM | 2 |
| Ruiz, C | 1 |
| Abreu-González, P | 2 |
| Ramos-Gómez, L | 1 |
| Argueso, M | 2 |
| Sole-Violan, J | 2 |
| Cáceres, JJ | 2 |
| Jiménez, A | 2 |
| Wu, C | 1 |
| Du, M | 1 |
| Yu, R | 1 |
| Cheng, Y | 3 |
| Wu, B | 1 |
| Fu, J | 1 |
| Tan, W | 1 |
| Zhou, Q | 1 |
| Balawi, E | 1 |
| Liao, ZB | 1 |
| Xie, LL | 2 |
| Rui, C | 1 |
| Li, ZZ | 2 |
| Li, SS | 2 |
| Fan, YJ | 2 |
| Qi, MM | 2 |
| Bekała, A | 1 |
| Płotek, W | 1 |
| Siwicka-Gieroba, D | 1 |
| Sołek-Pastuszka, J | 1 |
| Bohatyrewicz, R | 1 |
| Biernawska, J | 1 |
| Kotfis, K | 1 |
| Bielacz, M | 1 |
| Jaroszyński, A | 1 |
| Dabrowski, W | 1 |
| Cassimatis, M | 1 |
| Browne, G | 1 |
| Orr, R | 1 |
| Gao, Y | 2 |
| Wang, T | 2 |
| Wu, Y | 3 |
| Zhu, L | 1 |
| Gu, Z | 2 |
| Cai, L | 1 |
| Zhang, Y | 2 |
| Gao, C | 2 |
| Li, J | 1 |
| Li, Q | 3 |
| Wang, Z | 4 |
| Wang, F | 2 |
| Luo, C | 2 |
| Tao, L | 2 |
| Duclos, C | 1 |
| Dumont, M | 1 |
| Paquet, J | 1 |
| Blais, H | 1 |
| Van der Maren, S | 1 |
| Menon, DK | 1 |
| Bernard, F | 1 |
| Gosselin, N | 1 |
| Salman, M | 1 |
| Kaushik, P | 1 |
| Tabassum, H | 1 |
| Parvez, S | 1 |
| Lim, MA | 1 |
| Pranata, R | 1 |
| Jabłońska, J | 1 |
| Kluska, M | 1 |
| Lin, XJ | 1 |
| Liu, R | 1 |
| Li, C | 1 |
| Yi, X | 2 |
| Fu, B | 1 |
| Walker, MJ | 1 |
| Xu, XM | 1 |
| Sun, G | 1 |
| Lin, CH | 1 |
| Lan, NSR | 1 |
| Yeap, BB | 1 |
| Fegan, PG | 1 |
| Green, G | 1 |
| Rankin, JM | 1 |
| Dwivedi, G | 1 |
| Habibi, A | 1 |
| Karami, S | 1 |
| Varmira, K | 1 |
| Hadadi, M | 1 |
| Zhang, M | 2 |
| Lan, X | 1 |
| Li, X | 1 |
| Zheng, J | 1 |
| Eskandari-Sedighi, G | 1 |
| Cortez, LM | 1 |
| Yang, J | 1 |
| Daude, N | 1 |
| Shmeit, K | 1 |
| Sim, V | 1 |
| Westaway, D | 1 |
| Weigand, S | 1 |
| O'Connor, M | 1 |
| Blažek, P | 1 |
| Kantenwein, V | 1 |
| Friedrich, L | 1 |
| Grebmer, C | 1 |
| Schaarschmidt, C | 1 |
| von Olshausen, G | 1 |
| Reents, T | 1 |
| Deisenhofer, I | 1 |
| Lennerz, C | 1 |
| Kolb, C | 1 |
| Iwata, H | 1 |
| Sassa, N | 1 |
| Kato, M | 1 |
| Murase, Y | 1 |
| Seko, S | 1 |
| Kawanishi, H | 1 |
| Hattori, R | 1 |
| Gotoh, M | 1 |
| Tsuzuki, T | 1 |
| Chen, D | 2 |
| Zhang, J | 3 |
| Chen, YP | 1 |
| Li, Y | 1 |
| Zhou, M | 1 |
| Waterhouse, GIN | 1 |
| Sun, J | 1 |
| Shi, W | 1 |
| Ai, S | 1 |
| Manne, ASN | 1 |
| Hegde, AR | 1 |
| Raut, SY | 1 |
| Rao, RR | 1 |
| Kulkarni, VI | 1 |
| Mutalik, S | 1 |
| Jafari, R | 1 |
| Hectors, SJ | 1 |
| Koehne de González, AK | 1 |
| Spincemaille, P | 1 |
| Prince, MR | 1 |
| Brittenham, GM | 1 |
| Rui, T | 1 |
| Wang, H | 1 |
| Fang, X | 1 |
| Ma, X | 1 |
| Chen, G | 1 |
| Song, S | 1 |
| Wang, C | 1 |
| Min, J | 1 |
| Chen, X | 1 |
| Ge, J | 1 |
| Ben, J | 1 |
| Song, X | 1 |
| Zou, L | 1 |
| Grima, NA | 3 |
| Rajaratnam, SMW | 2 |
| Mansfield, D | 3 |
| McKenzie, D | 2 |
| Ponsford, JL | 3 |
| Xi, YG | 1 |
| Fedele, B | 1 |
| Williams, G | 1 |
| Giles, R | 1 |
| Olver, J | 1 |
| Pérez-Cejas, A | 1 |
| Ramos, L | 1 |
| García-Marín, V | 1 |
| Dehghan, F | 1 |
| Shahrokhi, N | 2 |
| Khaksari, M | 1 |
| Soltani, Z | 1 |
| Asadikorom, G | 1 |
| Najafi, A | 1 |
| Sletten, TL | 1 |
| Spitz, G | 1 |
| Osier, N | 1 |
| McGreevy, E | 1 |
| Pham, L | 1 |
| Puccio, A | 1 |
| Ren, D | 1 |
| Conley, YP | 1 |
| Alexander, S | 1 |
| Dixon, CE | 1 |
| Barlow, KM | 1 |
| Esser, MJ | 1 |
| Veidt, M | 1 |
| Boyd, R | 1 |
| Gobert, F | 1 |
| Luauté, J | 1 |
| Raverot, V | 1 |
| Cotton, F | 1 |
| Dailler, F | 1 |
| Claustrat, B | 1 |
| Perrin, F | 1 |
| Gronfier, C | 1 |
| Rehman, SU | 1 |
| Ikram, M | 1 |
| Ullah, N | 1 |
| Alam, SI | 1 |
| Park, HY | 1 |
| Badshah, H | 1 |
| Choe, K | 1 |
| Kim, MO | 1 |
| Lin, C | 1 |
| Chao, H | 1 |
| Li, Z | 1 |
| Xu, X | 1 |
| Liu, Y | 1 |
| Hou, L | 1 |
| Liu, N | 1 |
| Ji, J | 1 |
| Wu, H | 1 |
| Shao, A | 1 |
| Zhao, M | 1 |
| Chen, S | 1 |
| Yu, J | 1 |
| Zhou, J | 1 |
| Liang, F | 1 |
| Shi, L | 1 |
| Dixon, BJ | 1 |
| Ling, C | 1 |
| Hong, Y | 1 |
| St Hilaire, MA | 1 |
| Rajaratnam, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Association of Anesthesia Technique With Morbidity and Mortality in Patients With COVID-19 and Surgery for Hip Fracture: a Retrospective Population Cohort Study[NCT05133648] | 1,000 participants (Anticipated) | Observational | 2023-01-05 | Active, not recruiting | |||
| Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit[NCT03659760] | 40 participants (Anticipated) | Interventional | 2018-09-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for melatonin and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Melatonin and the Brain-Heart Crosstalk in Neurocritically Ill Patients-From Molecular Action to Clinical Practice.
Topics: Antioxidants; Brain; Brain Injuries; Brain Injuries, Traumatic; Heart Diseases; Humans; Melatonin | 2022 |
The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review.
Topics: Adolescent; Adult; Anxiety; Brain Injuries, Traumatic; Humans; Melatonin; Sleep; Sleep Wake Disorder | 2023 |
Melatonin as a Therapy for Traumatic Brain Injury: A Review of Published Evidence.
Topics: Animals; Antioxidants; Brain Injuries, Traumatic; Humans; Melatonin; Neuroprotective Agents | 2018 |
Melatonin as a Treatment after Traumatic Brain Injury: A Systematic Review and Meta-Analysis of the Pre-Clinical and Clinical Literature.
Topics: Animals; Anti-Inflammatory Agents; Brain Injuries, Traumatic; Humans; Melatonin; Neuroprotective Age | 2019 |
2 trials available for melatonin and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Poorer sleep quality predicts melatonin response in patients with traumatic brain injury: findings from a randomized controlled trial.
Topics: Australia; Brain Injuries, Traumatic; Humans; Melatonin; Sleep Initiation and Maintenance Disorders; | 2021 |
Efficacy of melatonin for sleep disturbance following traumatic brain injury: a randomised controlled trial.
Topics: Actigraphy; Adult; Anxiety; Australia; Brain Injuries, Traumatic; Cross-Over Studies; Double-Blind M | 2018 |
19 other studies available for melatonin and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation.
Topics: Animals; Astrocytes; Brain Injuries, Traumatic; Cognitive Dysfunction; Male; Melatonin; Mice; Neurop | 2021 |
Serum melatonin levels in predicting mortality in patients with severe traumatic brain injury.
Topics: Brain Injuries; Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Melatonin; Neuroinflammatory | 2021 |
A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury.
Topics: Animals; Arachidonate 5-Lipoxygenase; Brain Injuries, Traumatic; Endoplasmic Reticulum Stress; Ferro | 2022 |
Melatonin mitigates traumatic brain injury-induced depression-like behaviors through HO-1/CREB signal in rats.
Topics: Animals; Brain Injuries, Traumatic; Cyclic AMP Response Element-Binding Protein; Depression; Heme Ox | 2022 |
Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Ferritins; Humans; Inflammation; Interleukin-33; Me | 2023 |
Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm.
Topics: Actigraphy; Adult; Brain Injuries; Brain Injuries, Traumatic; Circadian Clocks; Circadian Rhythm; Fe | 2020 |
Melatonin Provides Neuroprotection Following Traumatic Brain Injury-Promoted Mitochondrial Perturbation in Wistar Rat.
Topics: Animals; bcl-2-Associated X Protein; Behavior, Animal; Brain Edema; Brain Injuries, Traumatic; Caspa | 2021 |
Topics: Acute Coronary Syndrome; Adolescent; Adsorption; Adult; Aged; Animals; Aspergillus; Aspergillus oryz | 2021 |
Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury-induced ferroptosis.
Topics: Animals; Apoferritins; Blotting, Western; Brain Injuries, Traumatic; Ferroptosis; Immunohistochemist | 2021 |
Effect of melatonin on regeneration of cortical neurons in rats with traumatic brain injury.
Topics: Animals; Apoptosis; Brain; Brain Injuries, Traumatic; Melatonin; Neurons; Rats; Rats, Sprague-Dawley | 2020 |
Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in females.
Topics: Animals; Apoptosis; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Drug Synergism; Female | 2021 |
Assessing Sleep Architecture With Polysomnography During Posttraumatic Amnesia After Traumatic Brain Injury: A Pilot Study.
Topics: Adult; Aged; Amnesia; Brain Injuries, Traumatic; Feasibility Studies; Female; Humans; Male; Melatoni | 2021 |
Serum melatonin levels in survivor and non-survivor patients with traumatic brain injury.
Topics: Adult; Aged; Antioxidants; Brain Injuries, Traumatic; Female; Glasgow Coma Scale; Humans; Male; Mela | 2017 |
Does the administration of melatonin during post-traumatic brain injury affect cytokine levels?
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Anim | 2018 |
Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients.
Topics: Adult; Biomarkers; Brain Injuries, Traumatic; Circadian Rhythm; Cognition; Coma; Consciousness; Huma | 2019 |
Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling.
Topics: AMP-Activated Protein Kinase Kinases; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Anti | 2019 |
Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy.
Topics: Animals; Brain Injuries, Traumatic; Inflammation; Interleukin-1beta; Male; Melatonin; Mitophagy; Rat | 2016 |
Melatonin attenuates neuronal apoptosis through up-regulation of K(+) -Cl(-) cotransporter KCC2 expression following traumatic brain injury in rats.
Topics: Animals; Apoptosis; Brain Injuries, Traumatic; K Cl- Cotransporters; Male; MAP Kinase Signaling Syst | 2016 |
Circadian Melatonin Rhythm Following Traumatic Brain Injury.
Topics: Adult; Area Under Curve; Brain Injuries, Traumatic; Case-Control Studies; Circadian Rhythm; Female; | 2016 |