Page last updated: 2024-10-19

melatonin and Bone Cancer

melatonin has been researched along with Bone Cancer in 21 studies

Research Excerpts

ExcerptRelevanceReference
"Melatonin is recognized as an anti-angiogenic agent, but its function in the tumor microenvironment especially in osteosarcoma remains uncertain."7.96Melatonin regulates tumor angiogenesis via miR-424-5p/VEGFA signaling pathway in osteosarcoma. ( Anuradha, D; Raghunandhakumar, S; Saravanan, S; Vimalraj, S, 2020)
"To evaluate the effects of melatonin (Mel) combined with cis-platinum (DDP) or methotrexate (MTX) on the proliferation of osteosarcoma cell line SaOS-2, and to explore whether Mel combined with DDP or MTX could play a synergistic antitumor effect."7.81Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2. ( Wang, YP; Yang, ZP, 2015)
"Although bone cancer is relatively rare, it is a serious disease that often becomes metastatic, leading to an unsatisfactory prognosis."7.01Potential Mechanisms of Melatonin in Osteosarcoma and Bone-Related Neoplasms: Updated Review. ( Asemi, Z; Dana, PM; Reiter, RJ; Sadoughi, F; Yousefi, B, 2023)
"Melatonin treatment significantly downregulated the expression of lncRNA JPX in Saos-2, MG63 and U2OS cells."5.62Anticancer effects of melatonin via regulating lncRNA JPX-Wnt/β-catenin signalling pathway in human osteosarcoma cells. ( Du, J; Li, B; Li, Y; Zou, J, 2021)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Melatonin is recognized as an anti-angiogenic agent, but its function in the tumor microenvironment especially in osteosarcoma remains uncertain."3.96Melatonin regulates tumor angiogenesis via miR-424-5p/VEGFA signaling pathway in osteosarcoma. ( Anuradha, D; Raghunandhakumar, S; Saravanan, S; Vimalraj, S, 2020)
"To evaluate the effects of melatonin (Mel) combined with cis-platinum (DDP) or methotrexate (MTX) on the proliferation of osteosarcoma cell line SaOS-2, and to explore whether Mel combined with DDP or MTX could play a synergistic antitumor effect."3.81Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2. ( Wang, YP; Yang, ZP, 2015)
"Although bone cancer is relatively rare, it is a serious disease that often becomes metastatic, leading to an unsatisfactory prognosis."3.01Potential Mechanisms of Melatonin in Osteosarcoma and Bone-Related Neoplasms: Updated Review. ( Asemi, Z; Dana, PM; Reiter, RJ; Sadoughi, F; Yousefi, B, 2023)
"Melatonin was given orally at 20 mg/day in the evening for at least 2 months."2.70Anti-angiogenic activity of melatonin in advanced cancer patients. ( Bucovec, R; Conti, A; Lissoni, P; Maestroni, GJ; Malugani, F; Rovelli, F, 2001)
"Melatonin is an indole produced by the pineal gland at night under normal light or dark conditions, and its levels, which are higher in children than in adults, begin to decrease prior to the onset of puberty and continue to decline thereafter."2.66New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence. ( Hsieh, YH; Lin, CW; Lu, KH; Reiter, RJ; Su, SC; Yang, SF, 2020)
"Melatonin is known to inhibit cell proliferation in both tumor types."1.72Calcium acts as a central player in melatonin antitumor activity in sarcoma cells. ( Herrera, F; Martín, V; Puente-Moncada, N; Rodríguez, C; Sánchez-Sánchez, AM; Turos-Cabal, M, 2022)
" Furthermore, the non-cytolytic and non-cytotoxic metronomic hydroxyurea dosage increased the biological therapy outcome by strengthening antitumor capability."1.72A retrospective observational study on cases of osteosarcomas treated with a multitherapy: The rationale and effectiveness. ( Borghetto, V; Costanzo, E; Di Bella, G; Di Bella, L; Moscato, I, 2022)
"Melatonin treatment significantly downregulated the expression of lncRNA JPX in Saos-2, MG63 and U2OS cells."1.62Anticancer effects of melatonin via regulating lncRNA JPX-Wnt/β-catenin signalling pathway in human osteosarcoma cells. ( Du, J; Li, B; Li, Y; Zou, J, 2021)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's2 (9.52)18.2507
2000's1 (4.76)29.6817
2010's5 (23.81)24.3611
2020's12 (57.14)2.80

Authors

AuthorsStudies
MacDonald, IJ1
Tsai, HC1
Chang, AC2
Huang, CC1
Yang, SF5
Tang, CH2
Li, Y2
Zou, J1
Li, B1
Du, J1
Sánchez-Sánchez, AM1
Turos-Cabal, M1
Puente-Moncada, N1
Herrera, F1
Rodríguez, C1
Martín, V1
Hosseini, F1
Shanehbandi, D1
Soleimanpour, J1
Yousefi, B2
Alemi, F1
Dana, PM1
Sadoughi, F1
Reiter, RJ4
Asemi, Z1
Yang, C1
Kang, F1
Huang, X1
Zhang, W1
Wang, S1
Han, M1
Zhang, Z1
Li, J1
Di Bella, G1
Di Bella, L1
Borghetto, V1
Moscato, I1
Costanzo, E1
Huang, W1
Wu, X1
Zhao, Y1
Liu, Y1
Zhang, B1
Qiao, M1
Zhu, Z1
Zhao, Z1
Lu, KH3
Lin, RC1
Yang, JS1
Yang, WE1
Lin, CW2
Hsieh, YH2
Su, SC2
Vimalraj, S1
Saravanan, S1
Raghunandhakumar, S1
Anuradha, D1
Liu, PI1
Lai, JL1
Lin, TH1
Tsai, CH1
Chen, PC1
Jiang, YJ1
Lin, LW1
Huang, WC1
Lin, YC1
Chien, MH1
Liu, L1
Wang, T1
Yang, X1
Xu, C1
Liao, Z1
Wang, X1
Su, D1
Zhou, H1
Qiu, X1
Chen, Y1
Huang, D1
Lian, C1
Su, P1
Wang, YP1
Yang, ZP1
Altındal, DÇ1
Gümüşderelioğlu, M1
Lissoni, P2
Cazzaniga, M1
Tancini, G1
Scardino, E1
Musci, R1
Barni, S1
Maffezzini, M1
Meroni, T1
Rocco, F1
Conti, A2
Maestroni, G1
Panzer, A1
Rovelli, F1
Malugani, F1
Bucovec, R1
Maestroni, GJ1
Starr, KW1

Reviews

5 reviews available for melatonin and Bone Cancer

ArticleYear
Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis.
    International journal of molecular sciences, 2021, Aug-30, Volume: 22, Issue:17

    Topics: Animals; Antioxidants; Bone Neoplasms; Humans; Melatonin; Osteoclasts; Osteogenesis; Osteoporosis

2021
Potential Mechanisms of Melatonin in Osteosarcoma and Bone-Related Neoplasms: Updated Review.
    Mini reviews in medicinal chemistry, 2023, Volume: 23, Issue:3

    Topics: Antineoplastic Agents; Bone Neoplasms; Humans; Melatonin; Osteosarcoma; Sarcoma, Ewing

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma.
    Cells, 2019, 12-12, Volume: 8, Issue:12

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Drug

2019
New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence.
    Cancer metastasis reviews, 2020, Volume: 39, Issue:1

    Topics: Adolescent; Animals; Bone Neoplasms; Child; Humans; Melatonin; Muscle Neoplasms; Neoplasm Invasivene

2020

Trials

2 trials available for melatonin and Bone Cancer

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Anti-angiogenic activity of melatonin in advanced cancer patients.
    Neuro endocrinology letters, 2001, Volume: 22, Issue:1

    Topics: Adult; Aged; Bone Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; C

2001

Other Studies

15 other studies available for melatonin and Bone Cancer

ArticleYear
Anticancer effects of melatonin via regulating lncRNA JPX-Wnt/β-catenin signalling pathway in human osteosarcoma cells.
    Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:20

    Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Exp

2021
Calcium acts as a central player in melatonin antitumor activity in sarcoma cells.
    Cellular oncology (Dordrecht), 2022, Volume: 45, Issue:3

    Topics: Bone Neoplasms; Calcium; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal

2022
Melatonin Increases the Sensitivity of Osteosarcoma Cells to Chemotherapy Drug Cisplatin.
    Drug research, 2022, Volume: 72, Issue:6

    Topics: Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplas

2022
Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway.
    Neuropharmacology, 2022, 12-01, Volume: 220

    Topics: Analgesics; Animals; Bone Neoplasms; Cancer Pain; Cytokines; HMGB1 Protein; Interleukin-6; Male; Mel

2022
A retrospective observational study on cases of osteosarcomas treated with a multitherapy: The rationale and effectiveness.
    Neuro endocrinology letters, 2022, Sep-16, Volume: 43, Issue:3

    Topics: Antioxidants; Bone Neoplasms; Butyric Acid; Humans; Hydroxyurea; Melatonin; Osteosarcoma; Tretinoin

2022
Janus-Inspired Core-Shell Structure Hydrogel Programmatically Releases Melatonin for Reconstruction of Postoperative Bone Tumor.
    ACS applied materials & interfaces, 2023, Jan-18, Volume: 15, Issue:2

    Topics: Bone Neoplasms; Bone Regeneration; Humans; Hydrogels; Melatonin; Osteogenesis; Tissue Scaffolds

2023
Melatonin regulates tumor angiogenesis via miR-424-5p/VEGFA signaling pathway in osteosarcoma.
    Life sciences, 2020, Sep-01, Volume: 256

    Topics: Angiogenesis Inhibitors; Animals; Bone Neoplasms; Cell Line, Tumor; Chickens; Egg Yolk; Endothelial

2020
Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases.
    Oncogene, 2021, Volume: 40, Issue:8

    Topics: Animals; Bone Marrow Cells; Bone Neoplasms; Bone Resorption; Cell Differentiation; Disease Models, A

2021
Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway.
    Journal of pineal research, 2018, Volume: 65, Issue:3

    Topics: Adolescent; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Chemokine CCL24; Female; Humans; Melato

2018
MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated β-catenin signaling repression.
    Journal of pineal research, 2019, Volume: 67, Issue:2

    Topics: Animals; beta Catenin; Biomarkers, Tumor; Bone Neoplasms; Cell Line, Tumor; Chondroma; Female; Human

2019
Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2015, Volume: 37, Issue:2

    Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Flow Cytomet

2015
Melatonin releasing PLGA micro/nanoparticles and their effect on osteosarcoma cells.
    Journal of microencapsulation, 2016, Volume: 33, Issue:1

    Topics: Bone Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Humans; Lactic Acid; Melatonin; Nanop

2016
Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone.
    European urology, 1997, Volume: 31, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combi

1997
Melatonin in osteosarcoma: an effective drug?
    Medical hypotheses, 1997, Volume: 48, Issue:6

    Topics: Adolescent; Antineoplastic Agents; Bone Development; Bone Neoplasms; Child; Drug Therapy, Combinatio

1997
Hormonal imbalance and the sarcomata.
    The Australian and New Zealand journal of surgery, 1969, Volume: 39, Issue:2

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Bone Neoplasms; Child, Preschool;

1969