melatonin has been researched along with Acute Disease in 81 studies
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this randomized control trial, a total of 59 AOPP patients with subsequent delirium were randomly divided into two groups, the melatonin group (n=29) and the placebo-controlled group (n=30)." | 9.27 | Observation and analysis of clinical efficacy of melatonin on AOPP-induced delirium patients. ( Du, GH; Li, ZF; Pan, YY; Zhang, Y; Zhao, LB; Zhen, GD; Zhou, SZ, 2018) |
| ", melatonin) may have a role in the pathogenesis of delirium." | 9.15 | Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. ( Al-Aama, T; Brymer, C; Dasgupta, M; Esbaugh, J; Gutmanis, I; Woolmore-Goodwin, SM, 2011) |
| "The aim of this study was to investigate the possible therapeutic impacts of two pineal hormones, melatonin and 5-methoxytryptophol (5-MTX), in a rat model of acute pulpitis by analyzing biochemical and histopathological parameters." | 8.02 | Anti-Inflammatory Effects of Melatonin and 5-Methoxytryptophol on Lipopolysaccharide-Induced Acute Pulpitis in Rats. ( Aksoy, U; Kermeoğlu, F; Özkayalar, H; Savtekin, G; Sayıner, S; Sebai, A; Şehirli, AÖ, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 8.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " This study investigated the potential effects of luzindole on LPS/d-galactosamine (d-GalN)-induced acute hepatitis." | 7.96 | Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice. ( Huang, J; Li, L; Luo, Y; Shen, Y; Tang, L; Yang, Y; Zhang, L, 2020) |
| "The aim of the present study was to investigate the protective mechanism underlying of melatonin in severe acute pancreatitis (SAP)." | 7.88 | Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Shao, B; Wu, J; Zhang, Y; Zhao, Q, 2018) |
| "The objective of this study is to explore the effect of melatonin on endoplasmic reticulum stress in acute pancreatitis (AP) and the molecular mechanism." | 7.88 | Melatonin Attenuates Endoplasmic Reticulum Stress in Acute Pancreatitis. ( Chen, Q; Huang, J; Li, J; Sun, Y; Tang, X; Wu, J; Zhao, Q, 2018) |
| "Melatonin protects the pancreas from inflammation and free radical damage but the effect of the melatonin metabolite: N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) on acute pancreatitis is unknown." | 7.83 | Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies. ( Bonior, J; Czech, U; Goralska, M; Jaworek, J; Kot, M; Pierzchalski, P; Reiter, RJ; Szklarczyk, J; Tomaszewska, R, 2016) |
| "Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress and increase of the activities of antioxidant enzymes in cerulein-induced acute pancreatitis." | 7.80 | Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. ( Carrasco, C; Pariente, JA; Rodriguez, AB, 2014) |
| "The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers." | 7.80 | [Results of dynamic assessment of melatonin receptor expression in lymphocytes in patients with acute mild and severe pancreatitis]. ( Gorchakova, MV; Osmanov, ZKh; Semenov, DIu; Shapkina, LG; Sokolov, AV; Tonoian, AG, 2014) |
| "The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis." | 7.79 | Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis. ( Carrasco, C; Holguín-Arévalo, MS; Marchena, AM; Martín-Partido, G; Paredes, SD; Pariente, JA; Rodríguez, AB, 2013) |
| "To assess the value of plasma melatonin in predicting acute pancreatitis when combined with the acute physiology and chronic health evaluation II (APACHEII) and bedside index for severity in acute pancreatitis (BISAP) scoring systems." | 7.79 | Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. ( Chen, MJ; Dong, LM; Jin, Y; Lin, CJ; Wu, JS; Zhou, Q, 2013) |
| "Melatonin protects rats against acute pancreatitis-associated lung injury, probably through the upregulation of IL-22 and Th22, which increases the innate immunity of tissue cells and enhances their regeneration." | 7.78 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22. ( Chen, MJ; Huai, JP; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Ye, XH, 2012) |
| "Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects." | 7.77 | Protective role of endogenous melatonin in the early course of human acute pancreatitis. ( Belyaev, O; Bolik, B; Herzog, T; Müller, CA; Munding, J; Uhl, W; Vosschulte, A, 2011) |
| "Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis." | 7.76 | Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. ( Bugdayci, G; Buyukasik, O; Col, C; Dinler, K; Hasdemir, O, 2010) |
| "The aim of this study was to address the protective effects of exogenous melatonin injections intraperitoneally on the histopathological changes in a model of obstructive acute pancreatitis." | 7.76 | Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation. ( Büyükaşik, O; Çöl, C; Dınler, K; Firat, T; Hasdemır, O; Kükner, A, 2010) |
| "The association of nocturnal serum melatonin levels was investigated in acute multiple sclerosis (MS) patients with major depression (MD)." | 7.74 | The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis. ( Akpinar, Z; Gökbel, H; Okudan, N; Tokgöz, S; Uğuz, F; Yilmaz, G, 2008) |
| "Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis." | 7.73 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats. ( Hegyi, P; Jarmay, K; Kaszaki, J; Letoha, T; Lonovics, J; Papai, G; Rakonczay, Z; Reiter, RJ; Sari, R; Szabolcs, A; Takacs, T; Varga, I, 2006) |
| "This study evaluated the expression of neutrophil apoptosis and the effects of melatonin at different concentrations on delayed neutrophil apoptosis in different severities of acute pancreatitis in patients." | 7.73 | Delayed neutrophil apoptosis attenuated by melatonin in human acute pancreatitis. ( Chen, HM; Chen, JC; Chen, MF; Chiu, DF; Hsu, JT; Ng, CJ, 2005) |
| "To investigate the role of oxidative injury in pancreatitis-induced hepatic damage and the effect of antioxidant agents such as melatonin, ascorbic acid and N-acetyl cysteine on caerulein-induced pancreatitis and associated liver injury in rats." | 7.73 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats. ( Ates, B; Batçioğlu, K; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "The results indicate the existence of an imbalance in tryptophan metabolites in preterm infants and those with fetal distress, blunting the normal diurnal/nocturnal rhythm of both melatonin and kynurenines." | 7.70 | Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress. ( Acuña-Castroviejo, D; Macías, M; Martín-Medina, E; Molina-Carballo, A; Muñoz-Hoyos, A; Narbona-López, E; Rodríguez-Cabezas, T; Valenzuela-Ruiz, A, 1998) |
| "Since oxygen free radicals and lipid peroxidation have been implicated in the pathogenesis of an early stage of acute pancreatitis, we examined whether melatonin, a recently discovered free-radical scavenger, could attenuate pancreatic injury in Sprague-Dawley rats with cerulein-induced pancreatitis." | 7.70 | Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. ( Cabrera, J; Kim, SJ; Manchester, LC; Mayo, JC; Qi, W; Reiter, RJ; Sainz, RM; Tan, DX, 1999) |
| "Single intraperitoneal injection of melatonin in a dose of 1 mg/kg prevented accumulation of cGMP and intensification of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypobaric hypoxia (12,000 m)." | 7.70 | Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia. ( Pishak, VP; Zamorskii, II, 2000) |
| "In order to assess the existence of a rhythmic secretion of melatonin (aMT) in newborns and whether this rhythm is affected by neonatal stress, we studied 112 newborns classified in three groups: normal babies delivered at term, preterm infants born before the 38th week, and babies with fetal distress." | 7.68 | Melatonin concentration in the umbilical artery and vein in human preterm and term neonates and neonates with acute fetal distress. ( Acuña-Castroviejo, D; Martinez-Sempere, JJ; Molina-Carballo, A; Muñoz-Hoyos, A; Rodriguez-Cabezas, T; Ruiz-Cosano, C, 1992) |
| "The diurnal rhythm of plasma melatonin was studied in 46 Chinese patients with acute cerebral hemorrhage." | 7.68 | Acute cerebral hemorrhage changes the nocturnal surge of plasma melatonin in humans. ( Chang, B; Jiang, DH; Li, Y; Pang, SF; Xie, BL, 1990) |
| "Acute pancreatitis is a disease, which could be manifested as either a mild edematous form or a more severe necrotizing pancreatitis which has a poor prognosis." | 6.50 | The role of melatonin in pancreatic protection: could melatonin be used in the treatment of acute pancreatitis? ( Bonior, J; Jaworek, A; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porbka, K; Szklarczyk, J, 2014) |
| "Whether acute pancreatitis develops as the severe type or resolves depends on the intensity of the inflammatory process which is counteracted by the recruitment of innate defense mechanisms." | 6.50 | Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin. ( Jaworek, J; Konturek, SJ, 2014) |
| "Melatonin has been shown to possess both in vitro and in vivo important antioxidant activities as well as to inhibit the activation of poly (ADP ribose) synthetase." | 6.41 | Pharmacological actions of melatonin in acute and chronic inflammation. ( Cuzzocrea, S; Reiter, RJ, 2002) |
| "Myocardial ischemia was induced by 40-min coronary occlusion in 25 anesthetized pigs." | 5.56 | Melatonin Prevents Early but Not Delayed Ventricular Fibrillation in the Experimental Porcine Model of Acute Ischemia. ( Azarov, JE; Bernikova, OG; Demidova, MM; Khramova, DS; Mikhaleva, NJ; Ovechkin, AO; Platonov, PG; Tsvetkova, AS, 2020) |
| "Pre‑treatment with melatonin was further used to identify the potential anti‑inflammatory mechanisms in AP." | 5.48 | Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis. ( Che, Q; Huang, J; Jin, Y; Li, J; Sun, Y; Wu, J; Yu, H; Zhang, H; Zhao, Q, 2018) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 5.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats." | 5.35 | The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. ( Bugdayci, G; Cöl, C; Dinler, K; Hasdemir, AO, 2009) |
| "Acute pancreatitis was induced by two i." | 5.33 | Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. ( Ateş, B; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "Acute pancreatitis was induced by subcutaneous infusion of caerulein (5 microg/kg-h x 5 h)." | 5.32 | Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action. ( Bonior, J; Czupryna, A; Jaworek, J; Konturek, SJ; Kot, M; Leja-Szpak, A; Nawrot, K; Palonek, M; Pawlik, WW; Stachura, J; Tomaszewska, R, 2004) |
| "Furthermore, carrageenan-induced pleurisy caused a suppression of macrophage mitochondrial respiration, DNA strand breakage, activation of PARS, and reduction of cellular levels of NAD+." | 5.31 | Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. ( Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Fulia, F; Serraino, I, 2001) |
| "Melatonin is a hormone that is influenced by the circadian environmental variations of dark-light and is a modulator of the immune system." | 5.30 | Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. ( Delgado, F; Guerrero, JM; Lopez-Gonzalez, MA; Sanchez, B, 1998) |
| "In this randomized control trial, a total of 59 AOPP patients with subsequent delirium were randomly divided into two groups, the melatonin group (n=29) and the placebo-controlled group (n=30)." | 5.27 | Observation and analysis of clinical efficacy of melatonin on AOPP-induced delirium patients. ( Du, GH; Li, ZF; Pan, YY; Zhang, Y; Zhao, LB; Zhen, GD; Zhou, SZ, 2018) |
| ", melatonin) may have a role in the pathogenesis of delirium." | 5.15 | Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. ( Al-Aama, T; Brymer, C; Dasgupta, M; Esbaugh, J; Gutmanis, I; Woolmore-Goodwin, SM, 2011) |
| "The aim of this study was to investigate the possible therapeutic impacts of two pineal hormones, melatonin and 5-methoxytryptophol (5-MTX), in a rat model of acute pulpitis by analyzing biochemical and histopathological parameters." | 4.02 | Anti-Inflammatory Effects of Melatonin and 5-Methoxytryptophol on Lipopolysaccharide-Induced Acute Pulpitis in Rats. ( Aksoy, U; Kermeoğlu, F; Özkayalar, H; Savtekin, G; Sayıner, S; Sebai, A; Şehirli, AÖ, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 4.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " This study investigated the potential effects of luzindole on LPS/d-galactosamine (d-GalN)-induced acute hepatitis." | 3.96 | Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice. ( Huang, J; Li, L; Luo, Y; Shen, Y; Tang, L; Yang, Y; Zhang, L, 2020) |
| "The objective of this study is to explore the effect of melatonin on endoplasmic reticulum stress in acute pancreatitis (AP) and the molecular mechanism." | 3.88 | Melatonin Attenuates Endoplasmic Reticulum Stress in Acute Pancreatitis. ( Chen, Q; Huang, J; Li, J; Sun, Y; Tang, X; Wu, J; Zhao, Q, 2018) |
| "To evaluate m-RNA expressions of SERCA2 and NCX1 in acute pancreatitis induced by sodium taurocholate in Wistar rats pre-treated with melatonin and/or TD." | 3.88 | THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE. ( Chaib, E; Coelho, AM; Cunha, JEM; D'Albuquerque, LAC; Kubrusly, MS; Lima, MA; Nader, HB; Sanpietri, SN; Tersariol, ILS; Vasques, ER, 2018) |
| "The aim of the present study was to investigate the protective mechanism underlying of melatonin in severe acute pancreatitis (SAP)." | 3.88 | Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Shao, B; Wu, J; Zhang, Y; Zhao, Q, 2018) |
| "Melatonin protects the pancreas from inflammation and free radical damage but the effect of the melatonin metabolite: N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) on acute pancreatitis is unknown." | 3.83 | Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies. ( Bonior, J; Czech, U; Goralska, M; Jaworek, J; Kot, M; Pierzchalski, P; Reiter, RJ; Szklarczyk, J; Tomaszewska, R, 2016) |
| "Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress and increase of the activities of antioxidant enzymes in cerulein-induced acute pancreatitis." | 3.80 | Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. ( Carrasco, C; Pariente, JA; Rodriguez, AB, 2014) |
| "The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers." | 3.80 | [Results of dynamic assessment of melatonin receptor expression in lymphocytes in patients with acute mild and severe pancreatitis]. ( Gorchakova, MV; Osmanov, ZKh; Semenov, DIu; Shapkina, LG; Sokolov, AV; Tonoian, AG, 2014) |
| "To assess the value of plasma melatonin in predicting acute pancreatitis when combined with the acute physiology and chronic health evaluation II (APACHEII) and bedside index for severity in acute pancreatitis (BISAP) scoring systems." | 3.79 | Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. ( Chen, MJ; Dong, LM; Jin, Y; Lin, CJ; Wu, JS; Zhou, Q, 2013) |
| "The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis." | 3.79 | Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis. ( Carrasco, C; Holguín-Arévalo, MS; Marchena, AM; Martín-Partido, G; Paredes, SD; Pariente, JA; Rodríguez, AB, 2013) |
| "Melatonin protects rats against acute pancreatitis-associated lung injury, probably through the upregulation of IL-22 and Th22, which increases the innate immunity of tissue cells and enhances their regeneration." | 3.78 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22. ( Chen, MJ; Huai, JP; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Ye, XH, 2012) |
| "Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects." | 3.77 | Protective role of endogenous melatonin in the early course of human acute pancreatitis. ( Belyaev, O; Bolik, B; Herzog, T; Müller, CA; Munding, J; Uhl, W; Vosschulte, A, 2011) |
| "The aim of this study was to address the protective effects of exogenous melatonin injections intraperitoneally on the histopathological changes in a model of obstructive acute pancreatitis." | 3.76 | Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation. ( Büyükaşik, O; Çöl, C; Dınler, K; Firat, T; Hasdemır, O; Kükner, A, 2010) |
| "Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis." | 3.76 | Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. ( Bugdayci, G; Buyukasik, O; Col, C; Dinler, K; Hasdemir, O, 2010) |
| "The association of nocturnal serum melatonin levels was investigated in acute multiple sclerosis (MS) patients with major depression (MD)." | 3.74 | The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis. ( Akpinar, Z; Gökbel, H; Okudan, N; Tokgöz, S; Uğuz, F; Yilmaz, G, 2008) |
| "Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis." | 3.73 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats. ( Hegyi, P; Jarmay, K; Kaszaki, J; Letoha, T; Lonovics, J; Papai, G; Rakonczay, Z; Reiter, RJ; Sari, R; Szabolcs, A; Takacs, T; Varga, I, 2006) |
| "This study evaluated the expression of neutrophil apoptosis and the effects of melatonin at different concentrations on delayed neutrophil apoptosis in different severities of acute pancreatitis in patients." | 3.73 | Delayed neutrophil apoptosis attenuated by melatonin in human acute pancreatitis. ( Chen, HM; Chen, JC; Chen, MF; Chiu, DF; Hsu, JT; Ng, CJ, 2005) |
| "To investigate the role of oxidative injury in pancreatitis-induced hepatic damage and the effect of antioxidant agents such as melatonin, ascorbic acid and N-acetyl cysteine on caerulein-induced pancreatitis and associated liver injury in rats." | 3.73 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats. ( Ates, B; Batçioğlu, K; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "The aim of the present study was to investigate the protective effect of the pineal hormone melatonin in a model of acute local inflammation (carrageenan-induced paw oedema)." | 3.71 | Protective effect of melatonin in carrageenan-induced acute local inflammation. ( Akpinar, E; Bilici, D; Kiziltunç, A, 2002) |
| "Single intraperitoneal injection of melatonin in a dose of 1 mg/kg prevented accumulation of cGMP and intensification of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypobaric hypoxia (12,000 m)." | 3.70 | Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia. ( Pishak, VP; Zamorskii, II, 2000) |
| "Since oxygen free radicals and lipid peroxidation have been implicated in the pathogenesis of an early stage of acute pancreatitis, we examined whether melatonin, a recently discovered free-radical scavenger, could attenuate pancreatic injury in Sprague-Dawley rats with cerulein-induced pancreatitis." | 3.70 | Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. ( Cabrera, J; Kim, SJ; Manchester, LC; Mayo, JC; Qi, W; Reiter, RJ; Sainz, RM; Tan, DX, 1999) |
| "The results indicate the existence of an imbalance in tryptophan metabolites in preterm infants and those with fetal distress, blunting the normal diurnal/nocturnal rhythm of both melatonin and kynurenines." | 3.70 | Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress. ( Acuña-Castroviejo, D; Macías, M; Martín-Medina, E; Molina-Carballo, A; Muñoz-Hoyos, A; Narbona-López, E; Rodríguez-Cabezas, T; Valenzuela-Ruiz, A, 1998) |
| "In order to assess the existence of a rhythmic secretion of melatonin (aMT) in newborns and whether this rhythm is affected by neonatal stress, we studied 112 newborns classified in three groups: normal babies delivered at term, preterm infants born before the 38th week, and babies with fetal distress." | 3.68 | Melatonin concentration in the umbilical artery and vein in human preterm and term neonates and neonates with acute fetal distress. ( Acuña-Castroviejo, D; Martinez-Sempere, JJ; Molina-Carballo, A; Muñoz-Hoyos, A; Rodriguez-Cabezas, T; Ruiz-Cosano, C, 1992) |
| "The diurnal rhythm of plasma melatonin was studied in 46 Chinese patients with acute cerebral hemorrhage." | 3.68 | Acute cerebral hemorrhage changes the nocturnal surge of plasma melatonin in humans. ( Chang, B; Jiang, DH; Li, Y; Pang, SF; Xie, BL, 1990) |
| "As an acute treatment for pediatric migraine, both low and high doses of melatonin were associated with pain reduction; however, study drop-out was high." | 2.94 | Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial. ( Allen, IE; Gelfand, AA; Greene, KA; Irwin, SL; Qubty, WF; Ross, AC, 2020) |
| "Acute pancreatitis is a disease, which could be manifested as either a mild edematous form or a more severe necrotizing pancreatitis which has a poor prognosis." | 2.50 | The role of melatonin in pancreatic protection: could melatonin be used in the treatment of acute pancreatitis? ( Bonior, J; Jaworek, A; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porbka, K; Szklarczyk, J, 2014) |
| "Whether acute pancreatitis develops as the severe type or resolves depends on the intensity of the inflammatory process which is counteracted by the recruitment of innate defense mechanisms." | 2.50 | Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin. ( Jaworek, J; Konturek, SJ, 2014) |
| "Melatonin has been shown to possess both in vitro and in vivo important antioxidant activities as well as to inhibit the activation of poly (ADP ribose) synthetase." | 2.41 | Pharmacological actions of melatonin in acute and chronic inflammation. ( Cuzzocrea, S; Reiter, RJ, 2002) |
| "Myocardial ischemia was induced by 40-min coronary occlusion in 25 anesthetized pigs." | 1.56 | Melatonin Prevents Early but Not Delayed Ventricular Fibrillation in the Experimental Porcine Model of Acute Ischemia. ( Azarov, JE; Bernikova, OG; Demidova, MM; Khramova, DS; Mikhaleva, NJ; Ovechkin, AO; Platonov, PG; Tsvetkova, AS, 2020) |
| "Melatonin is a multifunctional indolamine and has a cardioprotective role in a variety of cardiovascular processes via antioxidant, anti-inflammatory, antihypertensive, antithrombotic, and antilipemic effects." | 1.51 | Plasma levels of melatonin in dilated cardiomyopathy. ( Kobayashi, A; Kunii, H; Misaka, T; Nakazato, K; Oikawa, M; Sato, T; Sugimoto, K; Takeishi, Y; Yamaki, T; Yokokawa, T; Yoshihisa, A, 2019) |
| "Melatonin treatment activated MFN2-related mitochondrial fusion via suppressing Mst1-Hippo pathway, finally sustaining mitochondrial function and reducing reperfusion-mediated cerebral injury." | 1.51 | Effects of melatonin on acute brain reperfusion stress: role of Hippo signaling pathway and MFN2-related mitochondrial protection. ( Bi, C; Lan, S; Liu, J; Luo, X, 2019) |
| "Pre‑treatment with melatonin was further used to identify the potential anti‑inflammatory mechanisms in AP." | 1.48 | Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis. ( Che, Q; Huang, J; Jin, Y; Li, J; Sun, Y; Wu, J; Yu, H; Zhang, H; Zhao, Q, 2018) |
| "Among patients with migraine, 53% presented pain on the day of the urine samples collection." | 1.35 | Low urinary 6-sulphatoxymelatonin concentrations in acute migraine. ( Cipolla-Neto, J; de Souza Vieira, DS; Masruha, MR; Minett, TS; Peres, MF; Vilanova, LC; Zukerman, E, 2008) |
| "Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats." | 1.35 | The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. ( Bugdayci, G; Cöl, C; Dinler, K; Hasdemir, AO, 2009) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 1.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "The prognosis of acute pancreatitis (AP) depends upon the degree of pancreatic necrosis and the intensity of multisystem organ failure." | 1.35 | Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis. ( Eşrefoğlu, M; Gül, M; Turan, F, 2008) |
| "Acute pancreatitis was induced by two i." | 1.33 | Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. ( Ateş, B; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "In melatonin pretreated rats, the hypoxia-induced reduction of COX reactivity was obviously prevented and the augmentation of NOS/NADPH-d reactivity was successfully suppressed." | 1.33 | Melatonin restores the cytochrome oxidase reactivity in the nodose ganglia of acute hypoxic rats. ( Chang, HM; Lue, JH; Shieh, JY; Tseng, CY; Wei, IH; Wen, CY, 2005) |
| "Acute pancreatitis was induced by subcutaneous infusion of caerulein (5 microg/kg-h x 5 h)." | 1.32 | Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action. ( Bonior, J; Czupryna, A; Jaworek, J; Konturek, SJ; Kot, M; Leja-Szpak, A; Nawrot, K; Palonek, M; Pawlik, WW; Stachura, J; Tomaszewska, R, 2004) |
| "Melatonin was the most powerful agent, particularly at the fourth hour." | 1.32 | Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury. ( Akdemir, I; Gursu, F; Kaplan, M; Kilic, N; Ozveren, F; Tiftikci, M; Topsakal, C, 2003) |
| "Melatonin was administered twice (6." | 1.31 | Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats. ( Kondoh, T; Nishino, H; Torii, K; Uneyama, H, 2002) |
| "Furthermore, carrageenan-induced pleurisy caused a suppression of macrophage mitochondrial respiration, DNA strand breakage, activation of PARS, and reduction of cellular levels of NAD+." | 1.31 | Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. ( Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Fulia, F; Serraino, I, 2001) |
| "Acute hepatic porphyrias are risk factors for hepatocellular carcinoma." | 1.31 | Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors. ( Andant, C; Bogard, C; Deybach, JC; Faivre, J; Nordmann, Y; Puy, H; Soulé, JC, 2000) |
| "Melatonin is a hormone that is influenced by the circadian environmental variations of dark-light and is a modulator of the immune system." | 1.30 | Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. ( Delgado, F; Guerrero, JM; Lopez-Gonzalez, MA; Sanchez, B, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.47) | 18.7374 |
| 1990's | 13 (16.05) | 18.2507 |
| 2000's | 34 (41.98) | 29.6817 |
| 2010's | 26 (32.10) | 24.3611 |
| 2020's | 6 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, Y | 1 |
| Yang, Y | 1 |
| Shen, Y | 1 |
| Li, L | 1 |
| Huang, J | 3 |
| Tang, L | 1 |
| Zhang, L | 2 |
| Sayan, M | 1 |
| Karabulut, D | 1 |
| Özdamar, S | 1 |
| Gelfand, AA | 1 |
| Ross, AC | 1 |
| Irwin, SL | 1 |
| Greene, KA | 1 |
| Qubty, WF | 1 |
| Allen, IE | 1 |
| Tsvetkova, AS | 1 |
| Bernikova, OG | 1 |
| Mikhaleva, NJ | 1 |
| Khramova, DS | 1 |
| Ovechkin, AO | 1 |
| Demidova, MM | 1 |
| Platonov, PG | 1 |
| Azarov, JE | 1 |
| Kermeoğlu, F | 1 |
| Aksoy, U | 1 |
| Sebai, A | 1 |
| Savtekin, G | 1 |
| Özkayalar, H | 1 |
| Sayıner, S | 1 |
| Şehirli, AÖ | 1 |
| Xiao, WZ | 1 |
| Zhao, L | 1 |
| Cao, L | 1 |
| Zhu, XX | 1 |
| Zou, HJ | 1 |
| Chen, Y | 1 |
| Zhao, Q | 3 |
| Chen, Q | 2 |
| Zhang, Y | 2 |
| Shao, B | 1 |
| Jin, Y | 4 |
| Wu, J | 3 |
| Zhao, LB | 1 |
| Zhen, GD | 1 |
| Pan, YY | 1 |
| Du, GH | 1 |
| Zhou, SZ | 1 |
| Li, ZF | 1 |
| Tang, X | 1 |
| Li, J | 2 |
| Sun, Y | 2 |
| Vasques, ER | 1 |
| Cunha, JEM | 1 |
| Kubrusly, MS | 1 |
| Coelho, AM | 1 |
| Sanpietri, SN | 1 |
| Nader, HB | 1 |
| Tersariol, ILS | 1 |
| Lima, MA | 1 |
| Chaib, E | 1 |
| D'Albuquerque, LAC | 1 |
| Sopova, IY | 1 |
| Zamorskii, II | 2 |
| Zhang, H | 2 |
| Yu, H | 1 |
| Che, Q | 1 |
| Lan, S | 1 |
| Liu, J | 1 |
| Luo, X | 1 |
| Bi, C | 1 |
| Misaka, T | 1 |
| Yoshihisa, A | 1 |
| Yokokawa, T | 1 |
| Sato, T | 1 |
| Oikawa, M | 1 |
| Kobayashi, A | 1 |
| Yamaki, T | 1 |
| Sugimoto, K | 1 |
| Kunii, H | 1 |
| Nakazato, K | 1 |
| Takeishi, Y | 1 |
| Lin, CJ | 1 |
| Dong, LM | 1 |
| Chen, MJ | 2 |
| Zhou, Q | 1 |
| Wu, JS | 2 |
| Jaworek, J | 5 |
| Leja-Szpak, A | 3 |
| Kot, M | 4 |
| Jaworek, A | 1 |
| Nawrot-Porbka, K | 1 |
| Bonior, J | 4 |
| Szklarczyk, J | 3 |
| Carrasco, C | 2 |
| Marchena, AM | 1 |
| Holguín-Arévalo, MS | 1 |
| Martín-Partido, G | 1 |
| Rodríguez, AB | 2 |
| Paredes, SD | 1 |
| Pariente, JA | 2 |
| Semenov, DIu | 1 |
| Osmanov, ZKh | 1 |
| Tonoian, AG | 1 |
| Shapkina, LG | 1 |
| Sokolov, AV | 1 |
| Gorchakova, MV | 1 |
| Konturek, SJ | 8 |
| Pertsov, SS | 3 |
| Koplik, EV | 1 |
| Kalinichenko, LS | 1 |
| Alekseeva, IV | 1 |
| Targum, SD | 1 |
| Wedel, PC | 1 |
| Fava, M | 1 |
| Goralska, M | 1 |
| Pierzchalski, P | 1 |
| Reiter, RJ | 5 |
| Czech, U | 1 |
| Tomaszewska, R | 2 |
| Masruha, MR | 1 |
| de Souza Vieira, DS | 1 |
| Minett, TS | 1 |
| Cipolla-Neto, J | 1 |
| Zukerman, E | 1 |
| Vilanova, LC | 1 |
| Peres, MF | 1 |
| Konturek, PC | 5 |
| Celinski, K | 1 |
| Slomka, M | 1 |
| Cichoz-Lach, H | 1 |
| Burnat, G | 1 |
| Naegel, A | 1 |
| Bielanski, W | 3 |
| Konturek, JW | 1 |
| Akpinar, Z | 1 |
| Tokgöz, S | 1 |
| Gökbel, H | 1 |
| Okudan, N | 1 |
| Uğuz, F | 1 |
| Yilmaz, G | 1 |
| Vanelle, JM | 1 |
| Ar'eva, GT | 1 |
| Solov'ev, MM | 1 |
| Ar'ev, AL | 1 |
| Cöl, C | 3 |
| Dinler, K | 3 |
| Hasdemir, AO | 1 |
| Bugdayci, G | 2 |
| Ganguly, K | 1 |
| Swarnakar, S | 1 |
| Liu, Y | 1 |
| Zhang, X | 1 |
| Xie, Y | 1 |
| Zhao, W | 1 |
| Hasdemir, O | 2 |
| Buyukasik, O | 2 |
| Kamperis, K | 1 |
| Hagstroem, S | 1 |
| Radvanska, E | 1 |
| Rittig, S | 1 |
| Djurhuus, JC | 1 |
| Al-Aama, T | 1 |
| Brymer, C | 1 |
| Gutmanis, I | 1 |
| Woolmore-Goodwin, SM | 1 |
| Esbaugh, J | 1 |
| Dasgupta, M | 1 |
| Belyaev, O | 1 |
| Herzog, T | 1 |
| Munding, J | 1 |
| Bolik, B | 1 |
| Vosschulte, A | 1 |
| Uhl, W | 1 |
| Müller, CA | 1 |
| Firat, T | 1 |
| Kükner, A | 1 |
| Cheshchevik, VT | 1 |
| Lapshina, EA | 1 |
| Dremza, IK | 1 |
| Zabrodskaya, SV | 1 |
| Prokopchik, NI | 1 |
| Zavodnik, IB | 1 |
| Arushanian, ÉB | 1 |
| Huai, JP | 1 |
| Sun, XC | 1 |
| Ye, XH | 1 |
| Huang, ZM | 1 |
| Lowes, DA | 1 |
| Webster, NR | 1 |
| Murphy, MP | 1 |
| Galley, HF | 1 |
| Bilici, D | 1 |
| Akpinar, E | 1 |
| Kiziltunç, A | 1 |
| Kondoh, T | 1 |
| Uneyama, H | 1 |
| Nishino, H | 1 |
| Torii, K | 1 |
| Topsakal, C | 1 |
| Kilic, N | 1 |
| Ozveren, F | 1 |
| Akdemir, I | 1 |
| Kaplan, M | 1 |
| Tiftikci, M | 1 |
| Gursu, F | 1 |
| Nawrot, K | 1 |
| Palonek, M | 1 |
| Stachura, J | 2 |
| Czupryna, A | 1 |
| Pawlik, WW | 4 |
| Contuk, G | 1 |
| Ercan, F | 1 |
| Cetinel, S | 1 |
| Cikler, E | 1 |
| Sener, G | 1 |
| Domínguez Rodríguez, A | 1 |
| García González, MJ | 1 |
| Abreu González, P | 1 |
| Ferrer Hita, J | 1 |
| Chang, HM | 1 |
| Tseng, CY | 1 |
| Wei, IH | 1 |
| Lue, JH | 1 |
| Wen, CY | 1 |
| Shieh, JY | 1 |
| Chen, HM | 1 |
| Hsu, JT | 1 |
| Chen, JC | 1 |
| Ng, CJ | 1 |
| Chiu, DF | 1 |
| Chen, MF | 1 |
| Eşrefoğlu, M | 3 |
| Gül, M | 3 |
| Ateş, B | 2 |
| Selimoğlu, MA | 2 |
| BaHammam, A | 1 |
| Szabolcs, A | 1 |
| Letoha, T | 1 |
| Hegyi, P | 1 |
| Papai, G | 1 |
| Varga, I | 1 |
| Jarmay, K | 1 |
| Kaszaki, J | 1 |
| Sari, R | 1 |
| Rakonczay, Z | 1 |
| Lonovics, J | 1 |
| Takacs, T | 1 |
| Batçioğlu, K | 1 |
| Tugyan, K | 1 |
| Uysal, N | 1 |
| Ozdemir, D | 1 |
| Sonmez, U | 1 |
| Pekcetin, C | 1 |
| Erbil, G | 1 |
| Sonmez, A | 1 |
| Crisafulli, C | 1 |
| Mazzon, E | 1 |
| Muià, C | 1 |
| Bella, P | 1 |
| Esposito, E | 1 |
| Meli, R | 1 |
| Cuzzocrea, S | 4 |
| Ramírez-Zambrano, E | 1 |
| Zambrano, E | 1 |
| Rojas, G | 1 |
| Zambrano, M | 1 |
| Teneud, L | 1 |
| Zayachkivska, O | 1 |
| Havryluk, XO | 1 |
| Brzozowski, T | 4 |
| Sliwowski, Z | 2 |
| Pawlik, M | 2 |
| Cześnikiewicz-Guzik, M | 1 |
| Gzhegotsky, MR | 1 |
| Turan, F | 1 |
| Zwirska-Korczala, K | 1 |
| Kwiecien, S | 1 |
| Drozdowicz, D | 1 |
| Mazurkiewicz-Janik, M | 1 |
| Nawrot-Porabka, K | 1 |
| Kjellman, BF | 1 |
| Beck-Friis, J | 1 |
| Ljunggren, JG | 1 |
| Wetterberg, L | 1 |
| Tenn, C | 1 |
| Niles, LP | 1 |
| Holliman, BJ | 1 |
| Chyka, PA | 1 |
| Dembinski, A | 1 |
| Zembala, M | 1 |
| Mytar, B | 1 |
| Hahn, EG | 2 |
| Pajdo, R | 1 |
| Brzozowska, I | 1 |
| Sosnovskiĭ, AS | 1 |
| Pirogova, GV | 1 |
| Lopez-Gonzalez, MA | 1 |
| Guerrero, JM | 1 |
| Sanchez, B | 1 |
| Delgado, F | 1 |
| Zingarelli, B | 1 |
| Costantino, G | 1 |
| Caputi, AP | 2 |
| Muñoz-Hoyos, A | 2 |
| Molina-Carballo, A | 2 |
| Macías, M | 1 |
| Rodríguez-Cabezas, T | 2 |
| Martín-Medina, E | 1 |
| Narbona-López, E | 1 |
| Valenzuela-Ruiz, A | 1 |
| Acuña-Castroviejo, D | 2 |
| Zamors'kyĭ, II | 1 |
| Pishak, VP | 2 |
| Meshchyshen, IF | 1 |
| Qi, W | 1 |
| Tan, DX | 1 |
| Kim, SJ | 1 |
| Manchester, LC | 1 |
| Cabrera, J | 1 |
| Sainz, RM | 1 |
| Mayo, JC | 1 |
| Andant, C | 1 |
| Puy, H | 1 |
| Bogard, C | 1 |
| Faivre, J | 1 |
| Soulé, JC | 1 |
| Nordmann, Y | 1 |
| Deybach, JC | 1 |
| Sivan, Y | 1 |
| Laudon, M | 1 |
| Kuint, J | 1 |
| Zisapel, N | 1 |
| Nelson, FA | 1 |
| Farr, LA | 1 |
| Ebadi, M | 1 |
| Dugo, L | 1 |
| Serraino, I | 1 |
| Fulia, F | 1 |
| De Sarro, A | 1 |
| Martinez-Sempere, JJ | 1 |
| Ruiz-Cosano, C | 1 |
| Evtushenko, SK | 1 |
| Svechkin, OV | 1 |
| Samsonenko, RA | 1 |
| Pang, SF | 1 |
| Li, Y | 1 |
| Jiang, DH | 1 |
| Chang, B | 1 |
| Xie, BL | 1 |
| Maestroni, GJ | 1 |
| Conti, A | 1 |
| Pierpaoli, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: The BRAiN-M Study"[NCT02344316] | Phase 2 | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Melatonin for Adolescent Migraine Prevention Study (The MAP Study).[NCT03150797] | Phase 2 | 72 participants (Actual) | Interventional | 2017-08-02 | Terminated (stopped due to Insufficient Fund) | ||
| The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172] | Phase 2 | 60 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| The Impact of Ramelteon on Sleep and Delirium in Patients Who Undergo Pulmonary Thromboendarterectomy (PTE) Surgery[NCT02691013] | 120 participants (Actual) | Interventional | 2016-02-29 | Active, not recruiting | |||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Prevention of Delirium in Inpatients Utilizing Melatonin[NCT02654314] | Phase 3 | 277 participants (Actual) | Interventional | 2016-07-31 | Terminated (stopped due to Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.) | ||
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| Circadian Misalignment as a Disease Risk Factor in Inflammatory Bowel Disease[NCT04637399] | 52 participants (Actual) | Observational | 2016-11-22 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants that had ≥85% headache diary compliance during weeks 12-16 of the study. (NCT02344316)
Timeframe: Weeks 12-16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 11 |
| Placebo | 10 |
eCAP tack caps will be used to measure medication adherence and the number of openings will be recorded per participant. (NCT02344316)
Timeframe: "during the At Home Active Study Period or Weeks 5-16"
| Intervention | Mean Number of Openings (Mean) |
|---|---|
| Melatonin | 39 |
| Placebo | 60 |
Number of Migraine/Migrainous Days Per 28 Day Period in melatonin group and placebo group as measured using an online/mobile device headache diary. (NCT02344316)
Timeframe: final 4 weeks of treatment
| Intervention | days (Mean) |
|---|---|
| Melatonin | 3.6 |
| Placebo | 4.9 |
Number of minutes to sleep onset as measured by a FitBit. (NCT02344316)
Timeframe: 16 weeks
| Intervention | minutes (Mean) |
|---|---|
| Melatonin | 15.2 |
| Placebo | 17.2 |
Change in mean migraine/migrainous days from weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase for each group. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | -1 |
| Placebo Oral Capsule | 0 |
Mean CASQ score in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. The CASQ is a 16-question instrument that uses Likert-like responses and has a score range from 16-80; higher scores indicate greater sleepiness (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | points (Mean) |
|---|---|
| Melatonin 3mg | 33 |
| Melatonin 6mg | 36 |
| Placebo Oral Capsule | 28 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 3 mg vs. placebo. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. melatonin 3 mg. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. placebo. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin treated participants vs. placebo. (Ultimately, as the data were not normally distributed, medians were more appropriate). (NCT03150797)
Timeframe: weeks 5-8 of randomized treatment phase
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Number of days acute medication is used in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to the number of days that medication for the acute treatment of headache was used during the time frame. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 5 |
| Melatonin 6mg | 3 |
| Placebo Oral Capsule | 3 |
Number of headache days in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to number of headache days during the time period--regardless of whether they were migraine or not. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 8 |
| Melatonin 6mg | 4 |
| Placebo Oral Capsule | 5 |
Measured twice daily during the ICU stay using the Confusions Assessment Method instrument. (NCT02691013)
Timeframe: Twice daily for up to 10 days
| Intervention | hours (Median) |
|---|---|
| Placebo | 16 |
| Ramelteon | 24 |
(NCT02691013)
Timeframe: Duration of hospital admission
| Intervention | days (Median) |
|---|---|
| Placebo | 12 |
| Ramelteon | 12 |
(NCT02691013)
Timeframe: Duration of hospital admission
| Intervention | days (Median) |
|---|---|
| Placebo | 4 |
| Ramelteon | 4 |
Measured twice daily over the course of the ICU stay using the Confusion Assessment Method instrument (NCT02691013)
Timeframe: Twice daily for up to 10 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 22 |
| Ramelteon | 19 |
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
Days utilizing restraints is defined as the number of days restraints were applied because of delirium in the first 14 days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
| Intervention | days (Median) |
|---|---|
| Melatonin | 0 |
| Cellulose Microcrystylline | 0 |
Delirium is defined by the Short Form Confusion Assessment Method (CAM). There must be inattention and either an acute or fluctuating course plus either disorganized thinking or an altered level of consciousness to be diagnosed with delirium. Presented is a count of individuals with reported delirium during hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 2 |
| Cellulose Microcrystylline | 8 |
Length of stay is defined as the total time hospitalized for the acute illness (in days). (NCT02654314)
Timeframe: from day of admission to completion of acute care, not to exceed 30 days
| Intervention | days (Mean) |
|---|---|
| Melatonin | 4.58 |
| Cellulose Microcrystylline | 4.71 |
Number of delirium anti-psychotic drug doses given for symptoms of delirium. Presented are the number of doses per days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
| Intervention | number of doses per days of hospitalizat (Median) |
|---|---|
| Melatonin | 0 |
| Cellulose Microcrystylline | 0 |
7 reviews available for melatonin and Acute Disease
| Article | Year |
|---|---|
The role of melatonin in pancreatic protection: could melatonin be used in the treatment of acute pancreatitis?
Topics: Acute Disease; Humans; Melatonin; Pancreas; Pancreatitis; Receptors, Melatonin | 2014 |
Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Ghrelin; Humans; Inflammation Mediators; Leptin; M | 2014 |
[Schizophrenia and circadian rhythms].
Topics: Acute Disease; Antipsychotic Agents; Circadian Rhythm; Humans; Melatonin; Recurrence; Schizophrenia; | 2009 |
[Protective role of melatonin in pancreatic gland disorders].
Topics: Acute Disease; Animals; Central Nervous System Depressants; Diabetes Mellitus; Humans; Melatonin; Pa | 2012 |
Sleep in acute care units.
Topics: Acute Disease; Chronobiology Disorders; Cues; Electroencephalography; Environment; Health Personnel; | 2006 |
Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Cholecystokinin; Free Radical Scavengers; Gastrointest | 2007 |
Pharmacological actions of melatonin in acute and chronic inflammation.
Topics: Acute Disease; Animals; Chronic Disease; Humans; Inflammation; Melatonin; Oxidants; Oxidative Stress | 2002 |
6 trials available for melatonin and Acute Disease
| Article | Year |
|---|---|
Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial.
Topics: Acute Disease; Adolescent; Central Nervous System Depressants; Child; Child, Preschool; Female; Huma | 2020 |
Observation and analysis of clinical efficacy of melatonin on AOPP-induced delirium patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Delirium; Female; Humans; Male; Melatonin; Middle Aged; Orga | 2018 |
Changes in cognitive symptoms after a buspirone-melatonin combination treatment for Major Depressive Disorder.
Topics: Acute Disease; Antioxidants; Buspirone; Cognition Disorders; Depressive Disorder, Major; Double-Blin | 2015 |
[The complex treatment of odontogenic periostitis and the opportunity to estimate the speed of regression of inflammatory process in gerontostomatology].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Humans; Jaw | 2008 |
Excess diuresis and natriuresis during acute sleep deprivation in healthy adults.
Topics: Acute Disease; Adolescent; Adult; Aldosterone; Angiotensin II; Arginine Vasopressin; Atrial Natriure | 2010 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Central Nervous System Depressants; Delirium; Double-Blind M | 2011 |
68 other studies available for melatonin and Acute Disease
| Article | Year |
|---|---|
Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Galactosamine; | 2020 |
Assessment of the protective and therapeutic effect of melatonin against thioacetamide-induced acute liver damage.
Topics: Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2020 |
Melatonin Prevents Early but Not Delayed Ventricular Fibrillation in the Experimental Porcine Model of Acute Ischemia.
Topics: Acute Disease; Animals; Cardiac Electrophysiology; Central Nervous System Depressants; Electrophysio | 2020 |
Anti-Inflammatory Effects of Melatonin and 5-Methoxytryptophol on Lipopolysaccharide-Induced Acute Pulpitis in Rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Female; Indoles; Interleukin-1beta; Lipopolysaccha | 2021 |
Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro.
Topics: Acute Disease; Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Interl | 2021 |
Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, A | 2018 |
Melatonin Attenuates Endoplasmic Reticulum Stress in Acute Pancreatitis.
Topics: Acute Disease; Animals; Antioxidants; Apoptosis; Cell Line; Ceruletide; Cytokines; Endoplasmic Retic | 2018 |
THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.
Topics: Acute Disease; Animals; Cytoprotection; Disaccharides; Disease Models, Animal; Male; Melatonin; Panc | 2018 |
[THE INFLUENCE OF THE MELATONIN ON THE CORRELATION BETWEEN THE INTENSITY OF THE ACCUMULATION OF THE OXIDATI-VE-MODIFIED PROTEINS CONTENT, ACTIVITY OF THE ANTIOXIDANT ENZYMES AND THE STATE OF PROTEOLYSIS IN THE BASAL NUCLEI OF THE BRAIN UNDER THE ACUTE HYP
Topics: Acute Disease; Animals; Antioxidants; Basal Ganglia; Female; Hypoxia, Brain; Male; Melatonin; Oxidat | 2016 |
Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Biomarkers; Endoplasmic Reticulum Stress; Inflammation; Male; Mel | 2018 |
Effects of melatonin on acute brain reperfusion stress: role of Hippo signaling pathway and MFN2-related mitochondrial protection.
Topics: Acute Disease; Animals; Apoptosis; Brain; Cell Line, Tumor; Energy Metabolism; Gene Knockdown Techni | 2019 |
Plasma levels of melatonin in dilated cardiomyopathy.
Topics: Acute Disease; Aged; Cardiomyopathy, Dilated; Echocardiography; Female; Humans; Male; Melatonin; Mid | 2019 |
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; APACHE; Biomarkers; Case-Control Studies; | 2013 |
Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Antioxidants; Ceruletide; Cytokines; Fem | 2013 |
[Results of dynamic assessment of melatonin receptor expression in lymphocytes in patients with acute mild and severe pancreatitis].
Topics: Acute Disease; Adult; Female; Fluorescent Antibody Technique, Indirect; Humans; Lymphocytes; Male; M | 2014 |
Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Animals; Antioxidants; Ceruletide; Cytoprotection; Disease Models, Animal; Female; Gl | 2014 |
[Effect of melatonin on lipid peroxidation in the blood of rats with various behavioral characteristics during acute emotional stress].
Topics: Acute Disease; Animals; Electric Stimulation; Emotions; Free Radicals; Immobilization; Injections, I | 2014 |
Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies.
Topics: Acute Disease; Aldehydes; Amylases; Animals; Anti-Inflammatory Agents; Antioxidants; bcl-2-Associate | 2016 |
Low urinary 6-sulphatoxymelatonin concentrations in acute migraine.
Topics: Acute Disease; Adolescent; Adult; Aged; Chi-Square Distribution; Enzyme-Linked Immunosorbent Assay; | 2008 |
Low urinary 6-sulphatoxymelatonin concentrations in acute migraine.
Topics: Acute Disease; Adolescent; Adult; Aged; Chi-Square Distribution; Enzyme-Linked Immunosorbent Assay; | 2008 |
Low urinary 6-sulphatoxymelatonin concentrations in acute migraine.
Topics: Acute Disease; Adolescent; Adult; Aged; Chi-Square Distribution; Enzyme-Linked Immunosorbent Assay; | 2008 |
Low urinary 6-sulphatoxymelatonin concentrations in acute migraine.
Topics: Acute Disease; Adolescent; Adult; Aged; Chi-Square Distribution; Enzyme-Linked Immunosorbent Assay; | 2008 |
Melatonin and its precursor L-tryptophan prevent acute gastric mucosal damage induced by aspirin in humans.
Topics: Acute Disease; Adult; Aspirin; Dose-Response Relationship, Drug; Free Radical Scavengers; Gastric Mu | 2008 |
The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis.
Topics: Acute Disease; Adult; Circadian Rhythm; Comorbidity; Depressive Disorder, Major; Disability Evaluati | 2008 |
The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Injections, Intraperitoneal; | 2009 |
Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Enzyme Induction; Gastri | 2009 |
Melatonin modulates acute testicular damage induced by carbon ions in mice.
Topics: Acute Disease; Animals; Antioxidants; Apoptosis; Carbon; Comet Assay; DNA Damage; Glutathione; Male; | 2009 |
Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Glutathione; Injections, I | 2010 |
Protective role of endogenous melatonin in the early course of human acute pancreatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antioxidants; E | 2011 |
Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation.
Topics: Acute Disease; Animals; Apoptosis; Atrophy; Disease Models, Animal; Injections, Intraperitoneal; Lig | 2010 |
Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: protection by melatonin and cranberry flavonoids.
Topics: Acute Disease; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; | 2012 |
Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22.
Topics: Acute Disease; Acute Lung Injury; Amylases; Animals; Immunity, Innate; Interleukin-22; Interleukins; | 2012 |
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Cytokines; Escherichia coli; Interleukin-6; Kidney | 2013 |
Protective effect of melatonin in carrageenan-induced acute local inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relation | 2002 |
Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain Edema; Coloring Agents; Ischemic Attac | 2002 |
Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury.
Topics: Acute Disease; Alprostadil; Animals; Antioxidants; Aryldialkylphosphatase; Biomarkers; Disease Model | 2003 |
Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action.
Topics: Acute Disease; Aldehydes; Amylases; Animals; Ceruletide; Dose-Response Relationship, Drug; Drug Admi | 2004 |
Role of melatonin in reducing water avoidance stress-induced degeneration of the liver.
Topics: Acute Disease; Animals; Avoidance Learning; Chronic Disease; Free Radical Scavengers; Glutathione; L | 2005 |
[Circadian rhythm in acute coronary syndrome].
Topics: Acute Disease; Circadian Rhythm; Coronary Artery Disease; Humans; Melatonin; Periodicity; Pineal Gla | 2005 |
Melatonin restores the cytochrome oxidase reactivity in the nodose ganglia of acute hypoxic rats.
Topics: Acute Disease; Animals; Antioxidants; Dose-Response Relationship, Drug; Electron Transport Complex I | 2005 |
Delayed neutrophil apoptosis attenuated by melatonin in human acute pancreatitis.
Topics: Acute Disease; Adult; Apoptosis; CD18 Antigens; DNA Damage; Dose-Response Relationship, Drug; Female | 2005 |
Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Autophagy; Catalase; Ceruletide; Female; Glutathione; Glutathione | 2006 |
Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Arginine; Catalase; Lipid Peroxidation; Male; Malondialdehyde; Mel | 2006 |
Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats.
Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Ascorbic Acid; Ceruletide; Female; Lipid Perox | 2006 |
Protective effect of melatonin against maternal deprivation-induced acute hippocampal damage in infant rats.
Topics: Acute Disease; Animals; Benzoxazines; Coloring Agents; Female; Hippocampus; In Situ Nick-End Labelin | 2006 |
Effects of combination of melatonin and dexamethasone on acute lung injury in a mice model of carrageenan-induced pleurisy.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Dexamethasone; Disease Models, Animal | 2006 |
Effect of melatonin on the thymus, adrenal glands, and spleen in rats during acute stress.
Topics: Acute Disease; Adrenal Glands; Animals; Male; Melatonin; Organ Size; Rats; Rats, Wistar; Spleen; Str | 2006 |
[Protective effect of melatonin and sodium thiosulphate on histopathology and ultrastructure of the kidney in rats with acute paraquat poisoning].
Topics: Acute Disease; Animals; Antidotes; Antioxidants; Drug Evaluation, Preclinical; Kidney Tubular Necros | 2007 |
Protective influence of melatonin against acute esophageal lesions involves prostaglandins, nitric oxide and sensory nerves.
Topics: Acute Disease; Animals; Dinoprostone; Esophagus; Gastroesophageal Reflux; Male; Melatonin; Neurons, | 2007 |
Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis.
Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Arginine; Ascorbic Acid; Ceruletide; Female; L | 2008 |
Role of circadian rhythm and endogenous melatonin in pathogenesis of acute gastric bleeding erosions induced by stress.
Topics: Acute Disease; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Me | 2007 |
Twenty-four-hour serum levels of TSH in affective disorders.
Topics: Acute Disease; Adult; Bipolar Disorder; Depressive Disorder; Dexamethasone; Female; Humans; Lithium; | 1984 |
Physiological regulation of melatonin receptors in rat suprachiasmatic nuclei: diurnal rhythmicity and effects of stress.
Topics: Acute Disease; Animals; Circadian Rhythm; Guanosine Triphosphate; Male; Melatonin; Protein Binding; | 1993 |
Problems in assessment of acute melatonin overdose.
Topics: Acute Disease; Aged; Diagnosis, Differential; Drug Overdose; Humans; Male; Melatonin | 1997 |
Gastroprotective activity of melatonin and its precursor, L-tryptophan, against stress-induced and ischaemia-induced lesions is mediated by scavenge of oxygen radicals.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; DNA; Dose-Resp | 1997 |
The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; DNA; Dose-Response Relatio | 1997 |
[Melatonin and gastric ulcer development during acute emotional stress in rats].
Topics: Acute Disease; Animals; Injections, Intraperitoneal; Male; Melatonin; Rats; Rats, Wistar; Stomach Ul | 1998 |
Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis.
Topics: Acute Disease; Adolescent; B-Lymphocyte Subsets; Cells, Cultured; Child; Child, Preschool; Female; H | 1998 |
Protective effect of melatonin in a non-septic shock model induced by zymosan in the rat.
Topics: Acute Disease; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemotaxis, Leukocyte; | 1998 |
Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress.
Topics: Acute Disease; Circadian Rhythm; Female; Fetal Blood; Fetal Distress; Humans; Indoles; Infant, Newbo | 1998 |
[The effect of melatonin on photoperiod changes in the glutathione system of the brain under acute hypoxia].
Topics: Acute Disease; Altitude; Animals; Antioxidants; Atmosphere Exposure Chambers; Brain; Brain Chemistry | 1999 |
Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Edema; Free Radical Scavengers; Lipid Peroxidation; Ma | 1999 |
Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors.
Topics: Acute Disease; Adult; Carcinoma, Hepatocellular; Cohort Studies; Female; Heme; Humans; Incidence; Li | 2000 |
Low melatonin production in infants with a life-threatening event.
Topics: Acute Disease; Case-Control Studies; Female; Humans; Infant; Infant, Newborn; Male; Melatonin; Nucle | 2000 |
Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia.
Topics: Acute Disease; Animals; Cyclic AMP; Cyclic GMP; Enzyme Activation; Habenula; Heme Oxygenase (Decycli | 2000 |
Salivary melatonin response to acute pain stimuli.
Topics: Acute Disease; Adult; Analgesia; Circadian Rhythm; Electroshock; Female; Humans; Male; Melatonin; Mi | 2001 |
Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation.
Topics: Acute Disease; Animals; Carrageenan; Disease Models, Animal; DNA Damage; Energy Metabolism; Enzyme A | 2001 |
Melatonin concentration in the umbilical artery and vein in human preterm and term neonates and neonates with acute fetal distress.
Topics: Acute Disease; Circadian Rhythm; Fetal Blood; Fetal Distress; Gestational Age; Humans; Infant, Newbo | 1992 |
[Relations of melatonin level and insufficiency of T and B immune components in children with acute viral neuroinfections].
Topics: Acute Disease; Adjuvants, Immunologic; Adolescent; Child; Humans; Hydrocortisone; Immunity, Cellular | 1990 |
Acute cerebral hemorrhage changes the nocturnal surge of plasma melatonin in humans.
Topics: Acute Disease; Adolescent; Adult; Aged; Cerebral Hemorrhage; Circadian Rhythm; Female; Humans; Male; | 1990 |
Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism.
Topics: Acute Disease; Animals; Antibody Formation; Endorphins; Female; Immune Tolerance; Melatonin; Mice; M | 1988 |