Page last updated: 2024-10-19

melatonin and 2019 Novel Coronavirus Disease

melatonin has been researched along with 2019 Novel Coronavirus Disease in 101 studies

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of melatonin versus placebo on the incidence of acute kidney injury (AKI) in patients treated with polymyxin B."9.69Melatonin for prevention of acute kidney injury in patients treated with intravenous polymyxin B: a double-blind, placebo-controlled randomized clinical trial. ( Baldissera, G; Barros, A; Beck, E; Bergo, P; Budelon Gonçalves, JI; Caumo, W; David, L; Falci, D; Rigatto, MH; Santoro, L; Zanin, R; Zavascki, AP, 2023)
"This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19)."9.51The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients. ( Atrakji, DMQYMAA; Hasan, ZT; Mehuaiden, DAK, 2022)
"We set out to perform a narrative review to synthesize the current evidence in this area in respect of our hypothesis that melatonin may be linked with anosmia and play a part in oxidative stress and the regulation of inflammation."9.22Could melatonin have a potential adjuvant role in the treatment of the lasting anosmia associated with COVID-19? A review. ( Andersen, ML; Arakaki, FH; Facina, ADS; Morelhao, PK; Tomimori, J; Tufik, S; Xavier, SD; Xerfan, EMS, 2022)
"The aim of this review is to summarize current studies on the relationship between melatonin and aging."9.05Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly? ( Akbulut, KG; Güney, Ş; Öztürk, G, 2020)
"In this study, we aimed to measure the melatonin levels in COVID-19 positive patients and to investigate the relationship of these levels with depression, death anxiety and insomnia."8.31Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia. ( Öner, P; Yılmaz, S, 2023)
" Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation."8.02A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement. ( Alizadeh, Z; Dashti-Khavidaki, S; Ghaderkhani, S; Keyhanian, N; Pourpak, Z; Shokouhi Shoormasti, R, 2021)
"Melatonin is an indole hormone secreted primarily by the pineal gland that showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity."6.82Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action. ( Agüera, E; Caballero-Villarraso, J; Escribano, BM; Galván, A; Muñoz-Jurado, A; Santamaría, A; Túnez, I, 2022)
"Melatonin is a multifunctional signaling hormone synthesized and secreted primarily by the pineal gland."6.66Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19. ( El-Missiry, MA; El-Missiry, ZMA; Othman, AI, 2020)
"To evaluate the effect of melatonin versus placebo on the incidence of acute kidney injury (AKI) in patients treated with polymyxin B."5.69Melatonin for prevention of acute kidney injury in patients treated with intravenous polymyxin B: a double-blind, placebo-controlled randomized clinical trial. ( Baldissera, G; Barros, A; Beck, E; Bergo, P; Budelon Gonçalves, JI; Caumo, W; David, L; Falci, D; Rigatto, MH; Santoro, L; Zanin, R; Zavascki, AP, 2023)
"This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19)."5.51The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients. ( Atrakji, DMQYMAA; Hasan, ZT; Mehuaiden, DAK, 2022)
"We set out to perform a narrative review to synthesize the current evidence in this area in respect of our hypothesis that melatonin may be linked with anosmia and play a part in oxidative stress and the regulation of inflammation."5.22Could melatonin have a potential adjuvant role in the treatment of the lasting anosmia associated with COVID-19? A review. ( Andersen, ML; Arakaki, FH; Facina, ADS; Morelhao, PK; Tomimori, J; Tufik, S; Xavier, SD; Xerfan, EMS, 2022)
"The aim of this review is to summarize current studies on the relationship between melatonin and aging."5.05Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly? ( Akbulut, KG; Güney, Ş; Öztürk, G, 2020)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"In this study, we aimed to measure the melatonin levels in COVID-19 positive patients and to investigate the relationship of these levels with depression, death anxiety and insomnia."4.31Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia. ( Öner, P; Yılmaz, S, 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
" Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation."4.02A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement. ( Alizadeh, Z; Dashti-Khavidaki, S; Ghaderkhani, S; Keyhanian, N; Pourpak, Z; Shokouhi Shoormasti, R, 2021)
" This is due to hyperglycemia, the higher prevalence of sleep disorders and also the low levels of melatonin, a substance with anti-inflammatory actions, in these patients."4.02Possible role of exogenous melatonin in preventing more serious COVID-19 infection in patients with type 2 diabetes mellitus. ( Martorina, WJ; Tavares, A, 2021)
" Melatonin significantly improved clinical status with a safe profile in patients with severe COVID-19 pneumonia."3.30Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial. ( Ameri, A; Fathalipour, M; Frouz Asadi, M; Hassanipour, S; Kamali, M; Mahmoodi, M; Safa, O; Vatankhah, M; Ziaei, A, 2023)
"Melatonin has been known as an anti-inflammatory agent and immune modulator that may address progressive pathophysiology of coronavirus disease 2019 (COVID-19)."3.11Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial. ( Aghamollaei, H; Akbariqomi, M; Alishiri, G; Badri, T; Bagheri, M; Farnoosh, G; Fasihi-Ramandi, M; Ghaleh, HEG; Hassanpour, K; Izadi, M; Rezaie, E; Saeedi-Boroujeni, A, 2022)
"Melatonin was found to have substantial effects on COVID-19 patients when used as adjuvant therapy, enhancing clinical improvement and decreasing time to recovery with a shorter length of hospital stay and a shorter duration of mechanical ventilation."3.01Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis. ( Abd El-Tawab Moawad, W; Adel Abdelkader Saed, S; Al-Hejazi, T; Hossam-Eldin Moawad, M; Mohamed Taha, A; Mousa, Y; Reiter, RJ; Sharma, R, 2023)
"Melatonin have been identified as having the potential to manage patients with COVID-19 along with standard care."3.01Role of Supplements in the Management of COVID-19 - A Comprehensive Review. ( Balasubramanian, R; Jahir Hussain, MH; Maideen, NMP; Muthusamy, S; Ramanathan, S, 2023)
"Our goal in the management of acute and long COVID is to synchronize the medication regimen with the patient's biological rhythm."3.01Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach. ( Abacioglu, N; Chuckwunyere, U; Erdag, E; Haskologlu, IC; Mercan, M; Sehirli, AO; Taner, N; Ulker, D, 2023)
" The secondary outcomes are the time to improve clinical and paraclinical features along with the incidence of serious adverse drug reactions within seven days of randomization."2.94Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial. ( Dadvand, H; Davoodian, P; Fathalipour, M; Hassanipour, S; Mahmoudikia, F; Masjedi, M; Omidi, M; Rafiee, B; Safa, O; Ziaei, A, 2020)
" ◦ To evaluate adverse events during the 28 day study period."2.94A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protoc ( Acuña-Castroviejo, D; Borobia, AM; de la Oliva, P; Escames, G; Figueira, JC; Rodríguez-Rubio, M, 2020)
"Melatonin has significant anti-inflammatory, antioxidant, and mitochondrial protective effects, and its efficacy has been demonstrated in multiple experimental models of disease and in a clinical trial in sepsis."2.94Clinical trial to test the efficacy of melatonin in COVID-19. ( Acuña-Castroviejo, D; Acuña-Fernández, C; Borobia, AM; de la Oliva, P; Escames, G; Figueira, JC, 2020)
"Melatonin is a molecule with multiple activities on a virus infection."2.82Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality. ( Reiter, RJ; Tan, DX, 2022)
"Melatonin is an indole hormone secreted primarily by the pineal gland that showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity."2.82Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action. ( Agüera, E; Caballero-Villarraso, J; Escribano, BM; Galván, A; Muñoz-Jurado, A; Santamaría, A; Túnez, I, 2022)
"Melatonin has pan-antiviral effects and it diminishes the severity of viral infections and reduces the death of animals infected with numerous different viruses, including three different coronaviruses."2.82Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection. ( Cardinali, DP; Dominguez-Rodriguez, A; Kleszczynski, K; Manucha, W; Martin-Gimenez, VM; Neel, RL; Reiter, RJ; Sharma, R; Simko, F; Slominski, AT; Tesarik, J, 2022)
"Phytomelatonin is a pleiotropic molecule that originated in higher plants with many diverse actions and is primarily an antioxidant."2.82Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals. ( Nkwoemeka, NE; Nweze, EJ; Ogugofor, MO; Okeke, ES; Okoye, CO, 2022)
"The symptoms of Coronavirus Disease 2019 (COVID-19) include fever, dry cough, body aches, and anosmia."2.82Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features. ( Mirsaeidi, M; Nasiri, MJ; Rommasi, F, 2022)
" The outcomes examined were the number of adverse events (AEs), serious adverse events (SAEs) and withdrawals due to AEs."2.82Safety of higher doses of melatonin in adults: A systematic review and meta-analysis. ( Chapman, JL; Comas, M; D'Rozario, AL; Duffy, SL; Gordon, CJ; Grunstein, RR; Hoyos, CM; Marshall, NS; McKinnon, AC; Menczel Schrire, Z; Naismith, SL; Phillips, CL; Raisin, I; Saini, B; Wong, G, 2022)
" An amount of 1 to 2 g per day of vitamin C demonstrated efficacy both in CRP and endothelial function, and a dosage of melatonin ranging from 5 to 25 mg /day showed good evidence of efficacy in CRP, TNF and IL6."2.72Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc. ( Argano, C; Cavezzi, A; Corrao, S; Lo Monaco, M; Mallaci Bocchio, R; Natoli, G; Troiani, E, 2021)
"Melatonin has been proposed as a safe therapeutic agent for COVID-19 recently, having been given with a US Food and Drug Administration emergency authorized cocktail, REGEN-COV2, for management of COVID-19 progression."2.72Melatonin interferes with COVID-19 at several distinct ROS-related steps. ( Abu-Soud, HM; Bai, D; Camp, OG; Gonullu, DC; Nayak, N, 2021)
"Melatonin may also increase the efficacy of COVID-19 vaccination."2.72Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders. ( Cubała, WJ; Kania, A; Siemiński, M; Wichniak, A, 2021)
"Melatonin is a multifunctional signaling hormone synthesized and secreted primarily by the pineal gland."2.66Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19. ( El-Missiry, MA; El-Missiry, ZMA; Othman, AI, 2020)
"Viral infections are dangerous diseases for human health worldwide, which lead to significant morbidity and mortality each year."2.66Melatonin potentials against viral infections including COVID-19: Current evidence and new findings. ( Bahrampour Juybari, K; Hemati, K; Hosseinzadeh, A; Mehrzadi, S; Pourhanifeh, MH, 2020)
"Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits."2.66Melatonin's Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease. ( Chitimus, DM; Panaitescu, AM; Pavel, B; Popescu, MR; Voiculescu, SE; Zagrean, AM; Zagrean, L, 2020)
"Melatonin is a molecule that can enhance the host's tolerance against pathogen invasions."2.66Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19. ( Hardeland, R; Tan, DX, 2020)
"The origin of the coronavirus disease 2019 (COVID-19) pandemic is zoonotic."2.66Artificial Light at Night (ALAN): A Potential Anthropogenic Component for the COVID-19 and HCoVs Outbreak. ( Chattoraj, A; Devi, SD; Khan, ZA; Labala, RK; Mondal, G; Rajiv, C; Sanjita Devi, H; Yumnamcha, T, 2020)
"Melatonin is a physiological indoleamine involved in circadian rhythm regulation and it is currently used for secondary sleep disorders caused by various diseases."1.91Melatonin effects on sleep quality of COVID-19 patients: a protocol for systematic review and meta-analysis of randomised controlled trials with trial sequential analysis. ( Guo, S; Sun, R; Zhang, H; Zhang, JJ, 2023)
"Melatonin is a safe medication with multiple uses in sleep medicine for the treatment of circadian rhythm disorders, insomnia, and REM sleep behavior disorder."1.72[Pre-pandemic melatonin treatment for sleep disorders and COVID-19 infection. A retrospective cross-sectional study]. ( Cardinali, DP; Folgueira, A; González Cardozo, A; Rugiero, M; Valiensi, SM; Vera, VA, 2022)
"The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights major gaps in our knowledge on the prevention control and cross-species transmission mechanisms of animal coronaviruses."1.62Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations. ( Jiao, H; Li, C; Reiter, RJ; Ren, W; Su, S; Wang, N; Zhai, X; Zhang, J, 2021)
"Pediatric COVID-19 delirium is a new manifestation of the COVID-19 disease."1.62Pediatric COVID-19 Delirium: Case Report of 2 Adolescents. ( Bauer, SC; Logan, A; Manak, C; Mitchell, M; Moral, F; Preloger, E; Roman, M; Sandage, SJ; Spindler, A, 2021)
"Melatonin is a natural hormone that has been shown highly antioxidant effects."1.62Molecular insight on the formation structure and dynamics of melatonin in an aqueous solution and at the Water-Air interface: A molecular dynamics study. ( Khajonrit, J; Krongsuk, S; Maensiri, S; Ritwiset, A, 2021)

Research

Studies (101)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's101 (100.00)2.80

Authors

AuthorsStudies
Mousavi, SA1
Heydari, K1
Mehravaran, H1
Saeedi, M1
Alizadeh-Navaei, R1
Hedayatizadeh-Omran, A1
Shamshirian, A1
Okeke, ES1
Ogugofor, MO1
Nkwoemeka, NE1
Nweze, EJ1
Okoye, CO1
Cecon, E1
Izabelle, C1
Poder, SL1
Real, F1
Zhu, A1
Tu, L1
Ghigna, MR1
Klonjkowski, B1
Bomsel, M1
Jockers, R1
Dam, J1
Hasan, ZT1
Atrakji, DMQYMAA1
Mehuaiden, DAK1
Mou, Q1
Yang, YW1
Chen, L2
Fang, T1
Yao, YC1
Du, ZQ1
Yang, CX1
Kow, CS2
Ramachandram, DS1
Hasan, SS2
Menczel Schrire, Z1
Phillips, CL1
Chapman, JL1
Duffy, SL1
Wong, G1
D'Rozario, AL1
Comas, M1
Raisin, I1
Saini, B1
Gordon, CJ1
McKinnon, AC1
Naismith, SL1
Marshall, NS1
Grunstein, RR1
Hoyos, CM1
Rommasi, F1
Nasiri, MJ1
Mirsaeidi, M1
Song, Z1
Bao, L1
Deng, W1
Liu, J3
Ren, E1
Lv, Q1
Liu, M3
Qi, F1
Chen, T1
Deng, R1
Li, F1
Liu, Y3
Wei, Q1
Gao, H1
Yu, P1
Han, Y1
Zhao, W1
Zheng, J1
Liang, X1
Yang, F1
Qin, C1
Tan, DX2
Reiter, RJ17
Afshar, EA1
Taher, MA1
Karimi, F1
Karaman, C1
Moradi, O1
Sánchez-Rico, M1
de la Muela, P1
Herrera-Morueco, JJ1
Geoffroy, PA1
Limosin, F1
Hoertel, N1
Sharma, R2
Simko, F3
Dominguez-Rodriguez, A2
Tesarik, J2
Neel, RL1
Slominski, AT2
Kleszczynski, K2
Martin-Gimenez, VM1
Manucha, W3
Cardinali, DP3
Hosseinzadeh, MH1
Goodarzi, A1
Malekan, M1
Ebrahimzadeh, MA1
Valiensi, SM1
Folgueira, A1
Vera, VA1
González Cardozo, A1
Rugiero, M1
Stone, JE2
Wiley, J1
Chachos, E2
Hand, AJ2
Lu, S2
Raniti, M1
Klerman, E1
Lockley, SW2
Carskadon, MA2
Phillips, AJK2
Bei, B2
Rajaratnam, SMW2
Chattree, V1
Singh, K2
Goel, A1
Maity, A1
Lone, A1
Muñoz-Jurado, A1
Escribano, BM1
Caballero-Villarraso, J1
Galván, A1
Agüera, E1
Santamaría, A1
Túnez, I1
Xerfan, EMS1
Morelhao, PK1
Arakaki, FH1
Facina, ADS1
Tomimori, J1
Xavier, SD1
Tufik, S1
Andersen, ML1
Lins-Filho, O1
Pedrosa, RP1
Loh, D1
Hosseinzadeh, A3
Bagherifard, A1
Koosha, F1
Amiri, S1
Karimi-Behnagh, A1
Mehrzadi, S3
Fernandes, PACM1
Markus, RP1
Kinker, GS1
Minich, DM1
Henning, M1
Darley, C1
Fahoum, M1
Schuler, CB1
Frame, J1
Ameri, A4
Frouz Asadi, M3
Ziaei, A5
Vatankhah, M4
Safa, O5
Kamali, M4
Fathalipour, M5
Mahmoodi, M3
Hassanipour, S4
Rigatto, MH1
Bergo, P1
Baldissera, G1
Beck, E1
David, L1
Santoro, L1
Barros, A1
Zanin, R1
Budelon Gonçalves, JI1
Falci, D1
Caumo, W1
Zavascki, AP1
Yiang, GT1
Wu, CC1
Lu, CL1
Hu, WC1
Tsai, YJ1
Huang, YM1
Su, WL1
Lu, KC1
Yılmaz, S1
Öner, P1
Balasubramanian, R1
Maideen, NMP1
Muthusamy, S1
Ramanathan, S1
Jahir Hussain, MH1
Hasebe, K1
Watanabe, D1
Yamaguchi, T1
Hu, A1
Tabuchi, M1
Kuwashima, Y1
Watanabe, A1
Hikima, N1
Uehara, Y1
Mizushima, S1
Okuno, S1
Mizushima, A1
Alobaidy, ASH1
Elhelaly, M1
Amer, ME1
Shemies, RS1
Othman, AI2
El-Missiry, MA2
França, DCH1
Fujimori, M1
de Queiroz, AA1
Borges, MD1
Magalhães Neto, AM1
de Camargos, PJV1
Ribeiro, EB1
França, EL1
Honorio-França, AC1
Fagundes-Triches, DLG1
Khezri, MR1
Varzandeh, R1
Ghasemnejad-Berenji, M1
Esquivel-Mendoza, J1
Burgess, HJ1
Gren, LH1
Shoaf, K1
Baron, KG1
Carson, M1
Moore, M1
Cicalese, O1
Dunnewald, M1
Varker, A1
Mindell, JA1
Williamson, AA1
Zhang, JJ1
Sun, R1
Guo, S1
Zhang, H1
Taner, N1
Haskologlu, IC1
Erdag, E1
Mercan, M1
Chuckwunyere, U1
Ulker, D1
Sehirli, AO4
Abacioglu, N1
Mohamed Taha, A1
Adel Abdelkader Saed, S1
Hossam-Eldin Moawad, M1
Abd El-Tawab Moawad, W1
Al-Hejazi, T1
Mousa, Y1
Zhang, R3
Wang, X2
Ni, L1
Di, X1
Ma, B1
Niu, S1
Liu, C4
Anderson, G1
Salles, C1
Shneider, A1
Kudriavtsev, A1
Vakhrusheva, A1
Herrera, EA1
González-Candia, A1
Zambrelli, E2
Canevini, M1
Gambini, O1
D'Agostino, A2
Martín Giménez, VM2
Inserra, F1
Tajer, CD1
Mariani, J1
Ferder, L1
Banerjee, A1
Czinn, SJ1
Blanchard, TG1
García, IG1
Rodriguez-Rubio, M2
Mariblanca, AR1
de Soto, LM1
García, LD1
Villatoro, JM1
Parada, JQ1
Meseguer, ES1
Rosales, MJ1
González, J1
Arribas, JR1
Carcas, AJ1
de la Oliva, P3
Borobia, AM3
Wiwanitkit, V1
Bagci, S1
Sabir, H1
Müller, A1
Kloc, M1
Ghobrial, RM1
Kubiak, JZ1
El-Missiry, ZMA1
Hazra, S1
Chaudhuri, AG1
Tiwary, BK1
Chakrabarti, N1
Figueira, JC2
Acuña-Castroviejo, D2
Escames, G3
Lim, RK1
Wambier, CG1
Goren, A1
Bahrampour Juybari, K1
Pourhanifeh, MH1
Hemati, K1
Acuña-Fernández, C1
Romero, A1
Ramos, E1
López-Muñoz, F1
Gil-Martín, E1
Öztürk, G1
Akbulut, KG1
Güney, Ş1
Chitimus, DM1
Popescu, MR1
Voiculescu, SE1
Panaitescu, AM1
Pavel, B1
Zagrean, L1
Zagrean, AM1
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Li, J1
Zhang, J2
Shen, S1
Zhang, B2
Yu, WW1
Toyoda, H1
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Zhu, L1
Wang, J6
Xue, L1
Liu, L2
Yan, X2
Huang, S1
Li, Y6
Xu, T1
Li, C3
Ji, F1
Ming, F1
Zhao, Y2
Cheng, J1
Wang, Y3
Zhao, H1
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X2
Chen, Y4
Wei, J1
Zhu, C1
Wu, C1
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Lin, Y1
Dong, Y1
Wu, Y1
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
Alfawares, R1
Alobaid, A1
Rasheed, A1
Soliman, I1
Wendel Garcia, PD1
Fumeaux, T1
Guerci, P1
Heuberger, DM1
Montomoli, J2
Roche-Campo, F1
Schuepbach, RA1
Hilty, MP1
Poloni, TE1
Carlos, AF1
Cairati, M1
Cutaia, C1
Medici, V1
Marelli, E1
Ferrari, D1
Galli, A1
Bognetti, P1
Davin, A1
Cirrincione, A1
Ceretti, A1
Cereda, C1
Ceroni, M1
Tronconi, L1
Vitali, S1
Guaita, A1
Leeds, JS1
Raviprakash, V1
Jacques, T1
Scanlon, N1
Cundall, J1
Leeds, CM1
Riva, A1
Gray, EH1
Azarian, S1
Zamalloa, A1
McPhail, MJW1
Vincent, RP1
Williams, R1
Chokshi, S1
Patel, VC1
Edwards, LA1
Alqarawi, W1
Birnie, DH1
Golian, M1
Nair, GM1
Nery, PB1
Klein, A1
Davis, DR1
Sadek, MM1
Neilipovitz, D1
Johnson, CB1
Green, MS1
Redpath, C1
Miller, DC1
Beamer, P1
Billheimer, D1
Subbian, V1
Sorooshian, A1
Campbell, BS1
Mosier, JM1
Novaretti, JV1
Astur, DC1
Cavalcante, ELB1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Huang, W1
Li, T1
Ling, Y1
Qian, ZP1
Zhang, YY1
Huang, D1
Xu, SB1
Liu, XH1
Xia, L1
Yang, Y3
Lu, SH1
Lu, HZ1
Ma, JX1
Tang, S1
Li, CM1
Wan, J1
Wang, JF1
Ma, JQ1
Luo, JJ1
Chen, HY2
Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Hu, Y1
Shen, P1
Zeng, N1
Wang, L3
Yan, D1
Cui, L1
Yang, K2
Zhai, C1
Yang, M1
Lao, X1
Sun, J1
Ma, N1
Wang, S1
Ye, W1
Guo, P1
Rahimi, S1
Singh, MP1
Gupta, J1
Nakanishi, I1
Ohkubo, K1
Shoji, Y1
Fujitaka, Y1
Shimoda, K1
Matsumoto, KI1
Fukuhara, K1
Hamada, H1
van der Boom, T1
Gruppen, EG1
Lefrandt, JD1
Connelly, MA1
Links, TP1
Dullaart, RPF1
Berry, JD1
Bedlack, R1
Mathews, D1
Agnese, W1
Apple, S1
Meloncelli, S1
Divizia, M1
Germani, G1
Adefegha, SA1
Bottari, NB1
Leal, DB1
de Andrade, CM1
Schetinger, MR1
Martínez-Velasco, A1
Perez-Ortiz, AC1
Antonio-Aguirre, B1
Martínez-Villaseñor, L1
Lira-Romero, E1
Palacio-Pastrana, C1
Zenteno, JC1
Ramirez, I1
Zepeda-Palacio, C1
Mendoza-Velásquez, C1
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Estrada-Mena, FJ1
Martin, BL1
Thompson, LC1
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Schladweiler, MC1
Phillips, P1
Harmon, M1
King, C1
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Gilmour, MI1
Kodavanti, UP1
Hazari, MS1
Farraj, AK1
Shen, Z1
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Gao, K1
Lazar, S1
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Ma, P1
Goldfinger, LE1
Vukelic, M1
Laloo, A1
Kyttaris, VC1
Chen, R1
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Xun, J1
Hu, Z1
Huang, Q2
Steinhart, C1
Shen, Y1
Lu, H1
Mansuri, A1
Lokhande, K1
Kore, S1
Gaikwad, S1
Nawani, N1
Swamy, KV1
Junnarkar, M1
Pawar, S1
Shaheen, MY1
Basudan, AM1
Niazy, AA1
van den Beucken, JJJP1
Jansen, JA1
Alghamdi, HS1
Gao, Q2
Guo, X1
Cao, Y1
Jia, X1
Xu, S1
Lu, C2
Zhu, H2
Melku, M1
Abebe, G1
Teketel, A1
Asrie, F1
Yalew, A1
Biadgo, B1
Kassa, E1
Damtie, D1
Anlay, DZ1
Ahmed, MFE1
Ramadan, H1
Seinige, D1
Kehrenberg, C1
Abd El-Wahab, A1
Volkmann, N1
Kemper, N1
Schulz, J1
Hu, MY1
Wu, YN1
McEvoy, MP1
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Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts.[NCT04353128]Phase 2/Phase 3450 participants (Actual)Interventional2020-04-20Completed
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754]Phase 20 participants (Actual)Interventional2021-04-01Withdrawn (stopped due to lack of subject enrollment)
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483]Phase 28 participants (Actual)Interventional2020-11-06Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects)
Prognostic Value of Serum Melatonin as a Biomarker for the Determination of Severe COVID-19 Infection in Pregnant Women[NCT05318144]228 participants (Actual)Observational [Patient Registry]2021-06-01Completed
Randomized Controlled Trial of High Dose of Vitamin D as Compared With Placebo to Prevent Complications Among COVID-19 Patients[NCT04411446]Phase 4218 participants (Actual)Interventional2020-08-11Completed
A Phase II, Single-center, Double-blind, Randomized Placebo-controlled Trial to Explore the Efficacy and Safety of Intravenous Melatonin in Patients With COVID-19 Admitted to the Intensive Care Unit (MelCOVID Study)[NCT04568863]Phase 218 participants (Actual)Interventional2020-06-20Completed
Obstructive Sleep Apnea in Patients With Long COVID-19 Fatigue: a Multicentre Prospective Cohort Study[NCT05290350]300 participants (Anticipated)Observational2022-03-10Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

40 reviews available for melatonin and 2019 Novel Coronavirus Disease

ArticleYear
Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals.
    Microbes and infection, 2022, Volume: 24, Issue:1

    Topics: Antioxidants; COVID-19; Humans; Melatonin; Plant Growth Regulators; SARS-CoV-2

2022
Safety of higher doses of melatonin in adults: A systematic review and meta-analysis.
    Journal of pineal research, 2022, Volume: 72, Issue:2

    Topics: Adult; COVID-19; Humans; Melatonin; SARS-CoV-2; Sleep

2022
Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features.
    Molecular and cellular biochemistry, 2022, Volume: 477, Issue:3

    Topics: Antibodies, Monoclonal, Humanized; Antiviral Agents; Azetidines; COVID-19; COVID-19 Drug Treatment;

2022
Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality.
    Life sciences, 2022, Apr-01, Volume: 294

    Topics: Anti-Inflammatory Agents; Antioxidants; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome

2022
Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection.
    Cellular and molecular life sciences : CMLS, 2022, Feb-20, Volume: 79, Issue:3

    Topics: Antioxidants; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Melatonin; SARS-CoV-2

2022
A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID-19 patients by phytotherapeutic melatonin and epigallocatechin-3-gallate.
    Journal of food biochemistry, 2022, Volume: 46, Issue:12

    Topics: Antioxidants; Antiviral Agents; COVID-19; Humans; Immune System; Inflammation; Melatonin; SARS-CoV-2

2022
Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action.
    Inflammopharmacology, 2022, Volume: 30, Issue:5

    Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Catalase; COVID-19; Estrogens; Femal

2022
Could melatonin have a potential adjuvant role in the treatment of the lasting anosmia associated with COVID-19? A review.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2022, Volume: 82, Issue:6

    Topics: Anosmia; COVID-19; Humans; Melatonin; Oxidative Stress

2022
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19.
    International journal of molecular sciences, 2022, Jul-23, Volume: 23, Issue:15

    Topics: COVID-19; Host-Pathogen Interactions; Humans; Melatonin; RNA, Viral; SARS-CoV-2; Virus Replication

2022
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19.
    Life sciences, 2022, Oct-15, Volume: 307

    Topics: Angiotensin-Converting Enzyme 2; Blood Platelets; COVID-19; Cytokines; Humans; Melatonin; Peptidyl-D

2022
Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements.
    Nutrients, 2022, Sep-22, Volume: 14, Issue:19

    Topics: Animals; Antioxidants; Circadian Rhythm; COVID-19; Dietary Supplements; Humans; Melatonin; Pandemics

2022
Endoplasmic Reticulum Stress in Elderly Patients with COVID-19: Potential of Melatonin Treatment.
    Viruses, 2023, 01-04, Volume: 15, Issue:1

    Topics: Aged; COVID-19; Endoplasmic Reticulum Stress; Humans; Inflammasomes; Melatonin; SARS-CoV-2

2023
Role of Supplements in the Management of COVID-19 - A Comprehensive Review.
    Infectious disorders drug targets, 2023, Volume: 23, Issue:5

    Topics: COVID-19; Dietary Supplements; Humans; Melatonin; SARS-CoV-2; Selenium; Vitamin A; Vitamins

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach.
    Advances in experimental medicine and biology, 2023, Volume: 1412

    Topics: Antiviral Agents; COVID-19; Humans; Melatonin; Pelargonium; Phytotherapy; Plant Extracts; Plant Root

2023
Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis.
    Advances in medical sciences, 2023, Volume: 68, Issue:2

    Topics: COVID-19; Humans; Length of Stay; Melatonin

2023
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Anti-Inflammatory Agents; Antioxidants; Betacoronavirus;

2020
Melatonin: Roles in influenza, Covid-19, and other viral infections.
    Reviews in medical virology, 2020, Volume: 30, Issue:3

    Topics: Animals; Betacoronavirus; Biosynthetic Pathways; Circadian Rhythm; Circadian Rhythm Signaling Peptid

2020
Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment.
    Life sciences, 2020, Aug-01, Volume: 254

    Topics: Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; In

2020
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19.
    Life sciences, 2020, Aug-15, Volume: 255

    Topics: Activating Transcription Factor 6; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-

2020
Is melatonin deficiency a unifying pathomechanism of high risk patients with COVID-19?
    Life sciences, 2020, 09-01, Volume: 256

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Melatonin; Pandemics; Pneumonia, Viral; S

2020
The Role of Genetic Sex and Mitochondria in Response to COVID-19 Infection.
    International archives of allergy and immunology, 2020, Volume: 181, Issue:8

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Female; Humans; Male; Melatonin; Mitochondria; Pa

2020
Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19.
    European journal of pharmacology, 2020, Sep-05, Volume: 882

    Topics: Adjuvants, Immunologic; Antioxidants; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; C

2020
Matrix metallopeptidase 9 as a host protein target of chloroquine and melatonin for immunoregulation in COVID-19: A network-based meta-analysis.
    Life sciences, 2020, Sep-15, Volume: 257

    Topics: Angiotensin-Converting Enzyme 2; Antiviral Agents; Betacoronavirus; Chloroquine; Computational Biolo

2020
Melatonin potentials against viral infections including COVID-19: Current evidence and new findings.
    Virus research, 2020, 10-02, Volume: 287

    Topics: Antioxidants; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Host-Pathogen Int

2020
Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?
    Cellular and molecular neurobiology, 2022, Volume: 42, Issue:3

    Topics: Animals; Brain; Central Nervous System; Central Nervous System Agents; Central Nervous System Viral

2022
Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?
    Turkish journal of medical sciences, 2020, 10-22, Volume: 50, Issue:6

    Topics: Aged; Aging; Animals; Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug

2020
Melatonin's Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease.
    Biomolecules, 2020, 08-20, Volume: 10, Issue:9

    Topics: Adjuvants, Pharmaceutic; Animals; Anti-Inflammatory Agents; Antioxidants; Coronavirus Infections; CO

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed.
    Nutrients, 2020, Aug-24, Volume: 12, Issue:9

    Topics: Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infec

2020
Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147).
    Molecular biology reports, 2020, Volume: 47, Issue:10

    Topics: Adjuvants, Pharmaceutic; Animals; Antioxidants; Antiviral Agents; Basigin; Coronavirus Infections; C

2020
A systematic review of COVID-19 and obstructive sleep apnoea.
    Sleep medicine reviews, 2021, Volume: 55

    Topics: Comorbidity; Continuous Positive Airway Pressure; COVID-19; Diabetes Mellitus; Humans; Hypertension;

2021
Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19.
    Molecules (Basel, Switzerland), 2020, Sep-25, Volume: 25, Issue:19

    Topics: Coronavirus Infections; COVID-19; Drug Delivery Systems; Humans; Melatonin; Mitochondria; Pandemics;

2020
Artificial Light at Night (ALAN): A Potential Anthropogenic Component for the COVID-19 and HCoVs Outbreak.
    Frontiers in endocrinology, 2020, Volume: 11

    Topics: Animals; Chiroptera; Coronavirus Infections; COVID-19; Ecosystem; Environment; Humans; Light; Lighti

2020
Familiar Dermatologic Drugs as Therapies for COVID-19.
    Actas dermo-sifiliograficas, 2021, Volume: 112, Issue:2

    Topics: Androgen Antagonists; Antimalarials; Antioxidants; Antiparasitic Agents; Chloroquine; Cinchona; COVI

2021
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin.
    Pharmacology & therapeutics, 2021, Volume: 224

    Topics: Aged; Animals; Antioxidants; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Female; Huma

2021
Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc.
    Nutrients, 2021, Apr-12, Volume: 13, Issue:4

    Topics: Ascorbic Acid; C-Reactive Protein; COVID-19; COVID-19 Drug Treatment; Dietary Supplements; Humans; I

2021
Endocrine and metabolic aspects of COVID-19.
    Endokrynologia Polska, 2021, Volume: 72, Issue:3

    Topics: Aging; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme 2; COVID-19; Diabetes Mellitus; Hu

2021
Melatonin interferes with COVID-19 at several distinct ROS-related steps.
    Journal of inorganic biochemistry, 2021, Volume: 223

    Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; COVID-19; COVID-19 Drug Treatment; Cytokine Relea

2021
Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders.
    International journal of molecular sciences, 2021, Aug-11, Volume: 22, Issue:16

    Topics: COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytokines; Free Radical Scavengers; Humans; Me

2021

Trials

12 trials available for melatonin and 2019 Novel Coronavirus Disease

ArticleYear
Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial.
    Journal of medical virology, 2022, Volume: 94, Issue:1

    Topics: COVID-19; COVID-19 Drug Treatment; Female; Hospitalization; Humans; Intensive Care Units; Male; Mela

2022
The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022, Volume: 114

    Topics: Adult; COVID-19; Humans; Melatonin; Prospective Studies; SARS-CoV-2; Sepsis; Thrombosis; Treatment O

2022
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: COVID-19; Humans; Melatonin; SARS-CoV-2; Treatment Outcome

2023
Melatonin for prevention of acute kidney injury in patients treated with intravenous polymyxin B: a double-blind, placebo-controlled randomized clinical trial.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2023, Volume: 29, Issue:5

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; COVID-19; Double-Blind Method; Fema

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.
    Trials, 2020, Jun-03, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral; Antiviral Agents; Betacoronavirus; Ch

2020
A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protoc
    Trials, 2020, Aug-05, Volume: 21, Issue:1

    Topics: Administration, Intravenous; Betacoronavirus; Coronavirus Infections; COVID-19; Double-Blind Method;

2020
Clinical trial to test the efficacy of melatonin in COVID-19.
    Journal of pineal research, 2020, Volume: 69, Issue:3

    Topics: Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; In

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial.
    Trials, 2020, Oct-26, Volume: 21, Issue:1

    Topics: Adult; Betacoronavirus; Biomarkers; Case-Control Studies; Central Nervous System Depressants; Corona

2020
Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit: A structured summary of a study protocol for a randomized controlled trial.
    Trials, 2021, Mar-08, Volume: 22, Issue:1

    Topics: Antioxidants; Blood Gas Analysis; C-Reactive Protein; COVID-19; COVID-19 Drug Treatment; Ferritins;

2021
Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial.
    Archives of medical research, 2022, Volume: 53, Issue:1

    Topics: COVID-19; Double-Blind Method; Humans; Iran; Melatonin; SARS-CoV-2; Treatment Outcome

2022

Other Studies

51 other studies available for melatonin and 2019 Novel Coronavirus Disease

ArticleYear
Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2.
    Journal of pineal research, 2022, Volume: 72, Issue:1

    Topics: Acetamides; Animals; COVID-19; COVID-19 Drug Treatment; Indenes; Lung; Melatonin; Mice; Mice, Inbred

2022
Melatonin mitigates Chloroquine-induced defects in porcine immature Sertoli cells.
    Theriogenology, 2022, Jan-01, Volume: 177

    Topics: Animals; Apoptosis; Autophagy; Chloroquine; COVID-19; COVID-19 Drug Treatment; Male; Melatonin; Phos

2022
Melatonin: Revisited Role as Vaccine Adjuvant During Outbreaks of COVID-19 Caused by the Delta Variant.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2022, Volume: 17, Issue:3-4

    Topics: Adjuvants, Vaccine; COVID-19; Disease Outbreaks; Humans; Melatonin; SARS-CoV-2

2022
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients.
    Signal transduction and targeted therapy, 2022, 01-28, Volume: 7, Issue:1

    Topics: Amino Acids; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; F

2022
Ultrasensitive and highly selective "turn-on" fluorescent sensor for the detection and measurement of melatonin in juice samples.
    Chemosphere, 2022, Volume: 295

    Topics: COVID-19; Humans; Limit of Detection; Melatonin; Molecular Imprinting; Reproducibility of Results; S

2022
Melatonin does not reduce mortality in adult hospitalized patients with COVID-19: a multicenter retrospective observational study.
    Journal of travel medicine, 2022, 05-31, Volume: 29, Issue:3

    Topics: Adult; COVID-19; Hospitalization; Humans; Melatonin; Retrospective Studies; SARS-CoV-2

2022
Melatonin increased hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase: A hypothesis for treating anaemia, ischaemia, and covid-19.
    Clinical and experimental pharmacology & physiology, 2022, Volume: 49, Issue:6

    Topics: Anemia; COVID-19; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Melatonin; P

2022
[Pre-pandemic melatonin treatment for sleep disorders and COVID-19 infection. A retrospective cross-sectional study].
    Vertex (Buenos Aires, Argentina), 2022, Volume: XXXIII, Issue:155

    Topics: Adult; Aged; Aged, 80 and over; COVID-19; Cross-Sectional Studies; Humans; Melatonin; Middle Aged; P

2022
The CLASS Study (Circadian Light in Adolescence, Sleep and School): protocol for a prospective, longitudinal cohort to assess sleep, light, circadian timing and academic performance in adolescence.
    BMJ open, 2022, 05-10, Volume: 12, Issue:5

    Topics: Academic Performance; Adolescent; Australia; Child; Circadian Rhythm; COVID-19; Humans; Melatonin; P

2022
The impact of COVID-19 on sleep and circadian rhythm.
    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 2022, 07-08, Volume: 48, Issue:3

    Topics: Circadian Rhythm; COVID-19; Humans; Melatonin; Sleep

2022
MEL-Index: Estimation of Tissue Melatonin Levels Using Gene Expression Data.
    Methods in molecular biology (Clifton, N.J.), 2022, Volume: 2550

    Topics: Acetylserotonin O-Methyltransferase; COVID-19; Cytochrome P-450 Enzyme System; Gene Expression; Huma

2022
Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia.
    Scandinavian journal of clinical and laboratory investigation, 2023, Volume: 83, Issue:2

    Topics: Anxiety; COVID-19; Depression; Humans; Melatonin; Sleep Initiation and Maintenance Disorders

2023
Differences in the diurnal variation of salivary stress biomarkers during the coronavirus (COVID-19) pandemic between telecommuters and office workers.
    Neuro endocrinology letters, 2023, Mar-08, Volume: 44, Issue:1

    Topics: Adult; Biomarkers; Circadian Rhythm; COVID-19; Female; Humans; Hydrocortisone; Immunoglobulin A; Mal

2023
Angiotensin converting enzyme 2 gene expression and markers of oxidative stress are correlated with disease severity in patients with COVID-19.
    Molecular biology reports, 2023, Volume: 50, Issue:7

    Topics: Angiotensin-Converting Enzyme 2; Antioxidants; COVID-19; Gene Expression; Humans; Melatonin; Oxidati

2023
Melatonin and Cytokines Modulate Daily Instrumental Activities of Elderly People with SARS-CoV-2 Infection.
    International journal of molecular sciences, 2023, May-12, Volume: 24, Issue:10

    Topics: Activities of Daily Living; Aged; COVID-19; Humans; Interleukin-17; Interleukin-6; Melatonin; Qualit

2023
Bmal1 and Gut-lung axis in SARS-CoV-2 infection: New insight into the effects of melatonin on COVID-19 patients?
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 164

    Topics: COVID-19; Gastrointestinal Tract; Humans; Lung; Melatonin; RNA, Viral; SARS-CoV-2

2023
What a difference a year makes: Objective rest/activity patterns, circadian phase markers, and sleep quality before and during the COVID-19 pandemic.
    Sleep health, 2023, Volume: 9, Issue:4

    Topics: Circadian Rhythm; COVID-19; Female; Humans; Longitudinal Studies; Male; Melatonin; Pandemics; Sleep

2023
Variation in Twitter posts referencing pediatric sleep aids.
    Sleep health, 2023, Volume: 9, Issue:4

    Topics: Cannabidiol; Child; COVID-19; Humans; Melatonin; Pandemics; Sleep; Social Media

2023
Melatonin effects on sleep quality of COVID-19 patients: a protocol for systematic review and meta-analysis of randomised controlled trials with trial sequential analysis.
    BMJ open, 2023, 06-22, Volume: 13, Issue:6

    Topics: COVID-19; Humans; Melatonin; Meta-Analysis as Topic; Sleep Quality; Sleep Wake Disorders; Systematic

2023
Correspondence COVID-19: Melatonin as a potential adjuvant treatment.
    Life sciences, 2020, 07-15, Volume: 253

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Melatonin; Pandemics; Pneumonia, Viral; S

2020
Can melatonin reduce the severity of COVID-19 pandemic?
    International reviews of immunology, 2020, Volume: 39, Issue:4

    Topics: Age Factors; Aged; Aging; Animals; Antioxidants; Betacoronavirus; Chiroptera; Circadian Rhythm; Coro

2020
Comment on Melatonin as a potential adjuvant treatment for COVID-19.
    Life sciences, 2020, 07-15, Volume: 253

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Melatonin; Pandemics; Pneumonia, Viral; S

2020
Delirium and sleep disturbances in COVID-19: a possible role for melatonin in hospitalized patients?
    Sleep medicine, 2020, Volume: 70

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Delirium; Humans; Melatonin; Pandemics; Pneumonia

2020
Delirium, sleep, COVID-19 and melatonin.
    Sleep medicine, 2020, Volume: 75

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Delirium; Humans; Melatonin; Pandemics; Pneumonia

2020
Could melatonin be used in COVID-19 patients with laryngopharyngeal reflux disease?
    Journal of medical virology, 2021, Volume: 93, Issue:1

    Topics: China; COVID-19; Humans; Laryngopharyngeal Reflux; Melatonin; Retrospective Studies; SARS-CoV-2

2021
Effects of altered photoperiod due to COVID-19 lockdown on pregnant women and their fetuses.
    Chronobiology international, 2020, Volume: 37, Issue:7

    Topics: Betacoronavirus; Circadian Clocks; Circadian Rhythm; Coronavirus Infections; COVID-19; Female; Fetus

2020
Are night shift workers at an increased risk for COVID-19?
    Medical hypotheses, 2020, Volume: 144

    Topics: ARNTL Transcription Factors; Circadian Rhythm; COVID-19; Cytokines; Disease Susceptibility; DNA Repa

2020
Reply to 'Delirium, sleep, COVID-19 and melatonin'.
    Sleep medicine, 2020, Volume: 75

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Delirium; Humans; Melatonin; Pandemics; Pneumonia

2020
Melatonin as a putative protection against myocardial injury in COVID-19 infection.
    Expert review of clinical pharmacology, 2020, Volume: 13, Issue:9

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Heart Diseases; Humans; Melatonin; Pandemics; Pne

2020
Exogenous melatonin as potential adjuvant in anti-SarsCov2 vaccines.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2020, Volume: 15, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Antioxidants; COVID-19; COVID-19 Vaccines; Humans; Immunity; Melato

2020
COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease Inhibitor.
    International journal of medical sciences, 2020, Volume: 17, Issue:14

    Topics: Anti-Inflammatory Agents; Antioxidants; Betacoronavirus; Coronavirus 3C Proteases; Coronavirus Infec

2020
Melatonin: a fertility-friendly anti-coronavirus agent.
    Reproductive biomedicine online, 2020, Volume: 41, Issue:6

    Topics: Coronavirus; COVID-19; Fertility; Humans; Melatonin; Pandemics; Reproductive Health; SARS-CoV-2

2020
Clinical study of novel coronavirus pneumonia prevention by melatonin.
    Reproductive biomedicine online, 2020, Volume: 41, Issue:6

    Topics: COVID-19; Humans; Melatonin; Pandemics; Pneumonia; Reproductive Health; SARS-CoV-2

2020
In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm.
    PloS one, 2020, Volume: 15, Issue:10

    Topics: Antiviral Agents; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndro

2020
Global research trends at the intersection of coronavirus disease 2019 (COVID-19) and traditional, integrative, and complementary and alternative medicine: a bibliometric analysis.
    BMC complementary medicine and therapies, 2020, Nov-23, Volume: 20, Issue:1

    Topics: Betacoronavirus; Bibliometrics; Biomedical Research; China; Complementary Therapies; Coronavirus; Co

2020
New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment.
    Nanomedicine (London, England), 2020, Volume: 15, Issue:29

    Topics: COVID-19; COVID-19 Drug Treatment; Humans; Melatonin; Mitochondria; Nanostructures; Pandemics; SARS-

2020
Fluvoxamine, melatonin and COVID-19.
    Psychopharmacology, 2021, Volume: 238, Issue:2

    Topics: Clinical Deterioration; COVID-19; Fluvoxamine; Humans; Melatonin; Outpatients; SARS-CoV-2

2021
Daylight is critical to preserve 5-methoxytryptophol levels in suspected and confirmed COVID-19 patients.
    Medical hypotheses, 2021, Volume: 147

    Topics: Antioxidants; Circadian Rhythm; COVID-19; Cytokine Release Syndrome; Humans; Immune System; Indoles;

2021
Autism Spectrum Disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin.
    Medical hypotheses, 2021, Volume: 149

    Topics: Autism Spectrum Disorder; Circadian Rhythm; COVID-19; Disease Susceptibility; Genetic Variation; Hum

2021
Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections.
    Open heart, 2021, Volume: 8, Issue:1

    Topics: Antioxidants; COVID-19; COVID-19 Drug Treatment; Humans; Melatonin; Risk Factors; RNA Virus Infectio

2021
Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID-19.
    Journal of pineal research, 2021, Volume: 71, Issue:1

    Topics: Anti-Inflammatory Agents; COVID-19; COVID-19 Drug Treatment; Host-Pathogen Interactions; Humans; Mel

2021
Impact of COVID-19 on serum melatonin levels and sleep parameters in children
    Turkish journal of medical sciences, 2021, 08-30, Volume: 51, Issue:4

    Topics: Adolescent; Child; Cohort Studies; COVID-19; Cross-Sectional Studies; Female; Humans; Male; Melatoni

2021
Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin.
    Medical hypotheses, 2021, Volume: 151

    Topics: COVID-19; Humans; Inflammasomes; Melatonin; NLR Family, Pyrin Domain-Containing 3 Protein; Periodont

2021
Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment.
    European journal of pharmacology, 2021, Aug-05, Volume: 904

    Topics: Anti-Inflammatory Agents; COVID-19; COVID-19 Drug Treatment; Cytokines; Female; Humans; Immunity, Ce

2021
Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations.
    Journal of pineal research, 2021, Volume: 71, Issue:2

    Topics: Animals; Antiviral Agents; COVID-19; Humans; Melatonin; SARS-CoV-2; Swine; Swine Diseases

2021
Pediatric COVID-19 Delirium: Case Report of 2 Adolescents.
    WMJ : official publication of the State Medical Society of Wisconsin, 2021, Volume: 120, Issue:2

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Antipsychotic Agents; COVID-19; Delirium; Drug The

2021
Possible role of exogenous melatonin in preventing more serious COVID-19 infection in patients with type 2 diabetes mellitus.
    Revista da Associacao Medica Brasileira (1992), 2021, Volume: 67Suppl 1, Issue:Suppl 1

    Topics: COVID-19; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Melatonin; SARS-CoV-2

2021
In-person vs home schooling during the COVID-19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence.
    Journal of pineal research, 2021, Volume: 71, Issue:2

    Topics: Adolescent; Child; Circadian Rhythm; COVID-19; Humans; Melatonin; Pandemics; SARS-CoV-2; Sleep

2021
Molecular insight on the formation structure and dynamics of melatonin in an aqueous solution and at the Water-Air interface: A molecular dynamics study.
    Journal of molecular graphics & modelling, 2021, Volume: 108

    Topics: COVID-19; Humans; Melatonin; Molecular Dynamics Simulation; Molecular Structure; SARS-CoV-2; Water

2021
What if melatonin could help patients with severe COVID-19?
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022, 01-01, Volume: 18, Issue:1

    Topics: Antioxidants; COVID-19; Humans; Melatonin; SARS-CoV-2

2022
A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement.
    Iranian journal of allergy, asthma, and immunology, 2021, Aug-07, Volume: 20, Issue:4

    Topics: Adult; C-Reactive Protein; COVID-19; COVID-19 Drug Treatment; Dietary Supplements; Female; Humans; I

2021