melatonin has been researched along with Alveolitis, Fibrosing in 11 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals." | 7.80 | Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice. ( Cao, LF; Chen, YH; Liu, RR; Liu, RY; Qing, HY; Wang, H; Wu, QQ; Xu, DX; Zhang, C; Zhao, H, 2014) |
| "Fibrosis is a common occurrence following organ injury and failure." | 6.53 | Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016) |
| "Twenty-five days after BLM treatment, pulmonary fibrosis was assessed as hydroxyproline content in lung homogenates." | 5.31 | The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. ( Arslan, SO; Coskun, A; Vural, H; Zerin, M, 2002) |
| "Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals." | 3.80 | Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice. ( Cao, LF; Chen, YH; Liu, RR; Liu, RY; Qing, HY; Wang, H; Wu, QQ; Xu, DX; Zhang, C; Zhao, H, 2014) |
| "Fibrosis is a common occurrence following organ injury and failure." | 2.53 | Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016) |
| "Treatment with melatonin upregulated Nrf2 expression, inhibited LPS-induced cell morphological change, reversed the expressions of EMT-related proteins, and reduced reactive oxygen species (ROS) production in A549 cells, as well as the levels of malondialdehyde (MDA) and anti-oxidative enzymes." | 1.56 | Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway. ( Ding, Z; Fei, G; Ji, S; Kang, J; Li, J; Wang, Y; Wu, X; Zhang, W, 2020) |
| "Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring." | 1.51 | Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction. ( Fang, R; Guo, Y; Jin, T; Li, F; Li, Y; Liang, H; Shan, H; Su, X; Wang, Y; Yang, R; Zhang, L; Zhao, X, 2019) |
| "Melatonin has direct and indirect free radical-detoxifying activity." | 1.33 | Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats. ( Erdogan, H; Fadillioglu, E; Iraz, M; Kotuk, M; Kuku, I; Yagmurca, M; Yildirim, Z, 2006) |
| "Twenty-five days after BLM treatment, pulmonary fibrosis was assessed as hydroxyproline content in lung homogenates." | 1.31 | The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. ( Arslan, SO; Coskun, A; Vural, H; Zerin, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Lan, YJ | 1 |
| Cheng, MH | 1 |
| Ji, HM | 1 |
| Bi, YQ | 1 |
| Han, YY | 1 |
| Yang, CY | 1 |
| Gu, X | 1 |
| Gao, J | 1 |
| Dong, HL | 1 |
| Aydin, P | 1 |
| Aksakalli-Magden, ZB | 1 |
| Civelek, MS | 1 |
| Karabulut-Uzuncakmak, S | 1 |
| Mokhtare, B | 1 |
| Ozkaraca, M | 1 |
| Alper, F | 1 |
| Halici, Z | 1 |
| Ding, Z | 1 |
| Wu, X | 1 |
| Wang, Y | 2 |
| Ji, S | 1 |
| Zhang, W | 1 |
| Kang, J | 1 |
| Li, J | 1 |
| Fei, G | 1 |
| Sheikholeslami, S | 1 |
| Aryafar, T | 1 |
| Abedi-Firouzjah, R | 1 |
| Banaei, A | 1 |
| Dorri-Giv, M | 1 |
| Zamani, H | 1 |
| Ataei, G | 1 |
| Majdaeen, M | 1 |
| Farhood, B | 1 |
| Zhang, L | 1 |
| Li, F | 1 |
| Su, X | 1 |
| Li, Y | 1 |
| Fang, R | 1 |
| Guo, Y | 1 |
| Jin, T | 1 |
| Shan, H | 2 |
| Zhao, X | 1 |
| Yang, R | 1 |
| Liang, H | 1 |
| Taslidere, E | 1 |
| Esrefoglu, M | 1 |
| Elbe, H | 1 |
| Cetin, A | 1 |
| Ates, B | 1 |
| Zhao, H | 1 |
| Wu, QQ | 1 |
| Cao, LF | 1 |
| Qing, HY | 1 |
| Zhang, C | 1 |
| Chen, YH | 1 |
| Wang, H | 1 |
| Liu, RY | 1 |
| Liu, RR | 1 |
| Xu, DX | 1 |
| Hu, W | 1 |
| Ma, Z | 1 |
| Jiang, S | 1 |
| Fan, C | 1 |
| Deng, C | 1 |
| Yan, X | 1 |
| Di, S | 1 |
| Lv, J | 1 |
| Reiter, RJ | 1 |
| Yang, Y | 1 |
| Genovese, T | 1 |
| Di Paola, R | 1 |
| Mazzon, E | 1 |
| Muià, C | 1 |
| Caputi, AP | 1 |
| Cuzzocrea, S | 1 |
| Yildirim, Z | 1 |
| Kotuk, M | 1 |
| Erdogan, H | 1 |
| Iraz, M | 1 |
| Yagmurca, M | 1 |
| Kuku, I | 1 |
| Fadillioglu, E | 1 |
| Arslan, SO | 1 |
| Zerin, M | 1 |
| Vural, H | 1 |
| Coskun, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19).[NCT04632732] | 140 participants (Actual) | Observational [Patient Registry] | 2020-10-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and Alveolitis, Fibrosing
| Article | Year |
|---|---|
The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review.
Topics: Animals; Humans; Lung; Lung Neoplasms; Melatonin; Pneumonia; Pulmonary Fibrosis; Radiation Injuries; | 2021 |
Melatonin: the dawning of a treatment for fibrosis?
Topics: Animals; Extracellular Matrix; Fibrosis; Heart Diseases; Humans; Kidney Diseases; Liver Cirrhosis; M | 2016 |
9 other studies available for melatonin and Alveolitis, Fibrosing
| Article | Year |
|---|---|
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression.
Topics: Animals; Bleomycin; Fibroblasts; Galectin 3; Humans; Lung; Melatonin; Mice; NF-E2-Related Factor 2; | 2023 |
The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF-Β1/HMGB1 signaling pathway.
Topics: Animals; Bleomycin; HMGB1 Protein; Lung; Melatonin; NLR Family, Pyrin Domain-Containing 3 Protein; P | 2023 |
Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway.
Topics: A549 Cells; Acute Lung Injury; Alveolar Epithelial Cells; Antioxidants; Epithelial-Mesenchymal Trans | 2020 |
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Topics: Animals; Apelin; Apoptosis; Bleomycin; Cell Line, Tumor; Cellular Senescence; Epithelial Cells; Lung | 2019 |
Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Fe | 2014 |
Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice.
Topics: Animals; Antineoplastic Agents; Bleomycin; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulu | 2014 |
Melatonin limits lung injury in bleomycin treated mice.
Topics: Animals; Bleomycin; Immunohistochemistry; Lung; Male; Melatonin; Mice; Poly Adenosine Diphosphate Ri | 2005 |
Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats.
Topics: Animals; Antioxidants; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydroxyproli | 2006 |
The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Bleomycin; Female; Lipid Peroxidation; Lung; Mel | 2002 |