melarsoprol has been researched along with Trypanosomiasis, African in 220 studies
*Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (28.18) | 18.7374 |
| 1990's | 48 (21.82) | 18.2507 |
| 2000's | 64 (29.09) | 29.6817 |
| 2010's | 43 (19.55) | 24.3611 |
| 2020's | 3 (1.36) | 2.80 |
| Authors | Studies |
|---|---|
| Cerami, A; Ulrich, P | 1 |
| Brun, R; Chowdhury, SF; Croft, SL; Gilbert, IH; Goodman, JM; Guerrero, RH; Leal, I; Maes, L; Pacanowska, DG; Ruiz-Perez, LM; Villamor, VB | 1 |
| Baliani, A; Barrett, MP; Brun, R; Bueno, GJ; Gilbert, IH; Stewart, ML; Yardley, V | 1 |
| Brun, R; Dardonville, C; García, RN; Kaiser, M; Nguyen, B; Rodríguez, F; Rozas, I; Wilson, WD | 1 |
| Brun, R; Heidler, P; Kaiser, M; Link, A | 1 |
| Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA | 1 |
| Boykin, DW; Brun, R; Hall, JE; Ismail, MA; Tidwell, RR; Wenzler, T | 1 |
| Delfín, DA; Fotie, J; Kaiser, M; Li, C; Maes, L; Mahasenan, KV; Manley, J; Paris, JM; Reid, CS; Wenzler, T; Werbovetz, KA | 1 |
| Brun, R; Jędrysiak, R; Kaiser, M; Suwiński, J; Torreele, E; Trunz, BB; Tweats, D | 1 |
| Bayliss, T; Brand, S; Brenk, R; Cleghorn, LA; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Hallyburton, I; Harrison, JR; McElroy, SP; Norcross, NR; Norval, S; Read, KD; Robinson, DA; Smith, VC; Spinks, D; Stojanovski, L; Torrie, LS; Wyatt, PG | 1 |
| Braunschweig, H; Damme, A; Engstler, M; Hiltensperger, G; Holzgrabe, U; Jones, NG; Jung, J; Kaiser, M; Meinel, L; Niedermeier, S; Puhl, S; Stich, A | 1 |
| Brun, R; Connelly, MC; Guy, RK; Holbrook, G; Hwang, JY; Kaiser, M; Smithson, D; Zhu, F | 1 |
| Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C | 1 |
| Almohaywi, B; Avery, VM; Baell, JB; Campbell, M; Charman, SA; Ferrins, L; Hyland, C; Jones, AJ; Kaiser, M; Rahmani, R; Ryan, E; Smith, J; Sykes, ML; Teston, E; White, KL; Yin, J | 1 |
| Bakunov, SA; Bakunova, SM; Brun, R; Patrick, DA; Tidwell, RR; Wenzler, T | 1 |
| Cal, M; Dong, Y; Kaiser, M; Vennerstrom, JL; Wang, X | 1 |
| Dardonville, C; Kaiser, M; Lagartera, L; Ríos Martínez, CH | 1 |
| Brantner, A; Brun, R; Bucar, F; Faist, J; Gröblacher, B; Kaiser, M; Kalia, Y; Merino, V; Perozzo, R; Saf, R; Scapozza, L; Seebacher, W; Weis, R; Wolkinger, V | 1 |
| Brun, R; Göker, H; Kaiser, M; Karaaslan, C | 1 |
| Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR | 1 |
| Brun, R; Calvet, CM; Costi, R; De Leo, A; De Vita, D; Di Santo, R; Jennings, GK; Kaiser, M; Madia, VN; Mäser, P; Messore, A; Pescatori, L; Podust, LM; Saccoliti, F; Scipione, L; Tudino, V | 1 |
| Arroo, RRJ; Bhambra, AS; Botana, A; Ellinger, B; Eurtivong, C; Gul, S; Kaiser, M; Kuzikov, M; Lauga-Cami, S; Robinson, WJ; Schirmeister, T; Singh, K; Taylor, AE; Weaver, GW | 1 |
| Al-Salabi, MI; Alghamdi, AH; Anderson, LF; Boykin, DW; Campagnaro, GD; Carrington, M; Dardonville, C; De Koning, HP; Dimitriou, A; Eze, AA; Field, M; Gudin, S; Gurvic, D; Hulpia, F; Ibrahim, HM; Kelly, SPY; Kumar, A; Martin Abril, ME; Milić, P; Munday, JC; O'Neill, P; Okpara, CE; Paape, D; Quintana, J; Settimo, L; Smart, G; Sprenger, T; Svensson, F; Teka, IA; Tidwell, RR; Watson, L; Weyand, S; Wielinska, J; Woodley, CM; Zachariae, U | 1 |
| Auma, JE; Chemuliti, JK; Gitonga, PK; Kurgat, RK; Mdachi, RE; Murilla, GA; Ndung'u, K; Ngae, GN; Thuita, JK; Thungu, DK | 1 |
| Baker, N; Horn, D; Jeacock, L; Mäser, P; Wiedemar, N | 1 |
| Rushworth, SA; Steverding, D | 1 |
| Fairlamb, AH; Horn, D | 1 |
| Kaka, JT; Kazumba, LM; Ngoyi, DM; Tshala-Katumbay, D | 1 |
| Alsford, S; Baker, N; Dominicus, C; Glover, L; Horn, D; Hutchinson, S; Thomas, JA; Trenaman, A | 1 |
| Kennedy, A; Lutje, V; Seixas, J | 2 |
| Boykin, DW; Braissant, O; Brun, R; Wang, MZ; Wenzler, T; Yang, S | 1 |
| Brun, R; Büscher, P; de Koning, HP; Graf, FE; Horn, D; Kaiser, M; Ludin, P; Mäser, P; Pyana, PP; Wenzler, T | 1 |
| Boykin, DW; Braissant, O; Brun, R; Ismail, MA; Patrick, DA; Tidwell, RR; Wang, MZ; Wenzler, T; Yang, S | 1 |
| Büscher, P; Karhemere Bin Shamamba, S; Mumba Ngoyi, D; Ngay Lukusa, I; Pyana Pati, P; Van Reet, N | 1 |
| Bradley, B; Burrell-Saward, H; Croft, SL; Rodgers, J; Ward, TH | 1 |
| Baloji, S; Boelaert, M; da Luz, RI; Hendrickx, D; Lumbala, C; Lutumba, P; Mpanya, A | 1 |
| Arquint, C; Baker, N; Balmer, O; Caccone, A; de Koning, HP; Graf, FE; Horn, D; Krezdorn, J; Kunz Renggli, C; Ludin, P; Mäser, P; Munday, JC; Schaub, N; Schmidt, RS | 1 |
| Betu Ku Mesu Kande, V; Boelaert, M; Lutumba, P; Nyamowala, G; Robays, J; Sese, C; Van der Veken, W | 1 |
| Balasegaram, M; Chappuis, F; Checchi, F; Priotto, G; Raguenaud, ME; Young, H | 1 |
| Kaboya, JS; Kibona, SN; Manga, C; Mbilu, TJ; Nkya, GM; Rawille, F; Sindato, C | 1 |
| De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA | 1 |
| Blum, J; Brun, R; Burri, C; Chappuis, F | 1 |
| Schlitzer, M | 1 |
| Boelaert, M; Büscher, P; Lejon, V; Ngoyi, DM | 1 |
| Al-Salabi, MI; Augustyns, K; Berg, M; Castagna, V; Cos, P; de Koning, HP; Degano, M; Giannese, F; Grellier, P; Haemers, A; Joossens, J; Kohl, L; Maes, L; Steyaert, J; Van der Veken, P; Versées, W | 1 |
| Barrett, MP | 2 |
| Farah, IO; Hau, J; Kagira, JM; Kariuki, C; Maina, N; Mwangangi, DM; Ngotho, M; Thuita, JK | 1 |
| Bandzouzi, B; Bouteille, B; Buguet, A; Cespuglio, R; Mpandzou, G; Ngampo, S; Vincendeau, P | 1 |
| Büscher, P; Kaiser, M; Karhemere Bin Shamamba, S; Mumba Ngoyi, D; Ngay Lukusa, I; Pyana, PP; Van Reet, N | 1 |
| Barat, C; Pepin, J; Tremblay, MJ | 1 |
| Barrett, MP; Bradley, B; Gettinby, G; Gibaud, S; Jones, A; Kennedy, PG; McCabe, C; Rodgers, J | 1 |
| Alsford, S; Baker, N; Berriman, M; Eckert, S; Field, MC; Glover, L; Horn, D; Leung, KF; Sanchez-Flores, A; Turner, DJ | 1 |
| Diarra, A; Franco, J; Jannin, J; Postigo, JA; Simarro, PP | 1 |
| Kennedy, PG | 1 |
| Bailey, R; Brown, M; Easom, N; Watson, J; Wise, E | 1 |
| Allan, M; Blum, J; Burri, C; Edielu, A; Haary, EP; Kakembo, A; Kibona, S; Kuepfer, I; Schmid, C | 1 |
| Baker, N; de Koning, HP; Horn, D; Mäser, P | 1 |
| Burri, C; Büscher, P; Gastellu-Etchegorry, M; Jannin, J; Legros, D; Ollivier, G; Paquet, C | 1 |
| Bradley, B; Gettinby, G; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J | 1 |
| Kager, PA | 1 |
| Kager, PA; Mendonça Melo, M; Rasica, M; Richter, C; van Thiel, PP; Wismans, PJ | 1 |
| Boa, F; Dje, NN; Doua, F; Miezan, TW | 1 |
| Nok, AJ | 1 |
| Barrett, MP; Krishna, S; Stich, A | 1 |
| Docampo, R; Moreno, SN | 1 |
| NEUJEAN, G | 1 |
| APTED, FI | 1 |
| PINTO, AR | 1 |
| CARMO, RP; CASEIRO, A; DE BASTO, AX; SILVA, MA | 1 |
| BURKE, J | 1 |
| NIXON, LC; TAUBE, E | 1 |
| ADRIA ENSSENS, K | 1 |
| JANSSENS, PG; MICHIELS, A; VAN BOGAERT, L; VAN DE STEEN, R | 1 |
| ROBERTSON, DH | 2 |
| Büscher, P; Etchegorry, MG; Legros, D; Lejon, V; Mbulamberi, D; Savignoni, A | 1 |
| Abel, PM; Behrend, M; Fleischmann, H; Kiala, G; Krishna, S; Lôa, V; Musolf, J; Stich, A; Théophile, J | 1 |
| FRIEDHEIM, EA | 1 |
| Bisser, S; Buguet, A; Cespuglio, R; Chapotot, F; Josenando, T | 1 |
| Asumu, PN; Bilenge, CM; Burri, C; Chappuis, F; Doua, F; Josenando, T; Manthelot, CR; Nangouma, A; Richer, M; Schmid, C; Simarro, PP | 1 |
| Mpia, B; Pépin, J | 2 |
| Bovier, PA; Chappuis, F; Meussen, A; Stietenroth, K; Udayraj, N | 1 |
| Blum, J; Burri, C; Schmid, C | 1 |
| Alibu, VP; Brun, R; Clayton, C; Marti, G; Renggli, CK; Richter, C; Seebeck, T; Shahi, S; Voncken, F | 1 |
| Kaboya, JS; Kibona, SN; Lubega, GW; Matemba, L | 1 |
| Berbari, EF; Klein, CJ; Kumar, N; Orenstein, R; Uslan, DZ; Windebank, AJ | 1 |
| Kibiki, GS; Murphy, DK | 1 |
| Franco, JR; Jannin, J; Louis, FJ; Ndongo, P; Nguema, E; Simarro, PP | 1 |
| Berbari, EF; Jacobson, KM; Kumar, N; Orenstein, R; Uslan, DZ | 1 |
| Bailey, W; Corrah, T; Faye, JA; Fleming, L; Greenwood, B; Guy, M; Howie, S; Molyneux, D; Noyes, H; Pepin, J; Whittle, H | 1 |
| Brun, R; Fomena, A; Likeufack, AC; Truc, P | 1 |
| Balasegaram, M; Checchi, F; Ghorashian, S; Hamel, C; Harris, S; Karunakara, U | 1 |
| Bisser, S; Būscher, P; Lejon, V; Miaka Mia Bilenge, C; N'Siesi, FX; Preux, PM; Van Nieuwenhove, S | 1 |
| Chappuis, F; Eperon, G; Loutan, L; Schmid, C | 1 |
| Checkley, AM; Gibson, WC; Jäger, HR; Mabey, DC; Pepin, J; Taylor, MN | 1 |
| Boelaert, M; Kande Betu Ku Mesu, V; Lefèvre, P; Lubanza, S; Lutumba, P; Robays, J; Van der Stuyft, P | 1 |
| Abel, PM; Krishna, S; Woodrow, CJ | 1 |
| Bradley, B; Kennedy, PG; Rodgers, J | 1 |
| Kagira, JM; Maina, N | 1 |
| Chappuis, F | 1 |
| Enyaru, JC; Lubega, GW; Matovu, E; Nerima, B | 1 |
| Blum, JA; Burri, C; Hatz, C; Kazumba, L; Mangoni, P; Zellweger, MJ | 1 |
| Boelaert, M; Josenando, T; Raguenaud, ME; Robays, J | 1 |
| Bisser, S; Boelaert, M; Büscher, P; Lejon, V; Menten, J; Mumba Ngoyi, D; N'siesi, FX; Robays, J; Roger, I | 1 |
| Hochmann, A; Lambert, PH; Poltera, AA | 2 |
| Dukes, P | 1 |
| Gasbarre, LC; Hug, K; Louis, J | 1 |
| Breton, JC; Catanzano, G; Dumas, M; Nicolas, JA; Pestre-Alexandre, M | 1 |
| Foulkes, JR | 2 |
| Poltera, AA | 2 |
| Hall, JE; Seed, JR; Shertzer, HG | 1 |
| Boa Yapo, F; Doua, F | 1 |
| Ancelle, T; Barret, B; Flachet, L; Moren, A | 1 |
| Bert, J; Bogui, P; Buguet, A; Doua, F; Gati, R; Mouanga, G; Sarda, J; Stanghellini, A; Tabaraud, F; Tapie, P | 1 |
| Brosset, C; Buguet, A; Imbert, P; Montmayeur, A | 1 |
| Bronner, U; Doua, F; Ericsson, O; Gustafsson, LL; Miézan, T; Rais, M; Rombo, L | 1 |
| Roberts, JF; Yunmbam, MK | 1 |
| Dumas, M | 2 |
| Blum, J; Brun, R; Burri, C | 1 |
| Bruneel, H; Burke, J; Degroof, D; Molisho, D; Pépin, J; van den Eeckhout, A | 1 |
| Gichuki, CW; Nantulya, VM; Sayer, PD | 1 |
| Doua, F; Yapo, FB | 1 |
| Jennings, FW | 2 |
| Dadzie, S; Kimata, DM; Makawiti, DW; Tengekyon, KM; Waindi, EN | 1 |
| Burkardt, H; Damian, MS; Dorndorf, W; Leinweber, B; Schachenmayr, W; Singer, I | 1 |
| Milord, F; Pépin, J | 1 |
| Kazadi, K; Kazumba, M; Mulumba, MP | 1 |
| Bruneel, H; De Groof, D; Mungoma, K; Ruppol, JF | 1 |
| Brun, R; Iten, M; Kaminsky, R; Matovu, E | 1 |
| Chauvière, G; Jennings, FW; Murray, M; Viode, C | 1 |
| Atouguia, JM; Jennings, FW; Murray, M | 2 |
| Bronner, U; Ericsson, O; Fridén, M; Gustafsson, LL; Rombo, L; Schweda, EK | 1 |
| Alafiatayo, RA; Barclay, GR; Crawley, B; Doua, F; Oppenheim, BA; Pentreath, VW | 1 |
| Buguet, A; Dumas, M; Muanga, G; Radomski, MW; Rhind, SG; Sabiston, BH; Shek, PN; Stanghellini, A | 1 |
| Bales, JD; Harris, RW; Harrison, SM | 1 |
| Cattand, P; Jannin, J | 1 |
| Bamba, M; Coulibaly, S; Doua, F; Miezan, TB; Youan, BB | 1 |
| Bonardel, G; Briant, JF; Brosset, C; Imbert, P; Jeandel, P; Sabbah, P | 1 |
| Bouteille, B; Dumas, M | 2 |
| Lastre González, M; Pérez Martín, O; Shwalbach, J; Urban, M | 1 |
| Boa, YF; Bronner, U; Brun, R; Burri, C; Doua, F; Ericsson, O; Gustafsson, LL; Keiser, J; Miézan, TW; Rombo, L | 1 |
| Buguet, A | 1 |
| Fournier, C; Gastellu Etchegorry, M; Legros, D; Maiso, F; Szumilin, E | 1 |
| Bert, J; Buguet, A; Tapie, P | 1 |
| Gastellu, M; Pécoul, B | 1 |
| Boken, D; Malesker, MA; Murphy, PJ; Ruma, TA; Smith, PW; Vuchetich, PJ | 1 |
| Cuny, G; Frézil, JL; Jamonneau, V; Truc, P | 1 |
| Alston, WK; Grace, C; Maguire, JH; Sinha, A; Westenfeld, F | 1 |
| Hirumi, H; Hirumi, K; Inoue, N; Mbati, PA; Situakibanza, NH | 2 |
| Barrett, MP; Barrett, SV | 1 |
| Bonkoungou, P; Millogo, A; Nacro, B; Sanou, M; Tall, F; Traoré, H; Traoré, S | 1 |
| Blum, J; Brun, R; Burri, C; Merolle, A; Nkunku, S; Smith, T | 1 |
| Simon, F | 1 |
| Burri, C; Ericsson, O; Keiser, J | 1 |
| Blum, J; Burri, C; Nkunku, S | 1 |
| Enyaru, JC; Kaminsky, R; Legros, D; Matovu, E; Schmid, C; Seebeck, T | 1 |
| Burri, C; Keiser, J | 1 |
| Enyaru, JC; Gallati, S; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Schneider, V; Seebeck, T | 1 |
| Legros, D; Ollivier, G | 1 |
| Brun, R; Burri, C; Kunz, C; Schmid, C; Schumacher, R | 1 |
| Etchegorry, MG; Helenport, JP; Jannin, J; Legros, D; Pecoul, B | 1 |
| McNeil, DG | 1 |
| Blum, J; Burri, C | 1 |
| Jennings, F; Kennedy, PG; Murray, M; Rodgers, J | 1 |
| Aiyedun, BA; Amodu, AA | 2 |
| Williamson, J | 1 |
| Charmot, G; Dupont, B; Lapresle, C | 1 |
| Basson, W; Myburgh, DP; Page, ML | 1 |
| Greenwood, BM; Whittle, HC | 1 |
| Brodsky, RE; Gibson, JJ; Schultz, MG; Spencer, HC | 1 |
| Buyst, H | 1 |
| Buyst, H; Jones, IG; Lowenthal, MN | 1 |
| Brun, R; Burri, C | 1 |
| Golden, MH | 1 |
| Van Nieuwenhove, S | 1 |
| Bacchi, CJ; Garofalo, J; Goldberg, B; Nathan, HC; Yarlett, N | 1 |
| Mateo, MJ; Mir, M; Roche, J; Sima, FO; Simarro, PP | 1 |
| Camara, P; Hamon, JF | 1 |
| Ormerod, WE; Raseroka, BH | 1 |
| Bales, JD; Harrison, SM; Mbwabi, DL; Schecter, PJ | 1 |
| Ethier, L; Guern, C; Mansinsa, D; Milord, F; Mpia, B; Pepin, J | 1 |
| Thomson, KD | 1 |
| Baeriswyl, S; Brun, R; Kunz, C | 1 |
| Chumo, DA; Muriithi, RM; Mwangi, J; Reardon, MJ; Towett, S; Wellde, BT | 1 |
| Abinya, A; Chumo, DA; Dola, S; Mbwabi, D; Reardon, MJ; Siongok, TA; Smith, DH; Wanyama, L; Wellde, BT | 1 |
| Dolmans, WM; Ebeling, MC; Veeken, HJ | 1 |
| Guern, C; Milord, F; Pepin, J; Schechter, PJ | 1 |
| Bouteille, B; Darde, ML; Pestre-Alexandre, M | 1 |
| Kazyumba, GL; Nkanga, N; Ruppol, JF; Tshefu, AK | 1 |
| Breton, JC; Dumas, M; Giordano, C; Girard, PL; Pestre Alexandre, M | 1 |
| Gutteridge, WE | 1 |
| Frommel, TO | 1 |
| Akani, F; Boa, FY; Giordano, C; Kouassi, B; Piquemal, M; Sonan, T; Yapi, P | 1 |
| Bouteille, B; Darde, ML; Monteil, J; Pestre-Alexandre, M | 1 |
| Bouteille, B; Breton, JC; Catanzano, G; Darde, ML; Dumas, M; Munoz, M; Nicolas, JA; Pestre-Alexandre, M | 1 |
| Kernbaum, S; Pialoux, G; Vachon, F | 1 |
| Cattand, P; Doua, F; Hamers, R; Maes, L; Vanderveken, M | 1 |
| Brucher, JM; Chirimwami, B; Gigase, PL; Van Marck, EA; Wery, M | 1 |
| Scena, MR | 1 |
| Corachán, M; Estruch, R; Grau Junyent, JM; Rozman, M; Urbano-Marquez, A | 1 |
| Arroz, JO | 1 |
| van der Meer, C; Versluijs-Broers, JA | 1 |
| Champalimaud, JL; Medina, EA; Ventura, FA | 1 |
| Agbowu, J; Ajayi, N; Weir, AB | 1 |
| Wu, SH | 1 |
| Adams, H; Dago, A; Haller, L; Merouze, F | 1 |
19 review(s) available for melarsoprol and Trypanosomiasis, African
| Article | Year |
|---|---|
Melarsoprol Resistance in African Trypanosomiasis.
Topics: Aquaglyceroporins; Drug Resistance; Humans; Melarsoprol; Mutation; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2018 |
Chemotherapy for second-stage human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2013 |
[Agents for the treatment of African sleeping sickness. Those developed in the last century].
Topics: Animals; Eflornithine; History, 20th Century; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 2009 |
Chemotherapy for second-stage Human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2010 |
Potential new drugs for human African trypanosomiasis: some progress at last.
Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis.
Topics: Animals; Drug Therapy, Combination; Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African | 2012 |
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.
Topics: Animals; Aquaglyceroporins; Drug Resistance; Humans; Melarsoprol; Pentamidine; Phylogeny; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
Treatment of human African trypanosomiasis--present situation and needs for research and development.
Topics: Africa South of the Sahara; Animals; Benzamidines; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Thiadiazoles; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2002 |
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.
Topics: Animals; Drug Resistance; HIV; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2003 |
Waking up to sleeping sickness.
Topics: Africa South of the Sahara; Animals; Communicable Diseases, Emerging; Disease Outbreaks; Humans; Insect Vectors; Melarsoprol; Orphan Drug Production; Pest Control, Biological; Trypanocidal Agents; Trypanosomiasis, African; Tsetse Flies | 2003 |
Current chemotherapy of human African trypanosomiasis.
Topics: Animals; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 2003 |
Human trypanosomiasis in the Ivory Coast: therapy and problems.
Topics: Animals; Cote d'Ivoire; Eflornithine; Humans; Melarsoprol; Pentamidine; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1993 |
Combination chemotherapy of CNS trypanosomiasis.
Topics: Arsenicals; Central Nervous System Diseases; Drug Therapy, Combination; Humans; Melarsoprol; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1993 |
The treatment of human African trypanosomiasis.
Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1994 |
African trypanosomiasis in two travelers from the United States.
Topics: Female; Humans; Male; Melarsoprol; Middle Aged; Travel; Trypanosomiasis, African | 1999 |
[Sleeping sickness, a reemerging sickness].
Topics: Africa; Animals; Communicable Diseases, Emerging; Disease Reservoirs; Humans; Mass Screening; Melarsoprol; Population Surveillance; Protozoan Vaccines; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis, African; Vaccination | 2000 |
Treatment of late stage sleeping sickness caused by T.b. gambiense: a new approach to the use of an old drug.
Topics: Animals; Clinical Trials as Topic; Drug Administration Schedule; Humans; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
Chemotherapy of African trypanosomiasis.
Topics: Adult; Amidines; Animals; Cattle; Drug Resistance; Drug Therapy, Combination; Humans; Melarsoprol; Phenanthridines; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African; Trypanosomiasis, Bovine | 1976 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1985 |
16 trial(s) available for melarsoprol and Trypanosomiasis, African
| Article | Year |
|---|---|
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.
Topics: Agglutination Tests; Antibodies, Protozoan; Eflornithine; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2010 |
Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage Rhodesiense sleeping sickness.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Drug Administration Schedule; Endemic Diseases; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Tanzania; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda | 2012 |
Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine.
Topics: Adolescent; Adult; Animals; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Female; Humans; Immunoglobulin M; Latex Fixation Tests; Leukocyte Count; Male; Melarsoprol; Middle Aged; Pentamidine; Recurrence; Risk Factors; Treatment Failure; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2003 |
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Male; Melarsoprol; Middle Aged; Time Factors; Trypanocidal Agents; Trypanosomiasis, African | 2005 |
Clinical aspects of 2541 patients with second stage human African trypanosomiasis.
Topics: Adolescent; Adult; Animals; Central Nervous System Protozoal Infections; Child; Child, Preschool; Female; Headache; Humans; Incidence; Infant; Internationality; Lymphatic Diseases; Male; Melarsoprol; Prospective Studies; Pruritus; Surveys and Questionnaires; Trypanocidal Agents; Trypanosomiasis, African | 2006 |
Randomized controlled trial of three regimens of melarsoprol in the treatment of Trypanosoma brucei gambiense trypanosomiasis.
Topics: Adolescent; Adult; Animals; Drug Administration Schedule; Female; Humans; Leukocyte Count; Lymph Nodes; Male; Melarsoprol; Proportional Hazards Models; Recurrence; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Adult; Animals; Brain Diseases; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Melarsoprol; Nifurtimox; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis).
Topics: Adult; Animals; Eflornithine; Electrocardiography; Female; Heart Diseases; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Novel markers for treatment outcome in late-stage Trypanosoma brucei gambiense trypanosomiasis.
Topics: Animals; Antibodies, Protozoan; Biomarkers; Cerebrospinal Fluid; Humans; Immunoglobulin M; Interleukin-10; Leukocyte Count; Melarsoprol; Predictive Value of Tests; Proteins; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2008 |
Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness.
Topics: Adult; Aged; Animals; Biomarkers; Blood Pressure; Drug Therapy, Combination; Female; Follow-Up Studies; Half-Life; Humans; Infusions, Intravenous; Male; Melarsoprol; Metabolic Clearance Rate; Pentamidine; Tissue Distribution; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1995 |
Attempt to correlate urine arsenic excretion with clinical course during melarsoprol therapy of patients with Rhodesian trypanosomiasis.
Topics: Adolescent; Adult; Aged; Animals; Arsenic; Child; Child, Preschool; Creatinine; Drug Therapy, Combination; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1997 |
Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial.
Topics: Adult; Angola; Animals; Brain Diseases; Drug Administration Schedule; Female; Humans; Injections, Intramuscular; Length of Stay; Male; Melarsoprol; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2000 |
Clinical description of encephalopathic syndromes and risk factors for their occurrence and outcome during melarsoprol treatment of human African trypanosomiasis.
Topics: Adult; Angola; Central Nervous System Protozoal Infections; Drug Administration Schedule; Female; Humans; Male; Melarsoprol; Middle Aged; Predictive Value of Tests; Risk Factors; Syndrome; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2001 |
Treatment of late stage sleeping sickness caused by T.b. gambiense: a new approach to the use of an old drug.
Topics: Animals; Clinical Trials as Topic; Drug Administration Schedule; Humans; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness.
Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Arsenicals; Child; Child, Preschool; Clinical Trials as Topic; Coma; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leukocyte Count; Male; Melarsoprol; Middle Aged; Prednisolone; Prognosis; Prospective Studies; Random Allocation; Sex Factors; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1989 |
[Current status of the therapy of human African trypanosomiasis].
Topics: Animals; Arsenicals; Clinical Trials as Topic; Glycolysis; Humans; Lipid Metabolism; Melarsoprol; Proteins; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African; Vaccines | 1985 |
186 other study(ies) available for melarsoprol and Trypanosomiasis, African
| Article | Year |
|---|---|
Potential antitrypanosomal agents. 1,N2-Disubstituted 2-amino-5-hydroxy-4-methylnaphtho[1,2-d]thiazolium salts and related compounds.
Topics: Animals; Chemical Phenomena; Chemistry; Female; Mice; Rats; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1982 |
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
Topics: Animals; Drug Design; Folic Acid Antagonists; Humans; In Vitro Techniques; Leishmania infantum; Leishmania major; Macrophages, Peritoneal; Mice; Models, Molecular; Tetrahydrofolate Dehydrogenase; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 1999 |
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
Topics: Animals; Cell Line; Female; Furaldehyde; Hydrazones; Leishmania donovani; Mice; Nitrofurans; Nucleoside Transport Proteins; Rats; Thiophenes; Triazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2005 |
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship; Transition Temperature; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2008 |
Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites.
Topics: Adenosine; Animals; Inhibitory Concentration 50; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
Topics: Animals; Antiprotozoal Agents; Benzene; Cell Survival; Leishmania donovani; Mice; Myoblasts; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
Topics: Animals; Benzamidines; Central Nervous System; Female; Furans; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |
Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.
Topics: Acetates; Animals; Cells, Cultured; Esters; Humans; Mice; Molecular Structure; Myoblasts; Quinolines; Rats; Reactive Oxygen Species; Structure-Activity Relationship; Survival Rate; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2010 |
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Mice; Molecular Structure; Mutagenicity Tests; Nitroimidazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanosomiasis, African | 2011 |
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
Topics: Acyltransferases; Administration, Oral; Aminopyridines; Animals; Cell Line; Cell Survival; Crystallography, X-Ray; Databases, Factual; Humans; Models, Molecular; Molecular Conformation; Parasitic Sensitivity Tests; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2012 |
Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei.
Topics: Acute Disease; Animals; Cell Line; DNA Topoisomerases, Type II; DNA, Kinetoplast; Mice; Microscopy, Fluorescence; Mitochondria; Models, Molecular; Morpholines; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2012 |
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Topics: Animals; Benzamides; Cell Line; Drug Evaluation, Preclinical; Humans; Structure-Activity Relationship; Trypanosomiasis, African | 2013 |
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; ErbB Receptors; Humans; Indicators and Reagents; Lapatinib; Morpholines; Neglected Diseases; Phosphotransferases; Quinazolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
Topics: Anilides; Animals; Humans; Mice; Myoblasts, Skeletal; Rats; Species Specificity; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Isoxazoles; Mice; Molecular Structure; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Trypanosomiasis, African | 2014 |
Activity of diimidazoline amides against African trypanosomiasis.
Topics: Amides; Animals; Disease Models, Animal; Humans; Imidazolines; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 2014 |
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.
Topics: Animals; Antiparasitic Agents; Benzamides; Binding Sites; Cell Line; Cell Survival; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Female; Guanidines; Mice; Mice, Inbred Strains; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Surface Plasmon Resonance; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Urea | 2014 |
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Azabicyclo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship; Tissue Distribution; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2015 |
Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Topics: Aniline Compounds; Animals; Antiprotozoal Agents; Benzimidazoles; Cell Line; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2016 |
Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.
Topics: Acetamides; Animals; Mice; Nitroreductases; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis, African | 2016 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis, Visceral; Malaria, Falciparum; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2018 |
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines.
Topics: Animals; Cell Line; Drug Discovery; Humans; Models, Molecular; Pyrimidines; Rats; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2021 |
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter
Topics: Animals; Aquaporin 2; Aquaporins; Drug Resistance; Melarsoprol; Mutation; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2020 |
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentamidine; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda; Virulence | 2020 |
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.
Topics: Animals; Aquaglyceroporins; Biological Transport; Disease Models, Animal; Drug Resistance; Gene Knockout Techniques; Glycerol; Melarsoprol; Mice; Mice, Inbred BALB C; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2017 |
Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Eflornithine; Glioblastoma; HL-60 Cells; Humans; Melarsoprol; Temozolomide; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo.
Topics: Adolescent; Adult; Democratic Republic of the Congo; Disease Management; Drug Therapy, Combination; Eflornithine; Female; Hospital Records; Humans; Male; Melarsoprol; Middle Aged; Multivariate Analysis; Nifurtimox; Recurrence; Retrospective Studies; Risk Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult | 2018 |
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
Topics: Cell Biology; Humans; Lysosomes; Melarsoprol; Mitochondria; Mitochondrial Proteins; Mitosis; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2018 |
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.
Topics: Amidines; Animals; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Humans; Injections, Intraperitoneal; Melarsoprol; Mice; Parasitic Sensitivity Tests; Pentamidine; Time Factors; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2013 |
Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.
Topics: Aquaporin 2; DNA, Protozoan; Drug Resistance; Humans; Melarsoprol; Molecular Sequence Data; Mutation; Pentamidine; Protozoan Proteins; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2013 |
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.
Topics: Amidines; Animals; Dose-Response Relationship, Drug; Female; Humans; Melarsoprol; Mice; Pentamidine; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2014 |
Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo.
Topics: Adult; Animals; Aquaglyceroporins; Base Sequence; Democratic Republic of the Congo; DNA, Protozoan; Drug Resistance; Female; Genotype; Humans; Melarsoprol; Mice; Molecular Sequence Data; Mutant Chimeric Proteins; Mutation; Pentamidine; Phenotype; Recurrence; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2014 |
A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.
Topics: Animals; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Luminescent Measurements; Melarsoprol; Mice; Parasite Load; Reproducibility of Results; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2015 |
From health advice to taboo: community perspectives on the treatment of sleeping sickness in the Democratic Republic of Congo, a qualitative study.
Topics: Animals; Democratic Republic of the Congo; Focus Groups; Humans; Male; Melarsoprol; Middle Aged; Qualitative Research; Taboo; Trypanocidal Agents; Trypanosomiasis, African | 2015 |
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.
Topics: Amino Acid Sequence; Aquaporins; Comparative Genomic Hybridization; DNA, Protozoan; Drug Resistance; Genome, Protozoan; Heterozygote; Humans; Male; Melarsoprol; Nucleoside Transport Proteins; Parasitic Sensitivity Tests; Pentamidine; Phenotype; Polymorphism, Single Nucleotide; Protozoan Proteins; RNA-Binding Proteins; Sequence Alignment; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2016 |
High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Democratic Republic of the Congo; Female; Humans; Infant; Male; Melarsoprol; Middle Aged; Recurrence; Treatment Failure; Trypanocidal Agents; Trypanosomiasis, African | 2008 |
Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angola; Animals; Child; Developing Countries; Eflornithine; Female; Humans; International Agencies; Male; Melarsoprol; Middle Aged; Statistics as Topic; Sudan; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda; Voluntary Health Agencies; Young Adult | 2009 |
Challenges in the diagnosis and management of sleeping sickness in Tanzania: a case report.
Topics: Adult; Animals; Diagnosis, Differential; Humans; Male; Melarsoprol; Tanzania; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2008 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Disease Models, Animal; Drug Interactions; Eflornithine; Indomethacin; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nifurtimox; Pentamidine; Perfusion; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 2009 |
Human African trypanosomiasis.
Topics: Africa; Animals; Biomedical Research; Communicable Disease Control; Eflornithine; Endemic Diseases; Humans; Incidence; Insect Bites and Stings; Insect Vectors; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies; Variant Surface Glycoproteins, Trypanosoma | 2010 |
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.
Topics: Adenosine; Animals; Antiprotozoal Agents; Carrier Proteins; Gene Knockdown Techniques; Melarsoprol; Mice; Models, Chemical; N-Glycosyl Hydrolases; Pentamidine; RNA, Small Interfering; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense.
Topics: Anemia, Macrocytic; Animals; Blood Platelets; Cerebrospinal Fluid; Chlorocebus aethiops; Diminazene; Disease Models, Animal; Female; Hematology; Leukocytes; Male; Melarsoprol; Thrombocytopenia; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2011 |
Polysomnography as a diagnosis and post-treatment follow-up tool in human African trypanosomiasis: a case study in an infant.
Topics: Arsenic Poisoning; Child, Preschool; Congo; Female; Humans; Melarsoprol; Polysomnography; Sleep Wake Disorders; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2011 |
Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice.
Topics: Adaptation, Biological; Animals; Antiprotozoal Agents; Blood; Cerebrospinal Fluid; Female; Humans; Male; Melarsoprol; Mice; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2011 |
HIV-1 replication in monocyte-derived dendritic cells is stimulated by melarsoprol, one of the main drugs against human African trypanosomiasis.
Topics: APOBEC-3G Deaminase; Cell Differentiation; Cytidine Deaminase; Dendritic Cells; Gene Expression Regulation, Viral; HEK293 Cells; HIV-1; HIV-2; Humans; Interferon-alpha; Melarsoprol; Monocytes; Trypanosomiasis, African; Up-Regulation; Virus Replication | 2011 |
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
Topics: Administration, Oral; Africa South of the Sahara; Animals; Antiprotozoal Agents; Blood-Brain Barrier; Brain; Cyclodextrins; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Male; Melarsoprol; Mice; Models, Molecular; Molecular Structure; Parasite Load; Parasitic Sensitivity Tests; Radiography; Treatment Outcome; Trypanosoma brucei brucei; Trypanosomiasis, African | 2011 |
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Topics: Aquaglyceroporins; Drug Resistance; Eflornithine; Endocytosis; Glycosylation; High-Throughput Screening Assays; Humans; Lysosomes; Melarsoprol; Nifurtimox; Pentamidine; RNA Interference; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2012 |
An alternative form of melarsoprol in sleeping sickness.
Topics: Administration, Oral; Animals; Clinical Trials as Topic; Humans; Infusion Pumps; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2012 |
Lesson of the month: a psychiatric diagnosis overturned by a blood film.
Topics: Antibodies, Protozoan; Cerebrospinal Fluid; Diagnosis, Differential; Female; Humans; Melarsoprol; Mental Disorders; Middle Aged; Parasitemia; Paresthesia; Spinal Puncture; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2012 |
Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen.
Topics: Animals; Anti-Infective Agents, Local; Drug Synergism; Drug Therapy, Combination; Female; Humans; Melarsoprol; Mice; Parasitemia; Suramin; Time Factors; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2002 |
[The return of sleeping sickness in an epidemic form: international action for drugs].
Topics: Africa, Central; Animals; Disease Outbreaks; Eflornithine; Humans; International Cooperation; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
[Three patients with African sleeping sickness following a visit to Tanzania].
Topics: Africa; Animals; Fatal Outcome; Female; Humans; Male; Melarsoprol; Middle Aged; Netherlands; Recurrence; Tanzania; Travel; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2002 |
[Human African trypanosomiasis in Ivory Coast: biological characteristics after treatment. 812 cases treated in the Daloa focus (Ivory Coast)].
Topics: Animals; Antibodies, Protozoan; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Cote d'Ivoire; Follow-Up Studies; Humans; Melarsoprol; Recurrence; Severity of Illness Index; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
[Use of arsobal in the treatment of sleeping sickness].
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1952 |
The treatment of advanced cases of Rhodesian sleeping sickness by Mel. B. and arsobal.
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1953 |
The therapeutic effect on a group of sleeping sickness patients of a single injection of 3854 R.P. (mel B Friedheim-arsobal Spécia).
Topics: Animals; Arsenicals; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1954 |
Arsobal in the treatment of Rhodesian sleeping-sickness.
Topics: Animals; Arsenicals; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1954 |
[Study of the therapeutic value of arsobal in trypanosomiasis caused by Trypanosoma gambiense].
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis; Trypanosomiasis, African | 1957 |
The treatment of advanced trypanosomiasis rhodesiense with mel B.
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1958 |
[Note on the toxicity of MEL B in Trypanosoma rhodesiense sleeping sickness].
Topics: Animals; Black People; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African | 1960 |
[African trypanosomiasis, virus disease, Mel B and encephalitis].
Topics: Animals; Arsenic Poisoning; Coxsackievirus Infections; Encephalitis; Enterovirus; Humans; Infections; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African; Virus Diseases | 1960 |
The treatment of sleeping sickness (mainly due to Trypanosoma rhodesiense) with melarsoprol. I. Reactions observed during treatment.
Topics: Animals; Arsenicals; Dimercaprol; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African | 1963 |
The treatment of sleeping sickness (mainly due to Trypanosoma rhodesiense) with melarsoprol.
Topics: Animals; Arsenicals; Dimercaprol; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African | 1963 |
Retaking sleeping sickness control in Angola.
Topics: Adolescent; Adult; Age Distribution; Aged; Angola; Animals; Child; Child, Preschool; Disease Outbreaks; Eflornithine; Female; Humans; Infant; Insect Vectors; Male; Melarsoprol; Middle Aged; Pentamidine; Sex Distribution; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies | 2004 |
Mel B in the treatment of tryparsamide resistant T. gambiense sleeping sickness: observations on drug resistance in the trypanosomes of the French Cameroun.
Topics: Animals; Arsenic; Arsenicals; Drug Resistance; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1951 |
Sleep structure: a new diagnostic tool for stage determination in sleeping sickness.
Topics: Adolescent; Adult; Animals; Child; Female; Humans; Male; Melarsoprol; Polysomnography; Sleep; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2005 |
Trypanosomiasis relapse after melarsoprol therapy, Democratic Republic of Congo, 1982-2001.
Topics: Adolescent; Adult; Animals; Democratic Republic of the Congo; Female; Humans; Male; Melarsoprol; Middle Aged; Secondary Prevention; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2005 |
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis.
Topics: Adolescent; Adult; Child; Eflornithine; Female; Humans; Male; Melarsoprol; Sudan; Trypanocidal Agents; Trypanosomiasis, African | 2005 |
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
Topics: Animals; Arsenicals; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Humans; Melarsoprol; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2006 |
Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.
Topics: Animals; Diminazene; Drug Resistance; Humans; Mass Screening; Melarsoprol; Phenanthridines; Recurrence; Suramin; Tanzania; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2006 |
Melarsoprol-associated multifocal inflammatory CNS illness in African trypanosomiasis.
Topics: Anti-Inflammatory Agents; Female; Humans; Inflammation; Melarsoprol; Methylprednisolone; Middle Aged; Paresthesia; Trypanocidal Agents; Trypanosomiasis, African | 2006 |
Transverse myelitis due to trypanosomiasis in a middle aged Tanzanian man.
Topics: Animals; Developing Countries; Drug Therapy, Combination; Follow-Up Studies; Humans; Male; Melarsoprol; Middle Aged; Myelitis, Transverse; Neurologic Examination; Radiculopathy; Spinal Cord Compression; Suramin; Tanzania; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2006 |
The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea.
Topics: Agglutination Tests; Animals; Disease Outbreaks; Disease Vectors; Endemic Diseases; Equatorial Guinea; Fluorescent Antibody Technique, Indirect; Humans; Melarsoprol; Pentamidine; Population Surveillance; Prevalence; Recurrence; Rural Health; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
A woman with fever and rash after African safari.
Topics: Africa; Exanthema; Female; Fever; Humans; Melarsoprol; Middle Aged; Pentamidine; Suramin; Travel; Trypanocidal Agents; Trypanosomiasis, African | 2006 |
A Gambian infant with fever and an unexpected blood film.
Topics: Animals; Edema; Female; Fever; Gambia; Humans; Infant; Melarsoprol; Parasitemia; Treatment Outcome; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis, African | 2006 |
Comparison of the in vitro drug sensitivity of Trypanosoma brucei gambiense strains from West and Central Africa isolated in the periods 1960-1995 and 1999-2004.
Topics: Africa, Central; Africa, Western; Animals; Humans; Inhibitory Concentration 50; Melarsoprol; Parasitic Sensitivity Tests; Time Factors; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo.
Topics: Adolescent; Adult; Animals; Child; Democratic Republic of the Congo; Disease Progression; Eflornithine; Female; Humans; Male; Melarsoprol; Retrospective Studies; Risk Assessment; Risk Factors; Secondary Prevention; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children.
Topics: Adolescent; Age Factors; Animals; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; Injections, Intramuscular; Melarsoprol; Pentamidine; Retrospective Studies; Sudan; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Human African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy.
Topics: Adult; Animals; Brain Diseases; Humans; Magnetic Resonance Imaging; Male; Melarsoprol; Polymerase Chain Reaction; Recurrence; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2007 |
Drug toxicity and cost as barriers to community participation in HAT control in the Democratic Republic of Congo.
Topics: Adult; Attitude to Health; Community Participation; Democratic Republic of the Congo; Female; Health Care Costs; Health Care Surveys; Health Knowledge, Attitudes, Practice; Health Services Accessibility; Humans; Male; Mass Screening; Melarsoprol; Patient Acceptance of Health Care; Personality Disorders; Rural Health; Trypanocidal Agents; Trypanosomiasis, African | 2007 |
Randomized, controlled trial of treatments for second-stage sleeping sickness.
Topics: Animals; Drug Therapy, Combination; Humans; Melarsoprol; Nifurtimox; Randomized Controlled Trials as Topic; Recurrence; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis.
Topics: Animals; Aprepitant; Disease Models, Animal; Drug Therapy, Combination; Humans; Melarsoprol; Mice; Morpholines; Neurokinin-1 Receptor Antagonists; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2007 |
Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients.
Topics: Animals; Diminazene; Drug Resistance, Multiple; Humans; Kenya; Melarsoprol; Mice; Parasitic Sensitivity Tests; Phenanthridines; Random Allocation; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda | 2007 |
Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go.
Topics: Drug Resistance; Drug Therapy, Combination; Eflornithine; Gambia; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African | 2007 |
Detection of mutant P2 adenosine transporter (TbAT1) gene in Trypanosoma brucei gambiense isolates from northwest Uganda using allele-specific polymerase chain reaction.
Topics: Alleles; Animals; Cattle; Drug Resistance; Melarsoprol; Nucleoside Transport Proteins; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda | 2007 |
Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola.
Topics: Angola; Animals; Cost of Illness; Cost-Benefit Analysis; Eflornithine; Humans; Melarsoprol; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2008 |
Trypanosoma brucei gambiense: cerebral immunopathology in mice.
Topics: Animals; Antibodies; Brain; Female; Fluorescent Antibody Technique; Melarsoprol; Meningoencephalitis; Mice; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1982 |
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei.
Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoenzymes; Male; Melarsoprol; Mice; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1984 |
Murine T lymphocyte specificity for African trypanosomes. II. Suppression of the T lymphocyte proliferative response to Trypanosoma brucei by systemic trypanosome infection.
Topics: Animals; Ascitic Fluid; Cell Division; Female; Immune Tolerance; Immunization; Macrophages; Male; Melarsoprol; Mice; T-Lymphocytes; T-Lymphocytes, Regulatory; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
[Treatment of human African trypanosomiasis].
Topics: Arsenicals; Humans; Melarsoprol; Rifamycins; Trypanosomiasis, African | 1983 |
The six diseases WHO. Human trypanosomiasis in Africa.
Topics: Economics, Medical; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African; Zambia | 1981 |
Chemotherapy, relapses and CNS in experimental African trypanosomiasis.
Topics: Animals; Central Nervous System; Chlorocebus aethiops; Chloroquine; Melarsoprol; Mice; Recurrence; Trypanosoma brucei brucei; Trypanosomiasis, African | 1983 |
Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study.
Topics: Animals; Antigen-Antibody Complex; Arsenicals; Brain; Brain Diseases; Chloroquine; Fluorescent Antibody Technique; Injections, Intraperitoneal; Injections, Intravenous; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
Immunopathological and chemotherapeutic studies in experimental trypanosomiasis with special reference to the heart and brain.
Topics: Animals; Brain; Disease Models, Animal; Ethidium; Female; Humans; Melarsoprol; Mice; Myocardium; Time Factors; Trypanosoma brucei brucei; Trypanosomiasis, African | 1980 |
Hepatic mixed-function oxidase activity in mice infected with Trypanosoma brucei gambiense or treated with trypanocides.
Topics: Animals; Arsenicals; Cytochrome P-450 Enzyme System; Liver; Male; Melarsoprol; Mice; Mixed Function Oxygenases; Oxidoreductases; Pentobarbital; Sleep; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
[Current therapy of trypanosomiasis].
Topics: Adenosylmethionine Decarboxylase; Animals; Arsenicals; Deoxyadenosines; Drug Resistance; Eflornithine; Enzyme Inhibitors; Hospitalization; Humans; Melarsoprol; Pentamidine; Randomized Controlled Trials as Topic; Recurrence; Suramin; Triazines; Trypanocidal Agents; Trypanosomiasis, African | 1994 |
[2 epidemics of arsenical encephalopathy in the treatment of trypanosomiasis, Uganda, 1992-1993].
Topics: Adolescent; Adult; Brain Diseases; Child; Disease Outbreaks; Drug Administration Schedule; Drug Interactions; Female; Health Status; Humans; Incidence; Male; Melarsoprol; Middle Aged; Retrospective Studies; Risk Factors; Seasons; Strongyloidiasis; Thiabendazole; Trypanocidal Agents; Trypanosomiasis, African; Uganda | 1994 |
[The distribution of sleep and wakefulness in human African trypanosomiasis].
Topics: Circadian Rhythm; Congo; Cote d'Ivoire; Electrocardiography; Electroencephalography; Humans; Melarsoprol; Meningoencephalitis; Niger; Polysomnography; Psychomotor Agitation; Pulmonary Ventilation; Respiratory Mechanics; Sleep; Time Factors; Trypanosomiasis, African; Wakefulness | 1994 |
[The sleep-wake cycle during Trypanosoma brucei rhodesiense human African trypanosomiasis in 2 French parachutists].
Topics: Adult; Animals; Arousal; Cerebellar Diseases; Circadian Rhythm; Electroencephalography; Epilepsies, Myoclonic; Follow-Up Studies; France; Humans; Male; Medulla Oblongata; Melarsoprol; Meningoencephalitis; Military Personnel; Polysomnography; Pyramidal Tracts; Rwanda; Sleep; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Wakefulness | 1994 |
In vivo evaluation of reuterin and its combinations with suramin, melarsoprol, DL-alpha-difluoromethylornithine and bleomycin in mice infected with Trypanosoma brucei brucei.
Topics: Aldehydes; Animals; Anti-Bacterial Agents; Bleomycin; Drug Therapy, Combination; Eflornithine; Female; Glyceraldehyde; Lethal Dose 50; Melarsoprol; Mice; Propane; Suramin; Trypanosomiasis, African | 1993 |
[Human African trypanosomiasis: disease of the future].
Topics: Brain; Electroencephalography; Humans; Melarsoprol; Primary Health Care; Social Change; Trypanosomiasis, African | 1994 |
Alternative application of melarsoprol for treatment of T. B. gambiense sleeping sickness. Preliminary results.
Topics: Adolescent; Adult; Animals; Drug Administration Schedule; Female; Humans; Male; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1995 |
[Control of Trypanosoma gambiense trypanosomiasis. Evaluation of a strategy based on the treatment of serologically suspected cases with a single dose of diminazene].
Topics: Agglutination Tests; Democratic Republic of the Congo; Diminazene; Humans; Incidence; Melarsoprol; Trypanosomiasis, African | 1994 |
Trypanosoma brucei rhodesiense: use of an antigen detection enzyme immunoassay for evaluation of response to chemotherapy in infected vervet monkeys (Cercopithecus aethiops).
Topics: Animals; Antigens, Protozoan; Chlorocebus aethiops; Enzyme-Linked Immunosorbent Assay; Female; Male; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1994 |
Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis.
Topics: Adolescent; Adrenal Cortex; Adult; Aged; Anemia; Animals; Hematocrit; Humans; Hydrocortisone; Hypogonadism; Luteinizing Hormone; Male; Melarsoprol; Middle Aged; Suramin; Testis; Testosterone; Time Factors; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1994 |
[Polyneuritis and myositis in Trypanosoma gambiense infection].
Topics: Animals; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Electromyography; Hepatomegaly; Humans; Male; Melarsoprol; Middle Aged; Myositis; Polyneuropathies; Prednisolone; Splenomegaly; Suramin; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1994 |
[Characteristics of trypanosomiasis in children. Apropos of 19 case reports at the CNPP (Neuro-Psycho-Pathology Center), University Hospitals of Kinshasa, Zaire].
Topics: Adolescent; Child; Child, Preschool; Democratic Republic of the Congo; Drug Therapy, Combination; Eflornithine; Follow-Up Studies; Humans; Melarsoprol; Trypanosomiasis, African | 1993 |
[A strategy to control Trypanosomiasis due to Trypanosoma brucei gambiense in an endemic region of Zaire. Association of a serological test and early treatment of suspected cases. Preliminary results].
Topics: Agglutination Tests; Animals; Clinical Protocols; Communicable Disease Control; Communicable Diseases; Decision Trees; Democratic Republic of the Congo; Humans; Incidence; Mass Screening; Melarsoprol; Pentamidine; Program Evaluation; Sensitivity and Specificity; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1993 |
Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO).
Topics: Animals; Drug Resistance; Eflornithine; Female; Humans; Hypoxanthine; Hypoxanthines; Melarsoprol; Mice; Mice, Inbred ICR; Nifurtimox; Species Specificity; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda | 1995 |
Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: the use of melarsoprol combined with the 5-nitroimidazole, megazol.
Topics: Administration, Topical; Animals; Brain Diseases; Dimethyl Sulfoxide; Drug Therapy, Combination; Female; Gels; Melarsoprol; Mice; Mice, Inbred Strains; Propylene Glycol; Propylene Glycols; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis, African | 1996 |
Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436.
Topics: Administration, Topical; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Combinations; Female; Gels; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1996 |
The importance of 2,3-dimercaptopropinol (British anti-lewisite, BAL) in the trypanocidal activity of topical melarsoprol.
Topics: Administration, Topical; Animals; Arsenicals; Dimercaprol; Drug Combinations; Female; Gels; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1996 |
Determination of melarsoprol in biological fluids by high-performance liquid chromatography and characterisation of two stereoisomers by nuclear magnetic resonance spectroscopy.
Topics: Animals; Body Fluids; Chromatography, High Pressure Liquid; Drug Stability; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Melarsoprol; Reproducibility of Results; Stereoisomerism; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1997 |
Endotoxin antibodies in African sleeping sickness.
Topics: Antibodies, Bacterial; Central Nervous System Diseases; Endotoxins; Gram-Negative Bacteria; Humans; Melarsoprol; Pentamidine; Trypanocidal Agents; Trypanosomiasis, African | 1997 |
Effect of melarsoprol treatment on circulating IL-10 and TNF-alpha levels in human African trypanosomiasis.
Topics: Adolescent; Adult; Female; Humans; Interleukin-10; Male; Melarsoprol; Trypanocidal Agents; Trypanosomiasis, African; Tumor Necrosis Factor-alpha | 1997 |
[Correspondence of the World Health Organization relative to the editorial by T. Ancelle (Med. Trop. 1996; 56: 347-348)].
Topics: Africa; Eflornithine; France; Global Health; Humans; International Cooperation; Melarsoprol; Pentamidine; Trypanocidal Agents; Trypanosomiasis, African; World Health Organization | 1997 |
In vivo evaluation of sixteen plant extracts on mice inoculated with Trypanosoma brucei gambiense.
Topics: Administration, Oral; Animals; Cote d'Ivoire; Eflornithine; Infusions, Parenteral; Injections, Intraperitoneal; Medicine, Traditional; Melarsoprol; Mice; Pentamidine; Plant Extracts; Sodium Chloride; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1997 |
Human African trypanosomiasis: MRI.
Topics: Adult; Animals; Brain; Drug Therapy, Combination; Encephalitis; Humans; Magnetic Resonance Imaging; Male; Melarsoprol; Meningitis; Prednisolone; Tomography, X-Ray Computed; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1997 |
[Current status of trypanosomiasis].
Topics: Africa; Animals; Autoantibodies; Blood-Brain Barrier; Brain Diseases; Follow-Up Studies; Forecasting; Humans; Incidence; Melarsoprol; Nitroimidazoles; Pentamidine; Population Surveillance; Protozoan Vaccines; Recurrence; Social Problems; Socioeconomic Factors; Survival Rate; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 1997 |
[In vivo resistance to strains of Trypanosoma rhodesiense, Mozambique, 1985].
Topics: Animals; Drug Resistance; Humans; Melarsoprol; Mice; Suramin; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1991 |
Discrepancy in plasma melarsoprol concentrations between HPLC and bioassay methods in patients with T. gambiense sleeping sickness indicates that melarsoprol is metabolized.
Topics: Adolescent; Adult; Animals; Biological Assay; Child; Chromatography, High Pressure Liquid; Female; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1998 |
Is sleeping sickness a circadian disorder? The serotonergic hypothesis.
Topics: Animals; Circadian Rhythm; Hormones; Humans; Melarsoprol; Melatonin; Meningoencephalitis; Models, Biological; Raphe Nuclei; Serotonin; Sleep; Sleep Stages; Sleep, REM; Suprachiasmatic Nucleus; Trypanocidal Agents; Trypanosomiasis, African | 1999 |
[Therapeutic failure of melarsoprol among patients treated for late stage T.b. gambiense human African trypanosomiasis in Uganda].
Topics: Drug Resistance; Humans; Melarsoprol; Treatment Failure; Trypanocidal Agents; Trypanosomiasis, African; Uganda | 1999 |
Reversal of the sleep/wake cycle disorder of sleeping sickness after trypanosomicide treatment.
Topics: Adult; Circadian Rhythm; Congo; Electrooculography; Female; Humans; Male; Melarsoprol; Middle Aged; Polysomnography; Severity of Illness Index; Sleep, REM; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African; Wakefulness | 1999 |
Production of sleeping-sickness treatment.
Topics: Cost-Benefit Analysis; Drug Compounding; Eflornithine; Humans; Melarsoprol; Sudan; Trypanocidal Agents; Trypanosomiasis, African; Uganda | 1999 |
Rhodesian trypanosomiasis in a splenectomized patient.
Topics: Adult; Africa; Animals; Central Nervous System Diseases; Humans; Male; Melarsoprol; Splenectomy; Suramin; Travel; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1999 |
Use of polymerase chain reaction in human African trypanosomiasis stage determination and follow-up.
Topics: Animals; Centrifugation; DNA, Protozoan; Follow-Up Studies; Humans; Melarsoprol; Polymerase Chain Reaction; Time Factors; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 1999 |
Towards developing a diagnostic regimen for the treatment follow-up of Trypanosoma brucei gambiense.
Topics: Animals; Follow-Up Studies; Melarsoprol; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1999 |
Anti-sleeping sickness drugs and cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2000 |
[Sleeping sickness in children at Bobo-Dioulasso Hospital Center: apropos of 3 cases].
Topics: Adolescent; Burkina Faso; Child, Preschool; Cote d'Ivoire; Eflornithine; Female; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosomiasis, African | 1999 |
[Melarsoprol].
Topics: Animals; Humans; Melarsoprol; Metabolic Clearance Rate; Patient Selection; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1999 |
Investigations of the metabolites of the trypanocidal drug melarsoprol.
Topics: Adult; Animals; Area Under Curve; Arsenic; Arsenicals; Biological Assay; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Female; Humans; Male; Melarsoprol; Mice; Mice, Inbred Strains; Microsomes, Liver; Spectrophotometry, Atomic; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2000 |
Suggested dosage rates of melarsoprol in the treatment of mice experimentally infected with Trypanosoma brucei gambiense.
Topics: Animals; Melarsoprol; Mice; Mice, Inbred BALB C; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2000 |
Treatment of human African trypanosomiasis.
Topics: Acetanilides; Africa; Humans; Melarsoprol; Nitroimidazoles; Pentamidine; Suramin; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis, African | 2000 |
Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.
Topics: Animals; DNA, Protozoan; Drug Resistance; Eflornithine; Humans; Melarsoprol; Microbial Sensitivity Tests; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda | 2001 |
Pharmacokinetic investigations in patients from northern Angola refractory to melarsoprol treatment.
Topics: Adolescent; Adult; Angola; Animals; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Female; Follow-Up Studies; Humans; Male; Melarsoprol; Middle Aged; Serotyping; Severity of Illness Index; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2001 |
Veterinary link to drug resistance in human African trypanosomiasis?
Topics: Animals; Cattle; Drug Resistance; Humans; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2001 |
Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy.
Topics: Adenosine; Animals; Carrier Proteins; Cerebrospinal Fluid; Drug Resistance; Genetic Variation; Humans; Melarsoprol; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Recurrence; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2001 |
[Human african trypanosomiasis: A history of its therapies and their failures].
Topics: Arsenicals; Drug Resistance; History, 20th Century; History, 21st Century; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2001 |
The phenomenon of treatment failures in Human African Trypanosomiasis.
Topics: Africa, Eastern; Animals; Dose-Response Relationship, Drug; Drug Resistance; Humans; Melarsoprol; Mice; Muridae; Parasitic Sensitivity Tests; Recurrence; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2001 |
Availability and affordability of treatment for Human African Trypanosomiasis.
Topics: Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Pentamidine; Research; Suramin; Trypanocidal Agents; Trypanosomiasis, African; World Health Organization | 2001 |
Drug companies and third world: a case study in neglect. Medicine merchants: a special report.
Topics: Delivery of Health Care; Developing Countries; Drug Industry; Fees, Pharmaceutical; Humans; Melarsoprol; Patents as Topic; Pharmaceutical Preparations; Research; Tropical Medicine; Trypanosomiasis, African; Uganda; World Health Organization | 2000 |
Sleeping sickness: new drugs from old? [corrected].
Topics: Africa South of the Sahara; Animals; Disease Models, Animal; Humans; Melarsoprol; Mice; Trypanocidal Agents; Trypanosomiasis, African | 2002 |
Human sleeping sickness in the Gboko endemic area of Nigeria.
Topics: Humans; Melarsoprol; Nigeria; Seasons; Trypanocidal Agents; Trypanosomiasis, African; Tsetse Flies | 1976 |
Mel B toxicity in human trypanosomiasis in the Gboko endemic area of Nigeria.
Topics: Adolescent; Adult; Arsenicals; Child; Diarrhea; Female; Fever; Humans; Male; Melarsoprol; Nigeria; Seizures; Trypanosomiasis, African | 1976 |
New leads for trypanosomiasis chemotherapy.
Topics: Chagas Disease; Drug Therapy, Combination; Heme; Humans; Melarsoprol; Naphthoquinones; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 1978 |
[Trypanosomiasis presenting with trypanids and complicated by myopericarditis (author's transl)].
Topics: Adult; Albumins; Blood Sedimentation; Erythema Multiforme; Heart Block; Humans; Lymphocytes; Male; Melarsoprol; Myocarditis; Pericarditis; Trypanosomiasis, African | 1979 |
Chemotherapy of sleeping sickness.
Topics: Arsenicals; Humans; Melarsoprol; Pentamidine; Suramin; Trypanosomiasis, African | 1979 |
Human trypanosomiasis in Southern Africa.
Topics: Complement System Proteins; Humans; Immunoglobulin M; Immunoglobulins; Male; Melarsoprol; Military Medicine; Pentamidine; South Africa; Trypanosomiasis, African | 1977 |
Complement activation in patients with Gambian sleeping sickness.
Topics: Complement C3; Complement C4; Complement System Proteins; Counterimmunoelectrophoresis; Cryoglobulins; Humans; Immunoglobulin M; Melarsoprol; Trypanosomiasis, African | 1976 |
Imported African trypanosomiasis in the United States.
Topics: Adult; Aged; Diagnosis, Differential; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Trypanosomiasis, African; United States | 1975 |
An evaluation of prednisolone as a routine adjunct to the treatment of T. rhodesiense.
Topics: Adult; Arsenicals; Child; Drug Administration Schedule; Drug Evaluation, Preclinical; Humans; Melarsoprol; Meningoencephalitis; Prednisolone; Suramin; Trypanosoma; Trypanosomiasis, African; Zambia | 1975 |
The treatment of T. rhodesiense sleeping sickness, with special reference to its physio-pathological and epidemiological basis.
Topics: Arsenicals; Chloroquine; Humans; Melarsoprol; Proguanil; Suramin; Trypanosomiasis, African; Zambia | 1975 |
Electrocardiographic changes in African trypanosomiasis caused by Trypanosoma brucei rhodesiense.
Topics: Adolescent; Adult; Aged; Electrocardiography; Female; Heart Diseases; Humans; Male; Melarsoprol; Middle Aged; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 1975 |
An in vitro bioassay for quantification of melarsoprol in serum and cerebrospinal fluid.
Topics: Animals; Biological Assay; Humans; Male; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1992 |
Arsenic, selenium, and African trypanosomiasis.
Topics: Brain Diseases; Humans; Melarsoprol; Selenium; Trypanosomiasis, African | 1992 |
Advances in sleeping sickness therapy.
Topics: Animals; Clinical Trials as Topic; Democratic Republic of the Congo; Eflornithine; Humans; Melarsoprol; Nifurtimox; Sudan; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1992 |
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.
Topics: Animals; Arsenicals; Calcium; Calcium Channels; Drug Resistance; Female; Melarsoprol; Mice; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
[Control of human African trypanosomiasis in Luba in equatorial Guinea:evaluation of three methods].
Topics: Animals; Diptera; Guinea; Insect Control; Insect Vectors; Mass Screening; Melarsoprol; Pentamidine; Prevalence; Program Evaluation; Seroepidemiologic Studies; Trypanosomiasis, African | 1991 |
[Electroencephalographic study of meningoencephalitis from Trypanosoma gambiense before and after treatment with melarsoprol].
Topics: Adolescent; Adult; Aged; Animals; Electroencephalography; Female; Humans; Male; Melarsoprol; Meningoencephalitis; Middle Aged; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1991 |
Screening compounds for sleeping sickness therapy without relapse.
Topics: Animals; Bleomycin; Drug Evaluation, Preclinical; Eflornithine; Melarsoprol; Metronidazole; Mice; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya.
Topics: Adult; Animals; Arsenicals; Drug Therapy, Combination; Eflornithine; Female; Humans; Kenya; Male; Melarsoprol; Middle Aged; Recurrence; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
Tryparsamide.
Topics: Drug Therapy, Combination; Humans; Melarsoprol; Nigeria; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1989 |
In vitro drug sensitivity of Trypanosoma gambiense isolates.
Topics: Animals; Arsenicals; Cote d'Ivoire; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1989 |
Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B.
Topics: Animals; Arsenicals; Brain; Central Nervous System; Central Nervous System Diseases; Goat Diseases; Goats; Male; Melarsoprol; Mice; Spinal Puncture; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1989 |
Treatment of Rhodesian sleeping sickness in Kenya.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arsenicals; Child; Drug Resistance; Female; Follow-Up Studies; Humans; Kenya; Male; Melarsoprol; Middle Aged; Prospective Studies; Recurrence; Retrospective Studies; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
Trypanosomiasis in a rural hospital in Tanzania. A retrospective study of its management and the results of treatment.
Topics: Animals; Arsenicals; Female; Follow-Up Studies; Humans; Male; Melarsoprol; Retrospective Studies; Rural Population; Tanzania; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
The potentiation of arsenicals with difluoromethylornithine (DFMO): experimental studies in murine trypanosomiasis.
Topics: Animals; Antimony Sodium Gluconate; Arsenicals; Drug Synergism; Drug Therapy, Combination; Eflornithine; Melarsoprol; Mice; Mitoguazone; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Adolescent; Animals; Arsenicals; Child; Child, Preschool; Diarrhea; Drug Resistance; Eflornithine; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Melarsoprol; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1987 |
[Action of drugs tested in an acellular medium and in mice infected with Trypanosoma brucei brucei].
Topics: Acetanilides; Animals; Culture Media; Cyclosporins; Eflornithine; In Vitro Techniques; Melarsoprol; Mice; Mitoguazone; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[Arsenical resistance and difluoromethylornithine in the treatment of human African trypanosomiasis].
Topics: Arsenicals; Drug Resistance; Eflornithine; Humans; Melarsoprol; Trypanosomiasis, African | 1988 |
Trypanosoma brucei rhodesiense: effect of immunosuppression on the efficacy of melarsoprol treatment of infected mice.
Topics: Animals; Arsenicals; Cyclophosphamide; Immunosuppression Therapy; Male; Melarsoprol; Mice; Mice, Inbred C3H; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[EEG and treatment with Arsobal in human African trypanosomiasis].
Topics: Animals; Arsenicals; Electroencephalography; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1988 |
[Complement: a sign of infestation of sheep by Trypanosoma brucei brucei in an experimental model: its evolution following treatment].
Topics: Animals; Arsenicals; Complement System Proteins; Disease Models, Animal; Melarsoprol; Sheep; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[Treatment of experimental trypanosomiasis caused by Trypanosoma brucei brucei in sheep: study of the minimum active dose of melarsoprol].
Topics: Animals; Arsenicals; Injections, Intravenous; Melarsoprol; Sheep; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[Arsenical-induced encephalopathy during the treatment of African trypanosomiasis. Apropos of a case with a favorable outcome].
Topics: Adult; Animals; Arsenicals; Brain Diseases; Humans; Male; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1988 |
The monitoring of trypanocidal treatment with a sensitive ELISA method for measuring melarsoprol levels in serum and in cerebrospinal fluids.
Topics: Arsenicals; Chemical Phenomena; Chemistry; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Melarsoprol; Spectrophotometry, Atomic; Trypanosomiasis, African | 1988 |
Progression of central nervous system lesions in the rat infected with Trypanosoma brucei gambiense. A light microscopic study.
Topics: Animals; Brain; Female; Melarsoprol; Rats; Rats, Inbred Strains; Time Factors; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1988 |
Melarsoprol toxicity in the treatment of human African trypanosomiasis. Ten cases treated with dimercaprol.
Topics: Adolescent; Adult; Arsenicals; Central Nervous System Diseases; Dimercaprol; Female; Humans; Male; Melarsoprol; Middle Aged; Trypanosomiasis, African | 1988 |
An unusual course of west African trypanosomiasis in a Caucasian man.
Topics: Adult; Arsenicals; Heart Block; Humans; Male; Melarsoprol; Polyradiculoneuropathy; Trypanosomiasis, African | 1987 |
Melarsoprol and reactive encephalopathy in Trypanosoma brucei rhodesiense.
Topics: Arsenicals; Brain Diseases; Humans; Melarsoprol; Trypanosoma brucei brucei; Trypanosomiasis, African | 1987 |
Trypanosoma brucei and T. vivax: salicylhydroxamic acid and glycerol treatment of acute and chronically infected rats.
Topics: Animals; Brain; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycerol; Melarsoprol; Mice; Muscles; Rats; Rats, Inbred Strains; Salicylamides; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis; Trypanosomiasis, African | 1986 |
Computer-assisted tomographic findings in a patient with African trypanosomiasis.
Topics: Brain Diseases; Child, Preschool; Diminazene; Humans; Male; Melarsoprol; Meningoencephalitis; Recurrence; Tomography, X-Ray Computed; Trypanosomiasis, African | 1986 |
Hyperendemic West African trypanosomiasis in a rural hospital setting.
Topics: Brain Diseases; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Hospitals, Rural; Humans; Melarsoprol; Nigeria; Suramin; Trypanosomiasis, African | 1985 |
African human trypanosomiasis in southern Sudan. Report of 77 cases.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Male; Melarsoprol; Middle Aged; Sudan; Suramin; Trypanosomiasis, African | 1985 |
Clinical and pathological aspects of human African trypanosomiasis (T. b. gambiense) with particular reference to reactive arsenical encephalopathy.
Topics: Animals; Arsenicals; Brain Diseases; Humans; Melarsoprol; Seizures; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1986 |