Page last updated: 2024-10-19

melatonin and Aggression

melatonin has been researched along with Aggression in 32 studies

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"In a double-blind, randomized, placebo-controlled between-participant design, 63 healthy male volunteers completed the Taylor Aggression Paradigm (TAP) after oral administration of melatonin or placebo."9.24Melatonin increases reactive aggression in humans. ( Eisenegger, C; Liu, H; Liu, J; Xiong, W; Zhong, R; Zhou, X, 2017)
"The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia."9.09Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study. ( Cats, Q; Haffmans, PM; Lucius, SA; Sival, RC; van Gelder, L, 2001)
"Aggression is one of the symptoms of methamphetamine (MA) use and withdrawal, which can exacerbate MA addiction and relapse."7.91Melatonin pretreatment attenuates acute methamphetamine-induced aggression in male ICR mice. ( Chen, J; Li, S; Wang, X; Wang, Y; Wang, Z; Zhai, H, 2019)
" Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)."7.75We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009)
"The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia."5.09Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study. ( Cats, Q; Haffmans, PM; Lucius, SA; Sival, RC; van Gelder, L, 2001)
"The purpose of this manuscript is to review the evidence generated by clinical trials of pharmaceuticals in autism spectrum disorder (ASD), describe challenges in the conduct of such trials, and discuss future directions RECENT FINDINGS: Clinical trials in ASD have produced several compounds to adequately support the pharmacological treatment of associated symptom domains: attention deficit hyperactivity disorder (methylphenidate, atomoxetine, and alpha agonists), irritability/aggression (risperidone and aripiprazole), sleep (melatonin), and weight gain associated with atypical antipsychotic use (metformin)."4.98Clinical trials in autism spectrum disorder: evidence, challenges and future directions. ( Anagnostou, E, 2018)
" Our previous work suggests that seasonal changes in melatonin secretion are important in regulating aggression in Siberian hamsters (Phodopus sungorus); it is unclear, however, how melatonin acts via its receptors to modulate seasonal variation in social behavior."4.12Adrenal MT ( Demas, GE; Dutta, S; Jasnow, AM; Munley, KM, 2022)
" While the mechanisms underlying SD increases in aggression are not well understood, previous work from our lab suggests that pineal melatonin (MEL) and the adrenal androgen dehydroepiandrosterone (DHEA) are important in facilitating non-breeding aggression in Siberian hamsters (Phodopus sungorus)."3.96Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters. ( Demas, GE; Deyoe, JE; Munley, KM; Ren, CC, 2020)
"Aggression is one of the symptoms of methamphetamine (MA) use and withdrawal, which can exacerbate MA addiction and relapse."3.91Melatonin pretreatment attenuates acute methamphetamine-induced aggression in male ICR mice. ( Chen, J; Li, S; Wang, X; Wang, Y; Wang, Z; Zhai, H, 2019)
" Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)."3.75We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009)
"Melatonin is a hormone that can modulate aggressive interactions in fish, stimulate antioxidant enzymes, and neutralize the biological damage caused by high free radical production."2.94Melatonin reduces aggressiveness and improves oxidative status of matrinxã (Brycon amazonicus) subjected to social challenge. ( Carvalho, TB; da Silva, ECC; de Amaral, AP, 2020)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19908 (25.00)18.7374
1990's1 (3.13)18.2507
2000's6 (18.75)29.6817
2010's6 (18.75)24.3611
2020's11 (34.38)2.80

Authors

AuthorsStudies
Starr, KE1
Burns, K1
Demler, TL1
Munley, KM7
Dutta, S1
Jasnow, AM3
Demas, GE11
Paribello, P1
Manchia, M1
Bosia, M1
Pinna, F1
Carpiniello, B1
Comai, S1
Han, Y1
Lansing, MX1
Trinidad, JC2
Sinkiewicz, DM1
Szwed, SM1
Deyoe, JE2
Ren, CC2
de Amaral, AP1
da Silva, ECC1
Carvalho, TB1
Bui Thi, NH1
Nguyen Thi, NA1
Audira, G1
Siregar, P1
Liang, ST1
Huang, JC1
Hsiao, CD1
Rendon, NM2
Petersen, CL1
Amez, AC1
Boyes, DL1
Kingsbury, MA1
Adaniya, CH1
Nowakowski, AM1
Murphy, GV1
Reinhart, JM1
Liu, J1
Zhong, R1
Xiong, W1
Liu, H1
Eisenegger, C1
Zhou, X1
Anagnostou, E1
Wang, Y1
Wang, X1
Chen, J1
Li, S1
Zhai, H1
Wang, Z1
Cooper, EL1
Ngo, KT1
Laredo, SA1
Orr, VN1
McMackin, MZ1
Trainor, BC1
Rudolph, LM1
Sengelaub, DR1
Ashkenazy, T1
Einat, H1
Kronfeld-Schor, N1
Huhman, KL1
Bartness, TJ1
Polacek, KM1
Durazzo, A1
Lepage, O1
Larson, ET1
Mayer, I1
Winberg, S1
Soma, KK1
Scotti, MA1
Newman, AE1
Charlier, TD1
Paterson, AT3
Vickers, C2
Rickerby, J2
Simpson, J2
Lincoln, GA1
Clarke, IJ1
Haffmans, PM1
Sival, RC1
Lucius, SA1
Cats, Q1
van Gelder, L1
Badura, LL1
Nunez, AA1
Heinzeller, T1
Joshi, BN1
Nürnberger, F1
Reiter, RJ1
Fleming, AS1
Phillips, A1
Rydall, A1
Levesque, L1
Munro, AD1
Clare, AW1

Reviews

4 reviews available for melatonin and Aggression

ArticleYear
Melatonin and aggressive behavior: A systematic review of the literature on preclinical and clinical evidence.
    Journal of pineal research, 2022, Volume: 72, Issue:4

    Topics: Aggression; Animals; Melatonin; Violence

2022
Winter madness: Melatonin as a neuroendocrine regulator of seasonal aggression.
    Journal of experimental zoology. Part A, Ecological and integrative physiology, 2022, Volume: 337, Issue:9-10

    Topics: Aggression; Animals; Cricetinae; Melatonin; Phodopus; Photoperiod; Seasons

2022
Clinical trials in autism spectrum disorder: evidence, challenges and future directions.
    Current opinion in neurology, 2018, Volume: 31, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aggression; Antipsychotic Agents; Aripipraz

2018
Novel mechanisms for neuroendocrine regulation of aggression.
    Frontiers in neuroendocrinology, 2008, Volume: 29, Issue:4

    Topics: Adrenal Glands; Aggression; Animals; Behavior, Animal; Brain; Dehydroepiandrosterone; Humans; Melato

2008

Trials

3 trials available for melatonin and Aggression

ArticleYear
Melatonin reduces aggressiveness and improves oxidative status of matrinxã (Brycon amazonicus) subjected to social challenge.
    Fish physiology and biochemistry, 2020, Volume: 46, Issue:3

    Topics: Aggression; Animals; Antioxidants; Aquaculture; Behavior, Animal; Characiformes; Melatonin; Oxidativ

2020
Melatonin increases reactive aggression in humans.
    Psychopharmacology, 2017, Volume: 234, Issue:19

    Topics: Administration, Oral; Adult; Aggression; Animals; Central Nervous System Depressants; Circadian Rhyt

2017
Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study.
    International journal of geriatric psychiatry, 2001, Volume: 16, Issue:1

    Topics: Aged; Aggression; Anticonvulsants; Combined Modality Therapy; Cross-Over Studies; Dementia; Double-B

2001

Other Studies

25 other studies available for melatonin and Aggression

ArticleYear
Pharmacological and philosophical considerations for the around-the-clock use of scheduled melatonin to promote sedation and reduce aggression in individuals with serious mental illness: a case report.
    International clinical psychopharmacology, 2021, 11-01, Volume: 36, Issue:6

    Topics: Aggression; Drug Administration Schedule; Duration of Therapy; Humans; Melatonin; Mental Disorders;

2021
Adrenal MT
    Hormones and behavior, 2022, Volume: 138

    Topics: Aggression; Animals; Body Weight; Cricetinae; Male; Melatonin; Phodopus; Photoperiod; Receptors, Mel

2022
Sex-specific endocrine regulation of seasonal aggression in Siberian hamsters.
    Proceedings. Biological sciences, 2022, 09-14, Volume: 289, Issue:1982

    Topics: Aggression; Animals; Cricetinae; Dehydroepiandrosterone; Female; Male; Melatonin; Phodopus; Seasons

2022
Sex and seasonal differences in neural steroid sensitivity predict territorial aggression in Siberian hamsters.
    Hormones and behavior, 2023, Volume: 154

    Topics: Aggression; Animals; Cricetinae; Female; Male; Melatonin; Phodopus; Photoperiod; Seasons; Steroids

2023
Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters.
    Hormones and behavior, 2020, Volume: 117

    Topics: Aggression; Androgens; Animals; Behavior, Animal; Cricetinae; Gonadal Dysgenesis, 46,XY; Male; Melat

2020
Chronic Exposure to Low Concentration Lead Chloride-Induced Anxiety and Loss of Aggression and Memory in Zebrafish.
    International journal of molecular sciences, 2020, Mar-07, Volume: 21, Issue:5

    Topics: Aggression; Animals; Anxiety; Behavior, Animal; Ecotoxicology; Environmental Exposure; Hydrocortison

2020
Seasonal patterns of melatonin alter aggressive phenotypes of female Siberian hamsters.
    Journal of neuroendocrinology, 2020, Volume: 32, Issue:8

    Topics: Aggression; Animals; Cricetinae; Female; Melatonin; Phenotype; Phodopus; Photoperiod; Reproduction;

2020
Melatonin-dependent changes in neurosteroids are associated with increased aggression in a seasonally breeding rodent.
    Journal of neuroendocrinology, 2021, Volume: 33, Issue:3

    Topics: Aggression; Animals; Brain Chemistry; Gonadal Steroid Hormones; Injections, Subcutaneous; Male; Mela

2021
Melatonin pretreatment attenuates acute methamphetamine-induced aggression in male ICR mice.
    Brain research, 2019, 07-15, Volume: 1715

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Brain; Dopamine; Homovanillic Acid; Hydroxyindo

2019
A short note on how tied fights affect cortisol levels.
    Integrative zoology, 2013, Volume: 8, Issue:3

    Topics: Aggression; Animals; Enzyme-Linked Immunosorbent Assay; Hydrocortisone; Melatonin; Social Behavior;

2013
The effects of exogenous melatonin and melatonin receptor blockade on aggression and estrogen-dependent gene expression in male California mice (Peromyscus californicus).
    Physiology & behavior, 2014, Apr-10, Volume: 128

    Topics: Aggression; Animals; Estrogen Receptor alpha; Estrogens; Gene Expression Regulation; Letrozole; Male

2014
The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens.
    Proceedings. Biological sciences, 2015, Nov-22, Volume: 282, Issue:1819

    Topics: Adrenal Glands; Aggression; Animals; Dehydroepiandrosterone; Female; Melatonin; Phodopus; Photoperio

2015
We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections.
    The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:1

    Topics: Aggression; Animals; Anxiety; Body Weight; Data Interpretation, Statistical; Depression; Food Prefer

2009
Short days and exogenous melatonin increase aggression of male Syrian hamsters (Mesocricetus auratus).
    Hormones and behavior, 2002, Volume: 42, Issue:1

    Topics: Aggression; Animals; Cricetinae; Male; Melatonin; Mesocricetus; Photoperiod; Reference Values

2002
Adrenal hormones mediate melatonin-induced increases in aggression in male Siberian hamsters (Phodopus sungorus).
    Hormones and behavior, 2004, Volume: 46, Issue:5

    Topics: Adaptation, Physiological; Adrenal Cortex; Adrenal Medulla; Adrenalectomy; Aggression; Animals; Cric

2004
Serotonin, but not melatonin, plays a role in shaping dominant-subordinate relationships and aggression in rainbow trout.
    Hormones and behavior, 2005, Volume: 48, Issue:2

    Topics: Aggression; Animals; Citalopram; Diet; Dominance-Subordination; Drug Implants; Female; Hydrocortison

2005
Melatonin and the adrenal cortex: relationship to territorial aggression in mice.
    Physiology & behavior, 1981, Volume: 27, Issue:6

    Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aggression; Animals; Humans; M

1981
Possible interaction of melanocyte-stimulating hormone (MSH) and the pineal in the control of territorial aggression in mice.
    Physiology & behavior, 1980, Volume: 24, Issue:5

    Topics: Aggression; Animals; Behavior, Animal; Humans; Male; Melanocyte-Stimulating Hormones; Melatonin; Mic

1980
Photoperiodically-induced cycles in the secretion of prolactin in hypothalamo-pituitary disconnected rams: evidence for translation of the melatonin signal in the pituitary gland.
    Journal of neuroendocrinology, 1994, Volume: 6, Issue:3

    Topics: Aggression; Animals; Catheterization; Circadian Rhythm; Eating; Hair; Hypothalamo-Hypophyseal System

1994
Pineal facilitation of territorial aggression [proceedings].
    The Journal of physiology, 1978, Volume: 284

    Topics: Aggression; Animals; Humans; Male; Melatonin; Mice; Pineal Gland; Territoriality

1978
Photoperiodic modulation of sexual and aggressive behavior in female golden hamsters (Mesocricetus auratus): role of the pineal gland.
    Hormones and behavior, 1989, Volume: 23, Issue:1

    Topics: Aggression; Animals; Circadian Rhythm; Cricetinae; Estradiol; Estrus; Female; Light; Melatonin; Meso

1989
Effects of aggressive encounters on pineal melatonin formation in male gerbils (Meriones unguiculatus, Cricetidae).
    Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 1988, Volume: 164, Issue:1

    Topics: Acetyltransferases; Aggression; Animals; Arylamine N-Acetyltransferase; Gerbillinae; Male; Melatonin

1988
Effects of photoperiod, the pineal gland and the gonads on agonistic behavior in female golden hamsters (Mesocricetus auratus).
    Physiology & behavior, 1988, Volume: 44, Issue:2

    Topics: Aggression; Animals; Cricetinae; Estrus; Female; Light; Melatonin; Mesocricetus; Ovariectomy; Ovary;

1988
Effects of melatonin, serotonin, and naloxone on aggression in isolated cichlid fish (Aequidens pulcher).
    Journal of pineal research, 1986, Volume: 3, Issue:3

    Topics: Aggression; Animals; Female; Melatonin; Naloxone; Perches; Perciformes; S-Adenosylhomocysteine; Sero

1986
Hormones, behaviour and the menstrual cycle.
    Journal of psychosomatic research, 1985, Volume: 29, Issue:3

    Topics: Achievement; Affect; Aggression; Androgens; Estrogens; Female; Hormones; Humans; Melatonin; Menstrua

1985