melatonin has been researched along with Alloxan Diabetes in 181 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previous studies have proved that melatonin could protect against cerebral ischemia-reperfusion (CIR) injury in non-diabetic stroke models; however, its roles and the underlying mechanisms against CIR injury in diabetic mice remain unknown." | 8.02 | Melatonin ameliorates cerebral ischemia-reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1-BMAL1 pathway. ( Cao, Q; Gao, W; Li, BY; Liu, L; Xia, Z; Zeng, C; Zhao, B, 2021) |
| " This study aimed to investigate the efficacy of melatonin (MLT) in improving diabetes-associated cognitive decline and the underlying mechanism involved." | 8.02 | Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway. ( Cui, C; Cui, Y; He, Q; Hu, H; Lin, P; Ren, J; Song, J; Sun, Y; Wang, K; Wang, Y; Yang, M, 2021) |
| "The present study analyzed whether melatonin could mediate the expression of VEGF, IL-6 and TNF-α, as well as the apoptotic index in rats with diabetic retinopathy." | 7.96 | Melatonin regulates the expression of inflammatory cytokines, VEGF and apoptosis in diabetic retinopathy in rats. ( Almeida, LL; Bezerra de Sá, F; Cavalcanti Lapa Neto, CJ; Coelho Teixeira, ÁA; Ferreira de Melo, IM; Lima da Silva Souza, EH; Martins Ferreira, CG; Paz de Castro, MV; Teixeira, VW, 2020) |
| "Melatonin is a hormone produced by the pineal gland, and it has extensive beneficial effects on various tissue and organs; however, whether melatonin has any effect on cardiac fibrosis in the pathogenesis of diabetic cardiomyopathy (DCM) is still unknown." | 7.96 | Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. ( Che, H; Dong, R; Li, H; Li, Y; Liu, Y; Lv, J; Sahil, A; Wang, L; Wang, Y; Xue, H; Yang, Z, 2020) |
| "Melatonin can be considered as a promising solution in preventing neuroinflammation development in T2DM owing to its ability to render the oxidative stress and accompanied low-grade systemic inflammation." | 7.96 | Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. ( Elguindy, NM; Hashem, HM; Maher, AM; Saleh, SR; Yacout, GA, 2020) |
| "Melatonin can inhibit renal inflammation and fibrosis by inhibiting the NF-κB and TGF-β1/Smad3 signaling pathways, and melatonin may be a promising therapeutic target in diabetic nephropathy." | 7.96 | Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice. ( Fan, Z; Qi, X; Wu, Y; Xia, L; Yang, W, 2020) |
| "To explore the neuroprotective effects and its possible mechanisms of melatonin (MT) on erectile dysfunction in streptozotocin-induced diabetic rats." | 7.88 | Neuroprotective effects of melatonin on erectile dysfunction in streptozotocin-induced diabetic rats. ( Hou, JQ; Hui, Y; Zhang, JL; Zhou, F, 2018) |
| "To investigate the effects of aerobic exercise and melatonin on osteoporosis in type 2 diabetic rats." | 7.85 | [Effects of aerobic exercise combined with melatonin on osteoporosis of type II diabetic rats]. ( Jing, HF; Wang, XM, 2017) |
| "The aim of this study is to evaluate the effects of systemic melatonin treatment on serum oxidative stress index (OSI) and alveolar bone loss (ABL) in rats with diabetes mellitus (DM) and periodontitis." | 7.83 | Effects of Melatonin on Oxidative Stress Index and Alveolar Bone Loss in Diabetic Rats With Periodontitis. ( Arabaci, T; Gedikli, S; Kara, A; Kermen, E; Kizildag, A; Kose, O; Ozkanlar, S; Yemenoglu, H, 2016) |
| "The aim of this study examines the effect of systemic melatonin administration on proinflammatory cytokine levels, apoptosis, alveolar bone loss (ABL), lipid metabolism, and diabetic control in in rats with diabetes mellitus (DM) and ligature-induced periodontitis." | 7.83 | The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis. ( Aydemir Turkal, H; Balci Yuce, H; Benli, I; Cayli, S; Karatas, O; Ocakli, S; Pirim Gorgun, E, 2016) |
| "The aim of this study was to investigate the effects of melatonin on low-grade inflammation and oxidative stress in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM)." | 7.79 | Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. ( Adem, A; Agil, A; Fernández-Vázquez, G; Ibán-Arias, R; Jiménez-Aranda, A; Marchal, JA; Navarro-Alarcón, M; Reiter, RJ, 2013) |
| " Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure." | 7.77 | Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011) |
| "Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed." | 5.91 | Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023) |
| " In our study, we evaluate the effect of melatonin on the diabetic retinal alterations in male albino rats to the effect of melatonin combined with stem cells." | 5.91 | A comparative study between the possible protective role of melatonin versus its combination with adipose derived-mesenchymal stem cells on experimentally induced diabetic retinopathy in adult male albino rats (Histological and immunohistochemical study). ( Elsammak, GA; Elsayed, TG; Mostafa, SA; Reda, S, 2023) |
| " Additionally, due to its variable absorption and poor oral bioavailability necessitates the development of alternative delivery methods." | 5.91 | Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats. ( Abdelaziz, M; Alaa, H; El-Karamany, Y; Farid, A; Magdy, S; Mansour, M; Mohsen, S; Mustafa, M, 2023) |
| "Melatonin treatment reversed the harmful effects of hyperglycemia on EPC through adenosine monophosphate-activated protein kinase-related mechanisms to increase eNOS phosphorylation and heme oxygenase-1 expression." | 5.72 | Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning. ( Chen, CY; Chou, RH; Huang, HL; Huang, PH; Kuo, CS; Lin, SJ; Tsai, HY; Wei, JH, 2022) |
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 5.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Melatonin was administered i." | 5.62 | Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. ( Albazal, A; Delshad, AA; Roghani, M, 2021) |
| "Melatonin is a pineal hormone that regulates circadian and seasonal rhythms and most likely is involved in regulating glucose metabolism." | 5.48 | Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes. ( Basic, J; Cvetkovic, T; Despotovic, M; Djordjevic, B; Kocic, G; Pavlovic, D; Sokolovic, D; Stoimenov, TJ; Velickov, A; Veljkovic, A; Zivanovic, S, 2018) |
| "Type 2 diabetes mellitus is often complicated by osteoporosis, a process which may involve osteoblast autophagy." | 5.43 | Melatonin suppresses autophagy in type 2 diabetic osteoporosis. ( Liu, F; Liu, JH; Meng, HZ; Shi, PX; Sun, GH; Yang, B; Yang, MW; Yang, RF; Zhang, WL, 2016) |
| "Melatonin was administered (10 mg/kg/d) by gavage for 12 weeks." | 5.43 | Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation. ( Su, H; Tang, HQ; Tang, ST; Wang, CJ; Wang, Y; Wei, W; Zhang, Q; Zhou, Q; Zhu, HQ, 2016) |
| "Melatonin is an endogenous hormone that exhibits a variety of biological effects including antioxidant and anti-inflammatory functions." | 5.43 | Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy. ( Cai, J; Chang, Q; Fan, J; Jiang, T; Xu, G; Zhang, X, 2016) |
| "Melatonin is a neurohormone that works as a nighttime signal for circadian integrity and health maintenance." | 5.40 | Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia. ( Afeche, SC; Amaral, FG; Barone, M; Bordin, S; Cipolla-Neto, J; do Carmo Buonfiglio, D; Lima, L; Menna-Barreto, L; Peliciari-Garcia, RA; Peres, R; Reiter, RJ; Scavone, C; Scialfa, JH; Turati, AO, 2014) |
| "Melatonin was administered to streptozotocin-induced type I diabetic rats." | 5.38 | Mobilisation of endothelial progenitor cells: one of the possible mechanisms involved in the chronic administration of melatonin preventing erectile dysfunction in diabetic rats. ( Chen, Y; Dai, YT; Li, XX; Lin, HC; Qiu, XF; Wang, R; Yu, W, 2012) |
| "Melatonin treatment reversed all these oxidant and antioxidant parameters to control values as well as serum liver enzymes." | 5.35 | Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus. ( Fadillioglu, E; Gursul, C; Iraz, M; Kurcer, Z; Parlakpinar, H, 2008) |
| "The purpose of this study was to investigate the effects of chronic administration of melatonin on renal ischemia/reperfusion (IR) injury in streptozotocin (STZ)-induced diabetic rats." | 5.34 | Protective effects of chronic melatonin treatment against renal ischemia/reperfusion injury in streptozotocin-induced diabetic rats. ( Baba, F; Fadillioglu, E; Gül, M; Iraz, M; Kurcer, Z; Parlakpinar, H; Tasdemir, S; Vardi, N, 2007) |
| " Previous studies have proved that melatonin could protect against cerebral ischemia-reperfusion (CIR) injury in non-diabetic stroke models; however, its roles and the underlying mechanisms against CIR injury in diabetic mice remain unknown." | 4.02 | Melatonin ameliorates cerebral ischemia-reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1-BMAL1 pathway. ( Cao, Q; Gao, W; Li, BY; Liu, L; Xia, Z; Zeng, C; Zhao, B, 2021) |
| "In this study, the combined effects of four-week swimming training and melatonin were examined on the oxidative response, inflammation, apoptosis, and angiogenesis capacity of cardiac tissue in the mouse model of diabetes." | 4.02 | Melatonin and prolonged physical activity attenuated the detrimental effects of diabetic condition on murine cardiac tissue. ( Ahmadi, M; Bolboli, L; Haghighi, L; Hassanpour, M; Keyhanmanesh, R; Mahdipour, M; Rahbarghazi, A; Rahbarghazi, R; Siahkouhian, M; Sokouti Nasimi, F, 2021) |
| " This study aimed to investigate the efficacy of melatonin (MLT) in improving diabetes-associated cognitive decline and the underlying mechanism involved." | 4.02 | Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway. ( Cui, C; Cui, Y; He, Q; Hu, H; Lin, P; Ren, J; Song, J; Sun, Y; Wang, K; Wang, Y; Yang, M, 2021) |
| "Melatonin can be considered as a promising solution in preventing neuroinflammation development in T2DM owing to its ability to render the oxidative stress and accompanied low-grade systemic inflammation." | 3.96 | Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. ( Elguindy, NM; Hashem, HM; Maher, AM; Saleh, SR; Yacout, GA, 2020) |
| "Melatonin can inhibit renal inflammation and fibrosis by inhibiting the NF-κB and TGF-β1/Smad3 signaling pathways, and melatonin may be a promising therapeutic target in diabetic nephropathy." | 3.96 | Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice. ( Fan, Z; Qi, X; Wu, Y; Xia, L; Yang, W, 2020) |
| "The present study analyzed whether melatonin could mediate the expression of VEGF, IL-6 and TNF-α, as well as the apoptotic index in rats with diabetic retinopathy." | 3.96 | Melatonin regulates the expression of inflammatory cytokines, VEGF and apoptosis in diabetic retinopathy in rats. ( Almeida, LL; Bezerra de Sá, F; Cavalcanti Lapa Neto, CJ; Coelho Teixeira, ÁA; Ferreira de Melo, IM; Lima da Silva Souza, EH; Martins Ferreira, CG; Paz de Castro, MV; Teixeira, VW, 2020) |
| "Melatonin is a hormone produced by the pineal gland, and it has extensive beneficial effects on various tissue and organs; however, whether melatonin has any effect on cardiac fibrosis in the pathogenesis of diabetic cardiomyopathy (DCM) is still unknown." | 3.96 | Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. ( Che, H; Dong, R; Li, H; Li, Y; Liu, Y; Lv, J; Sahil, A; Wang, L; Wang, Y; Xue, H; Yang, Z, 2020) |
| "To explore the neuroprotective effects and its possible mechanisms of melatonin (MT) on erectile dysfunction in streptozotocin-induced diabetic rats." | 3.88 | Neuroprotective effects of melatonin on erectile dysfunction in streptozotocin-induced diabetic rats. ( Hou, JQ; Hui, Y; Zhang, JL; Zhou, F, 2018) |
| "To investigate the effects of aerobic exercise and melatonin on osteoporosis in type 2 diabetic rats." | 3.85 | [Effects of aerobic exercise combined with melatonin on osteoporosis of type II diabetic rats]. ( Jing, HF; Wang, XM, 2017) |
| "The aim of this study examines the effect of systemic melatonin administration on proinflammatory cytokine levels, apoptosis, alveolar bone loss (ABL), lipid metabolism, and diabetic control in in rats with diabetes mellitus (DM) and ligature-induced periodontitis." | 3.83 | The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis. ( Aydemir Turkal, H; Balci Yuce, H; Benli, I; Cayli, S; Karatas, O; Ocakli, S; Pirim Gorgun, E, 2016) |
| "The aim of this study is to evaluate the effects of systemic melatonin treatment on serum oxidative stress index (OSI) and alveolar bone loss (ABL) in rats with diabetes mellitus (DM) and periodontitis." | 3.83 | Effects of Melatonin on Oxidative Stress Index and Alveolar Bone Loss in Diabetic Rats With Periodontitis. ( Arabaci, T; Gedikli, S; Kara, A; Kermen, E; Kizildag, A; Kose, O; Ozkanlar, S; Yemenoglu, H, 2016) |
| " We examined the effects of the antioxidant action of melatonin against necrosis-inducing DNA damage in hepatocytes of streptozotocin (STZ)-induced diabetic rats." | 3.80 | Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats. ( Bogojević, D; Grigorov, I; Ivanović-Matić, S; Jovanović, S; Martinović, V; Petrović, A; Poznanović, G; Zolotarevski, L, 2014) |
| "Hyperglycemia increased retinal oxidation as measured through levels of nitrotyrosine and malondialdehyde." | 3.80 | Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats. ( Bakariş, S; Durdu, H; Ergün, Y; Ganiyusufoğlu, E; Kılınç, M; Ozdemir, G, 2014) |
| "The aim of this study was to investigate the effects of melatonin on low-grade inflammation and oxidative stress in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM)." | 3.79 | Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. ( Adem, A; Agil, A; Fernández-Vázquez, G; Ibán-Arias, R; Jiménez-Aranda, A; Marchal, JA; Navarro-Alarcón, M; Reiter, RJ, 2013) |
| " Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure." | 3.77 | Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011) |
| "Melatonin is a powerful antioxidant that has a wide range of biological activities." | 2.82 | Renal Protective Effects of Melatonin in Animal Models of Diabetes Mellitus-Related Kidney Damage: A Systematic Review and Meta-Analysis. ( Cai, Y; Jiang, Y; Liu, WJ; Liu, Y; Luo, Q; Tian, L; Zhao, Q, 2022) |
| " Additionally, due to its variable absorption and poor oral bioavailability necessitates the development of alternative delivery methods." | 1.91 | Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats. ( Abdelaziz, M; Alaa, H; El-Karamany, Y; Farid, A; Magdy, S; Mansour, M; Mohsen, S; Mustafa, M, 2023) |
| " In our study, we evaluate the effect of melatonin on the diabetic retinal alterations in male albino rats to the effect of melatonin combined with stem cells." | 1.91 | A comparative study between the possible protective role of melatonin versus its combination with adipose derived-mesenchymal stem cells on experimentally induced diabetic retinopathy in adult male albino rats (Histological and immunohistochemical study). ( Elsammak, GA; Elsayed, TG; Mostafa, SA; Reda, S, 2023) |
| "Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed." | 1.91 | Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023) |
| "Melatonin treatment normalised the splenic cellularity and increased the splenocyte proliferation in a dose-dependent manner." | 1.72 | Melatonin attenuates diabetes-induced oxidative stress in spleen and suppression of splenocyte proliferation in laboratory mice. ( Deb, A; Singh, SS; Sutradhar, S, 2022) |
| "Melatonin treatment reversed the harmful effects of hyperglycemia on EPC through adenosine monophosphate-activated protein kinase-related mechanisms to increase eNOS phosphorylation and heme oxygenase-1 expression." | 1.72 | Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning. ( Chen, CY; Chou, RH; Huang, HL; Huang, PH; Kuo, CS; Lin, SJ; Tsai, HY; Wei, JH, 2022) |
| "The treatment with melatonin improved wound healing by promoting wound closure earlier than the control group evaluated." | 1.72 | Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes. ( Amaral, AC; Celes, MRN; de Menezes, LB; de Oliveira Junior, ER; de Souza, TR; Lima, EM; Miguel, MP; Rincon, GCN; Rocha, VL, 2022) |
| "Melatonin treatment was investigated to assess the beneficial effects on injured steroidogenic function in DM due to its regulatory roles in mitochondria and autophagy." | 1.72 | Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway. ( Lin, S; Lv, Z; Wang, P; Zhang, S, 2022) |
| "Melatonin was administered in daily injections of 0." | 1.72 | Melatonin Administration Prevents Placental and Fetal Changes Induced by Gestational Diabetes. ( Alves, ÉR; D'Assunção, CG; de Albuquerque, YML; de Melo, IMF; Ferreira, CGM; Neto, CJCL; Teixeira, ÁAC; Wanderley Teixeira, V, 2022) |
| "Melatonin or insulin treatment alone or in combination resulted in significant restoration of the relative expression of both melatonin receptors in the renal cortex." | 1.72 | Coadministration of Melatonin and Insulin Improves Diabetes-Induced Impairment of Rat Kidney Function. ( Brown, GM; Cardinali, DP; Hajam, YA; Pandi-Perumal, SR; Rai, S; Reiter, RJ, 2022) |
| "Melatonin was administered i." | 1.62 | Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. ( Albazal, A; Delshad, AA; Roghani, M, 2021) |
| "Melatonin has been proved to be a free radical scavenger with strong antioxidant activity, and its protective effect on diabetes and the complications has been confirmed." | 1.62 | Melatonin attenuates aortic oxidative stress injury and apoptosis in STZ-diabetes rats by Notch1/Hes1 pathway. ( Li, BY; Ma, JX; Pei, F; Ren, BC; Zhang, W, 2021) |
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 1.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Alloxan diabetes was evoked via intraperitoneal injection with a 5% solution of alloxan monohydrate in a dose of 170 mg/kg of body weight." | 1.56 | EFFECT OF MELATONIN INJECTIONS ON THE GLUTATHIONE SYSTEM IN HEART TISSUE OF RATS UNDER EXPERIMENTAL DIABETES. ( Kushnir, O; Palamar, A; Skrynchuk, O; Vepriuk, Y; Yaremii, I, 2020) |
| "Melatonin was administered at a dose of 10 mg/kg in drinking water every day for 20 days at night." | 1.56 | Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels. ( Alves, ÉR; Ferreira, CGM; Melo, IMF; Neto, CJCL; Santos, LCDS; Silva Junior, VAD; Silva, MVD; Teixeira, ÁAC; Vieira Filho, LD; Wanderley Teixeira, V, 2020) |
| "Melatonin was injected intraperitoneally at a dose of 50 mg/kg/day for 56 days to group 4." | 1.51 | Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of rapamycin (mTOR) signaling pathway. ( Güntekin, Ü; Kandemir, YB; Tosun, V, 2019) |
| "Melatonin was provided in drinking water (10 μg/kg/day) from age 5 weeks until the end of experiment." | 1.48 | Pathological lesions and global DNA methylation in rat prostate under streptozotocin-induced diabetes and melatonin supplementation. ( de Campos, SGP; Gobbo, MG; Góes, RM; Ribeiro, DL; Taboga, SR; Tamarindo, GH, 2018) |
| "Melatonin treatment has been reported to be capable of ameliorating metabolic diabetes-related abnormalities but also to cause hypogonadism in rats." | 1.48 | Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats. ( Andreotti, S; Campana, AB; Coelho-de-Souza, AN; de Proença, ARG; Donato-Junior, J; Lima, FB; Oliveira, AC; Oliveira, KA; Sertie, RAL; Vasconcelos, RP, 2018) |
| "The melatonin caused an increase in antioxidant capacity and decreased the expression of cleaved-caspase 3." | 1.48 | Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats. ( Ayazoğlu, TA; Çomaklı, S; Erol, HS; Kuyrukluyıldız, U; Onk, D; Onk, OA; Özkaraca, M; Ünver, S, 2018) |
| "Melatonin is a pineal hormone that regulates circadian and seasonal rhythms and most likely is involved in regulating glucose metabolism." | 1.48 | Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes. ( Basic, J; Cvetkovic, T; Despotovic, M; Djordjevic, B; Kocic, G; Pavlovic, D; Sokolovic, D; Stoimenov, TJ; Velickov, A; Veljkovic, A; Zivanovic, S, 2018) |
| "Melatonin treatment reduced expression and activity of ROCK1 and ROCK2, which suppressed TGF-β2-induced hyperpermeability of GEnCs and EndMT of GEnCs." | 1.48 | Melatonin Attenuates Endothelial-to-Mesenchymal Transition of Glomerular Endothelial Cells via Regulating miR-497/ROCK in Diabetic Nephropathy. ( Gao, S; Liu, F; Xu, R; Yin, J; Zhang, S, 2018) |
| "Melatonin treatment to diabetic rats restored the alteration in physiological and biochemical markers." | 1.48 | Protective Role of Melatonin in Streptozotocin Induced Pancreatic Damages in Diabetic Wistar Rat. ( Ahmad Hajam, Y; Basheer, M; Ghosh, H; Rai, S; Singh, S, 2018) |
| "Fluoxetine and melatonin treatments decreased TBARS in both cortices." | 1.46 | The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices. ( Boudah, A; Jasmin, L; Rebai, R, 2017) |
| "Melatonin was administered (10 mg/kg/d) by gavage for 12 weeks." | 1.43 | Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation. ( Su, H; Tang, HQ; Tang, ST; Wang, CJ; Wang, Y; Wei, W; Zhang, Q; Zhou, Q; Zhu, HQ, 2016) |
| "Type 2 diabetes mellitus is often complicated by osteoporosis, a process which may involve osteoblast autophagy." | 1.43 | Melatonin suppresses autophagy in type 2 diabetic osteoporosis. ( Liu, F; Liu, JH; Meng, HZ; Shi, PX; Sun, GH; Yang, B; Yang, MW; Yang, RF; Zhang, WL, 2016) |
| "Melatonin was administered (10 mg/kg/day) by gavage for 24 weeks." | 1.43 | Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation. ( Fan, T; Gui, S; Hu, R; Su, H; Tang, S; Wang, Y; Yang, X; Zhou, Q; Zou, D; Zuo, L, 2016) |
| "Melatonin was provided in drinking water (10 μg/kg b." | 1.43 | Melatonin intake since weaning ameliorates steroidogenic function and sperm motility of streptozotocin-induced diabetic rats. ( da Costa, CF; Gobbo, MG; Góes, RM; Pinto-Fochi, ME; Taboga, SR, 2016) |
| "Melatonin is an endogenous hormone that exhibits a variety of biological effects including antioxidant and anti-inflammatory functions." | 1.43 | Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy. ( Cai, J; Chang, Q; Fan, J; Jiang, T; Xu, G; Zhang, X, 2016) |
| "Melatonin treatment up-regulated SIRT1 expression, reduced oxidative damage, and suppressed PERK/eIF2α/ATF4 signaling." | 1.42 | Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin. ( Chen, W; Dong, X; Duan, W; Jin, Z; Liang, H; Liu, J; Yang, J; Yang, Y; Yi, D; Yi, W; Yu, L; Yu, S; Zhai, M; Zhao, G, 2015) |
| "Melatonin treatment to ZDF rats decreases serum levels of ALT (P < 0." | 1.42 | Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats. ( Abdo, W; Agil, A; El-Hammadi, M; Fernández-Vázquez, G; Jiménez-Aranda, A; Reiter, RJ; Tassi, M, 2015) |
| "Melatonin was more efficient in reducing MDA levels than other antioxidants (p < 0." | 1.42 | Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats. ( Ates, B; Elbe, H; Esrefoglu, M; Taskapan, C; Vardi, N; Yologlu, S, 2015) |
| "Melatonin treatment to healthy rats caused a 47% increase in epididymal GPx activity in 14-week-old rats." | 1.42 | Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes. ( Costa, CF; de Almeida, EA; Gobbo, MG; Góes, RM; Silva, DG, 2015) |
| "Melatonin is a neurohormone that works as a nighttime signal for circadian integrity and health maintenance." | 1.40 | Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia. ( Afeche, SC; Amaral, FG; Barone, M; Bordin, S; Cipolla-Neto, J; do Carmo Buonfiglio, D; Lima, L; Menna-Barreto, L; Peliciari-Garcia, RA; Peres, R; Reiter, RJ; Scavone, C; Scialfa, JH; Turati, AO, 2014) |
| "Melatonin treatment did not influence plasma levels of these antioxidant minerals (Cu, Zn, Fe, and Mn) in ZDF groups (M-ZDF versus C-ZDF group) and ZL (M-ZL versus C-ZL group) rats with the exception of Zn, whose mean plasma level was lower in the M-ZL versus C-ZL group." | 1.39 | Antioxidant activity of melatonin in diabetes in relation to the regulation and levels of plasma Cu, Zn, Fe, Mn, and Se in Zucker diabetic fatty rats. ( Agil, A; Blanca-Herrera, RM; Navarro-Alarcon, M; Ruiz-Ojeda, FJ, 2013) |
| "Melatonin was administered to streptozotocin-induced type I diabetic rats." | 1.38 | Mobilisation of endothelial progenitor cells: one of the possible mechanisms involved in the chronic administration of melatonin preventing erectile dysfunction in diabetic rats. ( Chen, Y; Dai, YT; Li, XX; Lin, HC; Qiu, XF; Wang, R; Yu, W, 2012) |
| "Melatonin treatment reduced hyperglycemia, polydipsia, and polyphagia as well as improved insulin resistance as demonstrated by constant glucose disappearance rate and homeostasis model of assessment-insulin resistance." | 1.38 | Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment. ( Andreotti, S; Campaña, AB; Carpinelli, AR; Cipolla-Neto, J; de Oliveira, AC; de Proença, AR; de Souza, AH; Farias, Tda S; Lima, FB; Sertié, RA; Torres-Leal, FL, 2012) |
| "Taurine was effective more than melatonin in reducing CYP2E1 activity and expression; therefore antioxidants might prove beneficial in type 1 diabetes associated with manifestations of liver injury." | 1.37 | Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. ( El-Batch, M; Hassan, AM; Mahmoud, HA, 2011) |
| "Melatonin was supplemented at a dose of 3 mg/kg/day intraperitoneally for four weeks." | 1.37 | Interactive effects of melatonin, exercise and diabetes on liver glycogen levels. ( Akil, M; Avunduk, MC; Baltaci, AK; Bicer, M; Kilic, M; Mogulkoc, R, 2011) |
| " Owing to aldose reductase pharmacophore requirements for an acidic proton, most aldose reductase inhibitors contain an acetic acid moiety, ionized at physiological pH, resulting in poor bioavailability of the drugs." | 1.37 | (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature. ( Juskova, M; Milackova, I; Snirc, V; Stefek, M; Triantos, N; Tsantili-Kakoulidou, A, 2011) |
| "Melatonin pre-treatment prevents the injurious effects of streptozocin in rats." | 1.36 | Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism. ( Ahmadi, R; Akmali, M; Vessal, M, 2010) |
| "Melatonin treatment reversed all these oxidant and antioxidant parameters to control values as well as serum liver enzymes." | 1.35 | Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus. ( Fadillioglu, E; Gursul, C; Iraz, M; Kurcer, Z; Parlakpinar, H, 2008) |
| "Melatonin was administered intraperitoneally at the dose of 10 mg/kg for 5 days." | 1.35 | Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats. ( Cilaker, S; Gumustekin, M; Guneli, E; Ozturk, H; Tugyan, K; Uysal, N, 2008) |
| "Melatonin treatment (10 mg/kg, 18 days) did not influence the level of hyperglycemia or glycated hemoglobin and it had little effect on the activities of antioxidative enzymes." | 1.34 | Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats. ( Bryszewska, M; Kubyshin, VL; Lapshina, EA; Maksimchik, YZ; Reiter, RJ; Sudnikovich, EJ; Zabrodskaya, SV; Zavodnik, IB, 2007) |
| "The purpose of this study was to investigate the effects of chronic administration of melatonin on renal ischemia/reperfusion (IR) injury in streptozotocin (STZ)-induced diabetic rats." | 1.34 | Protective effects of chronic melatonin treatment against renal ischemia/reperfusion injury in streptozotocin-induced diabetic rats. ( Baba, F; Fadillioglu, E; Gül, M; Iraz, M; Kurcer, Z; Parlakpinar, H; Tasdemir, S; Vardi, N, 2007) |
| "Melatonin treatment did not improve these hemorheological abnormalities." | 1.34 | Short-term melatonin treatment improved diabetic nephropathy but did not affect hemorheological changes in diabetic rats. ( Bediz, CS; Ergonen, AT; Gumustekin, M; Guneli, E; Ozdemir, MH; Tekmen, I; Topcu, A; Tugyan, K; Uysal, N, 2007) |
| "Melatonin was also effective in restoring the impaired SNP-induced vasorelaxation seen in endothelium-denuded or L-NAME-treated aortic rings from hyperglycemic rats." | 1.33 | Melatonin restores endothelium-dependent relaxation in aortic rings of pancreatectomized rats. ( Cardinali, DP; Linares, LM; Obaya-Naredo, D; Pinto, JE; Reyes-Toso, CF; Ricci, CR; Rodríguez, RR, 2005) |
| "Melatonin treatment caused a sharp decrease in the elevated serum glucose, a slight increase in the lowered serum insulin concentrations and small partial regeneration/proliferation of beta-cells of islets." | 1.33 | Depression of glucose levels and partial restoration of pancreatic beta-cell damage by melatonin in streptozotocin-induced diabetic rats. ( Kanter, M; Karaca, T; Sagmanligil, HO; Uysal, H, 2006) |
| "Treatment with melatonin and vitamin E significantly ameliorated learning and memory performance." | 1.33 | Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats. ( Baydas, G; Tuzcu, M, 2006) |
| "Treatment with melatonin changed them to near control values." | 1.32 | Effects of melatonin on oxidative-antioxidative status of tissues in streptozotocin-induced diabetic rats. ( Aksoy, N; Aksoy, S; Sabuncu, T; Vural, H, 2003) |
| "Melatonin treatment reversed STZ-induced reduction of GSH-Px activity without having an effect on blood glucose." | 1.32 | Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats. ( Bukan, N; Cam, M; Ercan, F; Guven, A; Ustündag, N; Yavuz, O, 2003) |
| "Treatment with melatonin resulted in an obvious reduction of GFAP-immunoreactive astrocytes in hippocampus." | 1.32 | Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. ( Akdemir, I; Baydas, G; Nedzvetskii, VS; Reiter, RJ; Tuzcu, M; Yasar, A, 2003) |
| " Dose-response curves for acetylcholine-induced, endothelium-related relaxation of aortic rings (after previous exposure to phenylephrine) and for phenylephrine-induced vasoconstriction were conducted." | 1.32 | Effect of melatonin on vascular reactivity in pancreatectomized rats. ( Arán, M; Cardinali, DP; Linares, LM; Pinto, JE; Reyes-Toso, CF; Ricci, CR; Rodríguez, RR, 2004) |
| "Treatment with melatonin (EC(50) 4." | 1.32 | Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. ( Ayanğolu-Dülger, G; Paskaloglu, K; Sener, G, 2004) |
| " Dose-response curves for acetylcholine-induced, endothelium-related relaxation of aortic rings (after previous exposure to phenylephrine) and for serotonin-induced vasoconstriction were conducted in the presence or absence of 10-5 mol/L melatonin." | 1.31 | Vascular reactivity in diabetic rats: effect of melatonin. ( Albornoz, LE; Cardinali, DP; Damiano, PF; Linares, LM; Reyes-Toso, CF; Rosón, MI, 2002) |
| "Melatonin was administered s." | 1.31 | Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. ( Baydas, G; Canatan, H; Turkoglu, A, 2002) |
| "Treatment with melatonin markedly reduced the STZ-induced effects on plasma sialic acid and TBARS and was associated with restoration of hyperglycemia to control blood glucose levels." | 1.31 | Melatonin administration affects plasma total sialic acid and lipid peroxidation levels in streptozotocin induced diabetic rats. ( Görgün, FM; Gümüştaş, MK; Kökogu, E; Oztürk, Z, 2002) |
| " Chronic administration of melatonin (n = 6) and taurine (n = 6) prevented increases in glomerular TGF-beta1 and fibronectin mRNAs and proteinuria without having effect on blood glucose." | 1.30 | Melatonin and taurine reduce early glomerulopathy in diabetic rats. ( Ha, H; Kim, KH; Yu, MR, 1999) |
| "Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats." | 1.27 | Hormonal modulation of pineal melatonin synthesis in rats and Syrian hamsters: effects of streptozotocin-induced diabetes and insulin injections. ( Champney, TH; Craft, CM; Holtorf, AP; Reiter, RJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.21) | 18.7374 |
| 1990's | 3 (1.66) | 18.2507 |
| 2000's | 42 (23.20) | 29.6817 |
| 2010's | 84 (46.41) | 24.3611 |
| 2020's | 48 (26.52) | 2.80 |
| Authors | Studies |
|---|---|
| Stefek, M | 1 |
| Tsantili-Kakoulidou, A | 1 |
| Milackova, I | 1 |
| Juskova, M | 1 |
| Snirc, V | 1 |
| Triantos, N | 1 |
| El Aasar, H | 1 |
| Rashed, L | 1 |
| El Sadik, A | 1 |
| Amer, R | 1 |
| Emam, H | 1 |
| Li, X | 3 |
| He, J | 1 |
| Li, Y | 3 |
| Zhou, Y | 1 |
| Cai, S | 1 |
| Hajam, YA | 2 |
| Rai, S | 3 |
| Pandi-Perumal, SR | 1 |
| Brown, GM | 1 |
| Reiter, RJ | 10 |
| Cardinali, DP | 4 |
| Liu, L | 3 |
| Cao, Q | 2 |
| Gao, W | 2 |
| Li, BY | 2 |
| Zeng, C | 1 |
| Xia, Z | 2 |
| Zhao, B | 2 |
| de Melo, IMF | 1 |
| Ferreira, CGM | 2 |
| Alves, ÉR | 2 |
| D'Assunção, CG | 1 |
| Neto, CJCL | 2 |
| de Albuquerque, YML | 1 |
| Wanderley Teixeira, V | 2 |
| Teixeira, ÁAC | 2 |
| Bilgin, S | 1 |
| Nermin Sivrikoz, O | 1 |
| Çavdar, E | 1 |
| Cetin, O | 1 |
| Luo, Q | 1 |
| Cai, Y | 1 |
| Zhao, Q | 1 |
| Jiang, Y | 1 |
| Tian, L | 1 |
| Liu, Y | 4 |
| Liu, WJ | 1 |
| Li, XQ | 1 |
| Wang, Y | 8 |
| Yang, SJ | 1 |
| Ma, X | 1 |
| Li, SH | 1 |
| Niu, D | 1 |
| Duan, X | 1 |
| Wang, P | 1 |
| Zhang, S | 2 |
| Lin, S | 1 |
| Lv, Z | 1 |
| de Souza, TR | 1 |
| Rocha, VL | 1 |
| Rincon, GCN | 1 |
| de Oliveira Junior, ER | 1 |
| Celes, MRN | 1 |
| Lima, EM | 1 |
| Amaral, AC | 1 |
| Miguel, MP | 1 |
| de Menezes, LB | 1 |
| Kuo, CS | 1 |
| Chen, CY | 1 |
| Huang, HL | 1 |
| Tsai, HY | 1 |
| Chou, RH | 1 |
| Wei, JH | 1 |
| Huang, PH | 1 |
| Lin, SJ | 1 |
| Siddhi, J | 1 |
| Sherkhane, B | 1 |
| Kalavala, AK | 1 |
| Arruri, V | 1 |
| Velayutham, R | 1 |
| Kumar, A | 1 |
| Akgun-Unal, N | 4 |
| Ozyildirim, S | 3 |
| Unal, O | 3 |
| Gulbahce-Mutlu, E | 2 |
| Mogulkoc, R | 8 |
| Baltaci, AK | 8 |
| Ertik, O | 2 |
| Sener, G | 5 |
| Yanardag, R | 2 |
| Mahmoud, NM | 1 |
| Elshazly, SM | 1 |
| Hassan, AA | 1 |
| Soliman, E | 1 |
| Mokhtari, B | 1 |
| Høilund-Carlsen, PF | 1 |
| Chodari, L | 1 |
| Yasami, M | 1 |
| Badalzadeh, R | 1 |
| Ghaffari, S | 1 |
| Reda, S | 1 |
| Elsammak, GA | 1 |
| Elsayed, TG | 1 |
| Mostafa, SA | 1 |
| Atacak, A | 1 |
| Baltaci, SB | 3 |
| Song, Z | 1 |
| Yan, C | 1 |
| Zhan, Y | 1 |
| Wang, Q | 3 |
| Zhang, Y | 1 |
| Jiang, T | 2 |
| Alaa, H | 1 |
| Abdelaziz, M | 1 |
| Mustafa, M | 1 |
| Mansour, M | 1 |
| Magdy, S | 1 |
| Mohsen, S | 1 |
| El-Karamany, Y | 1 |
| Farid, A | 1 |
| An, S | 1 |
| Nedumaran, B | 1 |
| Koh, H | 1 |
| Joo, DJ | 1 |
| Lee, H | 1 |
| Park, CS | 1 |
| Harris, RA | 1 |
| Shin, KS | 1 |
| Djalilian, AR | 1 |
| Kim, YD | 1 |
| Luo, N | 1 |
| Ma, Y | 1 |
| Liu, Z | 3 |
| Esmaie, EM | 1 |
| Abo-Youssef, AM | 1 |
| Tohamy, MA | 1 |
| Kamsrijai, U | 1 |
| Wongchitrat, P | 1 |
| Nopparat, C | 1 |
| Satayavivad, J | 1 |
| Govitrapong, P | 1 |
| Ergenc, M | 1 |
| Ozacmak, HS | 1 |
| Turan, I | 1 |
| Ozacmak, VH | 1 |
| Park, JH | 1 |
| Seo, I | 1 |
| Shim, HM | 1 |
| Cho, H | 1 |
| Che, H | 2 |
| Li, H | 2 |
| Sahil, A | 1 |
| Lv, J | 1 |
| Yang, Z | 1 |
| Dong, R | 1 |
| Xue, H | 1 |
| Wang, L | 2 |
| Maher, AM | 1 |
| Saleh, SR | 1 |
| Elguindy, NM | 1 |
| Hashem, HM | 1 |
| Yacout, GA | 1 |
| Lu, L | 2 |
| Ma, J | 1 |
| Sun, M | 1 |
| Wang, X | 3 |
| Gao, E | 1 |
| Ren, J | 2 |
| Yang, L | 1 |
| Yang, J | 2 |
| Fan, Z | 1 |
| Qi, X | 1 |
| Yang, W | 1 |
| Xia, L | 1 |
| Wu, Y | 1 |
| Sahan, A | 1 |
| Akbal, C | 1 |
| Tavukcu, HH | 1 |
| Cevik, O | 1 |
| Cetinel, S | 1 |
| Sekerci, CA | 1 |
| Sener, TE | 1 |
| Tanidir, Y | 1 |
| Sutradhar, S | 1 |
| Deb, A | 1 |
| Singh, SS | 1 |
| Ferreira de Melo, IM | 1 |
| Martins Ferreira, CG | 1 |
| Lima da Silva Souza, EH | 1 |
| Almeida, LL | 1 |
| Bezerra de Sá, F | 1 |
| Cavalcanti Lapa Neto, CJ | 1 |
| Paz de Castro, MV | 1 |
| Teixeira, VW | 1 |
| Coelho Teixeira, ÁA | 1 |
| Silva, MVD | 1 |
| Vieira Filho, LD | 1 |
| Silva Junior, VAD | 1 |
| Melo, IMF | 1 |
| Santos, LCDS | 1 |
| Yaremii, I | 1 |
| Kushnir, O | 1 |
| Vepriuk, Y | 1 |
| Palamar, A | 1 |
| Skrynchuk, O | 1 |
| Lopes Rocha Correa, V | 1 |
| Assis Martins, J | 1 |
| Ribeiro de Souza, T | 1 |
| de Castro Nunes Rincon, G | 1 |
| Pacheco Miguel, M | 1 |
| Borges de Menezes, L | 1 |
| Correa Amaral, A | 1 |
| Wang, YQ | 1 |
| Yang, ZY | 1 |
| Wang, RL | 1 |
| Wang, LH | 1 |
| Yu, LM | 1 |
| Dong, X | 2 |
| Xue, XD | 1 |
| Xu, S | 2 |
| Zhang, X | 3 |
| Xu, YL | 1 |
| Wang, ZS | 1 |
| Gao, H | 1 |
| Liang, YX | 1 |
| Yang, Y | 3 |
| Wang, HS | 1 |
| Albazal, A | 1 |
| Delshad, AA | 1 |
| Roghani, M | 1 |
| Rahbarghazi, A | 1 |
| Siahkouhian, M | 1 |
| Rahbarghazi, R | 1 |
| Ahmadi, M | 1 |
| Bolboli, L | 1 |
| Mahdipour, M | 1 |
| Haghighi, L | 1 |
| Hassanpour, M | 1 |
| Sokouti Nasimi, F | 1 |
| Keyhanmanesh, R | 1 |
| Li, T | 1 |
| Ma, B | 1 |
| Zhao, Z | 1 |
| Ni, L | 1 |
| Zhang, R | 1 |
| Niu, S | 1 |
| Liu, C | 1 |
| Cui, Y | 1 |
| Yang, M | 1 |
| Lin, P | 1 |
| Cui, C | 1 |
| Song, J | 1 |
| He, Q | 1 |
| Hu, H | 1 |
| Wang, K | 1 |
| Sun, Y | 1 |
| Bostancıeri, N | 1 |
| Elbe, H | 3 |
| Eşrefoğlu, M | 4 |
| Vardı, N | 4 |
| Li, B | 2 |
| Özçelik, F | 1 |
| Hacımustafaoğlu, F | 1 |
| Tanoğlu, A | 1 |
| Lledó, VE | 1 |
| Alkozi, HA | 1 |
| Sánchez-Naves, J | 1 |
| Fernandez-Torres, MA | 1 |
| Guzman-Aranguez, A | 1 |
| Ren, BC | 1 |
| Zhang, W | 2 |
| Ma, JX | 1 |
| Pei, F | 1 |
| Chao, ML | 1 |
| Luo, S | 1 |
| Zhang, C | 1 |
| Zhou, X | 1 |
| Zhou, M | 1 |
| Wang, J | 4 |
| Kong, C | 1 |
| Chen, J | 1 |
| Lin, Z | 1 |
| Tang, X | 2 |
| Sun, S | 1 |
| Chen, H | 1 |
| Wang, H | 3 |
| Wang, D | 1 |
| Sun, JP | 1 |
| Han, Y | 1 |
| Xie, L | 1 |
| Ji, Y | 1 |
| Rebai, R | 1 |
| Jasmin, L | 1 |
| Boudah, A | 1 |
| Şekeroğlu, MR | 1 |
| Huyut, Z | 1 |
| Çokluk, E | 1 |
| Özbek, H | 1 |
| Alp, HH | 1 |
| Gobbo, MG | 3 |
| Tamarindo, GH | 1 |
| Ribeiro, DL | 1 |
| de Campos, SGP | 1 |
| Taboga, SR | 2 |
| Góes, RM | 3 |
| Mehrzadi, S | 1 |
| Motevalian, M | 1 |
| Rezaei Kanavi, M | 1 |
| Fatemi, I | 1 |
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| de Proença, ARG | 1 |
| Vasconcelos, RP | 1 |
| Oliveira, KA | 1 |
| Coelho-de-Souza, AN | 1 |
| Donato-Junior, J | 1 |
| Lima, FB | 2 |
| Bicer, M | 4 |
| Patlar, S | 1 |
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3 reviews available for melatonin and Alloxan Diabetes
| Article | Year |
|---|---|
Renal Protective Effects of Melatonin in Animal Models of Diabetes Mellitus-Related Kidney Damage: A Systematic Review and Meta-Analysis.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Melatonin; M | 2022 |
Melatonin prevents deterioration of erectile function in streptozotocin-induced diabetic rats via sirtuin-1 expression.
Topics: Animals; Diabetes Mellitus, Experimental; Erectile Dysfunction; Humans; Male; Melatonin; Nitric Oxid | 2020 |
Experimental and clinical aspects of melatonin and clock genes in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gluc | 2015 |
178 other studies available for melatonin and Alloxan Diabetes
| Article | Year |
|---|---|
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.
Topics: Acetates; Aldehyde Reductase; Animals; Antioxidants; Diabetes Mellitus, Experimental; Disease Models | 2011 |
The role of the adipose tissue-derived mesenchymal stem cells enriched with melatonin in pancreatic cellular regeneration.
Topics: Animals; Blood Glucose; Body Weight; Caspase 3; Diabetes Mellitus, Experimental; Insulin; Insulin-Se | 2022 |
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
Topics: Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2021 |
Coadministration of Melatonin and Insulin Improves Diabetes-Induced Impairment of Rat Kidney Function.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Kidney; Melatonin; O | 2022 |
Melatonin ameliorates cerebral ischemia-reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1-BMAL1 pathway.
Topics: Animals; Antioxidants; ARNTL Transcription Factors; Autophagy; Brain Ischemia; Diabetes Mellitus, Ex | 2021 |
Melatonin Administration Prevents Placental and Fetal Changes Induced by Gestational Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; Fetus; Humans; Melatonin; P | 2022 |
The effect of vitamin D and melatonin on the ocular tissues in streptozotocin - Induced diabetes model in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Humans; Male; Melatonin; Rats; Rats | 2022 |
Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function.
Topics: Animals; Diabetes Mellitus, Experimental; Meiosis; Melatonin; Mice; Mitochondria; Oocytes; Reactive | 2022 |
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Glucose; Hyperglycemia; Ley | 2022 |
Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Melatonin; Rats; Rats, Wistar; Skin; Soft Tissue | 2022 |
Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelial Progenitor Cells; Hindlimb; Humans; Hydrogen P | 2022 |
Melatonin prevents diabetes-induced nephropathy by modulating the AMPK/SIRT1 axis: Focus on autophagy and mitochondrial dysfunction.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2022 |
The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Melatonin; Peroxisome Proliferator- | 2023 |
The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Melatonin; Peroxisome Proliferator- | 2023 |
The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Melatonin; Peroxisome Proliferator- | 2023 |
The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Melatonin; Peroxisome Proliferator- | 2023 |
The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Glycoproteins; Insulins; Liver; Male; Melato | 2023 |
The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Glycoproteins; Insulins; Liver; Male; Melato | 2023 |
The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Glycoproteins; Insulins; Liver; Male; Melato | 2023 |
The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Glycoproteins; Insulins; Liver; Male; Melato | 2023 |
Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Experimental; D | 2023 |
Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Infarction; Ischemia; Male; Mel | 2023 |
A comparative study between the possible protective role of melatonin versus its combination with adipose derived-mesenchymal stem cells on experimentally induced diabetic retinopathy in adult male albino rats (Histological and immunohistochemical study).
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Melatonin; Mesenchymal Stem Ce | 2023 |
Melatonin protects retinal tissue damage in streptozotocin-induced aged rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Female; Humans; Melatonin; Oxidative Stress; | 2023 |
The effects of resveratrol and melatonin on cardiac dysfunction in diabetic elderly female rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Heart Diseases; Melatonin; Papillary Muscles; Rats | 2023 |
Melatonin attenuates lung ischemia-reperfusion injury through SIRT3 signaling-dependent mitophagy in type 2 diabetic rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Lung; Melatonin; Mit | 2023 |
Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Humans; Hyperglycem | 2023 |
Enhancement of the SESN2-SHP cascade by melatonin ameliorates hepatic gluconeogenesis by inhibiting the CRBN-BTG2-CREBH signaling pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Glu | 2023 |
Melatonin alleviates renal injury in diabetic rats by regulating autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2023 |
Antidiabetic and antioxidant effects of tannic acid and melatonin on streptozotocin induced diabetes in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glyco | 2019 |
Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats.
Topics: Alzheimer Disease; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Mo | 2020 |
Melatonin reverses depressive and anxiety like-behaviours induced by diabetes: involvement of oxidative stress, age, rage and S100B levels in the hippocampus and prefrontal cortex of rats.
Topics: Animals; Anxiety; Depression; Diabetes Mellitus, Experimental; Hippocampus; Malondialdehyde; Melaton | 2022 |
Melatonin and insulin modulates the cellular biochemistry, histoarchitecture and receptor expression during hepatic injury in diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Hepatocytes; Insulin; Lipid P | 2019 |
Melatonin ameliorates SGLT2 inhibitor-induced diabetic ketoacidosis by inhibiting lipolysis and hepatic ketogenesis in type 2 diabetic mice.
Topics: Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic | 2020 |
Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Gene Ex | 2020 |
Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression.
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Diabetes Mellitus, | 2020 |
Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.
Topics: Animals; Anisomycin; Apoptosis; Cell Hypoxia; Cell Line; Cytoprotection; Diabetes Mellitus, Experime | 2020 |
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Topics: Animals; Central Nervous System Depressants; Diabetes Mellitus, Experimental; Diabetic Nephropathies | 2020 |
Melatonin attenuates diabetes-induced oxidative stress in spleen and suppression of splenocyte proliferation in laboratory mice.
Topics: Animals; Antioxidants; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Melatonin | 2022 |
Melatonin regulates the expression of inflammatory cytokines, VEGF and apoptosis in diabetic retinopathy in rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Interleukin-6; Melatonin; | 2020 |
Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Lipid Peroxidation; Male; Melat | 2020 |
EFFECT OF MELATONIN INJECTIONS ON THE GLUTATHIONE SYSTEM IN HEART TISSUE OF RATS UNDER EXPERIMENTAL DIABETES.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Glutath | 2020 |
Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats.
Topics: Animals; Biocompatible Materials; Biopsy; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; | 2020 |
Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ-induced diabetic mice.
Topics: Animals; Antioxidants; Autophagy; Autophagy-Related Protein 12; Beclin-1; Brain; Caspase 1; Cell Lin | 2020 |
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2021 |
Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation.
Topics: Acetylcholinesterase; Animals; Antioxidants; Avoidance Learning; Cognitive Dysfunction; Diabetes Mel | 2021 |
Melatonin and prolonged physical activity attenuated the detrimental effects of diabetic condition on murine cardiac tissue.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Connexin 43; Diabetes Mellitus, Experimental; Glutathio | 2021 |
Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway.
Topics: Animals; Carotid Arteries; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Restenosis; | 2021 |
Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Inflammat | 2021 |
Cardioprotective potential of melatonin, quercetin and resveratrol in an experimental model of diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Melatonin; Models, Theoretical; Oxidative St | 2022 |
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.
Topics: Animals; Apoptosis; Brain Edema; Brain Ischemia; Cell Line; Cell Survival; Chromones; Diabetes Melli | 2021 |
Modulatory effect of resveratrol and melatonin on natural killer cell activity and adrenomedullin in diabetic rats.
Topics: Adrenomedullin; Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Interleukin-6; K | 2022 |
Modulation of aqueous humor melatonin levels by yellow-filter and its protective effect on lens.
Topics: Aged; Animals; Aqueous Humor; Cataract; Cell Survival; Diabetes Mellitus, Experimental; Epithelial C | 2021 |
Melatonin attenuates aortic oxidative stress injury and apoptosis in STZ-diabetes rats by Notch1/Hes1 pathway.
Topics: Animals; Antioxidants; Aorta, Thoracic; Apoptosis; Blood Glucose; Cell Survival; Cells, Cultured; Di | 2021 |
S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Atherosclerosis; Cells, Cultured; Cysteine; Diabetes | 2021 |
The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices.
Topics: Animals; Antidepressive Agents; Anxiety; Depression; Diabetes Mellitus, Experimental; Fluoxetine; Gl | 2017 |
The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Erythrocytes; Free Radical S | 2017 |
Pathological lesions and global DNA methylation in rat prostate under streptozotocin-induced diabetes and melatonin supplementation.
Topics: Animals; Antioxidants; Cell Proliferation; Diabetes Complications; Diabetes Mellitus, Experimental; | 2018 |
Protective effect of melatonin in the diabetic rat retina.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; M | 2018 |
Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats.
Topics: Adipose Tissue, White; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combin | 2018 |
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise.
Topics: Animals; Biomarkers; Bone and Bones; Diabetes Mellitus, Experimental; Dietary Supplements; Glutathio | 2018 |
Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Dynamins; Melatonin; | 2018 |
Melatonin therapy for diabetic cardiomyopathy: A mechanism involving Syk-mitochondrial complex I-SERCA pathway.
Topics: Animals; Apoptosis; Calcium; Caspase 9; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; | 2018 |
Melatonin improves the therapeutic role of mesenchymal stem cells in diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Bone Marrow Cells; Cell Proliferation; Cells, Cultured | 2018 |
Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats.
Topics: Animals; Antioxidants; Caspase 3; Catalase; Diabetes Mellitus, Experimental; Glutathione; Immunohist | 2018 |
Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; | 2018 |
[Effects of aerobic exercise combined with melatonin on osteoporosis of type II diabetic rats].
Topics: Animals; Antioxidants; Bone Density; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2017 |
Melatonin improves hyperglycemia induced damages in rat brain.
Topics: Animals; Antioxidants; Brain; Brain Diseases, Metabolic; Diabetes Mellitus, Experimental; Diabetic N | 2018 |
Melatonin Attenuates Endothelial-to-Mesenchymal Transition of Glomerular Endothelial Cells via Regulating miR-497/ROCK in Diabetic Nephropathy.
Topics: Animals; Cell Line; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetic Nephropathi | 2018 |
Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells.
Topics: Adult Germline Stem Cells; Animals; Apoptosis; Cell Differentiation; Diabetes Mellitus, Experimental | 2018 |
Neuroprotective effects of melatonin on erectile dysfunction in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Erectile Dysfunction; Male; Melatonin; Oxida | 2018 |
Potential therapeutic role of melatonin on STZ-induced diabetic central neuropathy: A biochemical, histopathological, immunohistochemical and ultrastructural study.
Topics: Animals; Blood Glucose; Body Weight; Brain; Diabetes Mellitus, Experimental; Immunohistochemistry; I | 2018 |
Effects of Streptozotocin-Induced Diabetes on the Pineal Gland in the Domestic Pig.
Topics: Animals; Biomarkers; Catecholamines; Diabetes Mellitus, Experimental; Melatonin; Pineal Gland; Serot | 2018 |
Melatonin protects endothelial progenitor cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Autophagy; Cells, Cultured; Diabetes Melli | 2018 |
Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Diabetes Mellitus, Experimental; Down-Regulation; | 2019 |
Protective Role of Melatonin in Streptozotocin Induced Pancreatic Damages in Diabetic Wistar Rat.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hyperglycemia; I | 2018 |
Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of rapamycin (mTOR) signaling pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Male; Melatonin; Rats; Rats, Wi | 2019 |
Melatonin Affects Mitochondrial Fission/Fusion Dynamics in the Diabetic Retina.
Topics: Adenosine Triphosphate; Angiography; Animals; Calcium; Diabetes Mellitus, Experimental; Diabetic Ret | 2019 |
EFFECTS OF 7-DAY MELATONIN INTRODUCTION ON THE HYDROGEN SULFIDE PRODUCTION AND GLUTATHIONE SYSTEM IN THE LIVER OF ALLOXAN INDUCED DIABETIC RATS.
Topics: Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione; Hydrogen; Hydrogen Sul | 2019 |
Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Melatonin; Niacinamide; Oxidative Stress; Poly(ADP-r | 2013 |
Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Male; Melatonin; Necrosis; Oxidative St | 2014 |
[Melatonin as a therapeutic factor in gastric ulcer healing under experimental diabetes].
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Gastric Mucosa; Male; Melatonin; Pineal Glan | 2013 |
NADPH oxidase inhibitor, apocynin, improves renal glutathione status in Zucker diabetic fatty rats: a comparison with melatonin.
Topics: Acetophenones; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibito | 2014 |
Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats.
Topics: Animals; Antioxidants; Blood Glucose; Blood Urea Nitrogen; Catalase; Creatinine; Diabetes Mellitus, | 2015 |
Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Cell Survival; Diabetes Mellitus, Experimental; Humans; | 2014 |
Protective effects of vitamins (C and E) and melatonin co-administration on hematological and hepatic functions and oxidative stress in alloxan-induced diabetic rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Blood Gluco | 2014 |
Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Retinopa | 2014 |
Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Creatine Kinase; Cytoprotection; Diabet | 2015 |
Immunohistochemical distribution of leptin in kidney tissues of melatonin treated diabetic rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Immunohistochemistry; Kidney; L | 2015 |
[Aerobic exercise and the effect of melatonin on experimental study on the effects of antioxidant activity in diabetic rats].
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Melatonin; Physical Conditioning, Animal; Ra | 2014 |
Effect of melatonin on element distribution in the liver tissue of diabetic rats subjected to forced exercise.
Topics: Animals; Antioxidants; Calcium; Chromium; Cobalt; Copper; Diabetes Mellitus, Experimental; Dietary S | 2015 |
Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Diabetes Mellitus, Experimental; Humans; Immunohistoch | 2015 |
Melatonin Modulates the Immune System Response and Inflammation in Diabetic Rats Experimentally-Induced by Alloxan.
Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Interleukin-1beta; Male; Melatonin; Rats; Ra | 2016 |
Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.
Topics: Animals; Aorta, Abdominal; Aortic Diseases; Arteriosclerosis; Blood Glucose; Diabetes Mellitus, Expe | 2016 |
Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes.
Topics: Animals; Biomarkers; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glutathione | 2015 |
Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Catalase; Diabetes Complications; Dia | 2015 |
Melatonin and selenium reduce plasma cytokine and brain oxidative stress levels in diabetic rats.
Topics: Animals; Antioxidants; Brain; Cytokines; Diabetes Mellitus, Experimental; Female; Glutathione Peroxi | 2015 |
Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin.
Topics: Animals; Benzamides; Diabetes Mellitus, Experimental; Male; Melatonin; Myocardial Reperfusion Injury | 2015 |
Melatonin prevents neural tube defects in the offspring of diabetic pregnancy.
Topics: Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Female; Hyperglycemia; Melatonin; Mice | 2015 |
Melatonin nephroprotective action in Zucker diabetic fatty rats involves its inhibitory effect on NADPH oxidase.
Topics: Animals; Cell Membrane; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Reg | 2016 |
The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Ligation; Male; Melatonin; Periodontitis; Rats; | 2016 |
The effect of melatonin on oxidative stress and apoptosis in experimental diabetes mellitus-related ovarian injury.
Topics: Animals; Apoptosis; Caspase 3; Diabetes Mellitus, Experimental; Female; Melatonin; NF-kappa B; Ovary | 2016 |
Melatonin and L-carnitin improves endothelial disfunction and oxidative stress in Type 2 diabetic rats.
Topics: Animals; Antioxidants; Carnitine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2016 |
Effects of Melatonin on Oxidative Stress Index and Alveolar Bone Loss in Diabetic Rats With Periodontitis.
Topics: Alveolar Bone Loss; Animals; Antioxidants; Diabetes Mellitus, Experimental; Melatonin; Oxidative Str | 2016 |
Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca
Topics: Animals; Apoptosis; Calcium; Diabetes Mellitus, Experimental; Female; Ganglia, Spinal; Hippocampus; | 2017 |
Melatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stress.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; Interl | 2016 |
Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Extracellular Signal-Regulated | 2016 |
Melatonin intake since weaning ameliorates steroidogenic function and sperm motility of streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epididymis; Male; Melatonin; Rats; Rats, Wi | 2016 |
Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Melatonin; Oxidative Stress; R | 2016 |
The impaired myocardial ischemic tolerance in adult offspring of diabetic pregnancy is restored by maternal melatonin treatment.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Dietary Supplements; Female; Melatonin; Mice; M | 2016 |
Melatonin suppresses autophagy in type 2 diabetic osteoporosis.
Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Male; MAP Ki | 2016 |
Neuroprotective effect of Cucumis melo Var. flexuosus leaf extract on the brains of rats with streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Brain; Caspase 3; Catalase; Cucumis melo; Diabetes Mellitus, Experimental; D | 2017 |
Short-term administration of melatonin or ghrelin on diabetic rats: effects on angiotensin II and vasopressin-induced uterine contractility.
Topics: Angiotensin II; Animals; Diabetes Mellitus, Experimental; Drug Administration Schedule; Female; Ghre | 2017 |
Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; Cytochromes c; Cytosol; Diabe | 2017 |
Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Diabetes Mellitu | 2008 |
Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes.
Topics: Acetylserotonin O-Methyltransferase; Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltr | 2008 |
Protective effects of melatonin and aminoguanidine on the cornea in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Body Weight; Corneal Diseases; Diabetes | 2008 |
Protective effects of melatonin against the damages of neuroendocrine-immune induced by lipopolysaccharide in diabetic rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antioxidants; Corticosterone; Corticotro | 2009 |
Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCzeta-Akt-GSK3beta pathway in hepatic cells.
Topics: Animals; Antioxidants; Blotting, Western; Cell Line, Tumor; Diabetes Mellitus, Experimental; Dietary | 2009 |
Modulatory role of melatonin on superoxide release by spleen macrophages isolated from alloxan-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; In Vitro Techniques; Insulin; Macrophages; Male; Melatonin | 2009 |
Central nervous system complications of diabetes in streptozotocin-induced diabetic rats: a histopathological and immunohistochemical examination.
Topics: Animals; Antioxidants; Brain Chemistry; Central Nervous System Diseases; Cerebellum; Cerebral Cortex | 2009 |
Comparison of vitamin E, L-carnitine and melatonin in ameliorating carbon tetrachloride and diabetes induced hepatic oxidative stress.
Topics: Animals; Antioxidants; Blood Glucose; Carbon Tetrachloride Poisoning; Carnitine; Chemical and Drug I | 2009 |
Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism.
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Glucokinase; Glu | 2010 |
Selenium-vitamin E combination and melatonin modulates diabetes-induced blood oxidative damage and fetal outcomes in pregnant rats.
Topics: Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Drug Combinations; Female; Glutath | 2011 |
The study of melatonin protective activity on pancreatic β-cells under the condition of alloxan-induced diabetes during aging.
Topics: Age Factors; Aging; Animals; Antioxidants; Diabetes Mellitus, Experimental; Insulin-Secreting Cells; | 2010 |
Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin.
Topics: Analysis of Variance; Animals; Collagenases; Diabetes Mellitus, Experimental; Drug Interactions; Gel | 2011 |
Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cytochrome P-450 CYP2E1; Diabetes Mellitus, Experimental; Drug Evaluation, P | 2011 |
Growth assessment of diabetic rat fetuses under the influence of insulin and melatonin: a morphologic study.
Topics: Animals; Crown-Rump Length; Diabetes Mellitus, Experimental; Female; Fetal Development; Fetal Macros | 2010 |
Interactive effects of melatonin, exercise and diabetes on liver glycogen levels.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Dietary Supplements; Disease Models, Animal; | 2011 |
Corrections by melatonin of liver mitochondrial disorders under diabetes and acute intoxication in rats.
Topics: Adenosine Diphosphate; Animals; Carbon Tetrachloride; Diabetes Mellitus, Experimental; Male; Melaton | 2011 |
Early-stage retinal melatonin synthesis impairment in streptozotocin-induced diabetic wistar rats.
Topics: Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltransferase; Cell Survival; Chromatogra | 2011 |
Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2012 |
Melatonin and succinate reduce rat liver mitochondrial dysfunction in diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Kidney; Liver; L | 2011 |
Mobilisation of endothelial progenitor cells: one of the possible mechanisms involved in the chronic administration of melatonin preventing erectile dysfunction in diabetic rats.
Topics: Animals; Antioxidants; Diabetes Complications; Diabetes Mellitus, Experimental; Endothelium, Vascula | 2012 |
Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Ins | 2012 |
Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Drug | 2012 |
Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin-induced diabetic rats: an immunohistochemical study.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Image Processing, Computer-Assisted; Immunohist | 2012 |
The effects of the melatonin treatment on the oxidative stress and apoptosis in diabetic eye and brain.
Topics: Animals; Antioxidants; Brain; Diabetes Mellitus, Experimental; Eye; Immunohistochemistry; Male; Mela | 2012 |
Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats.
Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Male; Melatonin; Oxidative Stress; Rats; Rat | 2013 |
Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise.
Topics: Animals; Diabetes Mellitus, Experimental; Lipid Peroxidation; Liver; Lung; Male; Melatonin; Physical | 2012 |
Melatonin ameliorates oxidative damage in hyperglycemia-induced liver injury.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; DNA Damage; Enzyme-Linked Immun | 2012 |
Effects of melatonin on streptozotocin-induced retina neuronal apoptosis in high blood glucose rat.
Topics: Animals; Apoptosis; Blood Glucose; Caspase 3; Diabetes Mellitus, Experimental; Male; Melatonin; Rats | 2013 |
Antioxidant activity of melatonin in diabetes in relation to the regulation and levels of plasma Cu, Zn, Fe, Mn, and Se in Zucker diabetic fatty rats.
Topics: Animals; Antioxidants; Copper; Diabetes Mellitus, Experimental; Dietary Supplements; Iron; Male; Man | 2013 |
Vascular reactivity in diabetic rats: effect of melatonin.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes | 2002 |
Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme | 2002 |
Effects of melatonin on oxidative-antioxidative status of tissues in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Free Rad | 2003 |
Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Erythrocytes; Garlic; Glutathione Transferas | 2003 |
Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Immunohistochemi | 2003 |
Protective effect of melatonin on beta-cell damage in streptozotocin-induced diabetes in rats.
Topics: Animals; Blood Glucose; Body Mass Index; Diabetes Mellitus, Experimental; Islets of Langerhans; Male | 2003 |
Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Western; Cerebellum; Cerebral Cortex; Diabetes Mellitus, Experimen | 2003 |
Effect of melatonin on vascular reactivity in pancreatectomized rats.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes | 2004 |
Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Dietary Supplements; Glutathione; Male; Mela | 2004 |
Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: beneficial action of melatonin and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Creatinine; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Gluc | 2004 |
Orally administered tryptophan and experimental type 2 diabetes.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus | 2004 |
Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental | 2004 |
Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Glial Fibrillary Acidic Protei | 2004 |
Effect of streptozotocin-induced diabetes on daily expression of per2 and dbp in the heart and liver and melatonin rhythm in the pineal gland of Wistar rat.
Topics: Animals; Cell Cycle Proteins; Circadian Rhythm; Diabetes Mellitus, Experimental; DNA-Binding Protein | 2005 |
Melatonin restores endothelium-dependent relaxation in aortic rings of pancreatectomized rats.
Topics: Acetylcholine; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endotheli | 2005 |
Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Free Radical Scavengers; Glutathione P | 2006 |
Effect of melatonin on phagocytic activity and intracellular free calcium concentration in testicular macrophages from normal and streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Calcium; Diabetes Mellitus, Experimental; Fluorescent Dyes; Fura-2; K | 2005 |
Depression of glucose levels and partial restoration of pancreatic beta-cell damage by melatonin in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Free Radical Scavengers; Image | 2006 |
Melatonin attenuates diabetes-induced oxidative stress in rabbits.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione; Hydroxyl Radica | 2006 |
Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Escape Reaction; Frontal Lobe | 2006 |
Effects of melatonin on streptozotocin-induced diabetic liver injury in rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hyperglycemia; L | 2006 |
Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Lipid Peroxidation; Male | 2006 |
Diabetes induces changes in melatonin concentrations in peripheral tissues of rat.
Topics: Animals; Circadian Rhythm; Corticosterone; Diabetes Mellitus, Experimental; Gastrointestinal Tract; | 2007 |
Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glucosephosphate Dehydrogenas | 2007 |
Protective effects of chronic melatonin treatment against renal ischemia/reperfusion injury in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Kidney Diseases; Lipid Peroxidation; Male; M | 2007 |
Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats.
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Female; Formaldehyde; Guanid | 2007 |
Short-term melatonin treatment improved diabetic nephropathy but did not affect hemorheological changes in diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Blood Vessels; Diabetes Mellitus, Experimental; Dia | 2007 |
Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Eosine Yellowish-(YS); Fluorescent Dyes; Hem | 2008 |
Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster.
Topics: Animals; Blood Glucose; Circadian Rhythm; Cricetinae; Diabetes Mellitus, Experimental; Male; Melaton | 1983 |
Antioxidant activity of melatonin in mice.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Injections, Intraper | 1993 |
Oxidative stress in diabetic rats induced by streptozotocin: protective effects of melatonin.
Topics: Animals; Blood Glucose; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Experimental; Female; Fruc | 1998 |
Melatonin and taurine reduce early glomerulopathy in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diures | 1999 |
Preservation of the antioxidant status in chemically-induced diabetes mellitus by melatonin.
Topics: Administration, Oral; Alloxan; Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Diabetes | 2000 |
Melatonin protects against streptozotocin, but not interleukin-1beta-induced damage of rodent pancreatic beta-cells.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Free Radical Scavengers; Glucose; Hypergl | 2001 |
Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocyte Membrane; Female; | 2001 |
Retinal photoreceptors of Syrian hamsters undergo oxidative stress during streptozotocin-induced diabetes.
Topics: Amidines; Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Cricetinae; Diabetes Melli | 2002 |
Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus.
Topics: Animals; Brain; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Kidney; Lipid Peroxidation; | 2002 |
Melatonin administration affects plasma total sialic acid and lipid peroxidation levels in streptozotocin induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Supplements; Free Rad | 2002 |
Hormonal modulation of pineal melatonin synthesis in rats and Syrian hamsters: effects of streptozotocin-induced diabetes and insulin injections.
Topics: 5-Hydroxytryptophan; Acetylserotonin O-Methyltransferase; Animals; Arylamine N-Acetyltransferase; Cr | 1986 |
Alloxan-induced diabetes and the pineal gland: differential effects on the levels of pineal N-acetylserotonin, pineal melatonin, and serum melatonin.
Topics: Acetylserotonin O-Methyltransferase; Alloxan; Animals; Diabetes Mellitus, Experimental; Male; Melato | 1985 |
[Role of epiphysis in carbohydrate metabolism].
Topics: Adrenalectomy; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus, Expe | 1968 |