melatonin has been researched along with Astrocytoma, Grade IV in 19 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present research, we report that melatonin or its agonist, agomelatine, induced autophagy in A172 and U87-MG glioblastoma cells for a concentration-and time-dependent way, which was significantly attenuated by treatment with luzindole, a melatonin receptor antagonist." | 7.91 | Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells. ( Qi, ZX; Wei, ZX; Zhou, N, 2019) |
| " In spite of its unfavorable biopharmaceutic properties, melatonin (MLT) has demonstrated anticancer effects against glioblastoma." | 7.91 | Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma. ( da Silva, ACG; de Oliveira Junior, ER; Lima, EM; Nascimento, TL; Salomão, MA; Valadares, MC, 2019) |
| "Melatonin is an endogenous indoleamine with an incredible variety of properties." | 6.66 | Melatonin's Antineoplastic Potential Against Glioblastoma. ( Favero, G; Moretti, E; Rezzani, R; Rodella, LF, 2020) |
| "Melatonin (MT) is a pineal hormone with antineoplastic potential." | 5.72 | Melatonin Inhibits the Malignant Progression of Glioblastoma via Regulating miR-16-5p/PIM1. ( Hua, L; Huang, L; Yan, Z; Zhang, X, 2022) |
| "In the present research, we report that melatonin or its agonist, agomelatine, induced autophagy in A172 and U87-MG glioblastoma cells for a concentration-and time-dependent way, which was significantly attenuated by treatment with luzindole, a melatonin receptor antagonist." | 3.91 | Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells. ( Qi, ZX; Wei, ZX; Zhou, N, 2019) |
| " In spite of its unfavorable biopharmaceutic properties, melatonin (MLT) has demonstrated anticancer effects against glioblastoma." | 3.91 | Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma. ( da Silva, ACG; de Oliveira Junior, ER; Lima, EM; Nascimento, TL; Salomão, MA; Valadares, MC, 2019) |
| "Melatonin has been considered in biological processes and in signaling pathways involved in the development of glioma." | 2.66 | The effects of melatonin on signaling pathways and molecules involved in glioma. ( Asemi, Z; Neamati, F, 2020) |
| "Melatonin is an endogenous indoleamine with an incredible variety of properties." | 2.66 | Melatonin's Antineoplastic Potential Against Glioblastoma. ( Favero, G; Moretti, E; Rezzani, R; Rodella, LF, 2020) |
| "Melatonin (MT) is a pineal hormone with antineoplastic potential." | 1.72 | Melatonin Inhibits the Malignant Progression of Glioblastoma via Regulating miR-16-5p/PIM1. ( Hua, L; Huang, L; Yan, Z; Zhang, X, 2022) |
| " Furthermore, the non-cytolytic and non-cytotoxic metronomic dosage of hydroxyurea and temozolomide had increased the DBM therapy outcome by strengthening anti-tumor capability." | 1.62 | A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness. ( Borghetto, V; Costanzo, E; Di Bella, G, 2021) |
| "Melatonin has been associated with various tumors, including brain tumor, and shown to inhibit growth of neuroblastoma cells and gliomas in animal models." | 1.43 | Pineal calcification is associated with pediatric primary brain tumor. ( Johns, J; Johns, NP; Kanpittaya, J; Kitkhuandee, A; Tuntapakul, S, 2016) |
| "Melatonin actions were analysed by viability cell assays, flow cytometry, quantitative PCR for mRNA expression, western blot for protein expression and quantitative and qualitative promoter methylation methods." | 1.39 | Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells. ( Alvarez-Vega, MA; Antolín, I; Fueyo, J; Gomez-Manzano, C; Herrera, F; Martín, V; Rodriguez, C; Sanchez-Sanchez, AM, 2013) |
| "Melatonin can partly inhibit the cytotoxicity of H2O2 and Abeta through its role as a free radical scavenger." | 1.31 | Protective effect of melatonin on neural cells against the cytotoxicity of oxyradicals. ( An, Y; Dai, Q; Han, F; Liu, E; Liu, X; Yang, F, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 9 (47.37) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, Z | 1 |
| Zhang, X | 1 |
| Hua, L | 1 |
| Huang, L | 1 |
| Di Bella, G | 1 |
| Borghetto, V | 1 |
| Costanzo, E | 1 |
| Ghareghani, M | 1 |
| Zibara, K | 1 |
| Reiter, RJ | 1 |
| Rivest, S | 1 |
| Fernandez-Gil, BI | 1 |
| Otamendi-Lopez, A | 1 |
| Bechtle, A | 1 |
| Vazquez-Ramos, CA | 1 |
| Qosja, N | 1 |
| Suarez-Meade, P | 1 |
| Sarabia-Estrada, R | 1 |
| Jentoft, ME | 1 |
| Guerrero-Cázares, H | 1 |
| Escames, G | 1 |
| Schiapparelli, P | 1 |
| Quiñones-Hinojosa, A | 1 |
| Neamati, F | 1 |
| Asemi, Z | 1 |
| Zhou, N | 1 |
| Wei, ZX | 1 |
| Qi, ZX | 1 |
| Anderson, G | 1 |
| Moretti, E | 1 |
| Favero, G | 1 |
| Rodella, LF | 1 |
| Rezzani, R | 1 |
| Wang, C | 1 |
| Zhao, Z | 1 |
| Qi, Q | 1 |
| Wang, J | 2 |
| Kong, Y | 1 |
| Feng, Z | 1 |
| Chen, A | 1 |
| Li, W | 1 |
| Zhang, Q | 1 |
| Huang, B | 1 |
| Li, X | 2 |
| Doğanlar, O | 1 |
| Doğanlar, ZB | 1 |
| Delen, E | 1 |
| Doğan, A | 1 |
| Sung, GJ | 1 |
| Kim, SH | 1 |
| Kwak, S | 1 |
| Park, SH | 1 |
| Song, JH | 1 |
| Jung, JH | 1 |
| Kim, H | 1 |
| Choi, KC | 1 |
| Lai, SW | 1 |
| Liu, YS | 1 |
| Lu, DY | 1 |
| Tsai, CF | 1 |
| de Oliveira Junior, ER | 1 |
| Nascimento, TL | 1 |
| Salomão, MA | 1 |
| da Silva, ACG | 1 |
| Valadares, MC | 1 |
| Lima, EM | 1 |
| Zhang, Y | 1 |
| Liu, Q | 2 |
| Wang, F | 2 |
| Ling, EA | 1 |
| Liu, S | 1 |
| Wang, L | 1 |
| Yang, Y | 1 |
| Yao, L | 1 |
| Chen, X | 2 |
| Shi, W | 1 |
| Gao, M | 1 |
| Hao, A | 2 |
| Martín, V | 1 |
| Sanchez-Sanchez, AM | 1 |
| Herrera, F | 1 |
| Gomez-Manzano, C | 1 |
| Fueyo, J | 1 |
| Alvarez-Vega, MA | 1 |
| Antolín, I | 1 |
| Rodriguez, C | 1 |
| Du, Z | 1 |
| Li, H | 1 |
| Wang, H | 1 |
| Yang, H | 1 |
| Fang, Z | 1 |
| Tuntapakul, S | 1 |
| Kitkhuandee, A | 1 |
| Kanpittaya, J | 1 |
| Johns, J | 1 |
| Johns, NP | 1 |
| Zheng, X | 1 |
| Pang, B | 1 |
| Gu, G | 1 |
| Gao, T | 1 |
| Zhang, R | 1 |
| Pang, Q | 1 |
| An, Y | 1 |
| Liu, E | 1 |
| Liu, X | 1 |
| Yang, F | 1 |
| Han, F | 1 |
| Dai, Q | 1 |
3 reviews available for melatonin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Reduced melatonin levels may facilitate glioblastoma initiation in the subventricular zone.
Topics: Adult; Brain Neoplasms; Female; Glioblastoma; Humans; Lateral Ventricles; Male; Melatonin; Neural St | 2022 |
The effects of melatonin on signaling pathways and molecules involved in glioma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Differentiation; Cell Proliferation; Disease Progression; | 2020 |
Melatonin's Antineoplastic Potential Against Glioblastoma.
Topics: Antineoplastic Agents; Central Nervous System Depressants; Glioblastoma; Humans; Melatonin; Quality | 2020 |
16 other studies available for melatonin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Melatonin Inhibits the Malignant Progression of Glioblastoma via Regulating miR-16-5p/PIM1.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, | 2022 |
A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness.
Topics: Acetazolamide; Antioxidants; Brain Neoplasms; Ditiocarb; Glioblastoma; Humans; Hydroxyurea; Melatoni | 2021 |
Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma.
Topics: Animals; Cell Division; Glioblastoma; Glycolysis; Humans; Hydrogen-Ion Concentration; Melatonin; Mic | 2022 |
Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells.
Topics: Acetamides; Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Dose-Res | 2019 |
The effects of melatonin on signaling pathways and molecules involved in glioma: Melatonin and glioblastoma: pathophysiology and treatment.
Topics: Glioblastoma; Glioma; Humans; Melatonin; Signal Transduction | 2020 |
miR-6858 plays a key role in the process of melatonin inhibition of the malignant biological behavior of glioma.
Topics: Animals; Antioxidants; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Re | 2021 |
The role of melatonin in angio-miR-associated inhibition of tumorigenesis and invasion in human glioblastoma tumour spheroids.
Topics: Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neopla | 2021 |
Inhibition of TFEB oligomerization by co-treatment of melatonin with vorinostat promotes the therapeutic sensitivity in glioblastoma and glioma stem cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Basic Helix-Loop-Helix Leucine Z | 2019 |
Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Melatonin; Mice; Monocytes; Signal | 2019 |
Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma.
Topics: Administration, Intranasal; Administration, Oral; Animals; Antineoplastic Agents; Brain; Cell Line, | 2019 |
Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α.
Topics: Cell Line, Tumor; Cell Movement; Gene Knockdown Techniques; Glioblastoma; Humans; Hypoxia; Hypoxia-I | 2013 |
Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette | 2013 |
Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis.
Topics: Enhancer of Zeste Homolog 2 Protein; Glioblastoma; Humans; Melatonin; Neoplastic Stem Cells; Proto-O | 2016 |
Pineal calcification is associated with pediatric primary brain tumor.
Topics: Adolescent; Brain Neoplasms; Calcinosis; Child; Child, Preschool; Female; Glioblastoma; Humans; Male | 2016 |
Melatonin Inhibits Glioblastoma Stem-like cells through Suppression of EZH2-NOTCH1 Signaling Axis.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Enhancer of Zeste | 2017 |
Protective effect of melatonin on neural cells against the cytotoxicity of oxyradicals.
Topics: Amyloid beta-Peptides; Apoptosis; Cell Survival; Free Radical Scavengers; Glioblastoma; Glutathione; | 2000 |