melatonin has been researched along with Airflow Obstruction, Chronic in 14 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic airway inflammation is a characteristic feature of chronic obstructive pulmonary disease (COPD)." | 5.48 | Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD. ( He, B; Peng, Z; Qiao, J; Zhang, W, 2018) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 5.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "The episodes of BA or COPD might be associated with elevated levels of oxidative stress." | 5.35 | Antioxidant enzymes and melatonin levels in patients with bronchial asthma and chronic obstructive pulmonary disease during stable and exacerbation periods. ( Akkaya, A; Beydilli, ED; Caliskan, S; Gumral, N; Naziroglu, M; Ongel, K; Ozguner, F; Sutcu, R, 2009) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Dyspnea was improved by melatonin (P=0." | 2.77 | Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study. ( Andrade, GM; Cavalcante, MM; de Bruin, PF; de Bruin, VM; de Matos Cavalcante, AG; Nunes, DM; Pereira, ED, 2012) |
| "Chronic obstructive pulmonary disease (COPD), a progressive respiratory disease, is characterized by the alveolar epithelium injury and persistent airway inflammation." | 2.72 | The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease. ( Dong, J; He, T; Hu, Y; Li, Z; Tong, J; Wang, X; Zhu, J, 2021) |
| "Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality." | 2.55 | Geroprotectors as a therapeutic strategy for COPD - where are we now? ( Białas, AJ; Górski, P; Makowska, J; Miłkowska-Dymanowska, J; Piotrowski, WJ; Wardzynska, A, 2017) |
| "Melatonin treatment also suppressed the CS-exposure-induced upregulation of cytokine and matrix metalloproteinase (MMP)-9, reduced the PDE4B expression, and elevated cAMP levels." | 1.62 | The Involvement of PDE4 in the Protective Effects of Melatonin on Cigarette-Smoke-Induced Chronic Obstructive Pulmonary Disease. ( Cho, YK; Kim, JC; Kim, JS; Kim, WI; Lee, SJ; Lim, JO; Pak, SW; Shin, IS, 2021) |
| "Melatonin-treated mice exhibited an enhancement in SIRT1 expression with the reduction in p65 acetylation, which decreased the level of inflammatory mediators induced by CS." | 1.56 | Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke. ( Kim, JC; Kim, JS; Kim, MS; Kim, SH; Ko, JW; Park, G; Shin, IS; Shin, NR, 2020) |
| "In recent decades, the occurrence of chronic obstructive pulmonary disease (COPD) has been increased remarkably in the population." | 1.56 | Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice. ( Dutta, S; Mahalanobish, S; Saha, S; Sil, PC, 2020) |
| "Chronic airway inflammation is a characteristic feature of chronic obstructive pulmonary disease (COPD)." | 1.48 | Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD. ( He, B; Peng, Z; Qiao, J; Zhang, W, 2018) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 1.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "Melatonin treatment significantly reduced the mRNA and protein levels of MUC5AC and reduced interleukin (IL)-6 production in EGF-stimulated H292 cells." | 1.40 | Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells. ( Ahn, KS; Jeon, CM; Kim, HS; Kim, JC; Kwon, OK; Lee, MY; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014) |
| "The episodes of BA or COPD might be associated with elevated levels of oxidative stress." | 1.35 | Antioxidant enzymes and melatonin levels in patients with bronchial asthma and chronic obstructive pulmonary disease during stable and exacerbation periods. ( Akkaya, A; Beydilli, ED; Caliskan, S; Gumral, N; Naziroglu, M; Ongel, K; Ozguner, F; Sutcu, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 7 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, Y | 1 |
| He, T | 1 |
| Zhu, J | 1 |
| Wang, X | 1 |
| Tong, J | 1 |
| Li, Z | 1 |
| Dong, J | 1 |
| Lim, JO | 1 |
| Kim, WI | 1 |
| Lee, SJ | 1 |
| Pak, SW | 1 |
| Cho, YK | 1 |
| Kim, JC | 4 |
| Kim, JS | 3 |
| Shin, IS | 4 |
| Zilli Vieira, CL | 1 |
| Koutrakis, P | 1 |
| Liu, M | 1 |
| Gottlieb, DJ | 1 |
| Garshick, E | 1 |
| Shin, NR | 3 |
| Ko, JW | 1 |
| Park, G | 1 |
| Kim, SH | 1 |
| Kim, MS | 1 |
| Mahalanobish, S | 1 |
| Dutta, S | 1 |
| Saha, S | 1 |
| Sil, PC | 1 |
| Mao, K | 1 |
| Luo, P | 1 |
| Geng, W | 1 |
| Xu, J | 1 |
| Liao, Y | 1 |
| Zhong, H | 1 |
| Ma, P | 1 |
| Tan, Q | 1 |
| Xia, H | 1 |
| Duan, L | 1 |
| Song, S | 1 |
| Long, D | 1 |
| Liu, Y | 1 |
| Yang, T | 1 |
| Wu, Y | 1 |
| Jin, Y | 1 |
| Miłkowska-Dymanowska, J | 1 |
| Białas, AJ | 1 |
| Makowska, J | 1 |
| Wardzynska, A | 1 |
| Górski, P | 1 |
| Piotrowski, WJ | 1 |
| Peng, Z | 2 |
| Zhang, W | 2 |
| Qiao, J | 2 |
| He, B | 2 |
| Chai, X | 1 |
| Park, JW | 2 |
| Jeon, CM | 2 |
| Kwon, OK | 2 |
| Lee, MY | 1 |
| Kim, HS | 1 |
| Oh, SR | 2 |
| Ahn, KS | 2 |
| Hong, JM | 1 |
| Lee, IC | 1 |
| Gumral, N | 1 |
| Naziroglu, M | 1 |
| Ongel, K | 1 |
| Beydilli, ED | 1 |
| Ozguner, F | 1 |
| Sutcu, R | 1 |
| Caliskan, S | 1 |
| Akkaya, A | 1 |
| de Matos Cavalcante, AG | 1 |
| de Bruin, PF | 1 |
| de Bruin, VM | 1 |
| Nunes, DM | 1 |
| Pereira, ED | 1 |
| Cavalcante, MM | 1 |
| Andrade, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432] | Phase 2 | 40 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for melatonin and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease.
Topics: Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; CCAAT-Enhancer-Bind | 2021 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Geroprotectors as a therapeutic strategy for COPD - where are we now?
Topics: Aging; Disease Progression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Me | 2017 |
2 trials available for melatonin and Airflow Obstruction, Chronic
10 other studies available for melatonin and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
The Involvement of PDE4 in the Protective Effects of Melatonin on Cigarette-Smoke-Induced Chronic Obstructive Pulmonary Disease.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cigarette Smoking; Humans; Melatonin; Phosphodiesterase 4 Inhib | 2021 |
Intense solar activity reduces urinary 6-sulfatoxymelatonin in patients with COPD.
Topics: Circadian Rhythm; Humans; Melatonin; Obesity; Pulmonary Disease, Chronic Obstructive; Solar Activity | 2023 |
Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke.
Topics: Acetylation; Animals; Antioxidants; Gene Expression Regulation; Inflammation; Inflammation Mediators | 2020 |
Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice.
Topics: Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum | 2020 |
An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis.
Topics: Animals; Biomarkers; Case-Control Studies; Disease Models, Animal; Disease Progression; Female; Gene | 2021 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-1beta; Male; Melatonin; NL | 2018 |
Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats.
Topics: Animals; Apoptosis; Endoplasmic Reticulum Stress; Lung; Male; Melatonin; Oxidative Stress; Pulmonary | 2019 |
Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells.
Topics: Animals; Asthma; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expressi | 2014 |
Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.
Topics: Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Extracellular Signal-Regulated MAP | 2015 |
Antioxidant enzymes and melatonin levels in patients with bronchial asthma and chronic obstructive pulmonary disease during stable and exacerbation periods.
Topics: Antioxidants; Asthma; Catalase; Disease Progression; Glutathione Peroxidase; Glutathione Reductase; | 2009 |