melatonin has been researched along with Asphyxia Neonatorum in 17 studies
Asphyxia Neonatorum: Respiratory failure in the newborn. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin is a natural neuroprotective hormone, which makes it promising for the treatment of neurodegeneration after asphyxia." | 7.01 | Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia. ( Furmaga-Jabłońska, W; Januszewski, S; Pluta, R; Tarkowska, A, 2023) |
| " Melatonin is a hormone with antioxidant and anti-inflammatory effects that make it a promising molecule for the treatment of perinatal asphyxia." | 5.22 | Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy. ( Cannavò, L; D'angelo, G; Gitto, E; Reiter, RJ, 2022) |
| " Included in this group of conditions is asphyxia, respiratory distress syndrome and sepsis and the review also summarizes the literature related to clinical trials of antioxidant therapies and of melatonin, a highly effective antioxidant and free radical scavenger." | 4.85 | Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. ( Barberi, I; Gitto, E; Gitto, P; Pellegrino, S; Reiter, RJ, 2009) |
| "Melatonin is a natural neuroprotective hormone, which makes it promising for the treatment of neurodegeneration after asphyxia." | 3.01 | Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia. ( Furmaga-Jabłońska, W; Januszewski, S; Pluta, R; Tarkowska, A, 2023) |
| "Melatonin has been shown to be neuroprotective in animal models." | 2.80 | Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. ( Aly, H; Awny, M; El-Dib, M; El-Gohary, T; El-Mashad, AR; Elbatch, M; Elmahdy, H; Hamisa, M; Rowisha, M, 2015) |
| "Melatonin has shown neuroprotective properties in pre-clinical studies of perinatal asphyxia through antioxidant, anti-apoptotic and anti-inflammatory actions." | 2.72 | Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials. ( Ahmed, J; More, K; Pullattayil S, AK; Robertson, NJ, 2021) |
| " Challenges include timing, dosing and administration route for each neuroprotectant." | 2.61 | Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia. ( Cheung, PY; Schmölzer, GM; Solevåg, AL, 2019) |
| "Melatonin is a naturally occurring indolamine with mild antioxidant properties that is neuroprotective in perinatal animals." | 1.40 | Partial neural protection with prophylactic low-dose melatonin after asphyxia in preterm fetal sheep. ( Bennet, L; Booth, LC; Davidson, JO; Drury, PP; Fraser, M; Gunn, AJ; Tan, S; van den Heuij, LG, 2014) |
| "Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions against hypoxic-ischaemic brain injury in animal models." | 1.39 | Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. ( Andorka, C; Bainbridge, A; Cady, EB; Chandrasekaran, M; Faulkner, S; Fleiss, B; Golay, X; Gressens, P; Hristova, M; Lecky-Thompson, L; Powell, E; Price, D; Raivich, G; Robertson, NJ; Thei, L, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 6 (35.29) | 2.80 |
| Authors | Studies |
|---|---|
| Pluta, R | 1 |
| Furmaga-Jabłońska, W | 1 |
| Januszewski, S | 1 |
| Tarkowska, A | 1 |
| Sabir, H | 1 |
| Maes, E | 1 |
| Zweyer, M | 1 |
| Schleehuber, Y | 1 |
| Imam, FB | 1 |
| Silverman, J | 1 |
| White, Y | 1 |
| Pang, R | 1 |
| Pasca, AM | 1 |
| Robertson, NJ | 4 |
| Maltepe, E | 1 |
| Bernis, ME | 1 |
| El Farargy, MS | 1 |
| Soliman, NA | 1 |
| Martini, S | 1 |
| Austin, T | 1 |
| Aceti, A | 1 |
| Faldella, G | 1 |
| Corvaglia, L | 1 |
| D'angelo, G | 2 |
| Cannavò, L | 1 |
| Reiter, RJ | 3 |
| Gitto, E | 3 |
| Ahmed, J | 1 |
| Pullattayil S, AK | 1 |
| More, K | 1 |
| Aridas, JD | 1 |
| Yawno, T | 2 |
| Sutherland, AE | 2 |
| Nitsos, I | 2 |
| Wong, FY | 2 |
| Hunt, RW | 2 |
| Ditchfield, M | 2 |
| Fahey, MC | 2 |
| Malhotra, A | 2 |
| Wallace, EM | 2 |
| Gunn, AJ | 2 |
| Jenkin, G | 2 |
| Miller, SL | 2 |
| Aridas, JDS | 1 |
| Albrecht, M | 1 |
| Zitta, K | 1 |
| Groenendaal, F | 1 |
| van Bel, F | 1 |
| Peeters-Scholte, C | 1 |
| Solevåg, AL | 1 |
| Schmölzer, GM | 1 |
| Cheung, PY | 1 |
| Drury, PP | 1 |
| Davidson, JO | 1 |
| Bennet, L | 1 |
| Booth, LC | 1 |
| Tan, S | 1 |
| Fraser, M | 1 |
| van den Heuij, LG | 1 |
| Aly, H | 1 |
| Elmahdy, H | 1 |
| El-Dib, M | 1 |
| Rowisha, M | 1 |
| Awny, M | 1 |
| El-Gohary, T | 1 |
| Elbatch, M | 1 |
| Hamisa, M | 1 |
| El-Mashad, AR | 1 |
| Hassell, KJ | 1 |
| Ezzati, M | 1 |
| Alonso-Alconada, D | 1 |
| Hausenloy, DJ | 1 |
| Marseglia, L | 1 |
| Manti, S | 1 |
| Pellegrino, S | 1 |
| Gitto, P | 1 |
| Barberi, I | 1 |
| Levene, MI | 1 |
| Faulkner, S | 1 |
| Fleiss, B | 1 |
| Bainbridge, A | 1 |
| Andorka, C | 1 |
| Price, D | 1 |
| Powell, E | 1 |
| Lecky-Thompson, L | 1 |
| Thei, L | 1 |
| Chandrasekaran, M | 1 |
| Hristova, M | 1 |
| Cady, EB | 1 |
| Gressens, P | 1 |
| Golay, X | 1 |
| Raivich, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Melatonin for Neuroprotection in Term Infants With Hypoxic-ischaemic Encephalopathy[NCT03806816] | 100 participants (Anticipated) | Interventional | 2018-12-13 | Recruiting | |||
| Autophagy, Mitophagy, Inflammation and Plasmatic Concentration of Melatonin in Newborn With Metabolic Acidosis at Birth[NCT03897101] | 150 participants (Anticipated) | Observational [Patient Registry] | 2019-03-01 | Recruiting | |||
| A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia Plus Magnesium Sulphate (MgSO4) Versus Therapeutic Hypothermia Plus Placebo in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy[NCT01646619] | Phase 3 | 300 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for melatonin and Asphyxia Neonatorum
| Article | Year |
|---|---|
Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia.
Topics: Animals; Asphyxia; Asphyxia Neonatorum; Brain Injuries; Female; Humans; Hypothermia; Hypoxia-Ischemi | 2023 |
Free radicals and neonatal encephalopathy: mechanisms of injury, biomarkers, and antioxidant treatment perspectives.
Topics: Acetylcysteine; Allopurinol; Animals; Antioxidants; Asphyxia Neonatorum; Biomarkers; Brain Injuries; | 2020 |
Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy.
Topics: Asphyxia; Asphyxia Neonatorum; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant | 2022 |
Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials.
Topics: Asphyxia Neonatorum; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; | 2021 |
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.
Topics: Allopurinol; Asphyxia Neonatorum; Biotin; Cerebral Palsy; Clinical Trials as Topic; Epilepsy; Erythr | 2019 |
Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia.
Topics: Acetylcysteine; Allopurinol; Argon; Asphyxia Neonatorum; Cannabinoids; Erythropoietin; Female; Human | 2019 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia.
Topics: Animals; Antioxidants; Asphyxia Neonatorum; Female; Fetal Growth Retardation; Humans; Infant, Newbor | 2016 |
Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin.
Topics: Animals; Asphyxia Neonatorum; Clinical Trials as Topic; Female; Free Radical Scavengers; Humans; Inf | 2009 |
2 trials available for melatonin and Asphyxia Neonatorum
| Article | Year |
|---|---|
A randomized controlled trial on the use of magnesium sulfate and melatonin in neonatal hypoxic ischemic encephalopathy.
Topics: Asphyxia Neonatorum; Biomarkers; Electroencephalography; Female; Humans; Hypoxia-Ischemia, Brain; In | 2019 |
Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study.
Topics: Asphyxia Neonatorum; Electroencephalography; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, | 2015 |
6 other studies available for melatonin and Asphyxia Neonatorum
| Article | Year |
|---|---|
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemas | 2023 |
Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Melat | 2021 |
Systemic and transdermal melatonin administration prevents neuropathology in response to perinatal asphyxia in newborn lambs.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Melatonin; Neuroprotective Agents; Random All | 2018 |
Partial neural protection with prophylactic low-dose melatonin after asphyxia in preterm fetal sheep.
Topics: Animals; Asphyxia Neonatorum; Brain; Dose-Response Relationship, Drug; Drug Carriers; Ethanol; Femal | 2014 |
Cool treatment for birth asphyxia, but what's next?
Topics: Animals; Asphyxia Neonatorum; Combined Modality Therapy; Erythropoietin; Humans; Hypothermia, Induce | 2010 |
Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Brain; Disease Models, Animal; Energ | 2013 |