melatonin and Anxiety studies

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

Excerpt	Relevance	Reference
"This study investigated the effect of oral melatonin as a premedication before cataract surgery on pain score, anxiety, surgical conditions, and intraocular pressure (IOP) during cataract surgery with phacoemulsification under topical anesthesia."	9.69	The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia. ( Abdelbasset, WK; Golabi, P; Haki, BK; Komilzhonovich, IN; Mahmodi, H; Morwati, S; Motarjemizadeh, Q; Rahmani, N; Sane, S; Suksatan, W; Zaman, GS, 2023)
"Melatonin did not reduce preoperative anxiety in patients undergoing hernia repair."	9.51	Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. ( Gram-Hanssen, A; Holm, MA; Madsen, BK; Rosenberg, J; Zetner, DB, 2022)
"Melatonin showed no prophylactic antidepressant effect following acute coronary syndrome."	9.30	The effect of melatonin on depressive symptoms and anxiety in patients after acute coronary syndrome: The MEDACIS randomized clinical trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Grummedal, O; Hansen, CH; Hansen, JR; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M; Zahid, JA, 2019)
"This study was designed to compare the effects of melatonin and oxazepam in the management of anxiety and insomnia on patients following primary percutaneous coronary intervention (PCI) with a view to providing a safer alternative."	9.27	Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial. ( Ghaeli, P; Solduzian, M; Talasaz, AH; Vejdani, S, 2018)
"This study adds new encouraging data, further supporting the potential use of melatonin premedication in reducing anxiety and improving compliance to induction of anaesthesia in children undergoing surgery."	9.24	Premedication with melatonin vs midazolam: efficacy on anxiety and compliance in paediatric surgical patients. ( Alibrandi, A; Arena, S; Cuzzocrea, F; D'Angelo, G; Gitto, E; Gravina, MR; Gugliandolo, MC; Impellizzeri, P; Larcan, R; Marseglia, L; Montalto, AS; Romeo, C; Russo, T; Vinci, E, 2017)
"The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects."	9.17	A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013)
"To evaluate the effects of melatonin premedication on anxiety and pain scores of patients, operating conditions, and intraocular pressure during cataract surgery under topical anesthesia."	9.17	The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. ( Khezri, MB; Merate, H, 2013)
"Midazolam is more effective than melatonin in reducing children's anxiety at induction of anesthesia."	9.14	Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. ( Hata, J; Herrmann, L; Kain, ZN; Lerman, J; MacLaren, JE; Mayes, L; Rosenbaum, A, 2009)
"Melatonin significantly reduced the anxiety scores (median, interquartile range) from 5, 3."	9.14	Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. ( Ismail, SA; Mowafi, HA, 2009)
" Self-reported anxiety (Spielberger STAI), cardiovascular parameters (BP and pulse rate) and salivary cortisol and melatonin concentrations were assessed before and after reflexology."	9.12	Evaluation of anxiety, salivary cortisol and melatonin secretion following reflexology treatment: a pilot study in healthy individuals. ( Alldridge, LC; Chandrasekharan, S; D'Arcy, V; Fewell, F; Greenwood, CR; McVicar, AJ, 2007)
"Melatonin has been reported to reduce preoperative anxiety."	9.12	Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery. ( Alvisi, R; Bianchi, S; Buccoliero, C; Capuzzo, M; Gragnaniello, D; Schiffino, E; Zanardi, B, 2006)
"To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS)."	9.11	Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. ( Gwee, KA; Ho, KY; Lu, WZ; Moochhalla, S, 2005)
"To assess the effects of melatonin on preoperative and postoperative anxiety compared to placebo or benzodiazepines."	9.05	Melatonin for preoperative and postoperative anxiety in adults. ( Madsen, BK; Møller, AM; Rosenberg, J; Zetner, D, 2020)
"In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study."	9.04	Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976)
"To assess the effect of melatonin on pre- and postoperative anxiety in adults when comparing melatonin with placebo or when comparing melatonin with benzodiazepines."	8.91	Melatonin for pre- and postoperative anxiety in adults. ( Gögenur, I; Halladin, NL; Hansen, MV; Møller, AM; Rosenberg, J, 2015)
"In this study, we aimed to measure the melatonin levels in COVID-19 positive patients and to investigate the relationship of these levels with depression, death anxiety and insomnia."	8.31	Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia. ( Öner, P; Yılmaz, S, 2023)
"Melatonin treatment following AGCI reduces pro-inflammatory factors, Gal-3, motility, and anxiety, therefore it should be considered as supplementary treatment following ischemic stroke."	8.02	Melatonin Decreases Circulating Levels of Galectin-3 and Cytokines, Motor Activity, and Anxiety Following Acute Global Cerebral Ischemia in Male Rats. ( Cervantes, M; Fenton-Navarro, B; Garduño Ríos, D; Letechipía-Vallejo, G; Torner, L, 2021)
""The effect of MElatonin and Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome" trial (MEDACIS) is a multicenter, double-blinded, placebo-controlled, randomized clinical trial."	7.85	The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M, 2017)
"This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters."	7.85	Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. ( Baker, EK; Hazi, A; Prendergast, LA; Richdale, AL, 2017)
"Preclinical studies have shown that melatonin exercised antidepressant-like and anxiolyticlike effects in animal models of anxiety."	7.83	Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2016)
"The present study suggests that melatonin potentiates the beneficial effect of buspirone against immobilization stress-induced, anxiety-like behavioral and oxidative damage in mice possibly by involving a serotonergic mechanism."	7.80	Buspirone along with melatonin attenuates oxidative damage and anxiety-like behavior in a mouse model of immobilization stress. ( Kaur, G; Kumar, A; Rinwa, P, 2014)
"In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100μg/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated."	7.77	The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. ( Coşkun, H; Gündüz, B; Karakaş, A; Kaya, A; Kücük, A, 2011)
" Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)."	7.75	We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009)
" The purpose of this exploratory study was to compare women with breast cancer to healthy control women on measures of salivary cortisol, urinary catecholamines, overnight urinary melatonin, and self-reported sleep quality, symptoms of stress, depression, anxiety and mood disturbance, to determine if discernable patterns of dysregulations across systems were apparent."	7.74	Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls. ( Campbell, TS; Carlson, LE; Garland, SN; Grossman, P, 2007)
"The purpose of the study was to investigate effects of melatonin (MEL) on exploration and anxiety in normotensive Sprague-Dawley (SD) and hypertensive TGR(mREN2)27 (TGR) rats with high activity of renin-angiotensin system."	7.74	Effect of melatonin on exploration and anxiety in normotensive and hypertensive rats with high activity of renin-angiotensin system. ( Krsková, L; Vrabcová, M; Zeman, M, 2007)
"The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively."	7.71	Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001)
"PTSD is considered as a memory disorder within a Pavlovian fear conditioning and extinction framework."	6.55	The Melatonergic System in Anxiety Disorders and the Role of Melatonin in Conditional Fear. ( Huang, F; Li, CQ; Yang, Z, 2017)
"This study investigated the effect of oral melatonin as a premedication before cataract surgery on pain score, anxiety, surgical conditions, and intraocular pressure (IOP) during cataract surgery with phacoemulsification under topical anesthesia."	5.69	The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia. ( Abdelbasset, WK; Golabi, P; Haki, BK; Komilzhonovich, IN; Mahmodi, H; Morwati, S; Motarjemizadeh, Q; Rahmani, N; Sane, S; Suksatan, W; Zaman, GS, 2023)
"Diazepam demonstrated a statistically significant, sustained reduction in anxiety levels compared with placebo ( p = ."	5.69	Efficacy and Safety of Anxiolytics in Mohs Micrographic Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial. ( Guo, D; Kossintseva, I; Zloty, DM, 2023)
"Melatonin did not reduce preoperative anxiety in patients undergoing hernia repair."	5.51	Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. ( Gram-Hanssen, A; Holm, MA; Madsen, BK; Rosenberg, J; Zetner, DB, 2022)
"Diisononyl phthalate (DINP) is a plasticizer that is frequently used as a substitute for other plasticizers whose use is prohibited in certain products."	5.42	Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin. ( Bornehag, CG; Guo, J; Liu, C; Liu, X; Lu, Y; Ma, P; Nanberg, E; Wu, J; Wu, Y; Yan, B; Yang, X; Zhang, Y, 2015)
"Melatonin is a potent antioxidant with neuroprotective activity in animal models of ischemic stroke, which based on its lack of serious toxicity has raised hopes that it might be used for human stroke treatment in the future."	5.35	Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice. ( Abdallah, NB; Bacigaluppi, M; Bassetti, CL; Guo, Z; Hermann, DM; Kilic, E; Kilic, U; Reiter, RJ; Wolfer, DP, 2008)
"treatment with melatonin (4 and 6 mg/kg)."	5.31	Melatonin reduces anxiety induced by lipopolysaccharide in the rat. ( Carta, G; Nava, F, 2001)
"Melatonin showed no prophylactic antidepressant effect following acute coronary syndrome."	5.30	The effect of melatonin on depressive symptoms and anxiety in patients after acute coronary syndrome: The MEDACIS randomized clinical trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Grummedal, O; Hansen, CH; Hansen, JR; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M; Zahid, JA, 2019)
"This study was designed to compare the effects of melatonin and oxazepam in the management of anxiety and insomnia on patients following primary percutaneous coronary intervention (PCI) with a view to providing a safer alternative."	5.27	Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial. ( Ghaeli, P; Solduzian, M; Talasaz, AH; Vejdani, S, 2018)
"Melatonin use did not consistently contribute to pain and anxiety amelioration in all patients."	5.20	Melatonin premedication versus placebo in wisdom teeth extraction: a randomised controlled trial. ( Liaw, CM; Seet, E; Su, C; Tay, S, 2015)
"The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects."	5.17	A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013)
"To evaluate the effects of melatonin premedication on anxiety and pain scores of patients, operating conditions, and intraocular pressure during cataract surgery under topical anesthesia."	5.17	The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. ( Khezri, MB; Merate, H, 2013)
"Melatonin significantly reduced the anxiety scores (median, interquartile range) from 5, 3."	5.14	Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. ( Ismail, SA; Mowafi, HA, 2009)
"Midazolam is more effective than melatonin in reducing children's anxiety at induction of anesthesia."	5.14	Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. ( Hata, J; Herrmann, L; Kain, ZN; Lerman, J; MacLaren, JE; Mayes, L; Rosenbaum, A, 2009)
" Anxiety score as assessed by visual analogue scale (VAS) scored more in the placebo group than both melatonin groups."	5.12	Melatonin premedication and the induction dose of propofol. ( Abdullah, KM; Al-Shaer, AA; Alkatheri, K; Mazen, KF; Turkistani, A, 2007)
"To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS)."	5.11	Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. ( Gwee, KA; Ho, KY; Lu, WZ; Moochhalla, S, 2005)
"Melatonin was not only as effective as midazolam in alleviating preoperative anxiety in children, but it was also associated with a tendency towards faster recovery, lower incidence of excitement postoperatively and a lower incidence of sleep disturbance at week 2 postoperatively."	5.11	Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. ( Albassam, A; Aldammas, F; Alotibi, W; Naguib, M; Riad, W; Samarkandi, A; Thalaj, A, 2005)
"To assess the effects of melatonin on preoperative and postoperative anxiety compared to placebo or benzodiazepines."	5.05	Melatonin for preoperative and postoperative anxiety in adults. ( Madsen, BK; Møller, AM; Rosenberg, J; Zetner, D, 2020)
"In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study."	5.04	Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976)
"To assess the effect of melatonin on pre- and postoperative anxiety in adults when comparing melatonin with placebo or when comparing melatonin with benzodiazepines."	4.91	Melatonin for pre- and postoperative anxiety in adults. ( Gögenur, I; Halladin, NL; Hansen, MV; Møller, AM; Rosenberg, J, 2015)
"In this study, we aimed to measure the melatonin levels in COVID-19 positive patients and to investigate the relationship of these levels with depression, death anxiety and insomnia."	4.31	Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia. ( Öner, P; Yılmaz, S, 2023)
"Melatonin treatment following AGCI reduces pro-inflammatory factors, Gal-3, motility, and anxiety, therefore it should be considered as supplementary treatment following ischemic stroke."	4.02	Melatonin Decreases Circulating Levels of Galectin-3 and Cytokines, Motor Activity, and Anxiety Following Acute Global Cerebral Ischemia in Male Rats. ( Cervantes, M; Fenton-Navarro, B; Garduño Ríos, D; Letechipía-Vallejo, G; Torner, L, 2021)
"Our results demonstrated that melatonin possesses potent protective effect against the depression and anxiety induced by LPS."	3.88	Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress. ( Bahbiti, Y; Benmhammed, H; Berkiks, I; El Hasnaoui, A; El Hessni, A; Mesfioui, A; Mouden, S; Nakache, R; Ouichou, A; Touil, T, 2018)
"This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters."	3.85	Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. ( Baker, EK; Hazi, A; Prendergast, LA; Richdale, AL, 2017)
""The effect of MElatonin and Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome" trial (MEDACIS) is a multicenter, double-blinded, placebo-controlled, randomized clinical trial."	3.85	The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M, 2017)
"Preclinical studies have shown that melatonin exercised antidepressant-like and anxiolyticlike effects in animal models of anxiety."	3.83	Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment. ( Dronjak, S; Jovanovic, P; Spasojevic, N; Stefanovic, B, 2016)
"To study melatonin secretion and its correlations with poststroke cognitive, emotional impairment and sleep quality in the acute period of stroke and to assess treatment efficacy of melaxen."	3.80	[Poststroke cognitive, emotional impairment and sleep quality: efficience of treatment with melaxen]. ( Kulesh, AA; Shestakov, VV, 2014)
" Moreover these rats exhibited anhedonia in a sucrose consumption test, and increased grooming in the open-field test, which reflects an anxiety-like condition."	3.79	Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat. ( Angeles-Castellanos, M; Escobar, C; Salgado-Delgado, R; Tapia-Osorio, A, 2013)
"Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety."	3.78	Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. ( Bedini, A; Comai, S; Fraschini, F; Gobbi, G; Mor, M; Ochoa-Sanchez, R; Rainer, Q; Rivara, S; Spadoni, G; Tarzia, G, 2012)
"In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100μg/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated."	3.77	The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. ( Coşkun, H; Gündüz, B; Karakaş, A; Kaya, A; Kücük, A, 2011)
" After weaning, dams were tested for anxiety, sleep recording or hormone profiling (ACTH, corticosterone and prolactin) and brain sampling (pineal melatonin and hippocampus serotonin)."	3.76	Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams. ( Andersen, ML; Bignotto, M; D'Almeida, V; Martins, PJ; Roizenblatt, S; Tufik, S, 2010)
"6 days post injury) and 23 age- and gender-matched healthy volunteers on polysomnographic sleep measures, salivary dim light melatonin onset (DLMO) time, and self-reported sleep quality, anxiety, and depression."	3.76	Sleep disturbance and melatonin levels following traumatic brain injury. ( Parcell, DL; Phipps-Nelson, J; Ponsford, JL; Rajaratnam, SM; Redman, JR; Shekleton, JA, 2010)
" The rats were assigned to mother groups on day 10 of pregnancy: control (12-h light/dark), LL (light from day 10 to 21 of pregnancy), and LL+Mel (LL and sc injection to the mothers of a daily dose of melatonin, 1 mg/kg body weight at circadian time 12, from day 17 to 21 of pregnancy)."	3.76	Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation. ( Cisternas, CD; Compagnucci, MV; Conti, NR; Ponce, RH; Vermouth, NT, 2010)
" Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)."	3.75	We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009)
"The purpose of the study was to investigate effects of melatonin (MEL) on exploration and anxiety in normotensive Sprague-Dawley (SD) and hypertensive TGR(mREN2)27 (TGR) rats with high activity of renin-angiotensin system."	3.74	Effect of melatonin on exploration and anxiety in normotensive and hypertensive rats with high activity of renin-angiotensin system. ( Krsková, L; Vrabcová, M; Zeman, M, 2007)
" The purpose of this exploratory study was to compare women with breast cancer to healthy control women on measures of salivary cortisol, urinary catecholamines, overnight urinary melatonin, and self-reported sleep quality, symptoms of stress, depression, anxiety and mood disturbance, to determine if discernable patterns of dysregulations across systems were apparent."	3.74	Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls. ( Campbell, TS; Carlson, LE; Garland, SN; Grossman, P, 2007)
"This study describes the effects of melatonin on cocaine-induced anxiety-like behavior and nucleus accumbens (NAc) cAMP levels in rats."	3.71	Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment. ( Giorgetti, M; Zhdanova, IV, 2002)
"The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively."	3.71	Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001)
"Melatonin was shown to be beneficial to sleep quality, sleep duration, and sleep efficiency."	3.01	The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review. ( Browne, G; Cassimatis, M; Orr, R, 2023)
"Melatonin is a natural hormone that regulates circadian rhythms."	2.90	Should Melatonin Be Used as an Alternative Sedative and Anxiolytic Agent in Mandibular Third Molar Surgery? ( Torun, AC; Yüceer, E, 2019)
"Melatonin has been proposed as a premedication alternative to midazolam, preceding anaesthesia induction."	2.82	Melatonin versus midazolam premedication in children undergoing surgery: A pilot study. ( Crisafi, C; D'Angelo, G; Gitto, E; Impellizzeri, P; Manti, S; Marseglia, L; Montalto, AS; Reiter, RJ; Romeo, C, 2016)
"Melatonin was associated with reduced sedative effects, post-operative excitement and improved emergence behaviour, compared to comparator drugs."	2.82	Melatonin for pre-medication in children: a systematic review. ( Bolt, R; Deery, C; Evans, C; Mellor, K; Papaioannou, D; Thomason, A; Wilson, M, 2022)
"Melatonin was less effective than clonidine in reducing patients' anxiety at the induction of anesthesia, whereas clonidine premedication was associated with greater decrease in heart rate and blood pressure."	2.80	Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled-infusions. ( Bienert, A; Grześkowiak, E; Józefowicz, M; Kokot, ZJ; Kusza, K; Matysiak, J; Pachutko, A; Przybyłowski, K; Wawrzyniak, K; Wiczling, P, 2015)
"Melatonin treatment for two months significantly improved sleep quality scores measured by the NHSMI test (1."	2.74	Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. ( Aramburu, O; Garzón, C; Guerrero, JM; Guzmán, T, 2009)
"Melatonin has sedative, analgesic, antiinflammatory, antioxidative, and chronobiotic effects."	2.73	The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. ( Auzani, JA; Caumo, W; Hidalgo, MP; Londero, G; Monteiro, CA; Moreira, NL; Ribeiro, DF; Torres, F, 2007)
"PTSD is considered as a memory disorder within a Pavlovian fear conditioning and extinction framework."	2.55	The Melatonergic System in Anxiety Disorders and the Role of Melatonin in Conditional Fear. ( Huang, F; Li, CQ; Yang, Z, 2017)
"Melatonin is a neurohormone synthesized in the pineal gland during the dark period in all species, including humans."	2.42	Therapeutic perspectives for melatonin agonists and antagonists. ( Atkinson, J; Boutin, JA; Casteilla, L; Delagrange, P; Lesieur, D; Misslin, R; Pellissier, S; Pénicaud, L; Renard, P, 2003)
"Melatonin treatment, however, improved their nursing behaviour and reduced their plasma corticosterone levels."	1.91	Postnatal melatonin administration to stressed dams for ameliorating risk-taking behaviour in rat pups through maternal care improvement. ( Bagheri, F; Goudarzi, I, 2023)
"Melatonin treatment increased hippocampal SIRT1 and TFAM expression and enhanced mtDNA copy number in the hippocampus."	1.51	Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. ( Ansari Dezfouli, M; Farahmandfar, M; Khodagholi, F; Zahmatkesh, M, 2019)
"Fluoxetine and melatonin treatments decreased TBARS in both cortices."	1.46	The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices. ( Boudah, A; Jasmin, L; Rebai, R, 2017)
"To explore the dynamics of hemostasis in patients with acute coronary syndrome (ACS) in the combination with anxiety and depressive disorders (ADD) during therapy with valdoxan (agomelatine)."	1.42	[An effect of valdoxan on the hemostasis in patients with acute coronary syndrome in the combination with anxiety and depressive disorders]. ( Petrova, MM; Piliugina, MS; Savchenko, AA; Shimohina, NY, 2015)
"Similarly, amyloid plaque loads in hippocampus and frontal cortex, as well as plasma Aβ1-42 levels, were significantly reduced by MEL in a receptor-independent manner, in contrast to MEL's efficacy in reducing cortical antioxidant gene expression (Catalase, SOD1, Glutathione Peroxidase-1, Nrf2) only when receptors were present."	1.42	Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. ( Bradshaw, PC; Delic, V; O'Neal-Moffitt, G; Olcese, J, 2015)
"Diisononyl phthalate (DINP) is a plasticizer that is frequently used as a substitute for other plasticizers whose use is prohibited in certain products."	1.42	Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin. ( Bornehag, CG; Guo, J; Liu, C; Liu, X; Lu, Y; Ma, P; Nanberg, E; Wu, J; Wu, Y; Yan, B; Yang, X; Zhang, Y, 2015)
"Anxiety and seizures are closely similar neurobehavioral disorders and are regulated by limbic system."	1.40	Differential neuromodulatory role of NO in anxiety and seizures: an experimental study. ( Gulati, K; Ray, A, 2014)
"Melatonin is a hormone with well-known chronobiotic and hypnotic effects."	1.40	Chronobiology, cognitive function and depressive symptoms in surgical patients. ( Hansen, MV, 2014)
"Melatonin treatment (4 mg/kg/day, i."	1.39	Effects of melatonin on behavioral changes of neonatal rats in a model of cortical dysplasia. ( Aci, A; Aktekin, B; Bingol, CA; Karadeli, HH; Kilic, E; Uzar, E; Yilmaz, B, 2013)
"Diazinon is an organophosphorous pesticide with a prominent toxicity on many body organs."	1.39	Melatonin protects against diazinon-induced neurobehavioral changes in rats. ( Ahmed, HI; Ahmed, MA; El-Morsy, EM, 2013)
"Melatonin has been mainly used for alleviating some disorders related with insomnia and circadian rhythmicity."	1.39	Behavioural actions of two new 1-N substituted analogues of melatonin. ( Bustamante-García, R; Lira-Rocha, AS; Naranjo-Rodríguez, EB; Ortiz-Osornio, A; Picazo, O, 2013)
"Treatment with melatonin (5 and 10 mg/kg, ip) significantly improved locomotor activity, weight loss and antianxiety effect as compared to control (sleep deprived)."	1.37	Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behavior modification and oxidative damage in mice. ( Kumar, A; Kumar, P; Singh, A, 2011)
"Treatment with melatonin (5 mg/kg and 10 mg/kg, ip) significantly improved locomotor activity, weight loss and antianxiety effect as compared with control (sleep-deprived)."	1.35	Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. ( Kumar, A; Singh, A, 2009)
"Melatonin is a potent antioxidant with neuroprotective activity in animal models of ischemic stroke, which based on its lack of serious toxicity has raised hopes that it might be used for human stroke treatment in the future."	1.35	Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice. ( Abdallah, NB; Bacigaluppi, M; Bassetti, CL; Guo, Z; Hermann, DM; Kilic, E; Kilic, U; Reiter, RJ; Wolfer, DP, 2008)
"treatment with melatonin (4 and 6 mg/kg)."	1.31	Melatonin reduces anxiety induced by lipopolysaccharide in the rat. ( Carta, G; Nava, F, 2001)
"Analgesic overuse, insomnia, depression, and anxiety are disorders that are often comorbid with CM."	1.31	Hypothalamic involvement in chronic migraine. ( Abucham, J; Cipolla-Neto, J; Peres, MF; Sanchez del Rio, M; Seabra, ML; Silberstein, SD; Tufik, S; Zukerman, E, 2001)

Research

Studies (119)

Authors

Clinical Trials (26)

Trial Overview

Trial Outcomes

Preoperative Anxiety

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.84)	18.7374
1990's	5 (4.20)	18.2507
2000's	34 (28.57)	29.6817
2010's	56 (47.06)	24.3611
2020's	23 (19.33)	2.80

Authors	Studies
Slyepchenko, A	1
Minuzzi, L	1
Reilly, JP	1
Frey, BN	1
Mellor, K	1
Papaioannou, D	1
Thomason, A	1
Bolt, R	1
Evans, C	1
Wilson, M	1
Deery, C	1
Borisova, AB	1
Veltishchev, DY	1
Lisitsyna, TA	1
Reshetnyak, TM	1
Seravina, OF	1
Kovalevskaya, OB	1
Cheldieva, FA	1
Abramkin, AA	1
Bokhan, NA	1
Roshchina, OV	1
Simutkin, GG	1
Levchuk, LA	1
Ivanova, SA	1
Holm, MA	1
Gram-Hanssen, A	1
Madsen, BK	2
Zetner, DB	1
Rosenberg, J	6
Cassimatis, M	1
Browne, G	1
Orr, R	1
Sane, S	1
Motarjemizadeh, Q	1
Komilzhonovich, IN	1
Abdelbasset, WK	1
Zaman, GS	1
Suksatan, W	1
Morwati, S	1
Haki, BK	1
Rahmani, N	1
Golabi, P	1
Mahmodi, H	1
Repova, K	1
Baka, T	1
Krajcirovicova, K	1
Stanko, P	1
Aziriova, S	1
Reiter, RJ	4
Simko, F	1
Yılmaz, S	1
Öner, P	1
Bagheri, F	1
Goudarzi, I	1
de Oliveira Moura Araújo, E	1
Gavioli, EC	1
Holanda, VAD	1
da Silva, VC	1
Oliveira Nunes Messias, TB	1
Dutra, LMG	1
de Oliveira, MC	1
Ramos do Egypto Queiroga, RC	1
Guerra, GCB	1
Soares, JKB	1
Albzea, W	1
Almonayea, L	1
Aljassar, M	1
Atmeh, M	1
Al Sadder, K	1
AlQattan, Y	1
Alhajaji, R	1
AlNadwi, H	1
Alnami, I	1
Alhajaji, F	1
Guo, D	1
Zloty, DM	1
Kossintseva, I	1
Madsen, MT	3
Zahid, JA	1
Hansen, CH	1
Grummedal, O	1
Hansen, JR	1
Isbrand, A	2
Andersen, UO	2
Andersen, LJ	2
Taskiran, M	2
Simonsen, E	2
Gögenur, I	6
Ergenc, M	1
Ozacmak, HS	1
Turan, I	1
Ozacmak, VH	1
Meng, C	1
Wang, W	1
Hao, Z	1
Liu, H	1
Bui Thi, NH	1
Nguyen Thi, NA	1
Audira, G	1
Siregar, P	1
Liang, ST	1
Huang, JC	1
Hsiao, CD	1
Kennert, BA	1
Harshorne, TS	1
Kanouse, S	1
Johnson, C	1
Touitou, Y	1
Touitou, D	1
Reinberg, A	1
Laudisio, D	1
Barrea, L	1
Pugliese, G	1
Aprano, S	1
Castellucci, B	1
Savastano, S	1
Colao, A	1
Muscogiuri, G	1
Zetner, D	1
Møller, AM	2
Fenton-Navarro, B	1
Garduño Ríos, D	1
Torner, L	1
Letechipía-Vallejo, G	1
Cervantes, M	1
Bertani, DE	1
De Novellis, AMP	1
Farina, R	1
Latella, E	1
Meloni, M	1
Scala, C	1
Valeo, L	1
Galeazzi, GM	1
Ferrari, S	1
Vanderheyden, WM	1
Kehoe, M	1
Vanini, G	1
Britton, SL	1
Koch, LG	1
Wang, X	1
Wang, Z	1
Cao, J	1
Dong, Y	1
Chen, Y	1
Baker, EK	1
Richdale, AL	1
Hazi, A	1
Prendergast, LA	1
Impellizzeri, P	2
Vinci, E	1
Gugliandolo, MC	1
Cuzzocrea, F	1
Larcan, R	1
Russo, T	1
Gravina, MR	1
Arena, S	1
D'Angelo, G	2
Gitto, E	2
Montalto, AS	2
Alibrandi, A	1
Marseglia, L	2
Romeo, C	2
Nie, L	1
Wei, G	1
Peng, S	1
Qu, Z	1
Yang, Y	1
Yang, Q	1
Huang, X	1
Liu, J	1
Zhuang, Z	1
Yang, X	2
Won, J	1
Jin, Y	1
Choi, J	1
Park, S	1
Lee, TH	1
Lee, SR	1
Chang, KT	1
Hong, Y	1
Rebai, R	1
Jasmin, L	1
Boudah, A	1
Berkiks, I	1
Benmhammed, H	1
Mesfioui, A	1
Ouichou, A	1
El Hasnaoui, A	1
Mouden, S	1
Touil, T	1
Bahbiti, Y	1
Nakache, R	1
El Hessni, A	1
Grima, NA	1
Rajaratnam, SMW	1
Mansfield, D	1
Sletten, TL	1
Spitz, G	1
Ponsford, JL	2
Posadzki, PP	1
Bajpai, R	1
Kyaw, BM	1
Roberts, NJ	1
Brzezinski, A	1
Christopoulos, GI	1
Divakar, U	1
Bajpai, S	1
Soljak, M	1
Dunleavy, G	1
Jarbrink, K	1
Nang, EEK	1
Soh, CK	1
Car, J	1
Ghaeli, P	1
Solduzian, M	1
Vejdani, S	1
Talasaz, AH	1
Ghaderi, A	1
Banafshe, HR	1
Mirhosseini, N	1
Motmaen, M	1
Mehrzad, F	1
Bahmani, F	1
Aghadavod, E	1
Mansournia, MA	1
Karimi, MA	1
Asemi, Z	1
Ilieva, K	1
Tchekalarova, J	1
Atanasova, D	1
Kortenska, L	1
Atanasova, M	1
Ansari Dezfouli, M	1
Zahmatkesh, M	1
Farahmandfar, M	1
Khodagholi, F	1
Baroni, A	1
Torun, AC	1
Yüceer, E	1
Brignardello-Petersen, R	1
Stein, DJ	1
Picarel-Blanchot, F	1
Kennedy, SH	1
Khezri, MB	1
Merate, H	1
Tapia-Osorio, A	1
Salgado-Delgado, R	1
Angeles-Castellanos, M	1
Escobar, C	1
Bilu, C	1
Kronfeld-Schor, N	3
Karadeli, HH	1
Aktekin, B	1
Yilmaz, B	1
Kilic, E	2
Uzar, E	1
Aci, A	1
Bingol, CA	1
Ahmed, MA	1
Ahmed, HI	1
El-Morsy, EM	1
Andersen, LP	2
Aubrecht, TG	1
Weil, ZM	2
Nelson, RJ	2
Hansen, MV	3
Andersen, LT	1
Hageman, I	1
Rasmussen, LS	1
Bokmand, S	1
Werner, MU	1
Kulesh, AA	1
Shestakov, VV	1
O'Neal-Moffitt, G	2
Pilli, J	1
Kumar, SS	1
Olcese, J	2
Gulati, K	1
Ray, A	1
Kumar, A	3
Kaur, G	1
Rinwa, P	1
Adamah-Biassi, EB	1
Hudson, RL	1
Dubocovich, ML	1
Bienert, A	1
Wawrzyniak, K	1
Wiczling, P	1
Przybyłowski, K	1
Kokot, ZJ	1
Matysiak, J	1
Pachutko, A	1
Józefowicz, M	1
Kusza, K	1
Grześkowiak, E	1
Halladin, NL	1
Stefani, LC	1
Muller, S	1
Torres, IL	1
Razzolini, B	1
Rozisky, JR	1
Fregni, F	1
Markus, R	1
Caumo, W	3
Shimohina, NY	1
Petrova, MM	1
Savchenko, AA	1
Piliugina, MS	1
Delic, V	1
Bradshaw, PC	1
Ma, P	1
Liu, X	1
Wu, J	1
Yan, B	1
Zhang, Y	1
Lu, Y	1
Wu, Y	1
Liu, C	1
Guo, J	1
Nanberg, E	1
Bornehag, CG	1
dela Peña, IJ	1
Hong, E	1
de la Peña, JB	1
Kim, HJ	1
Botanas, CJ	1
Hong, YS	1
Hwang, YS	1
Moon, BS	1
Cheong, JH	1
Manti, S	1
Crisafi, C	1
Chojnacki, C	1
Walecka-Kapica, E	1
Klupinska, G	1
Pawlowicz, M	1
Blonska, A	1
Chojnacki, J	1
Seet, E	1
Liaw, CM	1
Tay, S	1
Su, C	1
Yuan, M	1
Liu, LJ	1
Xu, LZ	1
Guo, TY	1
Yue, XD	1
Li, SX	1
Voiculescu, SE	1
Le Duc, D	1
Roșca, AE	1
Zeca, V	1
Chiţimuș, DM	1
Arsene, AL	1
Drăgoi, CM	1
Nicolae, AC	1
Zăgrean, L	1
Schöneberg, T	1
Zăgrean, AM	1
Huang, F	1
Yang, Z	1
Li, CQ	1
Spasojevic, N	1
Stefanovic, B	1
Jovanovic, P	1
Dronjak, S	1
Ashkenazy, T	2
Einat, H	2
Rimmele, U	1
Spillmann, M	1
Bärtschi, C	1
Wolf, OT	1
Weber, CS	1
Ehlert, U	1
Wirtz, PH	1
Levandovski, R	1
Hidalgo, MP	2
Garzón, C	1
Guerrero, JM	1
Aramburu, O	1
Guzmán, T	1
Naguib, M	4
Goldstein, PA	1
Ismail, SA	1
Mowafi, HA	1
Kain, ZN	1
MacLaren, JE	1
Herrmann, L	1
Mayes, L	1
Rosenbaum, A	1
Hata, J	1
Lerman, J	1
Singh, A	2
Owen, RT	1
Roizenblatt, S	1
Andersen, ML	1
Bignotto, M	1
D'Almeida, V	1
Martins, PJ	1
Tufik, S	2
Shekleton, JA	1
Parcell, DL	1
Redman, JR	1
Phipps-Nelson, J	1
Rajaratnam, SM	1
Cisternas, CD	1
Compagnucci, MV	1
Conti, NR	1
Ponce, RH	1
Vermouth, NT	1
Karakaş, A	1
Coşkun, H	1
Kaya, A	1
Kücük, A	1
Gündüz, B	1
Kumar, P	1
Bedrosian, TA	1
Herring, KL	1
Ochoa-Sanchez, R	1
Rainer, Q	1
Comai, S	1
Spadoni, G	1
Bedini, A	1
Rivara, S	1
Fraschini, F	1
Mor, M	1
Tarzia, G	1
Gobbi, G	1
Bustamante-García, R	1
Naranjo-Rodríguez, EB	1
Lira-Rocha, AS	1
Ortiz-Osornio, A	1
Picazo, O	1
Arushanian, ÉB	1
Naumov, SS	1
Faians, AA	1
Zhdanova, IV	1
Giorgetti, M	1
Delagrange, P	3
Atkinson, J	1
Boutin, JA	1
Casteilla, L	1
Lesieur, D	2
Misslin, R	3
Pellissier, S	1
Pénicaud, L	1
Renard, P	2
Bianchi-Demicheli, F	1
Lüdicke, F	1
Campana, A	1
Spence, DW	1
Kayumov, L	1
Chen, A	1
Lowe, A	1
Jain, U	1
Katzman, MA	1
Shen, J	1
Perelman, B	1
Shapiro, CM	1
Becker, C	1
Andre, J	1
Zeau, B	1
Rettori, MC	3
Guardiola-Lemaitre, B	2
Hamon, M	2
Benoliel, JJ	1
Millan, MJ	1
Brocco, M	1
Gobert, A	1
Dekeyne, A	1
Samarkandi, A	1
Riad, W	1
Thalaj, A	1
Alotibi, W	1
Aldammas, F	1
Albassam, A	1
Saito, S	1
Tachibana, T	1
Choi, YH	1
Denbow, DM	1
Furuse, M	1
Lu, WZ	1
Gwee, KA	1
Moochhalla, S	1
Ho, KY	1
Loiseau, F	1
Le Bihan, C	1
Thiébot, MH	1
Payne, JK	1
Capuzzo, M	1
Zanardi, B	1
Schiffino, E	1
Buccoliero, C	1
Gragnaniello, D	1
Bianchi, S	1
Alvisi, R	1
Jung, MJ	1
Shin, BC	1
Kim, YS	1
Shin, YI	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309]	Phase 3	25 participants (Actual)	Interventional	2016-07-31	Completed
SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477]		40 participants (Anticipated)	Interventional	2024-07-31	Not yet recruiting
Anxiolytic and Analgesic Effects of Melatonin: A Randomized, Double-blinded, Placebo-controlled Clinical Study[NCT02386319]	Phase 3	36 participants (Actual)	Interventional	2016-08-31	Completed
Perioperative Analgesic and Anxiolytic Effect of Melatonin in Patients Undergoing Lumbar Laminectomy[NCT01126294]		84 participants (Anticipated)	Interventional	2010-04-30	Recruiting
Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950]		104 participants (Anticipated)	Interventional	2017-06-26	Recruiting
The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome[NCT02451293]	Phase 2/Phase 3	252 participants (Actual)	Interventional	2016-01-18	Completed
Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit[NCT03659760]		40 participants (Anticipated)	Interventional	2018-09-03	Recruiting
The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy[NCT03115034]	Phase 4	60 participants (Actual)	Interventional	2016-06-01	Completed
The Adjunctive Use of Systemic Melatonin Therapy in the Treatment of Periodontitis Associated With Obesity (Clinical and Immunological Study).[NCT04788979]	Phase 1/Phase 2	80 participants (Anticipated)	Interventional	2021-04-01	Not yet recruiting
A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832]		30 participants (Anticipated)	Interventional	2016-09-21	Completed
Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery[NCT04791943]	Phase 2	60 participants (Anticipated)	Interventional	2021-05-12	Recruiting
The Effect of the Anesthesia Modality Used in Women Giving Birth Under Caesarian Section on Postpartum Depression and/or Postoperative Melatonin Levels[NCT04278456]		300 participants (Anticipated)	Observational [Patient Registry]	2020-03-21	Recruiting
Role of Endogenous Melatonin Level in Preoperative and Postoperative Anxiety in Bariatric Surgery Patients[NCT03109054]		50 participants (Anticipated)	Observational	2017-03-15	Enrolling by invitation
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599]	Phase 2	86 participants (Actual)	Interventional	2016-07-31	Completed
Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.[NCT03107702]		35 participants (Anticipated)	Observational	2017-03-29	Enrolling by invitation
Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465]		50 participants (Actual)	Interventional	2012-02-29	Completed
Self-acupressure for Cancer-related Symptom Cluster of Insomnia, Depression, and Anxiety in Cancer Patients: a Feasibility Randomized Controlled Trial[NCT03823456]		114 participants (Anticipated)	Interventional	2018-12-04	Recruiting
The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT[NCT04034771]	Phase 3	38 participants (Actual)	Interventional	2018-01-01	Completed
Melatonin and Ulcerative Colitis: A Pilot Clinical Trial[NCT00790478]	Phase 2	3 participants (Actual)	Interventional	2009-01-31	Terminated
The Effect of Preoperative Binaural Sound on Propofol Dose Required for Induction of General Anesthesia: a Randomized, Placebo-controlled Trial[NCT05431881]		76 participants (Anticipated)	Interventional	2022-07-05	Recruiting
A Randomised Double-blind Placebo-controlled Trial on Encapsulated Lemon Balm Efficacy and Tolerance on Sleep Quality Changes, and Mood and Wellbeing Effects Using Objective and Subjective Measures[NCT05422599]		99 participants (Actual)	Interventional	2022-05-05	Completed
The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery: a Prospective Randomised Controlled Cohort Study[NCT02424071]	Phase 4	60 participants (Actual)	Interventional	2015-07-31	Completed
Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone: a Randomized, Double Blind Placebo Controlled Study[NCT01486615]	Phase 4	80 participants (Actual)	Interventional	2011-10-31	Completed
Benefice Assessment of Repetitive Transcranial Magnetic Stimulation Used as an Additional Procedure to Rehabilitation Exercises in Patients Suffering From Fibromyalgia[NCT01308801]		42 participants (Actual)	Interventional	2011-04-30	Completed
Evaluation of Spa Therapy in the Treatment of Fibromyalgia : a Randomized, Controlled, Open Multicenter Study[NCT02265029]		220 participants (Actual)	Interventional	2014-09-30	Completed
"Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316]	Phase 2	31 participants (Actual)	Interventional	2015-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The State scale of the State-Trait Anxiety Inventory (STAI). Construct: Current level of anxiety. Scale range: 20-40 (higher scores indicate higher level of current anxiety) Scores are calculated according to the STAI scoring manual by adding point from each item (possible point for each item is 1-4)." (NCT02386319)
Timeframe: 60 minutes preoperative

Postoperative Hospital Stay

Intervention	score on a scale (Median)
Melatonin	27
Placebo	28

Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days

Changes in C-reactive Protein (CRP) Levels

Intervention	days (Median)
Morphine	7
Levobupivacaine	7

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Cognitive Function

Intervention	mg/L (Median)
	Before surgery	24 h after surgery	72 h after surgery	120 h after surgery
Levobupivacaine	57.8	98.1	95	54.6
Morphine	57.2	106.2	118.5	66.9

"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery

Changes in Fibrinogen Concentrations in Peripheral Blood

Intervention	score on a scale (Median)
	Before surgery	24 h after surgery	48 h after surgery	72 h after surgery	96 h after surgery	120 h after surgery
Levobupivacaine	22	22	21	21	21	22
Morphine	21	20	20	20	20	20

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Pain Intensity

Intervention	g/L (Median)
	Before surgery	24 h after surgery	72 h after surgery	120 h after surgery
Levobupivacaine	4.5	4.7	5.2	5
Morphine	5.5	5.3	5.7	5.4

"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge

Interleukin-6 Concentration in Peripheral Blood.

Intervention	score on a scale (Median)
	3,6,9,12,15,18,21 and 24h after surgery	27,30,33,36,39,42,45 and 48h after surgery	51,54,57,60,63,66,69 and 72h after surgery	4. postoperative day (every 8 hours)	5. postoperative day (every 8 hours)	6. postoperative day (every 8 hours)	Day of discharge
Levobupivacaine	0.6	0.5	0.5	0.3	0	0	0
Morphine	1.4	1.5	1.4	1.4	1.4	1.3	1

Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery

Perioperative Sleep Efficiency

Intervention	pg/ml (Median)
	Before surgery	24h after surgery	72h after surgery
Levobupivacaine	26.6	97.7	30.5
Morphine	27.2	104	50

Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery

Amount of Propofol Consumption

Intervention	minutes (Mean)
Study: Melatonin	20
Control: Placebo	-55

Dose of propofol needed for loss of response to verbal command was noted at the time of induction of general anesthesia. The lesser the propofol needed for the loss of response to verbal command, the better the outcome. (NCT01486615)
Timeframe: 1 - 2 hour after premedication

Change in VAS Anxiety Score Relative to Baseline After Premedication

Intervention	mg (Mean)
Melatonin	79.2
Melatonin and Alprazolam	65.5
Alprazolam	59.0
Placebo	75.8

VAS (Visual Analogue Score) Anxiety Scale is a 10 cm long scale with two sides, the patient side (front) and the clinicians side (back). The extremes of the front are colored as white and black with a gradual darkening of color from white to black. The back is marked in centimeter from 0 to 10 and 0 correlates with white color (no anxiety at all) and 10 correlates to black color (anxiety as bad as ever can be) on the front. As anxiety is worsened, the color is darker and score is more. The maximum score is 10 and minimum 0. The patient is asked to point on the scale according to his anxiety level. The anxiety score is the correlating number on the clinicians side. The more the reduction in anxiety from baseline, the better the outcome. (NCT01486615)
Timeframe: Change from baseline in VAS anxiety score at 15 minutes after premedication

Change in VAS Anxiety Score Relative to Baseline at 30 Minutes After Premedication

Intervention	Centimeter (Mean)
Melatonin	0.35
Melatonin and Alprazolam	0.70
Alprazolam	0.65
Placebo	0.25

VAS (Visual Analogue Score) Anxiety Scale is a 10 cm long scale with two sides, the patient side (front) and the clinicians side (back). The extremes of the front are colored as white and black with a gradual darkening of color from white to black. The back is marked in centimeter from 0 to 10 and 0 correlates with white color (no anxiety at all) and 10 correlates to black color (anxiety as bad as ever can be) on the front. As anxiety is worsened, the color is darker and score is more. The maximum score is 10 and minimum 0. The patient is asked to point on the scale according to his anxiety level. The anxiety score is the correlating number on the clinicians side. The more the reduction in anxiety from baseline, the better the outcome. (NCT01486615)
Timeframe: Changes from baseline in VAS anxiety score at 30 minutes after premedication

Change in VAS Anxiety Score Relative to Baseline at One Hour After Premedication

Intervention	centimeter (Mean)
Melatonin	1.15
Melatonin and Alprazolam	1.72
Alprazolam	1.62
Placebo	0.82

VAS (Visual Analogue Score) Anxiety Scale is a 10 cm long scale with two sides, the patient side (front) and the clinicians side (back). The extremes of the front are colored as white and black with a gradual darkening of color from white to black. The back is marked in centimeter from 0 to 10 and 0 correlates with white color (no anxiety at all) and 10 correlates to black color (anxiety as bad as ever can be) on the front. As anxiety is worsened, the color is darker and score is more. The maximum score is 10 and minimum 0. The patient is asked to point on the scale according to his anxiety level. The anxiety score is the correlating number on the clinicians side. The more the reduction in anxiety from baseline, the better the outcome. (NCT01486615)
Timeframe: Changes from baseline in VAS anxiety score at one hour after premedication

Number of Patients With Intact Memory

Intervention	Centimeter (Mean)
Melatonin	1.80
Melatonin and Alprazolam	2.92
Alprazolam	2.35
Placebo	0.85

Number of patients who recalled or recognized the picture number five shown one hour after premedication. The more the number of patients with intact memory, the better the outcome. (NCT01486615)
Timeframe: 24 hour after surgery

Number of Patients With Loss of Memory for Being Transferred to Operating Room.

Intervention	Participants (Number)
Melatonin	13
Melatonin and Alprazolam	4
Alprazolam	5
Placebo	14

Patients were asked whether they recalled the event of being transferred to the operating room before anaesthesia. The lesser the number of patients with amnesia, the better the outcome. (NCT01486615)
Timeframe: 24 hour after surgery

Orientation Score

Intervention	Participants (Number)
Melatonin	1
Melatonin and Alprazolam	5
Alprazolam	4
Placebo	0

Orientation was assessed with a 3 point scale (0=none, 1=orientation in either time or place, 2=orientation in both). Minimum score is 0 and maximum is 2. The lesser the score, the lesser the effect on patients cognition and the better the outcome. (NCT01486615)
Timeframe: Orientation score at one hour after premedication

Sedation Score at One Hour After Premedication

Intervention	units on a scale (Median)
Melatonin	2
Melatonin and Alprazolam	2
Alprazolam	2
Placebo	2

Sedation level was assessed with a 5 point scale (0=alert, 1=arouses to voice, 2=arouses with gentle tactile stimulation, 3=arouses with vigorous tactile stimulation, 4=lack of responsiveness). Minimum score is 0 and Maximum is 4. The lesser the score, the better the outcome. (NCT01486615)
Timeframe: Sedation score at 1 hour after the premedication

Headache Diary Compliance Rate

Intervention	units on a scale (Median)
Melatonin	0.5
Melatonin and Alprazolam	1
Alprazolam	1
Placebo	0

Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study

Medication Adherence as Measured by Number of Openings Per Participant

Intervention	Participants (Count of Participants)
Melatonin	11
Placebo	10

eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"

Number of Migraine/Migrainous Days Per 28 Day Period

Intervention	Mean Number of Openings (Mean)
Melatonin	39
Placebo	60

Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment

Number of Minutes to Sleep Onset

Intervention	days (Mean)
Melatonin	3.6
Placebo	4.9

Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks

Article	Year
Melatonin for pre-medication in children: a systematic review. BMC pediatrics, 2022, 02-24, Volume: 22, Issue:1 Topics: Adult; Anesthesia; Anti-Anxiety Agents; Anxiety; Child; Humans; Hypnotics and Sedatives; Melatonin	2022
The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review. Archives of physical medicine and rehabilitation, 2023, Volume: 104, Issue:2 Topics: Adolescent; Adult; Anxiety; Brain Injuries, Traumatic; Humans; Melatonin; Sleep; Sleep Wake Disorder	2023
Melatonin as a Potential Approach to Anxiety Treatment. International journal of molecular sciences, 2022, Dec-19, Volume: 23, Issue:24 Topics: Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Free Radicals; Melatonin	2022
Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Medicina (Kaunas, Lithuania), 2023, Jun-01, Volume: 59, Issue:6 Topics: Analgesics; Anxiety; Cesarean Section; Female; Humans; Melatonin; Pain, Postoperative; Pregnancy; Ra	2023
A practical nutritional guide for the management of sleep disturbances in menopause. International journal of food sciences and nutrition, 2021, Volume: 72, Issue:4 Topics: Adult; Aged; Anxiety; Depression; Diet; Female; Humans; Male; Melatonin; Menopause; Middle Aged; Obe	2021
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
Melatonin for preoperative and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi	2020
"Shedding Light on Light": A Review on the Effects on Mental Health of Exposure to Optical Radiation. International journal of environmental research and public health, 2021, 02-09, Volume: 18, Issue:4 Topics: Anxiety; Anxiety Disorders; Circadian Rhythm; Humans; Melatonin; Mental Health	2021
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans. International journal of molecular sciences, 2017, Jun-20, Volume: 18, Issue:6 Topics: Anxiety; Autism Spectrum Disorder; Circadian Clocks; Circadian Rhythm; Fragile X Mental Retardation	2017
Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC medicine, 2018, 02-05, Volume: 16, Issue:1 Topics: Anxiety; Circadian Rhythm; Humans; Melatonin; Quality of Life	2018
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
A systematic review of peri-operative melatonin. Anaesthesia, 2014, Volume: 69, Issue:10 Topics: Anxiety; Humans; Melatonin; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as	2014
Melatonin for pre- and postoperative anxiety in adults. The Cochrane database of systematic reviews, 2015, Apr-09, Issue:4 Topics: Adult; Anti-Anxiety Agents; Anxiety; Clonidine; Drug Administration Schedule; Humans; Melatonin; Mid	2015
The Melatonergic System in Anxiety Disorders and the Role of Melatonin in Conditional Fear. Vitamins and hormones, 2017, Volume: 103 Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Extinction, Psychological; Fear; Hippocamp	2017
Agomelatine: a novel pharmacological approach to treating depression. Drugs of today (Barcelona, Spain : 1998), 2009, Volume: 45, Issue:8 Topics: Acetamides; Animals; Antidepressive Agents; Anxiety; Depressive Disorder, Major; Drug Interactions;	2009
Therapeutic perspectives for melatonin agonists and antagonists. Journal of neuroendocrinology, 2003, Volume: 15, Issue:4 Topics: Animals; Anxiety; Body Weight; Brain; Cerebrovascular Circulation; Chronobiology Disorders; Circadia	2003
[Premenstrual dysphoric disorder: approach and treatment]. Gynecologie, obstetrique & fertilite, 2003, Volume: 31, Issue:1 Topics: Affect; Anxiety; Depression; Female; Humans; Luteal Phase; Melatonin; Premenstrual Syndrome; Selecti	2003
The trajectory of biomarkers in symptom management for older adults with cancer. Seminars in oncology nursing, 2006, Volume: 22, Issue:1 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aged; Aging; Anxiety; Biomarkers; Biomarkers, Tumor; Cy	2006
[Sleep in fibromyalgia: review of clinical and polysomnographic data]. Neurophysiologie clinique = Clinical neurophysiology, 2001, Volume: 31, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib	2001
[Sleep in fibromyalgia: review of clinical and polysomnographic data]. Neurophysiologie clinique = Clinical neurophysiology, 2001, Volume: 31, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib	2001
[Sleep in fibromyalgia: review of clinical and polysomnographic data]. Neurophysiologie clinique = Clinical neurophysiology, 2001, Volume: 31, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib	2001
[Sleep in fibromyalgia: review of clinical and polysomnographic data]. Neurophysiologie clinique = Clinical neurophysiology, 2001, Volume: 31, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib	2001

Article	Year
Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. Acta anaesthesiologica Scandinavica, 2022, Volume: 66, Issue:9 Topics: Analgesics; Anti-Anxiety Agents; Anxiety; Herniorrhaphy; Humans; Melatonin; Pain	2022
The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2023, Volume: 38, Issue:2 Topics: Analgesia; Anesthesia, Local; Anxiety; Cataract; Double-Blind Method; Humans; Intraocular Pressure;	2023
Efficacy and Safety of Anxiolytics in Mohs Micrographic Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2023, 11-01, Volume: 49, Issue:11 Topics: Alprazolam; Anti-Anxiety Agents; Anxiety; Diazepam; Double-Blind Method; Gabapentin; Humans; Lorazep	2023
The effect of melatonin on depressive symptoms and anxiety in patients after acute coronary syndrome: The MEDACIS randomized clinical trial. Journal of psychiatric research, 2019, Volume: 119 Topics: Acute Coronary Syndrome; Aged; Antidepressive Agents; Anxiety; Depression; Depressive Disorder, Majo	2019
Premedication with melatonin vs midazolam: efficacy on anxiety and compliance in paediatric surgical patients. European journal of pediatrics, 2017, Volume: 176, Issue:7 Topics: Administration, Oral; Adolescent; Anesthesia, Intravenous; Anti-Anxiety Agents; Anxiety; Child; Doub	2017
Efficacy of melatonin for sleep disturbance following traumatic brain injury: a randomised controlled trial. BMC medicine, 2018, 01-19, Volume: 16, Issue:1 Topics: Actigraphy; Adult; Anxiety; Australia; Brain Injuries, Traumatic; Cross-Over Studies; Double-Blind M	2018
Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial. The Annals of pharmacotherapy, 2018, Volume: 52, Issue:10 Topics: Aged; Anxiety; Combined Modality Therapy; Female; Humans; Iran; Male; Melatonin; Middle Aged; Oxazep	2018
The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment. Addiction biology, 2019, Volume: 24, Issue:4 Topics: Adult; Analgesics, Opioid; Antioxidants; Anxiety; Blood Glucose; C-Reactive Protein; Cholesterol, HD	2019
Should Melatonin Be Used as an Alternative Sedative and Anxiolytic Agent in Mandibular Third Molar Surgery? Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2019, Volume: 77, Issue:9 Topics: Anti-Anxiety Agents; Anxiety; Double-Blind Method; Humans; Hypnotics and Sedatives; Melatonin; Molar	2019
Efficacy of the novel antidepressant agomelatine for anxiety symptoms in major depression. Human psychopharmacology, 2013, Volume: 28, Issue:2 Topics: Acetamides; Adult; Antidepressive Agents; Anxiety; Depressive Disorder, Major; Double-Blind Method;	2013
The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. Indian journal of ophthalmology, 2013, Volume: 61, Issue:7 Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anxiety; Central Nerv	2013
Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial. Breast cancer research and treatment, 2014, Volume: 145, Issue:3 Topics: Adult; Aged; Antidepressive Agents; Anxiety; Breast Neoplasms; Central Nervous System Depressants; D	2014
Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled-infusions. Journal of clinical pharmacology, 2015, Volume: 55, Issue:3 Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Anesthetics, Intravenous; A	2015
A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. PloS one, 2013, Volume: 8, Issue:10 Topics: Administration, Sublingual; Adult; Analgesics; Anxiety; Brazil; Depression; Dose-Response Relationsh	2013
Melatonin versus midazolam premedication in children undergoing surgery: A pilot study. Journal of paediatrics and child health, 2016, Volume: 52, Issue:3 Topics: Adolescent; Anesthesia Recovery Period; Anesthetics, Intravenous; Anxiety; Child; Child, Preschool;	2016
Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2015, Volume: 66, Issue:5 Topics: Affect; Aged; Anxiety; Appetite; Body Mass Index; Depression; Double-Blind Method; Drug Therapy, Com	2015
Melatonin premedication versus placebo in wisdom teeth extraction: a randomised controlled trial. Singapore medical journal, 2015, Volume: 56, Issue:12 Topics: Adult; Aged; Anxiety; Female; Humans; Male; Melatonin; Middle Aged; Molar, Third; Pain Measurement;	2015
Melatonin improves memory acquisition under stress independent of stress hormone release. Psychopharmacology, 2009, Volume: 202, Issue:4 Topics: Adult; Affect; Antioxidants; Anxiety; Attention; Catecholamines; Double-Blind Method; Epinephrine; E	2009
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. The journal of pain, 2009, Volume: 10, Issue:1 Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central	2009
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. The journal of pain, 2009, Volume: 10, Issue:1 Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central	2009
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. The journal of pain, 2009, Volume: 10, Issue:1 Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central	2009
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. The journal of pain, 2009, Volume: 10, Issue:1 Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central	2009
Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. Aging clinical and experimental research, 2009, Volume: 21, Issue:1 Topics: Aged; Aged, 80 and over; Anxiety; Behavioral Symptoms; Cross-Over Studies; Depression; Double-Blind	2009
Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Analgesics; Anesthetics, Loc	2009
Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. Anesthesiology, 2009, Volume: 111, Issue:1 Topics: Adult; Anesthesia; Anesthesia Recovery Period; Anxiety; Child; Child, Preschool; Female; Follow-Up S	2009
[Complex estimation of the psychotropic activity spectrum of pineal hormone melatonin in young healthy humans]. Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:10 Topics: Adult; Anxiety; Central Nervous System Depressants; Depression; Female; Humans; Male; Melatonin; Mem	2012
Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report. The Journal of neuropsychiatry and clinical neurosciences, 2004,Winter, Volume: 16, Issue:1 Topics: Acupuncture; Adolescent; Adult; Anxiety; Circadian Rhythm; Cross-Over Studies; Female; Humans; Male;	2004
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. European journal of anaesthesiology, 2005, Volume: 22, Issue:3 Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio	2005
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. European journal of anaesthesiology, 2005, Volume: 22, Issue:3 Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio	2005
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. European journal of anaesthesiology, 2005, Volume: 22, Issue:3 Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio	2005
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. European journal of anaesthesiology, 2005, Volume: 22, Issue:3 Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio	2005
Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Alimentary pharmacology & therapeutics, 2005, Nov-15, Volume: 22, Issue:10 Topics: Adult; Aged; Anxiety; Depressive Disorder; Double-Blind Method; Female; Gastrointestinal Agents; Hum	2005
Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery. Anesthesia and analgesia, 2006, Volume: 103, Issue:1 Topics: Aged; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Male; Melatonin; Preanesthe	2006
Is there any difference in the effects of Qi therapy (external Qigong) with and without touching? A pilot study. The International journal of neuroscience, 2006, Volume: 116, Issue:9 Topics: Adult; Affect; Anxiety; Breathing Exercises; Humans; Hydrocortisone; Immune System; Killer Cells, Na	2006
Melatonin premedication and the induction dose of propofol. European journal of anaesthesiology, 2007, Volume: 24, Issue:5 Topics: Adolescent; Adult; Antioxidants; Anxiety; Blood Pressure; Dose-Response Relationship, Drug; Drug Syn	2007
Evaluation of anxiety, salivary cortisol and melatonin secretion following reflexology treatment: a pilot study in healthy individuals. Complementary therapies in clinical practice, 2007, Volume: 13, Issue:3 Topics: Adolescent; Adult; Anxiety; Biometry; Blood Pressure; Cross-Over Studies; Heart Rate; Humans; Hydroc	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Administration, Oral; Adult; Anxiety; Circadian Rhythm; Double-Blind Method; Female; Humans; Hystere	2007
Premedication with melatonin: a double-blind, placebo-controlled comparison with midazolam. British journal of anaesthesia, 1999, Volume: 82, Issue:6 Topics: Administration, Sublingual; Adult; Anxiety; Chi-Square Distribution; Double-Blind Method; Evaluation	1999
The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study. Anesthesia and analgesia, 2000, Volume: 91, Issue:2 Topics: Adolescent; Adult; Anesthesia Recovery Period; Anxiety; Cognition; Conscious Sedation; Dose-Response	2000
The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study. Anesthesia and analgesia, 2000, Volume: 91, Issue:2 Topics: Adolescent; Adult; Anesthesia Recovery Period; Anxiety; Cognition; Conscious Sedation; Dose-Response	2000
The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study. Anesthesia and analgesia, 2000, Volume: 91, Issue:2 Topics: Adolescent; Adult; Anesthesia Recovery Period; Anxiety; Cognition; Conscious Sedation; Dose-Response	2000
The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study. Anesthesia and analgesia, 2000, Volume: 91, Issue:2 Topics: Adolescent; Adult; Anesthesia Recovery Period; Anxiety; Cognition; Conscious Sedation; Dose-Response	2000
Negative effects of melatonin on depression. The American journal of psychiatry, 1976, Volume: 133, Issue:10 Topics: Adult; Anger; Anxiety; Body Temperature; Body Weight; Calcium; Clinical Trials as Topic; Depression;	1976

Article	Year
Longitudinal Changes in Sleep, Biological Rhythms, and Light Exposure From Late Pregnancy to Postpartum and Their Impact on Peripartum Mood and Anxiety. The Journal of clinical psychiatry, 2022, 01-18, Volume: 83, Issue:2 Topics: Actigraphy; Adult; Affect; Anxiety; Circadian Rhythm; Depression, Postpartum; Female; Humans; Longit	2022
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022, Volume: 122, Issue:3 Topics: Adolescent; Adult; Aged; Alcoholism; Anhedonia; Antiphospholipid Syndrome; Anxiety; Comorbidity; Dep	2022
Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia. Scandinavian journal of clinical and laboratory investigation, 2023, Volume: 83, Issue:2 Topics: Anxiety; COVID-19; Depression; Humans; Melatonin; Sleep Initiation and Maintenance Disorders	2023
Postnatal melatonin administration to stressed dams for ameliorating risk-taking behaviour in rat pups through maternal care improvement. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2023, Volume: 83, Issue:4 Topics: Animals; Anxiety; Corticosterone; Female; Humans; Melatonin; Pregnancy; Prenatal Exposure Delayed Ef	2023
Repeated donkey milk consumption reduces anxiety-like behaviors and brain oxidative damage to lipids in mice. Behavioural brain research, 2023, 07-09, Volume: 449 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Brain Injuries; Depression; Lipids;	2023
Melatonin reverses depressive and anxiety like-behaviours induced by diabetes: involvement of oxidative stress, age, rage and S100B levels in the hippocampus and prefrontal cortex of rats. Archives of physiology and biochemistry, 2022, Volume: 128, Issue:2 Topics: Animals; Anxiety; Depression; Diabetes Mellitus, Experimental; Hippocampus; Malondialdehyde; Melaton	2022
Investigation on the influence of isolated environment on human psychological and physiological health. The Science of the total environment, 2020, May-10, Volume: 716 Topics: Anxiety; Circadian Rhythm; Environment; Humans; Hydrocortisone; Melatonin; Mental Health	2020
Chronic Exposure to Low Concentration Lead Chloride-Induced Anxiety and Loss of Aggression and Memory in Zebrafish. International journal of molecular sciences, 2020, Mar-07, Volume: 21, Issue:5 Topics: Aggression; Animals; Anxiety; Behavior, Animal; Ecotoxicology; Environmental Exposure; Hydrocortison	2020
Parent survey of sleep problems among children with CHARGE syndrome. Research in developmental disabilities, 2020, Volume: 101 Topics: Adolescent; Anxiety; Central Nervous System Depressants; CHARGE Syndrome; Child; Child, Preschool; C	2020
Adolescent social anxiety and clock disruption. A commentary. Journal of affective disorders, 2020, 05-15, Volume: 269 Topics: Adolescent; Anxiety; Circadian Rhythm; Depression; Humans; Melatonin; Sleep	2020
Melatonin Decreases Circulating Levels of Galectin-3 and Cytokines, Motor Activity, and Anxiety Following Acute Global Cerebral Ischemia in Male Rats. Archives of medical research, 2021, Volume: 52, Issue:5 Topics: Animals; Anxiety; Brain Ischemia; Cytokines; Galectin 3; Male; Melatonin; Motor Activity; Rats; Rats	2021
Rat models for low and high adaptive response to exercise differ for stress-related memory and anxiety. Physiological reports, 2021, Volume: 9, Issue:4 Topics: Adaptation, Physiological; Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Brain; C	2021
Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: Role of oxidative stress, neuroinflammation, autophagy and apoptosis. Brain research bulletin, 2021, Volume: 174 Topics: Animals; Antioxidants; Anxiety; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Calcium-Binding	2021
Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. Journal of autism and developmental disorders, 2017, Volume: 47, Issue:7 Topics: Adult; Anxiety; Autism Spectrum Disorder; Circadian Rhythm; Depression; Female; Humans; Male; Melato	2017
Melatonin ameliorates anxiety and depression-like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease. BioFactors (Oxford, England), 2017, Jul-08, Volume: 43, Issue:4 Topics: Alzheimer Disease; Animals; Anxiety; Depression; Disease Models, Animal; Glutathione Transferase; Hi	2017
The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices. Brain research bulletin, 2017, Volume: 134 Topics: Animals; Antidepressive Agents; Anxiety; Depression; Diabetes Mellitus, Experimental; Fluoxetine; Gl	2017
Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress. The International journal of neuroscience, 2018, Volume: 128, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Anxiety; Behavior, Animal; Depression; Lipopolysacc	2018
Antidepressant agomelatine attenuates behavioral deficits and concomitant pathology observed in streptozotocin-induced model of Alzheimer's disease in male rats. Hormones and behavior, 2019, Volume: 107 Topics: Acetamides; Alzheimer Disease; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Disease Mo	2019
Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. Physiology & behavior, 2019, 05-15, Volume: 204 Topics: Amyloid beta-Peptides; Animals; Anxiety; Carbazoles; Exploratory Behavior; Gene Dosage; Hippocampus;	2019
Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder? Journal of the American Academy of Child and Adolescent Psychiatry, 2019, Volume: 58, Issue:3 Topics: Adolescent; Antioxidants; Anxiety; Chronotherapy; Circadian Rhythm; Combined Modality Therapy; Depre	2019
Melatonin probably reduces anxiety in patients undergoing third-molar surgical extractions but maybe not as much as midazolam. Journal of the American Dental Association (1939), 2019, Volume: 150, Issue:10 Topics: Anti-Anxiety Agents; Anxiety; Humans; Hypnotics and Sedatives; Melatonin; Midazolam; Molar, Third; T	2019
Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat. Behavioural brain research, 2013, Sep-01, Volume: 252 Topics: Analysis of Variance; Animals; Anxiety; Body Weight; Cell Count; Chronobiology Disorders; Corticoste	2013
Effects of circadian phase and melatonin injection on anxiety-like behavior in nocturnal and diurnal rodents. Chronobiology international, 2013, Volume: 30, Issue:6 Topics: Animals; Anxiety; Biological Clocks; Central Nervous System Depressants; Circadian Rhythm; Gerbillin	2013
Effects of melatonin on behavioral changes of neonatal rats in a model of cortical dysplasia. European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:15 Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Cold Temperature; Malformations of Cortical De	2013
Melatonin protects against diazinon-induced neurobehavioral changes in rats. Neurochemical research, 2013, Volume: 38, Issue:10 Topics: Animals; Anxiety; Behavior, Animal; Brain Chemistry; Diazinon; Dopamine; Glutathione Peroxidase; Mal	2013
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Perioperative melatonin: not ready for prime time. British journal of anaesthesia, 2014, Volume: 112, Issue:1 Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep	2014
Melatonin treatment during early life interacts with restraint to alter neuronal morphology and provoke depressive-like responses. Behavioural brain research, 2014, Apr-15, Volume: 263 Topics: Anhedonia; Animals; Anxiety; CA1 Region, Hippocampal; Cricetinae; Dendrites; Depressive Disorder; Di	2014
[Poststroke cognitive, emotional impairment and sleep quality: efficience of treatment with melaxen]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2014, Volume: 114, Issue:4 Topics: Adult; Aged; Anxiety; Cognition; Cognition Disorders; Emotions; Female; Humans; Male; Melatonin; Mid	2014
Genetic deletion of MT₁/MT₂ melatonin receptors enhances murine cognitive and motor performance. Neuroscience, 2014, Sep-26, Volume: 277 Topics: Animals; Anxiety; Circadian Rhythm; CREB-Binding Protein; Drinking; Frontal Lobe; Hippocampus; Locom	2014
Differential neuromodulatory role of NO in anxiety and seizures: an experimental study. Nitric oxide : biology and chemistry, 2014, Dec-01, Volume: 43 Topics: Aminophylline; Animals; Anxiety; Arginine; Enzyme Inhibitors; Male; Malondialdehyde; Melatonin; Neur	2014
Buspirone along with melatonin attenuates oxidative damage and anxiety-like behavior in a mouse model of immobilization stress. Chinese journal of natural medicines, 2014, Volume: 12, Issue:8 Topics: Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Behavior, Animal; Buspirone; Immobilization; Ma	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Chronobiology, cognitive function and depressive symptoms in surgical patients. Danish medical journal, 2014, Volume: 61, Issue:9 Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep	2014
Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice. Hormones and behavior, 2014, Volume: 66, Issue:4 Topics: Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Depression; Female; Male; Melatonin; Mice; Mic	2014
[An effect of valdoxan on the hemostasis in patients with acute coronary syndrome in the combination with anxiety and depressive disorders]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:2 Topics: Acetamides; Acute Coronary Syndrome; Adult; Aged; Anxiety; Central Nervous System Depressants; Depre	2015
Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. Molecular neurodegeneration, 2015, Jul-11, Volume: 10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anxiety; Disease	2015
Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin. Scientific reports, 2015, Oct-01, Volume: 5 Topics: Animals; Anxiety; Brain; Caspase 3; Cognition Disorders; Drug Evaluation, Preclinical; Glial Fibrill	2015
Milk Collected at Night Induces Sedative and Anxiolytic-Like Effects and Augments Pentobarbital-Induced Sleeping Behavior in Mice. Journal of medicinal food, 2015, Volume: 18, Issue:11 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cattle; Circadian Rhythm; Hypnotics and Sed	2015
Effects of environmental stress on the depression-like behaviors and the diurnal rhythm of corticosterone and melatonin in male rats. Sheng li xue bao : [Acta physiologica Sinica], 2016, Jun-25, Volume: 68, Issue:3 Topics: Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Corticosterone; Depression; Depressive Disorde	2016
Behavioral and molecular effects of prenatal continuous light exposure in the adult rat. Brain research, 2016, 11-01, Volume: 1650 Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain; Circadian Rhythm; Female; Light; Male;	2016
Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment. Folia biologica, 2016, Volume: 62, Issue:6 Topics: Animals; Anxiety; Chronic Disease; Dopamine; Gene Expression Regulation, Enzymologic; Grooming; Hipp	2016
The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial. Trials, 2017, 02-23, Volume: 18, Issue:1 Topics: Acute Coronary Syndrome; Anxiety; Circadian Rhythm; Clinical Protocols; Depression; Double-Blind Met	2017
We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:1 Topics: Aggression; Animals; Anxiety; Body Weight; Data Interpretation, Statistical; Depression; Food Prefer	2009
All results count. Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Analgesics; Anti-Anxiety Agents; Anxiety; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives;	2009
Effects of bright light treatment on depression- and anxiety-like behaviors of diurnal rodents maintained on a short daylight schedule. Behavioural brain research, 2009, Aug-12, Volume: 201, Issue:2 Topics: Affect; Analysis of Variance; Animals; Anxiety; Circadian Rhythm; Depression; Disease Models, Animal	2009
Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:4 Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Fem	2009
Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams. European journal of pain (London, England), 2010, Volume: 14, Issue:10 Topics: Animals; Animals, Newborn; Antigens, Bacterial; Anxiety; Arthritis, Experimental; Behavior, Animal;	2010
Sleep disturbance and melatonin levels following traumatic brain injury. Neurology, 2010, May-25, Volume: 74, Issue:21 Topics: Adult; Anxiety; Area Under Curve; Brain Injuries; Case-Control Studies; Depression; Electroencephalo	2010
Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2010, Volume: 43, Issue:9 Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Circadian Rhythm; Female; Hydro-Lyases; Malate	2010
The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. Behavioural brain research, 2011, Sep-12, Volume: 222, Issue:1 Topics: Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Ani	2011
Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behavior modification and oxidative damage in mice. Indian journal of experimental biology, 2011, Volume: 49, Issue:3 Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Flumazenil; GABA Modulators; gamma-Aminobutyric Ac	2011
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jul-12, Volume: 108, Issue:28 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Basal Nucleus of Meynert	2011
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. Progress in neuro-psychopharmacology & biological psychiatry, 2012, Dec-03, Volume: 39, Issue:2 Topics: Acetamides; Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Anim	2012
Behavioural actions of two new 1-N substituted analogues of melatonin. Behavioural brain research, 2013, Jan-01, Volume: 236, Issue:1 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antioxidants; Anxiety; Behavior, Animal; Diazepam; Do	2013
Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment. Brain research, 2002, Nov-29, Volume: 956, Issue:2 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cocaine; Cyclic AMP; Dopamine Uptake Inhibi	2002
Melatonin MT(1/2) receptor stimulation reduces cortical overflow of cholecystokinin-like material in a model of anticipation of social defeat in the rat. Neuropharmacology, 2004, Volume: 46, Issue:8 Topics: Animals; Anxiety; Cerebral Cortex; Cholecystokinin; Dominance-Subordination; Heterocyclic Compounds,	2004
Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade. Psychopharmacology, 2005, Volume: 177, Issue:4 Topics: Acetamides; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain Chemistry; Clorazepa	2005
ICV melatonin reduces acute stress responses in neonatal chicks. Behavioural brain research, 2005, Dec-07, Volume: 165, Issue:2 Topics: Analysis of Variance; Animal Husbandry; Animals; Animals, Newborn; Anxiety; Brain Chemistry; Brain S	2005
Effects of melatonin and agomelatine in anxiety-related procedures in rats: interaction with diazepam. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:6 Topics: Acetamides; Animals; Anxiety; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Dru	2006
Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls. Journal of behavioral medicine, 2007, Volume: 30, Issue:1 Topics: Adult; Anxiety; Breast Neoplasms; Catecholamines; Depression; Female; Health Status; Humans; Hydroco	2007
Effect of melatonin on exploration and anxiety in normotensive and hypertensive rats with high activity of renin-angiotensin system. Neuro endocrinology letters, 2007, Volume: 28, Issue:3 Topics: Animals; Anxiety; Exploratory Behavior; Hypertension; Male; Maze Learning; Melatonin; Motor Activity	2007
Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice. Journal of pineal research, 2008, Volume: 45, Issue:2 Topics: Animals; Antioxidants; Anxiety; Brain Ischemia; Cell Survival; Doublecortin Domain Proteins; Hyperki	2008
[The effect of melatonin on the anxiety-phobic behavioral characteristics of intact and epiphysectomized rats]. Fiziologicheskii zhurnal imeni I.M. Sechenova, 1996, Volume: 82, Issue:4 Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Male; Melatonin; Phobic Disord	1996
Effects of melatonin on neophobic responses in different strains of mice. Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:4 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Exploratory Behavior; Flumazenil; GABA Modu	1999
Antagonistic effects of S 22153, a new mt1 and MT2 receptor ligand, on the neophobia-reducing properties of melatonin in BALB/c mice. Pharmacology, biochemistry, and behavior, 1999, Volume: 64, Issue:1 Topics: Animals; Anti-Anxiety Agents; Anxiety; Dose-Response Relationship, Drug; Exploratory Behavior; Ligan	1999
Psychobiological markers of stress in pregnancy: 6-sulfatoxymelatonin--a longitudinal study. American journal of perinatology, 1999, Volume: 16, Issue:5 Topics: Adult; Anxiety; Biomarkers; Female; Gestational Age; Humans; Hydrocortisone; Melatonin; Pregnancy; P	1999
Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. Pharmacology, 2001, Volume: 62, Issue:3 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Dose-Res	2001
Melatonin reduces anxiety induced by lipopolysaccharide in the rat. Neuroscience letters, 2001, Jul-06, Volume: 307, Issue:1 Topics: Animals; Anxiety; Bacterial Infections; Behavior, Animal; Brain; Circadian Rhythm; Dose-Response Rel	2001
Hypothalamic involvement in chronic migraine. Journal of neurology, neurosurgery, and psychiatry, 2001, Volume: 71, Issue:6 Topics: Adult; Anxiety; Case-Control Studies; Chronic Disease; Chronobiology Disorders; Circadian Rhythm; Co	2001

melatonin and Anxiety