melatonin has been researched along with Acute Liver Injury, Drug-Induced in 53 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other organs and many studies confirm its benefits against oxidative stress including lipid peroxidation, protein mutilation and molecular degeneration in various organs, including the liver." | 6.53 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review. ( Alatorre-Jiménez, MA; Almeida-Souza, P; Cantín-Golet, A; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Reiter, RJ; Reyes-Gonzales, MC; Ruiz-Ruiz, FJ; Tan, DX, 2016) |
| " The purpose of the current study was to reveal the possible protective effects of melatonin against AA-induced hepatic oxidative stress, hepatic inflammation, and hepatocellular proliferation in pinealectomized rats." | 4.31 | Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation. ( Altinoz, E; Bicer, Y; Elbe, H; Karayakali, M; Onal, MO; Ozturk, I, 2023) |
| "Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other organs and many studies confirm its benefits against oxidative stress including lipid peroxidation, protein mutilation and molecular degeneration in various organs, including the liver." | 2.53 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review. ( Alatorre-Jiménez, MA; Almeida-Souza, P; Cantín-Golet, A; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Reiter, RJ; Reyes-Gonzales, MC; Ruiz-Ruiz, FJ; Tan, DX, 2016) |
| "With the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much." | 1.91 | Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling. ( Chen, YC; Hsiao, CC; Hsieh, HY; Huang, LT; Huang, YC; Lo, WS; Sheen, JM; Wang, SC, 2023) |
| "Melatonin levels were significantly decreased in both Pnx mice and TCE-treated animals at both light regimens." | 1.72 | Constant light exposure and/or pinealectomy increases susceptibility to trichloroethylene-induced hepatotoxicity and liver cancer in male mice. ( Abdraboh, ME; Amer, ME; El-Missiry, MA; Elhamed, DSA; Othman, AI; Taha, AN, 2022) |
| "Valproic acid (VPA) is a anticonvulsant and mood-stabilizing agent used to treat epilepsy in patients of all ages." | 1.56 | Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats. ( Buyuk, B; Coskun, O; Ovali, MA; Oztopuz, O; Sehitoglu, MH; Turkon, H; Uzun, M, 2020) |
| "Melatonin has been demonstrated to have anti-inflammatory and antioxidant effects." | 1.46 | Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway. ( He, X; Huang, H; Liu, W; Wang, J; Wei, Z; Yang, Z; Zhang, J; Zhang, Y, 2017) |
| "Melatonin is an indolamine synthesized in the pineal gland that has a wide range of physiological functions, and it has been under clinical investigation for expanded applications." | 1.40 | Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. ( Cao, Z; Duan, W; Guo, P; He, M; Li, M; Li, R; Li, Y; Liu, C; Lu, Y; Pi, H; Tian, L; Xie, J; Xu, S; Yu, Z; Zhang, L; Zhou, Z, 2014) |
| "The melatonin group was injected only with 10 mg/kg of melatonin every day until killing." | 1.39 | Protective role of melatonin supplementation against nicotine-induced liver damage in mouse. ( Eren, B; Mercan, S, 2013) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Melatonin treatment (50 mg/kg/daily, i." | 1.35 | Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. ( Hong, SS; Hong, SW; Jung, KH; Lee, DH; Zheng, HM, 2009) |
| "Melatonin is known to be a free radical scavenger and an antioxidant agent." | 1.35 | Melatonin prevents cyclosporine-induced hepatotoxicity in rats. ( Atasever, A; Esrefoglu, M; Kurus, M; Sogutlu, G, 2009) |
| "Melatonin is a cytokine modulator, antioxidant and anti-apoptotic agent." | 1.34 | Melatonin attenuates lipopolysaccharide (LPS)-induced apoptotic liver damage in D-galactosamine-sensitized mice. ( Lv, JW; Ning, H; Wang, H; Wei, W; Xu, DX, 2007) |
| "Melatonin (Mel) has been successfully used as a potent antioxidant against many pathophysiological states." | 1.33 | Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver. ( Bianchi, R; Buffoli, B; Rezzani, R; Rodella, L; Stacchiotti, A, 2005) |
| "Melatonin co-treatment to the lead-administered rats attenuated the increase of LPO and restored the activity of SOD and levels of GSH as well as the mean values of NA, NV and N/C." | 1.33 | Melatonin protects against lead-induced hepatic and renal toxicity in male rats. ( Abdel-Rahman, GH; El-Sokkary, GH; Kamel, ES, 2005) |
| "In animals with toxic hepatitis melatonin treatment decreased glutathione concentration and enzyme activities, which was probably associated with inhibition of free radical oxidation under the influence of this hormone." | 1.33 | Glutathione system and activity of NADPH-generating enzymes in the liver of intact rats and animals with toxic hepatitis receiving melatonin. ( Pashkov, AN; Popov, SS; Rakhmanova, TI; Semenikhina, AV, 2005) |
| "Treatment with melatonin (3 mg/kg/daily, i." | 1.32 | Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats. ( Aeed, H; Avinoach, I; Avni, Y; Bruck, R; Hochman, A; Matas, Z; Shahmurov, M; Shirin, H; Weizman, N; Zozulya, G, 2004) |
| "Melatonin has been recently introduced as an oncostatic agent, especially for hormone-dependent tumors." | 1.31 | Response in DNA ploidy of hepatocytes to tamoxifen and/or melatonin in vivo. ( Deniz, G; Gürdöl, F; Ozden, T; Süzme, R, 2001) |
| "Treatment with melatonin completely reversed this effect." | 1.29 | Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats. ( Attia, AM; Burgos, A; Hara, M; Melchiorri, D; Nistico, G; Reiter, RJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (5.66) | 18.2507 |
| 2000's | 16 (30.19) | 29.6817 |
| 2010's | 25 (47.17) | 24.3611 |
| 2020's | 9 (16.98) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Khatab, LA | 1 |
| Abdel-Raheem, IT | 1 |
| Ghoneim, AI | 1 |
| Abdraboh, ME | 1 |
| El-Missiry, MA | 1 |
| Othman, AI | 1 |
| Taha, AN | 1 |
| Elhamed, DSA | 1 |
| Amer, ME | 1 |
| Ozturk, I | 1 |
| Elbe, H | 2 |
| Bicer, Y | 1 |
| Karayakali, M | 1 |
| Onal, MO | 1 |
| Altinoz, E | 1 |
| Wang, SC | 1 |
| Huang, YC | 1 |
| Hsiao, CC | 1 |
| Sheen, JM | 1 |
| Huang, LT | 1 |
| Lo, WS | 1 |
| Hsieh, HY | 1 |
| Chen, YC | 1 |
| Oztopuz, O | 1 |
| Turkon, H | 1 |
| Buyuk, B | 1 |
| Coskun, O | 1 |
| Sehitoglu, MH | 1 |
| Ovali, MA | 1 |
| Uzun, M | 1 |
| Sayan, M | 1 |
| Karabulut, D | 1 |
| Özdamar, S | 1 |
| Barangi, S | 1 |
| Mehri, S | 1 |
| Moosavi, Z | 1 |
| Hayesd, AW | 1 |
| Reiter, RJ | 5 |
| Cardinali, DP | 1 |
| Karimi, G | 1 |
| Ullah, U | 1 |
| Badshah, H | 1 |
| Malik, Z | 1 |
| Uddin, Z | 1 |
| Alam, M | 1 |
| Sarwar, S | 1 |
| Aman, A | 1 |
| Khan, AU | 1 |
| Shah, FA | 1 |
| Liu, L | 1 |
| Zhang, L | 3 |
| Li, L | 1 |
| Chen, M | 2 |
| Wang, Z | 1 |
| Shen, Y | 1 |
| Huang, J | 1 |
| Tang, L | 1 |
| Song, C | 1 |
| Zhao, J | 1 |
| Fu, B | 1 |
| Li, D | 1 |
| Mao, T | 1 |
| Peng, W | 1 |
| Wu, H | 1 |
| Zhang, Y | 2 |
| Mortezaee, K | 1 |
| Khanlarkhani, N | 1 |
| Fang, J | 1 |
| Yan, Y | 1 |
| Teng, X | 1 |
| Wen, X | 1 |
| Li, N | 1 |
| Peng, S | 1 |
| Liu, W | 2 |
| Donadeu, FX | 1 |
| Zhao, S | 1 |
| Hua, J | 1 |
| Popov, SS | 3 |
| Pashkov, AN | 3 |
| Zoloedov, VI | 2 |
| Shvedov, GI | 2 |
| Sharma, S | 1 |
| Rana, SV | 1 |
| Shokrzadeh, M | 1 |
| Ahmadi, A | 1 |
| Naghshvar, F | 1 |
| Chabra, A | 1 |
| Jafarinejhad, M | 1 |
| Guo, P | 1 |
| Pi, H | 1 |
| Xu, S | 1 |
| Li, Y | 2 |
| Li, M | 1 |
| Cao, Z | 2 |
| Tian, L | 1 |
| Xie, J | 1 |
| Li, R | 1 |
| He, M | 2 |
| Lu, Y | 2 |
| Liu, C | 1 |
| Duan, W | 1 |
| Yu, Z | 2 |
| Zhou, Z | 2 |
| Akbulut, S | 1 |
| Eris, C | 1 |
| Dogan, Z | 1 |
| Toprak, G | 1 |
| Yalcin, E | 1 |
| Otan, E | 1 |
| Turkoz, Y | 1 |
| Allagui, MS | 1 |
| Hachani, R | 1 |
| Saidi, S | 1 |
| Feriani, A | 1 |
| Murat, JC | 1 |
| Kacem, K | 1 |
| El feki, A | 1 |
| Esteban-Zubero, E | 1 |
| Alatorre-Jiménez, MA | 1 |
| López-Pingarrón, L | 2 |
| Reyes-Gonzales, MC | 1 |
| Almeida-Souza, P | 1 |
| Cantín-Golet, A | 1 |
| Ruiz-Ruiz, FJ | 1 |
| Tan, DX | 1 |
| García, JJ | 2 |
| Taghizadieh, M | 1 |
| Hajipour, B | 1 |
| Asl N, A | 1 |
| Khodadadi, A | 1 |
| Somi, MH | 1 |
| Banei, M | 1 |
| Wei, Z | 1 |
| Wang, J | 1 |
| He, X | 1 |
| Huang, H | 1 |
| Zhang, J | 1 |
| Yang, Z | 1 |
| Fang, Y | 1 |
| Tan, D | 1 |
| Du, C | 1 |
| Ma, Q | 1 |
| Yu, J | 1 |
| Zhou, C | 1 |
| Pei, L | 1 |
| Ran, H | 1 |
| Jung, KH | 1 |
| Hong, SW | 1 |
| Zheng, HM | 1 |
| Lee, DH | 1 |
| Hong, SS | 1 |
| Kurus, M | 1 |
| Esrefoglu, M | 1 |
| Sogutlu, G | 1 |
| Atasever, A | 1 |
| El-Sokkary, GH | 2 |
| Nafady, AA | 1 |
| Shabash, EH | 1 |
| Shaker, ME | 1 |
| Houssen, ME | 1 |
| Abo-Hashem, EM | 1 |
| Ibrahim, TM | 1 |
| Aranda, M | 1 |
| Albendea, CD | 1 |
| Lostalé, F | 1 |
| Fuentes-Broto, L | 1 |
| Martínez-Ballarín, E | 1 |
| Pérez-Castejón, MC | 1 |
| Aydin, M | 1 |
| Oktar, S | 1 |
| Ozkan, OV | 1 |
| Alçin, E | 1 |
| Oztürk, OH | 1 |
| Nacar, A | 1 |
| Mishra, A | 1 |
| Paul, S | 1 |
| Swarnakar, S | 1 |
| Mercan, S | 1 |
| Eren, B | 1 |
| Koksal, M | 1 |
| Kurcer, Z | 1 |
| Erdogan, D | 1 |
| Iraz, M | 1 |
| Tas, M | 1 |
| Eren, MA | 1 |
| Aydogan, T | 1 |
| Ulas, T | 1 |
| Shul'gin, KK | 1 |
| Ali, SA | 1 |
| Aly, HF | 1 |
| Faddah, LM | 1 |
| Zaidi, ZF | 1 |
| El-Gibaly, I | 1 |
| Meki, AM | 1 |
| Abdel-Ghaffar, SK | 1 |
| Süzme, R | 1 |
| Gürdöl, F | 1 |
| Deniz, G | 1 |
| Ozden, T | 1 |
| Bruck, R | 1 |
| Aeed, H | 1 |
| Avni, Y | 1 |
| Shirin, H | 1 |
| Matas, Z | 1 |
| Shahmurov, M | 1 |
| Avinoach, I | 1 |
| Zozulya, G | 1 |
| Weizman, N | 1 |
| Hochman, A | 1 |
| Túnez, I | 1 |
| Muñoz, MC | 1 |
| Villavicencio, MA | 1 |
| Medina, FJ | 1 |
| de Prado, EP | 1 |
| Espejo, I | 1 |
| Barcos, M | 1 |
| Salcedo, M | 1 |
| Feijóo, M | 1 |
| Montilla, P | 1 |
| Rezzani, R | 1 |
| Buffoli, B | 1 |
| Rodella, L | 1 |
| Stacchiotti, A | 1 |
| Bianchi, R | 1 |
| Abdel-Rahman, GH | 1 |
| Kamel, ES | 1 |
| Semenikhina, AV | 1 |
| Rakhmanova, TI | 1 |
| Kanno, S | 1 |
| Tomizawa, A | 1 |
| Hiura, T | 1 |
| Osanai, Y | 1 |
| Kakuta, M | 1 |
| Kitajima, Y | 1 |
| Koiwai, K | 1 |
| Ohtake, T | 1 |
| Ujibe, M | 1 |
| Ishikawa, M | 1 |
| Noyan, T | 1 |
| Kömüroğlu, U | 1 |
| Bayram, I | 1 |
| Sekeroğlu, MR | 1 |
| Sulaiman, AA | 1 |
| Al-Shawi, NN | 1 |
| Jwaied, AH | 1 |
| Mahmood, DM | 1 |
| Hussain, SA | 1 |
| Wang, H | 1 |
| Xu, DX | 1 |
| Lv, JW | 1 |
| Ning, H | 1 |
| Wei, W | 1 |
| Melchiorri, D | 2 |
| Attia, AM | 1 |
| Hara, M | 1 |
| Burgos, A | 1 |
| Nistico, G | 1 |
| Sewerynek, E | 1 |
| Ortiz, GG | 1 |
| Lewinski, A | 1 |
| Cuzzocrea, S | 1 |
| Zingarelli, B | 1 |
| Costantino, G | 1 |
| Caputi, AP | 1 |
| Ohta, Y | 1 |
| Kongo, M | 1 |
| Sasaki, E | 1 |
| Nishida, K | 1 |
| Ishiguro, I | 1 |
2 reviews available for melatonin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Melatonin application in targeting oxidative-induced liver injuries: A review.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Humans; Li | 2018 |
Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review.
Topics: Aflatoxins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hum | 2016 |
1 trial available for melatonin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
[The use of melatonin in combined therapy of drug-induced hepatitis].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Male | 2013 |
50 other studies available for melatonin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Protective effects of melatonin and L-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Carniti | 2022 |
Constant light exposure and/or pinealectomy increases susceptibility to trichloroethylene-induced hepatotoxicity and liver cancer in male mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Neoplasms; Male; Melatonin; Mice; Pine | 2022 |
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation.
Topics: Acrylamide; Animals; Antioxidants; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury | 2023 |
Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling.
Topics: Animals; Chemical and Drug Induced Liver Injury; Melatonin; Methotrexate; Phosphatidylinositol 3-Kin | 2023 |
Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Peroxidase; | 2020 |
Assessment of the protective and therapeutic effect of melatonin against thioacetamide-induced acute liver damage.
Topics: Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2020 |
Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; | 2020 |
Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats.
Topics: Animals; Biomarkers; Celecoxib; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; E | 2020 |
Sleep deprivation aggravated lipopolysaccharide/D-galactosamine-induced acute liver injury by suppressing melatonin production.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caspases; Chemical and Drug Induced Live | 2020 |
Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway.
Topics: Alanine Transaminase; Antioxidants; Aspartate Aminotransferases; Cell Line; Cell Survival; Chemical | 2017 |
Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress.
Topics: Adipose Tissue; Animals; Cell Proliferation; Cells, Cultured; Cellular Senescence; Chemical and Drug | 2018 |
Melatonin improves liver function in benzene-treated rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Benzene; Bilirubin; Chemic | 2013 |
Prophylactic efficacy of melatonin on cyclophosphamide-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Lipid Peroxidation; | 2014 |
Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro.
Topics: Cadmium Chloride; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, | 2014 |
Effects of antioxidant agents against cyclosporine-induced hepatotoxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Allopurinol; Animals; Antioxidants; Aspartate Aminotrans | 2015 |
Pleiotropic protective roles of melatonin against aluminium-induced toxicity in rats.
Topics: Aluminum; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, | 2015 |
Combination effect of melatonin and dexamethasone on liver ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Dexamethasone; Male; Melatonin; Protecti | 2016 |
Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway.
Topics: Animals; Arsenic Trioxide; Arsenicals; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2017 |
Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome.
Topics: Animals; Cadmium; Carrier Proteins; Cell Death; Chemical and Drug Induced Liver Injury; Gene Express | 2017 |
Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Down-Regulation; Glutathione P | 2009 |
Melatonin prevents cyclosporine-induced hepatotoxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Disease Models, Animal; Free Radical | 2009 |
Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat.
Topics: Animals; Antioxidants; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Cytoplasm; Environm | 2010 |
Comparison of vitamin E, L-carnitine and melatonin in ameliorating carbon tetrachloride and diabetes induced hepatic oxidative stress.
Topics: Animals; Antioxidants; Blood Glucose; Carbon Tetrachloride Poisoning; Carnitine; Chemical and Drug I | 2009 |
In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline.
Topics: Animals; Carbolines; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 2010 |
Letrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatonin.
Topics: Animals; Antioxidants; Aromatase Inhibitors; Chemical and Drug Induced Liver Injury; Female; Letrozo | 2011 |
Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical a | 2011 |
Protective role of melatonin supplementation against nicotine-induced liver damage in mouse.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Melatonin; Mice; Nicotine | 2013 |
Effect of melatonin and n-acetylcysteine on hepatic injury in rat induced by methanol intoxication: a comparative study.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Ani | 2012 |
[Effect of combined therapy with melaxen on lipid peroxidation rate and citrate content in blood serum of patients with drug-induced hepatitis diagnosis].
Topics: Aconitate Hydratase; Adult; Aged; Antibiotics, Antitubercular; Antioxidants; Chemical and Drug Induc | 2012 |
Dietary supplementation of some antioxidants against hypoxia.
Topics: Animals; Antioxidants; Arginine; Chemical and Drug Induced Liver Injury; Cytoprotection; Dietary Sup | 2012 |
Problems with dietary supplements.
Topics: Chemical and Drug Induced Liver Injury; Dietary Supplements; Echinacea; Glucosamine; Herbal Medicine | 2002 |
Novel B melatonin-loaded chitosan microcapsules: in vitro characterization and antiapoptosis efficacy for aflatoxin B1-induced apoptosis in rat liver.
Topics: Administration, Oral; Aflatoxin B1; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Live | 2003 |
Response in DNA ploidy of hepatocytes to tamoxifen and/or melatonin in vivo.
Topics: Aneuploidy; Animals; Antineoplastic Agents, Hormonal; Antioxidants; Chemical and Drug Induced Liver | 2001 |
Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats.
Topics: Ammonia; Animals; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Liver; Liver Dise | 2004 |
Hepato- and neurotoxicity induced by thioacetamide: protective effects of melatonin and dimethylsulfoxide.
Topics: Alanine Transaminase; Ammonia; Animals; Blood Urea Nitrogen; Brain; Catalase; Chemical and Drug Indu | 2005 |
Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver.
Topics: Animals; Antioxidants; Chaperonin 60; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathi | 2005 |
Melatonin protects against lead-induced hepatic and renal toxicity in male rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Histocytochemistry; Karyometry; Kidney | 2005 |
Glutathione system and activity of NADPH-generating enzymes in the liver of intact rats and animals with toxic hepatitis receiving melatonin.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glucosephosphate Dehydrogenase; Glutathione; Glutat | 2005 |
Melatonin protects on toxicity by acetaminophen but not on pharmacological effects in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Body Temperature; Cell Survival; Che | 2006 |
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In | 2006 |
Protective effect of melatonin against chlorpromazine-induced liver disease in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chlorpromazine; Disease Models, Anima | 2006 |
Melatonin attenuates lipopolysaccharide (LPS)-induced apoptotic liver damage in D-galactosamine-sensitized mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liver I | 2007 |
Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats.
Topics: Aldehydes; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glutat | 1995 |
Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Escherichia coli; Glutathione; Lipid | 1995 |
Protective effect of melatonin in a non-septic shock model induced by zymosan in the rat.
Topics: Acute Disease; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemotaxis, Leukocyte; | 1998 |
Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; In | 2000 |