melatonin and Advanced Sleep Phase Syndrome studies

Research Excerpts

Excerpt	Relevance	Reference
" All papers on melatonin treatment in dementia were retrieved."	8.86	Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010)
"Melatonin is used to treat sleep disorders in both children and adults with intellectual disability (ID), although it has no product license for such use."	8.84	Melatonin and sleep disorders associated with intellectual disability: a clinical review. ( Clarke, D; Sajith, SG, 2007)
"Sleep disturbances, abnormal melatonin secretion, and increased inflammation are aspects of autism spectrum disorder (ASD) pathophysiology."	8.02	Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances. ( Anderson, G; da Silveira Cruz-Machado, S; Fadini, CC; Guissoni Campos, LM; Markus, RP; Pinato, L, 2021)
"To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR)."	7.91	Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy. ( Andersen, HU; Ba-Ali, S; Brøndsted, AE; Jennum, PJ; Lund-Andersen, H; Sander, B, 2019)
"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."	7.91	Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies."	7.73	Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin. ( Abad, A; Carpizo, R; González, M; Martínez, A; Mediavilla, D; Sánchez-Barceló, EJ, 2006)
"Small doses of melatonin were administrated to 30 patients with day/night rhythm disorders, after cerebral stroke."	7.70	[Melatonin in sleep rhythm disorders after cerebral stroke]. ( Domzał, TM; Kaca-Oryńska, M; Zaleski, P, 2000)
"Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime."	6.71	Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."	6.46	Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"Treatment with melatonin up to 14 mg at bedtime was initiated with complete realignment of the sleep-wake rhythm (tau 23."	5.46	Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst. ( Antelmi, E; Ferri, L; Filardi, M; Moresco, M; Pierangeli, G; Pizza, F; Plazzi, G; Toni, F; Vandi, S; Zucchelli, M, 2017)
"Williams-Beuren syndrome (WBS), a neurodevelopmental disorder caused by a microdeletion on chromosomic region 7q11."	5.43	Correlations between behavior, memory, sleep-wake and melatonin in Williams-Beuren syndrome. ( Campos, LM; Giacheti, CM; Pinato, L; Rossi, NF; Santoro, SD, 2016)
"Melatonin treatment significantly reduced depression scores in the depressed patients as measured by the CES-D and Hamilton Depression Rating Scale--17."	5.14	Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. ( Kayumov, L; Rahman, SA; Shapiro, CM, 2010)
" These have been variously attributed to hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pathophysiology remains limited and their treatment problematic."	4.90	Sleep-wake abnormalities in patients with cirrhosis. ( Amodio, P; Corrias, M; Costa, R; De Pittà, C; De Rui, M; Gatta, A; Merkel, C; Montagnese, S; Skene, DJ; Turco, M, 2014)
"PubMed database was searched systematically for articles that were published on or before May 5, 2013, and were written in English using the terms bipolar disorder, clock genes, endogenous clock, molecular clock, biological rhythms, circadian, suprachiasmatic nucleus, circadian rhythm, melatonin, and sleep."	4.90	The relationship between bipolar disorder and biological rhythms. ( Gonzalez, R, 2014)
" We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol and melatonin), and we assess the implications for CT and adjustment to shiftwork and jet lag."	4.88	Circadian typology: a comprehensive review. ( Adan, A; Archer, SN; Di Milia, L; Hidalgo, MP; Natale, V; Randler, C, 2012)
" All papers on melatonin treatment in dementia were retrieved."	4.86	Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010)
"Melatonin is used to treat sleep disorders in both children and adults with intellectual disability (ID), although it has no product license for such use."	4.84	Melatonin and sleep disorders associated with intellectual disability: a clinical review. ( Clarke, D; Sajith, SG, 2007)
"Sleep disturbances, abnormal melatonin secretion, and increased inflammation are aspects of autism spectrum disorder (ASD) pathophysiology."	4.02	Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances. ( Anderson, G; da Silveira Cruz-Machado, S; Fadini, CC; Guissoni Campos, LM; Markus, RP; Pinato, L, 2021)
"To investigate potential delays in endogenous melatonin in individuals with obsessive-compulsive disorder (OCD)."	3.96	Sleep duration and timing in obsessive-compulsive disorder (OCD): evidence for circadian phase delay. ( Coles, ME; Deak, M; Schubert, J; Sharkey, KM; Stewart, E, 2020)
"To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR)."	3.91	Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy. ( Andersen, HU; Ba-Ali, S; Brøndsted, AE; Jennum, PJ; Lund-Andersen, H; Sander, B, 2019)
"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."	3.91	Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"To study disturbances of sleep and circadian rhythms in patients with cardiovascular diseases taking into account the level of melatonin secretion and to optimize a complex approach to their treatment."	3.81	[Sleep disorders and circadian rhythms in diseases of the cardiovascular system]. ( Eneeva, MA; Kamchatnov, PR; Kostenko, EV; Petrova, LV, 2015)
"We examined the relationship between sleep-wake activity, recorded actigraphically over 6 weeks, along with ambient light exposure and simultaneous circadian clock timing, by collecting weekly 48 h profiles of a urinary metabolite of melatonin in 20 out-patients with schizophrenia and 21 healthy control individuals matched for age, gender and being unemployed."	3.78	Sleep and circadian rhythm disruption in schizophrenia. ( Dijk, DJ; Foster, RG; Joyce, EM; Middleton, B; Wulff, K, 2012)
"Fourteen middle-aged individuals diagnosed with schizophrenia underwent continuous wrist actimetry monitoring in real-life settings for 3 weeks, and collected saliva samples to determine the onset of endogenous melatonin secretion as a circadian phase marker."	3.77	Sleep-wake cycles and cognitive functioning in schizophrenia. ( Bromundt, V; Cajochen, C; Georgiev-Kill, A; Köster, M; Opwis, K; Stoppe, G; Wirz-Justice, A, 2011)
"This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies."	3.73	Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin. ( Abad, A; Carpizo, R; González, M; Martínez, A; Mediavilla, D; Sánchez-Barceló, EJ, 2006)
"A patient with Gilles de la Tourette syndrome treated with haloperidol, ingested once daily after awakening from sleep, exhibited an irregular sleep-wake pattern with a free-running component of approximately 48 h."	3.71	Case study of circadian rhythm sleep disorder following haloperidol treatment: reversal by risperidone and melatonin. ( Ayalon, L; Dagan, Y; Hermesh, H, 2002)
"Small doses of melatonin were administrated to 30 patients with day/night rhythm disorders, after cerebral stroke."	3.70	[Melatonin in sleep rhythm disorders after cerebral stroke]. ( Domzał, TM; Kaca-Oryńska, M; Zaleski, P, 2000)
"This study reports on melatonin treatment in autism."	3.70	Effect of melatonin on sleep-wake rhythm: the sleep diary of an autistic male. ( Hayashi, E, 2000)
"Melatonin has also been found to have anticonvulsant and neuroprotective properties by adjusting the circadian rhythm."	3.11	Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. ( Chen, J; Feng, W; Liu, M; Shi, X; Sun, Y; Wang, J; Xu, T; Yang, G; Zou, L, 2022)
"Despite the separation of insomnia and circadian rhythm disorders in diagnostic nosology implying independent pathophysiology, there is considerable evidence of co-morbidity and interaction between them."	3.01	Circadian aspects in the aetiology and pathophysiology of insomnia. ( Lack, LC; Lovato, N; Micic, G, 2023)
"The main clinical manifestations are insomnia and excessive daytime sleepiness that often lead to clinically meaningful distress or cause mental, physical, social, occupational, educational, or other functional impairment."	2.82	Treatment of Circadian Rhythm Sleep-Wake Disorders. ( Chen, GH; Sun, SY, 2022)
"The outcomes showed decreased daytime sleepiness, lessened sleep onset latency, diminished night-time awakenings, increased total sleep period and improved daytime attention in the melatonin-treated group; (4) Conclusions: Exogenously administered melatonin is effective in shift worker health personnel that are suffering from sleep disorders, and given its low adverse effects and tolerability, it might be recommended."	2.82	The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. ( Cantón-Manzano, C; Carriedo-Diez, B; Sanz-Valero, J; Tosoratto-Venturi, JL; Wanden-Berghe, C, 2022)
"Melatonin treatment during Trial 2 led to an improvement in the subjective sleep difficulty between the pre- and post-treatment surveys; however there were no significant differences in the objective measures of sleep."	2.80	Sleep deficits in the High Arctic summer in relation to light exposure and behaviour: use of melatonin as a countermeasure. ( Arendt, J; Brett, K; Hawton, A; Love, RJ; McCreary, DR; Paul, MA, 2015)
"Caffeine treatment significantly improved daytime alertness at adverse circadian phases (p <0."	2.80	Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms. ( Lockley, SW; St Hilaire, MA, 2015)
"Melatonin secretion was assayed for each individual by ELISA using saliva samples."	2.74	Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome. ( Kayumov, L; Rahman, SA; Shapiro, CM; Tchmoutina, EA, 2009)
"Treatment with melatonin resulted in an improvement of subjective and objective sleep parameters, as well as a recovered nocturnal melatonin rhythm."	2.74	The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study). ( Boringa, JB; Hagen, EC; Kerkhof, GA; Koch, BC; Nagtegaal, JE; Ter Wee, PM; van der Westerlaken, MM, 2009)
"However, unlike many patients with insomnia, those with DSPD struggle to get up at appropriate times."	2.72	Just Let Me Sleep in: Identifying and Treating Delayed Sleep Phase Disorder in Adolescents. ( Baroni, A; Feder, MA, 2021)
"Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime."	2.71	Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004)
"People with autism spectrum disorder (ASD) commonly experience other comorbidities."	2.66	Sleep in autism: A biomolecular approach to aetiology and treatment. ( Baker, EK; Ballester, P; Peiró, AM; Richdale, AL, 2020)
"Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies."	2.55	Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. ( Auld, F; Maschauer, EL; Morrison, I; Riha, RL; Skene, DJ, 2017)
" Management includes timed melatonin along with optional timed and dosed bright light exposure."	2.55	Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. ( Burman, D, 2017)
"Treatment of circadian rhythm sleep disorders (CRSD) may include light therapy, chronotherapy and melatonin."	2.50	Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders. ( Curfs, LM; Duffy, JF; Keijzer, H; Smits, MG, 2014)
"Modafinil probably has similar effects on sleepiness (KSS) (MD -0."	2.50	Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. ( Costa, G; Driscoll, TR; Isotalo, LK; Liira, J; Ruotsalainen, JH; Sallinen, M; Verbeek, JH, 2014)
"The molecular effects of chronic sleep deprivation and circadian misalignment are currently being explored as potential mechanistic markers of the deleterious health consequences associated with these states."	2.50	Out of synch with society: an update on delayed sleep phase disorder. ( Dijk, DJ; Nesbitt, AD, 2014)
"sleep and mood), immune function, cancer initiation and growth, as well as the correlation between melatonin levels and cancer risk, are hereinafter recorded and summarized."	2.49	Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks. ( Antoniello, N; Faliva, MA; Perna, S; Rondanelli, M, 2013)
"Delayed sleep phase disorder (DSPD) - a circadian rhythm sleep disorder - is most commonly seen in adolescents."	2.49	Circadian rhythm disorders among adolescents: assessment and treatment options. ( Armstrong, SM; Bartlett, DJ; Biggs, SN, 2013)
"Primary pathophysiology of circadian rhythm sleep disorders(CRSDs) is a misalignment between the endogenous circadian rhythm phase and the desired or socially required sleep-wake schedule, or dysfunction of the circadian pacemaker and its afferent/efferent pathways."	2.49	[Circadian rhythm sleep disorder]. ( Mishima, K, 2013)
"This article reviews circadian rhythm sleep disorders (CRSDs) of children with neurodevelopmental disabilities."	2.48	Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities. ( Bax, MC; Ipsiroglu, OS; Jan, JE; Owens, JA; Wasdell, MB, 2012)
"True winter depression (SAD) appears to be rare, although subsyndromal SAD is reported."	2.48	Biological rhythms during residence in polar regions. ( Arendt, J, 2012)
"Search terms were "Alzheimer" "mild cognitive impairment" and "melatonin"."	2.47	The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease. ( Brusco, LI; Cardinali, DP; Furio, AM, 2011)
"Circadian rhythm sleep disorders are common conditions manifested as misalignment between the sleep period and the physical/social 24-h environmental cycle."	2.46	Circadian rhythm sleep disorders. ( Lenz, Mdo C; Martinez, D, 2010)
"Melatonin is a major chronobiological regulator involved in circadian phasing, sleep, and numerous other functions including cyto-/neuroprotection, immune modulation, and energy metabolism."	2.46	Investigational melatonin receptor agonists. ( Hardeland, R, 2010)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."	2.46	Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"Circadian rhythm sleep disorders are poorly understood and often misdiagnosed."	2.46	A circadian rhythm sleep disorder: melatonin resets the biological clock. ( Abbas, A; Milles, J; Raju, J; Ramachandran, S, 2010)
"Circadian rhythm sleep disorders are common in clinical practice."	2.45	A practical approach to circadian rhythm sleep disorders. ( Bjorvatn, B; Pallesen, S, 2009)
"The best-documented approaches to treating circadian rhythm sleep disorders are light and melatonin; physicians can easily administer both treatments."	2.45	[Circadian rhythm sleep disorders]. ( Bjorvatn, B; Pallesen, S, 2009)
"Different types of insomnia symptoms have been associated with abnormalities of the body temperature rhythm."	2.44	The relationship between insomnia and body temperatures. ( Gradisar, M; Lack, LC; Lushington, K; Van Someren, EJ; Wright, HR, 2008)
"Melatonin is a hormone, which is mainly produced by the pineal gland, a vestigial eye."	2.44	Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology. ( Brennan, R; Jan, JE; Lyons, CJ, 2007)
"Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical environment."	2.44	A clinical approach to circadian rhythm sleep disorders. ( Barion, A; Zee, PC, 2007)
"Difficulties with jet lag because of sleep loss and decreased performance are emphasised."	2.44	Jet lag: trends and coping strategies. ( Atkinson, G; Edwards, B; Reilly, T; Waterhouse, J, 2007)
"Melatonin has been shown to correct the underlying circadian rhythm abnormality as well as improve sleep and reduce daytime napping."	2.44	Circadian rhythm sleep disorders in the blind and their treatment with melatonin. ( Arendt, J; Skene, DJ, 2007)
"Patients with advanced sleep phase syndrome are sleepy in the evening and awaken very early and alert in the morning."	2.44	Circadian rhythmicity and the pharmacologic management of insomnia. ( Bramley, TJ; Mitrzyk, BM; Richardson, GS, 2007)
"Circadian rhythm sleep disorders are perhaps the most often overlooked conditions in the differential diagnosis of these symptoms."	2.44	Diagnosis of circadian rhythm sleep disorders. ( Lenz, Mdo C; Martinez, D; Menna-Barreto, L, 2008)
"Melatonin treatment significantly reduced sleep onset latency by 4."	2.43	Effects of exogenous melatonin on sleep: a meta-analysis. ( Ben-Shushan, A; Brzezinski, A; Ford, I; Norrie, G; Vangel, MG; Wurtman, RJ; Zhdanova, I, 2005)
"Individuals who have circadian rhythm sleep disorders present with symptoms of insomnia or excessive sleepiness and complain of an inability to sleep at their desired time."	2.43	Circadian rhythm sleep disorders. ( Burgess, HJ; Reid, KJ, 2005)
"Circadian rhythm sleep disorders, such as jet lag syndrome and shift work sleep disorder, are those specifically attributed to dysfunctions or insufficiencies in the circadian system."	2.43	The human circadian system in normal and disordered sleep. ( Richardson, GS, 2005)
"Melatonin has been successfully used to alleviate jet lag symptoms of travellers and there is also a smaller amount of evidence that the hormone helps shiftworkers adjust to nocturnal regimens."	2.42	The relevance of melatonin to sports medicine and science. ( Atkinson, G; Drust, B; Reilly, T; Waterhouse, J, 2003)
"Melatonin is a hormone produced in human by the pineal body, the endocrine gland localized in the central part of cerebrum."	2.42	[Melatonin and its biological significance]. ( Boguszewska, A; Pasternak, K, 2004)
"Melatonin is a hormone with powerful effects on behavior particularly circadian and sleep behavior."	2.41	Melatonin, sleep, and circadian rhythm disorders. ( Kayumov, L; Shapiro, CM; Zhdanova, IV, 2000)
"Melatonin treatment increased plasma melatonin concentration and restored circadian rhythm."	1.91	Melatonin Treatment of Circadian Rhythm Sleep-Wake Disorder in Obese Children Affects the Brain-Derived Neurotrophic Factor Level. ( Hu, B; Huang, X; Huang, Y, 2023)
"We also characterized mood states, daytime sleepiness, and sleep quality by questionnaires."	1.91	Sleep impairment and altered pattern of circadian biomarkers during a long-term Antarctic summer camp. ( Arantes, RME; Borges, L; Gonçalves, DAP; Hatanaka, E; Heller, D; Marques, AL; Mendes, TT; Moraes, MM; Núñez-Espinosa, C; Soares, DD; Wanner, SP, 2023)
"CRSWD are a distinct class of sleep disorders caused by alterations of the circadian time-keeping system, its entrainment mechanisms, or a misalignment of the endogenous circadian rhythm and the external environment."	1.62	Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities. ( Abbott, SM; Burgess, HJ; Crowley, SJ; Duffy, JF; Emens, JS; Epstein, LJ; Gamble, KL; Hasler, BP; Klerman, EB; Kristo, DA; Malkani, RG; Rahman, SA; Thomas, SJ; Wyatt, JK; Zee, PC, 2021)
"A novel therapy by total sleep deprivation followed by a combination of morning light therapy and nocturnal melatonin administration was efficient in stopping his free-running sleep-wake pattern both immediately and in the long term."	1.62	Sleep deprivation therapy to reset the circadian pacemaker in a non-24-hour sleep-wake disorder: a case report. ( Guichard, K; Micoulaud-Franchi, JA; Philip, P; Taillard, J, 2021)
"Insomnia and circadian rhythm sleep disorders affect large proportions of the population and have pronounced effects on quality of life and daytime performance."	1.51	Clinical Sleep-Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders. ( Nissen, C; Riemann, D; Spiegelhalder, K, 2019)
"Subjective and objective sleepiness and sleep-related and hazardous driving events significantly increased following night shift compared with preshift."	1.51	Sleepiness and driving events in shift workers: the impact of circadian and homeostatic factors. ( Anderson, C; Collins, A; Ganesan, S; Howard, ME; Lockley, SW; Magee, M; Mulhall, MD; Rajaratnam, SMW; Sletten, TL; Stone, JE, 2019)
"The present results suggest that sleep fragmentation and any resultant cognitive deficits are likely not confounded by corresponding deficits in circadian rhythms."	1.46	Young children with Down syndrome show normal development of circadian rhythms, but poor sleep efficiency: a cross-sectional study across the first 60 months of life. ( Anand, P; Clark, C; Demara, BI; Edgin, JO; Fernandez, F; Nyhuis, CC; Ruby, NF; Spanò, G, 2017)
"Treatment with melatonin up to 14 mg at bedtime was initiated with complete realignment of the sleep-wake rhythm (tau 23."	1.46	Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst. ( Antelmi, E; Ferri, L; Filardi, M; Moresco, M; Pierangeli, G; Pizza, F; Plazzi, G; Toni, F; Vandi, S; Zucchelli, M, 2017)
"Patients with insomnia and healthy control participants completed a sleep log for 7 days."	1.46	Circadian Phase and Phase Angle Disorders in Primary Insomnia. ( Bremer, E; Brogna, LA; Burke, LM; Epstein, LJ; Flynn-Evans, EE; Gehrman, P; Kirsch, D; Lockley, SW; Miller, B; Murray, JM; Rajaratnam, SMW; Shekleton, JA, 2017)
"Melatonin levels were significantly suppressed by white light only."	1.43	Light at Night and Measures of Alertness and Performance: Implications for Shift Workers. ( Figueiro, MG; Plitnick, B; Sahin, L; Wood, B, 2016)
"Williams-Beuren syndrome (WBS), a neurodevelopmental disorder caused by a microdeletion on chromosomic region 7q11."	1.43	Correlations between behavior, memory, sleep-wake and melatonin in Williams-Beuren syndrome. ( Campos, LM; Giacheti, CM; Pinato, L; Rossi, NF; Santoro, SD, 2016)
"To characterize and compare insomnia symptoms within two common phenotypes of Shift Work Disorder."	1.42	Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder. ( Belcher, R; Drake, CL; Gumenyuk, V; Roth, T, 2015)
"Among shift work disorder patients, insomnia is linked to functional and cognitive impairments."	1.42	Insomnia in shift work disorder relates to occupational and neurophysiological impairment. ( Belcher, R; Gumenyuk, V; Roth, T, 2015)
"The melatonin level was higher in the morning for both day shifts (p = 0."	1.42	Sleep interruption associated with house staff work schedules alters circadian gene expression. ( Crabtree, BF; Fang, MZ; Kelly-McNeil, K; Kipen, H; Lew, JP; Ohman-Strickland, P; Zarbl, H, 2015)
"Finally, acute sleep deprivation impaired behavioral performance and the P3a ERP in both groups."	1.40	Sleep loss, circadian mismatch, and abnormalities in reorienting of attention in night workers with shift work disorder. ( Drake, CL; Gumenyuk, V; Howard, R; Korzyukov, O; Roth, T, 2014)
"Melatonin is a hormone with well-known chronobiotic and hypnotic effects."	1.40	Chronobiology, cognitive function and depressive symptoms in surgical patients. ( Hansen, MV, 2014)
"Treatment with melatonin prevented premature aging and tumorigenesis in rodents."	1.38	Light-at-night-induced circadian disruption, cancer and aging. ( Anisimov, VN; Panchenko, AV; Popovich, IG; Vinogradova, IA; Zabezhinski, MA, 2012)
"Melatonin concentration was measured with a radioimmunoassay and DLMO was defined as the time at which the melatonin concentration in saliva reaches 4 pg/mL."	1.37	Evaluation of salivary melatonin measurements for Dim Light Melatonin Onset calculations in patients with possible sleep-wake rhythm disorders. ( Endenburg, SC; Gunnewiek, JM; Keijzer, H; Looman, CW; Peeters, T; Smits, MG, 2011)
"Before treatment, the patient had mild hypersomnia with long sleep time (704 min), ultradian sleep-wake rhythm (sleep occurred every 11."	1.36	Sleep and rhythm consequences of a genetically induced loss of serotonin. ( Arnulf, I; Boniol, C; Clot, F; Decaix, C; Leu-Semenescu, S; Levy, R; Moussa, F; Roze, E; Touitou, Y; Vidailhet, M, 2010)
"Disturbed sleep and/or hypersomnia are direct consequences of shift work and therefore described as shift work disorder."	1.36	[Burden and health effects of shift work]. ( Heitmann, J, 2010)
"Tasimelteon has been claimed to be useful in the treatment of depression, and preclinical evidence in this respect is to be confirmed in a phase II clinical trial, which was ready to be initiated at the time of publication."	1.35	Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. ( Hardeland, R, 2009)
"Treatment with melatonin (5 mg, 2 h before bedtime) did not improve his condition."	1.33	Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder? ( Dagan, Y; Doljansky, JT; Kannety, H, 2005)
"Melatonin and GH were measured every 10 min over 24 h."	1.32	The 24-h growth hormone rhythm in men: sleep and circadian influences questioned. ( Brandenberger, G; Weibel, L, 2004)
"Melatonin suppression was not significantly different with upper or middle field illumination."	1.31	Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteers. ( Elliott, JA; Kripke, DF; Smith, JS; Youngstedt, SD, 2002)
"Melatonin treatment improved all scales except the scale "role due to emotional problems."	1.31	Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. ( Coenen, AM; Kerkhof, GA; Laurant, MW; Nagtegaal, JE; Smits, MG; van der Meer, YG, 2000)
"Melatonin treatment increased nighttime sleep from 5."	1.31	Melatonin improves sleep-wake patterns in psychomotor retarded children. ( Etzioni, A; Lavie, P; Peled, N; Pillar, G; Ravid, S; Shahar, E, 2000)
"Melatonin is a well-tolerated, safe, relatively inexpensive, and effective drug, with minimal side effects, for the treatment of severe circadian rhythm sleep disorder in handicapped children."	1.31	Melatonin for the treatment of handicapped children with severe sleep disorders. ( Jan, MM, 2000)
"Melatonin (3 mg) was commenced following chronotherapy and this improved their sleep-wake rhythm."	1.31	Therapeutic progress of two sibling cases exhibiting sleep-wake rhythm disorder. ( Maeda, H; Mukai, M; Sakamoto, T; Takaishi, J; Takeuchi, N; Uchimura, N; Waseda, Y, 2000)
"The subjects were 46 patients with circadian rhythm sleep disorders: 30 Delayed Sleep Phase Syndrome (DSPS) and 16 non-24 h sleep-wake syndrome (non-24)."	1.31	Melatonin treatment for circadian rhythm sleep disorders. ( Hayakawa, T; Kamei, Y; Kim, K; Kudo, Y; Okawa, M; Shibui, K; Uchiyama, M; Urata, J, 2000)
"Advanced sleep phase syndrome is characterized by the complaint of persistent early evening sleep onset and early morning awakening."	1.31	Familial advanced sleep phase syndrome. ( Chang, AM; Dubocovich, ML; Reid, KJ; Takahashi, JS; Turek, FW; Zee, PC, 2001)
"Seventy-two elders with complaints of insomnia or depression, and 30 young, healthy adults were assessed for 5-7 days at home."	1.31	Circadian abnormalities in older adults. ( Elliott, JA; Klauber, MR; Kripke, DF; Youngstedt, SD, 2001)
"Melatonin is an indole hormone that is produced by the pineal gland, mainly at night, with a peak around 3."	1.31	[Melatonin and circadian rhythm]. ( Borson-Chazot, F; Brun, J; Claustrat, B, 2001)
"Melatonin is a promising treatment alternative for serious sleep problems in blind children."	1.31	[Melatonin treatment of a blind child with serious sleep disorders]. ( Loge, JH; Ramstad, K, 2002)

Research

Studies (358)

Authors

Clinical Trials (32)

Trial Overview

Trial Outcomes

Dim Light Melatonin Onset and Offset

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (0.84)	18.2507
2000's	147 (41.06)	29.6817
2010's	150 (41.90)	24.3611
2020's	58 (16.20)	2.80

Authors	Studies
Sun, SY	1
Chen, GH	1
Gibson, M	1
Boivin, DB	5
Boudreau, P	2
Kosmadopoulos, A	1
Qian, J	1
Morris, CJ	1
Phillips, AJK	5
Li, P	1
Rahman, SA	6
Wang, W	3
Hu, K	2
Arendt, J	9
Czeisler, CA	14
Scheer, FAJL	2
Duffy, JF	9
Ronda, JM	2
Wang, J	2
Di, H	1
Kim, JH	2
Elkhadem, AR	1
Cyr, M	1
Artenie, DZ	1
Al Bikaii, A	1
Borsook, D	1
Olson, JA	1
Sun, Y	1
Feng, W	1
Chen, J	1
Liu, M	1
Shi, X	1
Zou, L	1
Xu, T	1
Yang, G	1
Shimura, A	1
Kanno, T	1
Inoue, T	1
Carriedo-Diez, B	1
Tosoratto-Venturi, JL	1
Cantón-Manzano, C	1
Wanden-Berghe, C	1
Sanz-Valero, J	1
Meyer, N	1
Harvey, AG	1
Lockley, SW	16
Dijk, DJ	11
Burgess, HJ	14
Emens, JS	7
van Andel, E	2
Bijlenga, D	3
Vogel, SWN	2
Beekman, ATF	2
Kooij, JJS	2
Hartstein, LE	3
Diniz Behn, C	4
Wright, KP	6
Akacem, LD	3
Stowe, SR	3
LeBourgeois, MK	3
Glacet, R	2
Reynaud, E	2
Robin-Choteau, L	2
Reix, N	2
Hugueny, L	2
Ruppert, E	2
Geoffroy, PA	3
Kilic-Huck, Ü	3
Comtet, H	2
Bourgin, P	2
Huang, X	2
Huang, Y	1
Hu, B	1
Tuft, C	1
Matar, E	1
Menczel Schrire, Z	1
Grunstein, RR	5
Yee, BJ	1
Hoyos, CM	1
Swanson, LM	1
Raglan, GB	1
Bazin, B	1
Benzaquen, H	1
Maruani, J	1
Romier, A	1
Lejoyeux, M	1
D'ortho, MP	1
Frija-Masson, J	1
Hida, A	2
Iida, A	1
Ukai, M	1
Kadotani, H	1
Uchiyama, M	6
Ebisawa, T	2
Inoue, Y	4
Kitamura, S	2
Mishima, K	4
Pundir, M	2
De Rosa, MC	1
Lobanova, L	2
Abdulmawjood, S	1
Chen, X	3
Papagerakis, S	2
Papagerakis, P	2
Atan, YS	1
Subaşı, M	1
Güzel Özdemir, P	1
Batur, M	1
Ziegler, KA	1
Ahles, A	1
Dueck, A	1
Esfandyari, D	1
Pichler, P	1
Weber, K	1
Kotschi, S	1
Bartelt, A	1
Sinicina, I	1
Graw, M	1
Leonhardt, H	1
Weckbach, LT	1
Massberg, S	1
Schifferer, M	1
Simons, M	1
Hoeher, L	1
Luo, J	1
Ertürk, A	1
Schiattarella, GG	1
Sassi, Y	1
Misgeld, T	1
Engelhardt, S	1
Davis, H	1
Attwell, D	1
Lack, LC	7
Micic, G	5
Lovato, N	7
Moraes, MM	1
Marques, AL	1
Borges, L	1
Hatanaka, E	1
Heller, D	1
Núñez-Espinosa, C	1
Gonçalves, DAP	1
Soares, DD	1
Wanner, SP	1
Mendes, TT	1
Arantes, RME	1
Typaldos, M	1
Sockrider, M	1
Moderie, C	3
Van der Maren, S	3
Paquet, J	2
Dumont, M	4
Mocayar Marón, FJ	1
Ferder, L	1
Reiter, RJ	3
Manucha, W	1
Reutrakul, S	1
Crowley, SJ	6
Park, JC	1
Chau, FY	1
Priyadarshini, M	1
Hanlon, EC	1
Danielson, KK	1
Gerber, BS	1
Baynard, T	1
Yeh, JJ	1
McAnany, JJ	1
Butler, MP	1
Thosar, SS	1
Smales, C	1
DeYoung, PN	1
Wu, H	1
Hussain, MV	1
Morimoto, M	1
Shea, SA	2
Watson, LA	2
McGlashan, EM	2
Hosken, IT	2
Anderson, C	3
Cain, SW	2
Sciarra, F	1
Franceschini, E	1
Campolo, F	1
Gianfrilli, D	1
Pallotti, F	1
Paoli, D	1
Isidori, AM	1
Venneri, MA	1
Coles, ME	1
Schubert, J	1
Stewart, E	1
Sharkey, KM	6
Deak, M	1
Ferguson, SA	3
Lack, L	5
Ballester, P	1
Richdale, AL	1
Baker, EK	1
Peiró, AM	1
Kimura, S	1
Toyoura, M	1
Toyota, Y	1
Takaoka, Y	1
El-Benhawy, SA	1
El-Tahan, RA	1
Nakhla, SF	1
Sholtes, D	1
Kravitz, HM	1
Deka, A	1
Westrick, J	1
Fogg, LF	6
Gottlieb, M	1
Feder, MA	1
Baroni, A	2
Wang, F	2
Xie, N	1
Wu, Y	1
Zhang, Q	1
Zhu, Y	2
Dai, M	1
Zhou, J	1
Pan, J	1
Tang, M	1
Cheng, Q	1
Shi, B	1
Guo, Q	1
Li, X	1
Xie, L	1
Wang, B	1
Yang, D	1
Weng, Q	1
Guo, L	1
Ye, J	1
Pan, M	1
Zhang, S	1
Zhou, H	1
Zhen, C	1
Liu, P	1
Ning, K	1
Brackenridge, L	1
Hardiman, PJ	1
Qu, F	1
da Silveira Cruz-Machado, S	1
Guissoni Campos, LM	1
Fadini, CC	1
Anderson, G	1
Markus, RP	1
Pinato, L	2
Quera-Salva, MA	3
Vecchierini, MF	1
Abbott, SM	2
Epstein, LJ	2
Gamble, KL	2
Hasler, BP	4
Kristo, DA	1
Malkani, RG	1
Thomas, SJ	1
Wyatt, JK	7
Zee, PC	14
Klerman, EB	3
Martin, JS	1
Laberge, L	1
Sasseville, A	1
Bérubé, M	1
Alain, S	1
Lavoie, J	1
Houle, J	1
Hébert, M	1
Nishimon, S	1
Nishino, N	1
Nishino, S	2
Guichard, K	1
Micoulaud-Franchi, JA	1
Philip, P	1
Taillard, J	1
Uddin, MS	1
Sumsuzzman, DM	1
Jeandet, P	1
Behl, T	1
Rauf, A	1
Amran, MS	1
Ashraf, GM	1
Cheng, DCY	1
Ganner, JL	1
Gordon, CJ	1
Phillips, CL	1
Comas, M	1
Zhao, S	1
Hou, J	1
Huang, L	1
Xu, J	1
He, M	1
Shen, O	1
Zhang, J	1
Gehrman, PR	1
Anafi, RC	1
Grant, LK	1
St Hilaire, MA	3
Brainard, GC	2
Cogswell, D	1
Bisesi, P	1
Markwald, RR	1
Cruickshank-Quinn, C	1
Quinn, K	1
McHill, A	1
Melanson, EL	1
Reisdorph, N	1
Depner, CM	1
Brotman, DJ	1
Lin, AL	1
Lewy, AJ	4
Saeed, Y	1
Murray, JM	3
Sletten, TL	6
Magee, M	5
Gordon, C	2
Bartlett, DJ	3
Kennaway, DJ	5
Rajaratnam, SM	3
Fernandez, F	1
Nyhuis, CC	1
Anand, P	1
Demara, BI	1
Ruby, NF	1
Spanò, G	1
Clark, C	1
Edgin, JO	1
Clerx, WM	1
O'Brien, CS	1
Sano, A	1
Barger, LK	1
Picard, RW	1
Hunter, CM	1
Figueiro, MG	5
Ftouni, S	2
Nicholas, CL	2
Ferguson, S	2
O'Brien, D	1
Rajaratnam, SMW	6
Auld, F	1
Maschauer, EL	1
Morrison, I	1
Skene, DJ	6
Riha, RL	2
Spiegelhalder, K	1
Nissen, C	1
Riemann, D	2
Burman, D	1
Ferri, L	1
Filardi, M	1
Moresco, M	1
Pizza, F	1
Vandi, S	1
Antelmi, E	1
Toni, F	1
Zucchelli, M	1
Pierangeli, G	1
Plazzi, G	1
Flynn-Evans, EE	1
Shekleton, JA	1
Miller, B	1
Kirsch, D	1
Brogna, LA	1
Burke, LM	1
Bremer, E	1
Gehrman, P	1
Solaiman, SS	1
Agrawal, R	1
Duclos, C	1
Daneault, V	1
Keijzer, H	3
Snitselaar, MA	1
Smits, MG	7
Spruyt, K	1
Ehrhart, F	1
Curfs, LM	2
Hartley, S	1
Dauvilliers, Y	1
Ba-Ali, S	1
Brøndsted, AE	1
Andersen, HU	1
Sander, B	1
Jennum, PJ	1
Lund-Andersen, H	1
Resuehr, D	1
Wu, G	1
Johnson, RL	1
Young, ME	1
Hogenesch, JB	1
Ghaziuddin, N	1
Shamseddeen, W	1
Bertram, H	1
McInnis, M	1
Wilcox, HC	1
Mitchell, PB	1
Fullerton, JM	1
Roberts, GMP	1
Glowinski, AL	1
Kamali, M	1
Stapp, E	1
Hulvershorn, LA	1
Nurnberger, J	1
Armitage, R	1
Ganesan, S	2
Stone, JE	2
Mulhall, MD	2
Collins, A	2
Howard, ME	2
Simon, SL	1
McWhirter, L	1
Bubar, KM	1
Kaar, JL	1
Pyle, L	1
Rahat, H	1
Garcia-Reyes, Y	1
Carreau, AM	1
Nadeau, KJ	1
Cree-Green, M	1
Haraguchi, A	1
Komada, Y	2
Shibata, S	2
Kuppili, PP	1
Nebhinani, N	1
Gupta, T	1
Suthar, N	1
Bei, B	1
Culnan, E	1
McCullough, LM	1
Russcher, M	3
Koch, BC	4
Nagtegaal, JE	5
van Ittersum, FJ	1
Pasker-de Jong, PC	1
Hagen, EC	2
van Dorp, WT	1
Gabreëls, B	1
Wildbergh, TX	1
van der Westerlaken, MM	3
Gaillard, CA	3
Ter Wee, PM	3
White, RD	1
Khan, SA	1
George, R	1
Charles, BG	1
Taylor, PJ	1
Heussler, HS	1
Cooper, DM	1
McGuire, TM	1
Pache, D	2
Norris, RL	1
Montagnese, S	1
De Pittà, C	1
De Rui, M	1
Corrias, M	1
Turco, M	1
Merkel, C	1
Amodio, P	1
Costa, R	1
Gatta, A	1
Shapiro, CM	4
Ainlay, H	1
Kazmi, S	1
Brown, TJ	1
Casper, RF	3
de Bruyn, A	1
Wright, H	2
Gradisar, M	4
Kovacic, P	1
Somanathan, R	1
Van Someren, EJ	6
Gruber, R	1
Bron, TI	1
Kruithof, IF	1
Spanbroek, EC	1
Kooij, JJ	1
Rondanelli, M	1
Faliva, MA	1
Perna, S	1
Antoniello, N	1
Wilhelmsen-Langeland, A	2
Saxvig, IW	2
Pallesen, S	4
Nordhus, IH	2
Vedaa, Ø	1
Lundervold, AJ	1
Bjorvatn, B	6
Biggs, SN	1
Armstrong, SM	1
van de Werken, M	2
Booij, SH	1
van der Zwan, JE	1
Simons, MJ	1
Gordijn, MC	2
Beersma, DG	2
Morrissette, DA	1
O'Neill, B	1
Gardani, M	1
Findlay, G	1
Whyte, T	1
Cullen, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Sleep Length and Euploid Embryo Transfer Prospective Study[NCT06139757]		150 participants (Anticipated)	Observational	2024-01-01	Not yet recruiting
Prevalence of Epilepsy and Sleep Wake Disorders in Alzheimer Disease[NCT03617497]		78 participants (Actual)	Interventional	2020-12-01	Active, not recruiting
Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)[NCT05965609]		60 participants (Anticipated)	Interventional	2023-12-08	Recruiting
Assessment of Hepatic Glucose and Fat Regulation in Overweight Adolescent Girls[NCT02157974]	Phase 2/Phase 3	92 participants (Actual)	Interventional	2014-08-31	Completed
Investigating the Relationship Between Circadian Phase and Insulin Resistance in Obese Adolescents[NCT02585830]		25 participants (Actual)	Observational	2015-10-31	Completed
Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment[NCT00834886]	Phase 4	40 participants (Actual)	Interventional	2008-10-31	Completed
Role of Endogenous Melatonin Level in Preoperative and Postoperative Anxiety in Bariatric Surgery Patients[NCT03109054]		50 participants (Anticipated)	Observational	2017-03-15	Enrolling by invitation
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599]	Phase 2	86 participants (Actual)	Interventional	2016-07-31	Completed
Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.[NCT03107702]		35 participants (Anticipated)	Observational	2017-03-29	Enrolling by invitation
[NCT01487252]		73 participants (Actual)	Interventional	2011-12-31	Completed
Circadian Misalignment as a Disease Risk Factor in Inflammatory Bowel Disease[NCT04637399]		52 participants (Actual)	Observational	2016-11-22	Completed
Sleep Thermography for Diagnosis of Obstructive Sleep Apnea (OSA)[NCT04206449]		198 participants (Actual)	Interventional	2018-09-10	Completed
Regulating Mood and Suicidal Ideation With Morning Light Exposure Treatment[NCT05616819]		480 participants (Anticipated)	Interventional	2023-03-01	Not yet recruiting
Effects of Procedure Started in the Morning and Afternoon on Early Postoperative Sleep Function and Postoperative Recovery in Patients Under General Anesthesia[NCT04103528]		62 participants (Actual)	Interventional	2018-10-09	Completed
The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms[NCT03758768]		34 participants (Actual)	Interventional	2018-09-25	Completed
Does CBT Improve the Effect of Light Therapy in Delayed Sleep Phase Syndrome Compared to Only Light Therapy - Short and Long Term Follow up[NCT01419938]		57 participants (Actual)	Interventional	2011-08-31	Completed
The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients[NCT00404456]	Phase 3	40 participants (Anticipated)	Interventional	2005-04-30	Completed
A Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Agomelatine in the Prevention of Poststroke Depression[NCT05426304]	Phase 4	420 participants (Anticipated)	Interventional	2022-10-01	Not yet recruiting
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172]	Phase 2	60 participants (Actual)	Interventional	2014-12-31	Completed
Prevention of Delirium in Inpatients Utilizing Melatonin[NCT02654314]	Phase 3	277 participants (Actual)	Interventional	2016-07-31	Terminated (stopped due to Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.)
Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950]		104 participants (Anticipated)	Interventional	2017-06-26	Recruiting
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia[NCT03075657]	Phase 4	120 participants (Actual)	Interventional	2017-05-01	Completed
Effects of Shift Work on Health: Assessment of Sleep Quality, Motor Control and Cardiovascular Risk.[NCT03453398]		71 participants (Actual)	Interventional	2018-01-23	Completed
Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309]	Phase 3	25 participants (Actual)	Interventional	2016-07-31	Completed
Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation[NCT04547439]	Phase 2	36 participants (Anticipated)	Interventional	2021-02-03	Recruiting
Effects of Bright Light Treatment on Daytime Sleepiness and Nocturnal Sleep in Patients With Parkinson's Disease[NCT01338649]		27 participants (Actual)	Interventional	2007-11-30	Completed
Restoration of Sleep in Heart Failure Patients[NCT00869869]	Phase 2	0 participants (Actual)	Interventional	2009-03-31	Withdrawn (stopped due to No subjects were enrolled in this study. Funding ran out.)
Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars[NCT01169233]		25 participants (Actual)	Interventional	2008-08-31	Completed
A Placebo-controlled, Double -Blind Randomised Trial of Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence[NCT03897062]	Phase 2	22 participants (Actual)	Interventional	2019-08-26	Terminated (stopped due to Recruitment problems during covid lockdowns resulted in Merck ceasing supply of suvorexant/placebo)
Characterization of Endogenous Melatonin Profiles in Children With Autism Spectrum Disorder.[NCT00691080]		58 participants (Actual)	Observational	2007-09-30	Completed
Melatonin Entrainment of Elderly Blind Free-runners[NCT00692094]		12 participants (Actual)	Interventional	2004-08-31	Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.)
Effects of Blocking Blue Light at Night on Patient Outcomes After Elective CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH[NCT04578249]		80 participants (Anticipated)	Interventional	2021-09-20	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

~1mL saliva was collected at 30- to 60- minute intervals in dim light (<5 lux in the angle of gaze, approximately the light level of candlelight or civil twilight) from approximately 5pm until noon the next day. Dim light melatonin onset (DLMOn) was defined as the linear interpolated clock time at which evening salivary melatonin concentrations increased and remained above a threshold of 3pg/mL. Melatonin offset (DLMOff) was the linear interpolated clock time at which salivary melatonin concentrations fell below this threshold. Later DLMOn and DLMOff are indicative of a later circadian rhythm. (NCT02585830)
Timeframe: 1 day

Insulin Sensitivity

Intervention	decimal hours (Mean)
	Dim Light Melatonin Onset	Dim Light Melatonin Offset
Observation	21.33	8.32

After an overnight fast, participants completed an oral glucose tolerance test (OGTT) in the morning. Participants consumed a 75g dextrose drink and serum for glucose and insulin concentrations were collected at baseline and every 30 minutes for 3 hours. The homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as [fasting insulin (μU/ml) x fasting glucose (mmol/l)] / 22.5); lower HOMA-IR indicates better insulin sensitivity. The Matsuda Index was calculated as √10,000 / [[fasting insulin (μU/ml) x fasting glucose (mmol/l)] x [mean OSTT insulin (μU/ml) x mean OSTT glucose (mmol/l)]]; high Matsuda Index indicates better insulin sensitivity. (NCT02585830)
Timeframe: 3 hours

To Investigate the Efficacy on Rise Time of Bright Light Therapy and Melatonin Treatment Using a 4 Armed Placebo Controlled Design. Main Outcome Measures: Sleep Log, Actigraphy and Psychological Tests.

Intervention	units on a scale (Mean)
	Homeostatic Model Assessment (HOMA-IR)	Matsuda Index
Observation	2.9	4.93

"Sleep diary, rise time (when participants rise from bed in the morning, self-report) before and after a randomized controlled 4 armed treatment study including a follow-up 3 months later.~Midnight is 0000; in the outcome measure table the value is given in minutes after midnight.~i.e. 530 equals 08:50 in the morning." (NCT00834886)
Timeframe: 1 day after two-week treatment ends

To Investigate the Efficacy on Sleep Onsel Latency of Bright Light Therapy and Melatonin Treatment Using a 4 Armed Placebo Controlled Design. Main Outcome Measures: Sleep Log, Actigraphy and Psychological Tests.

Intervention	Minutes (Mean)
Combination	530
Melatonin	506
Bright Light	520
Placebo	543

Actigraphy, sleep onset latency (SOL). An actigraph is a wrist-worn movement sensor that objectively record motor activity. Participants used an event button to mark bed time and rise time. The actiwatch is waterproof and participants were instructed not to take it off at any time during the data collection peroid. (NCT00834886)
Timeframe: 1 day after 2-week treatment ended

To Investigate the Efficacy on Subjective Sleepiness of Bright Light Therapy and Melatonin Treatment Using a 4 Armed Placebo Controlled Design. Main Outcome Measures: Sleep Log, Actigraphy and Psychological Tests.

Intervention	Minutes (Mean)
Combination	11
Melatonin	21
Bright Light	15
Placebo	24

"Subjective sleepiness; Karolinska sleepiness scale (KSS). The KSS is a scale in which the subjects rate their concurrent sleepiness level. The scale is verbally anchored with steps ranging from 1 (very alert) to 9 (very sleepy, fighting sleep, effort to stay awake)." (NCT00834886)
Timeframe: 1 day after 2-week treatment ended

Postoperative Hospital Stay

Intervention	units on a scale (Mean)
Combination	6.0
Melatonin	5.9
Bright Light	6.3
Placebo	6.5

Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days

Changes in C-reactive Protein (CRP) Levels

Intervention	days (Median)
Morphine	7
Levobupivacaine	7

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Cognitive Function

Intervention	mg/L (Median)
	Before surgery	24 h after surgery	72 h after surgery	120 h after surgery
Levobupivacaine	57.8	98.1	95	54.6
Morphine	57.2	106.2	118.5	66.9

"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery

Changes in Fibrinogen Concentrations in Peripheral Blood

Intervention	score on a scale (Median)
	Before surgery	24 h after surgery	48 h after surgery	72 h after surgery	96 h after surgery	120 h after surgery
Levobupivacaine	22	22	21	21	21	22
Morphine	21	20	20	20	20	20

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Pain Intensity

Intervention	g/L (Median)
	Before surgery	24 h after surgery	72 h after surgery	120 h after surgery
Levobupivacaine	4.5	4.7	5.2	5
Morphine	5.5	5.3	5.7	5.4

"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge

Interleukin-6 Concentration in Peripheral Blood.

Intervention	score on a scale (Median)
	3,6,9,12,15,18,21 and 24h after surgery	27,30,33,36,39,42,45 and 48h after surgery	51,54,57,60,63,66,69 and 72h after surgery	4. postoperative day (every 8 hours)	5. postoperative day (every 8 hours)	6. postoperative day (every 8 hours)	Day of discharge
Levobupivacaine	0.6	0.5	0.5	0.3	0	0	0
Morphine	1.4	1.5	1.4	1.4	1.4	1.3	1

Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery

Days Utilizing Restraints

Intervention	pg/ml (Median)
	Before surgery	24h after surgery	72h after surgery
Levobupivacaine	26.6	97.7	30.5
Morphine	27.2	104	50

Days utilizing restraints is defined as the number of days restraints were applied because of delirium in the first 14 days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Delirium

Intervention	days (Median)
Melatonin	0
Cellulose Microcrystylline	0

Delirium is defined by the Short Form Confusion Assessment Method (CAM). There must be inattention and either an acute or fluctuating course plus either disorganized thinking or an altered level of consciousness to be diagnosed with delirium. Presented is a count of individuals with reported delirium during hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Length of Hospital Stay

Intervention	Participants (Count of Participants)
Melatonin	2
Cellulose Microcrystylline	8

Length of stay is defined as the total time hospitalized for the acute illness (in days). (NCT02654314)
Timeframe: from day of admission to completion of acute care, not to exceed 30 days

Number of Delirium Anti-psychotic Drug Doses Utilized for Delirium During the First 14 Days of Hospitalization.

Intervention	days (Mean)
Melatonin	4.58
Cellulose Microcrystylline	4.71

Number of delirium anti-psychotic drug doses given for symptoms of delirium. Presented are the number of doses per days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Change in the Epworth Sleepiness Scale (ESS) Scores Comparing the Bright Light Exposure With Dim-red Light Exposure.

Intervention	number of doses per days of hospitalizat (Median)
Melatonin	0
Cellulose Microcrystylline	0

ESS score range is 0-24; lower ESS scores indicate less daytime sleepiness; higher ESS scores indicate more severe sleepiness ESS will be taken and compared at screening and week 4 visits between the bright light exposure and dim-red light exposure groups. (NCT01338649)
Timeframe: baseline and 4 weeks

Intervention	score (Mean)
Bright White	4.46
Dim Red Light	1.77

Article	Year
Treatment of Circadian Rhythm Sleep-Wake Disorders. Current neuropharmacology, 2022, Volume: 20, Issue:6 Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiation and	2022
A systematic review of the relationship between night shift work and oxidative stress. Chronobiology international, 2022, Volume: 39, Issue:2 Topics: Circadian Rhythm; Humans; Melatonin; Oxidative Stress; Reactive Oxygen Species; Shift Work Schedule;	2022
Disturbance of the Circadian System in Shift Work and Its Health Impact. Journal of biological rhythms, 2022, Volume: 37, Issue:1 Topics: Circadian Rhythm; Humans; Leukocytes, Mononuclear; Melatonin; Shift Work Schedule; Sleep; Sleep Diso	2022
Circadian Rhythm Sleep-Wake Disorders in Older Adults. Sleep medicine clinics, 2022, Volume: 17, Issue:2 Topics: Aged; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Diso	2022
The effect of evening light on circadian-related outcomes: A systematic review. Sleep medicine reviews, 2022, Volume: 64 Topics: Circadian Rhythm; Humans; Light; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Work Schedule	2022
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. International journal of environmental research and public health, 2022, 08-17, Volume: 19, Issue:16 Topics: Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Sleep; Sleep Disorder	2022
Circadian rhythms and disorders of the timing of sleep. Lancet (London, England), 2022, 09-24, Volume: 400, Issue:10357 Topics: Biological Factors; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; S	2022
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances. Sleep medicine clinics, 2022, Volume: 17, Issue:3 Topics: Circadian Rhythm; Humans; Melatonin; Receptors, Melatonin; Sleep; Sleep Disorders, Circadian Rhythm	2022
Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Clinical interventions in aging, 2023, Volume: 18 Topics: Aged; Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Sleep; Sleep Disorders, Circadia	2023
Circadian Interventions as Adjunctive Therapies to Cognitive-Behavioral Therapy for Insomnia. Sleep medicine clinics, 2023, Volume: 18, Issue:1 Topics: Circadian Rhythm; Cognitive Behavioral Therapy; Humans; Melatonin; Sleep; Sleep Disorders, Circadian	2023
Circadian aspects in the aetiology and pathophysiology of insomnia. Journal of sleep research, 2023, Volume: 32, Issue:6 Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiation and	2023
Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin. The Journal of steroid biochemistry and molecular biology, 2020, Volume: 199 Topics: Animals; Apoptosis; Humans; Melatonin; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Reni	2020
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances. Sleep medicine clinics, 2020, Volume: 15, Issue:2 Topics: Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Sleep; Sleep Disorders, Circadian Rhyt	2020
Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility. International journal of molecular sciences, 2020, May-30, Volume: 21, Issue:11 Topics: Androgens; Animals; Body Temperature; Circadian Clocks; Circadian Rhythm; Estrogens; Female; Glucoco	2020
Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review. Journal of biological rhythms, 2020, Volume: 35, Issue:5 Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm	2020
Sleep in autism: A biomolecular approach to aetiology and treatment. Sleep medicine reviews, 2020, Volume: 54 Topics: Autistic Disorder; Brain; Central Nervous System Depressants; Comorbidity; gamma-Aminobutyric Acid;	2020
Optimising sleep and performance during night float: A systematic review of evidence and implications for graduate medical education trainees. Journal of sleep research, 2021, Volume: 30, Issue:4 Topics: Adaptation, Physiological; Attention; Caffeine; Education, Medical, Graduate; Energy Drinks; Fatigue	2021
Just Let Me Sleep in: Identifying and Treating Delayed Sleep Phase Disorder in Adolescents. Child and adolescent psychiatric clinics of North America, 2021, Volume: 30, Issue:1 Topics: Adolescent; Humans; Melatonin; Prevalence; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiatio	2021
Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease. Neurochemical research, 2021, Volume: 46, Issue:7 Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Circadian Rhythm; Gastrointestin	2021
The efficacy of combined bright light and melatonin therapies on sleep and circadian outcomes: A systematic review. Sleep medicine reviews, 2021, Volume: 58 Topics: Aged; Circadian Rhythm; Humans; Light; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wa	2021
Circadian Disruption Associated with Alzheimer's Disease. Current neurology and neuroscience reports, 2017, Volume: 17, Issue:4 Topics: Alzheimer Disease; Amyloidogenic Proteins; Animals; Circadian Rhythm; Humans; Melatonin; Phototherap	2017
Measuring Light at Night and Melatonin Levels in Shift Workers: A Review of the Literature. Biological research for nursing, 2017, Volume: 19, Issue:4 Topics: Adult; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Middle Aged; Neoplasms; Photoperiod	2017
Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep medicine reviews, 2017, Volume: 34 Topics: Humans; Melatonin; Randomized Controlled Trials as Topic; Sleep Disorders, Circadian Rhythm; Sleep W	2017
Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. FP essentials, 2017, Volume: 460 Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Hygiene; Wakefu	2017
Circadian Rhythm Sleep-Wake Disorders in Older Adults. Sleep medicine clinics, 2018, Volume: 13, Issue:1 Topics: Aged; Central Nervous System Depressants; Circadian Clocks; Circadian Rhythm; Humans; Jet Lag Syndro	2018
Precision medicine in circadian rhythm sleep-wake disorders: current state and future perspectives. Personalized medicine, 2017, Volume: 14, Issue:2 Topics: Circadian Rhythm; Humans; Melatonin; Polysomnography; Precision Medicine; Sleep; Sleep Disorders, Ci	2017
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances. Sleep medicine clinics, 2018, Volume: 13, Issue:2 Topics: Humans; Hypnotics and Sedatives; Melatonin; Receptors, Melatonin; Sleep Disorders, Circadian Rhythm	2018
Circadian Rhythm Disturbances in the Blind. Current neurology and neuroscience reports, 2018, 08-06, Volume: 18, Issue:10 Topics: Blindness; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake	2018
The use and misuse of exogenous melatonin in the treatment of sleep disorders. Current opinion in pulmonary medicine, 2018, Volume: 24, Issue:6 Topics: Central Nervous System Depressants; Humans; Melatonin; Parasomnias; Sleep; Sleep Disorders, Circadia	2018
Circadian Rhythm Sleep-Wake Phase Disorders. Neurologic clinics, 2019, Volume: 37, Issue:3 Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Sleep Disorders, Circadian Rhythm	2019
Health consequences of shift work and implications for structural design. Journal of perinatology : official journal of the California Perinatal Association, 2013, Volume: 33 Suppl 1 Topics: Animals; Breast Neoplasms; Circadian Rhythm; Hospital Design and Construction; Humans; Intensive Car	2013
Sleep-wake abnormalities in patients with cirrhosis. Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:2 Topics: Circadian Rhythm; Hepatic Encephalopathy; Homeostasis; Humans; Liver; Liver Cirrhosis; Melatonin; Sl	2014
Cell signaling, receptors, electrical effects and therapy in circadian rhythm. Journal of receptor and signal transduction research, 2013, Volume: 33, Issue:5 Topics: Animals; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Electroconvulsive Therapy; Humans; Jet	2013
Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks. Aging clinical and experimental research, 2013, Volume: 25, Issue:5 Topics: Animals; Carcinogenesis; Humans; Melatonin; Mood Disorders; Neoplasms; Sleep Disorders, Circadian Rh	2013
Circadian rhythm disorders among adolescents: assessment and treatment options. The Medical journal of Australia, 2013, Oct-21, Volume: 199, Issue:8 Topics: Adolescent; Anxiety Disorders; Australia; Comorbidity; Cross-Sectional Studies; Depressive Disorder;	2013
Twisting the night away: a review of the neurobiology, genetics, diagnosis, and treatment of shift work disorder. CNS spectrums, 2013, Volume: 18 Suppl 1 Topics: Antidepressive Agents; Biological Clocks; Central Nervous System Stimulants; Circadian Rhythm; Human	2013
Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders. Sleep medicine reviews, 2014, Volume: 18, Issue:4 Topics: Circadian Rhythm; Drug Administration Schedule; Humans; Light; Melatonin; Saliva; Sleep Disorders, C	2014
[Circadian rhythm sleep disorder]. Nihon rinsho. Japanese journal of clinical medicine, 2013, Volume: 71, Issue:12 Topics: Humans; Melatonin; Phototherapy; Receptors, Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Vit	2013
The relationship between bipolar disorder and biological rhythms. The Journal of clinical psychiatry, 2014, Volume: 75, Issue:4 Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Genetic Predisposition to Disease; Huma	2014
Spectral modulation of light wavelengths using optical filters: effect on melatonin secretion. Fertility and sterility, 2014, Volume: 102, Issue:2 Topics: Animals; Circadian Clocks; Circadian Rhythm; Humans; Light; Melatonin; Photoperiod; Phototherapy; Sl	2014
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. The Cochrane database of systematic reviews, 2014, Aug-12, Issue:8 Topics: Azabicyclo Compounds; Benzhydryl Compounds; Caffeine; Humans; Hypnotics and Sedatives; Melatonin; Mo	2014
Out of synch with society: an update on delayed sleep phase disorder. Current opinion in pulmonary medicine, 2014, Volume: 20, Issue:6 Topics: Benzofurans; Circadian Rhythm; Cyclopropanes; Environmental Exposure; Homeostasis; Humans; Light; Me	2014
Impacts of shift work on sleep and circadian rhythms. Pathologie-biologie, 2014, Volume: 62, Issue:5 Topics: Accidents; Arousal; Automobile Driving; Cardiovascular Diseases; Circadian Rhythm; Circadian Rhythm	2014
Effect of Light and Melatonin and Other Melatonin Receptor Agonists on Human Circadian Physiology. Sleep medicine clinics, 2015, Volume: 10, Issue:4 Topics: Central Nervous System Agents; Circadian Rhythm; Humans; Light; Melatonin; Phototherapy; Receptors,	2015
A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder. Attention deficit and hyperactivity disorders, 2017, Volume: 9, Issue:3 Topics: Attention Deficit Disorder with Hyperactivity; Chronotherapy; Circadian Clocks; Humans; Melatonin; S	2017
The relationship between insomnia and body temperatures. Sleep medicine reviews, 2008, Volume: 12, Issue:4 Topics: Arousal; Body Temperature Regulation; Circadian Rhythm; Homeostasis; Humans; Melatonin; Phototherapy	2008
The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Nature clinical practice. Neurology, 2008, Volume: 4, Issue:8 Topics: Animals; Humans; Light; Melatonin; Phototherapy; Sleep Disorders, Circadian Rhythm	2008
The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders. Journal of pineal research, 2009, Volume: 46, Issue:1 Topics: Electroencephalography; Humans; Melatonin; Pineal Gland; Sleep; Sleep Disorders, Circadian Rhythm; T	2009
A practical approach to circadian rhythm sleep disorders. Sleep medicine reviews, 2009, Volume: 13, Issue:1 Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;	2009
A practical approach to circadian rhythm sleep disorders. Sleep medicine reviews, 2009, Volume: 13, Issue:1 Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;	2009
A practical approach to circadian rhythm sleep disorders. Sleep medicine reviews, 2009, Volume: 13, Issue:1 Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;	2009
A practical approach to circadian rhythm sleep disorders. Sleep medicine reviews, 2009, Volume: 13, Issue:1 Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;	2009
Melatonin, sleep disturbance and cancer risk. Sleep medicine reviews, 2009, Volume: 13, Issue:4 Topics: Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Circadian Rhythm; Dietary Fats; Female;	2009
Chromotherapy in the regulation of neurohormonal balance in human brain--complementary application in modern psychiatric treatment. Collegium antropologicum, 2008, Volume: 32 Suppl 2 Topics: Color Therapy; Depressive Disorder; Humans; Melatonin; Seasonal Affective Disorder; Serotonin; Sleep	2008
[Depression and circadian rhythm]. L'Encephale, 2009, Volume: 35 Suppl 2 Topics: Biological Clocks; Circadian Rhythm; Depressive Disorder; Humans; Melatonin; Seasonal Affective Diso	2009
Melatonin and its agonists, circadian rhythms and psychiatry. African journal of psychiatry, 2009, Volume: 12, Issue:1 Topics: Adult; Aged; Central Nervous System Depressants; Child; Circadian Rhythm; Humans; Melatonin; Mental	2009
[Circadian rhythm sleep disorders]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2009, Sep-24, Volume: 129, Issue:18 Topics: Central Nervous System Depressants; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep Dis	2009
Managing the patient with shift-work disorder. The Journal of family practice, 2010, Volume: 59, Issue:1 Suppl Topics: Benzhydryl Compounds; Combined Modality Therapy; Diet; Environment; Exercise; Female; Humans; Life S	2010
Circadian rhythm sleep disorders. The Indian journal of medical research, 2010, Volume: 131 Topics: Biological Clocks; Circadian Rhythm; Guidelines as Topic; Humans; Jet Lag Syndrome; Melatonin; Polys	2010
Impact of the novel antidepressant agomelatine on disturbed sleep-wake cycles in depressed patients. Human psychopharmacology, 2010, Volume: 25, Issue:3 Topics: Acetamides; Animals; Antidepressive Agents; Depressive Disorder, Major; Humans; Melatonin; Randomize	2010
Investigational melatonin receptor agonists. Expert opinion on investigational drugs, 2010, Volume: 19, Issue:6 Topics: Animals; Circadian Rhythm; Drugs, Investigational; Half-Life; Humans; Insulin; Melatonin; Receptors,	2010
Circadian rhythms and clock genes in psychotic disorders. The Israel journal of psychiatry and related sciences, 2010, Volume: 47, Issue:1 Topics: Animals; Bipolar Disorder; Circadian Rhythm; CLOCK Proteins; Glycogen Synthase Kinase 3; Humans; Lit	2010
Melatonin: pharmacological aspects and clinical trends. The International journal of neuroscience, 2010, Volume: 120, Issue:9 Topics: Animals; Antidepressive Agents; Antioxidants; Depression; Free Radical Scavengers; Humans; Indenes;	2010
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Advances in therapy, 2010, Volume: 27, Issue:11 Topics: Acetamides; Benzofurans; Central Nervous System Depressants; Cyclopropanes; Depressive Disorder; Hum	2010
Sleep health and asynchronization. Brain & development, 2011, Volume: 33, Issue:3 Topics: Biological Clocks; Circadian Rhythm; Cortical Synchronization; Health; Humans; Japan; Melatonin; Ser	2011
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12 Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F	2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12 Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F	2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12 Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F	2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12 Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F	2010
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep, 2010, Volume: 33, Issue:12 Topics: Adult; Central Nervous System Depressants; Child; Drug Administration Schedule; Humans; Melatonin; S	2010
A circadian rhythm sleep disorder: melatonin resets the biological clock. The journal of the Royal College of Physicians of Edinburgh, 2010, Volume: 40, Issue:4 Topics: Biological Clocks; Humans; Male; Melatonin; Middle Aged; Neurotransmitter Agents; Sleep Disorders, C	2010
[Lights off? Neurobiological and pharmacological aspects of the melatonergic-serotonergic synergism]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2010, Volume: 12, Issue:4 Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Depression; Depressive Disorder; Drug Synergism	2010
Cognition in circadian rhythm sleep disorders. Progress in brain research, 2011, Volume: 190 Topics: Biological Clocks; Circadian Rhythm; Cognition; Humans; Jet Lag Syndrome; Light; Melatonin; Psychomo	2011
Jet lag and shift work sleep disorders: how to help reset the internal clock. Cleveland Clinic journal of medicine, 2011, Volume: 78, Issue:10 Topics: Actigraphy; Age Factors; Benzodiazepines; Caffeine; Central Nervous System Depressants; Central Nerv	2011
Melatonin for non-respiratory sleep disorders in visually impaired children. The Cochrane database of systematic reviews, 2011, Nov-09, Issue:11 Topics: Central Nervous System Depressants; Child; Disabled Children; Humans; Melatonin; Sleep Disorders, Ci	2011
The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease. Recent patents on endocrine, metabolic & immune drug discovery, 2011, Volume: 5, Issue:2 Topics: Alzheimer Disease; Circadian Rhythm; Cognitive Dysfunction; Female; Humans; Male; Melatonin; Sleep D	2011
Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:5 Topics: Brain; Child; Developmental Disabilities; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhyth	2012
Appropriate therapeutic selection for patients with shift work disorder. Sleep medicine, 2012, Volume: 13, Issue:4 Topics: Central Nervous System Depressants; Central Nervous System Stimulants; Circadian Rhythm; Humans; Hyp	2012
The role of melatonin in patients with chronic kidney disease undergoing haemodialysis. Journal of renal care, 2012, Volume: 38, Issue:2 Topics: Circadian Rhythm; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Kidney Fai	2012
Biological rhythms during residence in polar regions. Chronobiology international, 2012, Volume: 29, Issue:4 Topics: Acclimatization; Activities of Daily Living; Affect; Antarctic Regions; Arctic Regions; Biological C	2012
[Diagnosis and treatment in circadian rhythm sleep disorders]. Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70, Issue:7 Topics: Circadian Clocks; Humans; Melatonin; Phototherapy; Sleep Disorders, Circadian Rhythm	2012
Circadian typology: a comprehensive review. Chronobiology international, 2012, Volume: 29, Issue:9 Topics: Aging; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Cognition; Feeding and Eating Di	2012
Circadian-based new technologies for night workers. Industrial health, 2002, Volume: 40, Issue:3 Topics: Adaptation, Physiological; Circadian Rhythm; Exercise Therapy; Homeostasis; Humans; Melatonin; Perso	2002
Bright light, dark and melatonin can promote circadian adaptation in night shift workers. Sleep medicine reviews, 2002, Volume: 6, Issue:5 Topics: Adaptation, Physiological; Circadian Rhythm; Humans; Light; Melatonin; Sleep Disorders, Circadian Rh	2002
Circadian rhythm sleep disorders (CRSD). Sleep medicine reviews, 2002, Volume: 6, Issue:1 Topics: Antipsychotic Agents; Chronotherapy; Humans; Melatonin; Mental Disorders; Phototherapy; Sleep Disord	2002
The relevance of melatonin to sports medicine and science. Sports medicine (Auckland, N.Z.), 2003, Volume: 33, Issue:11 Topics: Aging; Body Temperature; Circadian Rhythm; Exercise; Humans; Hypothermia; Jet Lag Syndrome; Melatoni	2003
Melatonin for the treatment of disorders in circadian rhythm and sleep: could it form a basis for medication? Receptors & channels, 2003, Volume: 9, Issue:6 Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleep Deprivation; Sleep Disorders, Ci	2003
Circadian rhythm sleep disorders. The Medical clinics of North America, 2004, Volume: 88, Issue:3 Topics: Body Temperature; Chronobiology Disorders; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Photo	2004
[Circadian-rhythm sleep disorders]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2004, Volume: 106, Issue:3 Topics: Biogenic Amines; Biological Clocks; Biomarkers; Body Temperature; Circadian Rhythm; Diagnosis, Diffe	2004
Circadian rhythm disorders. Seminars in neurology, 2004, Volume: 24, Issue:3 Topics: Humans; Melatonin; Sleep Disorders, Circadian Rhythm	2004
Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep medicine, 2004, Volume: 5, Issue:6 Topics: Acetamides; Antioxidants; Humans; Hypothalamus; Indenes; Indoles; Melatonin; Receptors, Melatonin; S	2004
Delayed sleep phase syndrome: pathophysiology and treatment options. Sleep, 2004, Sep-15, Volume: 27, Issue:6 Topics: Antioxidants; Body Temperature; Chronotherapy; Circadian Rhythm; Combined Modality Therapy; Diagnosi	2004
Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade? Developmental medicine and child neurology, 2004, Volume: 46, Issue:11 Topics: Antioxidants; Brain; Child; Disability Evaluation; Disabled Children; Health Status; Humans; Melaton	2004
Melatonin as a chronobiotic. Sleep medicine reviews, 2005, Volume: 9, Issue:1 Topics: Animals; Chronobiology Phenomena; Circadian Rhythm; Humans; Hydrocortisone; Melatonin; Photoperiod;	2005
Effects of exogenous melatonin on sleep: a meta-analysis. Sleep medicine reviews, 2005, Volume: 9, Issue:1 Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni	2005
Effects of exogenous melatonin on sleep: a meta-analysis. Sleep medicine reviews, 2005, Volume: 9, Issue:1 Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni	2005
Effects of exogenous melatonin on sleep: a meta-analysis. Sleep medicine reviews, 2005, Volume: 9, Issue:1 Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni	2005
Effects of exogenous melatonin on sleep: a meta-analysis. Sleep medicine reviews, 2005, Volume: 9, Issue:1 Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni	2005
[Melatonin and its biological significance]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2004, Volume: 17, Issue:101 Topics: Affect; Aging; Circadian Rhythm; Humans; Immune System; Melatonin; Sleep Disorders, Circadian Rhythm	2004
Circadian rhythm sleep disorders. Primary care, 2005, Volume: 32, Issue:2 Topics: Humans; Melatonin; Primary Health Care; Sleep Disorders, Circadian Rhythm; Time Factors	2005
Prevalence and comorbidity of insomnia and effect on functioning in elderly populations. Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:7 Suppl Topics: Aged; Comorbidity; Humans; Hypnotics and Sedatives; Light; Melatonin; Prevalence; Sleep Disorders, C	2005
[Sleep and circadian rhythms in ageing]. Zeitschrift fur Gerontologie und Geriatrie, 2005, Volume: 38 Suppl 1 Topics: Aged, 80 and over; Aging; Circadian Rhythm; Humans; Light; Melatonin; Photic Stimulation; Sleep; Sle	2005
[Sleep disruption in shift work and jet lag: the role of the circadian timing system]. Praxis, 2005, Sep-21, Volume: 94, Issue:38 Topics: Adult; Antioxidants; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Humans; Hypnotic	2005
[Does exogenous melatonin prove to be effective in the prevention and treatment of pathologies associated with shift and night work?]. Medycyna pracy, 2005, Volume: 56, Issue:3 Topics: Adaptation, Physiological; Circadian Rhythm; Humans; Melatonin; Personnel Staffing and Scheduling; S	2005
The human circadian system in normal and disordered sleep. The Journal of clinical psychiatry, 2005, Volume: 66 Suppl 9 Topics: Biological Clocks; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Receptors, Melatoni	2005
The use of chronobiotics in the resynchronization of the sleep-wake cycle. Cancer causes & control : CCC, 2006, Volume: 17, Issue:4 Topics: Animals; Chronotherapy; Humans; Jet Lag Syndrome; Light; Melatonin; Sleep; Sleep Disorders, Circadia	2006
Sleep, rhythms and women's mood. Part II. Menopause. Sleep medicine reviews, 2006, Volume: 10, Issue:3 Topics: Adult; Circadian Rhythm; Female; Hormone Replacement Therapy; Hot Flashes; Humans; Hydrocortisone; M	2006
Melatonin and human rhythms. Chronobiology international, 2006, Volume: 23, Issue:1-2 Topics: Biological Clocks; Chronobiology Disorders; Chronobiology Phenomena; Circadian Rhythm; Humans; Light	2006
Melatonin in mood disorders. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:3 Topics: Antidepressive Agents; Biomarkers; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Depressi	2006
The brain's master circadian clock: implications and opportunities for therapy of sleep disorders. Sleep medicine reviews, 2007, Volume: 11, Issue:1 Topics: Antioxidants; Body Temperature; Circadian Rhythm; Humans; Hypothalamus; Melatonin; Phototherapy; Pit	2007
Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology. Eye (London, England), 2007, Volume: 21, Issue:7 Topics: Animals; Circadian Rhythm; Humans; Light; Melatonin; Ocular Physiological Phenomena; Pineal Gland; R	2007
Promoting adjustment of the sleep-wake cycle by chronobiotics. Physiology & behavior, 2007, Feb-28, Volume: 90, Issue:2-3 Topics: Chronobiology Phenomena; Chronotherapy; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders,	2007
[Synchronization and desynchronization of the biological clock in man]. L'Encephale, 2006, Volume: 32, Issue:5 Pt 2 Topics: Adult; Child; Chronobiology Disorders; Circadian Rhythm; Homeostasis; Humans; Melatonin; Mental Diso	2006
[Change in rhythms with age]. L'Encephale, 2006, Volume: 32, Issue:5 Pt 2 Topics: Activity Cycles; Aged; Aging; Arousal; Body Temperature Regulation; Circadian Rhythm; Hormones; Huma	2006
Shift work sleep disorder: burden of illness and approaches to management. Drugs, 2006, Volume: 66, Issue:18 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cost of Illness	2006
Melatonin and sleep disorders associated with intellectual disability: a clinical review. Journal of intellectual disability research : JIDR, 2007, Volume: 51, Issue:Pt 1 Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Dr	2007
Clinical management of delayed sleep phase disorder. Behavioral sleep medicine, 2007, Volume: 5, Issue:1 Topics: Antioxidants; Chronotherapy; Combined Modality Therapy; Humans; Melatonin; Phototherapy; Polysomnogr	2007
Treating chronobiological components of chronic insomnia. Sleep medicine, 2007, Volume: 8, Issue:6 Topics: Behavior Therapy; Biological Clocks; Body Temperature; Chronic Disease; Chronotherapy; Circadian Rhy	2007
A clinical approach to circadian rhythm sleep disorders. Sleep medicine, 2007, Volume: 8, Issue:6 Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Health Knowledge, Attitudes, Practice; Humans;	2007
Jet lag: trends and coping strategies. Lancet (London, England), 2007, Mar-31, Volume: 369, Issue:9567 Topics: Adaptation, Psychological; Humans; Jet Lag Syndrome; Melatonin; Sleep Disorders, Circadian Rhythm; S	2007
Circadian rhythm sleep disorders in the blind and their treatment with melatonin. Sleep medicine, 2007, Volume: 8, Issue:6 Topics: Blindness; Chronotherapy; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhy	2007
Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome. Sleep medicine reviews, 2007, Volume: 11, Issue:6 Topics: Adolescent; Biological Clocks; Body Temperature; Circadian Rhythm; Humans; Melatonin; Phototherapy;	2007
Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Sleep, 2007, Volume: 30, Issue:11 Topics: Antioxidants; Humans; Melatonin; Phototherapy; Polysomnography; Sleep; Sleep Disorders, Circadian Rh	2007
Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review. Sleep, 2007, Volume: 30, Issue:11 Topics: Adult; Antioxidants; Central Nervous System Stimulants; Drug Therapy; Female; Humans; Male; Melatoni	2007
Circadian rhythmicity and the pharmacologic management of insomnia. The American journal of managed care, 2007, Volume: 13, Issue:5 Suppl Topics: Chronotherapy; Cost-Benefit Analysis; Humans; Hypnotics and Sedatives; Managed Care Programs; Melato	2007
Diagnosis of circadian rhythm sleep disorders. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 2008, Volume: 34, Issue:3 Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Phototherapy; Polysomnograph	2008
Melatonin, sleep, and circadian rhythm disorders. Seminars in clinical neuropsychiatry, 2000, Volume: 5, Issue:1 Topics: Brain; Brain Mapping; Circadian Rhythm; Humans; Melatonin; Pituitary Gland; Risk Factors; Sleep Diso	2000
Sleep/wake cycle and circadian disturbances in shift work: strategies for their management--a review. Annals of the Academy of Medicine, Singapore, 2000, Volume: 29, Issue:1 Topics: Humans; Lighting; Melatonin; Occupational Health; Personnel Staffing and Scheduling; Sleep Disorders	2000
Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. CNS drugs, 2001, Volume: 15, Issue:4 Topics: Animals; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Sleep; Sleep Disorders, C	2001
Health in a 24-h society. Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286 Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,	2001
Health in a 24-h society. Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286 Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,	2001
Health in a 24-h society. Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286 Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,	2001
Health in a 24-h society. Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286 Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,	2001
Sleep, sleepiness, and alcohol use. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2001, Volume: 25, Issue:2 Topics: Alcohol Drinking; Alcoholism; Animals; Dose-Response Relationship, Drug; Ethanol; Humans; Melatonin;	2001
[Physiology of the biological clock and the relation of circadian rhythm disorders to illnesses]. Duodecim; laaketieteellinen aikakauskirja, 1999, Volume: 115, Issue:5 Topics: Animals; Biological Clocks; Blindness; Chronobiology Disorders; Humans; Jet Lag Syndrome; Light; Mel	1999
[Delayed wakefulness-sleep rhythm syndrome and melatonin. Synthesis of existing studies]. Revue neurologique, 2001, Volume: 157, Issue:11 Pt 2 Topics: Circadian Rhythm; Clinical Trials as Topic; Humans; Melatonin; Sleep Disorders, Circadian Rhythm; Tr	2001
[Delayed sleep phase insomnia]. Duodecim; laaketieteellinen aikakauskirja, 1999, Volume: 115, Issue:24 Topics: Circadian Rhythm; Diagnosis, Differential; Humans; Melatonin; Quality of Life; Severity of Illness I	1999
[Melatonin treatment of sleep disorders in disabled children]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2002, Apr-20, Volume: 122, Issue:10 Topics: Administration, Oral; Child; Child, Preschool; Developmental Disabilities; Disabled Children; Humans	2002

Article	Year
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults. Journal of pineal research, 2022, Volume: 73, Issue:1 Topics: Aged; Circadian Rhythm; Cross-Over Studies; Humans; Melatonin; Middle Aged; Quality of Life; Sleep;	2022
Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. BMJ open, 2022, 07-04, Volume: 12, Issue:7 Topics: Anticonvulsants; Child, Preschool; Dietary Supplements; Humans; Infant; Melatonin; Neuroprotective A	2022
Attention-Deficit/Hyperactivity Disorder and Delayed Sleep Phase Syndrome in Adults: A Randomized Clinical Trial on the Effects of Chronotherapy on Sleep. Journal of biological rhythms, 2022, Volume: 37, Issue:6 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chronotherapy; Circadian Rhythm; Humans; Melat	2022
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood. Journal of biological rhythms, 2023, Volume: 38, Issue:1 Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep	2023
Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: a randomized clinical trial. Chronobiology international, 2021, Volume: 38, Issue:2 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chronotherapy; Circadian Rhythm; Humans; Light	2021
Identification of a Preliminary Plasma Metabolome-based Biomarker for Circadian Phase in Humans. Journal of biological rhythms, 2021, Volume: 36, Issue:4 Topics: Biomarkers; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Metabolome; Sleep; Sleep Disor	2021
Randomised controlled trial of the efficacy of a blue-enriched light intervention to improve alertness and performance in night shift workers. Occupational and environmental medicine, 2017, Volume: 74, Issue:11 Topics: Adult; Attention; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Sleep; Sleep Disorders,	2017
Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder. Sleep medicine, 2019, Volume: 58 Topics: Adult; Australia; Biological Variation, Population; Case-Control Studies; Central Nervous System Dep	2019
Long-term effects of melatonin on quality of life and sleep in haemodialysis patients (Melody study): a randomized controlled trial. British journal of clinical pharmacology, 2013, Volume: 76, Issue:5 Topics: Actigraphy; Aged; Antioxidants; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies;	2013
Effects of filtering visual short wavelengths during nocturnal shiftwork on sleep and performance. Chronobiology international, 2013, Volume: 30, Issue:8 Topics: Adult; Affect; Analysis of Variance; Circadian Rhythm; Employee Performance Appraisal; Female; Human	2013
A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: effects on subjective and objective sleepiness and cognitive function. Journal of biological rhythms, 2013, Volume: 28, Issue:5 Topics: Adolescent; Adult; Circadian Rhythm; Cognition; Double-Blind Method; Fatigue; Female; Humans; Male;	2013
Glucocorticoids entrain molecular clock components in human peripheral cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:4 Topics: Adult; ARNTL Transcription Factors; Circadian Rhythm; Double-Blind Method; Drug Administration Sched	2015
The effects of kidney transplantation on sleep, melatonin, circadian rhythm and quality of life in kidney transplant recipients and living donors. Nephron, 2015, Volume: 129, Issue:1 Topics: Adult; Aged; Blood Pressure; Body Temperature; Circadian Rhythm; Female; Humans; Kidney Failure, Chr	2015
Sleep deficits in the High Arctic summer in relation to light exposure and behaviour: use of melatonin as a countermeasure. Sleep medicine, 2015, Volume: 16, Issue:3 Topics: Actigraphy; Adult; Arctic Regions; Canada; Central Nervous System Depressants; Circadian Rhythm; Fem	2015
Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms. Sleep medicine, 2015, Volume: 16, Issue:6 Topics: Affect; Aged; Arousal; Blindness; Caffeine; Circadian Clocks; Humans; Male; Melatonin; Middle Aged;	2015
Home dim light melatonin onsets with measures of compliance in delayed sleep phase disorder. Journal of sleep research, 2016, Volume: 25, Issue:3 Topics: Adolescent; Adult; Circadian Rhythm; Female; Housing; Humans; Light; Lighting; Melatonin; Middle Age	2016
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome. Sleep medicine, 2009, Volume: 10, Issue:5 Topics: Adolescent; Adult; Circadian Rhythm; Cohort Studies; Female; Humans; Light; Male; Melatonin; Polysom	2009
The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study). British journal of clinical pharmacology, 2009, Volume: 67, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Female; H	2009
Night shift performance is improved by a compromise circadian phase position: study 3. Circadian phase after 7 night shifts with an intervening weekend off. Sleep, 2008, Volume: 31, Issue:12 Topics: Adaptation, Physiological; Adult; Arousal; Attention; Chronotherapy; Circadian Rhythm; Feasibility S	2008
Use of transdermal melatonin delivery to improve sleep maintenance during daytime. Clinical pharmacology and therapeutics, 2009, Volume: 86, Issue:4 Topics: Administration, Cutaneous; Adult; Body Temperature; Central Nervous System Depressants; Circadian Rh	2009
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. Sleep medicine, 2010, Volume: 11, Issue:2 Topics: Adult; Central Nervous System Depressants; Circadian Rhythm; Cross-Over Studies; Depression; Double-	2010
Lack of short-wavelength light during the school day delays dim light melatonin onset (DLMO) in middle school students. Neuro endocrinology letters, 2010, Volume: 31, Issue:1 Topics: Adolescent; Biological Clocks; Circadian Rhythm; Eyeglasses; Female; Humans; Light; Lighting; Male;	2010
Effects of an advanced sleep schedule and morning short wavelength light exposure on circadian phase in young adults with late sleep schedules. Sleep medicine, 2011, Volume: 12, Issue:7 Topics: Affect; Circadian Rhythm; Color; Dose-Response Relationship, Radiation; Female; Humans; Light; Male;	2011
Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stress. Sleep medicine, 2011, Volume: 12, Issue:9 Topics: Central Nervous System Depressants; Child; Child Behavior; Child, Preschool; Drug Administration Sch	2011
The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans. Journal of pineal research, 2012, Volume: 53, Issue:1 Topics: Adult; Circadian Clocks; Cross-Sectional Studies; Electroencephalography; Female; Humans; Male; Mela	2012
Intrinsic circadian period of sighted patients with circadian rhythm sleep disorder, free-running type. Biological psychiatry, 2013, Jan-01, Volume: 73, Issue:1 Topics: Adolescent; Adult; Case-Control Studies; Chronotherapy; Circadian Rhythm; Female; Humans; Indenes; M	2013
Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness. Sleep, 2004, May-01, Volume: 27, Issue:3 Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Circadian Rhythm;	2004
Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain & development, 2004, Volume: 26, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Cros	2004
Phase-dependent treatment of delayed sleep phase syndrome with melatonin. Sleep, 2005, Volume: 28, Issue:10 Topics: Adult; Antioxidants; Circadian Rhythm; Drug Administration Schedule; Female; Humans; Male; Melatonin	2005
Morning melatonin has limited benefit as a soporific for daytime sleep after night work. Chronobiology international, 2005, Volume: 22, Issue:5 Topics: Adult; Circadian Rhythm; Darkness; Delayed-Action Preparations; Female; Humans; Light; Male; Melaton	2005
Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep, 2006, Volume: 29, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Antioxidants; Body Temperature; Circadian Rhythm; Double-Bl	2006
Subjective and objective measures of adaptation and readaptation to night work on an oil rig in the North Sea. Sleep, 2006, Volume: 29, Issue:6 Topics: Adaptation, Physiological; Adult; Antioxidants; Cross-Over Studies; Disorders of Excessive Somnolenc	2006
Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work. Scandinavian journal of work, environment & health, 2007, Volume: 33, Issue:3 Topics: Adaptation, Psychological; Adult; Analysis of Variance; Circadian Rhythm; Cross-Over Studies; Double	2007
Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. Journal of pineal research, 2007, Volume: 43, Issue:4 Topics: Central Nervous System Depressants; Child; Cross-Over Studies; Delayed-Action Preparations; Double-B	2007
Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. Journal of the American Geriatrics Society, 2008, Volume: 56, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Circadian Rhythm; Female; Humans; Linear M	2008
A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. Journal of pineal research, 2008, Volume: 44, Issue:1 Topics: Adolescent; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive; Child	2008
Effects of melatonin administration on daytime sleep after simulated night shift work. Journal of sleep research, 2001, Volume: 10, Issue:3 Topics: Adolescent; Adult; Antioxidants; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Electroc	2001
Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:2 Topics: Adjuvants, Immunologic; Adult; Affect; Body Temperature; Circadian Rhythm; Female; Humans; Jet Lag S	2002
Bright-light mask treatment of delayed sleep phase syndrome. Journal of biological rhythms, 2002, Volume: 17, Issue:1 Topics: Adolescent; Adult; Affect; Circadian Rhythm; Double-Blind Method; Female; Follow-Up Studies; Humans;	2002

melatonin and Advanced Sleep Phase Syndrome