Page last updated: 2024-10-19

melatonin and Autism Spectrum Disorder

melatonin has been researched along with Autism Spectrum Disorder in 62 studies

Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)

Research Excerpts

ExcerptRelevanceReference
"Previous study showed that both melatonin supplement and physical exercise intervention could improve sleep quality in children with autism spectrum disorders (ASD) with the increase in endogenous melatonin level."9.51Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders. ( Cheng, JCH; Ho, AWY; Lai, EWH; Lau, EYY; Lee, PH; Tse, ACY, 2022)
"Robust clinical evidence has not been available for melatonin, a drug commonly administered for treating sleep problems of children with autism spectrum disorder (ASD)."9.51Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial. ( Fukumizu, M; Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O, 2022)
"A recent 3-month double-blind, placebo-controlled study demonstrated efficacy and safety of pediatric prolonged-release melatonin (PedPRM) for insomnia in children with autism spectrum disorder."9.41Sleep, Growth, and Puberty After 2 Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder. ( Breddy, J; Findling, RL; Gringras, P; Malow, BA; Maras, A; Nir, T; Schroder, CM; Zisapel, N, 2021)
"This study aimed to evaluate the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD)."9.41Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. ( He, R; Li, F; Li, W; Liu, Z; Shen, H; Wei, L; Xie, X; Xiong, M, 2023)
"Clinical evidence is required about the long-term efficacy and safety of melatonin treatment for sleep problems in children with neurodevelopmental disorders (NDDs) who underwent adequate sleep hygiene interventions."9.34Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders. ( Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Nagamitsu, S; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O; Yuge, K, 2020)
"5 years with Autism Spectrum Disorder or Smith-Magenis syndrome and insomnia demonstrated efficacy and safety of easily-swallowed prolonged-release melatonin mini-tablets (PedPRM; 2-5 mg) in improving sleep duration and onset."9.30Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life. ( Breddy, J; Findling, RL; Gringras, P; Malow, BA; Maras, A; Melmed, RD; Nir, T; Schroder, CM; Shahmoon, S; Zisapel, N, 2019)
"To assess the efficacy and safety of novel pediatric-appropriate, prolonged-release melatonin minitablets (PedPRM) versus placebo for insomnia in children and adolescents with autism spectrum disorder (ASD), with or without attention-deficit/hyperactivity disorder (ADHD) comorbidity, and neurogenetic disorders (NGD)."9.24Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. ( Breddy, J; Findling, RL; Frydman-Marom, A; Gringras, P; Nir, T, 2017)
"Melatonin preparations are emerging first-line pharmacotherapy for insomnia in children and adolescents with autism spectrum disorder (ASD), but quality, formulation, consistency, dosing, and limited long-term safety data are of concern."9.22Assessing the potential for drug interactions and long term safety of melatonin for the treatment of insomnia in children with autism spectrum disorder. ( Zisapel, N, 2022)
"The role of melatonin has been extensively investigated in pathophysiological conditions, including autism spectrum disorder (ASD)."9.12Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder. ( Anderson, GM; Bellissant, E; Chokron, S; Claustrat, B; Delorme, R; Denis, L; Fougerou-Leurent, C; Franco, P; Kermarrec, S; Lalanne, S; Nir, T; Schroder, CM; Tordjman, S, 2021)
"The aim of this review is to clarify the interrelationship between melatonin and autism spectrum disorder (ASD) during fetal development."8.98The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development. ( Choi, J; Hong, Y; Jin, Y; Won, J, 2018)
"Melatonin is one of the most used pharmacologic treatments for sleep problems in autism spectrum disorder, though its relationship with circadian and sleep parameters is still not well stablished."8.31Response to Melatonin Treatment in Children With Autism spectrum Disorder and Relationship to Sleep Parameters and Melatonin Levels. ( Garcés, C; Gavela-Pérez, T; Losada-Del Pozo, R; Martinez-Cayuelas, E; Merino-Andreu, M; Soriano-Guillén, L, 2023)
"Poor sleep quality is a major problem in patients with autism spectrum disorder (ASD), and is attributed to low melatonin levels."8.12Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study. ( Abraham, SJ; Balamurugan, M; Dedeepiya, VD; Ikewaki, N; Iwasaki, M; Kandaswamy, RS; Kurosawa, G; Preethy, S; Raghavan, K; Sonoda, T, 2022)
"Melatonin is accessed by almost one quarter of children on the autism spectrum in New Zealand, with higher observed rates among females and those aged between 5 and 11 years, of European ethnicity, and presenting with co-occurring mental health conditions."8.02Melatonin dispensing among New Zealand children aged 0-18 years with autism: a nationwide cross-sectional study. ( Bowden, N; Eggleston, MJF; McLay, LK; Schluter, PJ; Woodford, EC, 2021)
"Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with sleep disturbances that may result from abnormalities in melatonin production."7.91Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder. ( Babinska, K; Bartakovicova, K; Celusakova, H; Kemenyova, P; Siklenkova, L; Stebelova, K; Szapuova, Z; Vidosovicova, M; Waczulikova, I, 2019)
"This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters."7.85Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. ( Baker, EK; Hazi, A; Prendergast, LA; Richdale, AL, 2017)
"Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions."5.72Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022)
"Melatonin has also protective and antioxidant properties, so we can therefore hypothesize that alterations in melatonin's pathways may be one of the causes of the symptomatology of autism."5.72Role of melatonin in autism spectrum disorders in a male murine transgenic model: Study in the prefrontal cortex. ( Aria, F; Bonini, SA; Bonomini, F; Borsani, E; Giugno, L; Maccarinelli, G; Mastinu, A; Memo, M; Premoli, M; Rezzani, R, 2022)
"Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors."5.56Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder. ( Block, GD; Colwell, CS; Ghiani, CA; Hitchcock, ON; In Kim, Y; Kim, YS; Loh, DH; Luk, SHC; MacDowell Kaswan, ZA; Tahara, Y; Wang, HB, 2020)
"Previous study showed that both melatonin supplement and physical exercise intervention could improve sleep quality in children with autism spectrum disorders (ASD) with the increase in endogenous melatonin level."5.51Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders. ( Cheng, JCH; Ho, AWY; Lai, EWH; Lau, EYY; Lee, PH; Tse, ACY, 2022)
"Robust clinical evidence has not been available for melatonin, a drug commonly administered for treating sleep problems of children with autism spectrum disorder (ASD)."5.51Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial. ( Fukumizu, M; Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O, 2022)
"Low melatonin levels are a frequent finding in ASD patients."5.48Low maternal melatonin level increases autism spectrum disorder risk in children. ( Braam, W; Curfs, L; Ehrhart, F; Maas, APHM; Smits, MG, 2018)
"Children with neurodevelopmental disorders are at risk of sleep problems, typically difficulty getting to sleep, sleep/wake rhythm disturbances and reduced duration of sleep (insomnia)."5.42Melatonin for sleep problems in children with neurodevelopmental disorders. ( , 2015)
"This study aimed to evaluate the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD)."5.41Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. ( He, R; Li, F; Li, W; Liu, Z; Shen, H; Wei, L; Xie, X; Xiong, M, 2023)
"Clinical evidence is required about the long-term efficacy and safety of melatonin treatment for sleep problems in children with neurodevelopmental disorders (NDDs) who underwent adequate sleep hygiene interventions."5.34Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders. ( Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Nagamitsu, S; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O; Yuge, K, 2020)
"To assess the efficacy and safety of novel pediatric-appropriate, prolonged-release melatonin minitablets (PedPRM) versus placebo for insomnia in children and adolescents with autism spectrum disorder (ASD), with or without attention-deficit/hyperactivity disorder (ADHD) comorbidity, and neurogenetic disorders (NGD)."5.24Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. ( Breddy, J; Findling, RL; Frydman-Marom, A; Gringras, P; Nir, T, 2017)
"Melatonin preparations are emerging first-line pharmacotherapy for insomnia in children and adolescents with autism spectrum disorder (ASD), but quality, formulation, consistency, dosing, and limited long-term safety data are of concern."5.22Assessing the potential for drug interactions and long term safety of melatonin for the treatment of insomnia in children with autism spectrum disorder. ( Zisapel, N, 2022)
"The role of melatonin has been extensively investigated in pathophysiological conditions, including autism spectrum disorder (ASD)."5.12Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder. ( Anderson, GM; Bellissant, E; Chokron, S; Claustrat, B; Delorme, R; Denis, L; Fougerou-Leurent, C; Franco, P; Kermarrec, S; Lalanne, S; Nir, T; Schroder, CM; Tordjman, S, 2021)
" The use of melatonin in children and adolescents with autism spectrum disorder has been well studied and is associated with a positive effect on sleep in this patient group."4.98[Pharmacotherapy for children and adolescents with sleep disorders: an overview]. ( Grau, K; Plener, PL, 2018)
"The aim of this review is to clarify the interrelationship between melatonin and autism spectrum disorder (ASD) during fetal development."4.98The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development. ( Choi, J; Hong, Y; Jin, Y; Won, J, 2018)
"The purpose of this manuscript is to review the evidence generated by clinical trials of pharmaceuticals in autism spectrum disorder (ASD), describe challenges in the conduct of such trials, and discuss future directions RECENT FINDINGS: Clinical trials in ASD have produced several compounds to adequately support the pharmacological treatment of associated symptom domains: attention deficit hyperactivity disorder (methylphenidate, atomoxetine, and alpha agonists), irritability/aggression (risperidone and aripiprazole), sleep (melatonin), and weight gain associated with atypical antipsychotic use (metformin)."4.98Clinical trials in autism spectrum disorder: evidence, challenges and future directions. ( Anagnostou, E, 2018)
"We developed methods for identifying people on the autism spectrum and defined their sleep problems using the key words, "sleep" or "melatonin", or International Classification of Diseases (ICD) codes."4.12Characterizing sleep disorders in an autism-specific collection of electronic health records. ( Davis, LK; Hucks, D; Johnston, R; Malow, BA; Maxwell-Horn, A; Niarchou, M; Singer, EV; Sutcliffe, JS, 2022)
"Poor sleep quality is a major problem in patients with autism spectrum disorder (ASD), and is attributed to low melatonin levels."4.12Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study. ( Abraham, SJ; Balamurugan, M; Dedeepiya, VD; Ikewaki, N; Iwasaki, M; Kandaswamy, RS; Kurosawa, G; Preethy, S; Raghavan, K; Sonoda, T, 2022)
"Melatonin is accessed by almost one quarter of children on the autism spectrum in New Zealand, with higher observed rates among females and those aged between 5 and 11 years, of European ethnicity, and presenting with co-occurring mental health conditions."4.02Melatonin dispensing among New Zealand children aged 0-18 years with autism: a nationwide cross-sectional study. ( Bowden, N; Eggleston, MJF; McLay, LK; Schluter, PJ; Woodford, EC, 2021)
"Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with sleep disturbances that may result from abnormalities in melatonin production."3.91Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder. ( Babinska, K; Bartakovicova, K; Celusakova, H; Kemenyova, P; Siklenkova, L; Stebelova, K; Szapuova, Z; Vidosovicova, M; Waczulikova, I, 2019)
"This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters."3.85Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. ( Baker, EK; Hazi, A; Prendergast, LA; Richdale, AL, 2017)
"Melatonin is a hormone that facilitates falling asleep and maintaining sleep and is also involved in the endogenous synchronization of internal biological clocks."3.11[Therapeutic approaches for sleep and rhythms disorders in children with ASD]. ( Broquère, MA; Claustrat, B; Delorme, R; Franco, P; Lecendreux, M; Schröder, CM; Tordjman, S, 2022)
"Many types of sleep disorders have been reported in ASD individuals, but still lack a comprehensive study and in-depth analysis."2.66Understanding the role of sleep and its disturbances in Autism spectrum disorder. ( Brown, GM; Cardinali, DP; Karthikeyan, R; Pandi-Perumal, SR; Shakunthala, V; Spence, DW, 2020)
"The consequences of insomnia, including issues with mood, behavior, and cognition, are discussed."2.53Pediatric Insomnia. ( Brown, KM; Malow, BA, 2016)
"Melatonin was prescribed to 52 children, all but one were extended-release preparations."1.91Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort. ( Benny, A; Hewertson, V; Hill, CM; Joels, H; Joseph, B; Marshall, A; Piantino, C; Postigo, B; Sharpe, A, 2023)
"Our study shows that insomnia is most prevalent in individuals with autism with several consequences on children and family behavior and quality of life."1.91Sleep disturbances in subjects with autism spectrum disorder: A parental perspective. ( Bernardi, K; Bruni, G; Bruni, O; Ferri, R; Panerai, S; Prono, F, 2023)
"Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions."1.72Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022)
"Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors."1.56Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder. ( Block, GD; Colwell, CS; Ghiani, CA; Hitchcock, ON; In Kim, Y; Kim, YS; Loh, DH; Luk, SHC; MacDowell Kaswan, ZA; Tahara, Y; Wang, HB, 2020)
"Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity."1.56Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism. ( Abel, EA; Mannin, OR; Marceau, K; Schwichtenberg, AJ, 2020)
"Low melatonin levels are a frequent finding in ASD patients."1.48Low maternal melatonin level increases autism spectrum disorder risk in children. ( Braam, W; Curfs, L; Ehrhart, F; Maas, APHM; Smits, MG, 2018)
"Treatment of Autism Spectrum Disorders (ASD) is challenging."1.48Treating Children with ASD: The Perspective of Caregivers. ( Alessi-Severini, S; Breik, N; Bugden, S; Kuo, IF; Moffat, M, 2018)
"Children with neurodevelopmental disorders are at risk of sleep problems, typically difficulty getting to sleep, sleep/wake rhythm disturbances and reduced duration of sleep (insomnia)."1.42Melatonin for sleep problems in children with neurodevelopmental disorders. ( , 2015)

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's25 (40.32)24.3611
2020's37 (59.68)2.80

Authors

AuthorsStudies
Borsani, E1
Bonomini, F1
Bonini, SA1
Premoli, M1
Maccarinelli, G1
Giugno, L1
Mastinu, A1
Aria, F1
Memo, M1
Rezzani, R1
Tse, AC1
Lee, PH3
Zhang, J2
Chan, RC1
Ho, AW1
Lai, EW1
Schröder, CM5
Broquère, MA1
Claustrat, B2
Delorme, R4
Franco, P2
Lecendreux, M1
Tordjman, S2
Zisapel, N3
Singer, EV2
Niarchou, M2
Maxwell-Horn, A1
Hucks, D1
Johnston, R1
Sutcliffe, JS1
Davis, LK2
Malow, BA6
Tedroff, K1
von Euler, M1
Dahlén, E1
Tse, ACY2
Lau, EYY1
Cheng, JCH1
Ho, AWY1
Lai, EWH2
Bartakovicova, K2
Kemenyova, P2
Belica, I1
Janik Szapuova, Z1
Stebelova, K2
Waczulikova, I2
Ostatnikova, D1
Babinska, K2
Straub, P1
Raghavan, K1
Dedeepiya, VD1
Kandaswamy, RS1
Balamurugan, M1
Ikewaki, N1
Sonoda, T1
Kurosawa, G1
Iwasaki, M1
Preethy, S1
Abraham, SJ1
Dack, R1
Garstang, JJ1
Liu, X3
Cui, Y3
Zhang, Y3
Xiang, G3
Yu, M3
Wang, X5
Qiu, B3
Li, XG3
Liu, W3
Zhang, D3
Nogueira, HA1
de Castro, CT1
da Silva, DCG1
Pereira, M1
Bazin, B1
Geoffroy, PA1
Benzaquen, H1
Maruani, J1
Romier, A1
Lejoyeux, M1
D'ortho, MP1
Frija-Masson, J1
Xiong, M1
Li, F1
Liu, Z1
Xie, X1
Shen, H1
Li, W1
Wei, L1
He, R1
Martinez-Cayuelas, E1
Merino-Andreu, M1
Losada-Del Pozo, R1
Gavela-Pérez, T1
Garcés, C1
Soriano-Guillén, L1
Xu, M1
Wang, L2
Wang, Y1
Deng, J1
Wang, F1
Pan, S1
Zhao, Y1
Liao, A1
Chen, D1
Shen, J1
Yang, F1
Li, Y1
Wang, S1
Bernardi, K1
Prono, F1
Bruni, G1
Panerai, S1
Ferri, R1
Bruni, O2
Joels, H1
Benny, A1
Sharpe, A1
Postigo, B1
Joseph, B1
Piantino, C1
Marshall, A1
Hewertson, V1
Hill, CM2
Maes, M1
Anderson, G1
Betancort Medina, SR1
Seo, M1
Ojala, JO1
Pinato, L1
Galina Spilla, CS1
Markus, RP1
da Silveira Cruz-Machado, S1
Siklenkova, L1
Celusakova, H1
Vidosovicova, M1
Szapuova, Z1
Karthikeyan, R2
Cardinali, DP2
Shakunthala, V1
Spence, DW1
Brown, GM2
Pandi-Perumal, SR2
El-Ansary, A1
Hassan, WM1
Daghestani, M1
Al-Ayadhi, L1
Ben Bacha, A1
Findling, RL3
Maras, A2
Breddy, J3
Nir, T4
Gringras, P3
Yan, T1
Goldman, RD1
Averina, OV1
Kovtun, AS1
Polyakova, SI1
Savilova, AM1
Rebrikov, DV1
Danilenko, VN1
Wu, ZY1
Huang, SD1
Zou, JJ1
Wang, QX1
Naveed, M1
Bao, HN1
Wang, W1
Fukunaga, K1
Han, F1
Wang, HB1
Tahara, Y1
Luk, SHC1
Kim, YS1
Hitchcock, ON1
MacDowell Kaswan, ZA1
In Kim, Y1
Block, GD1
Ghiani, CA1
Loh, DH1
Colwell, CS1
Yuge, K1
Nagamitsu, S1
Ishikawa, Y2
Hamada, I2
Takahashi, H2
Sugioka, H2
Yotsuya, O2
Mishima, K2
Hayashi, M2
Yamashita, Y2
Yenen, AS1
Çak, HT1
Johnson, KP1
Zarrinnegar, P1
Lalanne, S1
Fougerou-Leurent, C1
Anderson, GM1
Chokron, S1
Bellissant, E1
Kermarrec, S1
Denis, L1
McLay, LK1
Schluter, PJ1
Eggleston, MJF1
Woodford, EC1
Bowden, N1
Fukumizu, M1
Moskaleva, PV1
Shnayder, NA1
Nasyrova, RF1
Banaschewski, T1
Fuentes, J1
Hvolby, A1
Posserud, MB1
Baker, EK1
Richdale, AL1
Hazi, A1
Prendergast, LA1
Pagan, C2
Goubran-Botros, H1
Benabou, M2
Lemière, N1
Murray, K1
Amsellem, F1
Callebert, J2
Chaste, P1
Jamain, S1
Fauchereau, F1
Huguet, G2
Maronde, E2
Leboyer, M2
Launay, JM1
Bourgeron, T2
Won, J2
Jin, Y2
Choi, J2
Park, S1
Lee, TH1
Lee, SR1
Chang, KT1
Hong, Y2
Frydman-Marom, A1
Howes, OD1
Rogdaki, M1
Findon, JL1
Wichers, RH1
Charman, T1
King, BH1
Loth, E1
McAlonan, GM1
McCracken, JT1
Parr, JR1
Povey, C1
Santosh, P1
Wallace, S1
Simonoff, E1
Murphy, DG1
Grau, K1
Plener, PL1
Rolland, T1
Leblond, CS1
Millot, GA1
Anagnostou, E1
Braam, W1
Ehrhart, F1
Maas, APHM1
Smits, MG1
Curfs, L1
Breik, N1
Kuo, IF1
Bugden, S1
Moffat, M1
Alessi-Severini, S1
Parker, A2
Beresford, B2
Dawson, V2
Elphick, H2
Fairhurst, C2
Hewitt, C2
Scantlebury, A2
Spiers, G2
Thomas, M2
Wright, K1
Mcdaid, C2
Abel, EA1
Schwichtenberg, AJ1
Mannin, OR1
Marceau, K1
Johansson, AEE1
Dorman, JS1
Chasens, ER1
Feeley, CA1
Devlin, B1
Missig, G1
McDougle, CJ1
Carlezon, WA1
Melmed, RD1
Shahmoon, S1
Brown, KM1
Gevi, F1
Zolla, L1
Gabriele, S1
Persico, AM1
Hellmer, K1
Nyström, P1
Cuomo, BM1
Vaz, S1
Lee, EAL1
Thompson, C1
Rogerson, JM1
Falkmer, T1
Goldman, SE1
Alder, ML1
Burgess, HJ1
Corbett, BA1
Hundley, R1
Wofford, D1
Fawkes, DB1
Laudenslager, ML1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Placebo-controlled Study to Investigate the Efficacy and Safety of Circadin® to Alleviate Sleep Disturbances in Children With Neurodevelopmental Disabilities[NCT01906866]Phase 3125 participants (Actual)Interventional2013-10-31Completed
Phase II/III Clinical Trial of NPC-15 - Verification of the Efficacy for Sleep Disorders of Children With Autism Spectrum Disorders -[NCT02757066]Phase 2/Phase 3196 participants (Actual)Interventional2016-06-16Completed
Examining the Association Between Physical Activity and Sleep Quality in Children With Autism Spectrum Disorder Using Melatonin-mediated Mechanism Model: A Randomized Controlled Trial[NCT03348982]32 participants (Anticipated)Interventional2018-01-31Not yet recruiting
Gut Mobilization With Oral Administration of Polyethylene Glycol (PEG) at the Dose of 6.9 g/d Once a Day for 6 Months in Chronically Constipated Autistic Children.[NCT05025553]21 participants (Actual)Interventional2018-01-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Sleep Latency Will be Measured for the Circadin 2/5 mg and Placebo by a Sleep and Nap Diary After 13 Weeks of Double-blind Treatment.

questionnaire - To compare the treatment effect of Circadin® 2/5 mg minitablets to that of placebo on sleep latency as derived from a Sleep and Nap Diary after 13 weeks of double-blind treatment (NCT01906866)
Timeframe: 13 weeks

Interventionminutes (Mean)
Circadin 2/5/10 mg-37.77
Placebo-12.57

The Total Sleep Time Will be Measured for the Circadin 2/5 mg and Placebo by a Sleep and Nap Diary Questionnaire After the 13 Week, Double-blind Treatment Period.

Total Sleep Time - To compare the treatment effect of Circadin® 2/5 mg minitablets to that of placebo on total sleep time (TST) as assessed by the Sleep and Nap Diary after 13 weeks of double-blind treatment (NCT01906866)
Timeframe: 13 weeks

Interventionminutes (Mean)
Circadin 2/5/10 mg51.03
Placebo18.71

Reviews

21 reviews available for melatonin and Autism Spectrum Disorder

ArticleYear
Assessing the potential for drug interactions and long term safety of melatonin for the treatment of insomnia in children with autism spectrum disorder.
    Expert review of clinical pharmacology, 2022, Volume: 15, Issue:2

    Topics: Adolescent; Autism Spectrum Disorder; Child; Delayed-Action Preparations; Drug Interactions; Humans;

2022
Melatonin for sleep disorders in people with autism: Systematic review and meta-analysis.
    Progress in neuro-psychopharmacology & biological psychiatry, 2023, 04-20, Volume: 123

    Topics: Autism Spectrum Disorder; Autistic Disorder; Humans; Melatonin; Polysomnography; Sleep; Sleep Wake D

2023
Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis.
    Neuropediatrics, 2023, Volume: 54, Issue:3

    Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep Duration; Sleep Initiation and Maintenance

2023
Integrating Autism Spectrum Disorder Pathophysiology: Mitochondria, Vitamin A, CD38, Oxytocin, Serotonin and Melatonergic Alterations in the Placenta and Gut.
    Current pharmaceutical design, 2019, Volume: 25, Issue:41

    Topics: ADP-ribosyl Cyclase 1; Autism Spectrum Disorder; Female; Humans; Melatonin; Mitochondria; Oxytocin;

2019
Dysregulation of Circadian Rhythms in Autism Spectrum Disorders.
    Current pharmaceutical design, 2019, Volume: 25, Issue:41

    Topics: Autism Spectrum Disorder; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Sleep Wake D

2019
Understanding the role of sleep and its disturbances in Autism spectrum disorder.
    The International journal of neuroscience, 2020, Volume: 130, Issue:10

    Topics: Autism Spectrum Disorder; Central Nervous System Depressants; Child; Humans; Melatonin; Sleep Wake D

2020
Autism spectrum disorder (ASD): Disturbance of the melatonin system and its implications.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 130

    Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Humans; Melatonin; Pineal Gland; Signal Transdu

2020
Melatonin and Circadian Rhythm in Autism Spectrum Disorders.
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2020,Fall, Volume: 31, Issue:3

    Topics: Autism Spectrum Disorder; Circadian Rhythm; Humans; Melatonin

2020
Autism Spectrum Disorder and Sleep.
    Child and adolescent psychiatric clinics of North America, 2021, Volume: 30, Issue:1

    Topics: Adolescent; Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep; Sleep Initiation and Maintena

2021
Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder.
    International journal of molecular sciences, 2021, Feb-02, Volume: 22, Issue:3

    Topics: Administration, Oral; Adult; Autism Spectrum Disorder; Biological Availability; Child; Child, Presch

2021
[Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2021, Volume: 121, Issue:5

    Topics: Acetylserotonin O-Methyltransferase; Aromatic-L-Amino-Acid Decarboxylases; Arylalkylamine N-Acetyltr

2021
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.
    International journal of molecular sciences, 2017, Jun-20, Volume: 18, Issue:6

    Topics: Anxiety; Autism Spectrum Disorder; Circadian Clocks; Circadian Rhythm; Fragile X Mental Retardation

2017
Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:1

    Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D

2018
[Pharmacotherapy for children and adolescents with sleep disorders: an overview].
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2018, Volume: 46, Issue:5

    Topics: Adolescent; Autism Spectrum Disorder; Child; Combined Modality Therapy; Comorbidity; Cross-Sectional

2018
The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development.
    Molecules (Basel, Switzerland), 2018, Jan-18, Volume: 23, Issue:1

    Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Female; Fetal Development; Humans; Maternal Exp

2018
Clinical trials in autism spectrum disorder: evidence, challenges and future directions.
    Current opinion in neurology, 2018, Volume: 31, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aggression; Antipsychotic Agents; Aripipraz

2018
Oral melatonin for non-respiratory sleep disturbance in children with neurodisabilities: systematic review and meta-analyses.
    Developmental medicine and child neurology, 2019, Volume: 61, Issue:8

    Topics: Actigraphy; Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep Wake Disorders; Treatment Outc

2019
Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD).
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020, Volume: 45, Issue:1

    Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Disease Models, Animal; Endpoint Determination;

2020
Outcome domains and outcome measures used in studies assessing the effectiveness of interventions to manage non-respiratory sleep disturbances in children with neurodisabilities: a systematic review.
    BMJ open, 2019, 06-19, Volume: 9, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous System Depr

2019
Pediatric Insomnia.
    Chest, 2016, Volume: 149, Issue:5

    Topics: Actigraphy; Adolescent; Amines; Anti-Anxiety Agents; Autism Spectrum Disorder; Central Nervous Syste

2016
Effectiveness of Sleep-Based Interventions for Children with Autism Spectrum Disorder: A Meta-Synthesis.
    Pharmacotherapy, 2017, Volume: 37, Issue:5

    Topics: Autism Spectrum Disorder; Behavior Therapy; Child; Early Medical Intervention; Humans; Melatonin; Sl

2017

Trials

8 trials available for melatonin and Autism Spectrum Disorder

ArticleYear
[Therapeutic approaches for sleep and rhythms disorders in children with ASD].
    L'Encephale, 2022, Volume: 48, Issue:3

    Topics: Adolescent; Autism Spectrum Disorder; Child; Humans; Melatonin; Quality of Life; Sleep; Sleep Initia

2022
Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders.
    PloS one, 2022, Volume: 17, Issue:7

    Topics: Autism Spectrum Disorder; Child; Exercise; Humans; Melatonin; Randomized Controlled Trials as Topic;

2022
Sleep, Growth, and Puberty After 2 Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2021, Volume: 60, Issue:2

    Topics: Adolescent; Aged, 80 and over; Autism Spectrum Disorder; Child; Double-Blind Method; Humans; Melaton

2021
Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders.
    BMC psychiatry, 2020, 09-10, Volume: 20, Issue:1

    Topics: Adolescent; Autism Spectrum Disorder; Child; Female; Humans; Japan; Male; Melatonin; Neurodevelopmen

2020
Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial.
    Journal of autism and developmental disorders, 2022, Volume: 52, Issue:6

    Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep; Sleep Hygiene; Sleep Wake Disorders

2022
Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2017, Volume: 56, Issue:11

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous

2017
Study protocol for a randomised controlled trial examining the association between physical activity and sleep quality in children with autism spectrum disorder based on the melatonin-mediated mechanism model.
    BMJ open, 2018, 04-13, Volume: 8, Issue:4

    Topics: Autism Spectrum Disorder; Child; Exercise; Humans; Melatonin; Randomized Controlled Trials as Topic;

2018
Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
    Journal of autism and developmental disorders, 2019, Volume: 49, Issue:8

    Topics: Adolescent; Autism Spectrum Disorder; Caregivers; Central Nervous System Depressants; Child; Child B

2019

Other Studies

33 other studies available for melatonin and Autism Spectrum Disorder

ArticleYear
Role of melatonin in autism spectrum disorders in a male murine transgenic model: Study in the prefrontal cortex.
    Journal of neuroscience research, 2022, Volume: 100, Issue:3

    Topics: Animals; Autism Spectrum Disorder; Brain; Humans; Male; Melatonin; Mice; Mice, Transgenic; Prefronta

2022
Effects of exercise on sleep, melatonin level, and behavioral functioning in children with autism.
    Autism : the international journal of research and practice, 2022, Volume: 26, Issue:7

    Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Exercise; Humans; Melatonin; Sleep; Sleep Wake D

2022
Characterizing sleep disorders in an autism-specific collection of electronic health records.
    Sleep medicine, 2022, Volume: 92

    Topics: Adolescent; Adult; Autism Spectrum Disorder; Autistic Disorder; Child; Electronic Health Records; Hu

2022
Melatonin usage in children and young adults, a registry-based cohort study.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2022, Volume: 39

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child; Cohort S

2022
Sleep Problems and 6-Sulfatoxymelatonin as Possible Predictors of Symptom Severity, Adaptive and Maladaptive Behavior in Children with Autism Spectrum Disorder.
    International journal of environmental research and public health, 2022, 06-21, Volume: 19, Issue:13

    Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep; Sleep Wake Disorders

2022
Investigating the genetic pathways of insomnia in Autism Spectrum Disorder.
    Research in developmental disabilities, 2022, Volume: 128

    Topics: Autism Spectrum Disorder; Child; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Initiation and Ma

2022
Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study.
    Brain and behavior, 2022, Volume: 12, Issue:9

    Topics: Animals; Autism Spectrum Disorder; beta-Glucans; Glucans; Humans; Melatonin; Pilot Projects; Prospec

2022
Use of melatonin: a single-centre audit.
    BMJ paediatrics open, 2022, Volume: 6, Issue:1

    Topics: Adolescent; Autism Spectrum Disorder; Child; Humans; Melatonin; Neurodevelopmental Disorders; Sleep

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode

2022
Continuous positive airway pressure as an accurate marker for non-24-hour sleep-wake rhythm disorder.
    Journal of sleep research, 2023, Volume: 32, Issue:4

    Topics: Autism Spectrum Disorder; Circadian Rhythm; Continuous Positive Airway Pressure; Humans; Male; Melat

2023
Response to Melatonin Treatment in Children With Autism spectrum Disorder and Relationship to Sleep Parameters and Melatonin Levels.
    Journal of child neurology, 2023, Volume: 38, Issue:5

    Topics: Adolescent; Autism Spectrum Disorder; Child; Circadian Rhythm; Humans; Melatonin; Sleep; Treatment O

2023
Melatonin ameliorates sleep-wake disturbances and autism-like behaviors in the Ctnnd2 knock out mouse model of autism spectrum disorders.
    Genes, brain, and behavior, 2023, Volume: 22, Issue:4

    Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Melatonin; Mice; Mice, Knockout; Sleep; Sleep

2023
Sleep disturbances in subjects with autism spectrum disorder: A parental perspective.
    Sleep medicine, 2023, Volume: 110

    Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Parents; Quality of Life; Retrospective Studies;

2023
Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort.
    Sleep medicine, 2023, Volume: 112

    Topics: Autism Spectrum Disorder; Child; Female; Humans; Male; Melatonin; Movement Disorders; Parasomnias; R

2023
Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder.
    Bratislavske lekarske listy, 2019, Volume: 120, Issue:11

    Topics: Adolescent; Autism Spectrum Disorder; Case-Control Studies; Child; Child, Preschool; Humans; Melaton

2019
Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Adolescent; Autism Spectrum Disorder; Biomarkers; Case-Control Studies; Caspase 7; Child; Child, Pre

2020
Melatonin for children with autism spectrum disorder.
    Canadian family physician Medecin de famille canadien, 2020, Volume: 66, Issue:3

    Topics: Autism Spectrum Disorder; Behavior Therapy; Child; Humans; Melatonin; Quality of Life; Sleep Initiat

2020
The bacterial neurometabolic signature of the gut microbiota of young children with autism spectrum disorders.
    Journal of medical microbiology, 2020, Volume: 69, Issue:4

    Topics: Autism Spectrum Disorder; Bacteria; Butyric Acid; Child, Preschool; Cohort Studies; Feces; Female; G

2020
Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder.
    Neurobiology of disease, 2020, Volume: 145

    Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Central Nervous System Depressants; Circadian R

2020
Melatonin dispensing among New Zealand children aged 0-18 years with autism: a nationwide cross-sectional study.
    Sleep medicine, 2021, Volume: 80

    Topics: Adolescent; Autism Spectrum Disorder; Autistic Disorder; Child; Child, Preschool; Cross-Sectional St

2021
Autism Spectrum Disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin.
    Medical hypotheses, 2021, Volume: 149

    Topics: Autism Spectrum Disorder; Circadian Rhythm; COVID-19; Disease Susceptibility; Genetic Variation; Hum

2021
Pediatric prolonged-release melatonin for insomnia in children and adolescents with autism spectrum disorders.
    Expert opinion on pharmacotherapy, 2021, Volume: 22, Issue:18

    Topics: Adolescent; Autism Spectrum Disorder; Child; Humans; Melatonin; Quality of Life; Sleep; Sleep Initia

2021
Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability.
    Journal of autism and developmental disorders, 2017, Volume: 47, Issue:7

    Topics: Adult; Anxiety; Autism Spectrum Disorder; Circadian Rhythm; Depression; Female; Humans; Male; Melato

2017
Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders.
    Scientific reports, 2017, 05-18, Volume: 7, Issue:1

    Topics: 14-3-3 Proteins; Acetylserotonin O-Methyltransferase; Adolescent; Adult; Arylalkylamine N-Acetyltran

2017
Heritability of the melatonin synthesis variability in autism spectrum disorders.
    Scientific reports, 2017, 12-18, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Arylalkylamine N-Acetyltransferase; Autism Spectrum Disorder; Child; Endophenotyp

2017
Low maternal melatonin level increases autism spectrum disorder risk in children.
    Research in developmental disabilities, 2018, Volume: 82

    Topics: Adult; Autism Spectrum Disorder; Case-Control Studies; Child; Female; Gene-Environment Interaction;

2018
Treating Children with ASD: The Perspective of Caregivers.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2018, Volume: 21, Issue:1s

    Topics: Adolescent; Autism Spectrum Disorder; Caregivers; Central Nervous System Depressants; Child; Female;

2018
Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism.
    Journal of autism and developmental disorders, 2020, Volume: 50, Issue:5

    Topics: Autism Spectrum Disorder; Autistic Disorder; Circadian Rhythm; Comorbidity; Databases, Genetic; Dopa

2020
Variations in Genes Related to Sleep Patterns in Children With Autism Spectrum Disorder.
    Biological research for nursing, 2019, Volume: 21, Issue:3

    Topics: Adolescent; Autism Spectrum Disorder; Child; Child, Preschool; Circadian Rhythm; Comorbidity; Female

2019
Melatonin for sleep problems in children with neurodevelopmental disorders.
    Drug and therapeutics bulletin, 2015, Volume: 53, Issue:10

    Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child; Humans; Hypnotics an

2015
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
    Molecular autism, 2016, Volume: 7

    Topics: Autism Spectrum Disorder; Biomarkers; Case-Control Studies; Child; Child, Preschool; Chromatography,

2016
Infant acetylcholine, dopamine, and melatonin dysregulation: Neonatal biomarkers and causal factors for ASD and ADHD phenotypes.
    Medical hypotheses, 2017, Volume: 100

    Topics: Acetylcholine; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Biomarkers;

2017
Characterizing Sleep in Adolescents and Adults with Autism Spectrum Disorders.
    Journal of autism and developmental disorders, 2017, Volume: 47, Issue:6

    Topics: Actigraphy; Adolescent; Adult; Autism Spectrum Disorder; Cross-Sectional Studies; Female; Humans; Hy

2017