melatonin has been researched along with Aura in 107 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "By adding melatonin, a decrease in the mean severity score of epilepsy (according to the Chalfont questionnaire) was 32." | 9.69 | Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial. ( Alyan NajafAbadi, S; Maghbooli, M; MalekMahmoudi, G; Molseghi, MH, 2023) |
| "Eleven prepubertal, developmentally normal children aged 6-11 years with epilepsy were randomized by a software algorithm to receive placebo or a 9-mg sustained release (SR) melatonin formulation for four weeks, followed by a one-week washout and a four-week crossover condition." | 9.20 | Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study. ( Beebe, DW; Byars, AW; Glauser, TA; Holland, K; Horn, PS; Jain, SV; Simakajornboon, N, 2015) |
| "In a double-blind, randomized, parallel-group, placebo-controlled trial, we assessed the effect of add-on melatonin (6-9 mg/day for 14 days) on the antioxidant enzymes glutathione peroxidase (GPx) and glutathione reductase (GRd) in 31 children with epilepsy receiving CBZ monotherapy, who were seizure free at least for the last 6 months." | 9.11 | Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. ( Agarwal, S; Aneja, S; Gupta, M; Gupta, YK; Kalaivani, M; Kohli, K, 2004) |
| "To assess the efficacy and tolerability of melatonin as add-on treatment for epilepsy." | 8.93 | Melatonin as add-on treatment for epilepsy. ( Brigo, F; Del Felice, A; Igwe, SC, 2016) |
| " It is not possible to draw any conclusion about the role of melatonin in reducing seizure frequency or improving quality of life in people with epilepsy." | 8.93 | Melatonin as add-on treatment for epilepsy. ( Brigo, F; Igwe, SC, 2016) |
| "There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy." | 8.91 | The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. ( Fusco, AD; Moyanova, S; Ngomba, RT; Tchekalarova, J, 2015) |
| " It is not possible to draw any conclusion about the role of melatonin in reducing seizure frequency or improving quality of life in patients with epilepsy." | 8.88 | Melatonin as add-on treatment for epilepsy. ( Brigo, F; Del Felice, A, 2012) |
| "This study examined melatonin (MLT) system in children with epilepsy." | 7.78 | Melatonin secretion in children with epilepsy. ( Dumalakiene, I; Jucaite, A; Kemezys, R; Mauricas, M; Praninskiene, R, 2012) |
| "A study on melatonin rhythm in children with generalized idiopathic epilepsy and simple fever is presented in this article." | 7.76 | Melatonin in epilepsy and febrile seizures. ( Andres, J; Ardura, F; Ardura, J; Garmendia, JR, 2010) |
| "The hypothesis may be formed that a lowered level of melatonin in the study group in relation to the comparison group is the consequence of the natural course of epilepsy or is influenced by antiepileptic drugs." | 7.76 | Melatonin and childhood refractory epilepsy--a pilot study. ( Dec, R; Jamroz, E; Marszał, E; Paprocka, J, 2010) |
| "Serum melatonin levels decreased in children with epilepsy or CFS." | 7.75 | [Serum melatonin levels in children with epilepsy or febrile seizures]. ( Guo, JF; Yao, BZ, 2009) |
| " This study was undertaken to investigate the effects of pinealectomy (Px) and melatonin treatments on the morphological changes in the liver tissue of newborn rats following experimental epilepsy during pregnancy." | 7.74 | Efficacy of melatonin on offspring liver maturation in pinealectomized pregnant rats subjected to experimental epilepsy. ( Ateş, U; Baka, M; Turgut, M; Uyanikgil, Y; Yavaşoğlu, A; Yurtseven, M, 2007) |
| "These findings suggest that epileptic seizures during pregnancy may cause an impaired hippocampal neurogenesis and neuronal maturation in the newborn, and the negative effects in the postnatal rat hippocampus are more dramatic after pinealectomy of the mother; conversely, melatonin administration suppresses these negative changes." | 7.73 | Pinealectomy stimulates and exogenous melatonin inhibits harmful effects of epileptiform activity during pregnancy in the hippocampus of newborn rats: an immunohistochemical study. ( Ateş, U; Baka, M; Turgut, M; Uyanikgil, Y; Yurtseven, ME, 2006) |
| "Diurnal seizures decreased significantly with melatonin compared with placebo (P = ." | 6.77 | Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. ( Garty, BZ; Goldberg-Stern, H; Oren, H; Peled, N, 2012) |
| "Melatonin has been advocated in treatment of sleep disorders, and its beneficial effect has been confirmed in insomnia." | 6.75 | Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010) |
| "Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime." | 6.71 | Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004) |
| "Epilepsy is thought to be associated with oxidative stress, glutamate excitotoxicity, and mitochondrial dysfunction." | 6.53 | Glutamate Excitotoxicity and Oxidative Stress in Epilepsy: Modulatory Role of Melatonin. ( Parvez, S; Raisuddin, S; Vishnoi, S, 2016) |
| "In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy." | 6.47 | Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 5.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "By adding melatonin, a decrease in the mean severity score of epilepsy (according to the Chalfont questionnaire) was 32." | 5.69 | Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial. ( Alyan NajafAbadi, S; Maghbooli, M; MalekMahmoudi, G; Molseghi, MH, 2023) |
| "Epilepsy is a chronic neurological disease with recurrent seizures." | 5.62 | Melatonin and Epilepsy. ( Vasileva, Z, 2021) |
| "in patients with diurnal seizures (occurring mainly in the morning) may suggest proconvulsive effect of this hormone." | 5.40 | Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report. ( Czuczwar, SJ; Gołba, A; Motta, E; Norman, R; Ostrowska, Z; Sołtyk, J; Woźnik, G, 2014) |
| "Epilepsy is the most common neurological disorder, approximately 1% of the population worldwide have epilepsy." | 5.35 | Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis. ( Amado, D; Arida, RM; Cavalheiro, EA; Colugnati, DB; de Lima, E; Naffah-Mazzacoratti, Mda G; Scorza, FA, 2008) |
| "Melatonin was reduced in patients with epilepsy at baseline compared with controls, and increased threefold following seizures." | 5.31 | Patients with intractable epilepsy have low melatonin, which increases following seizures. ( Bazil, CW; Crispin, D; Short, D; Zheng, W, 2000) |
| "Eleven prepubertal, developmentally normal children aged 6-11 years with epilepsy were randomized by a software algorithm to receive placebo or a 9-mg sustained release (SR) melatonin formulation for four weeks, followed by a one-week washout and a four-week crossover condition." | 5.20 | Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study. ( Beebe, DW; Byars, AW; Glauser, TA; Holland, K; Horn, PS; Jain, SV; Simakajornboon, N, 2015) |
| "We conclude that melatonin does not alter the quality of sleep EEG studies in children with epilepsy or suspected epilepsy." | 5.16 | Melatonin does not influence sleep deprivation electroencephalogram recordings in children. ( Gortner, L; Gottschling, S; Gräber, S; Meyer, S; Sander, J; Shamdeen, MG, 2012) |
| "In a double-blind, randomized, parallel-group, placebo-controlled trial, we assessed the effect of add-on melatonin (6-9 mg/day for 14 days) on the antioxidant enzymes glutathione peroxidase (GPx) and glutathione reductase (GRd) in 31 children with epilepsy receiving CBZ monotherapy, who were seizure free at least for the last 6 months." | 5.11 | Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. ( Agarwal, S; Aneja, S; Gupta, M; Gupta, YK; Kalaivani, M; Kohli, K, 2004) |
| "To assess the efficacy and tolerability of melatonin as add-on treatment for epilepsy." | 4.93 | Melatonin as add-on treatment for epilepsy. ( Brigo, F; Del Felice, A; Igwe, SC, 2016) |
| " It is not possible to draw any conclusion about the role of melatonin in reducing seizure frequency or improving quality of life in people with epilepsy." | 4.93 | Melatonin as add-on treatment for epilepsy. ( Brigo, F; Igwe, SC, 2016) |
| "There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy." | 4.91 | The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. ( Fusco, AD; Moyanova, S; Ngomba, RT; Tchekalarova, J, 2015) |
| "Melatonin is widely used for sleep disorders in patients with a range of developmental disorders and neurodisabilities, who also frequently have epilepsy." | 4.89 | Does melatonin affect epileptic seizures? ( Besag, FM; Jain, S, 2013) |
| " It is not possible to draw any conclusion about the role of melatonin in reducing seizure frequency or improving quality of life in patients with epilepsy." | 4.88 | Melatonin as add-on treatment for epilepsy. ( Brigo, F; Del Felice, A, 2012) |
| " This article focuses on the following specific neurologic diseases: nocturnal frontal lobe epilepsy and abnormal motor behaviors of epileptic origin, evaluating differential diagnosis with parasomnias; achondroplasia, confirming the crucial role of craniofacial deformity in determining sleep-disordered breathing; neuromuscular diseases, mainly Duchenne's muscular dystrophy and myotonic dystrophy; cerebral palsy, evaluating either the features of sleep architecture and the importance of the respiratory problems associated; headaches, confirming the strict relationships with sleep in terms of neurochemical and neurobehavioral substrates; and finally a review on the effectiveness of melatonin for sleep problems in children with neurologic syndromes and mental retardation, blindness, and epilepsy." | 4.81 | Sleep disorders in children with neurologic diseases. ( Bruni, O; Zucconi, M, 2001) |
| " In our experience we gave melatonin to a girl with severe myoclonic epilepsy which did not respond to usual treatment, obtaining improvement in both the number of crises daily and in psycho-motor development." | 4.79 | [The effect of melatonin as anti-convulsant and neuron protector]. ( Acuña-Castroviejo, D; Molina-Carballo, A; Molina-Font, JA; Moreno-Madrid, F; Muñoz-Hoyos, A; Sánchez-Forte, M, 1997) |
| "Studies about the relationship between epileptic seizures (ESs) and melatonin are limited in children and have been performed in heterogeneous patient groups and with different methods." | 3.96 | The relationship between epileptic seizure and melatonin in children. ( Aksu Uzunhan, T; Kacar, A; Kucur, M; Saltik, S; Tarcin, G, 2020) |
| "Levels of melatonin have been reported before in children with epilepsy, but such has not been reported to date in those with continuous spikes and waves during sleep." | 3.91 | Levels of Melatonin in Continuous Spikes and Waves During Sleep. ( Aksoy, HU; Ayça, S; Polat, M; Taştan, İ, 2019) |
| "This study examined melatonin (MLT) system in children with epilepsy." | 3.78 | Melatonin secretion in children with epilepsy. ( Dumalakiene, I; Jucaite, A; Kemezys, R; Mauricas, M; Praninskiene, R, 2012) |
| "The hypothesis may be formed that a lowered level of melatonin in the study group in relation to the comparison group is the consequence of the natural course of epilepsy or is influenced by antiepileptic drugs." | 3.76 | Melatonin and childhood refractory epilepsy--a pilot study. ( Dec, R; Jamroz, E; Marszał, E; Paprocka, J, 2010) |
| "A study on melatonin rhythm in children with generalized idiopathic epilepsy and simple fever is presented in this article." | 3.76 | Melatonin in epilepsy and febrile seizures. ( Andres, J; Ardura, F; Ardura, J; Garmendia, JR, 2010) |
| "Serum melatonin levels decreased in children with epilepsy or CFS." | 3.75 | [Serum melatonin levels in children with epilepsy or febrile seizures]. ( Guo, JF; Yao, BZ, 2009) |
| " This study was undertaken to investigate the effects of pinealectomy (Px) and melatonin treatments on the morphological changes in the liver tissue of newborn rats following experimental epilepsy during pregnancy." | 3.74 | Efficacy of melatonin on offspring liver maturation in pinealectomized pregnant rats subjected to experimental epilepsy. ( Ateş, U; Baka, M; Turgut, M; Uyanikgil, Y; Yavaşoğlu, A; Yurtseven, M, 2007) |
| "These findings suggest that epileptic seizures during pregnancy may cause an impaired hippocampal neurogenesis and neuronal maturation in the newborn, and the negative effects in the postnatal rat hippocampus are more dramatic after pinealectomy of the mother; conversely, melatonin administration suppresses these negative changes." | 3.73 | Pinealectomy stimulates and exogenous melatonin inhibits harmful effects of epileptiform activity during pregnancy in the hippocampus of newborn rats: an immunohistochemical study. ( Ateş, U; Baka, M; Turgut, M; Uyanikgil, Y; Yurtseven, ME, 2006) |
| " The results support the hypothesis that suppression of the nocturnal concentrations of the endogenous anticonvulsant melatonin by sudden increases in geomagnetic activity may encourage fatal cardiac arrhythmias by uncoupling the insular/amygdaloid-paraventricular hypothalamic-solitary nucleus pathways." | 3.69 | Sudden unexpected death in epileptics following sudden, intense, increases in geomagnetic activity: prevalence of effect and potential mechanisms. ( Persinger, MA; Psych, C, 1995) |
| "The daily rhythms of melatonin, cortisol and body temperature were studied in 16 institutionalized subjects with the Lennox-Gastaut syndrome." | 3.68 | Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders. ( Alila, A; Hätönen, T; Heiskala, H; Laakso, ML; Leinonen, L, 1993) |
| "Roles for melatonin, taurine, and the pineal gland in epilepsy are examined." | 3.67 | Could supplementary dietary tryptophan and taurine prevent epileptic seizures? ( Maurizi, CP, 1985) |
| "In 66 patients with some diseases of the nervous system (epilepsy, brain tumors, traumatic brain lesions, discorgenic lumbosacral radiculitis) melatonin content in liquor was determined by a fluorimetric method, especially modified for this purpose." | 3.65 | [Cerebrospinal fluid melatonin in diseases of the nervous system]. ( Kiselev, VN; Loboda, EB; Makarov, AIu, 1977) |
| "Diurnal seizures decreased significantly with melatonin compared with placebo (P = ." | 2.77 | Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. ( Garty, BZ; Goldberg-Stern, H; Oren, H; Peled, N, 2012) |
| "Melatonin has been advocated in treatment of sleep disorders, and its beneficial effect has been confirmed in insomnia." | 2.75 | Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010) |
| "Melatonin has been shown to be an antioxidant, antiexcitotoxic, and anti-inflammatory hormone/molecule in neurodegenerative diseases, which may contribute to its antiepileptic and neuroprotective properties in epilepsy as well." | 2.72 | Melatonin as an Antiepileptic Molecule: Therapeutic Implications via Neuroprotective and Inflammatory Mechanisms. ( Akyuz, E; Arulsamy, A; Kullu, I; Shaikh, MF, 2021) |
| "Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime." | 2.71 | Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004) |
| "Sleep deprivation is a common trigger of seizures in many persons with epilepsy and sleep patterns play a role in the occurrence of seizures." | 2.58 | Neuroendocrine aspects of improving sleep in epilepsy. ( Chuang, SH; Crepeau, AZ; Hunn, D; Maganti, R; Reddy, DS, 2018) |
| "Epilepsy is thought to be associated with oxidative stress, glutamate excitotoxicity, and mitochondrial dysfunction." | 2.53 | Glutamate Excitotoxicity and Oxidative Stress in Epilepsy: Modulatory Role of Melatonin. ( Parvez, S; Raisuddin, S; Vishnoi, S, 2016) |
| "Melatonin is a hormone produced by the pineal gland during the night in response to light/dark information received by the retina and its integration by the suprachiasmatic nucleus." | 2.52 | Potential safety issues in the use of the hormone melatonin in paediatrics. ( Kennaway, DJ, 2015) |
| "Pediatric insomnia is an extrinsic sleep disorder subdivided into two categories: behavioral insomnia and insomnia related to medical, neurological, and psychiatric diseases." | 2.50 | Pediatric insomnia: clinical, diagnosis, and treatment. ( Miano, S; Peraita-Adrados, R, 2014) |
| "In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy." | 2.47 | Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011) |
| "More studies on the prevalence of other sleep disorders in people with epilepsy and the effect of treatment are required." | 2.47 | Sleep disturbances in people with epilepsy; prevalence, impact and treatment. ( de Weerd, AW; Gutter, T; van Golde, EG, 2011) |
| "Caregivers usually report that insomnia is the most frequent sleep disorder, described as disorders of initiating and maintaining sleep, restless sleep, bedtime resistance, co-sleeping, alterations of sleep hygiene, and early awakenings in the morning." | 2.46 | Epidemiology and management of insomnia in children with autistic spectrum disorders. ( Ferri, R; Miano, S, 2010) |
| " However, in selected cases, depending on the effectiveness of the interventions, dosage reductions or discontinuation of medications may be possible." | 2.44 | Natural approaches to epilepsy. ( Gaby, AR, 2007) |
| "These include sleep disorders with a specific relationship to epilepsy, the influences of sleep and sleep deprivation on interictal epileptiform discharges, detrimental effects of seizures on sleep, and the effects (good and bad) of epilepsy treatments on sleep." | 2.42 | Sleep-related epilepsy. ( Bazil, CW, 2003) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 1.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Melatonin has been used in clinical anti-epileptic studies, but its effect on epileptic comorbidities is unknown, and the underlying mechanism needs further investigation." | 1.62 | Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. ( Gao, D; Jin, M; Li, N; Liu, K; Mou, L; Ren, Q; Sik, A; Zhang, M; Zhang, S, 2021) |
| "Epilepsy is a chronic neurological disease with recurrent seizures." | 1.62 | Melatonin and Epilepsy. ( Vasileva, Z, 2021) |
| "Melatonin is an indolic hormone that regulates a plethora of functions ranging from the regulation of circadian rhythms and antioxidant properties to the induction and maintenance of tumor suppressor pathways." | 1.46 | Melatonin and Hippo Pathway: Is There Existing Cross-Talk? ( Blandino, G; Lo Sardo, F; Muti, P; Strano, S, 2017) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| "Melatonin and sleep deprivation were equally efficient in inducing sleep (70% in both groups)." | 1.42 | Occurrence of epileptiform discharges and sleep during EEG recordings in children after melatonin intake versus sleep-deprivation. ( Broström, A; Gustafsson, G; Svanborg, E; Ulander, M; Vrethem, M, 2015) |
| "in patients with diurnal seizures (occurring mainly in the morning) may suggest proconvulsive effect of this hormone." | 1.40 | Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report. ( Czuczwar, SJ; Gołba, A; Motta, E; Norman, R; Ostrowska, Z; Sołtyk, J; Woźnik, G, 2014) |
| "Epilepsy is a chronic neurologic disorder which often induces numerous adverse long-term neurologic effects, such as behavioral and cognitive deficits, increased predisposition to additional seizures, and cell injury or death." | 1.40 | Therapeutic potential of agomelatine in epilepsy and epileptic complications. ( Bhutada, PS; Patel, FR; Vimala, PV, 2014) |
| "Although melatonin influences seizure thresholds, the relationship is complex." | 1.37 | Light therapy as a treatment for epilepsy. ( Baxendale, SA, 2011) |
| "Epilepsy is the most common neurological disorder, approximately 1% of the population worldwide have epilepsy." | 1.35 | Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis. ( Amado, D; Arida, RM; Cavalheiro, EA; Colugnati, DB; de Lima, E; Naffah-Mazzacoratti, Mda G; Scorza, FA, 2008) |
| "Their epilepsy was early onset, and different anticonvulsive treatments have been administered for them for many years, ineffectively." | 1.32 | [Effect of melatonin on intractable epilepsies]. ( Rosdy, B; Saracz, J, 2004) |
| "Melatonin was reduced in patients with epilepsy at baseline compared with controls, and increased threefold following seizures." | 1.31 | Patients with intractable epilepsy have low melatonin, which increases following seizures. ( Bazil, CW; Crispin, D; Short, D; Zheng, W, 2000) |
| "During the seizure-free interval, the circadian profile of serum prolactin was lower in female patients than in healthy women." | 1.28 | Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels. ( Bauer, J; Rao, ML; Stefan, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (9.35) | 18.7374 |
| 1990's | 15 (14.02) | 18.2507 |
| 2000's | 36 (33.64) | 29.6817 |
| 2010's | 36 (33.64) | 24.3611 |
| 2020's | 10 (9.35) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Ren, Q | 1 |
| Gao, D | 1 |
| Mou, L | 1 |
| Zhang, S | 1 |
| Zhang, M | 1 |
| Li, N | 1 |
| Sik, A | 1 |
| Jin, M | 1 |
| Liu, K | 1 |
| Hosseinzadeh, A | 1 |
| Dehdashtian, E | 1 |
| Jafari-Sabet, M | 1 |
| Mehrzadi, S | 1 |
| Vasileva, Z | 1 |
| Maghbooli, M | 1 |
| Alyan NajafAbadi, S | 1 |
| MalekMahmoudi, G | 1 |
| Molseghi, MH | 1 |
| Bonuccelli, A | 1 |
| Santangelo, A | 1 |
| Castelli, F | 1 |
| Magherini, G | 1 |
| Volpi, E | 1 |
| Costa, E | 1 |
| Alesci, E | 1 |
| Massimetti, G | 1 |
| Operto, FF | 1 |
| Peroni, DG | 1 |
| Orsini, A | 1 |
| Li, P | 1 |
| Ji, X | 1 |
| Shan, M | 1 |
| Wang, Y | 1 |
| Dai, X | 1 |
| Yin, M | 1 |
| Liu, Y | 1 |
| Guan, L | 1 |
| Ye, L | 1 |
| Cheng, H | 1 |
| Tarcin, G | 2 |
| Aksu Uzunhan, T | 1 |
| Kacar, A | 1 |
| Kucur, M | 1 |
| Saltik, S | 1 |
| Kennaway, DJ | 2 |
| Akyuz, E | 1 |
| Kullu, I | 1 |
| Arulsamy, A | 1 |
| Shaikh, MF | 1 |
| Lo Sardo, F | 1 |
| Muti, P | 1 |
| Blandino, G | 1 |
| Strano, S | 1 |
| Reddy, DS | 1 |
| Chuang, SH | 1 |
| Hunn, D | 1 |
| Crepeau, AZ | 1 |
| Maganti, R | 1 |
| Ayça, S | 1 |
| Aksoy, HU | 1 |
| Taştan, İ | 1 |
| Polat, M | 1 |
| Albrecht, M | 1 |
| Zitta, K | 1 |
| Groenendaal, F | 1 |
| van Bel, F | 1 |
| Peeters-Scholte, C | 1 |
| Ramgopal, S | 1 |
| Thome-Souza, S | 1 |
| Loddenkemper, T | 1 |
| Jain, S | 1 |
| Besag, FM | 1 |
| Banerjee, S | 1 |
| Kumar, V | 1 |
| Mori, K | 1 |
| Vimala, PV | 1 |
| Bhutada, PS | 1 |
| Patel, FR | 1 |
| Mareš, J | 1 |
| Stopka, P | 1 |
| Nohejlová, K | 1 |
| Rokyta, R | 1 |
| Miano, S | 2 |
| Peraita-Adrados, R | 1 |
| Motta, E | 1 |
| Czuczwar, SJ | 1 |
| Ostrowska, Z | 1 |
| Gołba, A | 1 |
| Sołtyk, J | 1 |
| Norman, R | 1 |
| Woźnik, G | 1 |
| Gustafsson, G | 1 |
| Broström, A | 1 |
| Ulander, M | 1 |
| Vrethem, M | 1 |
| Svanborg, E | 1 |
| Jain, SV | 1 |
| Horn, PS | 1 |
| Simakajornboon, N | 1 |
| Beebe, DW | 1 |
| Holland, K | 1 |
| Byars, AW | 1 |
| Glauser, TA | 1 |
| Manni, R | 1 |
| Cremascoli, R | 1 |
| De Icco, R | 1 |
| Terzaghi, M | 1 |
| Zisapel, N | 1 |
| Tchekalarova, J | 1 |
| Moyanova, S | 1 |
| Fusco, AD | 1 |
| Ngomba, RT | 1 |
| Brigo, F | 3 |
| Igwe, SC | 2 |
| Del Felice, A | 2 |
| Vishnoi, S | 1 |
| Raisuddin, S | 1 |
| Parvez, S | 1 |
| Ma, Y | 1 |
| Sun, X | 1 |
| Li, J | 1 |
| Jia, R | 1 |
| Yuan, F | 1 |
| Wei, D | 1 |
| Jiang, W | 1 |
| Avakian, GN | 1 |
| Denisova, SV | 1 |
| Oleĭnikova, OM | 1 |
| Kurbanova, SA | 1 |
| Solmaz, I | 1 |
| Gürkanlar, D | 1 |
| Gökçil, Z | 1 |
| Göksoy, C | 1 |
| Ozkan, M | 1 |
| Erdoğan, E | 1 |
| Guo, JF | 1 |
| Yao, BZ | 1 |
| Hofstra, WA | 1 |
| de Weerd, AW | 2 |
| Ashrafi, MR | 1 |
| Mohammadi, M | 1 |
| Tafarroji, J | 1 |
| Shabanian, R | 1 |
| Salamati, P | 1 |
| Zamani, GR | 1 |
| Kuzniecky, RI | 1 |
| Ferri, R | 1 |
| Elkhayat, HA | 1 |
| Hassanein, SM | 1 |
| Tomoum, HY | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Efficacy of Melatony Versus Sleep Deprivation for EEG Recordings in Sleep: a Randomized Crossed-over Study in Pediatric Patients With Epilepsy[NCT05654415] | 30 participants (Anticipated) | Interventional | 2021-09-01 | Active, not recruiting | |||
| Effect of Melatonin Supplementation on Sleep and Health of Children With Cerebral Palsy[NCT04392063] | 40 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| Prevalence of Epilepsy and Sleep Wake Disorders in Alzheimer Disease[NCT03617497] | 78 participants (Actual) | Interventional | 2020-12-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
32 reviews available for melatonin and Aura
| Article | Year |
|---|---|
Melatonin as an Antiepileptic Molecule: Therapeutic Implications via Neuroprotective and Inflammatory Mechanisms.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Epilepsy; Humans; Melatonin; Seizures | 2021 |
Neuroendocrine aspects of improving sleep in epilepsy.
Topics: Animals; Circadian Rhythm; Epilepsy; Humans; Melatonin; Neurosecretory Systems; Receptors, GABA; Sle | 2018 |
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.
Topics: Allopurinol; Asphyxia Neonatorum; Biotin; Cerebral Palsy; Clinical Trials as Topic; Epilepsy; Erythr | 2019 |
Chronopharmacology of anti-convulsive therapy.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Anticonvulsants; Biotransformation; Body Temperature; C | 2013 |
Does melatonin affect epileptic seizures?
Topics: Central Nervous System Depressants; Developmental Disabilities; Epilepsy; Humans; Melatonin; Randomi | 2013 |
[Psychopharmacological interventions in autism spectrum disorders].
Topics: Child; Child Development Disorders, Pervasive; Dopamine; Epilepsy; gamma-Aminobutyric Acid; Humans; | 2010 |
Pediatric insomnia: clinical, diagnosis, and treatment.
Topics: Adolescent; Behavior Therapy; Child; Child Behavior Disorders; Chronobiology Disorders; Cognition Di | 2014 |
Potential safety issues in the use of the hormone melatonin in paediatrics.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Melatonin; Patient Safety; Sleep; Sle | 2015 |
The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders.
Topics: Animals; Comorbidity; Epilepsy; Humans; Melatonin; Mental Disorders | 2015 |
Melatonin as add-on treatment for epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Hu | 2016 |
Melatonin as add-on treatment for epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Hu | 2016 |
Glutamate Excitotoxicity and Oxidative Stress in Epilepsy: Modulatory Role of Melatonin.
Topics: Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Melatonin; Neurotoxins; Oxidativ | 2016 |
[A role of circadian factors and melatonin in the development of epileptic paroxysms].
Topics: Brain; Circadian Rhythm; Disease Progression; Epilepsy; Humans; Melatonin; Prognosis | 2007 |
The circadian rhythm and its interaction with human epilepsy: a review of literature.
Topics: Adult; Animals; Biological Clocks; Body Temperature Regulation; Brain; Child; Circadian Rhythm; CLOC | 2009 |
Epidemiology and management of insomnia in children with autistic spectrum disorders.
Topics: Age Factors; Autistic Disorder; Behavior Therapy; Child; Electroencephalography; Epilepsy; Humans; H | 2010 |
Sleep disturbances in people with epilepsy; prevalence, impact and treatment.
Topics: Adolescent; Adult; Central Nervous System Depressants; Child; Epilepsy; Female; Humans; Male; Melato | 2011 |
Melatonin in experimental seizures and epilepsy.
Topics: Animals; Anticonvulsants; Antioxidants; Child; Disease Models, Animal; Epilepsy; Humans; Melatonin; | 2011 |
Melatonin as add-on treatment for epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Hu | 2012 |
[Melatonin and epilepsy].
Topics: Anticonvulsants; Circadian Rhythm; Electroencephalography; Epilepsy; Humans; Light; Melatonin; Neuro | 2002 |
Sleep-related epilepsy.
Topics: Anticonvulsants; Electric Stimulation Therapy; Electroencephalography; Epilepsy; Humans; Melatonin; | 2003 |
Sleep disorders, epilepsy, and autism.
Topics: Antioxidants; Autistic Disorder; Child; Circadian Rhythm; Epilepsy; Humans; Melatonin; Polysomnograp | 2004 |
Sleep and childhood epilepsy.
Topics: Anticonvulsants; Child; Cognition; Electroencephalography; Epilepsy; Humans; Melatonin; Sleep; Sleep | 2005 |
Alternative approaches to conventional antiepileptic drugs in the management of paediatric epilepsy.
Topics: Adrenal Cortex Hormones; Alcohol Drinking; Child; Child, Preschool; Complementary Therapies; Diet; E | 2006 |
[Disruptions of circadian rhythm in neurologic disorders].
Topics: Autonomic Nervous System Diseases; Body Temperature Regulation; Brain Neoplasms; Central Nervous Sys | 2006 |
Natural approaches to epilepsy.
Topics: Biotin; Carnitine; Diet; Dietary Supplements; Epilepsy; Fatty Acids, Essential; Folic Acid; Humans; | 2007 |
[Hormones and epileptic activity].
Topics: Adrenal Cortex Hormones; Animals; Anticonvulsants; Brain; Child; Combined Modality Therapy; Endocrin | 1984 |
[The effect of melatonin as anti-convulsant and neuron protector].
Topics: Animals; Epilepsy; Female; Humans; Melatonin; Rats | 1997 |
The therapeutics of melatonin: a paediatric perspective.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Melatonin; Sleep Wake Disorders | 2000 |
Endogenous melatonin and epileptogenesis: facts and hypothesis.
Topics: Brain; Circadian Rhythm; Dopamine; Down-Regulation; Epilepsy; Humans; Melatonin | 2001 |
Sleep disorders in children with neurologic diseases.
Topics: Anticonvulsants; Blindness; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Headache; Hu | 2001 |
The pineal gland: a review of the biochemistry, physiology and pharmacological potential of melatonin and other pineal substances.
Topics: Animals; Brain; Brain Diseases; Brain Neoplasms; Calcinosis; Circadian Rhythm; Endocrine Glands; Epi | 1977 |
Melatonin: effects on brain function.
Topics: Adenylyl Cyclases; Aminobutyrates; Animals; Behavior; Brain; Cerebral Cortex; Cyclic AMP; Electric S | 1974 |
13 trials available for melatonin and Aura
| Article | Year |
|---|---|
Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Anticonvulsants; Cross-Sectional Studies; Epilepsy; Humans; Melatonin; Seizures; Sleep Qualit | 2023 |
Efficacy of Liposomal Melatonin in sleep EEG in Childhood: A Double Blind Case Control Study.
Topics: Case-Control Studies; Child; Child, Preschool; Double-Blind Method; Electroencephalography; Epilepsy | 2022 |
Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study.
Topics: Child; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Electroencephalography; | 2015 |
Melatonin and sleep-related problems in children with intractable epilepsy.
Topics: Adolescent; Bruxism; Child; Child, Preschool; Epilepsy; Female; Humans; Hypnotics and Sedatives; Mal | 2010 |
Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy.
Topics: Child; Child, Preschool; Epilepsy; Humans; Melatonin; Placebos; Sleep Wake Disorders; Treatment Outc | 2011 |
Melatonin does not influence sleep deprivation electroencephalogram recordings in children.
Topics: Adolescent; Central Nervous System Depressants; Child, Preschool; Electroencephalography; Epilepsy; | 2012 |
Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study.
Topics: Actigraphy; Adolescent; Adult; Antioxidants; Child; Cross-Over Studies; Epilepsy; Female; Humans; Ma | 2012 |
Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Cross-Over Studies; Dose-Response Relationsh | 2004 |
Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Cros | 2004 |
A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes.
Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combinati | 2004 |
Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Antioxidants; Carbamazepine; Child; Child, Preschool; Double-Blind Method; Drug Int | 2004 |
Melatonin effect on seizures in children with severe neurologic deficit disorders.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Antioxidants; Child; Child, Preschool; Drug Admin | 2001 |
Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study.
Topics: Adolescent; Child; Child, Preschool; Developmental Disabilities; Dose-Response Relationship, Drug; E | 2002 |
62 other studies available for melatonin and Aura
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy; Gene | 2021 |
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice.
Topics: Animals; Anticonvulsants; Cholecalciferol; Disease Models, Animal; Epilepsy; Melatonin; Mice; Pentyl | 2022 |
Melatonin and Epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Epilepsy; Humans; Melatonin; Seizures | 2021 |
Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy.
Topics: Animals; Epilepsy; Lipopolysaccharides; Melatonin; Mice; Microglia; Signal Transduction | 2023 |
The relationship between epileptic seizure and melatonin in children.
Topics: Child; Electroencephalography; Epilepsy; Humans; Melatonin; Seizures; Status Epilepticus | 2020 |
Response to Dr. Kennaway.
Topics: Child; Epilepsy; Humans; Melatonin; Seizures | 2021 |
Melatonin measurement in epilepsy; are the assays letting us down?
Topics: Child; Epilepsy; Humans; Melatonin; Seizures | 2021 |
Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
Topics: Animals; Antioxidants; Circadian Rhythm; Epilepsy; Humans; Melatonin; Protein Serine-Threonine Kinas | 2017 |
Levels of Melatonin in Continuous Spikes and Waves During Sleep.
Topics: Child; Circadian Rhythm; Electroencephalography; Epilepsy; Female; Humans; Male; Melatonin; Sleep | 2019 |
Question 1: in a child with epilepsy, does melatonin affect the seizure threshold?
Topics: Child; Epilepsy; Humans; Melatonin; Sleep Wake Disorders | 2013 |
Therapeutic potential of agomelatine in epilepsy and epileptic complications.
Topics: Acetamides; Antidepressive Agents; Cell Survival; Circadian Rhythm; Drug Discovery; Epilepsy; Hippoc | 2014 |
Oxidative stress induced by epileptic seizure and its attenuation by melatonin.
Topics: Animals; Antioxidants; Central Nervous System Depressants; Epilepsy; Hydroxyl Radical; Male; Melaton | 2013 |
Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report.
Topics: Adult; Circadian Rhythm; Epilepsy; Female; Humans; Male; Melatonin; Middle Aged; Saliva; Seizures; Y | 2014 |
Occurrence of epileptiform discharges and sleep during EEG recordings in children after melatonin intake versus sleep-deprivation.
Topics: Adolescent; Brain; Central Nervous System Depressants; Child; Child, Preschool; Electroencephalograp | 2015 |
Chronotype in patients with epilepsy: A controlled study in 60 subjects with late-onset focal epilepsy.
Topics: Adult; Case-Control Studies; Circadian Rhythm; Epilepsy; Female; Humans; Male; Melatonin; Middle Age | 2015 |
Safety of melatonin.
Topics: Epilepsy; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2015 |
Melatonin Alleviates the Epilepsy-Associated Impairments in Hippocampal LTP and Spatial Learning Through Rescue of Surface GluR2 Expression at Hippocampal CA1 Synapses.
Topics: Animals; Antioxidants; CA1 Region, Hippocampal; Epilepsy; Long-Term Potentiation; Male; Melatonin; R | 2017 |
Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Convulsants; Disease Models, An | 2009 |
[Serum melatonin levels in children with epilepsy or febrile seizures].
Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Melatonin; Seizures, Febrile | 2009 |
Melatonin versus chloral hydrate for recording sleep EEG.
Topics: Child; Child, Preschool; Chloral Hydrate; Electroencephalography; Epilepsy; Female; Humans; Hypnotic | 2010 |
Report from the 2004 AES Annual Meeting. Highlights from the 58th Annual Meeting of the American Epilepsy Society, December 3-7, 2004, New Orleans, LA.
Topics: Animals; Aromatase Inhibitors; Complementary Therapies; Disease Models, Animal; Epilepsy; Gonadal St | 2005 |
Melatonin in epilepsy and febrile seizures.
Topics: Analysis of Variance; Case-Control Studies; Child; Child, Preschool; Circadian Rhythm; Data Interpre | 2010 |
Melatonin and childhood refractory epilepsy--a pilot study.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Epilepsy, Gen | 2010 |
Light therapy as a treatment for epilepsy.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Humans; Light; Melatonin; Models, Biological; Mo | 2011 |
Melatonin secretion in children with epilepsy.
Topics: Adolescent; Analysis of Variance; Area Under Curve; Child; Circadian Rhythm; Enzyme-Linked Immunosor | 2012 |
Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Topics: Animals; Brain; Cell Death; DNA Damage; DNA, Mitochondrial; Dose-Response Relationship, Drug; Drug I | 2003 |
Pineal cysts in childhood.
Topics: Adolescent; alpha-Fetoproteins; Bradycardia; Child; Child, Preschool; Chorionic Gonadotropin, beta S | 2003 |
Diurnal actions of melatonin on epileptic activity in hippocampal slices of rats.
Topics: Animals; Bicuculline; Circadian Rhythm; Electroencephalography; Epilepsy; GABA Antagonists; Hippocam | 2003 |
Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Dis | 2004 |
Evidence based medicine.
Topics: Adaptation, Psychological; Capital Financing; Cerebral Palsy; Child; Epilepsy; Evidence-Based Medici | 2004 |
[Effect of melatonin on intractable epilepsies].
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Drug Resistance; Drug Therapy, Combination; Electro | 2004 |
Beneficial effects of melatonin on morphological changes in postnatal cerebellar tissue owing to epileptiform activity during pregnancy in rats: light and immunohistochemical study.
Topics: Animals; Cerebellum; Epilepsy; Female; Immunohistochemistry; Intermediate Filament Proteins; Melaton | 2005 |
Melatonin and epilepsy.
Topics: Adolescent; Adult; Child; Epilepsy; Humans; Melatonin; Retrospective Studies; Sleep Wake Disorders | 2005 |
Pinealectomy stimulates and exogenous melatonin inhibits harmful effects of epileptiform activity during pregnancy in the hippocampus of newborn rats: an immunohistochemical study.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Epilepsy; Female; Gene Expression | 2006 |
Anticonvulsant effects of melatonin on penicillin-induced epileptiform activity in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Resp | 2006 |
Efficacy of melatonin on offspring liver maturation in pinealectomized pregnant rats subjected to experimental epilepsy.
Topics: Animals; Epilepsy; Female; In Situ Nick-End Labeling; Liver; Melatonin; Pineal Gland; Pregnancy; Pre | 2007 |
Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis.
Topics: Cardiotonic Agents; Death, Sudden; Epilepsy; Humans; Melatonin; Models, Biological; Risk Factors; Se | 2008 |
[The pineal gland and epilepsy].
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Melatonin; Pineal Gland | 1982 |
Sudden unexpected death in epileptics following sudden, intense, increases in geomagnetic activity: prevalence of effect and potential mechanisms.
Topics: Animals; Arrhythmias, Cardiac; Death, Sudden; Electromagnetic Phenomena; Epilepsy; Geography; Humans | 1995 |
Day-night variations in melatonin secretion by the pineal gland during febrile and epileptic convulsions in children.
Topics: Brain; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infant; Male; Melatonin; | 1994 |
Melatonin response in active epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Male; Melato | 1995 |
Effects of febrile and epileptic convulsions on daily variations in plasma melatonin concentration in children.
Topics: Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infant; Male; Melatonin; Radioi | 1994 |
[Diurnal secretion profile of melatonin in epileptic children with or without photosensitivity and an observation of altered circadian rhythm in a case of completely under dark living condition].
Topics: Child; Child, Preschool; Circadian Rhythm; Dark Adaptation; Electroencephalography; Epilepsy; Female | 1993 |
Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders.
Topics: Adolescent; Adult; Axilla; Body Temperature Regulation; Child; Circadian Rhythm; Epilepsy; Female; H | 1993 |
Geophysical variables and behavior: LXXIX. Overt limbic seizures are associated with concurrent and premidscotophase geomagnetic activity: synchronization by prenocturnal feeding.
Topics: Amygdala; Animals; Arousal; Circadian Rhythm; Corticotropin-Releasing Hormone; Electroencephalograph | 1995 |
Melatonin reduces low-Mg2+ epileptiform activity in human temporal slices.
Topics: Autoradiography; Electrophysiology; Epilepsy; Humans; In Vitro Techniques; Iodine Radioisotopes; Mag | 1995 |
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infa | 1997 |
Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Azepines; Brain Chemistry; Disease Models, Animal; D | 1998 |
Persistent elevation of nocturnal activity in rodents following apparent recovery from lithium/pilocarpine-induced limbic seizures.
Topics: Animals; Behavior, Animal; Brain; Circadian Rhythm; Epilepsy; Limbic System; Lithium; Male; Melatoni | 1998 |
Anticonvulsant effects of melatonin in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Circadian Rhythm; Disease Models, Animal; Dose-Response Relation | 1998 |
Re: Sadler's article regarding lamotrigine-associated insomnia in an adult tertiary care epilepsy out-patient clinic.
Topics: Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Lamotrigine; Melatonin; Sleep Initiation an | 2000 |
Patients with intractable epilepsy have low melatonin, which increases following seizures.
Topics: Adult; Epilepsy; Female; Humans; Hydrocortisone; Male; Melatonin; Middle Aged; Radioimmunoassay; Sal | 2000 |
Melatonin and epileptic seizures in patients with acute intermittent porphyria.
Topics: Adult; Aged; Aged, 80 and over; Child; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Hu | 2000 |
Melatonin secretion in relation to sleep in epileptics.
Topics: Adolescent; Adult; Child; Circadian Rhythm; Epilepsy; Female; Humans; Male; Melatonin; Norepinephrin | 1979 |
[Cerebrospinal fluid melatonin in diseases of the nervous system].
Topics: Adolescent; Adult; Arachnoiditis; Brain Diseases; Brain Injuries; Brain Neoplasms; Epilepsy; Female; | 1977 |
The relationship of limbic epilepsy to pineal melatonin functions.
Topics: Epilepsy; Humans; Limbic System; Melatonin; Pineal Gland | 1991 |
Serum melatonin kinetics in epileptic children with or without photosensitivity.
Topics: Child; Child, Preschool; Circadian Rhythm; Dark Adaptation; Epilepsy; Female; Humans; Infant; Light; | 1990 |
Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels.
Topics: Catecholamines; Circadian Rhythm; Epilepsy; Growth Hormone; Humans; Hydrocortisone; Melatonin; Pitui | 1989 |
Could supplementary dietary tryptophan and taurine prevent epileptic seizures?
Topics: Diet; Epilepsy; gamma-Aminobutyric Acid; Humans; Melatonin; Monoamine Oxidase; Pineal Gland; Taurine | 1985 |
Physiological and radiological implications of a low incidence of pineal calcification in Nigeria.
Topics: Adolescent; Adult; Age Factors; Aged; Calcinosis; Calcium; Child; Child, Preschool; Congenital Abnor | 1972 |
On the effect of melatonin upon human brain. Its possible therapeutic implications.
Topics: Administration, Oral; Adolescent; Adult; Brain; Electroencephalography; Electrophysiology; Epilepsy; | 1971 |