melatonin has been researched along with Anoxia-Ischemia, Brain in 56 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of adding melatonin to hypothermia treatment on neurodevelopmental outcomes in asphyctic newborns." | 9.34 | Hypothermia Plus Melatonin in Asphyctic Newborns: A Randomized-Controlled Pilot Study. ( Benitez-Feliponi, Á; Fernández-Marín, CE; Jerez-Calero, A; Muñoz-Hoyos, A; Narbona-López, E; Salvatierra-Cuenca, MT; Uberos-Fernández, J, 2020) |
| "These findings provide substantial evidence that melatonin treatment has protective effects on the brain and peripheral organs after HIBD, and the edema related proteins, AQP4, ZO-1, and occludin, may indirectly contribute tothe mechanism of the edema protection by melatonin." | 7.85 | Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. ( Ding, X; Feng, X; Han, X; Li, YH; Liu, MH; Lv, Y; Sun, B; Wang, Y; Xu, LX, 2017) |
| "Melatonin is a natural neuroprotective hormone, which makes it promising for the treatment of neurodegeneration after asphyxia." | 7.01 | Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia. ( Furmaga-Jabłońska, W; Januszewski, S; Pluta, R; Tarkowska, A, 2023) |
| "Melatonin (15 mg/kg) was administered 5 min after HI." | 5.91 | MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Dell'Orto, V; Perrone, S; Vanzolini, T; Weiss, MD, 2023) |
| "To investigate the effect of adding melatonin to hypothermia treatment on neurodevelopmental outcomes in asphyctic newborns." | 5.34 | Hypothermia Plus Melatonin in Asphyctic Newborns: A Randomized-Controlled Pilot Study. ( Benitez-Feliponi, Á; Fernández-Marín, CE; Jerez-Calero, A; Muñoz-Hoyos, A; Narbona-López, E; Salvatierra-Cuenca, MT; Uberos-Fernández, J, 2020) |
| " Melatonin is a hormone with antioxidant and anti-inflammatory effects that make it a promising molecule for the treatment of perinatal asphyxia." | 5.22 | Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy. ( Cannavò, L; D'angelo, G; Gitto, E; Reiter, RJ, 2022) |
| "These findings provide substantial evidence that melatonin treatment has protective effects on the brain and peripheral organs after HIBD, and the edema related proteins, AQP4, ZO-1, and occludin, may indirectly contribute tothe mechanism of the edema protection by melatonin." | 3.85 | Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. ( Ding, X; Feng, X; Han, X; Li, YH; Liu, MH; Lv, Y; Sun, B; Wang, Y; Xu, LX, 2017) |
| "Melatonin is a natural neuroprotective hormone, which makes it promising for the treatment of neurodegeneration after asphyxia." | 3.01 | Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia. ( Furmaga-Jabłońska, W; Januszewski, S; Pluta, R; Tarkowska, A, 2023) |
| "Melatonin is an indole endocrine hormone mainly produced by the pineal gland and it has the ability to easily penetrate the blood-brain barrier." | 3.01 | [Research research on the use of melatonin in combination with therapeutic hypothermia for the treatment of neonatal hypoxic-ischemic encephalopathy]. ( Liu, YX; Xia, SW, 2023) |
| "Melatonin half-life and clearance were prolonged, and the distribution volume decreased compared to adults." | 2.90 | Melatonin pharmacokinetics and dose extrapolation after enteral infusion in neonates subjected to hypothermia. ( Balduini, W; Bazzini, F; Buonocore, G; Carloni, S; Longini, M; Ott, D; Perrone, S; Rocchi, M; Rossignol, C; Sura, L; Wadhawan, R; Weiss, MD, 2019) |
| "Melatonin has been shown to be neuroprotective in animal models." | 2.80 | Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. ( Aly, H; Awny, M; El-Dib, M; El-Gohary, T; El-Mashad, AR; Elbatch, M; Elmahdy, H; Hamisa, M; Rowisha, M, 2015) |
| "Melatonin has shown neuroprotective properties in pre-clinical studies of perinatal asphyxia through antioxidant, anti-apoptotic and anti-inflammatory actions." | 2.72 | Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials. ( Ahmed, J; More, K; Pullattayil S, AK; Robertson, NJ, 2021) |
| " Challenges include timing, dosing and administration route for each neuroprotectant." | 2.61 | Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia. ( Cheung, PY; Schmölzer, GM; Solevåg, AL, 2019) |
| "Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect." | 2.48 | Melatonin utility in neonates and children. ( Chen, YC; Huang, LT; Sheen, JM; Tain, YL, 2012) |
| "Melatonin (15 mg/kg) was administered 5 min after HI." | 1.91 | MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Dell'Orto, V; Perrone, S; Vanzolini, T; Weiss, MD, 2023) |
| "Melatonin treatment has benefitted neonates with hypoxic-ischemic (HI) brain injury." | 1.72 | Human-rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic-ischemic pathway melatonin-sensitive. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Coppari, S; Longini, M; Melandri, D; Mohammadi, A; Negrini, M; Perrone, S; Rocchi, MBL; Sura, L; Vanzolini, T; Weiss, MD, 2022) |
| "Melatonin can inhibit the hyperactivity of NLRP3 inflammasomes by enhancing mitochondrial autophagy and inhibiting TLR4/NF-κB pathway activity." | 1.62 | Protective effects of melatonin on the white matter damage of neonatal rats by regulating NLRP3 inflammasome activity. ( Jiang, H; Li, X; Liu, Y; Qin, M; Sun, M; Xu, J; Zhang, L, 2021) |
| "Melatonin (Mel) has neuroprotective effects; however, its roles in hypoxic-ischemic brain damage (HIBD) and the underlying mechanisms remain unknown." | 1.56 | Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway. ( Fan, Y; Gou, Z; Hu, X; Huang, L; Li, J; Lu, L; Su, X; Zhou, Y, 2020) |
| "Melatonin has potential neuroprotective capabilities after neonatal hypoxia-ischemia (HI), but long-term effects have not been investigated." | 1.51 | Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats. ( Berger, HR; Morken, TS; Nyman, AKG; Widerøe, M, 2019) |
| " This information, coupled with pharmacokinetic data, will help to define the therapeutic dosage of melatonin in vivo and, ultimately, in patients." | 1.48 | Melatonin Acts in Synergy with Hypothermia to Reduce Oxygen-Glucose Deprivation-Induced Cell Death in Rat Hippocampus Organotypic Slice Cultures. ( Balduini, W; Buonocore, G; Carloni, S; Facchinetti, F; Pelizzi, N, 2018) |
| "Melatonin treatment also significantly increased the GAP43 in the cortex." | 1.46 | Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: An in vivo and in vitro investigation in experimental models of neonatal HI brain injury. ( Fang, M; Hu, Y; Jiang, H; Li, Z; Lin, Z; Liu, Y; Pan, S; Wang, Z; Xiao, J; Yin, J; Zhang, H; Zou, S, 2017) |
| "Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury." | 1.46 | Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo1H MR spectroscopy. ( Berger, HR; Brubakk, AM; Morken, TS; Nyman, AKG; Vettukattil, R; Widerøe, M, 2017) |
| "Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions against hypoxic-ischaemic brain injury in animal models." | 1.39 | Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. ( Andorka, C; Bainbridge, A; Cady, EB; Chandrasekaran, M; Faulkner, S; Fleiss, B; Golay, X; Gressens, P; Hristova, M; Lecky-Thompson, L; Powell, E; Price, D; Raivich, G; Robertson, NJ; Thei, L, 2013) |
| "Melatonin also reduced reactive gliosis." | 1.38 | Histological study of the protective effect of melatonin on neural cells after neonatal hypoxia-ischemia. ( Alonso-Alconada, D; Alvarez, A; Hilario, E; Lacalle, J, 2012) |
| "Melatonin treatment reduced VEGF and NO levels as well as leakage of HRP suggesting its potential value in ameliorating damage in choroid plexus pathologies." | 1.35 | Vascular endothelial growth factor and nitric oxide production in response to hypoxia in the choroid plexus in neonatal brain. ( Kaur, C; Ling, EA; Lu, J; Sivakumar, V, 2008) |
| "Melatonin is a powerful scavenger of the oxygen free radicals." | 1.33 | The protective role of melatonin in experimental hypoxic brain damage. ( Ayvaz, S; Başaran, UN; Ekuklu, G; Eskiocak, S; Tütüncüler, F; Vatansever, U, 2005) |
| "Melatonin, which plays an important role in circadian rhythm regulation, is highly potent endogenous free radical scavenger and antioxidant." | 1.32 | Neuroprotective effects of melatonin against anoxia/aglycemia stress, as assessed by synaptic potentials and superoxide production in rat hippocampal slices. ( Fukuda, A; Okabe, A; Samejima, M; Uchida, K, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (12.50) | 29.6817 |
| 2010's | 32 (57.14) | 24.3611 |
| 2020's | 17 (30.36) | 2.80 |
| Authors | Studies |
|---|---|
| Victor, S | 1 |
| Rocha-Ferreira, E | 1 |
| Rahim, A | 1 |
| Hagberg, H | 1 |
| Edwards, D | 1 |
| Weiss, MD | 3 |
| Carloni, S | 7 |
| Vanzolini, T | 2 |
| Coppari, S | 1 |
| Balduini, W | 7 |
| Buonocore, G | 7 |
| Longini, M | 4 |
| Perrone, S | 5 |
| Sura, L | 2 |
| Mohammadi, A | 1 |
| Rocchi, MBL | 1 |
| Negrini, M | 1 |
| Melandri, D | 1 |
| Albertini, MC | 3 |
| Zhang, Y | 1 |
| Chen, D | 1 |
| Wang, Y | 2 |
| Wang, X | 2 |
| Zhang, Z | 1 |
| Xin, Y | 1 |
| Pluta, R | 1 |
| Furmaga-Jabłońska, W | 1 |
| Januszewski, S | 1 |
| Tarkowska, A | 1 |
| Sabir, H | 1 |
| Maes, E | 1 |
| Zweyer, M | 1 |
| Schleehuber, Y | 1 |
| Imam, FB | 1 |
| Silverman, J | 1 |
| White, Y | 1 |
| Pang, R | 1 |
| Pasca, AM | 1 |
| Robertson, NJ | 5 |
| Maltepe, E | 1 |
| Bernis, ME | 1 |
| Liu, YX | 1 |
| Xia, SW | 1 |
| Dell'Orto, V | 1 |
| Chen, W | 2 |
| Chen, LF | 1 |
| Zhang, MB | 1 |
| Xia, YP | 1 |
| Zhao, YH | 1 |
| Li, GZ | 1 |
| Wang, XL | 1 |
| El Farargy, MS | 1 |
| Soliman, NA | 1 |
| Martini, S | 1 |
| Austin, T | 1 |
| Aceti, A | 1 |
| Faldella, G | 1 |
| Corvaglia, L | 1 |
| Berger, HR | 2 |
| Nyman, AKG | 3 |
| Morken, TS | 2 |
| Widerøe, M | 3 |
| Jerez-Calero, A | 1 |
| Salvatierra-Cuenca, MT | 1 |
| Benitez-Feliponi, Á | 1 |
| Fernández-Marín, CE | 1 |
| Narbona-López, E | 1 |
| Uberos-Fernández, J | 1 |
| Muñoz-Hoyos, A | 1 |
| Molska, A | 1 |
| Sofias, AM | 1 |
| Kristiansen, KA | 1 |
| Hak, S | 1 |
| Gou, Z | 1 |
| Su, X | 1 |
| Hu, X | 1 |
| Zhou, Y | 1 |
| Huang, L | 1 |
| Fan, Y | 1 |
| Li, J | 1 |
| Lu, L | 1 |
| D'angelo, G | 1 |
| Cannavò, L | 1 |
| Reiter, RJ | 2 |
| Gitto, E | 1 |
| Frajewicki, A | 1 |
| Laštůvka, Z | 1 |
| Borbélyová, V | 1 |
| Khan, S | 1 |
| Jandová, K | 1 |
| Janišová, K | 1 |
| Otáhal, J | 1 |
| Mysliveček, J | 1 |
| Riljak, V | 1 |
| Ahmed, J | 1 |
| Pullattayil S, AK | 1 |
| More, K | 1 |
| Qin, M | 1 |
| Liu, Y | 2 |
| Sun, M | 1 |
| Li, X | 1 |
| Xu, J | 1 |
| Zhang, L | 1 |
| Jiang, H | 2 |
| Aridas, JD | 1 |
| Yawno, T | 2 |
| Sutherland, AE | 1 |
| Nitsos, I | 1 |
| Wong, FY | 1 |
| Hunt, RW | 1 |
| Ditchfield, M | 1 |
| Fahey, MC | 1 |
| Malhotra, A | 1 |
| Wallace, EM | 2 |
| Gunn, AJ | 1 |
| Jenkin, G | 2 |
| Miller, SL | 2 |
| Youssef, MI | 1 |
| Ma, J | 1 |
| Chen, Z | 1 |
| Hu, WW | 1 |
| Hu, Y | 1 |
| Wang, Z | 1 |
| Pan, S | 1 |
| Zhang, H | 2 |
| Fang, M | 1 |
| Yin, J | 1 |
| Zou, S | 1 |
| Li, Z | 1 |
| Lin, Z | 1 |
| Xiao, J | 1 |
| Xu, LX | 1 |
| Lv, Y | 1 |
| Li, YH | 1 |
| Ding, X | 1 |
| Han, X | 1 |
| Liu, MH | 1 |
| Sun, B | 2 |
| Feng, X | 2 |
| Castillo-Melendez, M | 1 |
| Sutherland, A | 1 |
| Sinha, B | 1 |
| Wu, Q | 1 |
| Li, W | 1 |
| Tu, Y | 1 |
| Sirianni, AC | 1 |
| Chen, Y | 1 |
| Jiang, J | 1 |
| Zhang, X | 1 |
| Zhou, S | 1 |
| Manning, SM | 1 |
| Patel, NJ | 1 |
| Aziz-Sultan, AM | 1 |
| Inder, TE | 1 |
| Friedlander, RM | 1 |
| Fu, J | 1 |
| Vettukattil, R | 1 |
| Brubakk, AM | 1 |
| Ahmad, QM | 1 |
| Chishti, AL | 1 |
| Waseem, N | 1 |
| Facchinetti, F | 2 |
| Pelizzi, N | 2 |
| Martinello, K | 1 |
| Lingam, I | 1 |
| Avdic-Belltheus, A | 1 |
| Meehan, C | 1 |
| Alonso-Alconada, D | 4 |
| Ragab, S | 1 |
| Bainbridge, A | 2 |
| Sokolska, M | 1 |
| Tachrount, M | 1 |
| Middleton, B | 1 |
| Price, D | 2 |
| Hristova, M | 2 |
| Golay, X | 2 |
| Soliani Raschini, A | 1 |
| Aquino, G | 1 |
| Paprocka, J | 1 |
| Kijonka, M | 1 |
| Borys, D | 1 |
| Emich-Widera, E | 1 |
| Wojcieszek, P | 1 |
| Sokół, M | 1 |
| Rocchi, M | 1 |
| Rossignol, C | 1 |
| Bazzini, F | 1 |
| Ott, D | 1 |
| Wadhawan, R | 1 |
| Albrecht, M | 1 |
| Zitta, K | 1 |
| Groenendaal, F | 1 |
| van Bel, F | 1 |
| Peeters-Scholte, C | 1 |
| McNally, MA | 1 |
| Soul, JS | 1 |
| Solevåg, AL | 1 |
| Schmölzer, GM | 1 |
| Cheung, PY | 1 |
| Alvarez, A | 3 |
| Arteaga, O | 2 |
| Martínez-Ibargüen, A | 2 |
| Hilario, E | 3 |
| Juul, SE | 2 |
| Ferriero, DM | 2 |
| Galluzzi, L | 1 |
| Proietti, F | 3 |
| Aly, H | 1 |
| Elmahdy, H | 1 |
| El-Dib, M | 1 |
| Rowisha, M | 1 |
| Awny, M | 1 |
| El-Gohary, T | 1 |
| Elbatch, M | 1 |
| Hamisa, M | 1 |
| El-Mashad, AR | 1 |
| Revuelta, M | 1 |
| Montalvo, H | 1 |
| Hassell, KJ | 1 |
| Ezzati, M | 1 |
| Hausenloy, DJ | 1 |
| McAdams, RM | 1 |
| Blanco, S | 1 |
| Hernández, R | 1 |
| Franchelli, G | 1 |
| Ramos-Álvarez, MM | 1 |
| Peinado, MÁ | 1 |
| Koh, PO | 1 |
| Hutton, LC | 1 |
| Abbass, M | 1 |
| Dickinson, H | 1 |
| Ireland, Z | 1 |
| Walker, DW | 1 |
| Cilio, MR | 1 |
| Levene, MI | 1 |
| Cetinkaya, M | 2 |
| Alkan, T | 2 |
| Ozyener, F | 2 |
| Kafa, IM | 2 |
| Kurt, MA | 2 |
| Koksal, N | 2 |
| Bertrando, S | 1 |
| Tataranno, ML | 1 |
| Negro, S | 1 |
| Chen, YC | 1 |
| Tain, YL | 1 |
| Sheen, JM | 1 |
| Huang, LT | 1 |
| Lacalle, J | 1 |
| Gören, B | 1 |
| Faulkner, S | 1 |
| Fleiss, B | 1 |
| Andorka, C | 1 |
| Powell, E | 1 |
| Lecky-Thompson, L | 1 |
| Thei, L | 1 |
| Chandrasekaran, M | 1 |
| Cady, EB | 1 |
| Gressens, P | 1 |
| Raivich, G | 1 |
| Uchida, K | 1 |
| Samejima, M | 1 |
| Okabe, A | 1 |
| Fukuda, A | 1 |
| Tütüncüler, F | 1 |
| Eskiocak, S | 1 |
| Başaran, UN | 1 |
| Ekuklu, G | 1 |
| Ayvaz, S | 1 |
| Vatansever, U | 1 |
| Yang, ZM | 1 |
| Sivakumar, V | 1 |
| Lu, J | 1 |
| Ling, EA | 1 |
| Kaur, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Melatonin for Neuroprotection in Term Infants With Hypoxic-ischaemic Encephalopathy[NCT03806816] | 100 participants (Anticipated) | Interventional | 2018-12-13 | Recruiting | |||
| Autophagy, Mitophagy, Inflammation and Plasmatic Concentration of Melatonin in Newborn With Metabolic Acidosis at Birth[NCT03897101] | 150 participants (Anticipated) | Observational [Patient Registry] | 2019-03-01 | Recruiting | |||
| A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia Plus Magnesium Sulphate (MgSO4) Versus Therapeutic Hypothermia Plus Placebo in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy[NCT01646619] | Phase 3 | 300 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | ||
| Melatonin for Neuroprotection Following Perinatal Asphyxia[NCT02071160] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 reviews available for melatonin and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy.
Topics: Animals; Humans; Hyperplasia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Melatonin; Neuroprotect | 2022 |
Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia.
Topics: Animals; Asphyxia; Asphyxia Neonatorum; Brain Injuries; Female; Humans; Hypothermia; Hypoxia-Ischemi | 2023 |
[Research research on the use of melatonin in combination with therapeutic hypothermia for the treatment of neonatal hypoxic-ischemic encephalopathy].
Topics: Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Intensive Care Units, Neonat | 2023 |
Free radicals and neonatal encephalopathy: mechanisms of injury, biomarkers, and antioxidant treatment perspectives.
Topics: Acetylcysteine; Allopurinol; Animals; Antioxidants; Asphyxia Neonatorum; Biomarkers; Brain Injuries; | 2020 |
Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy.
Topics: Asphyxia; Asphyxia Neonatorum; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant | 2022 |
Perinatal hypoxic-ischemic damage: review of the current treatment possibilities.
Topics: Central Nervous System Depressants; Erythropoietin; Female; Humans; Hypoxia; Hypoxia-Ischemia, Brain | 2020 |
Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials.
Topics: Asphyxia Neonatorum; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; | 2021 |
Potential therapeutic agents for ischemic white matter damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Edaravone; H | 2021 |
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.
Topics: Allopurinol; Asphyxia Neonatorum; Biotin; Cerebral Palsy; Clinical Trials as Topic; Epilepsy; Erythr | 2019 |
Pharmacologic Prevention and Treatment of Neonatal Brain Injury.
Topics: Adrenal Cortex Hormones; Allopurinol; Anesthetics, Inhalation; Anticonvulsants; Antioxidants; Cerebr | 2019 |
Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia.
Topics: Acetylcysteine; Allopurinol; Argon; Asphyxia Neonatorum; Cannabinoids; Erythropoietin; Female; Human | 2019 |
Neuroprotective effect of melatonin: a novel therapy against perinatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Apoptosis; Humans; Hypoxia-Ischemia, Brain; Inf | 2013 |
Pharmacologic neuroprotective strategies in neonatal brain injury.
Topics: Acetylcysteine; Allopurinol; Antioxidants; Ascorbic Acid; Biopterins; Erythropoietin; Excitatory Ami | 2014 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Topics: Asphyxia Neonatorum; Brain; Cannabinoids; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Isch | 2015 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; E | 2016 |
Synergistic neuroprotective therapies with hypothermia.
Topics: Acetylcysteine; Anticonvulsants; Body Temperature; Cannabinoids; Combined Modality Therapy; Erythrop | 2010 |
Melatonin utility in neonates and children.
Topics: Antioxidants; Child; Female; Fetal Growth Retardation; Humans; Hypoxia-Ischemia, Brain; Infant, Newb | 2012 |
6 trials available for melatonin and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
A randomized controlled trial on the use of magnesium sulfate and melatonin in neonatal hypoxic ischemic encephalopathy.
Topics: Asphyxia Neonatorum; Biomarkers; Electroencephalography; Female; Humans; Hypoxia-Ischemia, Brain; In | 2019 |
Hypothermia Plus Melatonin in Asphyctic Newborns: A Randomized-Controlled Pilot Study.
Topics: Humans; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Magneti | 2020 |
Role of melatonin in management of hypoxic ischaemic encephalopathy in newborns: A randomized control trial.
Topics: Birth Weight; Female; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, New | 2018 |
Melatonin pharmacokinetics and dose extrapolation after enteral infusion in neonates subjected to hypothermia.
Topics: Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Melatonin | 2019 |
Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study.
Topics: Asphyxia Neonatorum; Electroencephalography; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, | 2015 |
Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Brain Infarction; Caspase 3; Cell Count; Cel | 2012 |
33 other studies available for melatonin and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
Human-rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic-ischemic pathway melatonin-sensitive.
Topics: Animals; Animals, Newborn; Brain Injuries; Humans; Hypothermia; Hypoxia-Ischemia, Brain; Melatonin; | 2022 |
Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage.
Topics: Beclin-1; Brain; Glucose; Humans; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Leucine; Melato | 2023 |
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemas | 2023 |
MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia.
Topics: Animals; Animals, Newborn; Biomarkers; Brain; Brain Injuries; Female; Hypoxia-Ischemia, Brain; Ische | 2023 |
[Effects of different melatonin treatment regimens on the proliferation of endogenous neural stem cells in neonatal rats with hypoxic-ischemic brain damage].
Topics: Animals; Animals, Newborn; Brain; Cell Proliferation; Hypoxia-Ischemia, Brain; Melatonin; Neural Ste | 2019 |
Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats.
Topics: Animals; Animals, Newborn; Corpus Callosum; Diffusion Tensor Imaging; Female; Hypoxia-Ischemia, Brai | 2019 |
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
Topics: Animals; Animals, Newborn; Biological Availability; Brain; Chemistry, Pharmaceutical; Disease Models | 2020 |
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Topics: Animals; Animals, Newborn; Antioxidants; Ferroptosis; Hypoxia-Ischemia, Brain; Male; Maze Learning; | 2020 |
Protective effects of melatonin on the white matter damage of neonatal rats by regulating NLRP3 inflammasome activity.
Topics: Animals; Animals, Newborn; Apoptosis; Autophagy; Female; Hypoxia-Ischemia, Brain; Inflammasomes; Mel | 2021 |
Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Melat | 2021 |
Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: An in vivo and in vitro investigation in experimental models of neonatal HI brain injury.
Topics: Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Cells, Cultured; Disease Models, Animal; Fem | 2017 |
Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins.
Topics: Animals; Animals, Newborn; Biomarkers; Blotting, Western; Brain Edema; Colonic Diseases; Edema; Hypo | 2017 |
Effects of Antenatal Melatonin Treatment on the Cerebral Vasculature in an Ovine Model of Fetal Growth Restriction.
Topics: Animals; Antioxidants; Brain; Female; Fetal Growth Retardation; Hypoxia-Ischemia, Brain; Melatonin; | 2017 |
Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor.
Topics: Animals; Astrocytes; Blotting, Western; Cells, Cultured; Female; Genotype; Hippocampus; Hypoxia-Isch | 2018 |
Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo1H MR spectroscopy.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Hypoxia-Ischemia, Brain; Magnetic Reson | 2017 |
Melatonin Acts in Synergy with Hypothermia to Reduce Oxygen-Glucose Deprivation-Induced Cell Death in Rat Hippocampus Organotypic Slice Cultures.
Topics: Animals; Animals, Newborn; Cell Death; Glucose; Hippocampus; Hypothermia, Induced; Hypoxia; Hypoxia- | 2018 |
Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: A translational study.
Topics: Animals; Brain; Disease Models, Animal; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Melatonin; Ne | 2019 |
Mathematical evaluation of melatonin secretion in hypoxic ischemic encephalopathy.
Topics: Brain Diseases; Child; Child, Preschool; Female; Hip Joint; Humans; Hypoxia-Ischemia, Brain; Knee; M | 2018 |
Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Endoplasmic Reticulum Stress; Hypoxia-Ischemia, Brain; Melatonin; Neurons | 2014 |
Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat.
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Body Weight; Disease Models, Animal; Docosahexa | 2016 |
Melatonin influences NO/NOS pathway and reduces oxidative and nitrosative stress in a model of hypoxic-ischemic brain damage.
Topics: Animals; Cerebral Cortex; Glial Fibrillary Acidic Protein; Hypoxia-Inducible Factor 1, alpha Subunit | 2017 |
Melatonin regulates nitric oxide synthase expression in ischemic brain injury.
Topics: Animals; Blotting, Western; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Isoenzymes; | 2008 |
Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus).
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cell Count; Cerebral Cortex; | 2009 |
Cool treatment for birth asphyxia, but what's next?
Topics: Animals; Asphyxia Neonatorum; Combined Modality Therapy; Erythropoietin; Humans; Hypothermia, Induce | 2010 |
Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model.
Topics: Algorithms; Animals; Animals, Newborn; Disease Models, Animal; Drug Administration Schedule; Drug Co | 2011 |
The use of melatonin in hypoxic-ischemic brain damage: an experimental study.
Topics: Animals; Animals, Newborn; Antioxidants; Biomarkers; Drug Evaluation, Preclinical; Female; Hypoxia-I | 2012 |
Histological study of the protective effect of melatonin on neural cells after neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Brain; Brain Infarction; Demyelinating Diseases; D | 2012 |
Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Brain; Disease Models, Animal; Energ | 2013 |
Neuroprotective effects of melatonin against anoxia/aglycemia stress, as assessed by synaptic potentials and superoxide production in rat hippocampal slices.
Topics: Animals; Electric Stimulation; Free Radical Scavengers; Glucose; Hippocampus; Hypoxia-Ischemia, Brai | 2004 |
The protective role of melatonin in experimental hypoxic brain damage.
Topics: Animals; Antioxidants; Catalase; Female; Glutathione; Hypoxia-Ischemia, Brain; Lipid Peroxidation; M | 2005 |
[Neuroprotective effects of melatonin against hypoxic-ischemic brain damage in neonatal rats].
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Brain; Disease Models, Animal; Female; Hypoxia-I | 2006 |
Vascular endothelial growth factor and nitric oxide production in response to hypoxia in the choroid plexus in neonatal brain.
Topics: Age Factors; Animals; Animals, Newborn; Antigens, Surface; Capillary Permeability; Choroid Plexus; E | 2008 |
Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Hypoxia-Ischemia, Brain; Melatonin; Rats; | 2008 |