melatonin has been researched along with Acute Lung Injury in 27 studies
Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paraquat (PQ) poisoning can result in multiple organ dysfunction syndrome, mainly manifesting as acute lung injury and acute respiratory distress syndrome." | 8.31 | Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression. ( Shen, H; Yin, Y, 2023) |
| "The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR)." | 8.02 | Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model. ( Brandão, JCM; Camargo, CR; Leite, AA; Marinho, M; Oliveira-Junior, IS; Reiter, RJ; Sakae, TM, 2021) |
| " Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue inflammation and oxidative damage induced by exposure to CCl4 in rats." | 7.91 | Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response. ( Krtinic, D; Mirkovic, MV; Nickovic, V; Radovic, M; Rancic, M; Ristic, L; Sokolovic, D; Toskic, DR; Vujnovic Zivkovic, ZN; Zivkovic, JB, 2019) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 7.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "To investigate whether therapeutic treatment with melatonin could protect rats against acute pancreatitis and its associated lung injury." | 7.78 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22. ( Chen, MJ; Huai, JP; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Ye, XH, 2012) |
| "To observe the expression of P-selectin (Ps), intercellular adhesion molecule-1 (ICAM-1) and nuclear factor-kappa B (NF-kappaB) in lung tissues of acute lung injury (ALI) rat model induced by oleic acid (OA) and to explore the protective effects of melatonin (MT) in lung tissues in rats." | 7.77 | [Protective function of melatonin to acute lung injury and its mechanisms in rats caused by oleic acid]. ( Ding, CH; Gao, L; Gu, WW; Ma, WZ; Ma, YL; Zhang, Z, 2011) |
| "To investigate the protective effect of melatonin (MT) on lung tissues during acute lung injury (ALI) in rats and its possible mechanism." | 7.76 | [Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats]. ( Ding, CH; Dong, YJ; Gu, WW; Suo, XH, 2010) |
| "To observe the expression of p-p38 mitogen-activated protein kinase in lung tissues of acute lung injury rat model induced by lipopolysaccharide (LPS) and to explore the protective effects of melatonin (MT) in lung tissues in rats." | 7.76 | [Protective effects of melatonin in acute lung injury rats caused by LPS]. ( Ding, CH; Dong, YJ; Gu, WW; Ma, YL; Zhang, Z, 2010) |
| "Melatonin reduces acute lung injury in endotoxemic rats by attenuating pulmonary inflammation and inhibiting NF-kappaB activation." | 7.75 | Melatonin reduces acute lung injury in endotoxemic rats. ( Jiang, YX; Shang, Y; Wu, Y; Wu, ZY; Xu, SP; Yao, SL; Yuan, SY, 2009) |
| "Melatonin has multiple antioxidant action and anti-inflammatory effects, including regulating mitophagy and inflammatory cytokine expression." | 5.91 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy. ( Li, S; Ling, J; Xiong, F; Xu, T; Yu, S, 2023) |
| "Acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS) is featured by intensive inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis." | 5.72 | Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis. ( Ding, ZX; Fei, GH; Kang, JY; Shen, JL; Sun, Y; Wang, YG; Wei, YY; Wu, HM; Xu, MM; Zhang, DW, 2022) |
| "Melatonin pretreatment significantly inhibited pathological injury, inflammatory response, oxidative stress, and apoptosis in LPS-treated lung tissues and LPS-treated lung epithelial cells." | 5.72 | A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2. ( Chenzhen, X; Donghang, L; Guorui, L; Ning, L; Qing, G; Rui, X; Tinglv, F; Xiaojing, W, 2022) |
| "Melatonin is a well-known anti-inflammatory molecule, which has proven to be effective in ALI induced by many conditions." | 5.43 | Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. ( Gao, GF; Grailer, JJ; Li, X; Tan, DX; Wang, M; Wang, N; Ward, PA; Yao, J; Zhang, Y; Zhong, R, 2016) |
| "Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects." | 5.42 | Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects. ( An, H; Jiang, C; Yang, B; Zhang, H; Zhao, D; Zhou, L, 2015) |
| "Paraquat (PQ) poisoning can result in multiple organ dysfunction syndrome, mainly manifesting as acute lung injury and acute respiratory distress syndrome." | 4.31 | Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression. ( Shen, H; Yin, Y, 2023) |
| "The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR)." | 4.02 | Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model. ( Brandão, JCM; Camargo, CR; Leite, AA; Marinho, M; Oliveira-Junior, IS; Reiter, RJ; Sakae, TM, 2021) |
| " Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue inflammation and oxidative damage induced by exposure to CCl4 in rats." | 3.91 | Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response. ( Krtinic, D; Mirkovic, MV; Nickovic, V; Radovic, M; Rancic, M; Ristic, L; Sokolovic, D; Toskic, DR; Vujnovic Zivkovic, ZN; Zivkovic, JB, 2019) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 3.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "To investigate whether therapeutic treatment with melatonin could protect rats against acute pancreatitis and its associated lung injury." | 3.78 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22. ( Chen, MJ; Huai, JP; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Ye, XH, 2012) |
| "To observe the expression of P-selectin (Ps), intercellular adhesion molecule-1 (ICAM-1) and nuclear factor-kappa B (NF-kappaB) in lung tissues of acute lung injury (ALI) rat model induced by oleic acid (OA) and to explore the protective effects of melatonin (MT) in lung tissues in rats." | 3.77 | [Protective function of melatonin to acute lung injury and its mechanisms in rats caused by oleic acid]. ( Ding, CH; Gao, L; Gu, WW; Ma, WZ; Ma, YL; Zhang, Z, 2011) |
| "To investigate the protective effect of melatonin (MT) on lung tissues during acute lung injury (ALI) in rats and its possible mechanism." | 3.76 | [Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats]. ( Ding, CH; Dong, YJ; Gu, WW; Suo, XH, 2010) |
| "To observe the expression of p-p38 mitogen-activated protein kinase in lung tissues of acute lung injury rat model induced by lipopolysaccharide (LPS) and to explore the protective effects of melatonin (MT) in lung tissues in rats." | 3.76 | [Protective effects of melatonin in acute lung injury rats caused by LPS]. ( Ding, CH; Dong, YJ; Gu, WW; Ma, YL; Zhang, Z, 2010) |
| "Melatonin reduces acute lung injury in endotoxemic rats by attenuating pulmonary inflammation and inhibiting NF-kappaB activation." | 3.75 | Melatonin reduces acute lung injury in endotoxemic rats. ( Jiang, YX; Shang, Y; Wu, Y; Wu, ZY; Xu, SP; Yao, SL; Yuan, SY, 2009) |
| "To investigate the protective effect of melatonin (MT) on lung tissues during acute lung injury (ALI) in rats and its possible mechanism." | 3.74 | [Effects of melatonin on anti-oxidative function of lung injury induced by lipopolysaccharide in rats and ICAM-1 expression]. ( Ding, CH; Dong, CF; Ling, YL; Suo, XH; Zhang, JY, 2008) |
| "Melatonin has multiple antioxidant action and anti-inflammatory effects, including regulating mitophagy and inflammatory cytokine expression." | 1.91 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy. ( Li, S; Ling, J; Xiong, F; Xu, T; Yu, S, 2023) |
| "Acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS) is featured by intensive inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis." | 1.72 | Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis. ( Ding, ZX; Fei, GH; Kang, JY; Shen, JL; Sun, Y; Wang, YG; Wei, YY; Wu, HM; Xu, MM; Zhang, DW, 2022) |
| "Melatonin pretreatment significantly inhibited pathological injury, inflammatory response, oxidative stress, and apoptosis in LPS-treated lung tissues and LPS-treated lung epithelial cells." | 1.72 | A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2. ( Chenzhen, X; Donghang, L; Guorui, L; Ning, L; Qing, G; Rui, X; Tinglv, F; Xiaojing, W, 2022) |
| "Treatment with melatonin upregulated Nrf2 expression, inhibited LPS-induced cell morphological change, reversed the expressions of EMT-related proteins, and reduced reactive oxygen species (ROS) production in A549 cells, as well as the levels of malondialdehyde (MDA) and anti-oxidative enzymes." | 1.56 | Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway. ( Ding, Z; Fei, G; Ji, S; Kang, J; Li, J; Wang, Y; Wu, X; Zhang, W, 2020) |
| "Melatonin is a well-known anti-inflammatory molecule, which has proven to be effective in ALI induced by many conditions." | 1.43 | Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. ( Gao, GF; Grailer, JJ; Li, X; Tan, DX; Wang, M; Wang, N; Ward, PA; Yao, J; Zhang, Y; Zhong, R, 2016) |
| "Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects." | 1.42 | Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects. ( An, H; Jiang, C; Yang, B; Zhang, H; Zhao, D; Zhou, L, 2015) |
| "Melatonin pretreatment prior to liver I/R can effectively reduce the pulmonary microvascular permeability and attenuate lipid peroxidation in the lungs." | 1.38 | Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats. ( Chen, CF; Chen, KH; Chiu, MH; Su, CL; Wang, D; Wang, JJ, 2012) |
| "Melatonin pretreatment also protected the liver against I/R injury (P < ." | 1.38 | Liver reperfusion-induced decrease in dynamic compliance and increase in airway resistance are ameliorated by preischemic treatment with melatonin through scavenging hydroxyl radicals in rat lungs. ( Chen, CF; Su, CL; Wang, D; Wang, JJ; Yeh, JH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 14 (51.85) | 24.3611 |
| 2020's | 11 (40.74) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, JY | 4 |
| Xu, MM | 4 |
| Sun, Y | 1 |
| Ding, ZX | 1 |
| Wei, YY | 4 |
| Zhang, DW | 1 |
| Wang, YG | 4 |
| Shen, JL | 4 |
| Wu, HM | 4 |
| Fei, GH | 4 |
| Ji, S | 4 |
| Wei, SL | 3 |
| Ye, JJ | 3 |
| Ning, L | 3 |
| Rui, X | 3 |
| Guorui, L | 3 |
| Tinglv, F | 3 |
| Donghang, L | 3 |
| Chenzhen, X | 3 |
| Xiaojing, W | 3 |
| Qing, G | 3 |
| Yin, Y | 2 |
| Shen, H | 1 |
| Qin, T | 1 |
| Feng, D | 1 |
| Zhou, B | 1 |
| Bai, L | 1 |
| Zhou, S | 1 |
| Du, J | 1 |
| Xu, G | 1 |
| Xiao, X | 1 |
| Chen, S | 1 |
| Huang, Z | 1 |
| Han, X | 1 |
| Dou, C | 1 |
| Kang, J | 2 |
| Wang, T | 1 |
| Xie, H | 1 |
| Zhang, L | 2 |
| Hei, Z | 1 |
| Li, H | 1 |
| Yao, W | 1 |
| Ling, J | 1 |
| Yu, S | 1 |
| Xiong, F | 1 |
| Xu, T | 1 |
| Li, S | 1 |
| Supinski, GS | 1 |
| Schroder, EA | 1 |
| Callahan, LA | 1 |
| Radovic, M | 1 |
| Ristic, L | 1 |
| Krtinic, D | 1 |
| Rancic, M | 1 |
| Nickovic, V | 1 |
| Vujnovic Zivkovic, ZN | 1 |
| Zivkovic, JB | 1 |
| Mirkovic, MV | 1 |
| Toskic, DR | 1 |
| Sokolovic, D | 1 |
| Zhang, R | 1 |
| Wang, X | 1 |
| Ni, L | 1 |
| Di, X | 1 |
| Ma, B | 1 |
| Niu, S | 1 |
| Liu, C | 1 |
| Reiter, RJ | 2 |
| Ding, Z | 1 |
| Wu, X | 1 |
| Wang, Y | 1 |
| Zhang, W | 1 |
| Li, J | 1 |
| Fei, G | 1 |
| Leite, AA | 1 |
| Brandão, JCM | 1 |
| Sakae, TM | 1 |
| Marinho, M | 1 |
| Camargo, CR | 1 |
| Oliveira-Junior, IS | 1 |
| Taslidere, E | 1 |
| Esrefoglu, M | 1 |
| Elbe, H | 1 |
| Cetin, A | 1 |
| Ates, B | 1 |
| Shim, DW | 1 |
| Shin, HJ | 1 |
| Han, JW | 1 |
| Ji, YE | 1 |
| Jang, CH | 1 |
| Koppula, S | 1 |
| Kang, TB | 1 |
| Lee, KH | 1 |
| Zhou, L | 1 |
| Zhao, D | 1 |
| An, H | 1 |
| Zhang, H | 1 |
| Jiang, C | 1 |
| Yang, B | 1 |
| Zhang, Y | 1 |
| Li, X | 2 |
| Grailer, JJ | 1 |
| Wang, N | 1 |
| Wang, M | 1 |
| Yao, J | 1 |
| Zhong, R | 1 |
| Gao, GF | 1 |
| Ward, PA | 1 |
| Tan, DX | 1 |
| Ozdinc, S | 1 |
| Oz, G | 1 |
| Ozdemir, C | 1 |
| Kilic, I | 1 |
| Karakaya, Z | 1 |
| Bal, A | 1 |
| Koken, T | 1 |
| Solak, O | 1 |
| Shang, Y | 1 |
| Xu, SP | 1 |
| Wu, Y | 1 |
| Jiang, YX | 1 |
| Wu, ZY | 1 |
| Yuan, SY | 1 |
| Yao, SL | 1 |
| Dong, YJ | 2 |
| Ding, CH | 4 |
| Gu, WW | 3 |
| Suo, XH | 2 |
| Zhang, JY | 1 |
| Dong, CF | 1 |
| Ling, YL | 1 |
| Zhang, Z | 2 |
| Ma, YL | 2 |
| Gao, L | 1 |
| Ma, WZ | 1 |
| Chiu, MH | 1 |
| Su, CL | 2 |
| Chen, CF | 2 |
| Chen, KH | 1 |
| Wang, D | 2 |
| Wang, JJ | 2 |
| Yeh, JH | 1 |
| Wu, WS | 1 |
| Chou, MT | 1 |
| Chao, CM | 1 |
| Chang, CK | 1 |
| Lin, MT | 1 |
| Chang, CP | 1 |
| Huai, JP | 1 |
| Sun, XC | 1 |
| Chen, MJ | 1 |
| Jin, Y | 1 |
| Ye, XH | 1 |
| Wu, JS | 1 |
| Huang, ZM | 1 |
| Shen, J | 1 |
| Gan, ZY | 1 |
| He, DK | 1 |
| Zhong, ZY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts.[NCT04353128] | Phase 2/Phase 3 | 450 participants (Actual) | Interventional | 2020-04-20 | Completed | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for melatonin and Acute Lung Injury
| Article | Year |
|---|---|
Mitochondria and Critical Illness.
Topics: Acute Lung Injury; Alarmins; Antioxidants; Cesium; Critical Illness; DNA, Mitochondrial; Humans; Mel | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
COVID-19: Melatonin as a potential adjuvant treatment.
Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; | 2020 |
Melatonin: is it an effective antioxidant for pulmonary contusion?
Topics: Acute Lung Injury; Animals; Antioxidants; Blood Gas Analysis; Contusions; Drug Evaluation, Preclinic | 2016 |
24 other studies available for melatonin and Acute Lung Injury
| Article | Year |
|---|---|
Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis.
Topics: Acute Lung Injury; Animals; Heme Oxygenase-1; Lipopolysaccharides; Melatonin; Membrane Proteins; Mic | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Apolipoprotein E3; Apolipoproteins E; Influenza A Virus, H3N2 Subtype; M | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression.
Topics: Acute Lung Injury; Animals; DNA, Mitochondrial; Lung; Melatonin; Paraquat; Protein Kinases | 2023 |
Melatonin attenuates lipopolysaccharide-induced immune dysfunction in dendritic cells.
Topics: Acute Lung Injury; Animals; Body Weight; Cytokines; Dendritic Cells; Interleukin-12; Interleukin-17; | 2023 |
SerpinB1 is required for Rev-erbα-mediated protection against acute lung injury induced by lipopolysaccharide-in mice.
Topics: Acute Lung Injury; Animals; Humans; Lipopolysaccharides; Lung; Melatonin; Mice; Mice, Inbred C57BL; | 2023 |
Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy.
Topics: Acute Lung Injury; Animals; Inflammation; Melatonin; Mice; Mice, Inbred C57BL; Mitophagy; Sepsis | 2023 |
Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response.
Topics: Acute Lung Injury; Animals; Antioxidants; Arginine; Carbon Tetrachloride; Inflammation; Melatonin; N | 2019 |
Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway.
Topics: A549 Cells; Acute Lung Injury; Alveolar Epithelial Cells; Antioxidants; Epithelial-Mesenchymal Trans | 2020 |
Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model.
Topics: Acetylcysteine; Acute Lung Injury; Animals; Ischemia; Melatonin; Rats; Rats, Wistar; Reperfusion; Re | 2021 |
Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Fe | 2014 |
A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.
Topics: Acute Lung Injury; Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Cell Li | 2015 |
Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Cytoki | 2015 |
Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Blotting, Western; Disease Models, Animal; Enz | 2016 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
Melatonin reduces acute lung injury in endotoxemic rats.
Topics: Acute Lung Injury; Animals; Blotting, Western; Endotoxemia; Interleukin-10; Lipopolysaccharides; Lun | 2009 |
[Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats].
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Lung; Melatonin; p38 Mitogen-Activated Protein K | 2010 |
[Effects of melatonin on anti-oxidative function of lung injury induced by lipopolysaccharide in rats and ICAM-1 expression].
Topics: Acute Lung Injury; Animals; Antioxidants; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Ma | 2008 |
[Protective effects of melatonin in acute lung injury rats caused by LPS].
Topics: Acute Lung Injury; Animals; Lipopolysaccharides; Lung; Male; Melatonin; p38 Mitogen-Activated Protei | 2010 |
[Protective function of melatonin to acute lung injury and its mechanisms in rats caused by oleic acid].
Topics: Acute Lung Injury; Animals; Down-Regulation; Intercellular Adhesion Molecule-1; Male; Melatonin; NF- | 2011 |
Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Capillary Permeability; Cytoprotection; Disease Models, An | 2012 |
Liver reperfusion-induced decrease in dynamic compliance and increase in airway resistance are ameliorated by preischemic treatment with melatonin through scavenging hydroxyl radicals in rat lungs.
Topics: Acute Lung Injury; Airway Resistance; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bi | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22.
Topics: Acute Disease; Acute Lung Injury; Amylases; Animals; Immunity, Innate; Interleukin-22; Interleukins; | 2012 |
[Protective effect of melatonin in rats with phosgene-induced lung injury].
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Male; Malondialdehyde; Melatonin; NF-kappa B; Ni | 2012 |