melatonin has been researched along with Affective Disorders in 89 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a comprehensive systematic review of randomized clinical trials on patients with mood disorders, comparing melatonin to placebo." | 8.95 | Melatonin as a treatment for mood disorders: a systematic review. ( Cordey, JH; Cowen, PJ; De Crescenzo, F; Gibson, JC; Lennox, A; Quested, DJ; Stockton, S, 2017) |
| " In this review, we summarize the different hypotheses on pathophysiology mechanisms underlying depressive disorders and put a special emphasis on the alterations of melatonin secretion and associated changes in biological rhythms that characterize mood disorders." | 8.89 | Biological rhythms and melatonin in mood disorders and their treatments. ( Hamon, M; Lanfumey, L; Mongeau, R, 2013) |
| "Melatonin's involvement in various mood disorders is reviewed based on studies undertaken in patients with MDD, BPD and SAD." | 8.88 | Role of melatonin in mood disorders and the antidepressant effects of agomelatine. ( Brzezinski, A; De Berardis, D; Shillcutt, SD; Srinivasan, V, 2012) |
| "Melatonin improved mood, anxiety levels, and quality of life while decreasing cortisol levels in patients with fibromyalgia." | 7.91 | Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. ( Castaño, MY; Garrido, M; Gómez, MÁ; Rodríguez, AB, 2019) |
| "Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin." | 7.85 | Pineal volume and evening melatonin in young people with affective disorders. ( Abelmann, AC; Bennett, MR; Carpenter, JS; Hatton, SN; Hermens, DF; Hickie, IB; Lagopoulos, J; Robillard, R, 2017) |
| "Melatonin is an indole analog hormone, which is generally produced by the pineal gland." | 6.53 | The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment. ( Demirci, K; Espino, J; Uguz, AC, 2016) |
| ", light therapy, sleep deprivation, sleep phase advance and dark therapy, pharmacological in the form of melatonin and psychological consisting of interpersonal and social rhythm therapy or cognitive behavioral therapy for insomnia modified for patients with bipolar disorder." | 5.22 | [Chronotherapy of affective disorders: principles and clinical aspects]. ( Ludwig, VM; Münch, I; Ritter, P; Wirz-Justice, A, 2022) |
| "We conducted a comprehensive systematic review of randomized clinical trials on patients with mood disorders, comparing melatonin to placebo." | 4.95 | Melatonin as a treatment for mood disorders: a systematic review. ( Cordey, JH; Cowen, PJ; De Crescenzo, F; Gibson, JC; Lennox, A; Quested, DJ; Stockton, S, 2017) |
| " In this review, we summarize the different hypotheses on pathophysiology mechanisms underlying depressive disorders and put a special emphasis on the alterations of melatonin secretion and associated changes in biological rhythms that characterize mood disorders." | 4.89 | Biological rhythms and melatonin in mood disorders and their treatments. ( Hamon, M; Lanfumey, L; Mongeau, R, 2013) |
| "Melatonin's involvement in various mood disorders is reviewed based on studies undertaken in patients with MDD, BPD and SAD." | 4.88 | Role of melatonin in mood disorders and the antidepressant effects of agomelatine. ( Brzezinski, A; De Berardis, D; Shillcutt, SD; Srinivasan, V, 2012) |
| " We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol and melatonin), and we assess the implications for CT and adjustment to shiftwork and jet lag." | 4.88 | Circadian typology: a comprehensive review. ( Adan, A; Archer, SN; Di Milia, L; Hidalgo, MP; Natale, V; Randler, C, 2012) |
| "Recent refinements in methodology allow chronobiological researchers to answer the following questions: is there circadian misalignment in sleep and mood disturbances, and, if so, is it of the phase-advance or phase-delay type? Measurement of the dim light melatonin onset-to-midsleep interval, or phase-angle difference, in sleep and mood disorders should answer these questions." | 4.85 | Circadian misalignment in mood disturbances. ( Lewy, AJ, 2009) |
| "Melatonin improved mood, anxiety levels, and quality of life while decreasing cortisol levels in patients with fibromyalgia." | 3.91 | Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. ( Castaño, MY; Garrido, M; Gómez, MÁ; Rodríguez, AB, 2019) |
| "Melatonin and melatonin agonists offer novel treatments for sleep and mood disorders, particularly where circadian misalignment is also present." | 3.91 | Advances of Melatonin-Based Therapies in the Treatment of Disturbed Sleep and Mood. ( Alston, M; Cain, SW; Rajaratnam, SMW, 2019) |
| "Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin." | 3.85 | Pineal volume and evening melatonin in young people with affective disorders. ( Abelmann, AC; Bennett, MR; Carpenter, JS; Hatton, SN; Hermens, DF; Hickie, IB; Lagopoulos, J; Robillard, R, 2017) |
| "To study disturbances of sleep and circadian rhythms in patients with cardiovascular diseases taking into account the level of melatonin secretion and to optimize a complex approach to their treatment." | 3.81 | [Sleep disorders and circadian rhythms in diseases of the cardiovascular system]. ( Eneeva, MA; Kamchatnov, PR; Kostenko, EV; Petrova, LV, 2015) |
| "To study melatonin secretion and its correlations with poststroke cognitive, emotional impairment and sleep quality in the acute period of stroke and to assess treatment efficacy of melaxen." | 3.80 | [Poststroke cognitive, emotional impairment and sleep quality: efficience of treatment with melaxen]. ( Kulesh, AA; Shestakov, VV, 2014) |
| "Melatonin (MLT) and serotonin (5-HT) are two biosynthetically related compounds implicated in several common physiological functions and the etiology of mood disorders." | 3.78 | Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle. ( Bambico, FR; Domínguez-López, S; Gobbi, G; Labonté, B; Leyton, M; Mahar, I; Ochoa-Sánchez, R, 2012) |
| "To assess urinary 6-sulphatoxymelatonin levels in a large consecutive series of patients with migraine and several comorbidities (chronic fatigue, fibromyalgia, insomnia, anxiety, and depression) as compared with controls." | 3.76 | Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. ( Cipolla-Neto, J; de Souza Vieira, DS; Lin, J; Masruha, MR; Minett, TS; Peres, MF; Vilanova, LC; Zukerman, E, 2010) |
| "We studied mood disorders and urinary melatonin excretion in 382 postmenopausal women." | 3.71 | Depression and endogenous melatonin in postmenopausal women. ( Assmus, JD; Elliott, JA; Klauber, MR; Kripke, DF; Langer, RD; Rex, KM; Tuunainen, A, 2002) |
| "No mood disorders were detectable at baseline (HLM 8." | 2.73 | Effects of the heart-lung machine on melatonin metabolism and mood disturbances. ( Chenevard, R; Erne, P; Suter, Y, 2008) |
| "a persistent condition of past insomnia and aging per se) increase the risk of insomnia during menopause." | 2.66 | Insomnia and menopause: a narrative review on mechanisms and treatments. ( Agostoni, EC; Campana, C; Marra, S; Nappi, RE; Nobili, L; Palagini, L; Proserpio, P, 2020) |
| "Melatonin is an indole analog hormone, which is generally produced by the pineal gland." | 2.53 | The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment. ( Demirci, K; Espino, J; Uguz, AC, 2016) |
| "sleep and mood), immune function, cancer initiation and growth, as well as the correlation between melatonin levels and cancer risk, are hereinafter recorded and summarized." | 2.49 | Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks. ( Antoniello, N; Faliva, MA; Perna, S; Rondanelli, M, 2013) |
| "Pharmacological treatment of insomnia include the use of benzodiazepine and non-benzodiazepine drugs like zolpidem, zaleplon, Zopiclone." | 2.48 | Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders. ( Brown, GM; Brzezinski, A; Othaman, Z; Prasad, A; Srinivasan, V; Zakaria, R, 2012) |
| "Bright light therapy is used to treat seasonal affective disorders." | 2.46 | Circadian rhythms and depression. ( Barriball, E; Boyce, P, 2010) |
| " Different dosage regimens are effective: photoperiod extension (3, 2, or 1 hr WL at dawn and dusk); morning only (2, 1, or 1/2 hr); midday only (4 or 2 hr); and evening only (5 or 2 hr)." | 2.37 | Light therapy for depression: present status, problems, and perspectives. ( Wirz-Justice, A, 1986) |
| "Seven PMDD women who indicated insomnia during LP, and five controls, spent every third night throughout a complete menstrual cycle sleeping in the laboratory." | 1.38 | Nocturnal polysomnographic sleep across the menstrual cycle in premenstrual dysphoric disorder. ( Boivin, DB; Lespérance, P; Ng Ying Kin, NM; Shechter, A, 2012) |
| "Seasonal affective disorders have recently been individualized by American authors." | 1.28 | [Seasonal affective disorders, a new clinical category]. ( Attar-Levy, D; Lemperière, T; Lesur, A, 1990) |
| "Melatonin is a major endocrine product of the pineal gland." | 1.28 | Plasma melatonin levels in affective states. ( Burrows, GD; Judd, FK; Marriott, PM; McIntyre, IM; Norman, TR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (23.60) | 18.7374 |
| 1990's | 19 (21.35) | 18.2507 |
| 2000's | 17 (19.10) | 29.6817 |
| 2010's | 27 (30.34) | 24.3611 |
| 2020's | 5 (5.62) | 2.80 |
| Authors | Studies |
|---|---|
| Faltraco, F | 1 |
| Palm, D | 1 |
| Coogan, A | 1 |
| Simon, F | 1 |
| Tucha, O | 1 |
| Thome, J | 1 |
| Scott, MR | 1 |
| McClung, CA | 1 |
| Borisova, AB | 1 |
| Veltishchev, DY | 1 |
| Lisitsyna, TA | 1 |
| Reshetnyak, TM | 1 |
| Seravina, OF | 1 |
| Kovalevskaya, OB | 1 |
| Cheldieva, FA | 1 |
| Abramkin, AA | 1 |
| Bokhan, NA | 1 |
| Roshchina, OV | 1 |
| Simutkin, GG | 1 |
| Levchuk, LA | 1 |
| Ivanova, SA | 1 |
| Ludwig, VM | 1 |
| Münch, I | 1 |
| Wirz-Justice, A | 3 |
| Ritter, P | 1 |
| Mendoza, J | 1 |
| Proserpio, P | 1 |
| Marra, S | 1 |
| Campana, C | 1 |
| Agostoni, EC | 1 |
| Palagini, L | 2 |
| Nobili, L | 1 |
| Nappi, RE | 1 |
| De Crescenzo, F | 1 |
| Lennox, A | 1 |
| Gibson, JC | 1 |
| Cordey, JH | 1 |
| Stockton, S | 1 |
| Cowen, PJ | 1 |
| Quested, DJ | 1 |
| Carpenter, JS | 2 |
| Robillard, R | 2 |
| Hermens, DF | 2 |
| Naismith, SL | 1 |
| Gordon, C | 2 |
| Scott, EM | 1 |
| Hickie, IB | 2 |
| Söderquist, F | 1 |
| Sundberg, I | 1 |
| Ramklint, M | 1 |
| Widerström, R | 1 |
| Hellström, PM | 1 |
| Cunningham, JL | 1 |
| Castaño, MY | 1 |
| Garrido, M | 1 |
| Rodríguez, AB | 1 |
| Gómez, MÁ | 1 |
| Alston, M | 1 |
| Cain, SW | 1 |
| Rajaratnam, SMW | 2 |
| Murray, JM | 1 |
| Phillips, AJK | 1 |
| Magee, M | 1 |
| Sletten, TL | 1 |
| Lovato, N | 1 |
| Bei, B | 1 |
| Bartlett, DJ | 1 |
| Kennaway, DJ | 1 |
| Lack, LC | 1 |
| Grunstein, RR | 1 |
| Lockley, SW | 1 |
| Facer-Childs, ER | 1 |
| Middleton, B | 1 |
| Skene, DJ | 1 |
| Bagshaw, AP | 1 |
| Boyce, P | 2 |
| Hopwood, M | 1 |
| Rondanelli, M | 1 |
| Faliva, MA | 1 |
| Perna, S | 1 |
| Antoniello, N | 1 |
| Efron, D | 1 |
| Lycett, K | 1 |
| Sciberras, E | 1 |
| Kulesh, AA | 1 |
| Shestakov, VV | 1 |
| Kostenko, EV | 1 |
| Petrova, LV | 1 |
| Eneeva, MA | 1 |
| Kamchatnov, PR | 1 |
| Uguz, AC | 1 |
| Demirci, K | 1 |
| Espino, J | 1 |
| Giannaccini, G | 1 |
| Masala, I | 1 |
| Palego, L | 1 |
| Betti, L | 1 |
| Pacciardi, B | 1 |
| Luchini, F | 1 |
| Belli, S | 1 |
| Lucacchini, A | 1 |
| Mauri, M | 1 |
| Abelmann, AC | 1 |
| Hatton, SN | 1 |
| Bennett, MR | 1 |
| Lagopoulos, J | 1 |
| Masruha, MR | 1 |
| Lin, J | 1 |
| de Souza Vieira, DS | 1 |
| Minett, TS | 1 |
| Cipolla-Neto, J | 1 |
| Zukerman, E | 1 |
| Vilanova, LC | 1 |
| Peres, MF | 1 |
| Kálmán, J | 1 |
| Kálmán, S | 1 |
| Lewy, AJ | 3 |
| Barriball, E | 1 |
| Lamont, EW | 1 |
| Coutu, DL | 1 |
| Cermakian, N | 1 |
| Boivin, DB | 2 |
| Domínguez-López, S | 1 |
| Mahar, I | 1 |
| Bambico, FR | 1 |
| Labonté, B | 1 |
| Ochoa-Sánchez, R | 1 |
| Leyton, M | 1 |
| Gobbi, G | 1 |
| Milhiet, V | 1 |
| Etain, B | 1 |
| Boudebesse, C | 1 |
| Bellivier, F | 1 |
| Pail, G | 1 |
| Huf, W | 1 |
| Pjrek, E | 1 |
| Winkler, D | 1 |
| Willeit, M | 1 |
| Praschak-Rieder, N | 1 |
| Kasper, S | 1 |
| Srinivasan, V | 3 |
| Zakaria, R | 1 |
| Othaman, Z | 1 |
| Brzezinski, A | 2 |
| Prasad, A | 1 |
| Brown, GM | 3 |
| Shechter, A | 1 |
| Lespérance, P | 1 |
| Ng Ying Kin, NM | 1 |
| De Berardis, D | 1 |
| Shillcutt, SD | 1 |
| Adan, A | 1 |
| Archer, SN | 1 |
| Hidalgo, MP | 1 |
| Di Milia, L | 1 |
| Natale, V | 1 |
| Randler, C | 1 |
| Lanfumey, L | 1 |
| Mongeau, R | 1 |
| Hamon, M | 1 |
| Parry, BL | 6 |
| Sorenson, DL | 1 |
| Meliska, CJ | 2 |
| Basavaraj, N | 1 |
| Zirpoli, GG | 1 |
| Gamst, A | 1 |
| Hauger, R | 1 |
| Kripke, DF | 3 |
| Youngstedt, SD | 1 |
| Rex, KM | 2 |
| Klauber, MR | 2 |
| Elliott, JA | 2 |
| Sprouse, J | 1 |
| Crowley, SJ | 1 |
| Lee, C | 1 |
| Tseng, CY | 1 |
| Fogg, LF | 1 |
| Eastman, CI | 1 |
| Postolache, TT | 1 |
| Hung, TM | 1 |
| Rosenthal, RN | 1 |
| Soriano, JJ | 1 |
| Montes, F | 1 |
| Stiller, JW | 1 |
| Elsenbruch, S | 1 |
| Leppämäki, S | 1 |
| Fernando Martínez, L | 1 |
| Maurer, EL | 1 |
| López, AM | 1 |
| Sorenson, D | 1 |
| Bersani, G | 1 |
| Russo, D | 1 |
| Limpido, L | 1 |
| Marconi, D | 1 |
| Guardiola-Lemaitre, B | 1 |
| Bhattacharjee, Y | 1 |
| Chenevard, R | 1 |
| Suter, Y | 1 |
| Erne, P | 1 |
| Francesca, B | 1 |
| Wahlund, B | 2 |
| Sääf, J | 2 |
| Wetterberg, L | 3 |
| Webb, SM | 1 |
| Puig-Domingo, M | 1 |
| Healy, D | 1 |
| Waterhouse, JM | 1 |
| Leibenluft, E | 1 |
| Fiero, PL | 1 |
| Rubinow, DR | 1 |
| Sandyk, R | 1 |
| Awerbuch, GI | 1 |
| Słowińska-Klencka, D | 1 |
| Lewiński, A | 1 |
| Puigdevall Gallego, V | 1 |
| Laudo Pardos, C | 1 |
| Grahn, H | 1 |
| Nathan, PJ | 1 |
| Burrows, GD | 3 |
| Norman, TR | 4 |
| Morris, K | 1 |
| Newton, RP | 1 |
| Tuunainen, A | 1 |
| Assmus, JD | 1 |
| Langer, RD | 1 |
| Richter, R | 1 |
| Armstrong, SM | 3 |
| Redman, JR | 1 |
| McIntyre, IM | 3 |
| Thompson, C | 2 |
| Stinson, D | 1 |
| Smith, A | 1 |
| Oren, DA | 1 |
| Levitt, AJ | 1 |
| Kennedy, SH | 1 |
| Stern, K | 1 |
| Attar-Levy, D | 1 |
| Lesur, A | 1 |
| Lemperière, T | 1 |
| Gaddy, JR | 1 |
| Stewart, KT | 1 |
| Byrne, B | 1 |
| Doghramji, K | 1 |
| Rollag, MD | 1 |
| Brainard, GC | 1 |
| Johns, M | 1 |
| Judd, FK | 1 |
| Marriott, PM | 1 |
| Golden, RN | 1 |
| Potter, WZ | 1 |
| Weller, EB | 1 |
| Weller, RA | 1 |
| Souêtre, E | 1 |
| Rosenthal, NE | 5 |
| Ortonne, JP | 1 |
| Maurizi, CP | 1 |
| Nurnberger, JI | 1 |
| Berrettini, W | 1 |
| Tamarkin, L | 3 |
| Hamovit, J | 1 |
| Norton, J | 1 |
| Gershon, E | 1 |
| Genhart, M | 1 |
| Jacobsen, FM | 2 |
| Skwerer, RG | 1 |
| Wehr, TA | 3 |
| Miles, A | 1 |
| Philbrick, D | 1 |
| Wurtman, RJ | 1 |
| Sack, DA | 2 |
| James, SP | 3 |
| Arendt, J | 1 |
| Sack, RL | 2 |
| Miller, LS | 1 |
| Hoban, TM | 1 |
| Singer, CM | 2 |
| Samples, JR | 1 |
| Krauss, GL | 1 |
| Mendelson, WB | 1 |
| Sherer, MA | 1 |
| Weingartner, H | 1 |
| Grof, E | 1 |
| Grof, P | 1 |
| Arato, M | 1 |
| Lane, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Melatonin for Adolescent Migraine Prevention Study (The MAP Study).[NCT03150797] | Phase 2 | 72 participants (Actual) | Interventional | 2017-08-02 | Terminated (stopped due to Insufficient Fund) | ||
| A Randomized, Double-Blind, Controlled Trial of Bright Light Therapy on All-Cause Excessive Daytime Sleepiness in Prader-Willi Syndrome[NCT05939453] | 30 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | |||
| Effects of Shift Work on Health: Assessment of Sleep Quality, Motor Control and Cardiovascular Risk.[NCT03453398] | 71 participants (Actual) | Interventional | 2018-01-23 | Completed | |||
| Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)[NCT05965609] | 60 participants (Anticipated) | Interventional | 2023-12-08 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
Change in mean migraine/migrainous days from weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase for each group. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | -1 |
| Placebo Oral Capsule | 0 |
Mean CASQ score in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. The CASQ is a 16-question instrument that uses Likert-like responses and has a score range from 16-80; higher scores indicate greater sleepiness (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | points (Mean) |
|---|---|
| Melatonin 3mg | 33 |
| Melatonin 6mg | 36 |
| Placebo Oral Capsule | 28 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 3 mg vs. placebo. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. melatonin 3 mg. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. placebo. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin treated participants vs. placebo. (Ultimately, as the data were not normally distributed, medians were more appropriate). (NCT03150797)
Timeframe: weeks 5-8 of randomized treatment phase
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Number of days acute medication is used in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to the number of days that medication for the acute treatment of headache was used during the time frame. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 5 |
| Melatonin 6mg | 3 |
| Placebo Oral Capsule | 3 |
Number of headache days in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to number of headache days during the time period--regardless of whether they were migraine or not. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 8 |
| Melatonin 6mg | 4 |
| Placebo Oral Capsule | 5 |
35 reviews available for melatonin and Affective Disorders
| Article | Year |
|---|---|
Molecular Link between Circadian Rhythmicity and Mood Disorders.
Topics: ARNTL Transcription Factors; Circadian Rhythm; Humans; Hydrocortisone; Melatonin; Mood Disorders | 2022 |
[Chronotherapy of affective disorders: principles and clinical aspects].
Topics: Bipolar Disorder; Chronotherapy; Humans; Melatonin; Mood Disorders; Sleep; Sleep Deprivation; Sleep | 2022 |
Circadian insights into the biology of depression: Symptoms, treatments and animal models.
Topics: Animals; Biological Clocks; Circadian Rhythm; Depression; Depressive Disorder; Disease Models, Anima | 2019 |
Insomnia and menopause: a narrative review on mechanisms and treatments.
Topics: Antidepressive Agents; Cognitive Behavioral Therapy; Female; Hormone Replacement Therapy; Humans; Me | 2020 |
Melatonin as a treatment for mood disorders: a systematic review.
Topics: Central Nervous System Depressants; Humans; Melatonin; Mood Disorders; Treatment Outcome | 2017 |
Manipulating melatonin in managing mood.
Topics: Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Sleep Deprivation | 2013 |
Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.
Topics: Animals; Carcinogenesis; Humans; Melatonin; Mood Disorders; Neoplasms; Sleep Disorders, Circadian Rh | 2013 |
The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment.
Topics: Anticonvulsants; Antipsychotic Agents; Circadian Rhythm; Humans; Melatonin; Mitochondria; Mood Disor | 2016 |
[Depression as chronobiological illness].
Topics: Acetamides; Affect; Biological Clocks; Chronotherapy; Circadian Rhythm; Depression; Depressive Disor | 2009 |
Circadian misalignment in mood disturbances.
Topics: Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Sleep; Time Factors | 2009 |
Circadian rhythms and depression.
Topics: Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Family Practice; Female; Humans; Incid | 2010 |
Circadian rhythms and clock genes in psychotic disorders.
Topics: Animals; Bipolar Disorder; Circadian Rhythm; CLOCK Proteins; Glycogen Synthase Kinase 3; Humans; Lit | 2010 |
Circadian biomarkers, circadian genes and bipolar disorders.
Topics: Biological Clocks; Biomarkers; Bipolar Disorder; Body Temperature; Circadian Rhythm; Humans; Melaton | 2011 |
Bright-light therapy in the treatment of mood disorders.
Topics: Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Seasonal | 2011 |
Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders.
Topics: Animals; Central Nervous System Depressants; Humans; Indenes; Melatonin; Mood Disorders; Sleep Initi | 2012 |
Role of melatonin in mood disorders and the antidepressant effects of agomelatine.
Topics: Acetamides; Animals; Antidepressive Agents; Humans; Melatonin; Mood Disorders | 2012 |
Circadian typology: a comprehensive review.
Topics: Aging; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Cognition; Feeding and Eating Di | 2012 |
Biological rhythms and melatonin in mood disorders and their treatments.
Topics: Acetamides; Animals; Antidepressive Agents; Brain; Chronobiology Disorders; Circadian Rhythm; Humans | 2013 |
Pharmacological modulation of circadian rhythms: a new drug target in psychotherapeutics.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Casein Kinase 1 epsilon; Casein Kinase Idelta; | 2004 |
Sports chronobiology consultation: from the lab to the arena.
Topics: Altitude; Biological Clocks; Central Nervous System Stimulants; Chronobiology Phenomena; Circadian R | 2005 |
[Light and mood therapy].
Topics: Female; Finland; Humans; Male; Melatonin; Mood Disorders; Phototherapy; Prognosis; Risk Factors; Sea | 2005 |
Sleep, rhythms and women's mood. Part II. Menopause.
Topics: Adult; Circadian Rhythm; Female; Hormone Replacement Therapy; Hot Flashes; Humans; Hydrocortisone; M | 2006 |
[Melatoninergic receptor agonists and antagonists: therapeutic perspectives].
Topics: Antidepressive Agents; Body Temperature; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Mood | 2007 |
Role of melatonin in health and disease.
Topics: Adult; Circadian Rhythm; Female; Humans; Infant; Light; Male; Melatonin; Mood Disorders; Pineal Glan | 1995 |
The circadian system and the therapeutics of the affective disorders.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Behavior Therapy; Bipolar Disorder; Circadian | 1995 |
Effects of the menstrual cycle on dependent variables in mood disorder research.
Topics: Adult; beta-Endorphin; Body Temperature; Circadian Rhythm; Depressive Disorder; Female; Growth Hormo | 1994 |
[Role of melatonin in human physiology and pathology. II. Involvement of melatonin in pathogenesis of affective and chronobiological disorders. Melatonin and the aging process. Melatonin and neoplasms].
Topics: Aging; Chronobiology Phenomena; Humans; Melatonin; Mood Disorders; Neoplasms | 1993 |
Melatonin, biological rhythm disorders and phototherapy.
Topics: Body Fluids; Circadian Rhythm; Humans; Hypothalamus; Melatonin; Mood Disorders; Neurotransmitter Age | 1997 |
The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications.
Topics: Animals; Antidepressive Agents, Second-Generation; Biogenic Monoamines; Clinical Trials as Topic; De | 2001 |
Chronobiological basis of female-specific mood disorders.
Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P | 2001 |
Retinal melatonin and dopamine in seasonal affective disorder.
Topics: Animals; Circadian Rhythm; Dopamine; Gene Expression Regulation; Humans; Hypothalamo-Hypophyseal Sys | 1991 |
Neuroendocrine changes in affectively ill children and adolescents.
Topics: Adolescent; Child; Child, Preschool; Dexamethasone; Growth Hormone; Humans; Hydrocortisone; Melatoni | 1988 |
Disturbances of appetite and weight regulation in seasonal affective disorder.
Topics: Body Weight; Depression; Dietary Carbohydrates; Feeding and Eating Disorders; Feeding Behavior; Fema | 1987 |
Melatonin: perspectives in laboratory medicine and clinical research.
Topics: Brain Neoplasms; Breast Neoplasms; Humans; Male; Melanoma; Melatonin; Mood Disorders; Prostatic Neop | 1987 |
Light therapy for depression: present status, problems, and perspectives.
Topics: Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Placebos; Seasons | 1986 |
7 trials available for melatonin and Affective Disorders
| Article | Year |
|---|---|
Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder.
Topics: Adult; Australia; Biological Variation, Population; Case-Control Studies; Central Nervous System Dep | 2019 |
Resetting the late timing of 'night owls' has a positive impact on mental health and performance.
Topics: Actigraphy; Adult; Circadian Rhythm; Female; Humans; Hydrocortisone; Male; Melatonin; Mental Health; | 2019 |
Use of sleep medication in children with ADHD.
Topics: Adolescent; Anxiety Disorders; Attention Deficit and Disruptive Behavior Disorders; Attention Defici | 2014 |
Effects of the heart-lung machine on melatonin metabolism and mood disturbances.
Topics: Aged; Cardiac Surgical Procedures; Chronobiology Disorders; Circadian Rhythm; Female; Heart-Lung Mac | 2008 |
Chronobiological basis of female-specific mood disorders.
Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P | 2001 |
Seasonal affective disorder and season-dependent abnormalities of melatonin suppression by light.
Topics: Adult; Evaluation Studies as Topic; Female; Humans; Light; Male; Melatonin; Middle Aged; Mood Disord | 1990 |
Melatonin in seasonal affective disorder and phototherapy.
Topics: Animals; Circadian Rhythm; Humans; Light; Melatonin; Mood Disorders; Phototherapy; Pineal Gland; Sea | 1986 |
48 other studies available for melatonin and Affective Disorders
| Article | Year |
|---|---|
Circadian Rhythms in Mood Disorders.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Mice; Mood Disorders; Pituitary-Adrenal System; Sleep | 2021 |
Topics: Adolescent; Adult; Aged; Alcoholism; Anhedonia; Antiphospholipid Syndrome; Anxiety; Comorbidity; Dep | 2022 |
Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders.
Topics: Actigraphy; Adolescent; Adult; Anxiety Disorders; Body Temperature; Circadian Rhythm; Female; Humans | 2017 |
The Relationship Between Daytime Salivary Melatonin and Gastrointestinal Symptoms in Young Adults Seeking Psychiatric Care.
Topics: Adolescent; Adult; Anxiety Disorders; Circadian Rhythm; Comorbidity; Female; Humans; Irritable Bowel | 2019 |
Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia.
Topics: Adult; Analgesics; Female; Fibromyalgia; Humans; Hydrocortisone; Male; Melatonin; Middle Aged; Mood | 2019 |
Advances of Melatonin-Based Therapies in the Treatment of Disturbed Sleep and Mood.
Topics: Circadian Rhythm; Depressive Disorder, Major; Humans; Melatonin; Mood Disorders; Sleep; Sleep Initia | 2019 |
[Poststroke cognitive, emotional impairment and sleep quality: efficience of treatment with melaxen].
Topics: Adult; Aged; Anxiety; Cognition; Cognition Disorders; Emotions; Female; Humans; Male; Melatonin; Mid | 2014 |
[Sleep disorders and circadian rhythms in diseases of the cardiovascular system].
Topics: Aged; Cardiovascular Diseases; Circadian Rhythm; Cognition Disorders; Female; Humans; Male; Melatoni | 2015 |
Melatonin and pro-hypnotic effectiveness of the antidepressant Trazodone: A preliminary evaluation in insomniac mood-disorder patients.
Topics: Adult; Antidepressive Agents; Chromatography, High Pressure Liquid; Female; Humans; Hypnotics and Se | 2016 |
Pineal volume and evening melatonin in young people with affective disorders.
Topics: Actigraphy; Adolescent; Adult; Circadian Rhythm; Female; Humans; Image Processing, Computer-Assisted | 2017 |
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul | 2010 |
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul | 2010 |
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul | 2010 |
Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Biomarkers; Comorbidity; Depressive Disorder; Down-Regul | 2010 |
Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Idazoxan; Male; Melatonin; Mood Disorders; Neurons | 2012 |
Nocturnal polysomnographic sleep across the menstrual cycle in premenstrual dysphoric disorder.
Topics: Adult; Body Temperature; Circadian Rhythm; Female; Follicular Phase; Humans; Luteal Phase; Melatonin | 2012 |
Hormonal basis of mood and postpartum disorders.
Topics: Adult; Case-Control Studies; Depression, Postpartum; Estrogens; Female; Hormones; Humans; Hydrocorti | 2003 |
Melatonin excretion with affect disorders over age 60.
Topics: Aged; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Mood Disorders | 2003 |
Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work.
Topics: Adolescent; Adult; Arousal; Body Temperature; Circadian Rhythm; Cognition Disorders; Disorders of Ex | 2004 |
Melatonin: a novel treatment for IBS?
Topics: Adaptation, Physiological; Humans; Irritable Bowel Syndrome; Melatonin; Mood Disorders; Polysomnogra | 2005 |
Mood disorder in a patient with Smith-Magenis syndrome: a case report.
Topics: Adult; Chromosomes, Human, Pair 17; Craniofacial Abnormalities; Female; Gene Deletion; Humans; Intel | 2007 |
Psychiatric research. Is internal timing key to mental health?
Topics: Animals; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Clinical Trials as Topic; Hum | 2007 |
Circadian rhythms of hormones in primary affective disorders.
Topics: Circadian Rhythm; Gonadotropins, Pituitary; Growth Hormone; Hormones; Humans; Hypothalamo-Hypophysea | 1983 |
Classification of patients with affective disorders using platelet monoamine oxidase activity, serum melatonin and post-dexamethasone cortisol.
Topics: Adult; Age Factors; Blood Platelets; Body Height; Body Weight; Dexamethasone; Female; Humans; Hydroc | 1995 |
Multiple sclerosis: the role of the pineal gland in its timing of onset and risk of psychiatric illness.
Topics: Adolescent; Adult; Age of Onset; Aged; Female; Humans; Male; Melanins; Melatonin; Mental Disorders; | 1993 |
[Melatonin: use and abuse].
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Antioxidants; Child; Circadian Rhythm; Contraceptives, | 1997 |
Affective disorder subtyped by psychomotor symptoms, monoamine oxidase, melatonin and cortisol: identification of patients with latent bipolar disorder.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Hydrocortisone; Male; Melatonin; Middl | 1998 |
Melatonin sensitivity to dim white light in affective disorders.
Topics: Adolescent; Adult; Aged; Biomarkers; Bipolar Disorder; Depressive Disorder, Major; Humans; Light; Me | 1999 |
New day dawns for research on circadian rhythms.
Topics: Affect; Biological Clocks; Circadian Rhythm; Feedback; Free Radical Scavengers; Humans; Lighting; Me | 1999 |
Depression and endogenous melatonin in postmenopausal women.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Depressive Disorder, Major; Female; Humans; Melatonin; | 2002 |
Seasonality in biochemical determinations: a source of variance and a clue to the temporal incidence of affective illness.
Topics: Adult; Biological Clocks; Dopamine beta-Hydroxylase; Female; Humans; Male; Melatonin; Mood Disorders | 1979 |
Melatonin: a chronobiotic with anti-aging properties?
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Diptera; Feedback; Female; Humans; Immune System; Male | 1991 |
Melatonin supersensitivity to dim light in seasonal affective disorder.
Topics: Female; Humans; Melatonin; Middle Aged; Mood Disorders; Phototherapy; Seasons | 1990 |
Tryptophan treatment and melatonin response in a patient with seasonal affective disorder.
Topics: Female; Humans; Melatonin; Middle Aged; Mood Disorders; Seasons; Tryptophan | 1991 |
[Seasonal affective disorders, a new clinical category].
Topics: Adult; Circadian Rhythm; Female; Humans; Light; Melatonin; Mood Disorders; Phototherapy; Seasons | 1990 |
Light-induced plasma melatonin suppression in seasonal affective disorder.
Topics: Female; Humans; Light; Male; Melatonin; Mood Disorders; Radioimmunoassay; Seasons | 1990 |
A portable light source for bright light treatment.
Topics: Adult; Circadian Rhythm; Humans; Lighting; Male; Melatonin; Mood Disorders; Phototherapy; Sleep Wake | 1990 |
Plasma melatonin levels in affective states.
Topics: Adolescent; Adult; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Mood Disorders | 1989 |
Neurochemical and neuroendocrine dysregulation in affective disorders.
Topics: Acetylcholine; Anxiety Disorders; Arousal; Brain; Depressive Disorder; Hormones; Humans; Melatonin; | 1986 |
Affective disorders, light and melatonin.
Topics: Animals; Darkness; Humans; Melatonin; Mood Disorders; Seasons; Sunlight | 1988 |
Why not treat melancholia with melatonin and tryptophan and treat seasonal affective disorders with bright light?
Topics: Biomarkers; Depressive Disorder; Humans; Melatonin; Models, Biological; Mood Disorders; Phototherapy | 1988 |
Supersensitivity to melatonin suppression by light in young people at high risk for affective disorder. A preliminary report.
Topics: Adolescent; Adult; Biomarkers; Bipolar Disorder; Female; Humans; Light; Male; Melatonin; Mood Disord | 1988 |
Melatonin in humans.
Topics: Adult; Animals; Child; Circadian Rhythm; Darkness; Humans; Light; Melatonin; Mood Disorders; Pineal | 1986 |
The use of plasma melatonin levels and light in the assessment and treatment of chronobiologic sleep and mood disorders.
Topics: Biological Clocks; Humans; Intraocular Pressure; Light; Melatonin; Mood Disorders; Phototherapy; Sea | 1986 |
Melatonin and affective disorders.
Topics: Cluster Headache; Darkness; Depression; Humans; Hypothalamo-Hypophyseal System; Light; Melatonin; Mo | 1985 |
Seasonal affective disorder and phototherapy.
Topics: Adult; Body Weight; Electroencephalography; Female; Humans; Male; Melatonin; Mood Disorders; Phototh | 1985 |
Therapeutic effects of bright light in depressed patients.
Topics: Animals; Dexamethasone; Female; Humans; Hyperphagia; Light; Male; Melatonin; Models, Biological; Moo | 1985 |
Circadian rhythms.
Topics: Circadian Rhythm; Humans; Melatonin; Mood Disorders | 1985 |
Treating phase typed chronobiologic sleep and mood disorders using appropriately timed bright artificial light.
Topics: Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Seasons; Sleep Wake Disorders | 1985 |
Effects of melatonin on performance testing in patients with seasonal affective disorder.
Topics: Arousal; Attention; Cognition; Humans; Melatonin; Mood Disorders; Psychomotor Performance; Reaction | 1985 |
Investigations of melatonin secretion in man.
Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Lithium; Male; Melatonin; Middle Aged; Mood Dis | 1985 |