melatonin and Affective Psychosis, Bipolar studies

Research Excerpts

Excerpt	Relevance	Reference
"In this small trial, melatonin did not effectively treat emerging hypomania or mania as there was no significant difference on the primary outcome."	9.41	Melatonin In Acute Mania Investigation (MIAMI-UK). A randomized controlled trial of add-on melatonin in bipolar disorder. ( Ahmad, F; Al-Taiar, H; Cordey, JH; De Crescenzo, F; Economou, A; Geddes, JR; Gibson, JC; Lawson, J; Lennox, A; Quested, DJ; Rendell, JM; Sharpley, AL; Voysey, M, 2021)
" Amelioration of cognitive dysfunction may be facilitated during benzodiazepine tapering by add-on melatonin due to its anti-inflammatory and neuroprotective properties."	9.24	Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo. ( Baandrup, L; Fagerlund, B; Glenthoj, B, 2017)
"We aimed to evaluate melatonin effectiveness in weight gain reduction following olanzapine use for 11-17-year-old bipolar disorder patients."	9.24	Melatonin for Reducing Weight Gain Following Administration of Atypical Antipsychotic Olanzapine for Adolescents with Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Akhondzadeh, S; Mohammadi, MR; Mostafavi, SA; Solhi, M, 2017)
"Melatonin/ramelteon augmentation may be beneficial for non-anthropometric metabolic syndrome components in patients treated with antipsychotics."	9.22	Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic review and meta-analysis. ( Fornaro, M; Miola, A; Sambataro, F; Solmi, M, 2022)
"We assessed if prolonged-release melatonin can facilitate withdrawal of long-term benzodiazepine usage in patients with schizophrenia or bipolar disorder."	9.22	Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia or bipolar disorder: A randomised, placebo-controlled, blinded trial. ( Baandrup, L; Glenthoj, BY; Gluud, C; Lindschou, J; Winkel, P, 2016)
"Olanzapine is the frequently prescribed drug in children and adolescents with bipolar disorder, but unfortunately it has metabolic side-effects."	9.19	Melatonin decreases olanzapine induced metabolic side-effects in adolescents with bipolar disorder: a randomized double-blind placebo-controlled trial. ( Akhondzadeh, S; Hamedi, M; Keshavarzi, M; Mohammadi, MR; Mostafavi, A; Solhi, M, 2014)
"Five patients with rapid-cycling DSM-III-R bipolar disorder were treated with melatonin 10 mg q."	9.08	Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. ( Feldman-Naim, S; Leibenluft, E; Rosenthal, NE; Turner, EH; Wehr, TA, 1997)
"The present study evaluates the effect of exogenous melatonin (exo-MEL) on sleep and circadian parameters in patients with bipolar disorder (BD) and delayed sleep-wake phase disorder (DSWPD)."	8.31	Effects of exogenous melatonin on sleep and circadian rhythm parameters in bipolar disorder with comorbid delayed sleep-wake phase disorder: An actigraphic study. ( Bazzani, A; Bonelli, C; Bruno, S; Carmassi, C; Cruz-Sanabria, F; Dell'Osso, L; Faraguna, U; Frumento, P; Gravina, D; Massoni, L; Musetti, L; Simoncini, M; Violi, M, 2023)
"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."	7.91	Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"Melatonin, which plays an important role for regulation of circadian rhythms and the sleep/wake cycle has been linked to the pathophysiology of major depressive and bipolar disorder."	7.83	Differential melatonin alterations in cerebrospinal fluid and serum of patients with major depressive disorder and bipolar disorder. ( Bumb, JM; Enning, F; Findeisen, P; Leweke, FM; Mueller, JK; Noelte, I; Rohleder, C; Schwarz, E; van der List, T, 2016)
"We examined 24-hour melatonin rhythms from 20 patients with seasonal affective disorder (SAD) and 20 healthy volunteers."	7.68	Melatonin rhythms in seasonal affective disorder. ( Abbas, M; Arendt, J; Checkley, SA; Franey, C; Marks, M; Murphy, DG; Murphy, DM; Palazidou, E; Winton, F, 1993)
" Eligible patients included adults with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder and long-term use of benzodiazepines in combination with antipsychotics."	6.82	Objective and subjective sleep quality: Melatonin versus placebo add-on treatment in patients with schizophrenia or bipolar disorder withdrawing from long-term benzodiazepine use. ( Baandrup, L; Glenthøj, BY; Jennum, PJ, 2016)
"Melatonin is a pineal gland secreted neurohormone that induces circadian-related and sleep-related responses."	6.52	Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. ( Bellivier, F; Etain, B; Franchi, JA; Geoffroy, PA; Ritter, P, 2015)
"Circadian dysregulation has long been thought to be a key component in the pathophysiology of bipolar disorder (BD)."	5.72	Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study. ( Chan, JWY; Chan, NY; Feng, H; Ho, AW; Ho, CS; Lam, SP; Lei, B; Liu, Y; Merikangas, KR; Tsang, JCC; Wang, J; Wing, YK; Zhang, J, 2022)
"In this small trial, melatonin did not effectively treat emerging hypomania or mania as there was no significant difference on the primary outcome."	5.41	Melatonin In Acute Mania Investigation (MIAMI-UK). A randomized controlled trial of add-on melatonin in bipolar disorder. ( Ahmad, F; Al-Taiar, H; Cordey, JH; De Crescenzo, F; Economou, A; Geddes, JR; Gibson, JC; Lawson, J; Lennox, A; Quested, DJ; Rendell, JM; Sharpley, AL; Voysey, M, 2021)
"This is a double-blind, placebo-controlled, parallel-grouped clinical trial, which was designed to investigate the potential effects of melatonin add-on treatment with lithium and risperidone on acute manic episodes in patients with bipolar disorder (BD)."	5.34	Efficacy of melatonin as an adjunct in the treatment of acute mania: a double-blind and placebo-controlled trial. ( Akhondzadeh, S; Bahmani, S; Bayanati, S; Mahdavinasa, M; Moghaddam, HS; Rezaei, F, 2020)
" Amelioration of cognitive dysfunction may be facilitated during benzodiazepine tapering by add-on melatonin due to its anti-inflammatory and neuroprotective properties."	5.24	Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo. ( Baandrup, L; Fagerlund, B; Glenthoj, B, 2017)
"We aimed to evaluate melatonin effectiveness in weight gain reduction following olanzapine use for 11-17-year-old bipolar disorder patients."	5.24	Melatonin for Reducing Weight Gain Following Administration of Atypical Antipsychotic Olanzapine for Adolescents with Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Akhondzadeh, S; Mohammadi, MR; Mostafavi, SA; Solhi, M, 2017)
", light therapy, sleep deprivation, sleep phase advance and dark therapy, pharmacological in the form of melatonin and psychological consisting of interpersonal and social rhythm therapy or cognitive behavioral therapy for insomnia modified for patients with bipolar disorder."	5.22	[Chronotherapy of affective disorders: principles and clinical aspects]. ( Ludwig, VM; Münch, I; Ritter, P; Wirz-Justice, A, 2022)
"Melatonin/ramelteon augmentation may be beneficial for non-anthropometric metabolic syndrome components in patients treated with antipsychotics."	5.22	Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic review and meta-analysis. ( Fornaro, M; Miola, A; Sambataro, F; Solmi, M, 2022)
"We assessed if prolonged-release melatonin can facilitate withdrawal of long-term benzodiazepine usage in patients with schizophrenia or bipolar disorder."	5.22	Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia or bipolar disorder: A randomised, placebo-controlled, blinded trial. ( Baandrup, L; Glenthoj, BY; Gluud, C; Lindschou, J; Winkel, P, 2016)
"Our results show that melatonin is effective in attenuating SGAs' adverse metabolic effects, particularly in bipolar disorder."	5.19	Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial. ( Alvarez-Icaza González, D; Becerra-Palars, C; Berlanga, C; Buijs, RM; Fresán-Orellana, A; Heinze, G; Moreno, J; Ontiveros Uribe, MP; Romo-Nava, F; Saracco Alvarez, R, 2014)
"Olanzapine is the frequently prescribed drug in children and adolescents with bipolar disorder, but unfortunately it has metabolic side-effects."	5.19	Melatonin decreases olanzapine induced metabolic side-effects in adolescents with bipolar disorder: a randomized double-blind placebo-controlled trial. ( Akhondzadeh, S; Hamedi, M; Keshavarzi, M; Mohammadi, MR; Mostafavi, A; Solhi, M, 2014)
"Five patients with rapid-cycling DSM-III-R bipolar disorder were treated with melatonin 10 mg q."	5.08	Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. ( Feldman-Naim, S; Leibenluft, E; Rosenthal, NE; Turner, EH; Wehr, TA, 1997)
"We conducted a review using Medline, ISI Database, EMBase, PsyInfo up to January 2015, using the following keywords combinations: "mood disorder", "bipolar disorder", "depression", "unipolar disorder", "major depressive disorder", "affective disorder", for psychiatric conditions; and "circadian rhythms", "circadian markers", "circadian gene", "clock gene", "melatonin" for circadian rhythms."	4.91	[Circadian markers and genes in bipolar disorder]. ( Belliviera, F; Boudebesse, C; Etain, B; Yeim, S, 2015)
"Several studies support the relationship between bipolar disorder and circadian cycles, discussing alterations in melatonin, body temperature and cortisol rhythms; disruption of sleep/wake cycle; variations of clock genes; and chronotype."	4.91	The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles. ( Abreu, T; Bragança, M, 2015)
"PubMed database was searched systematically for articles that were published on or before May 5, 2013, and were written in English using the terms bipolar disorder, clock genes, endogenous clock, molecular clock, biological rhythms, circadian, suprachiasmatic nucleus, circadian rhythm, melatonin, and sleep."	4.90	The relationship between bipolar disorder and biological rhythms. ( Gonzalez, R, 2014)
"Patients with bipolar disorder show altered rhythmicity in body temperature and melatonin rhythms, high day-to-day variability in activity and sleep timing, persistent disturbances of sleep or wake cycles, including disturbances of sleep continuity."	4.90	Circadian rhythms and sleep in bipolar disorder: implications for pathophysiology and treatment. ( Soreca, I, 2014)
"Bright light treatment is the most potent melatonin suppressor and circadian phase shifter and is a safe nonpharmacologic antidepressant for seasonal depression."	4.82	Circadian phase shifting, alerting, and antidepressant effects of bright light treatment. ( Oren, DA; Postolache, TT, 2005)
"The present study evaluates the effect of exogenous melatonin (exo-MEL) on sleep and circadian parameters in patients with bipolar disorder (BD) and delayed sleep-wake phase disorder (DSWPD)."	4.31	Effects of exogenous melatonin on sleep and circadian rhythm parameters in bipolar disorder with comorbid delayed sleep-wake phase disorder: An actigraphic study. ( Bazzani, A; Bonelli, C; Bruno, S; Carmassi, C; Cruz-Sanabria, F; Dell'Osso, L; Faraguna, U; Frumento, P; Gravina, D; Massoni, L; Musetti, L; Simoncini, M; Violi, M, 2023)
"Circadian rhythm disruption is a core symptom of bipolar disorder (BD), also reflected in altered patterns of melatonin release."	4.31	Melatonin secretion patterns are associated with cognitive vulnerability and brain structure in bipolar depression. ( Benedetti, F; Colombo, C; d'Orsi, G; Dallaspezia, S; Lorenzi, C; Melloni, EMT; Paolini, M; Poletti, S; Yoshiike, T; Zanardi, R, 2023)
"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."	3.91	Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"Melatonin, which plays an important role for regulation of circadian rhythms and the sleep/wake cycle has been linked to the pathophysiology of major depressive and bipolar disorder."	3.83	Differential melatonin alterations in cerebrospinal fluid and serum of patients with major depressive disorder and bipolar disorder. ( Bumb, JM; Enning, F; Findeisen, P; Leweke, FM; Mueller, JK; Noelte, I; Rohleder, C; Schwarz, E; van der List, T, 2016)
" Patients with bipolar disorders had significantly lower levels and later onset of melatonin secretion than those with unipolar depression."	3.79	Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. ( Hermens, DF; Hickie, IB; Ip, TK; Naismith, SL; Robillard, R; Rogers, NL; Scott, EM, 2013)
"In order to investigate melatonin receptors in the SCN during depression, and their relationship to the major neuropeptides in the SCN, vasopressin (AVP) and vasoactive intestinal peptide (VIP), we studied the SCN in 14 depressed patients (five major depression and nine bipolar disorder) and 14 matched controls by immunocytochemistry."	3.79	Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. ( Ai-Min, B; Jockers, R; Scheer, FA; Swaab, DF; Ursinus, J; van Heerikhuize, J; Wu, YH; Zhou, JN, 2013)
"Circadian rhythm instability and abnormalities of melatonin secretion are considered as trait markers of bipolar disorder."	3.77	MRI exploration of pineal volume in bipolar disorder. ( d'Albis, MA; Daban, C; Delavest, M; Etain, B; Hamdani, N; Houenou, J; Leboyer, M; Lépine, JP; Mangin, JF; Poupon, C; Sarrazin, S; Vederine, FE, 2011)
"The super-sensitivity of the neurohormone melatonin to light in patients with bipolar disorder provides evidence of the circadian nature of the disorder."	3.73	The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins. ( Begg, DP; Chambers, V; Hallam, KT; McGrath, C; Norman, TR; Olver, JS, 2006)
"We examined 24-hour melatonin rhythms from 20 patients with seasonal affective disorder (SAD) and 20 healthy volunteers."	3.68	Melatonin rhythms in seasonal affective disorder. ( Abbas, M; Arendt, J; Checkley, SA; Franey, C; Marks, M; Murphy, DG; Murphy, DM; Palazidou, E; Winton, F, 1993)
"Nocturnal melatonin suppression to 500 lux light was studied during an acute episode of illness in 8 patients with bipolar disorder, 7 patients with unipolar depression, and 15 age-, sex-, and season-matched normal controls."	3.68	Melatonin suppression in bipolar and unipolar mood disorders. ( Berga, SL; Berkowitz, AL; Clark, CM; Gillin, JC; Kripke, DF; Lam, RW, 1990)
" Eligible patients included adults with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder and long-term use of benzodiazepines in combination with antipsychotics."	2.82	Objective and subjective sleep quality: Melatonin versus placebo add-on treatment in patients with schizophrenia or bipolar disorder withdrawing from long-term benzodiazepine use. ( Baandrup, L; Glenthøj, BY; Jennum, PJ, 2016)
" Recent meta-analysis suggests that optimal dosage and dosing time might be important to maximize the efficacy of melatonin."	2.82	Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness. ( Kim, K; Linnaranta, O; Moon, E; Partonen, T, 2022)
"Melatonin (MLT) is a main synchronizer of the sleep/wake cycle, playing a role of transduction to brain functioning of informations about periodical environmental changes, i."	2.69	Melatonin add-on in manic patients with treatment resistant insomnia. ( Bersani, G; Garavini, A, 2000)
"We also address whether circadian dysregulation provides vulnerability to onset of BSD and evidence for a new integration of reward and circadian dysregulation in BSD."	2.55	Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders. ( Alloy, LB; Boland, EM; Ng, TH; Titone, MK, 2017)
"Depression was more frequently associated with circadian alterations than euthymia."	2.55	Chronotype and circadian rhythm in bipolar disorder: A systematic review. ( Abreu, RLC; de Bruin, PFC; de Bruin, VMS; Linhares Neto, VB; Melo, MCA, 2017)
"Melatonin is a pineal gland secreted neurohormone that induces circadian-related and sleep-related responses."	2.52	Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. ( Bellivier, F; Etain, B; Franchi, JA; Geoffroy, PA; Ritter, P, 2015)
"Melatonin has few immediate side-effects except drowsiness, but the effects of chronic administration are unclear."	2.40	Guidelines for prescribing melatonin. ( Avery, D; Landis, C; Lenz, M, 1998)
"Sleep deprivation is reported to have therapeutic effectiveness in depressive illness."	2.37	Clinical and biological correlates of sleep deprivation in depression. ( Brown, P; Joffe, RT, 1984)
"Circadian dysregulation has long been thought to be a key component in the pathophysiology of bipolar disorder (BD)."	1.72	Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study. ( Chan, JWY; Chan, NY; Feng, H; Ho, AW; Ho, CS; Lam, SP; Lei, B; Liu, Y; Merikangas, KR; Tsang, JCC; Wang, J; Wing, YK; Zhang, J, 2022)
"Melatonin is a main regulatory hormone for the circadian rhythm."	1.62	Melatonin Receptor Gene Polymorphism in Bipolar-I Disorder. ( Akbaş, H; Bayazıt, H; Karababa, İF; Mulayim, E; Selek, S, 2021)
"Melatonin suppression was assessed in euthymic patients with bipolar I disorder and healthy controls by exposure to monochromatic blue light (λmax = 475 nm; photon density = 1."	1.56	Melatonin suppression by melanopsin-weighted light in patients with bipolar I disorder compared to healthy controls ( Bauer, M; Güldner, H; Neumann, S; Pfennig, A; Ritter, P; Sauer, C; Severus, E; Skene, DJ; Soltmann, B; Weiss, M; Wieland, F, 2020)
"Melatonin treatment (similar to lithium) was also effective in preventing the following alterations elicited by OUA: increase of RS and PC levels; depletion of NPSH levels; increase of SOD activity; and inhibition of CAT and GPx activities."	1.40	The protective effect of melatonin against brain oxidative stress and hyperlocomotion in a rat model of mania induced by ouabain. ( Boeira, SP; Bortolatto, CF; Jesse, CR; Nogueira, CW; Souza, LC; Wilhelm, EA, 2014)
"The melatonin measures were not consistently related to any of the previously reported hypothalamic-pituitary-adrenal cortical axis measures in these subjects."	1.28	Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. ( Hanada, K; Heist, EK; Lesser, IM; McGeoy, SS; Rubin, RT, 1992)
"Melatonin levels were not lower in females than in males, when melatonin levels were adjusted for body height."	1.27	Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. ( Beck-Friis, J; Kjellman, BF; Ljunggren, JG; von Rosen, D; Wetterberg, L, 1984)

Research

Studies (118)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Depressive Symptoms at Baseline and Measured Monthly, as Measured by the Structured Interview Guide for the Hamilton Depression Rating - Seasonal Affective Disorder (SIGH-SAD)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (17.80)	18.7374
1990's	24 (20.34)	18.2507
2000's	15 (12.71)	29.6817
2010's	38 (32.20)	24.3611
2020's	20 (16.95)	2.80

Authors	Studies
Miola, A	1
Fornaro, M	1
Sambataro, F	1
Solmi, M	1
Titone, MK	3
Goel, N	2
Ng, TH	3
MacMullen, LE	2
Alloy, LB	4
McGowan, NM	1
Kim, DS	1
de Andres Crespo, M	1
Bisdounis, L	1
Kyle, SD	1
Saunders, KEA	1
Ludwig, VM	1
Münch, I	1
Wirz-Justice, A	1
Ritter, P	4
Feng, H	1
Ho, AW	1
Lei, B	1
Chan, JWY	1
Wang, J	1
Liu, Y	1
Tsang, JCC	1
Chan, NY	1
Lam, SP	1
Merikangas, KR	1
Ho, CS	1
Zhang, J	1
Wing, YK	1
Moon, E	1
Kim, K	1
Partonen, T	1
Linnaranta, O	1
Lesicka, M	1
Dmitrzak-Weglarz, M	1
Jablonska, E	1
Wieczorek, E	1
Kapelski, P	1
Szczepankiewicz, A	1
Pawlak, J	1
Reszka, E	1
Cruz-Sanabria, F	1
Faraguna, U	1
Violi, M	1
Bruno, S	1
Gravina, D	1
Bonelli, C	1
Bazzani, A	1
Massoni, L	1
Musetti, L	1
Simoncini, M	1
Frumento, P	1
Dell'Osso, L	1
Carmassi, C	1
Walsh, RFL	1
Smith, LT	1
Maddox, MA	1
Olino, TM	1
Zee, PC	1
Nusslock, R	1
Melloni, EMT	1
Paolini, M	1
Dallaspezia, S	2
Lorenzi, C	1
Poletti, S	1
d'Orsi, G	1
Yoshiike, T	1
Zanardi, R	1
Colombo, C	1
Benedetti, F	2
Tassan Mazzocco, M	1
Pisanu, C	1
Russo, L	1
Acconcia, C	1
Cambiaghi, M	1
De Girolamo, S	1
Squassina, A	1
Cherchi, L	1
Monzani, E	1
Scebba, F	1
Angeloni, D	1
De Gregorio, D	1
Nasini, S	1
Dall'Acqua, S	1
Sut, S	1
Suprani, F	1
Garzilli, M	1
Guiso, B	1
Pulcinelli, V	1
Iaselli, MN	1
Pinna, I	1
Somaini, G	1
Arru, L	1
Corrias, C	1
Paribello, P	1
Pinna, F	1
Gobbi, G	1
Valtorta, F	1
Carpiniello, B	1
Manchia, M	1
Comai, S	1
Moghaddam, HS	1
Bahmani, S	1
Bayanati, S	1
Mahdavinasa, M	1
Rezaei, F	1
Akhondzadeh, S	3
Wieland, F	1
Skene, DJ	2
Pfennig, A	1
Weiss, M	1
Bauer, M	1
Severus, E	1
Güldner, H	1
Sauer, C	1
Soltmann, B	1
Neumann, S	1
Quested, DJ	1
Gibson, JC	1
Sharpley, AL	1
Cordey, JH	1
Economou, A	1
De Crescenzo, F	1
Voysey, M	1
Lawson, J	1
Rendell, JM	1
Al-Taiar, H	1
Lennox, A	1
Ahmad, F	1
Geddes, JR	1
Murray, G	1
Gottlieb, J	1
Hidalgo, MP	2
Etain, B	7
Garbazza, C	1
Bullock, B	1
Merikangas, K	1
Zipunnikov, V	1
Shou, H	1
Gonzalez, R	2
Scott, J	1
Geoffroy, PA	5
Frey, BN	3
McArthur, BA	1
Burke, TA	1
McLaughlin, LE	1
Mulayim, E	1
Karababa, İF	1
Akbaş, H	1
Bayazıt, H	1
Selek, S	1
Kishi, T	1
Nishiyama, H	1
Kimura, Y	1
Sadaka, T	1
Terada, A	1
Tatsumi, Y	1
Wakahara, M	1
Iwata, N	1
Hester, L	1
Dang, D	1
Barker, CJ	1
Heath, M	1
Mesiya, S	1
Tienabeso, T	1
Watson, K	1
Fang, L	1
Yu, Q	1
Yin, F	1
Yu, J	1
Zhang, Y	2
Zhu, D	1
Qin, X	1
Boland, EM	1
Mostafavi, SA	1
Solhi, M	2
Mohammadi, MR	2
Allega, OR	2
Leng, X	2
Vaccarino, A	1
Skelly, M	2
Lanzini, M	1
Soares, CN	2
Kennedy, SH	4
Slyepchenko, A	1
Minuzzi, L	1
Eltayebani, MM	1
Sassi, RB	1
Ghaziuddin, N	1
Shamseddeen, W	1
Bertram, H	1
McInnis, M	1
Wilcox, HC	1
Mitchell, PB	1
Fullerton, JM	1
Roberts, GMP	1
Glowinski, AL	1
Kamali, M	1
Stapp, E	1
Hulvershorn, LA	1
Nurnberger, J	1
Armitage, R	1
Robillard, R	1
Naismith, SL	1
Rogers, NL	1
Scott, EM	1
Ip, TK	1
Hermens, DF	1
Hickie, IB	1
Wang, B	1
Chen, D	1
Smeraldi, E	1
Delmonte, D	1
Kirshenbaum, GS	1
Burgess, CR	1
Déry, N	1
Fahnestock, M	1
Peever, JH	1
Roder, JC	1
Romo-Nava, F	1
Alvarez-Icaza González, D	1
Fresán-Orellana, A	1
Saracco Alvarez, R	1
Becerra-Palars, C	1
Moreno, J	1
Ontiveros Uribe, MP	1
Berlanga, C	1
Heinze, G	1
Buijs, RM	1
Thorpe, M	1
Pannell, J	1
Nance, M	1
Gaspar, L	1
van de Werken, M	1
Johansson, AS	1
Moriggi, E	1
Owe-Larsson, B	1
Kocks, JW	1
Lundkvist, GB	1
Gordijn, MC	1
Brown, SA	1
Souza, LC	1
Wilhelm, EA	1
Bortolatto, CF	1
Nogueira, CW	1
Boeira, SP	1
Jesse, CR	1
Jagannath, A	1
Foster, RG	1
Soreca, I	1
Nováková, M	1
Praško, J	1
Látalová, K	1
Sládek, M	1
Sumová, A	1
Mostafavi, A	1
Hamedi, M	1
Keshavarzi, M	1
Lajnef, M	1
Bellivier, F	5
Jamain, S	2
Gard, S	1
Kahn, JP	2
Henry, C	2
Leboyer, M	3
Baandrup, L	3
Lindschou, J	1
Winkel, P	1
Gluud, C	1
Glenthoj, BY	1
Franchi, JA	1
Abreu, T	1
Bragança, M	1
Anderson, G	2
Jacob, A	1
Yeim, S	1
Boudebesse, C	2
Belliviera, F	1
Moreira, J	1
Glenthøj, BY	1
Jennum, PJ	1
Bumb, JM	1
Enning, F	1
Mueller, JK	1
van der List, T	1
Rohleder, C	1
Findeisen, P	1
Noelte, I	1
Schwarz, E	1
Leweke, FM	1
Fagerlund, B	1
Glenthoj, B	1
Melo, MCA	1
Abreu, RLC	1
Linhares Neto, VB	1
de Bruin, PFC	1
de Bruin, VMS	1
Bradley, AJ	1
Webb-Mitchell, R	1
Hazu, A	1
Slater, N	1
Middleton, B	1
Gallagher, P	1
McAllister-Williams, H	1
Anderson, KN	1
Potter, M	1
Moses, A	1
Wozniak, J	1
Nierenberg, AA	1
Lamont, EW	1
Coutu, DL	1
Cermakian, N	1
Boivin, DB	1
Sarrazin, S	1
Vederine, FE	1
d'Albis, MA	1
Hamdani, N	1
Daban, C	1
Delavest, M	1
Lépine, JP	1
Mangin, JF	1
Poupon, C	1
Houenou, J	1
Milhiet, V	1
Kim, DR	1
Czarkowski, KA	1
Epperson, CN	1
Livianos, L	1
Sierra, P	1
Arques, S	1
García, A	1
Rojo, L	1
Dumaine, A	1
Pagan, C	1
Francelle, L	1
Goubran-Botros, H	1
Moreno, S	1
Deshommes, J	1
Moustafa, K	1
Le Dudal, K	1
Mathieu, F	1
Launay, JM	1
Mühleisen, TW	1
Cichon, S	1
Bourgeron, T	1
Wu, YH	1
Ursinus, J	1
Zhou, JN	1
Scheer, FA	1
Ai-Min, B	1
Jockers, R	1
van Heerikhuize, J	1
Swaab, DF	1
Postolache, TT	1
Oren, DA	1
Hallam, KT	2
Olver, JS	2
Norman, TR	4
Eli, R	1
Fasciano, J	1
Johnsson, A	1
Moan, J	1
Chambers, V	1
Begg, DP	1
McGrath, C	1
Srinivasan, V	1
Smits, M	1
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Lowe, AD	1
Kayumov, L	1
Pandi-Perumal, SR	1
Parry, B	1
Cardinali, DP	1
Phelps, J	1
Lewy, AJ	5
Wehr, TA	6
Goodwin, FK	2
Newsome, DA	3
Rosenthal, NE	4
Joffe, RT	1
Brown, P	1
Maurizi, CP	3
Wetterberg, L	6
Beck-Friis, J	3
Kjellman, BF	4
Ljunggren, JG	3
von Rosen, D	1
Claustrat, B	2
Chazot, G	2
Brun, J	2
Jordan, D	1
Sassolas, G	1
Winfree, AT	1
Branchey, L	1
Weinberg, U	1
Branchey, M	1
Linkowski, P	1
Mendlewicz, J	1
Kern, HA	1
Nurnberger, JI	4
Siever, LJ	1
Uhde, TW	1
Becker, LE	2
Markey, SP	1
Kopin, IJ	1
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Murphy, DG	2
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Abbas, M	2
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Leibenluft, E	2
Feldman-Naim, S	2
Turner, EH	2
Schwartz, PJ	1
Robertson, JM	1
Tanguay, PE	1
Thalén, BE	1
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Avery, D	1
Lenz, M	1
Landis, C	1
Wahlund, B	2
Grahn, H	2
Sääf, J	2
Nathan, PJ	1
Burrows, GD	2
Bersani, G	1
Garavini, A	1
Adkins, S	1
Lahiri, DK	1
Mayeda, A	1
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Miller, MJ	1
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Sandyk, R	4
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Randomized Placebo-Controlled Trial of Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder[NCT00502320]	Phase 4	50 participants (Actual)	Interventional	2006-09-30	Completed
Virtual Darkness as Additive Treatment in Mania- a Randomized Controlled Trial[NCT01818622]		69 participants (Actual)	Interventional	2012-02-29	Completed
Optimizing Light Wavelength for Treatment of Seasonal Affective Disorder[NCT00269633]	Phase 2	9 participants (Actual)	Interventional	2006-11-30	Completed
Characterization of Endogenous Melatonin Profiles in Children With Autism Spectrum Disorder.[NCT00691080]		58 participants (Actual)	Observational	2007-09-30	Completed
Usefulness of Bright Light Therapy in the Prevention of Delirium in Patients Undergoing Hematopoietic Stem Cell Transplant (HSCT)[NCT01700816]		40 participants (Actual)	Interventional	2012-10-31	Terminated (stopped due to Low incidence of delirium.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Clinician-rated measure of mood; evaluates classical 21 Hamilton Depression items, and 8-item subscale measuring atypical depression symptoms which commonly occur during SAD episodes. Score ranges from 0-89, higher scores indicate higher levels of depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

Depressive Symptoms at Baseline and Measured Monthly, as Measured by the Zung Depression Scale (ZDS)

Intervention	scores on a scale (Mean)
	Baseline	Month 1	Month 2	Month 3	Month 4
Placebo	19.99	15.97	19.47	20.65	23.68
Ramelteon	22.68	16.16	14.81	11.69	9.15

Self-rated scale to measure severity of depressive symptoms. Score ranges from 25-100, higher scores reflect more depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

Sleep Satisfaction at Baseline and Measured Monthly, as Measured by the Pittsburgh Sleep Quality Index (PSQI)

Intervention	scores on a scale (Mean)
	Baseline	Month 1	Month 2	Month 3	Month 4
Placebo	58.63	56.40	58.59	58.62	61.65
Ramelteon	63.06	54.35	53.51	49.26	46.14

Self-rated scale to measure quality of sleep via questions regarding sleep latency, duration, efficiency, disturbances, use of sleep medication, and daytime dysfunction. Score ranges from 0-21, higher scores represent more significant sleep disturbance. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

Structured Interview Guide for the Hamilton Depression Scale - Seasonal Affective Disorder Version (SIGH-SAD); Weekly for Three Weeks

Intervention	scores on a scale (Mean)
	Baseline	Month 1	Month 2	Month 3	Month 4
Placebo	11.45	8.67	8.62	9.88	9.61
Ramelteon	11.56	9.52	7.57	8.07	7.05

Outcome for Structured Interview Guide for the Hamilton Depression Scale - Seasonal Affective Disorder Version (SIGH-SAD) reported is the average over 3 weeks. Lower values represent less depressive symptoms. Range is 0-53. (NCT00269633)
Timeframe: Averaged over Three Weeks During Treatment

Hematocrit (HCT)

Intervention	units on a scale (Mean)
Red Light Box 657 nm	16.3
Blue Light Box 467 nm	8

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Hemoglobin (HGB)

Intervention	volume percentage (vol%) of red blood ce (Median)
Bright Light Therapy	28.20
Sham Light	26.70

Hospital Length of Stay

Intervention	g/dl (Median)
Bright Light Therapy	9.70
Sham Light	9.55

(NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Number of Participants Who Developed Delirium Based on Meeting Criteria on the Delirium Rating Scale and/or Memorial Delirium Assessment Scale

Intervention	days (Median)
Bright Light Therapy	18
Sham Light	18.5

Monday, Wednesday, and Friday assessments will begin after beginning light therapy and include the Delirium Rating Scale-Revised-98 (DRS-98)and Memorial Delirium Assessment Scale (MDAS) (NCT01700816)
Timeframe: From hospital admission until the date of first documented delirium, assessed up to 28 days post-transplant

Platelet Count

Intervention	Participants (Count of Participants)
Bright Light Therapy	1
Sham Light	0

Red Blood Cells (RBC)

Intervention	thousand cells/uL (Median)
Bright Light Therapy	39
Sham Light	33.5

Severity of Delirium Episodes: Memorial Delirium Assessment Scale (MDAS)

Intervention	M/uL (Median)
Bright Light Therapy	3.21
Sham Light	2.93

"Monday, Wednesday, and Friday assessments of the Memorial Delirium Assessment Scale (MDAS); Patients will receive assessments after beginning light therapy until day 28 post-transplant or discharge, whichever comes first.~10 item scale Items are rated on a four-point scale from 0 (none) to 3 (severe) depending on the level of impairment, rendering a maximum possible score of 30.~A score of 13 has been recommended as a cut-off for establishing the diagnosis of delirium" (NCT01700816)
Timeframe: From first documented episode of delirium until discharge from the hospital, assessed up to 28 days post-transplant

White Blood Cells (WBC)

Intervention	units on a scale (Number)
Bright Light Therapy	18

Serum Creatinine and Blood Urea Nitrogen (BUN)

Intervention	K/uL (Median)
Bright Light Therapy	2.30
Sham Light	4.75

Sodium (Na), Potassium (K), Chloride (Cl), and Carbon Dioxide (CO2)

Intervention	mg/dl (Median)
	Serum Creatinine	Blood Urea Nitrogen (BUN)
Bright Light Therapy	0.66	9
Sham Light	0.75	8.5

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT (Hematopoietic Stem Cell Transplantation). (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Article	Year
Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic review and meta-analysis. Human psychopharmacology, 2022, Volume: 37, Issue:2 Topics: Antipsychotic Agents; Bipolar Disorder; Humans; Melatonin; Metabolic Syndrome; Randomized Controlled	2022
Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis. CNS drugs, 2022, Volume: 36, Issue:4 Topics: Bipolar Disorder; Humans; Hypnotics and Sedatives; Mania; Melatonin; Sleep; Sleep Wake Disorders	2022
[Chronotherapy of affective disorders: principles and clinical aspects]. Der Nervenarzt, 2022, Volume: 93, Issue:9 Topics: Bipolar Disorder; Chronotherapy; Humans; Melatonin; Mood Disorders; Sleep; Sleep Deprivation; Sleep	2022
Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness. Current psychiatry reports, 2022, Volume: 24, Issue:11 Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Circadian Rhythm; Humans; Melatonin	2022
Measuring circadian function in bipolar disorders: Empirical and conceptual review of physiological, actigraphic, and self-report approaches. Bipolar disorders, 2020, Volume: 22, Issue:7 Topics: Actigraphy; Bipolar Disorder; Circadian Rhythm; Humans; Melatonin; Reproducibility of Results; Self	2020
Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Chronobiology international, 2021, Volume: 38, Issue:10 Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder, Major; Eyeglasses; Female; Humans; Light; M	2021
Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders. Current psychiatry reports, 2017, Volume: 19, Issue:4 Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Psychopathology; Sle	2017
Evidence for seasonal mania: a review. Journal of psychiatric practice, 2013, Volume: 19, Issue:4 Topics: Antimanic Agents; Bipolar Disorder; Circadian Rhythm; Humans; Light; Lithium Compounds; Melatonin; S	2013
Agomelatine in depression. Expert opinion on drug safety, 2013, Volume: 12, Issue:6 Topics: Acetamides; Animals; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Humans; Me	2013
The relationship between bipolar disorder and biological rhythms. The Journal of clinical psychiatry, 2014, Volume: 75, Issue:4 Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Genetic Predisposition to Disease; Huma	2014
Circadian rhythms and sleep in bipolar disorder: implications for pathophysiology and treatment. Current opinion in psychiatry, 2014, Volume: 27, Issue:6 Topics: Bipolar Disorder; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Initiation and Maintenance Disor	2014
Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. Current pharmaceutical design, 2015, Volume: 21, Issue:23 Topics: Antipsychotic Agents; Benzofurans; Bipolar Disorder; Circadian Rhythm; Cyclopropanes; Humans; Inappr	2015
The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles. Journal of affective disorders, 2015, Oct-01, Volume: 185 Topics: Acetamides; Affect; Antimanic Agents; Bipolar Disorder; Circadian Rhythm; Humans; Hypnotics and Seda	2015
Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways. Current pharmaceutical design, 2016, Volume: 22, Issue:8 Topics: Animals; Bipolar Disorder; Humans; Kynurenine; Melatonin; Signal Transduction; Tryptophan	2016
[Circadian markers and genes in bipolar disorder]. L'Encephale, 2015, Volume: 41, Issue:4 Suppl 1 Topics: Biomarkers; Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Gene Expression Regulation;	2015
Chronotype and circadian rhythm in bipolar disorder: A systematic review. Sleep medicine reviews, 2017, Volume: 34 Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Depression; Humans; Hydrocortisone; Mel	2017
Alternative treatments in pediatric bipolar disorder. Child and adolescent psychiatric clinics of North America, 2009, Volume: 18, Issue:2 Topics: Acupuncture; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Child; Humans; Hypericum; Inos	2009
Melatonin, circadian rhythms, and the clock genes in bipolar disorder. Current psychiatry reports, 2009, Volume: 11, Issue:6 Topics: Bipolar Disorder; Circadian Rhythm; CLOCK Proteins; Humans; Melatonin; Sleep Wake Disorders	2009
Circadian rhythms and clock genes in psychotic disorders. The Israel journal of psychiatry and related sciences, 2010, Volume: 47, Issue:1 Topics: Animals; Bipolar Disorder; Circadian Rhythm; CLOCK Proteins; Glycogen Synthase Kinase 3; Humans; Lit	2010
Circadian biomarkers, circadian genes and bipolar disorders. Journal of physiology, Paris, 2011, Volume: 105, Issue:4-6 Topics: Biological Clocks; Biomarkers; Bipolar Disorder; Body Temperature; Circadian Rhythm; Humans; Melaton	2011
The relationship between bipolar disorder, seasonality, and premenstrual symptoms. Current psychiatry reports, 2011, Volume: 13, Issue:6 Topics: Bipolar Disorder; Depression, Postpartum; Female; Humans; Melatonin; Premenstrual Syndrome; Seasonal	2011
Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder. Human molecular genetics, 2012, Sep-15, Volume: 21, Issue:18 Topics: Acetylserotonin O-Methyltransferase; Bipolar Disorder; Case-Control Studies; Cells, Cultured; DNA Mu	2012
Circadian phase shifting, alerting, and antidepressant effects of bright light treatment. Clinics in sports medicine, 2005, Volume: 24, Issue:2 Topics: Adaptation, Physiological; Adult; Bipolar Disorder; Circadian Rhythm; Depression; Eye Diseases; Fema	2005
[Rhythms, depressions and light]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2006, Apr-06, Volume: 126, Issue:8 Topics: Animals; Biological Clocks; Bipolar Disorder; Brain; Circadian Rhythm; Humans; Jet Lag Syndrome; Lig	2006
Melatonin in mood disorders. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:3 Topics: Antidepressive Agents; Biomarkers; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Depressi	2006
Clinical and biological correlates of sleep deprivation in depression. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1984, Volume: 29, Issue:6 Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Homovanillic Acid; Humans; Hydrocortisone;	1984
A mechanism of mania and the chemistry of dreams: a hypothesis. Southern medical journal, 1984, Volume: 77, Issue:12 Topics: Biological Clocks; Bipolar Disorder; Dreams; Humans; Lithium; Locus Coeruleus; Melatonin; Norepineph	1984
Human body clocks and the timing of sleep. Nature, 1982, May-06, Volume: 297, Issue:5861 Topics: Aerospace Medicine; Biological Clocks; Bipolar Disorder; Humans; Light; Melatonin; Models, Biologica	1982
The circadian system and the therapeutics of the affective disorders. Pharmacology & therapeutics, 1995, Volume: 65, Issue:2 Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Behavior Therapy; Bipolar Disorder; Circadian	1995
Guidelines for prescribing melatonin. Annals of medicine, 1998, Volume: 30, Issue:1 Topics: Aged; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Drug Administration Schedule; Female;	1998
The relationship of pineal calcification and melatonin secretion to the pathophysiology of tardive dyskinesia and Tourette's syndrome. The International journal of neuroscience, 1991, Volume: 58, Issue:3-4 Topics: Adult; Aged; Bipolar Disorder; Calcinosis; Dyskinesia, Drug-Induced; Female; Humans; Male; Melatonin	1991
Tardive dyskinesia in bipolar disorders: possible role of pineal melatonin. The International journal of neuroscience, 1990, Volume: 52, Issue:3-4 Topics: Bipolar Disorder; Dyskinesia, Drug-Induced; Humans; Melatonin; Pineal Gland	1990
[Melatonin in seasonal affective disorder]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1990, Volume: 23, Issue:5 Topics: Animals; Bipolar Disorder; Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasons	1990
Melatonin: a new probe in psychiatric investigation? The British journal of psychiatry : the journal of mental science, 1989, Volume: 155 Topics: Animals; Bipolar Disorder; Circadian Rhythm; Humans; Light; Melatonin; Mental Disorders; Pineal Glan	1989
Affective disorders and circadian rhythms. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:3 Topics: Affect; Antidepressive Agents; Bipolar Disorder; Body Temperature; Circadian Rhythm; Cues; Depressiv	1986

Article	Year
Efficacy of melatonin as an adjunct in the treatment of acute mania: a double-blind and placebo-controlled trial. International clinical psychopharmacology, 2020, Volume: 35, Issue:2 Topics: Adolescent; Adult; Aged; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combination; Female; H	2020
Melatonin In Acute Mania Investigation (MIAMI-UK). A randomized controlled trial of add-on melatonin in bipolar disorder. Bipolar disorders, 2021, Volume: 23, Issue:2 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Double-Blind Method; Humans; Mania;	2021
Melatonin for Reducing Weight Gain Following Administration of Atypical Antipsychotic Olanzapine for Adolescents with Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of child and adolescent psychopharmacology, 2017, Volume: 27, Issue:5 Topics: Adolescent; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Body Weight;	2017
Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial. Bipolar disorders, 2014, Volume: 16, Issue:4 Topics: Adult; Analysis of Variance; Anthropometry; Antioxidants; Bipolar Disorder; Double-Blind Method; Fem	2014
Melatonin decreases olanzapine induced metabolic side-effects in adolescents with bipolar disorder: a randomized double-blind placebo-controlled trial. Acta medica Iranica, 2014, Volume: 52, Issue:10 Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Child; Double-Blind Method; Fem	2014
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia or bipolar disorder: A randomised, placebo-controlled, blinded trial. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2016, Volume: 17, Issue:7 Topics: Adult; Aged; Benzodiazepines; Bipolar Disorder; Denmark; Double-Blind Method; Female; Humans; Logist	2016
Objective and subjective sleep quality: Melatonin versus placebo add-on treatment in patients with schizophrenia or bipolar disorder withdrawing from long-term benzodiazepine use. Psychiatry research, 2016, 06-30, Volume: 240 Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Central Nervous System Depressants;	2016
Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo. European archives of psychiatry and clinical neuroscience, 2017, Volume: 267, Issue:2 Topics: Adult; Antioxidants; Benzodiazepines; Bipolar Disorder; Cognitive Dysfunction; Double-Blind Method;	2017
Is melatonin an adjunctive stabilizer? Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:1 Topics: Bipolar Disorder; Central Nervous System Depressants; Humans; Melatonin; Sleep Initiation and Mainte	2012
Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. The Journal of clinical psychiatry, 1997, Volume: 58, Issue:9 Topics: Affect; Bipolar Disorder; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Drug	1997
Melatonin add-on in manic patients with treatment resistant insomnia. Progress in neuro-psychopharmacology & biological psychiatry, 2000, Volume: 24, Issue:2 Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Bipolar Disorder; Drug Resistance; Fem	2000
Coadministration of melatonin and fluoxetine does not improve the 3-month outcome following ECT. The journal of ECT, 2001, Volume: 17, Issue:2 Topics: Aged; Bipolar Disorder; Combined Modality Therapy; Depressive Disorder, Major; Dose-Response Relatio	2001
The relationship of pineal calcification and melatonin secretion to the pathophysiology of tardive dyskinesia and Tourette's syndrome. The International journal of neuroscience, 1991, Volume: 58, Issue:3-4 Topics: Adult; Aged; Bipolar Disorder; Calcinosis; Dyskinesia, Drug-Induced; Female; Humans; Male; Melatonin	1991
Effect of lysine vasopressin in depressed patients on mood and 24-hour rhythm of growth hormone, cortisol, melatonin and prolactin. Psychoneuroendocrinology, 1985, Volume: 10, Issue:3 Topics: Adult; Aged; Bipolar Disorder; Circadian Rhythm; Clinical Trials as Topic; Depressive Disorder; Doub	1985

Article	Year
Impulsivity and sleep and circadian rhythm disturbance predict next-day mood symptoms in a sample at high risk for or with recent-onset bipolar spectrum disorder: An ecological momentary assessment study. Journal of affective disorders, 2022, 02-01, Volume: 298, Issue:Pt A Topics: Adult; Bipolar Disorder; Circadian Rhythm; Ecological Momentary Assessment; Female; Humans; Impulsiv	2022
Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study. Journal of affective disorders, 2022, 10-15, Volume: 315 Topics: Adolescent; Bipolar Disorder; Case-Control Studies; Chronobiology Disorders; Circadian Rhythm; Human	2022
Methylation of melatonin receptors in patients with unipolar and bipolar depression. Mechanisms of ageing and development, 2023, Volume: 211 Topics: Bipolar Disorder; Humans; Leukocytes, Mononuclear; Melatonin; Methylation; Receptors, Melatonin	2023
Effects of exogenous melatonin on sleep and circadian rhythm parameters in bipolar disorder with comorbid delayed sleep-wake phase disorder: An actigraphic study. Journal of psychiatric research, 2023, Volume: 165 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Comorbidity; Humans; Male; Melatonin; Middle Aged; Sleep	2023
Circadian, Reward, and Emotion Systems in Teens prospective longitudinal study: protocol overview of an integrative reward-circadian rhythm model of first onset of bipolar spectrum disorder in adolescence. BMC psychiatry, 2023, 08-17, Volume: 23, Issue:1 Topics: Adolescent; Bipolar Disorder; Circadian Rhythm; Emotions; Humans; Longitudinal Studies; Melatonin; P	2023
Melatonin secretion patterns are associated with cognitive vulnerability and brain structure in bipolar depression. Chronobiology international, 2023, 09-02, Volume: 40, Issue:9 Topics: Bipolar Disorder; Brain; Circadian Rhythm; Cognition; Humans; Melatonin; Sleep	2023
Melatonin MT Pharmacological research, 2023, Volume: 198 Topics: Animals; Bipolar Disorder; Humans; Melatonin; Mice; Psychopharmacology; Receptor, Melatonin, MT1; Re	2023
Melatonin suppression by melanopsin-weighted light in patients with bipolar I disorder compared to healthy controls Journal of psychiatry & neuroscience : JPN, 2020, 03-01, Volume: 45, Issue:2 Topics: Adult; Bipolar Disorder; Case-Control Studies; Endophenotypes; Female; Humans; Light; Male; Melatoni	2020
Sex and race influence objective and self-report sleep and circadian measures in emerging adults independently of risk for bipolar spectrum disorder. Scientific reports, 2020, 08-13, Volume: 10, Issue:1 Topics: Actigraphy; Adolescent; Adult; Bipolar Disorder; Circadian Rhythm; Female; Humans; Male; Melatonin;	2020
Melatonin Receptor Gene Polymorphism in Bipolar-I Disorder. Archives of medical research, 2021, Volume: 52, Issue:5 Topics: Bipolar Disorder; Gene Frequency; Genotype; Humans; Melatonin; Polymorphism, Single Nucleotide; Rece	2021
Melatonin receptor agonists for bipolar mania: A systematic review and meta-analyses of double-blind randomized placebo-controlled trials. Bipolar disorders, 2021, Volume: 23, Issue:3 Topics: Antipsychotic Agents; Bipolar Disorder; Double-Blind Method; Humans; Mania; Melatonin; Receptors, Me	2021
Combined cortisol and melatonin measurements with detailed parameter analysis can assess the circadian rhythms in bipolar disorder patients. Brain and behavior, 2021, Volume: 11, Issue:7 Topics: Bipolar Disorder; Circadian Rhythm; Humans; Hydrocortisone; Melatonin; Saliva	2021
Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis. Journal of affective disorders, 2018, 01-01, Volume: 225 Topics: Actigraphy; Adult; Bipolar Disorder; Case-Control Studies; Circadian Rhythm; Depressive Disorder, Ma	2018
Association of functioning and quality of life with objective and subjective measures of sleep and biological rhythms in major depressive and bipolar disorder. The Australian and New Zealand journal of psychiatry, 2019, Volume: 53, Issue:7 Topics: Actigraphy; Adolescent; Adult; Aged; Bipolar Disorder; Circadian Rhythm; Depressive Disorder, Major;	2019
Salivary melatonin onset in youth at familial risk for bipolar disorder. Psychiatry research, 2019, Volume: 274 Topics: Adolescent; Adult; Biomarkers; Bipolar Disorder; Child; Circadian Rhythm; Female; Genetic Predisposi	2019
Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. European psychiatry : the journal of the Association of European Psychiatrists, 2013, Volume: 28, Issue:7 Topics: Adolescent; Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Me	2013
Attenuation of mania-like behavior in Na(+),K(+)-ATPase α3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise. Neuroscience, 2014, Feb-28, Volume: 260 Topics: Animals; Behavior, Animal; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Disease Models, Anim	2014
Agomelatine-associated manic switch in bipolar depression: a case report. The Australian and New Zealand journal of psychiatry, 2014, Volume: 48, Issue:10 Topics: Acetamides; Adult; Antidepressive Agents; Bipolar Disorder; Female; Humans; Melatonin	2014
Human cellular differences in cAMP--CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder. The European journal of neuroscience, 2014, Volume: 40, Issue:1 Topics: Adult; Bipolar Disorder; Cells, Cultured; Cohort Studies; Cyclic AMP; Cyclic AMP Response Element-Bi	2014
The protective effect of melatonin against brain oxidative stress and hyperlocomotion in a rat model of mania induced by ouabain. Behavioural brain research, 2014, Sep-01, Volume: 271 Topics: Animals; Antimanic Agents; Bipolar Disorder; Catalase; Cerebral Cortex; Disease Models, Animal; Glut	2014
CREB signalling in bipolar disease (commentary on Gaspar et al.): commentary on Gaspar et al. 2014. The European journal of neuroscience, 2014, Volume: 40, Issue:1 Topics: Bipolar Disorder; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Female; Humans; Light; Ma	2014
The circadian system of patients with bipolar disorder differs in episodes of mania and depression. Bipolar disorders, 2015, Volume: 17, Issue:3 Topics: Adult; Bipolar Disorder; Case-Control Studies; Chronobiology Disorders; Circadian Clocks; Circadian	2015
Genetic association study of circadian genes with seasonal pattern in bipolar disorders. Scientific reports, 2015, May-19, Volume: 5 Topics: Adult; Basic Helix-Loop-Helix Transcription Factors; Bipolar Disorder; Circadian Clocks; Circadian R	2015
Lithium and bipolar disorder: Impacts from molecular to behavioural circadian rhythms. Chronobiology international, 2016, Volume: 33, Issue:4 Topics: ARNTL Transcription Factors; Behavior; Bipolar Disorder; Body Temperature; Circadian Rhythm; Humans;	2016
Differential melatonin alterations in cerebrospinal fluid and serum of patients with major depressive disorder and bipolar disorder. Comprehensive psychiatry, 2016, Volume: 68 Topics: Adult; Bipolar Disorder; Case-Control Studies; Circadian Rhythm; Depressive Disorder, Major; Enzyme-	2016
Sleep and circadian rhythm disturbance in bipolar disorder. Psychological medicine, 2017, Volume: 47, Issue:9 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Comorbidity; Female; Humans; Male; Melatonin; Middle Aged	2017
Low-dose buspirone, melatonin and low-dose bupropion added to mood stabilizers for severe treatment-resistant bipolar depression. Psychotherapy and psychosomatics, 2009, Volume: 78, Issue:6 Topics: Adult; Antidepressive Agents; Bipolar Disorder; Bupropion; Buspirone; Drug Therapy, Combination; Fem	2009
The role of melatonin in post-partum psychosis and depression associated with bipolar disorder. Journal of perinatal medicine, 2010, Volume: 38, Issue:6 Topics: Animals; Bipolar Disorder; Depression, Postpartum; Female; Humans; Melatonin; Models, Animal; Pregna	2010
MRI exploration of pineal volume in bipolar disorder. Journal of affective disorders, 2011, Volume: 135, Issue:1-3 Topics: Adolescent; Adult; Aged; Bipolar Disorder; Case-Control Studies; Circadian Rhythm; Female; Humans; M	2011
Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. Journal of affective disorders, 2013, Volume: 148, Issue:2-3 Topics: Aged; Aged, 80 and over; Bipolar Disorder; Case-Control Studies; Circadian Rhythm; Depressive Disord	2013
Melatonin sensitivity to light in monozygotic twins discordant for bipolar I disorder. The Australian and New Zealand journal of psychiatry, 2005, Volume: 39, Issue:10 Topics: Adult; Biomarkers; Bipolar Disorder; Female; Genetic Predisposition to Disease; Humans; Melatonin; P	2005
A chronopharmacological diagnostic test and treatment for bipolar disorder and depression: nitric oxide release during sleep causes it to become depressogenic in a subset of patients. Medical hypotheses, 2006, Volume: 66, Issue:1 Topics: Age Factors; Bipolar Disorder; Brain; Humans; Melatonin; Moclobemide; Nitric Oxide; Polymorphism, Ge	2006
The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins. Psychoneuroendocrinology, 2006, Volume: 31, Issue:7 Topics: Adolescent; Adult; Area Under Curve; Bipolar Disorder; Circadian Rhythm; Darkness; Down-Regulation;	2006
Dark therapy for bipolar disorder using amber lenses for blue light blockade. Medical hypotheses, 2008, Volume: 70, Issue:2 Topics: Bipolar Disorder; Circadian Rhythm; Darkness; Eyeglasses; Humans; Melatonin; Models, Biological; Pho	2008
Manic-depressive patients may be supersensitive to light. Lancet (London, England), 1981, Feb-14, Volume: 1, Issue:8216 Topics: Bipolar Disorder; Circadian Rhythm; Humans; Light; Melatonin	1981
Circadian rhythms in melatonin and cortisol secretion in depression. Advances in biochemical psychopharmacology, 1984, Volume: 39 Topics: Bipolar Disorder; Circadian Rhythm; Cushing Syndrome; Depressive Disorder; Dexamethasone; Humans; Hy	1984
Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinology, 1984, Volume: 9, Issue:3 Topics: Adult; Age Factors; Bipolar Disorder; Body Height; Body Weight; Contraceptives, Oral; Depressive Dis	1984
A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression. Biological psychiatry, 1984, Volume: 19, Issue:8 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Hypo	1984
Effects of light on human melatonin production and the human circadian system. Progress in neuro-psychopharmacology & biological psychiatry, 1983, Volume: 7, Issue:4-6 Topics: Animals; Bipolar Disorder; Blindness; Circadian Rhythm; Humans; Light; Melatonin; Rats; Seasons	1983
Twenty-four-hour serum levels of TSH in affective disorders. Acta psychiatrica Scandinavica, 1984, Volume: 69, Issue:6 Topics: Acute Disease; Adult; Bipolar Disorder; Depressive Disorder; Dexamethasone; Female; Humans; Lithium;	1984
Simultaneous study of 24-hour patterns of melatonin and cortisol secretion in depressed patients. Neuropsychobiology, 1982, Volume: 8, Issue:5 Topics: Adult; Amitriptyline; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydro	1982
Bright artificial light treatment of a manic-depressive patient with a seasonal mood cycle. The American journal of psychiatry, 1982, Volume: 139, Issue:11 Topics: Bipolar Disorder; Humans; Lighting; Male; Melatonin; Middle Aged; Phototherapy; Seasons	1982
Melatonin secretion as a neurobiological "marker" and effects of light in humans. Psychopharmacology bulletin, 1982, Volume: 18, Issue:4 Topics: Bipolar Disorder; Circadian Rhythm; Humans; Light; Melatonin	1982
Geomagnetic storms: association with incidence of depression as measured by hospital admission. The British journal of psychiatry : the journal of mental science, 1994, Volume: 164, Issue:3 Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Geological Phenomena; Geology; Hosp	1994
Seasonal affective disorder: response to light as measured by electroencephalogram, melatonin suppression, and cerebral blood flow. The British journal of psychiatry : the journal of mental science, 1993, Volume: 163 Topics: Bipolar Disorder; Brain; Cerebral Cortex; Circadian Rhythm; Contrast Sensitivity; Depressive Disorde	1993
Melatonin rhythms in seasonal affective disorder. The British journal of psychiatry : the journal of mental science, 1993, Volume: 163 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Individuality; Male;	1993
[Melatonin excretion in patients with depression under the action of light of increased intensity]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1995, Volume: 95, Issue:4 Topics: Adolescent; Adult; Bipolar Disorder; Chronic Disease; Depressive Disorder, Major; Female; Fluorometr	1995
Nocturnal melatonin and 24-hour 6-sulphatoxymelatonin levels in various phases of bipolar affective disorder. Psychiatry research, 1996, Jul-31, Volume: 63, Issue:2-3 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Mid	1996
Salivary and plasma measures of dim light melatonin onset (DLMO) in patients with rapid cycling bipolar disorder. Biological psychiatry, 1996, Oct-15, Volume: 40, Issue:8 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Middle Aged; Refe	1996
Case study: the use of melatonin in a boy with refractory bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:6 Topics: Bipolar Disorder; Child; Humans; Male; Melatonin; Sleep Initiation and Maintenance Disorders; Sleep	1997
Cortisol in light treatment of seasonal and non-seasonal depression: relationship between melatonin and cortisol. Acta psychiatrica Scandinavica, 1997, Volume: 96, Issue:5 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Male	1997
Affective disorder subtyped by psychomotor symptoms, monoamine oxidase, melatonin and cortisol: identification of patients with latent bipolar disorder. European archives of psychiatry and clinical neuroscience, 1998, Volume: 248, Issue:5 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Hydrocortisone; Male; Melatonin; Middl	1998
Diagnostic subgrouping of depressed patients by principal component analysis and visualized pattern recognition. Psychiatry research, 1998, Dec-14, Volume: 81, Issue:3 Topics: Adult; Biomarkers; Bipolar Disorder; Blood Platelets; Depressive Disorder; Dexamethasone; Female; Fo	1998
Melatonin sensitivity to dim white light in affective disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:3 Topics: Adolescent; Adult; Aged; Biomarkers; Bipolar Disorder; Depressive Disorder, Major; Humans; Light; Me	1999
A preliminary understanding of mania: roles for melatonin, vasotocin and rapid-eye-movement sleep. Medical hypotheses, 2000, Volume: 54, Issue:1 Topics: Bipolar Disorder; Humans; Melatonin; Sleep, REM; Vasotocin	2000
Melatonin suppression by light in euthymic bipolar and unipolar patients. Archives of general psychiatry, 2000, Volume: 57, Issue:6 Topics: Adrenocorticotropic Hormone; Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female;	2000
[Neurobiological findings in a patient with 48-hour rapid cycling bipolar affective disorder. A case report]. Der Nervenarzt, 2001, Volume: 72, Issue:7 Topics: Bipolar Disorder; Cerebral Cortex; Circadian Rhythm; Hormones; Human Growth Hormone; Humans; Hydroco	2001
Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. Archives of general psychiatry, 1992, Volume: 49, Issue:7 Topics: Adult; Aged; Bipolar Disorder; Circadian Rhythm; Cross-Sectional Studies; Depressive Disorder; Dexam	1992
Melatonin response to bright light in recovered, drug-free, bipolar patients. Psychiatry research, 1991, Volume: 38, Issue:1 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Female; Follow-Up Studies; Humans; Light; Male; Melatonin	1991
Circadian rhythm of melatonin secretion and body temperature in a patient with seasonal affective disorder. The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:1 Topics: Aged; Bipolar Disorder; Body Temperature Regulation; Circadian Rhythm; Female; Humans; Melatonin; Ps	1991
Coexisting bipolar affective disorder and multiple sclerosis: the role of the pineal gland. The International journal of neuroscience, 1991, Volume: 59, Issue:4 Topics: Autoimmune Diseases; Bipolar Disorder; Circadian Rhythm; Depression; Humans; Immune Tolerance; Light	1991
Tardive dyskinesia associated with depression in a bipolar patient: possible role of melatonin. The International journal of neuroscience, 1990, Volume: 52, Issue:1-2 Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Depression; Dyskinesia, Drug-Induced; Humans; Male; M	1990
Melatonin suppression in bipolar and unipolar mood disorders. Psychiatry research, 1990, Volume: 33, Issue:2 Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Humans; Light; Melatonin; Psychiatric Statu	1990
The therapeutic potential for tryptophan and melatonin: possible roles in depression, sleep, Alzheimer's disease and abnormal aging. Medical hypotheses, 1990, Volume: 31, Issue:3 Topics: Aging; Animals; Bipolar Disorder; Dementia; Depressive Disorder; Humans; Melatonin; Mental Disorders	1990
Melatonin and cortisol "switches" during mania, depression, and euthymia in a drug-free bipolar patient. The Journal of nervous and mental disease, 1989, Volume: 177, Issue:5 Topics: Adult; Bipolar Disorder; Blood Specimen Collection; Circadian Rhythm; Depressive Disorder; Evaluatio	1989
Human melatonin suppression by light is intensity dependent. Journal of pineal research, 1989, Volume: 6, Issue:2 Topics: Adult; Bipolar Disorder; Dose-Response Relationship, Radiation; Female; Humans; Light; Lighting; Mal	1989
Depression and photophobic behavior. The American journal of psychiatry, 1988, Volume: 145, Issue:11 Topics: Bipolar Disorder; Female; Humans; Light; Melatonin; Middle Aged; Seasons	1988
Supersensitivity to melatonin suppression by light in young people at high risk for affective disorder. A preliminary report. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1988, Volume: 1, Issue:3 Topics: Adolescent; Adult; Biomarkers; Bipolar Disorder; Female; Humans; Light; Male; Melatonin; Mood Disord	1988
Supersensitivity to light: possible trait marker for manic-depressive illness. The American journal of psychiatry, 1985, Volume: 142, Issue:6 Topics: Adult; Bipolar Disorder; Circadian Rhythm; Female; Humans; Hypothalamus; Light; Male; Melatonin; Mid	1985
Rapid antidepressant activity of destyr gamma endorphin: correlation with urinary melatonin. Biological psychiatry, 1985, Volume: 20, Issue:9 Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Endorphins; Female; Humans; Male; Melatonin; Mid	1985

melatonin and Affective Psychosis, Bipolar