melatonin has been researched along with Adverse Drug Event in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " We will include randomised clinical trials comparing melatonin versus placebo or no intervention for sleep disorders in children with neurodevelopmental disorders." | 9.51 | Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. ( Faltermeier, P; Gluud, C; Hermann, R; Horowitz, M; Jakobsen, JC; Juul, S; Jørgensen, CK; Moncrieff, J, 2022) |
| " In a dose-response manner, melatonin also reduced vestibular hair cell loss due to gentamicin treatment in explanted utricles of newborn rats." | 6.47 | Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. ( Fuentes-Broto, L; Korkmaz, A; Reiter, RJ; Tan, DX, 2011) |
| " We will include randomised clinical trials comparing melatonin versus placebo or no intervention for sleep disorders in children with neurodevelopmental disorders." | 5.51 | Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. ( Faltermeier, P; Gluud, C; Hermann, R; Horowitz, M; Jakobsen, JC; Juul, S; Jørgensen, CK; Moncrieff, J, 2022) |
| "Exposure to 60-Hz magnetic fields may increase breast cancer risk by suppressing the nocturnal production of melatonin." | 3.74 | Residential magnetic fields, medication use, and the risk of breast cancer. ( Davis, S; Mirick, DK, 2007) |
| "In this study, we investigated the effects of melatonin on adriamycin-induced cardiotoxicity both in vivo in rats and in vitro, and on the antitumor activities of adriamycin on MDA-231 and NCI breast cancer cells." | 3.73 | Modulation by melatonin of the cardiotoxic and antitumor activities of adriamycin. ( Cuong, DV; Han, J; Joo, H; Kim, C; Kim, E; Kim, N; Min, CK; Park, WS; Park, YS; Youm, JB, 2005) |
| "Primary outcomes were the change in visual fatigue score and critical flicker-fusion frequency (CFF), as continuous outcomes, between baseline and one month of follow-up." | 3.01 | Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults. ( Busija, L; Downie, LE; Hull, CC; Keller, PR; Lawrenson, JG; Makrai, E; McMillan, P; Singh, S, 2023) |
| "Melatonin is a pleotropic molecule with numerous biological activities." | 2.72 | Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities. ( Abuawad, A; Alsayed, AR; Daoud, S; Mahmod, AI; Talib, WH, 2021) |
| " We examined controlled studies of oral melatonin supplementation in humans when they presented any statistical analysis of adverse events." | 2.61 | Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence. ( Foley, HM; Steel, AE, 2019) |
| " In a dose-response manner, melatonin also reduced vestibular hair cell loss due to gentamicin treatment in explanted utricles of newborn rats." | 2.47 | Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. ( Fuentes-Broto, L; Korkmaz, A; Reiter, RJ; Tan, DX, 2011) |
| "Melatonin has been shown to have a variety of functions, and research in the last decade has proven the indole to be both a direct free radical scavenger and indirect antioxidant." | 2.41 | Melatonin: reducing the toxicity and increasing the efficacy of drugs. ( Lopez-Burillo, S; Mayo, JC; Reiter, RJ; Sainz, RM; Tan, DX, 2002) |
| "Busulfan is a widely used chemotherapeutic drug for chronic myelogenous leukemia and bone marrow transplantation." | 1.51 | Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. ( Lin, Z; Mi, J; Song, H; Sun, Z; Wei, R; Xia, Q; Yang, Y; Zhang, X; Zou, K, 2019) |
| "Melatonin has been shown to palliate different lesions by scavenging free radicals, but its role in the reduction of the fluoxetine-induced injuries has been little known." | 1.46 | Protective effects of melatonin on long-term administration of fluoxetine in rats. ( Khaksar, M; Oryan, A; Rahbarghazi, R; Rezabakhsh, A; Sayyari, M, 2017) |
| "Sleep disorders are interrelated with medical and psychiatric illnesses." | 1.35 | Sleep disorders: causes, effects, and solutions. ( Tibbitts, GM, 2008) |
| "Melatonin is a highly effective treatment in different animal models of excitotoxicity or ischemia/reperfusion injury." | 1.33 | Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration. ( Chan, PS; Cheung, RT; Ma, ES; Tam, S; Tipoe, GL; Zou, LY, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 5 (18.52) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Jørgensen, CK | 3 |
| Hermann, R | 3 |
| Juul, S | 3 |
| Faltermeier, P | 3 |
| Horowitz, M | 3 |
| Moncrieff, J | 3 |
| Gluud, C | 3 |
| Jakobsen, JC | 3 |
| Singh, S | 1 |
| Keller, PR | 1 |
| Busija, L | 1 |
| McMillan, P | 1 |
| Makrai, E | 1 |
| Lawrenson, JG | 1 |
| Hull, CC | 1 |
| Downie, LE | 1 |
| Campbell, S | 1 |
| Otten, H | 1 |
| Anand, V | 1 |
| Yang, Z | 1 |
| He, Y | 1 |
| Ma, Q | 1 |
| Wang, H | 1 |
| Zhang, Q | 1 |
| Talib, WH | 1 |
| Alsayed, AR | 1 |
| Abuawad, A | 1 |
| Daoud, S | 1 |
| Mahmod, AI | 1 |
| Khaksar, M | 1 |
| Oryan, A | 1 |
| Sayyari, M | 1 |
| Rezabakhsh, A | 1 |
| Rahbarghazi, R | 1 |
| Ouitou, Y | 1 |
| Foley, HM | 1 |
| Steel, AE | 1 |
| Zhang, X | 1 |
| Xia, Q | 1 |
| Wei, R | 1 |
| Song, H | 1 |
| Mi, J | 1 |
| Lin, Z | 1 |
| Yang, Y | 1 |
| Sun, Z | 1 |
| Zou, K | 1 |
| Tibbitts, GM | 1 |
| Reiter, RJ | 5 |
| Korkmaz, A | 2 |
| Paredes, SD | 2 |
| Manchester, LC | 2 |
| Tan, DX | 5 |
| Tobaiqy, M | 1 |
| Stewart, D | 1 |
| Helms, PJ | 1 |
| Bond, C | 1 |
| Lee, AJ | 1 |
| Bateman, N | 1 |
| McCaig, D | 1 |
| McLay, J | 1 |
| Fuentes-Broto, L | 2 |
| Boyko, Y | 1 |
| Ording, H | 1 |
| Jennum, P | 1 |
| Kennaway, DJ | 1 |
| Sainz, RM | 1 |
| Mayo, JC | 1 |
| Lopez-Burillo, S | 1 |
| Kim, C | 1 |
| Kim, N | 1 |
| Joo, H | 1 |
| Youm, JB | 1 |
| Park, WS | 1 |
| Cuong, DV | 1 |
| Park, YS | 1 |
| Kim, E | 1 |
| Min, CK | 1 |
| Han, J | 1 |
| Cheung, RT | 1 |
| Tipoe, GL | 1 |
| Tam, S | 1 |
| Ma, ES | 1 |
| Zou, LY | 1 |
| Chan, PS | 1 |
| Maldonado, MD | 1 |
| Murillo-Cabezas, F | 1 |
| Terron, MP | 1 |
| Flores, LJ | 1 |
| Davis, S | 1 |
| Mirick, DK | 1 |
| Wolkove, N | 1 |
| Elkholy, O | 1 |
| Baltzan, M | 1 |
| Palayew, M | 1 |
| Garfinkel, D | 1 |
| Laudon, M | 1 |
| Nof, D | 1 |
| Zisapel, N | 1 |
| Shannon, M | 1 |
| Kuntzman, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease[NCT04287543] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2021-05-31 | Withdrawn (stopped due to Due to the COVID-19 pandemic, we were unable to begin the study) | ||
| Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation[NCT04547439] | Phase 2 | 36 participants (Anticipated) | Interventional | 2021-02-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for melatonin and Adverse Drug Event
| Article | Year |
|---|---|
Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults.
Topics: Adult; Asthenopia; Drug-Related Side Effects and Adverse Reactions; Eyeglasses; Humans; Light; Melat | 2023 |
Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.
Topics: Apoptosis; Cell Proliferation; Drug-Related Side Effects and Adverse Reactions; Humans; Melatonin; N | 2021 |
Clock desynchronisation: why and how?
Topics: Alcohol Drinking; Animals; Chronobiology Disorders; Circadian Clocks; Drug-Related Side Effects and | 2015 |
Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence.
Topics: Administration, Oral; Animals; Drug-Related Side Effects and Adverse Reactions; Humans; Melatonin | 2019 |
Melatonin reduces oxidative/nitrosative stress due to drugs, toxins, metals, and herbicides.
Topics: Animals; Antioxidants; Drug-Related Side Effects and Adverse Reactions; Herbicides; Humans; Melatoni | 2008 |
Beneficial effects of melatonin in cardiovascular disease.
Topics: Animals; Antioxidants; Cardiotonic Agents; Cardiovascular Diseases; Drug-Related Side Effects and Ad | 2010 |
Drug-mediated ototoxicity and tinnitus: alleviation with melatonin.
Topics: Aminoglycosides; Animals; Cisplatin; Controlled Clinical Trials as Topic; Drug-Related Side Effects | 2011 |
Sleep disturbances in critically ill patients in ICU: how much do we know?
Topics: Adult; Aged; Critical Care; Critical Illness; Drug-Related Side Effects and Adverse Reactions; Femal | 2012 |
Programming of the fetal suprachiasmatic nucleus and subsequent adult rhythmicity.
Topics: Animals; Birth Weight; Body Height; Circadian Rhythm; Drug-Related Side Effects and Adverse Reaction | 2002 |
Melatonin: reducing the toxicity and increasing the efficacy of drugs.
Topics: Animals; Antioxidants; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Hum | 2002 |
The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma.
Topics: Craniocerebral Trauma; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Hum | 2007 |
Sleep and aging: 2. Management of sleep disorders in older people.
Topics: Adjuvants, Immunologic; Aged; Aging; Antidepressive Agents; Behavior Therapy; Benzodiazepines; Demen | 2007 |
Alternative medicines toxicology: a review of selected agents.
Topics: Aphrodisiacs; Complementary Therapies; Drug-Related Side Effects and Adverse Reactions; Humans; Mela | 1999 |
Drugs and enzyme induction.
Topics: Animals; Bilirubin; Blood Proteins; Cytochromes; Drug Synergism; Drug Therapy; Drug-Related Side Eff | 1969 |
2 trials available for melatonin and Adverse Drug Event
11 other studies available for melatonin and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
CYP450 Genetic Polymorphisms: Generalized Tonic-Clonic Seizure after Intentional Fluoxetine and Melatonin Overdose.
Topics: Cytochrome P-450 Enzyme System; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fluo | 2023 |
Alleviative effect of melatonin against the nephrotoxicity induced by cadmium exposure through regulating renal oxidative stress, inflammatory reaction, and fibrosis in a mouse model.
Topics: Animals; Cadmium; Drug-Related Side Effects and Adverse Reactions; Fibrosis; Humans; Inflammation; K | 2023 |
Protective effects of melatonin on long-term administration of fluoxetine in rats.
Topics: Animals; Antioxidants; Body Weight; Drug-Related Side Effects and Adverse Reactions; Erythrocyte Cou | 2017 |
Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Apoptosis; Busulfan; Cells, Cultured; Drug | 2019 |
Sleep disorders: causes, effects, and solutions.
Topics: Behavior Therapy; Chronobiology Disorders; Drug Interactions; Drug-Related Side Effects and Adverse | 2008 |
A pilot study to evaluate a community pharmacy-based monitoring system to identify adverse drug reactions associated with paediatric medicines use.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Anticonvulsants; Atomoxetine Hydrochloride; Chi | 2010 |
Modulation by melatonin of the cardiotoxic and antitumor activities of adriamycin.
Topics: Animals; Antibiotics, Antineoplastic; Body Weight; Breast Neoplasms; Cell Line, Tumor; Comet Assay; | 2005 |
Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration.
Topics: Animals; Blood Cell Count; Blood Pressure; Body Temperature; Body Weight; Brain; Drug Evaluation, Pr | 2006 |
Residential magnetic fields, medication use, and the risk of breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Case-Control Studies; Circadian Rhythm; Drug-Related Side Effects and | 2007 |