melatonin has been researched along with Biological Clock Disturbances in 148 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " We reviewed the literature on the role of melatonin and ramelteon in the prevention of sleep disturbances and delirium in intensive care units and analysed the methods of melatonin therapy in an ICU setting." | 9.05 | The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review. ( Cubała, WJ; Lewandowska, K; Małkiewicz, MA; Mędrzycka-Dąbrowska, WA; Siemiński, M; Winklewski, PJ, 2020) |
| " In this review, we summarize the different hypotheses on pathophysiology mechanisms underlying depressive disorders and put a special emphasis on the alterations of melatonin secretion and associated changes in biological rhythms that characterize mood disorders." | 8.89 | Biological rhythms and melatonin in mood disorders and their treatments. ( Hamon, M; Lanfumey, L; Mongeau, R, 2013) |
| "Using salivary dim light melatonin onset (DLMO) and actigraphy, our study sought to determine if Parkinson disease (PD) patients demonstrate circadian disturbance compared to healthy controls." | 7.80 | Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. ( Bolitho, SJ; Grunstein, RR; Hodges, JR; Lewis, SJ; Naismith, SL; Rajaratnam, SM; Rogers, N; Terpening, Z, 2014) |
| "Circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been studied in stomach cancer (n = 89) and colorectal cancer (n = 86) patients." | 7.78 | [Age-related changes of 6-sulphatoxymelatonin excretion in stomach and colorectal cancer patients]. ( Anisimov, VN; Arutiunian, AV; Ermachenkov, MN; Guliaev, AV; Miliutina, IuP, 2012) |
| " We assessed the association between ambient light and circadian melatonin release, measured by urinary 6-sulfatoxymelatonin (6-SMT), in medical intensive care unit (MICU) patients with severe sepsis." | 7.78 | Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion. ( Netzer, G; Scharf, SM; Shanholtz, C; Silhan, L; Terrin, M; Verceles, AC, 2012) |
| " In contrast, circadian rhythm was preserved in nonseptic ICU patients, indicating that impaired circadian melatonin secretion in septic patients is mainly related to the presence of severe sepsis and/or concomitant medication." | 7.71 | Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. ( Delle-Karth, G; Ferti, L; Koreny, M; Marktl, W; Mundigler, G; Siostrzonek, P; Steindl-Munda, P; Zehetgruber, M, 2002) |
| "Obesity has become an epidemic in industrialized and developing countries." | 6.48 | Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. ( Korkmaz, A; Ma, S; Reiter, RJ; Tan, DX, 2012) |
| "Circadian dysregulation has long been thought to be a key component in the pathophysiology of bipolar disorder (BD)." | 5.72 | Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study. ( Chan, JWY; Chan, NY; Feng, H; Ho, AW; Ho, CS; Lam, SP; Lei, B; Liu, Y; Merikangas, KR; Tsang, JCC; Wang, J; Wing, YK; Zhang, J, 2022) |
| "Depression has become one of the most commonly prevalent neuropsychiatric disorders, and the main characteristics of depression are sleep disorders and melatonin secretion disorders caused by circadian rhythm disorders." | 5.22 | Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment. ( Jiang, YJ; Liu, J; Wang, YH; Wang, YQ; Zhao, HQ; Zou, MS, 2022) |
| " We reviewed the literature on the role of melatonin and ramelteon in the prevention of sleep disturbances and delirium in intensive care units and analysed the methods of melatonin therapy in an ICU setting." | 5.05 | The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review. ( Cubała, WJ; Lewandowska, K; Małkiewicz, MA; Mędrzycka-Dąbrowska, WA; Siemiński, M; Winklewski, PJ, 2020) |
| "We conducted a review using Medline, ISI Database, EMBase, PsyInfo up to January 2015, using the following keywords combinations: "mood disorder", "bipolar disorder", "depression", "unipolar disorder", "major depressive disorder", "affective disorder", for psychiatric conditions; and "circadian rhythms", "circadian markers", "circadian gene", "clock gene", "melatonin" for circadian rhythms." | 4.91 | [Circadian markers and genes in bipolar disorder]. ( Belliviera, F; Boudebesse, C; Etain, B; Yeim, S, 2015) |
| "PubMed database was searched systematically for articles that were published on or before May 5, 2013, and were written in English using the terms bipolar disorder, clock genes, endogenous clock, molecular clock, biological rhythms, circadian, suprachiasmatic nucleus, circadian rhythm, melatonin, and sleep." | 4.90 | The relationship between bipolar disorder and biological rhythms. ( Gonzalez, R, 2014) |
| " In this review, we summarize the different hypotheses on pathophysiology mechanisms underlying depressive disorders and put a special emphasis on the alterations of melatonin secretion and associated changes in biological rhythms that characterize mood disorders." | 4.89 | Biological rhythms and melatonin in mood disorders and their treatments. ( Hamon, M; Lanfumey, L; Mongeau, R, 2013) |
| " We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol and melatonin), and we assess the implications for CT and adjustment to shiftwork and jet lag." | 4.88 | Circadian typology: a comprehensive review. ( Adan, A; Archer, SN; Di Milia, L; Hidalgo, MP; Natale, V; Randler, C, 2012) |
| " Persons who engage in nightshift work may exhibit altered nighttime melatonin levels and reproductive hormone profiles that could increase the risk of hormone-related diseases, including breast cancer." | 4.83 | Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle. ( Davis, S; Mirick, DK, 2006) |
| " Several mechanisms have been postulated to explain an association between night work and female breast cancer, but the most likely is suppression of the hormone melatonin by light exposure at night." | 3.91 | Shedding Light on the Association between Night Work and Breast Cancer. ( Cherrie, JW, 2019) |
| "Using salivary dim light melatonin onset (DLMO) and actigraphy, our study sought to determine if Parkinson disease (PD) patients demonstrate circadian disturbance compared to healthy controls." | 3.80 | Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. ( Bolitho, SJ; Grunstein, RR; Hodges, JR; Lewis, SJ; Naismith, SL; Rajaratnam, SM; Rogers, N; Terpening, Z, 2014) |
| " Moreover these rats exhibited anhedonia in a sucrose consumption test, and increased grooming in the open-field test, which reflects an anxiety-like condition." | 3.79 | Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat. ( Angeles-Castellanos, M; Escobar, C; Salgado-Delgado, R; Tapia-Osorio, A, 2013) |
| " We assessed the association between ambient light and circadian melatonin release, measured by urinary 6-sulfatoxymelatonin (6-SMT), in medical intensive care unit (MICU) patients with severe sepsis." | 3.78 | Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion. ( Netzer, G; Scharf, SM; Shanholtz, C; Silhan, L; Terrin, M; Verceles, AC, 2012) |
| "Circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been studied in stomach cancer (n = 89) and colorectal cancer (n = 86) patients." | 3.78 | [Age-related changes of 6-sulphatoxymelatonin excretion in stomach and colorectal cancer patients]. ( Anisimov, VN; Arutiunian, AV; Ermachenkov, MN; Guliaev, AV; Miliutina, IuP, 2012) |
| " In contrast, circadian rhythm was preserved in nonseptic ICU patients, indicating that impaired circadian melatonin secretion in septic patients is mainly related to the presence of severe sepsis and/or concomitant medication." | 3.71 | Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. ( Delle-Karth, G; Ferti, L; Koreny, M; Marktl, W; Mundigler, G; Siostrzonek, P; Steindl-Munda, P; Zehetgruber, M, 2002) |
| " We measured the circadian rhythms of plasma melatonin, serum cortisol, growth hormone (GH) and prolactin (PRL) in 26 patients with anorexia nervosa (AN), 27 with primary obesity (OB) and 7 with bulimia nervosa (BN)." | 3.69 | Circadian neuroendocrine functions in disorders of eating behavior. ( Ferrari, E; Fioravanti, M; Magri, F; Pontiggia, B; Rondanelli, M; Severgnini, S; Solerte, SB, 1997) |
| "Sleep disorders are prevalent in patients with a neurocognitive disorder, and diagnosis and treatment in these patients remain challenging in clinical practice." | 2.82 | [Sleep disorders in patients with a neurocognitive disorder]. ( Carrier, J; Dang-Vu, TT; Moderie, C, 2022) |
| "No mood disorders were detectable at baseline (HLM 8." | 2.73 | Effects of the heart-lung machine on melatonin metabolism and mood disturbances. ( Chenevard, R; Erne, P; Suter, Y, 2008) |
| "Sleep disorders are frequent and can have serious consequences on patients' health and quality of life." | 2.61 | Sleep Disorders. ( K Pavlova, M; Latreille, V, 2019) |
| "We also address whether circadian dysregulation provides vulnerability to onset of BSD and evidence for a new integration of reward and circadian dysregulation in BSD." | 2.55 | Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders. ( Alloy, LB; Boland, EM; Ng, TH; Titone, MK, 2017) |
| "Depression was more frequently associated with circadian alterations than euthymia." | 2.55 | Chronotype and circadian rhythm in bipolar disorder: A systematic review. ( Abreu, RLC; de Bruin, PFC; de Bruin, VMS; Linhares Neto, VB; Melo, MCA, 2017) |
| "Circadian rhythm sleep disorders are caused by the disturbance of sleep-wake regulation in the central nervous system, disturbed input into the sensory organs, and decreased social activities." | 2.50 | [Sleep problems in dementia]. ( Oka, Y, 2014) |
| "Pediatric insomnia is an extrinsic sleep disorder subdivided into two categories: behavioral insomnia and insomnia related to medical, neurological, and psychiatric diseases." | 2.50 | Pediatric insomnia: clinical, diagnosis, and treatment. ( Miano, S; Peraita-Adrados, R, 2014) |
| "Melatonin is a powerful free radical scavenger and protects the oocyte from oxidative stress, especially at the time of ovulation." | 2.50 | Melatonin and the circadian system: contributions to successful female reproduction. ( Reiter, RJ; Tamura, H; Tan, DX; Xu, XY, 2014) |
| "Delirium is a serious neuropsychiatric syndrome of acute onset that occurs in approximately one in five general hospital patients and is associated with serious adverse outcomes that include loss of adaptive function, persistent cognitive problems and increased mortality." | 2.49 | Delirium: a disturbance of circadian integrity? ( Adamis, D; Dunne, C; Fitzgerald, JM; Meagher, DJ; O'Regan, N; Timmons, S; Trzepacz, PT, 2013) |
| "Obesity has become an epidemic in industrialized and developing countries." | 2.48 | Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. ( Korkmaz, A; Ma, S; Reiter, RJ; Tan, DX, 2012) |
| "Melatonin is a highly pleiotropic signaling molecule, which is released as a hormone of the pineal gland predominantly during night." | 2.48 | Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. ( Hardeland, R, 2012) |
| "Patients with advanced lung cancer suffering greater circadian activity/sleep cycle disruption suffer greater interference with function, greater anxiety and depression, poorer nighttime sleep, greater daytime fatigue, and poorer quality of life than comparable patients who maintain good circadian integration." | 2.45 | Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms. ( Ansell, C; Braun, D; Du-Quiton, J; Ferrans, C; Grutsch, J; Hrushesky, WJ; Kidder, S; Levin, R; Lis, C; Oh, EY; Quiton, DF; Reynolds, J; Wood, P; Yang, X, 2009) |
| " So far not enough is known about the effects of long-term use and about the interaction of melatonin with pubertal development." | 2.43 | [Melatonin. Neurobiological background and neuropsychiatric application in children]. ( Debruyne, C, 2006) |
| "breast cancer in industrialized countries." | 2.43 | The anti-tumor activity of pineal melatonin and cancer enhancing life styles in industrialized societies. ( Bartsch, C; Bartsch, H, 2006) |
| " However, exogenous administration of melatonin in an attempt to achieve this goal may have an untoward effect given that pharmacologic dosing with melatonin has been shown to phase shift humans depending on the time of day it's given." | 2.43 | Artificial lighting in the industrialized world: circadian disruption and breast cancer. ( Stevens, RG, 2006) |
| "Melatonin is the treatment of choice for blind people with non-24 h sleep/wake disorder." | 2.42 | Optimization of light and melatonin to phase-shift human circadian rhythms. ( Skene, DJ, 2003) |
| "Melatonin is a neurohormone synthesized in the pineal gland during the dark period in all species, including humans." | 2.42 | Therapeutic perspectives for melatonin agonists and antagonists. ( Atkinson, J; Boutin, JA; Casteilla, L; Delagrange, P; Lesieur, D; Misslin, R; Pellissier, S; Pénicaud, L; Renard, P, 2003) |
| "Patients with dementias, such as Alzheimer's disease (AD), often have nocturnally disrupted sleep." | 2.42 | Sleep disorders in Alzheimer's disease and other dementias. ( Bliwise, DL, 2004) |
| "Decabromodiphenyl ethane (DBDPE) is a novel flame retardant that is widely used in plastics, electronic products, building materials and textiles." | 1.72 | Exogenous melatonin protects preimplantation embryo development from decabromodiphenyl ethane-induced circadian rhythm disorder and endogenous melatonin reduction. ( Feng, D; Feng, X; Qiu, J; Shi, F; Zhang, S; Zhao, X, 2022) |
| "Circadian dysregulation has long been thought to be a key component in the pathophysiology of bipolar disorder (BD)." | 1.72 | Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study. ( Chan, JWY; Chan, NY; Feng, H; Ho, AW; Ho, CS; Lam, SP; Lei, B; Liu, Y; Merikangas, KR; Tsang, JCC; Wang, J; Wing, YK; Zhang, J, 2022) |
| "This study has demonstrated that circadian rhythm disorders are responsible for changes in body composition, melatonin levels, and insulin resistance in women aged 31-40 years and may be a risk factor for cardiovascular disease and diabetes." | 1.62 | Effects of circadian rhythm disorder on body composition in women aged 31-40 years. ( Cao, Y; Dong, C; Duan, H; Han, M; Jia, Y; Kong, Y; Meng, R; Wang, K; Yang, Z, 2021) |
| "People with Parkinson's disease had significantly poorer sleep quality with higher subjective sleep scores (p < 0." | 1.56 | Melanopsin Cell Dysfunction is Involved in Sleep Disruption in Parkinson's Disease. ( Dumpala, S; Feigl, B; Kerr, GK; Zele, AJ, 2020) |
| "Melatonin treatment and, to a lesser extent, water restriction enhanced the 24-h component, suggesting a potential role in ameliorating the disruptive effects of shift work." | 1.56 | Melatonin alleviates circadian system disruption induced by chronic shifts of the light-dark cycle in Octodon degus. ( Bano-Otalora, B; Madrid, JA; Rol, MA, 2020) |
| "Melatonin is a chronobiotic treatment which also alleviates rapid eye movement (REM) sleep behavior disorder (RBD)." | 1.43 | Loss of REM sleep features across nighttime in REM sleep behavior disorder. ( Arnaldi, D; Arnulf, I; Latimier, A; Leu-Semenescu, S; Vidailhet, M, 2016) |
| "Melatonin treatment improved the regularity, fragmentation and amplitude of the RAR in senescent fish, and it also improved sleep efficiency." | 1.39 | Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin. ( Almaida-Pagán, PF; de Costa, J; Lucas-Sánchez, A; Madrid, JA; Martinez-Nicolas, A; Mendiola, P, 2013) |
| "The possibility that a portion of the breast cancer burden might be explained by the introduction and increasing use of electricity to light the night was suggested >20 years ago." | 1.35 | Light-at-night, circadian disruption and breast cancer: assessment of existing evidence. ( Stevens, RG, 2009) |
| "Five patients with generalized epilepsy underwent a protocol whereby their sleep/wake schedule was evenly distributed across the circadian cycle while undergoing full-montage electroencephalography and hourly plasma melatonin measurements." | 1.35 | Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? ( Bromfield, EB; Pavlova, MK; Scheer, FA; Shea, SA, 2009) |
| "As melatonin has a major role in the regulation of sleep and other cyclical bodily activities and its synthesis is directly regulated by the SCN, we postulated that disturbed SCN function is likely to give rise to abnormal melatonin secretion in HD." | 1.35 | Delayed onset of the diurnal melatonin rise in patients with Huntington's disease. ( Aziz, NA; Frölich, M; Pijl, H; Roelfsema, F; Roos, RA; Schröder-van der Elst, JP; van der Bent, C, 2009) |
| "Narcolepsy is characterized, beside other features, by excessive daytime sleepiness and disturbed sleep at night." | 1.35 | Circadian rhythm in salivary melatonin in narcoleptic patients. ( Blazejova, K; Hajek, I; Illnerova, H; Nevsimalova, S, 2008) |
| "Sleep disorders are interrelated with medical and psychiatric illnesses." | 1.35 | Sleep disorders: causes, effects, and solutions. ( Tibbitts, GM, 2008) |
| "Treatment of circadian rhythm disorders has led to the development of a new type of agent called "chronobiotics," among which melatonin is the prototype." | 1.33 | Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent. ( Cardinali, DP; Furio, AM; Reyes, MP, 2005) |
| "Effective treatments now exist for many sleep disorders, such as OSA and RLS, and a major breakthrough in the treatment of narcolepsy seems imminent." | 1.32 | Sleep disorders. ( Fisch, BJ; Olejniczak, PW, 2003) |
| "1." | 1.31 | Effect of melatonin on changes in locomotor activity rhythm of Syrian hamsters injected with beta amyloid peptide 25-35 in the suprachiasmatic nuclei. ( Brusco, LL; Caccuri, RL; Cardinali, DP; Castillo Thea, V; Cutrera, RA; Furio, AM; Pérez Lloret, S; Riccio, P, 2002) |
| "Analgesic overuse, insomnia, depression, and anxiety are disorders that are often comorbid with CM." | 1.31 | Hypothalamic involvement in chronic migraine. ( Abucham, J; Cipolla-Neto, J; Peres, MF; Sanchez del Rio, M; Seabra, ML; Silberstein, SD; Tufik, S; Zukerman, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.35) | 18.2507 |
| 2000's | 64 (43.24) | 29.6817 |
| 2010's | 66 (44.59) | 24.3611 |
| 2020's | 16 (10.81) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, F | 1 |
| Qiu, J | 1 |
| Zhang, S | 2 |
| Zhao, X | 2 |
| Feng, D | 1 |
| Feng, X | 1 |
| Moderie, C | 1 |
| Carrier, J | 1 |
| Dang-Vu, TT | 1 |
| Wang, YQ | 1 |
| Jiang, YJ | 1 |
| Zou, MS | 1 |
| Liu, J | 1 |
| Zhao, HQ | 1 |
| Wang, YH | 1 |
| Feng, H | 1 |
| Ho, AW | 1 |
| Lei, B | 1 |
| Chan, JWY | 1 |
| Wang, J | 1 |
| Liu, Y | 1 |
| Tsang, JCC | 1 |
| Chan, NY | 1 |
| Lam, SP | 1 |
| Merikangas, KR | 1 |
| Ho, CS | 1 |
| Zhang, J | 1 |
| Wing, YK | 1 |
| Hirayama, J | 1 |
| Hattori, A | 1 |
| Takahashi, A | 1 |
| Furusawa, Y | 1 |
| Tabuchi, Y | 1 |
| Shibata, M | 1 |
| Nagamatsu, A | 1 |
| Yano, S | 1 |
| Maruyama, Y | 1 |
| Matsubara, H | 1 |
| Sekiguchi, T | 1 |
| Suzuki, N | 1 |
| Giordano, A | 1 |
| Duffy, J | 1 |
| Epstein, LJ | 1 |
| Pavlova, MK | 2 |
| Chen, XQ | 1 |
| Jiang, XM | 1 |
| Zheng, QX | 1 |
| Wang, HW | 1 |
| Xue, H | 1 |
| Pan, YQ | 1 |
| Liao, YP | 1 |
| Gao, XX | 1 |
| Bano-Otalora, B | 1 |
| Madrid, JA | 4 |
| Rol, MA | 2 |
| Pinato, L | 1 |
| Galina Spilla, CS | 1 |
| Markus, RP | 1 |
| da Silveira Cruz-Machado, S | 1 |
| Anderson, G | 1 |
| Rodriguez, M | 1 |
| Reiter, RJ | 7 |
| Huang, Y | 1 |
| Xu, C | 1 |
| He, M | 1 |
| Huang, W | 1 |
| Wu, K | 1 |
| Lewandowska, K | 1 |
| Małkiewicz, MA | 1 |
| Siemiński, M | 1 |
| Cubała, WJ | 1 |
| Winklewski, PJ | 1 |
| Mędrzycka-Dąbrowska, WA | 1 |
| Socaciu, AI | 1 |
| Ionuţ, R | 1 |
| Socaciu, MA | 1 |
| Ungur, AP | 1 |
| Bârsan, M | 1 |
| Chiorean, A | 1 |
| Socaciu, C | 1 |
| Râjnoveanu, AG | 1 |
| Feigl, B | 1 |
| Dumpala, S | 1 |
| Kerr, GK | 1 |
| Zele, AJ | 1 |
| Hou, Y | 1 |
| Liu, L | 1 |
| Chen, X | 1 |
| Li, Q | 1 |
| Li, J | 1 |
| Wei, T | 1 |
| Li, C | 1 |
| Heng, Y | 1 |
| Gao, X | 1 |
| Zhang, G | 1 |
| Wang, H | 1 |
| Meng, Z | 1 |
| Zhang, Y | 1 |
| Hou, H | 1 |
| Wang, F | 1 |
| Xie, N | 1 |
| Wu, Y | 1 |
| Zhang, Q | 1 |
| Zhu, Y | 1 |
| Dai, M | 1 |
| Zhou, J | 1 |
| Pan, J | 1 |
| Tang, M | 1 |
| Cheng, Q | 1 |
| Shi, B | 1 |
| Guo, Q | 1 |
| Li, X | 1 |
| Xie, L | 1 |
| Wang, B | 1 |
| Yang, D | 1 |
| Weng, Q | 1 |
| Guo, L | 1 |
| Ye, J | 1 |
| Pan, M | 1 |
| Zhou, H | 1 |
| Zhen, C | 1 |
| Liu, P | 1 |
| Ning, K | 1 |
| Brackenridge, L | 1 |
| Hardiman, PJ | 1 |
| Qu, F | 1 |
| Meng, R | 1 |
| Cao, Y | 1 |
| Kong, Y | 1 |
| Wang, K | 1 |
| Yang, Z | 1 |
| Jia, Y | 1 |
| Dong, C | 1 |
| Duan, H | 1 |
| Han, M | 1 |
| Alloy, LB | 1 |
| Ng, TH | 1 |
| Titone, MK | 1 |
| Boland, EM | 1 |
| Wendeu-Foyet, MG | 1 |
| Menegaux, F | 1 |
| Gubin, DG | 1 |
| Weinert, D | 1 |
| Báez-Ruiz, A | 1 |
| Guerrero-Vargas, NN | 1 |
| Cázarez-Márquez, F | 1 |
| Sabath, E | 1 |
| Basualdo, MDC | 1 |
| Salgado-Delgado, R | 2 |
| Escobar, C | 2 |
| Buijs, RM | 1 |
| Bauer, M | 1 |
| Glenn, T | 1 |
| Monteith, S | 1 |
| Gottlieb, JF | 1 |
| Ritter, PS | 1 |
| Geddes, J | 1 |
| Whybrow, PC | 1 |
| Block, KI | 1 |
| Burish, MJ | 1 |
| Chen, Z | 1 |
| Yoo, SH | 1 |
| Ouitou, Y | 1 |
| K Pavlova, M | 1 |
| Latreille, V | 1 |
| Manousakis, JE | 1 |
| Scovelle, AJ | 1 |
| Rajaratnam, SMW | 1 |
| Naismith, SL | 2 |
| Anderson, C | 1 |
| Madsen, MT | 1 |
| Gögenur, I | 2 |
| Resuehr, D | 1 |
| Wu, G | 1 |
| Johnson, RL | 1 |
| Young, ME | 1 |
| Hogenesch, JB | 1 |
| Gamble, KL | 1 |
| Cherrie, JW | 1 |
| Lucas-Sánchez, A | 1 |
| Almaida-Pagán, PF | 1 |
| Martinez-Nicolas, A | 2 |
| Mendiola, P | 1 |
| de Costa, J | 1 |
| Golombek, DA | 1 |
| Casiraghi, LP | 1 |
| Agostino, PV | 1 |
| Paladino, N | 1 |
| Duhart, JM | 1 |
| Plano, SA | 1 |
| Chiesa, JJ | 1 |
| Tapia-Osorio, A | 1 |
| Angeles-Castellanos, M | 1 |
| Fitzgerald, JM | 1 |
| Adamis, D | 1 |
| Trzepacz, PT | 1 |
| O'Regan, N | 1 |
| Timmons, S | 1 |
| Dunne, C | 1 |
| Meagher, DJ | 1 |
| van de Glind, EM | 1 |
| Vural, EM | 1 |
| Scholten, E | 1 |
| Hooft, L | 1 |
| Portegijs, E | 1 |
| van Munster, BC | 1 |
| de Rooij, SE | 1 |
| Datieva, VK | 1 |
| Rosinskaia, AV | 1 |
| Levin, OS | 1 |
| Miano, S | 1 |
| Peraita-Adrados, R | 1 |
| Gonzalez, R | 1 |
| Bolitho, SJ | 1 |
| Rajaratnam, SM | 1 |
| Grunstein, RR | 1 |
| Hodges, JR | 1 |
| Terpening, Z | 1 |
| Rogers, N | 1 |
| Lewis, SJ | 1 |
| Amaral, FG | 1 |
| Castrucci, AM | 1 |
| Cipolla-Neto, J | 2 |
| Poletini, MO | 1 |
| Mendez, N | 1 |
| Richter, HG | 1 |
| Sellix, MT | 1 |
| Tan, E | 1 |
| Scott, EM | 1 |
| Varcoe, TJ | 1 |
| Gatford, KL | 1 |
| Voultsios, A | 1 |
| Salkeld, MD | 1 |
| Boden, MJ | 1 |
| Rattanatray, L | 1 |
| Kennaway, DJ | 1 |
| Tamura, H | 1 |
| Tan, DX | 3 |
| Xu, XY | 1 |
| Duclos, C | 1 |
| Dumont, M | 1 |
| Wiseman-Hakes, C | 1 |
| Arbour, C | 1 |
| Mongrain, V | 1 |
| Gaudreault, PO | 1 |
| Khoury, S | 1 |
| Lavigne, G | 1 |
| Desautels, A | 1 |
| Gosselin, N | 1 |
| Gómez-Acebo, I | 1 |
| Dierssen-Sotos, T | 1 |
| Papantoniou, K | 1 |
| García-Unzueta, MT | 1 |
| Santos-Benito, MF | 1 |
| Llorca, J | 1 |
| Nováková, M | 1 |
| Praško, J | 2 |
| Látalová, K | 1 |
| Sládek, M | 1 |
| Sumová, A | 1 |
| Fifel, K | 1 |
| DeBoer, T | 1 |
| Videnovic, A | 1 |
| Breen, DP | 1 |
| Barker, RA | 1 |
| Zee, PC | 2 |
| Figueiro, MG | 1 |
| Plitnick, B | 1 |
| Rea, MS | 1 |
| Oka, Y | 1 |
| Gronfier, C | 1 |
| Kawada, T | 1 |
| Damasceno, A | 1 |
| Moraes, AS | 1 |
| Farias, A | 1 |
| Damasceno, BP | 1 |
| dos Santos, LM | 1 |
| Cendes, F | 1 |
| Billings, ME | 1 |
| Watson, NF | 1 |
| Madrid-Navarro, CJ | 1 |
| Sanchez-Galvez, R | 1 |
| Marina, R | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Auricular Acupuncture for Sleep Disturbances: A Randomized Control Trial[NCT04956341] | 316 participants (Anticipated) | Interventional | 2022-05-01 | Recruiting | |||
| Study of the Influence of an Osteopathic Treatment Protocol on the Improvement of Sleep: a Double-blind Randomized Controlled Trial[NCT05899972] | 50 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease[NCT04287543] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2021-05-31 | Withdrawn (stopped due to Due to the COVID-19 pandemic, we were unable to begin the study) | ||
| Trazodone vs. Quetiapine for the Treatment of ICU Delirium: A Prospective Observational Pilot Study[NCT05307003] | 60 participants (Anticipated) | Observational | 2023-04-01 | Recruiting | |||
| Comparison of Trazodone vs Quetiapine vs Placebo for the Treatment of ICU Delirium: A Randomized Controlled Trial (The TraQ Study)[NCT05085808] | Phase 4 | 30 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | ||
| Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial[NCT03624595] | 502 participants (Anticipated) | Interventional | 2019-04-16 | Active, not recruiting | |||
| Diet and Chronotype: a Randomized Controlled Trial to Evaluate the Effects of a Chronotype-adapted Diet on Weight Loss in Overweight/Obese Subjects[NCT05941871] | 150 participants (Anticipated) | Interventional | 2023-03-06 | Recruiting | |||
| Circadian Health in Patients Admitted to Intensive Care Units and Hospitalization (CHRONOHOSPI)[NCT04113876] | 975 participants (Actual) | Observational [Patient Registry] | 2019-01-01 | Completed | |||
| A Randomized, Double-Blind, Controlled Trial of Bright Light Therapy on All-Cause Excessive Daytime Sleepiness in Prader-Willi Syndrome[NCT05939453] | 30 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | |||
| Effects of Shift Work on Health: Assessment of Sleep Quality, Motor Control and Cardiovascular Risk.[NCT03453398] | 71 participants (Actual) | Interventional | 2018-01-23 | Completed | |||
| Regulating Mood and Suicidal Ideation With Morning Light Exposure Treatment[NCT05616819] | 480 participants (Anticipated) | Interventional | 2023-03-01 | Not yet recruiting | |||
| Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars[NCT01169233] | 25 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)[NCT05965609] | 60 participants (Anticipated) | Interventional | 2023-12-08 | Recruiting | |||
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
70 reviews available for melatonin and Biological Clock Disturbances
| Article | Year |
|---|---|
[Sleep disorders in patients with a neurocognitive disorder].
Topics: Alzheimer Disease; Chronobiology Disorders; Humans; Melatonin; REM Sleep Behavior Disorder; Restless | 2022 |
Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment.
Topics: Animals; Antidepressive Agents; Antioxidants; Benzofurans; Chronobiology Disorders; Cyclopropanes; D | 2022 |
Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure.
Topics: Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Humans; Melatonin; Radiation Injuries; | 2023 |
Dysregulation of Circadian Rhythms in Autism Spectrum Disorders.
Topics: Autism Spectrum Disorder; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Sleep Wake D | 2019 |
Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells.
Topics: Animals; Butyrates; Ceramides; Chronobiology Disorders; Gastrointestinal Microbiome; Humans; Immunit | 2019 |
The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review.
Topics: Chronobiology Disorders; Delirium; Humans; Indenes; Intensive Care Units; Melatonin; Receptors, Mela | 2020 |
Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases.
Topics: Aging; Animals; Chronobiology Disorders; Humans; Melatonin; Metabolic Networks and Pathways; Metabol | 2020 |
Association between circadian disruption and diseases: A narrative review.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Exercise; Humans; Melatonin; Phototherapy | 2020 |
Association between night-shift work and level of melatonin: systematic review and meta-analysis.
Topics: Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Middle Aged; Shift Work Schedule; Work | 2020 |
Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders.
Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Psychopathology; Sle | 2017 |
Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences.
Topics: Carcinogenesis; Cell Proliferation; Chronobiology Disorders; Circadian Rhythm; Circadian Rhythm Sign | 2017 |
[Temporal order deterioration and circadian disruption with age. 2. Systemic mechanisms and correction].
Topics: Age Factors; Aging; Chronobiology Disorders; Circadian Rhythm; Environment; Exercise; Humans; Light; | 2016 |
The potential influence of LED lighting on mental illness.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Humans; Light; Melatonin; Sleep Wake Disorders | 2018 |
Cluster Headache Is in Part a Disorder of the Circadian System.
Topics: Brain; Chronobiology Disorders; Circadian Rhythm; Cluster Headache; Humans; Melatonin; Nerve Net | 2018 |
Clock desynchronisation: why and how?
Topics: Alcohol Drinking; Animals; Chronobiology Disorders; Circadian Clocks; Drug-Related Side Effects and | 2015 |
Sleep Disorders.
Topics: Central Nervous System Depressants; Central Nervous System Stimulants; Chronobiology Disorders; Cogn | 2019 |
[Surgery and circadian disturbances].
Topics: Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Postoperative Complications; Surgical | 2018 |
The times they're a-changing: effects of circadian desynchronization on physiology and disease.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Phototherap | 2013 |
Delirium: a disturbance of circadian integrity?
Topics: Ataxia; Chronobiology Disorders; Cognition Disorders; Delirium; Humans; Melatonin; Models, Biologica | 2013 |
Pediatric insomnia: clinical, diagnosis, and treatment.
Topics: Adolescent; Behavior Therapy; Child; Child Behavior Disorders; Chronobiology Disorders; Cognition Di | 2014 |
The relationship between bipolar disorder and biological rhythms.
Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Genetic Predisposition to Disease; Huma | 2014 |
Environmental control of biological rhythms: effects on development, fertility and metabolism.
Topics: Animals; Biological Clocks; Brain; Child; Child Development; Chronobiology Disorders; Circadian Rhyt | 2014 |
Circadian rhythms, insulin action, and glucose homeostasis.
Topics: Animals; Blood Glucose; Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Diet, Carbohydr | 2014 |
Melatonin and the circadian system: contributions to successful female reproduction.
Topics: Animals; Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Female; Fetus; Humans; Light; | 2014 |
Sleep and wake disturbances following traumatic brain injury.
Topics: Blast Injuries; Brain Damage, Chronic; Brain Injuries; Chronobiology Disorders; Cognitive Behavioral | 2014 |
[Sleep problems in dementia].
Topics: Aged; Aged, 80 and over; Aging; Chronobiology Disorders; Circadian Rhythm; Dementia; Humans; Melaton | 2014 |
[Circadian clock and non-visual functions: the role of light in humans].
Topics: Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Hormones; Humans; Hypothalamus; Light; | 2014 |
Circadian dysrhythmias in the intensive care unit.
Topics: Central Nervous System Depressants; Chronobiology Disorders; Critical Illness; Humans; Intensive Car | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Keeping circadian time with hormones.
Topics: Chronobiology Disorders; Circadian Clocks; Ghrelin; Glucocorticoids; Hormones; Humans; Insulin; Lept | 2015 |
[Circadian markers and genes in bipolar disorder].
Topics: Biomarkers; Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Gene Expression Regulation; | 2015 |
Melatonin receptors as therapeutic targets in the suprachiasmatic nucleus.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Humans; Ligands; Melatonin; Molecular Targeted T | 2016 |
Chronotype and circadian rhythm in bipolar disorder: A systematic review.
Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Depression; Humans; Hydrocortisone; Mel | 2017 |
Circadian disruption of ICU patients: A review of pathways, expression, and interventions.
Topics: Chronobiology Disorders; Circadian Rhythm; Clinical Alarms; Critical Care; Critical Illness; Humans; | 2017 |
[Dysfunctions of biological clocks and their treatments].
Topics: Antioxidants; Biological Clocks; Chronobiology Disorders; Humans; Hypnotics and Sedatives; Melatonin | 2008 |
Melatonin as a biomarker of circadian dysregulation.
Topics: Biomarkers; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Humans; Light; Melatonin; P | 2008 |
A generalized theory of carcinogenesis due to chronodisruption.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Neoplasms | 2008 |
Defining chronodisruption.
Topics: Biological Clocks; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male | 2009 |
Defining chronodisruption.
Topics: Biological Clocks; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male | 2009 |
Defining chronodisruption.
Topics: Biological Clocks; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male | 2009 |
Defining chronodisruption.
Topics: Biological Clocks; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male | 2009 |
Bidirectional communication between sleep and circadian rhythms and its implications for depression: lessons from agomelatine.
Topics: Acetamides; Animals; Brain; Chronobiology Disorders; Circadian Rhythm; Depressive Disorder, Major; H | 2009 |
Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms.
Topics: Animals; Behavior Therapy; Chronobiology Disorders; Chronotherapy; Circadian Rhythm; Humans; Life St | 2009 |
[Shift and night work--is it a cancer risk factor?].
Topics: Breast Neoplasms; Causality; Chronobiology Disorders; Circadian Rhythm; Colorectal Neoplasms; Female | 2005 |
Postoperative circadian disturbances.
Topics: Body Temperature Regulation; Central Nervous System Depressants; Chronobiology Disorders; Cognition | 2010 |
Circadian rhythms, melatonin and depression.
Topics: Acetamides; Animals; Antidepressive Agents; Biological Clocks; Chronobiology Disorders; Depressive D | 2011 |
Novel melatonin-based therapies: potential advances in the treatment of major depression.
Topics: Acetamides; Antidepressive Agents; Chronobiology Disorders; Circadian Rhythm; Depressive Disorder, M | 2011 |
Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression.
Topics: Adolescent; Adult; Animals; Child; Chronobiology Disorders; Comorbidity; Disease Models, Animal; Hum | 2012 |
Bright-light therapy in the treatment of mood disorders.
Topics: Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Seasonal | 2011 |
Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction.
Topics: Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin | 2012 |
The role of melatonin treatment in chronic kidney disease.
Topics: Blood Pressure; Chronobiology Disorders; Chronotherapy; Humans; Inflammation Mediators; Kidney Failu | 2012 |
Circadian typology: a comprehensive review.
Topics: Aging; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Cognition; Feeding and Eating Di | 2012 |
Biological rhythms and melatonin in mood disorders and their treatments.
Topics: Acetamides; Animals; Antidepressive Agents; Brain; Chronobiology Disorders; Circadian Rhythm; Humans | 2013 |
Role of melatonin in the regulation of human circadian rhythms and sleep.
Topics: Body Temperature Regulation; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Sleep; Sl | 2003 |
Importance and relevance of melatonin to human biological rhythms.
Topics: Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Humans; Light; Melatonin; Pineal Gland | 2003 |
Optimization of light and melatonin to phase-shift human circadian rhythms.
Topics: Blindness; Chronobiology Disorders; Circadian Rhythm; Humans; Light; Melatonin; Phototherapy; Sleep | 2003 |
Therapeutic perspectives for melatonin agonists and antagonists.
Topics: Animals; Anxiety; Body Weight; Brain; Cerebrovascular Circulation; Chronobiology Disorders; Circadia | 2003 |
Circadian rhythmicity: from basic science to clinical approach.
Topics: Animals; Brain; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Sleep | 2000 |
Circadian rhythm sleep disorders.
Topics: Body Temperature; Chronobiology Disorders; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Photo | 2004 |
Sleep disorders in Alzheimer's disease and other dementias.
Topics: Accidental Falls; Alzheimer Disease; Antipsychotic Agents; Body Temperature Regulation; Chronobiolog | 2004 |
Sleep in acute care units.
Topics: Acute Disease; Chronobiology Disorders; Cues; Electroencephalography; Environment; Health Personnel; | 2006 |
Artificial lighting in the industrialized world: circadian disruption and breast cancer.
Topics: Alcohol Drinking; Animals; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Developing C | 2006 |
Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle.
Topics: Animals; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Electromagnetic Fields; Humans | 2006 |
The anti-tumor activity of pineal melatonin and cancer enhancing life styles in industrialized societies.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Proliferation; Chronobiology Disorders; Cir | 2006 |
Melatonin and human rhythms.
Topics: Biological Clocks; Chronobiology Disorders; Chronobiology Phenomena; Circadian Rhythm; Humans; Light | 2006 |
[Melatonin. Neurobiological background and neuropsychiatric application in children].
Topics: Adolescent; Anticonvulsants; Child; Child Development; Chronobiology Disorders; Circadian Rhythm; Hu | 2006 |
[Synchronization and desynchronization of the biological clock in man].
Topics: Adult; Child; Chronobiology Disorders; Circadian Rhythm; Homeostasis; Humans; Melatonin; Mental Diso | 2006 |
Light exposure, melatonin secretion, and menstrual cycle parameters: an integrative review.
Topics: Chronobiology Disorders; Circadian Rhythm; Clinical Nursing Research; Depression; Female; Follicle S | 2007 |
Visual impairment and circadian rhythm disorders.
Topics: Animals; Central Nervous System Depressants; Chronobiology Disorders; Humans; Melatonin; Vision Diso | 2007 |
Mechanisms and clinical significance of circadian rhythms in children.
Topics: Adolescent; Child; Child Development; Child, Preschool; Chronobiology Disorders; Circadian Rhythm; H | 2001 |
[Alcohol, chronobiology and sleep].
Topics: Alcoholism; Animals; Chronobiology Disorders; Ethanol; Humans; Melatonin; Sleep Wake Disorders | 2001 |
Circadian rhythms and circadian rhythm disorders in children and adolescents.
Topics: Adolescent; Antioxidants; Child; Child Development; Child, Preschool; Chronobiology Disorders; Circa | 2001 |
[Physiology of the biological clock and the relation of circadian rhythm disorders to illnesses].
Topics: Animals; Biological Clocks; Blindness; Chronobiology Disorders; Humans; Jet Lag Syndrome; Light; Mel | 1999 |
11 trials available for melatonin and Biological Clock Disturbances
| Article | Year |
|---|---|
Barriers to and facilitators of participation of older adults in a placebo-controlled randomized clinical trial.
Topics: Aged; Aged, 80 and over; Attitude to Health; Caregivers; Chronobiology Disorders; Comprehension; Del | 2013 |
[The use of melatonin in the treatment of chronic fatigue syndrome and circadian rhythm disorders in Parkinson's disease].
Topics: Central Nervous System Depressants; Chronobiology Disorders; Circadian Rhythm; Dose-Response Relatio | 2013 |
Rest-activity disturbances in children with septo-optic dysplasia characterized by actigraphy and 24-hour plasma melatonin profiles.
Topics: Actigraphy; Activity Cycles; Child; Child, Preschool; Chronobiology Disorders; Circadian Rhythm; Dia | 2010 |
Effectiveness of a red-visor cap for preventing light-induced melatonin suppression during simulated night work.
Topics: Analysis of Variance; Chronobiology Disorders; Clothing; Cross-Over Studies; Humans; Light; Male; Me | 2011 |
Beta 1-adrenergic antagonists and melatonin reset the clock and restore sleep in a circadian disorder, Smith-Magenis syndrome.
Topics: Abnormalities, Multiple; Acebutolol; Adolescent; Adrenergic beta-1 Receptor Antagonists; Adrenergic | 2003 |
Melatonin treatment in Smith Magenis syndrome.
Topics: Antioxidants; Chronobiology Disorders; Double-Blind Method; Humans; Intellectual Disability; Melaton | 2005 |
Sleep and wakefulness out of phase with internal biological time impairs learning in humans.
Topics: Adult; Attention; Chronobiology Disorders; Circadian Rhythm; Cognition; Female; Humans; Learning Dis | 2006 |
Circadian phase delay induced by phototherapeutic devices.
Topics: Adolescent; Adult; Aerospace Medicine; Analysis of Variance; Chronobiology Disorders; Fatigue; Femal | 2007 |
Effects of the heart-lung machine on melatonin metabolism and mood disturbances.
Topics: Aged; Cardiac Surgical Procedures; Chronobiology Disorders; Circadian Rhythm; Female; Heart-Lung Mac | 2008 |
Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work.
Topics: Adaptation, Physiological; Adult; Analysis of Variance; Chronobiology Disorders; Circadian Rhythm; D | 2001 |
Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin.
Topics: Area Under Curve; Biological Clocks; Blindness; Chronobiology Disorders; Circadian Rhythm; Drug Admi | 2001 |
67 other studies available for melatonin and Biological Clock Disturbances
| Article | Year |
|---|---|
Exogenous melatonin protects preimplantation embryo development from decabromodiphenyl ethane-induced circadian rhythm disorder and endogenous melatonin reduction.
Topics: Animals; Bromobenzenes; Chronobiology Disorders; Circadian Rhythm; Embryonic Development; Female; Me | 2022 |
Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study.
Topics: Adolescent; Bipolar Disorder; Case-Control Studies; Chronobiology Disorders; Circadian Rhythm; Human | 2022 |
Objective Diagnosis of Circadian Rhythm Disorders.
Topics: Chronobiology Disorders; Cognition; Humans; Melatonin; Movement; Sleep | 2023 |
Prevalence and risk factors of sub-health and circadian rhythm disorder of cortisol, melatonin, and temperature among Chinese midwives.
Topics: Chronobiology Disorders; Cross-Sectional Studies; East Asian People; Female; Humans; Hydrocortisone; | 2023 |
Melatonin alleviates circadian system disruption induced by chronic shifts of the light-dark cycle in Octodon degus.
Topics: Animals; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Male; Melatonin; Models, Anima | 2020 |
Saliva cortisol, melatonin levels and circadian rhythm alterations in Chinese primary school children with dyslexia.
Topics: Case-Control Studies; Child; China; Chronobiology Disorders; Circadian Rhythm; Dyslexia; Female; Hum | 2020 |
Melanopsin Cell Dysfunction is Involved in Sleep Disruption in Parkinson's Disease.
Topics: Actigraphy; Aged; Chronobiology Disorders; Female; Humans; Male; Melatonin; Middle Aged; Parkinson D | 2020 |
Association between circadian rhythm disruption and polycystic ovary syndrome.
Topics: Adult; Animals; Animals, Newborn; Chronobiology Disorders; Circadian Rhythm; Female; Granulosa Cells | 2021 |
Effects of circadian rhythm disorder on body composition in women aged 31-40 years.
Topics: Adult; Blood Pressure; Body Composition; Chronobiology Disorders; Circadian Rhythm; Female; Humans; | 2021 |
Food in synchrony with melatonin and corticosterone relieves constant light disturbed metabolism.
Topics: Adiposity; Animals; Chronobiology Disorders; Corticosterone; Fatty Liver; Feeding Methods; Glucose M | 2017 |
The Circadian System and Cancer: It's About Time!
Topics: Antineoplastic Agents; Chronobiology Disorders; Circadian Clocks; Circadian Rhythm; Humans; Melatoni | 2018 |
Advanced Circadian Timing and Sleep Fragmentation Differentially Impact on Memory Complaint Subtype in Subjective Cognitive Decline.
Topics: Aged; Chronobiology Disorders; Cognition Disorders; Female; Humans; Male; Melatonin; Memory Disorder | 2018 |
Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital Nurses.
Topics: Adult; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Female; Gene Expression Regulati | 2019 |
Shedding Light on the Association between Night Work and Breast Cancer.
Topics: Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Melatonin; Occupational | 2019 |
Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin.
Topics: Aging; Animals; Chronobiology Disorders; Circadian Rhythm; Cyprinodontiformes; Disease Progression; | 2013 |
Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat.
Topics: Analysis of Variance; Animals; Anxiety; Body Weight; Cell Count; Chronobiology Disorders; Corticoste | 2013 |
Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease.
Topics: Actigraphy; Antiparkinson Agents; Case-Control Studies; Chronobiology Disorders; Female; Humans; Lev | 2014 |
Rapidly alternating photoperiods disrupt central and peripheral rhythmicity and decrease plasma glucose, but do not affect glucose tolerance or insulin secretion in sheep.
Topics: Animals; Biomarkers; Blood Glucose; Body Temperature Regulation; Body Weight; Chronobiology Disorder | 2014 |
Association between exposure to rotating night shift versus day shift using levels of 6-sulfatoxymelatonin and cortisol and other sex hormones in women.
Topics: Adult; Analysis of Variance; Biomarkers; Chronobiology Disorders; Circadian Rhythm; Cross-Sectional | 2015 |
The circadian system of patients with bipolar disorder differs in episodes of mania and depression.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Chronobiology Disorders; Circadian Clocks; Circadian | 2015 |
The central clock in patients with Parkinson disease.
Topics: Chronobiology Disorders; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male; | 2014 |
The central clock in patients with Parkinson disease--reply.
Topics: Chronobiology Disorders; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male; | 2014 |
The effects of chronotype, sleep schedule and light/dark pattern exposures on circadian phase.
Topics: Adolescent; Adult; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Melatonin; Middle Aged | 2014 |
Sleep-onset tome by actigraphy in patients with Parkinson's disease.
Topics: Chronobiology Disorders; Female; Humans; Male; Melatonin; Parkinson Disease | 2015 |
Disruption of melatonin circadian rhythm production is related to multiple sclerosis severity: A preliminary study.
Topics: Adult; Chronobiology Disorders; Creatinine; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Me | 2015 |
Loss of REM sleep features across nighttime in REM sleep behavior disorder.
Topics: Adult; Aged; Chronobiology Disorders; Electromyography; Female; Humans; Male; Melatonin; Middle Aged | 2016 |
Sleep disorders: causes, effects, and solutions.
Topics: Behavior Therapy; Chronobiology Disorders; Drug Interactions; Drug-Related Side Effects and Adverse | 2008 |
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence.
Topics: Animals; Blindness; Breast Neoplasms; Chronobiology Disorders; Circadian Rhythm; Disease Models, Ani | 2009 |
Delayed onset of the diurnal melatonin rise in patients with Huntington's disease.
Topics: Chronobiology Disorders; Circadian Rhythm; Disease Progression; Down-Regulation; Female; Humans; Hun | 2009 |
Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome?
Topics: Adult; Aged; Aged, 80 and over; Chronobiology Disorders; Female; Humans; Liver Cirrhosis; Male; Mela | 2009 |
Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
Topics: Adolescent; Adult; Chronobiology Disorders; Circadian Rhythm; Electroencephalography; Epilepsy, Gene | 2009 |
Shift work and cancer - considerations on rationale, mechanisms, and epidemiology.
Topics: Breast Neoplasms; Chronobiology Disorders; Female; Humans; Male; Melatonin; Middle Aged; Occupationa | 2010 |
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Basal Nucleus of Meynert | 2011 |
Chronodisruption in lung cancer and possible therapeutic approaches.
Topics: Adenocarcinoma; Adult; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chronobiology Disor | 2011 |
Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronobiology Disorders; Circadian Rhythm; Critical Illn | 2012 |
Familial circadian rhythm disorder in the diurnal primate, Macaca mulatta.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Electroencephalography; Feeding Behavior; Macaca | 2012 |
When the circadian clock becomes a ticking time bomb.
Topics: Chronobiology Disorders; Circadian Clocks; Disease; Humans; Melatonin; Photoperiod; Pineal Gland; Ri | 2012 |
[Chronomedicine, circadian rhythms. Who may be interested?].
Topics: Antioxidants; Chronobiology Discipline; Chronobiology Disorders; Chronotherapy; Circadian Rhythm; Hu | 2012 |
[The role of melatonin in progress of pathology of a retina in patients of senior age group].
Topics: Age Factors; Aged; Antioxidants; Chronobiology Disorders; Environment; Female; Humans; Macular Degen | 2012 |
[Age-related changes of 6-sulphatoxymelatonin excretion in stomach and colorectal cancer patients].
Topics: Adult; Age Factors; Aged; Chronobiology Disorders; Circadian Rhythm; Colorectal Neoplasms; Female; H | 2012 |
Physiology. Setting the human clock: technique challenged.
Topics: Biological Clocks; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Controlled Clinical | 2002 |
Mood regulation in seasonal affective disorder patients and healthy controls studied in forced desynchrony.
Topics: Adult; Affect; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male; Me | 2003 |
Effect of melatonin on changes in locomotor activity rhythm of Syrian hamsters injected with beta amyloid peptide 25-35 in the suprachiasmatic nuclei.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Chronobiology Disorders; Circadian Rhythm; Cricet | 2002 |
Sleep disorders.
Topics: Adult; Aged; Antioxidants; Cheyne-Stokes Respiration; Chronobiology Disorders; Chronotherapy; Disord | 2003 |
[The effects of electrostimulation upon soldier's circadian of melatonin in plasma].
Topics: Adolescent; Adult; Chronobiology Disorders; Circadian Rhythm; Electric Stimulation; Humans; Male; Me | 2003 |
Circadian neuroendocrine functions in disorders of eating behavior.
Topics: Adult; Anorexia Nervosa; Chronobiology Disorders; Energy Intake; Female; Growth Hormone; Humans; Hyd | 1997 |
Eventual entrainment of the human circadian pacemaker by melatonin is independent of the circadian phase of treatment initiation: clinical implications.
Topics: Adult; Aged; Animals; Biological Clocks; Blindness; Chronobiology Disorders; Circadian Rhythm; Femal | 2004 |
Aging and vestibular system: specific tests and role of melatonin in cognitive involvement.
Topics: Accidental Falls; Aged; Aged, 80 and over; Aging; Cerebellum; Chronobiology Disorders; Cognition Dis | 2004 |
Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chronobiology Disorders; Female; Humans; Male; Melatonin | 2004 |
[Health problems due to night shift work and jetlag].
Topics: Accidents, Occupational; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Cross-Section | 2004 |
Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue.
Topics: Chronobiology Disorders; Circadian Rhythm; Clinical Trials as Topic; Environmental Exposure; Evidenc | 2004 |
Melatonin in humans: it's about time.
Topics: Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Pineal Gland; Time | 2005 |
Whiplash injury may deregulate the biological clock.
Topics: Brain; Chronobiology Disorders; Humans; Intracranial Aneurysm; Melatonin; Nerve Net; Pineal Gland; R | 2005 |
Timed melatonin treatment for delayed sleep phase syndrome: the importance of knowing circadian phase.
Topics: Antioxidants; Chronobiology Disorders; Chronobiology Phenomena; Cognition; Drug Administration Sched | 2005 |
Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent.
Topics: Aging; Animals; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Dementia; Humans; Mela | 2005 |
Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Headache Disorders, Primary; Humans; Hypothalamu | 2006 |
New-onset insomnia in a middle-aged woman.
Topics: Antioxidants; Chronobiology Disorders; Disorders of Excessive Somnolence; Female; Humans; Melatonin; | 2007 |
Sleep all day!
Topics: Chronobiology Disorders; Dietary Supplements; Humans; Melatonin; Sleep Wake Disorders; United States | 2006 |
Psychiatric research. Is internal timing key to mental health?
Topics: Animals; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Clinical Trials as Topic; Hum | 2007 |
Circadian rhythm in salivary melatonin in narcoleptic patients.
Topics: Adult; Biomarkers; Child; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male; Melatonin | 2008 |
Chronodisruption and melatonin: the need for sensible exposure metrics in epidemiological studies.
Topics: Chronobiology Disorders; Data Interpretation, Statistical; Epidemiologic Studies; Humans; Melatonin; | 2008 |
beta(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome.
Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Behavior; Child; Child, Preschool; Chromosomes, | 2001 |
[Can light exposure affect the risk of breast cancer? Female flight attendants and shift-workers probably the most vulnerable groups].
Topics: Aerospace Medicine; Breast Neoplasms; Chronobiology Disorders; Environmental Exposure; Female; Human | 2001 |
Hypothalamic involvement in chronic migraine.
Topics: Adult; Anxiety; Case-Control Studies; Chronic Disease; Chronobiology Disorders; Circadian Rhythm; Co | 2001 |
Plasma melatonin, pinealocyte morphology, and surface receptors/antigen expression on macrophages/microglia in the pineal gland following a high-altitude exposure.
Topics: Altitude Sickness; Animals; Antigens, Surface; Chronobiology Disorders; Circadian Rhythm; Histocompa | 2002 |
Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis.
Topics: Analysis of Variance; Case-Control Studies; Chronobiology Disorders; Female; Humans; Hypnotics and S | 2002 |
Intensive care unit sleep disruption: can the cycle be restored?
Topics: Chronobiology Disorders; Humans; Intensive Care Units; Melatonin; Sepsis | 2002 |