melatonin has been researched along with Brain Edema in 35 studies
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "BACKGROUND A mouse model of subarachnoid hemorrhage (SAH) investigated the effects of melatonin treatment on the generation of reactive oxygen species (ROS) and the activation of the SIRT3 gene in early brain injury (EBI)." | 7.88 | Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ( Chen, X; Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "BACKGROUND The aim of this study was to investigate whether melatonin is involved in brain injury following subarachnoid hemorrhage (SAH)." | 7.88 | Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage. ( Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults." | 7.85 | Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. ( Ding, X; Feng, X; Han, X; Li, YH; Liu, MH; Lv, Y; Sun, B; Wang, Y; Xu, LX, 2017) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 7.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "Melatonin is a strong anti-oxidant that has beneficial effects against early brain injury (EBI) following a subarachnoid hemorrhage (SAH) in rats; protection includes the reduction of both mortality and neurological deficits." | 7.80 | Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines. ( Chen, G; Chen, J; Gu, C; Li, J; Mo, H; Qian, C; Wang, L; Yan, F; Yan, W, 2014) |
| "Melatonin decreases brain edema, BBB permeability and ICP, but increases VCS after TBI." | 7.79 | Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses. ( Asadikram, G; Dehghan, F; Khaksari Hadad, M; Najafipour, H; Shahrokhi, N, 2013) |
| "The study was performed to investigate the effect of combination therapy with melatonin and dexamethasone (DEX) on brain injury in intracerebral hemorrhage (ICH) model in rats." | 7.75 | Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats. ( Li, ZQ; Liang, GB; Liu, YH; Xue, YX, 2009) |
| "The aim of this study was to compare the effects of mannitol and melatonin on brain edema secondary to trauma using magnetic resonance imaging (MRI)." | 7.74 | The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema. ( Ak, A; Bayir, A; Bodur, S; Cengiz, SL; Kara, H; Kireşi, DA; Koçak, S; Ozdinç, S, 2008) |
| " Since melatonin is a potent free radical scavenger and indirect antioxidant, the objective of this study was to evaluate whether melatonin administration would attenuate oxidative stress, brain edema, and neurological deficits in a rat model of ICH." | 7.74 | The antioxidant effects of melatonin after intracerebral hemorrhage in rats. ( Chen, W; Jadhav, V; Lekic, T; Martin, RD; Rojas, H; Tang, J; Titova, E; Zhang, J, 2008) |
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 5.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerful antioxidant effect." | 5.39 | Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia. ( Boşca, B; Crişan, D; Filip, A; Şovrea, A; Stan, N; Vornicescu, C; Yacoob, S, 2013) |
| "Melatonin is a strong antioxidant that has low toxicity and easily passes through the BBB." | 5.35 | Effects of melatonin in early brain injury following subarachnoid hemorrhage. ( Ayer, RE; Sugawara, T; Zhang, JH, 2008) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 5.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| " Melatonin may also reduce brain edema and exert neuroprotective effect on several central nervous system diseases through inhibition of inflammatory response." | 4.93 | Progress in Drug Treatment of Cerebral Edema. ( Chen, CB; Deng, YY; Fang, M; Han, QP; Shen, FC; Xie, D; Zeng, HK, 2016) |
| "BACKGROUND A mouse model of subarachnoid hemorrhage (SAH) investigated the effects of melatonin treatment on the generation of reactive oxygen species (ROS) and the activation of the SIRT3 gene in early brain injury (EBI)." | 3.88 | Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ( Chen, X; Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "BACKGROUND The aim of this study was to investigate whether melatonin is involved in brain injury following subarachnoid hemorrhage (SAH)." | 3.88 | Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage. ( Hang, C; Li, S; Sun, B; Yang, S, 2018) |
| "Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults." | 3.85 | Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. ( Ding, X; Feng, X; Han, X; Li, YH; Liu, MH; Lv, Y; Sun, B; Wang, Y; Xu, LX, 2017) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 3.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "Melatonin is a strong anti-oxidant that has beneficial effects against early brain injury (EBI) following a subarachnoid hemorrhage (SAH) in rats; protection includes the reduction of both mortality and neurological deficits." | 3.80 | Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines. ( Chen, G; Chen, J; Gu, C; Li, J; Mo, H; Qian, C; Wang, L; Yan, F; Yan, W, 2014) |
| "Melatonin decreases brain edema, BBB permeability and ICP, but increases VCS after TBI." | 3.79 | Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses. ( Asadikram, G; Dehghan, F; Khaksari Hadad, M; Najafipour, H; Shahrokhi, N, 2013) |
| "The study was performed to investigate the effect of combination therapy with melatonin and dexamethasone (DEX) on brain injury in intracerebral hemorrhage (ICH) model in rats." | 3.75 | Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats. ( Li, ZQ; Liang, GB; Liu, YH; Xue, YX, 2009) |
| "The aim of this study was to compare the effects of mannitol and melatonin on brain edema secondary to trauma using magnetic resonance imaging (MRI)." | 3.74 | The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema. ( Ak, A; Bayir, A; Bodur, S; Cengiz, SL; Kara, H; Kireşi, DA; Koçak, S; Ozdinç, S, 2008) |
| " Since melatonin is a potent free radical scavenger and indirect antioxidant, the objective of this study was to evaluate whether melatonin administration would attenuate oxidative stress, brain edema, and neurological deficits in a rat model of ICH." | 3.74 | The antioxidant effects of melatonin after intracerebral hemorrhage in rats. ( Chen, W; Jadhav, V; Lekic, T; Martin, RD; Rojas, H; Tang, J; Titova, E; Zhang, J, 2008) |
| "The results showed a trend in decreasing brain edema with lower doses of melatonin (5 mg/kg and 15 mg/ kg), however, high concentration of melatonin (150 mg/kg) significantly increased brain edema compared to all other groups." | 3.74 | The antioxidant effects of melatonin in surgical brain injury in rats. ( Ayer, R; Hyong, A; Jadhav, V; Lee, S; Lekic, T; Martin, R; Rojas, H; Stier, G; Zhang, JH, 2008) |
| "Melatonin was found to be neuroprotective in instances of cold-induced brain edema." | 3.71 | Effect of melatonin on cerebral edema in rats. ( Erbil, M; Görgülü, A; Kilinç, K; Palaoğlu, S; Sürücü, MT; Tuncel, M, 2001) |
| "Based on the causative factors cerebral edema is differentiated into cytotoxic cerebral edema, vasogenic cerebral edema, osmotic and interstitial cerebral edema." | 2.50 | Therapeutic implications of melatonin in cerebral edema. ( Kaur, C; Ling, EA; Rathnasamy, G, 2014) |
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 1.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Melatonin is a highly potent free radical scavenger that protects against ischemic stroke." | 1.42 | Effects of normobaric oxygen and melatonin on reperfusion injury: role of cerebral microcirculation. ( Beker, MC; Caglayan, AB; Caglayan, B; Hermann, DM; Kelestemur, T; Kilic, E; Kilic, U; Yalcin, E; Yulug, B, 2015) |
| "Melatonin (10mg/kg) was administered via an intraperitoneal (ip) injection at 0, 1, 2, 3, and 4h post-TBI." | 1.40 | Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism. ( Ding, K; Ding, Y; He, J; Li, T; Wang, H; Xu, J; Zhang, L; Zhou, M; Zhu, L, 2014) |
| "Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerful antioxidant effect." | 1.39 | Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia. ( Boşca, B; Crişan, D; Filip, A; Şovrea, A; Stan, N; Vornicescu, C; Yacoob, S, 2013) |
| "Melatonin treatment starting 1h after injury attenuated BBB disruption during focal ischemia, which is at least partly due to inhibition of MMP-9 activity." | 1.38 | Melatonin reduced the elevated matrix metalloproteinase-9 level in a rat photothrombotic stroke model. ( Jang, JW; Kim, HS; Kim, SH; Lee, JK; Lee, MC; Piao, MS, 2012) |
| "Total edema volume, as well as brain swelling, was greatly and significantly reduced by pre-treatment of AM (reduced by 53%)." | 1.37 | Pre-treatment of adrenomedullin suppresses cerebral edema caused by transient focal cerebral ischemia in rats detected by magnetic resonance imaging. ( Kondoh, T; Torii, K; Ueta, Y, 2011) |
| "Melatonin is a strong antioxidant that has low toxicity and easily passes through the BBB." | 1.35 | Effects of melatonin in early brain injury following subarachnoid hemorrhage. ( Ayer, RE; Sugawara, T; Zhang, JH, 2008) |
| "Melatonin treatment improved the penumbral CBF in the wild-type mice." | 1.33 | Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice. ( Cheung, RT; Huang, L; Li, G; Liu, S; Zou, LY, 2006) |
| "In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours." | 1.32 | Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. ( Cheung, RT; Pang, SF; Pei, Z, 2003) |
| "Melatonin was administered twice (6." | 1.32 | Melatonin suppresses cerebral edema caused by middle cerebral artery occlusion/reperfusion in rats assessed by magnetic resonance imaging. ( Kondoh, T; Nishino, H; Torii, K; Uneyama, H, 2004) |
| "Reduction of cerebral edema, an early symptom of ischemia, is one of the most important remedies for reducing subsequent chronic neural damage in stroke." | 1.31 | Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats. ( Kondoh, T; Nishino, H; Torii, K; Uneyama, H, 2002) |
| "Melatonin treatment increased survival and reduced hyperactivity linked to neurodegeneration induced by cerebral ischemia and reperfusion." | 1.31 | Protective effects of melatonin in ischemic brain injury. ( Barberi, I; Caputi, AP; Cordaro, S; Costantino, G; Cuzzocrea, S; De Sarro, A; Fulia, F; Gitto, E; Mazzon, E; Serraino, I, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (42.86) | 29.6817 |
| 2010's | 16 (45.71) | 24.3611 |
| 2020's | 4 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 1 |
| Wang, T | 2 |
| Jin, X | 1 |
| Wang, G | 1 |
| Zhao, F | 1 |
| Jin, Y | 1 |
| Gao, Y | 1 |
| Cheng, Y | 1 |
| Wu, Y | 3 |
| Zhu, L | 2 |
| Gu, Z | 1 |
| Cai, L | 1 |
| Zhang, Y | 2 |
| Gao, C | 1 |
| Li, L | 1 |
| Li, J | 2 |
| Li, Q | 1 |
| Wang, Z | 2 |
| Wang, Y | 2 |
| Wang, F | 1 |
| Luo, C | 1 |
| Tao, L | 1 |
| Salman, M | 1 |
| Kaushik, P | 1 |
| Tabassum, H | 1 |
| Parvez, S | 1 |
| Liu, L | 1 |
| Cao, Q | 1 |
| Gao, W | 1 |
| Li, B | 1 |
| Xia, Z | 1 |
| Zhao, B | 1 |
| Xu, LX | 1 |
| Lv, Y | 1 |
| Li, YH | 1 |
| Ding, X | 1 |
| Han, X | 1 |
| Liu, MH | 1 |
| Sun, B | 3 |
| Feng, X | 1 |
| Zhou, F | 1 |
| Dou, Y | 1 |
| Tian, X | 1 |
| Liu, C | 1 |
| Li, H | 1 |
| Shen, H | 1 |
| Chen, G | 2 |
| Yang, S | 2 |
| Chen, X | 1 |
| Li, S | 2 |
| Hang, C | 2 |
| Dehghan, F | 1 |
| Khaksari Hadad, M | 1 |
| Asadikram, G | 1 |
| Najafipour, H | 1 |
| Shahrokhi, N | 1 |
| Vornicescu, C | 1 |
| Boşca, B | 1 |
| Crişan, D | 1 |
| Yacoob, S | 1 |
| Stan, N | 1 |
| Filip, A | 1 |
| Şovrea, A | 1 |
| Bhattacharya, P | 1 |
| Pandey, AK | 1 |
| Paul, S | 1 |
| Patnaik, R | 1 |
| Ding, K | 1 |
| Wang, H | 1 |
| Xu, J | 1 |
| Li, T | 1 |
| Zhang, L | 1 |
| Ding, Y | 1 |
| He, J | 1 |
| Zhou, M | 1 |
| Rathnasamy, G | 1 |
| Ling, EA | 3 |
| Kaur, C | 3 |
| Chen, J | 1 |
| Qian, C | 1 |
| Mo, H | 1 |
| Gu, C | 1 |
| Yan, F | 1 |
| Yan, W | 1 |
| Wang, L | 1 |
| Beker, MC | 1 |
| Caglayan, AB | 1 |
| Kelestemur, T | 1 |
| Caglayan, B | 1 |
| Yalcin, E | 1 |
| Yulug, B | 1 |
| Kilic, U | 1 |
| Hermann, DM | 1 |
| Kilic, E | 1 |
| Deng, YY | 1 |
| Shen, FC | 1 |
| Xie, D | 1 |
| Han, QP | 1 |
| Fang, M | 1 |
| Chen, CB | 1 |
| Zeng, HK | 1 |
| Lee, S | 2 |
| Jadhav, V | 3 |
| Ayer, RE | 2 |
| Rojas, H | 3 |
| Hyong, A | 2 |
| Lekic, T | 3 |
| Tang, J | 2 |
| Zhang, JH | 3 |
| Chen, W | 1 |
| Titova, E | 1 |
| Martin, RD | 1 |
| Zhang, J | 1 |
| Bayir, A | 1 |
| Kireşi, DA | 1 |
| Kara, H | 1 |
| Cengiz, SL | 1 |
| Koçak, S | 1 |
| Ozdinç, S | 1 |
| Ak, A | 1 |
| Bodur, S | 1 |
| Li, ZQ | 1 |
| Liang, GB | 1 |
| Xue, YX | 1 |
| Liu, YH | 1 |
| Sugawara, T | 1 |
| Ayer, R | 1 |
| Stier, G | 1 |
| Martin, R | 1 |
| Kabadi, SV | 1 |
| Maher, TJ | 1 |
| Kondoh, T | 3 |
| Ueta, Y | 1 |
| Torii, K | 3 |
| Jang, JW | 1 |
| Lee, JK | 1 |
| Lee, MC | 1 |
| Piao, MS | 1 |
| Kim, SH | 1 |
| Kim, HS | 1 |
| Ismailoglu, O | 1 |
| Atilla, P | 1 |
| Palaoglu, S | 2 |
| Cakar, N | 1 |
| Yasar, U | 1 |
| Kilinc, K | 2 |
| Kaptanoglu, E | 1 |
| Uneyama, H | 2 |
| Nishino, H | 2 |
| Pei, Z | 1 |
| Pang, SF | 1 |
| Cheung, RT | 2 |
| Zou, LY | 1 |
| Liu, S | 1 |
| Li, G | 1 |
| Huang, L | 1 |
| Sivakumar, V | 2 |
| Lu, J | 1 |
| Tang, FR | 1 |
| Cuzzocrea, S | 1 |
| Costantino, G | 1 |
| Gitto, E | 1 |
| Mazzon, E | 1 |
| Fulia, F | 1 |
| Serraino, I | 1 |
| Cordaro, S | 1 |
| Barberi, I | 1 |
| De Sarro, A | 1 |
| Caputi, AP | 1 |
| Sarrafzadeh, AS | 1 |
| Thomale, UW | 1 |
| Kroppenstedt, SN | 1 |
| Unterberg, AW | 1 |
| Görgülü, A | 1 |
| Tuncel, M | 1 |
| Sürücü, MT | 1 |
| Erbil, M | 1 |
2 reviews available for melatonin and Brain Edema
| Article | Year |
|---|---|
Therapeutic implications of melatonin in cerebral edema.
Topics: Animals; Antioxidants; Brain; Brain Edema; Humans; Melatonin | 2014 |
Progress in Drug Treatment of Cerebral Edema.
Topics: Animals; Aquaporin 4; Brain; Brain Edema; Fluid Therapy; Humans; Mannitol; Melatonin; Neuroprotectiv | 2016 |
33 other studies available for melatonin and Brain Edema
| Article | Year |
|---|---|
Roles of Crosstalk between Astrocytes and Microglia in Triggering Neuroinflammation and Brain Edema Formation in 1,2-Dichloroethane-Intoxicated Mice.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Cell Polarity; Citrates; Ethylene Dich | 2021 |
Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Ferritins; Humans; Inflammation; Interleukin-33; Me | 2023 |
Melatonin Provides Neuroprotection Following Traumatic Brain Injury-Promoted Mitochondrial Perturbation in Wistar Rat.
Topics: Animals; bcl-2-Associated X Protein; Behavior, Animal; Brain Edema; Brain Injuries, Traumatic; Caspa | 2021 |
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.
Topics: Animals; Apoptosis; Brain Edema; Brain Ischemia; Cell Line; Cell Survival; Chromones; Diabetes Melli | 2021 |
Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins.
Topics: Animals; Animals, Newborn; Biomarkers; Blotting, Western; Brain Edema; Colonic Diseases; Edema; Hypo | 2017 |
Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury.
Topics: Animals; Annexin A5; Antioxidants; Apoptosis; Benzimidazoles; Brain Edema; Brain Injuries; Carbocyan | 2018 |
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
Topics: Animals; Apoptosis; Brain Edema; Brain Injuries; Cell Line, Tumor; Disease Models, Animal; Humans; M | 2018 |
Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage.
Topics: Animals; Apoptosis; Autophagy; Brain Edema; Brain Injuries; Male; Melatonin; Mice; Mice, Inbred C57B | 2018 |
Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Intracranial Pressure; Male; Malon | 2013 |
Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia.
Topics: Animals; Brain Edema; Capillaries; Cell Count; Cell Nucleus; Cell Shape; Cognition; Glial Fibrillary | 2013 |
Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia.
Topics: Animals; Antioxidants; Apoptosis; Aquaporin 4; Blotting, Western; Brain Edema; Brain Ischemia; Calci | 2014 |
Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism.
Topics: Active Transport, Cell Nucleus; Animals; Antioxidant Response Elements; Brain Edema; Brain Injuries; | 2014 |
Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines.
Topics: Animals; Brain Edema; Brain Injuries; Cytokines; Inflammation Mediators; Male; Melatonin; Rats; Rats | 2014 |
Effects of normobaric oxygen and melatonin on reperfusion injury: role of cerebral microcirculation.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; bcl-X Protein; Blood-Brain Barrier; Brain; Brain | 2015 |
Dual effects of melatonin on oxidative stress after surgical brain injury in rats.
Topics: Analysis of Variance; Animals; Brain; Brain Edema; Brain Injuries; Dose-Response Relationship, Drug; | 2009 |
The antioxidant effects of melatonin after intracerebral hemorrhage in rats.
Topics: Animals; Antioxidants; Basal Ganglia; Brain Edema; Cerebral Hemorrhage; Collagenases; Disease Models | 2008 |
The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Female; Intracranial Pressure; | 2008 |
Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Blood-Brain Barrier; Blotting, | 2009 |
Effects of melatonin in early brain injury following subarachnoid hemorrhage.
Topics: Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Male | 2008 |
The antioxidant effects of melatonin in surgical brain injury in rats.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Re | 2008 |
Posttreatment with uridine and melatonin following traumatic brain injury reduces edema in various brain regions in rats.
Topics: Animals; Brain Edema; Brain Injuries; Male; Melatonin; Rats; Rats, Sprague-Dawley; Uridine | 2010 |
Pre-treatment of adrenomedullin suppresses cerebral edema caused by transient focal cerebral ischemia in rats detected by magnetic resonance imaging.
Topics: Adrenomedullin; Animals; Brain; Brain Edema; Infarction, Middle Cerebral Artery; Magnetic Resonance | 2011 |
Melatonin reduced the elevated matrix metalloproteinase-9 level in a rat photothrombotic stroke model.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain Edema; Brain Ischemia; Disease Models, Animal; Drug | 2012 |
The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Drug Combinations; Lipid Peroxi | 2012 |
Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain Edema; Coloring Agents; Ischemic Attac | 2002 |
Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model.
Topics: Animals; Brain Edema; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Melatonin suppresses cerebral edema caused by middle cerebral artery occlusion/reperfusion in rats assessed by magnetic resonance imaging.
Topics: Animals; Brain Edema; Brain Ischemia; Corpus Striatum; Infarction, Middle Cerebral Artery; Magnetic | 2004 |
Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice.
Topics: Animals; Brain; Brain Edema; Cerebral Infarction; Cerebrovascular Circulation; Cyclooxygenase 1; Dis | 2006 |
Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum.
Topics: Animals; Aquaporin 4; Astrocytes; Biomarkers; Blood-Brain Barrier; Brain Edema; Capillary Permeabili | 2006 |
Melatonin attenuates hypoxia-induced ultrastructural changes and increased vascular permeability in the developing hippocampus.
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Blood-Brain Barrier; Brain Edema; Dendrites; Di | 2008 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scaveng | 2000 |
Neuroprotective effect of melatonin on cortical impact injury in the rat.
Topics: Animals; Antioxidants; Brain Edema; Brain Injuries; Cerebral Cortex; Circadian Rhythm; Infusions, Pa | 2000 |
Effect of melatonin on cerebral edema in rats.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Free Radical Scavengers; M | 2001 |