melarsoprol has been researched along with African Sleeping Sickness in 220 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (28.18) | 18.7374 |
| 1990's | 48 (21.82) | 18.2507 |
| 2000's | 64 (29.09) | 29.6817 |
| 2010's | 43 (19.55) | 24.3611 |
| 2020's | 3 (1.36) | 2.80 |
| Authors | Studies |
|---|---|
| Cerami, A; Ulrich, P | 1 |
| Brun, R; Chowdhury, SF; Croft, SL; Gilbert, IH; Goodman, JM; Guerrero, RH; Leal, I; Maes, L; Pacanowska, DG; Ruiz-Perez, LM; Villamor, VB | 1 |
| Baliani, A; Barrett, MP; Brun, R; Bueno, GJ; Gilbert, IH; Stewart, ML; Yardley, V | 1 |
| Brun, R; Dardonville, C; García, RN; Kaiser, M; Nguyen, B; Rodríguez, F; Rozas, I; Wilson, WD | 1 |
| Brun, R; Heidler, P; Kaiser, M; Link, A | 1 |
| Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA | 1 |
| Boykin, DW; Brun, R; Hall, JE; Ismail, MA; Tidwell, RR; Wenzler, T | 1 |
| Delfín, DA; Fotie, J; Kaiser, M; Li, C; Maes, L; Mahasenan, KV; Manley, J; Paris, JM; Reid, CS; Wenzler, T; Werbovetz, KA | 1 |
| Brun, R; Jędrysiak, R; Kaiser, M; Suwiński, J; Torreele, E; Trunz, BB; Tweats, D | 1 |
| Bayliss, T; Brand, S; Brenk, R; Cleghorn, LA; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Hallyburton, I; Harrison, JR; McElroy, SP; Norcross, NR; Norval, S; Read, KD; Robinson, DA; Smith, VC; Spinks, D; Stojanovski, L; Torrie, LS; Wyatt, PG | 1 |
| Braunschweig, H; Damme, A; Engstler, M; Hiltensperger, G; Holzgrabe, U; Jones, NG; Jung, J; Kaiser, M; Meinel, L; Niedermeier, S; Puhl, S; Stich, A | 1 |
| Brun, R; Connelly, MC; Guy, RK; Holbrook, G; Hwang, JY; Kaiser, M; Smithson, D; Zhu, F | 1 |
| Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C | 1 |
| Almohaywi, B; Avery, VM; Baell, JB; Campbell, M; Charman, SA; Ferrins, L; Hyland, C; Jones, AJ; Kaiser, M; Rahmani, R; Ryan, E; Smith, J; Sykes, ML; Teston, E; White, KL; Yin, J | 1 |
| Bakunov, SA; Bakunova, SM; Brun, R; Patrick, DA; Tidwell, RR; Wenzler, T | 1 |
| Cal, M; Dong, Y; Kaiser, M; Vennerstrom, JL; Wang, X | 1 |
| Dardonville, C; Kaiser, M; Lagartera, L; Ríos Martínez, CH | 1 |
| Brantner, A; Brun, R; Bucar, F; Faist, J; Gröblacher, B; Kaiser, M; Kalia, Y; Merino, V; Perozzo, R; Saf, R; Scapozza, L; Seebacher, W; Weis, R; Wolkinger, V | 1 |
| Brun, R; Göker, H; Kaiser, M; Karaaslan, C | 1 |
| Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR | 1 |
| Brun, R; Calvet, CM; Costi, R; De Leo, A; De Vita, D; Di Santo, R; Jennings, GK; Kaiser, M; Madia, VN; Mäser, P; Messore, A; Pescatori, L; Podust, LM; Saccoliti, F; Scipione, L; Tudino, V | 1 |
| Arroo, RRJ; Bhambra, AS; Botana, A; Ellinger, B; Eurtivong, C; Gul, S; Kaiser, M; Kuzikov, M; Lauga-Cami, S; Robinson, WJ; Schirmeister, T; Singh, K; Taylor, AE; Weaver, GW | 1 |
| Al-Salabi, MI; Alghamdi, AH; Anderson, LF; Boykin, DW; Campagnaro, GD; Carrington, M; Dardonville, C; De Koning, HP; Dimitriou, A; Eze, AA; Field, M; Gudin, S; Gurvic, D; Hulpia, F; Ibrahim, HM; Kelly, SPY; Kumar, A; Martin Abril, ME; Milić, P; Munday, JC; O'Neill, P; Okpara, CE; Paape, D; Quintana, J; Settimo, L; Smart, G; Sprenger, T; Svensson, F; Teka, IA; Tidwell, RR; Watson, L; Weyand, S; Wielinska, J; Woodley, CM; Zachariae, U | 1 |
| Auma, JE; Chemuliti, JK; Gitonga, PK; Kurgat, RK; Mdachi, RE; Murilla, GA; Ndung'u, K; Ngae, GN; Thuita, JK; Thungu, DK | 1 |
| Baker, N; Horn, D; Jeacock, L; Mäser, P; Wiedemar, N | 1 |
| Rushworth, SA; Steverding, D | 1 |
| Fairlamb, AH; Horn, D | 1 |
| Kaka, JT; Kazumba, LM; Ngoyi, DM; Tshala-Katumbay, D | 1 |
| Alsford, S; Baker, N; Dominicus, C; Glover, L; Horn, D; Hutchinson, S; Thomas, JA; Trenaman, A | 1 |
| Kennedy, A; Lutje, V; Seixas, J | 2 |
| Boykin, DW; Braissant, O; Brun, R; Wang, MZ; Wenzler, T; Yang, S | 1 |
| Brun, R; Büscher, P; de Koning, HP; Graf, FE; Horn, D; Kaiser, M; Ludin, P; Mäser, P; Pyana, PP; Wenzler, T | 1 |
| Boykin, DW; Braissant, O; Brun, R; Ismail, MA; Patrick, DA; Tidwell, RR; Wang, MZ; Wenzler, T; Yang, S | 1 |
| Büscher, P; Karhemere Bin Shamamba, S; Mumba Ngoyi, D; Ngay Lukusa, I; Pyana Pati, P; Van Reet, N | 1 |
| Bradley, B; Burrell-Saward, H; Croft, SL; Rodgers, J; Ward, TH | 1 |
| Baloji, S; Boelaert, M; da Luz, RI; Hendrickx, D; Lumbala, C; Lutumba, P; Mpanya, A | 1 |
| Arquint, C; Baker, N; Balmer, O; Caccone, A; de Koning, HP; Graf, FE; Horn, D; Krezdorn, J; Kunz Renggli, C; Ludin, P; Mäser, P; Munday, JC; Schaub, N; Schmidt, RS | 1 |
| Betu Ku Mesu Kande, V; Boelaert, M; Lutumba, P; Nyamowala, G; Robays, J; Sese, C; Van der Veken, W | 1 |
| Balasegaram, M; Chappuis, F; Checchi, F; Priotto, G; Raguenaud, ME; Young, H | 1 |
| Kaboya, JS; Kibona, SN; Manga, C; Mbilu, TJ; Nkya, GM; Rawille, F; Sindato, C | 1 |
| De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA | 1 |
| Blum, J; Brun, R; Burri, C; Chappuis, F | 1 |
| Schlitzer, M | 1 |
| Boelaert, M; Büscher, P; Lejon, V; Ngoyi, DM | 1 |
| Al-Salabi, MI; Augustyns, K; Berg, M; Castagna, V; Cos, P; de Koning, HP; Degano, M; Giannese, F; Grellier, P; Haemers, A; Joossens, J; Kohl, L; Maes, L; Steyaert, J; Van der Veken, P; Versées, W | 1 |
| Barrett, MP | 2 |
| Farah, IO; Hau, J; Kagira, JM; Kariuki, C; Maina, N; Mwangangi, DM; Ngotho, M; Thuita, JK | 1 |
| Bandzouzi, B; Bouteille, B; Buguet, A; Cespuglio, R; Mpandzou, G; Ngampo, S; Vincendeau, P | 1 |
| Büscher, P; Kaiser, M; Karhemere Bin Shamamba, S; Mumba Ngoyi, D; Ngay Lukusa, I; Pyana, PP; Van Reet, N | 1 |
| Barat, C; Pepin, J; Tremblay, MJ | 1 |
| Barrett, MP; Bradley, B; Gettinby, G; Gibaud, S; Jones, A; Kennedy, PG; McCabe, C; Rodgers, J | 1 |
| Alsford, S; Baker, N; Berriman, M; Eckert, S; Field, MC; Glover, L; Horn, D; Leung, KF; Sanchez-Flores, A; Turner, DJ | 1 |
| Diarra, A; Franco, J; Jannin, J; Postigo, JA; Simarro, PP | 1 |
| Kennedy, PG | 1 |
| Bailey, R; Brown, M; Easom, N; Watson, J; Wise, E | 1 |
| Allan, M; Blum, J; Burri, C; Edielu, A; Haary, EP; Kakembo, A; Kibona, S; Kuepfer, I; Schmid, C | 1 |
| Baker, N; de Koning, HP; Horn, D; Mäser, P | 1 |
| Burri, C; Büscher, P; Gastellu-Etchegorry, M; Jannin, J; Legros, D; Ollivier, G; Paquet, C | 1 |
| Bradley, B; Gettinby, G; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J | 1 |
| Kager, PA | 1 |
| Kager, PA; Mendonça Melo, M; Rasica, M; Richter, C; van Thiel, PP; Wismans, PJ | 1 |
| Boa, F; Dje, NN; Doua, F; Miezan, TW | 1 |
| Nok, AJ | 1 |
| Barrett, MP; Krishna, S; Stich, A | 1 |
| Docampo, R; Moreno, SN | 1 |
| NEUJEAN, G | 1 |
| APTED, FI | 1 |
| PINTO, AR | 1 |
| CARMO, RP; CASEIRO, A; DE BASTO, AX; SILVA, MA | 1 |
| BURKE, J | 1 |
| NIXON, LC; TAUBE, E | 1 |
| ADRIA ENSSENS, K | 1 |
| JANSSENS, PG; MICHIELS, A; VAN BOGAERT, L; VAN DE STEEN, R | 1 |
| ROBERTSON, DH | 2 |
| Büscher, P; Etchegorry, MG; Legros, D; Lejon, V; Mbulamberi, D; Savignoni, A | 1 |
| Abel, PM; Behrend, M; Fleischmann, H; Kiala, G; Krishna, S; Lôa, V; Musolf, J; Stich, A; Théophile, J | 1 |
| FRIEDHEIM, EA | 1 |
| Bisser, S; Buguet, A; Cespuglio, R; Chapotot, F; Josenando, T | 1 |
| Asumu, PN; Bilenge, CM; Burri, C; Chappuis, F; Doua, F; Josenando, T; Manthelot, CR; Nangouma, A; Richer, M; Schmid, C; Simarro, PP | 1 |
| Mpia, B; Pépin, J | 2 |
| Bovier, PA; Chappuis, F; Meussen, A; Stietenroth, K; Udayraj, N | 1 |
| Blum, J; Burri, C; Schmid, C | 1 |
| Alibu, VP; Brun, R; Clayton, C; Marti, G; Renggli, CK; Richter, C; Seebeck, T; Shahi, S; Voncken, F | 1 |
| Kaboya, JS; Kibona, SN; Lubega, GW; Matemba, L | 1 |
| Berbari, EF; Klein, CJ; Kumar, N; Orenstein, R; Uslan, DZ; Windebank, AJ | 1 |
| Kibiki, GS; Murphy, DK | 1 |
| Franco, JR; Jannin, J; Louis, FJ; Ndongo, P; Nguema, E; Simarro, PP | 1 |
| Berbari, EF; Jacobson, KM; Kumar, N; Orenstein, R; Uslan, DZ | 1 |
| Bailey, W; Corrah, T; Faye, JA; Fleming, L; Greenwood, B; Guy, M; Howie, S; Molyneux, D; Noyes, H; Pepin, J; Whittle, H | 1 |
| Brun, R; Fomena, A; Likeufack, AC; Truc, P | 1 |
| Balasegaram, M; Checchi, F; Ghorashian, S; Hamel, C; Harris, S; Karunakara, U | 1 |
| Bisser, S; Būscher, P; Lejon, V; Miaka Mia Bilenge, C; N'Siesi, FX; Preux, PM; Van Nieuwenhove, S | 1 |
| Chappuis, F; Eperon, G; Loutan, L; Schmid, C | 1 |
| Checkley, AM; Gibson, WC; Jäger, HR; Mabey, DC; Pepin, J; Taylor, MN | 1 |
| Boelaert, M; Kande Betu Ku Mesu, V; Lefèvre, P; Lubanza, S; Lutumba, P; Robays, J; Van der Stuyft, P | 1 |
| Abel, PM; Krishna, S; Woodrow, CJ | 1 |
| Bradley, B; Kennedy, PG; Rodgers, J | 1 |
| Kagira, JM; Maina, N | 1 |
| Chappuis, F | 1 |
| Enyaru, JC; Lubega, GW; Matovu, E; Nerima, B | 1 |
| Blum, JA; Burri, C; Hatz, C; Kazumba, L; Mangoni, P; Zellweger, MJ | 1 |
| Boelaert, M; Josenando, T; Raguenaud, ME; Robays, J | 1 |
| Bisser, S; Boelaert, M; Büscher, P; Lejon, V; Menten, J; Mumba Ngoyi, D; N'siesi, FX; Robays, J; Roger, I | 1 |
| Hochmann, A; Lambert, PH; Poltera, AA | 2 |
| Dukes, P | 1 |
| Gasbarre, LC; Hug, K; Louis, J | 1 |
| Breton, JC; Catanzano, G; Dumas, M; Nicolas, JA; Pestre-Alexandre, M | 1 |
| Foulkes, JR | 2 |
| Poltera, AA | 2 |
| Hall, JE; Seed, JR; Shertzer, HG | 1 |
| Boa Yapo, F; Doua, F | 1 |
| Ancelle, T; Barret, B; Flachet, L; Moren, A | 1 |
| Bert, J; Bogui, P; Buguet, A; Doua, F; Gati, R; Mouanga, G; Sarda, J; Stanghellini, A; Tabaraud, F; Tapie, P | 1 |
| Brosset, C; Buguet, A; Imbert, P; Montmayeur, A | 1 |
| Bronner, U; Doua, F; Ericsson, O; Gustafsson, LL; Miézan, T; Rais, M; Rombo, L | 1 |
| Roberts, JF; Yunmbam, MK | 1 |
| Dumas, M | 2 |
| Blum, J; Brun, R; Burri, C | 1 |
| Bruneel, H; Burke, J; Degroof, D; Molisho, D; Pépin, J; van den Eeckhout, A | 1 |
| Gichuki, CW; Nantulya, VM; Sayer, PD | 1 |
| Doua, F; Yapo, FB | 1 |
| Jennings, FW | 2 |
| Dadzie, S; Kimata, DM; Makawiti, DW; Tengekyon, KM; Waindi, EN | 1 |
| Burkardt, H; Damian, MS; Dorndorf, W; Leinweber, B; Schachenmayr, W; Singer, I | 1 |
| Milord, F; Pépin, J | 1 |
| Kazadi, K; Kazumba, M; Mulumba, MP | 1 |
| Bruneel, H; De Groof, D; Mungoma, K; Ruppol, JF | 1 |
| Brun, R; Iten, M; Kaminsky, R; Matovu, E | 1 |
| Chauvière, G; Jennings, FW; Murray, M; Viode, C | 1 |
| Atouguia, JM; Jennings, FW; Murray, M | 2 |
| Bronner, U; Ericsson, O; Fridén, M; Gustafsson, LL; Rombo, L; Schweda, EK | 1 |
| Alafiatayo, RA; Barclay, GR; Crawley, B; Doua, F; Oppenheim, BA; Pentreath, VW | 1 |
| Buguet, A; Dumas, M; Muanga, G; Radomski, MW; Rhind, SG; Sabiston, BH; Shek, PN; Stanghellini, A | 1 |
| Bales, JD; Harris, RW; Harrison, SM | 1 |
| Cattand, P; Jannin, J | 1 |
| Bamba, M; Coulibaly, S; Doua, F; Miezan, TB; Youan, BB | 1 |
| Bonardel, G; Briant, JF; Brosset, C; Imbert, P; Jeandel, P; Sabbah, P | 1 |
| Bouteille, B; Dumas, M | 2 |
| Lastre González, M; Pérez Martín, O; Shwalbach, J; Urban, M | 1 |
| Boa, YF; Bronner, U; Brun, R; Burri, C; Doua, F; Ericsson, O; Gustafsson, LL; Keiser, J; Miézan, TW; Rombo, L | 1 |
| Buguet, A | 1 |
| Fournier, C; Gastellu Etchegorry, M; Legros, D; Maiso, F; Szumilin, E | 1 |
| Bert, J; Buguet, A; Tapie, P | 1 |
| Gastellu, M; Pécoul, B | 1 |
| Boken, D; Malesker, MA; Murphy, PJ; Ruma, TA; Smith, PW; Vuchetich, PJ | 1 |
| Cuny, G; Frézil, JL; Jamonneau, V; Truc, P | 1 |
| Alston, WK; Grace, C; Maguire, JH; Sinha, A; Westenfeld, F | 1 |
| Hirumi, H; Hirumi, K; Inoue, N; Mbati, PA; Situakibanza, NH | 2 |
| Barrett, MP; Barrett, SV | 1 |
| Bonkoungou, P; Millogo, A; Nacro, B; Sanou, M; Tall, F; Traoré, H; Traoré, S | 1 |
| Blum, J; Brun, R; Burri, C; Merolle, A; Nkunku, S; Smith, T | 1 |
| Simon, F | 1 |
| Burri, C; Ericsson, O; Keiser, J | 1 |
| Blum, J; Burri, C; Nkunku, S | 1 |
| Enyaru, JC; Kaminsky, R; Legros, D; Matovu, E; Schmid, C; Seebeck, T | 1 |
| Burri, C; Keiser, J | 1 |
| Enyaru, JC; Gallati, S; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Schneider, V; Seebeck, T | 1 |
| Legros, D; Ollivier, G | 1 |
| Brun, R; Burri, C; Kunz, C; Schmid, C; Schumacher, R | 1 |
| Etchegorry, MG; Helenport, JP; Jannin, J; Legros, D; Pecoul, B | 1 |
| McNeil, DG | 1 |
| Blum, J; Burri, C | 1 |
| Jennings, F; Kennedy, PG; Murray, M; Rodgers, J | 1 |
| Aiyedun, BA; Amodu, AA | 2 |
| Williamson, J | 1 |
| Charmot, G; Dupont, B; Lapresle, C | 1 |
| Basson, W; Myburgh, DP; Page, ML | 1 |
| Greenwood, BM; Whittle, HC | 1 |
| Brodsky, RE; Gibson, JJ; Schultz, MG; Spencer, HC | 1 |
| Buyst, H | 1 |
| Buyst, H; Jones, IG; Lowenthal, MN | 1 |
| Brun, R; Burri, C | 1 |
| Golden, MH | 1 |
| Van Nieuwenhove, S | 1 |
| Bacchi, CJ; Garofalo, J; Goldberg, B; Nathan, HC; Yarlett, N | 1 |
| Mateo, MJ; Mir, M; Roche, J; Sima, FO; Simarro, PP | 1 |
| Camara, P; Hamon, JF | 1 |
| Ormerod, WE; Raseroka, BH | 1 |
| Bales, JD; Harrison, SM; Mbwabi, DL; Schecter, PJ | 1 |
| Ethier, L; Guern, C; Mansinsa, D; Milord, F; Mpia, B; Pepin, J | 1 |
| Thomson, KD | 1 |
| Baeriswyl, S; Brun, R; Kunz, C | 1 |
| Chumo, DA; Muriithi, RM; Mwangi, J; Reardon, MJ; Towett, S; Wellde, BT | 1 |
| Abinya, A; Chumo, DA; Dola, S; Mbwabi, D; Reardon, MJ; Siongok, TA; Smith, DH; Wanyama, L; Wellde, BT | 1 |
| Dolmans, WM; Ebeling, MC; Veeken, HJ | 1 |
| Guern, C; Milord, F; Pepin, J; Schechter, PJ | 1 |
| Bouteille, B; Darde, ML; Pestre-Alexandre, M | 1 |
| Kazyumba, GL; Nkanga, N; Ruppol, JF; Tshefu, AK | 1 |
| Breton, JC; Dumas, M; Giordano, C; Girard, PL; Pestre Alexandre, M | 1 |
| Gutteridge, WE | 1 |
| Frommel, TO | 1 |
| Akani, F; Boa, FY; Giordano, C; Kouassi, B; Piquemal, M; Sonan, T; Yapi, P | 1 |
| Bouteille, B; Darde, ML; Monteil, J; Pestre-Alexandre, M | 1 |
| Bouteille, B; Breton, JC; Catanzano, G; Darde, ML; Dumas, M; Munoz, M; Nicolas, JA; Pestre-Alexandre, M | 1 |
| Kernbaum, S; Pialoux, G; Vachon, F | 1 |
| Cattand, P; Doua, F; Hamers, R; Maes, L; Vanderveken, M | 1 |
| Brucher, JM; Chirimwami, B; Gigase, PL; Van Marck, EA; Wery, M | 1 |
| Scena, MR | 1 |
| Corachán, M; Estruch, R; Grau Junyent, JM; Rozman, M; Urbano-Marquez, A | 1 |
| Arroz, JO | 1 |
| van der Meer, C; Versluijs-Broers, JA | 1 |
| Champalimaud, JL; Medina, EA; Ventura, FA | 1 |
| Agbowu, J; Ajayi, N; Weir, AB | 1 |
| Wu, SH | 1 |
| Adams, H; Dago, A; Haller, L; Merouze, F | 1 |
19 review(s) available for melarsoprol and African Sleeping Sickness
| Article | Year |
|---|---|
Melarsoprol Resistance in African Trypanosomiasis.
Topics: Aquaglyceroporins; Drug Resistance; Humans; Melarsoprol; Mutation; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2018 |
Chemotherapy for second-stage human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2013 |
[Agents for the treatment of African sleeping sickness. Those developed in the last century].
Topics: Animals; Eflornithine; History, 20th Century; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 2009 |
Chemotherapy for second-stage Human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2010 |
Potential new drugs for human African trypanosomiasis: some progress at last.
Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis.
Topics: Animals; Drug Therapy, Combination; Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African | 2012 |
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.
Topics: Animals; Aquaglyceroporins; Drug Resistance; Humans; Melarsoprol; Pentamidine; Phylogeny; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
Treatment of human African trypanosomiasis--present situation and needs for research and development.
Topics: Africa South of the Sahara; Animals; Benzamidines; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Thiadiazoles; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2002 |
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.
Topics: Animals; Drug Resistance; HIV; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2003 |
Waking up to sleeping sickness.
Topics: Africa South of the Sahara; Animals; Communicable Diseases, Emerging; Disease Outbreaks; Humans; Insect Vectors; Melarsoprol; Orphan Drug Production; Pest Control, Biological; Trypanocidal Agents; Trypanosomiasis, African; Tsetse Flies | 2003 |
Current chemotherapy of human African trypanosomiasis.
Topics: Animals; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 2003 |
Human trypanosomiasis in the Ivory Coast: therapy and problems.
Topics: Animals; Cote d'Ivoire; Eflornithine; Humans; Melarsoprol; Pentamidine; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1993 |
Combination chemotherapy of CNS trypanosomiasis.
Topics: Arsenicals; Central Nervous System Diseases; Drug Therapy, Combination; Humans; Melarsoprol; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1993 |
The treatment of human African trypanosomiasis.
Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1994 |
African trypanosomiasis in two travelers from the United States.
Topics: Female; Humans; Male; Melarsoprol; Middle Aged; Travel; Trypanosomiasis, African | 1999 |
[Sleeping sickness, a reemerging sickness].
Topics: Africa; Animals; Communicable Diseases, Emerging; Disease Reservoirs; Humans; Mass Screening; Melarsoprol; Population Surveillance; Protozoan Vaccines; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis, African; Vaccination | 2000 |
Treatment of late stage sleeping sickness caused by T.b. gambiense: a new approach to the use of an old drug.
Topics: Animals; Clinical Trials as Topic; Drug Administration Schedule; Humans; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
Chemotherapy of African trypanosomiasis.
Topics: Adult; Amidines; Animals; Cattle; Drug Resistance; Drug Therapy, Combination; Humans; Melarsoprol; Phenanthridines; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African; Trypanosomiasis, Bovine | 1976 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1985 |
16 trial(s) available for melarsoprol and African Sleeping Sickness
| Article | Year |
|---|---|
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.
Topics: Agglutination Tests; Antibodies, Protozoan; Eflornithine; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2010 |
Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage Rhodesiense sleeping sickness.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Drug Administration Schedule; Endemic Diseases; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Tanzania; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda | 2012 |
Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine.
Topics: Adolescent; Adult; Animals; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Female; Humans; Immunoglobulin M; Latex Fixation Tests; Leukocyte Count; Male; Melarsoprol; Middle Aged; Pentamidine; Recurrence; Risk Factors; Treatment Failure; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2003 |
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Male; Melarsoprol; Middle Aged; Time Factors; Trypanocidal Agents; Trypanosomiasis, African | 2005 |
Clinical aspects of 2541 patients with second stage human African trypanosomiasis.
Topics: Adolescent; Adult; Animals; Central Nervous System Protozoal Infections; Child; Child, Preschool; Female; Headache; Humans; Incidence; Infant; Internationality; Lymphatic Diseases; Male; Melarsoprol; Prospective Studies; Pruritus; Surveys and Questionnaires; Trypanocidal Agents; Trypanosomiasis, African | 2006 |
Randomized controlled trial of three regimens of melarsoprol in the treatment of Trypanosoma brucei gambiense trypanosomiasis.
Topics: Adolescent; Adult; Animals; Drug Administration Schedule; Female; Humans; Leukocyte Count; Lymph Nodes; Male; Melarsoprol; Proportional Hazards Models; Recurrence; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Adult; Animals; Brain Diseases; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Melarsoprol; Nifurtimox; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis).
Topics: Adult; Animals; Eflornithine; Electrocardiography; Female; Heart Diseases; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Novel markers for treatment outcome in late-stage Trypanosoma brucei gambiense trypanosomiasis.
Topics: Animals; Antibodies, Protozoan; Biomarkers; Cerebrospinal Fluid; Humans; Immunoglobulin M; Interleukin-10; Leukocyte Count; Melarsoprol; Predictive Value of Tests; Proteins; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2008 |
Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness.
Topics: Adult; Aged; Animals; Biomarkers; Blood Pressure; Drug Therapy, Combination; Female; Follow-Up Studies; Half-Life; Humans; Infusions, Intravenous; Male; Melarsoprol; Metabolic Clearance Rate; Pentamidine; Tissue Distribution; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1995 |
Attempt to correlate urine arsenic excretion with clinical course during melarsoprol therapy of patients with Rhodesian trypanosomiasis.
Topics: Adolescent; Adult; Aged; Animals; Arsenic; Child; Child, Preschool; Creatinine; Drug Therapy, Combination; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1997 |
Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial.
Topics: Adult; Angola; Animals; Brain Diseases; Drug Administration Schedule; Female; Humans; Injections, Intramuscular; Length of Stay; Male; Melarsoprol; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2000 |
Clinical description of encephalopathic syndromes and risk factors for their occurrence and outcome during melarsoprol treatment of human African trypanosomiasis.
Topics: Adult; Angola; Central Nervous System Protozoal Infections; Drug Administration Schedule; Female; Humans; Male; Melarsoprol; Middle Aged; Predictive Value of Tests; Risk Factors; Syndrome; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2001 |
Treatment of late stage sleeping sickness caused by T.b. gambiense: a new approach to the use of an old drug.
Topics: Animals; Clinical Trials as Topic; Drug Administration Schedule; Humans; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness.
Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Arsenicals; Child; Child, Preschool; Clinical Trials as Topic; Coma; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leukocyte Count; Male; Melarsoprol; Middle Aged; Prednisolone; Prognosis; Prospective Studies; Random Allocation; Sex Factors; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1989 |
[Current status of the therapy of human African trypanosomiasis].
Topics: Animals; Arsenicals; Clinical Trials as Topic; Glycolysis; Humans; Lipid Metabolism; Melarsoprol; Proteins; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African; Vaccines | 1985 |
186 other study(ies) available for melarsoprol and African Sleeping Sickness
| Article | Year |
|---|---|
Potential antitrypanosomal agents. 1,N2-Disubstituted 2-amino-5-hydroxy-4-methylnaphtho[1,2-d]thiazolium salts and related compounds.
Topics: Animals; Chemical Phenomena; Chemistry; Female; Mice; Rats; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1982 |
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
Topics: Animals; Drug Design; Folic Acid Antagonists; Humans; In Vitro Techniques; Leishmania infantum; Leishmania major; Macrophages, Peritoneal; Mice; Models, Molecular; Tetrahydrofolate Dehydrogenase; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 1999 |
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
Topics: Animals; Cell Line; Female; Furaldehyde; Hydrazones; Leishmania donovani; Mice; Nitrofurans; Nucleoside Transport Proteins; Rats; Thiophenes; Triazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2005 |
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship; Transition Temperature; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2008 |
Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites.
Topics: Adenosine; Animals; Inhibitory Concentration 50; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
Topics: Animals; Antiprotozoal Agents; Benzene; Cell Survival; Leishmania donovani; Mice; Myoblasts; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
Topics: Animals; Benzamidines; Central Nervous System; Female; Furans; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |
Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.
Topics: Acetates; Animals; Cells, Cultured; Esters; Humans; Mice; Molecular Structure; Myoblasts; Quinolines; Rats; Reactive Oxygen Species; Structure-Activity Relationship; Survival Rate; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2010 |
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Mice; Molecular Structure; Mutagenicity Tests; Nitroimidazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanosomiasis, African | 2011 |
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
Topics: Acyltransferases; Administration, Oral; Aminopyridines; Animals; Cell Line; Cell Survival; Crystallography, X-Ray; Databases, Factual; Humans; Models, Molecular; Molecular Conformation; Parasitic Sensitivity Tests; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2012 |
Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei.
Topics: Acute Disease; Animals; Cell Line; DNA Topoisomerases, Type II; DNA, Kinetoplast; Mice; Microscopy, Fluorescence; Mitochondria; Models, Molecular; Morpholines; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2012 |
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Topics: Animals; Benzamides; Cell Line; Drug Evaluation, Preclinical; Humans; Structure-Activity Relationship; Trypanosomiasis, African | 2013 |
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; ErbB Receptors; Humans; Indicators and Reagents; Lapatinib; Morpholines; Neglected Diseases; Phosphotransferases; Quinazolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
Topics: Anilides; Animals; Humans; Mice; Myoblasts, Skeletal; Rats; Species Specificity; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Isoxazoles; Mice; Molecular Structure; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Trypanosomiasis, African | 2014 |
Activity of diimidazoline amides against African trypanosomiasis.
Topics: Amides; Animals; Disease Models, Animal; Humans; Imidazolines; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 2014 |
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.
Topics: Animals; Antiparasitic Agents; Benzamides; Binding Sites; Cell Line; Cell Survival; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Female; Guanidines; Mice; Mice, Inbred Strains; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Surface Plasmon Resonance; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Urea | 2014 |
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Azabicyclo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship; Tissue Distribution; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2015 |
Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Topics: Aniline Compounds; Animals; Antiprotozoal Agents; Benzimidazoles; Cell Line; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2016 |
Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.
Topics: Acetamides; Animals; Mice; Nitroreductases; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis, African | 2016 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis, Visceral; Malaria, Falciparum; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2018 |
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines.
Topics: Animals; Cell Line; Drug Discovery; Humans; Models, Molecular; Pyrimidines; Rats; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2021 |
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter
Topics: Animals; Aquaporin 2; Aquaporins; Drug Resistance; Melarsoprol; Mutation; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2020 |
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentamidine; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda; Virulence | 2020 |
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.
Topics: Animals; Aquaglyceroporins; Biological Transport; Disease Models, Animal; Drug Resistance; Gene Knockout Techniques; Glycerol; Melarsoprol; Mice; Mice, Inbred BALB C; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2017 |
Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Eflornithine; Glioblastoma; HL-60 Cells; Humans; Melarsoprol; Temozolomide; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo.
Topics: Adolescent; Adult; Democratic Republic of the Congo; Disease Management; Drug Therapy, Combination; Eflornithine; Female; Hospital Records; Humans; Male; Melarsoprol; Middle Aged; Multivariate Analysis; Nifurtimox; Recurrence; Retrospective Studies; Risk Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult | 2018 |
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
Topics: Cell Biology; Humans; Lysosomes; Melarsoprol; Mitochondria; Mitochondrial Proteins; Mitosis; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2018 |
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.
Topics: Amidines; Animals; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Humans; Injections, Intraperitoneal; Melarsoprol; Mice; Parasitic Sensitivity Tests; Pentamidine; Time Factors; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2013 |
Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.
Topics: Aquaporin 2; DNA, Protozoan; Drug Resistance; Humans; Melarsoprol; Molecular Sequence Data; Mutation; Pentamidine; Protozoan Proteins; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2013 |
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.
Topics: Amidines; Animals; Dose-Response Relationship, Drug; Female; Humans; Melarsoprol; Mice; Pentamidine; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2014 |
Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo.
Topics: Adult; Animals; Aquaglyceroporins; Base Sequence; Democratic Republic of the Congo; DNA, Protozoan; Drug Resistance; Female; Genotype; Humans; Melarsoprol; Mice; Molecular Sequence Data; Mutant Chimeric Proteins; Mutation; Pentamidine; Phenotype; Recurrence; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2014 |
A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.
Topics: Animals; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Luminescent Measurements; Melarsoprol; Mice; Parasite Load; Reproducibility of Results; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2015 |
From health advice to taboo: community perspectives on the treatment of sleeping sickness in the Democratic Republic of Congo, a qualitative study.
Topics: Animals; Democratic Republic of the Congo; Focus Groups; Humans; Male; Melarsoprol; Middle Aged; Qualitative Research; Taboo; Trypanocidal Agents; Trypanosomiasis, African | 2015 |
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.
Topics: Amino Acid Sequence; Aquaporins; Comparative Genomic Hybridization; DNA, Protozoan; Drug Resistance; Genome, Protozoan; Heterozygote; Humans; Male; Melarsoprol; Nucleoside Transport Proteins; Parasitic Sensitivity Tests; Pentamidine; Phenotype; Polymorphism, Single Nucleotide; Protozoan Proteins; RNA-Binding Proteins; Sequence Alignment; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2016 |
High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Democratic Republic of the Congo; Female; Humans; Infant; Male; Melarsoprol; Middle Aged; Recurrence; Treatment Failure; Trypanocidal Agents; Trypanosomiasis, African | 2008 |
Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angola; Animals; Child; Developing Countries; Eflornithine; Female; Humans; International Agencies; Male; Melarsoprol; Middle Aged; Statistics as Topic; Sudan; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda; Voluntary Health Agencies; Young Adult | 2009 |
Challenges in the diagnosis and management of sleeping sickness in Tanzania: a case report.
Topics: Adult; Animals; Diagnosis, Differential; Humans; Male; Melarsoprol; Tanzania; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2008 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Disease Models, Animal; Drug Interactions; Eflornithine; Indomethacin; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nifurtimox; Pentamidine; Perfusion; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 2009 |
Human African trypanosomiasis.
Topics: Africa; Animals; Biomedical Research; Communicable Disease Control; Eflornithine; Endemic Diseases; Humans; Incidence; Insect Bites and Stings; Insect Vectors; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies; Variant Surface Glycoproteins, Trypanosoma | 2010 |
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.
Topics: Adenosine; Animals; Antiprotozoal Agents; Carrier Proteins; Gene Knockdown Techniques; Melarsoprol; Mice; Models, Chemical; N-Glycosyl Hydrolases; Pentamidine; RNA, Small Interfering; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense.
Topics: Anemia, Macrocytic; Animals; Blood Platelets; Cerebrospinal Fluid; Chlorocebus aethiops; Diminazene; Disease Models, Animal; Female; Hematology; Leukocytes; Male; Melarsoprol; Thrombocytopenia; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2011 |
Polysomnography as a diagnosis and post-treatment follow-up tool in human African trypanosomiasis: a case study in an infant.
Topics: Arsenic Poisoning; Child, Preschool; Congo; Female; Humans; Melarsoprol; Polysomnography; Sleep Wake Disorders; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2011 |
Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice.
Topics: Adaptation, Biological; Animals; Antiprotozoal Agents; Blood; Cerebrospinal Fluid; Female; Humans; Male; Melarsoprol; Mice; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2011 |
HIV-1 replication in monocyte-derived dendritic cells is stimulated by melarsoprol, one of the main drugs against human African trypanosomiasis.
Topics: APOBEC-3G Deaminase; Cell Differentiation; Cytidine Deaminase; Dendritic Cells; Gene Expression Regulation, Viral; HEK293 Cells; HIV-1; HIV-2; Humans; Interferon-alpha; Melarsoprol; Monocytes; Trypanosomiasis, African; Up-Regulation; Virus Replication | 2011 |
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
Topics: Administration, Oral; Africa South of the Sahara; Animals; Antiprotozoal Agents; Blood-Brain Barrier; Brain; Cyclodextrins; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Male; Melarsoprol; Mice; Models, Molecular; Molecular Structure; Parasite Load; Parasitic Sensitivity Tests; Radiography; Treatment Outcome; Trypanosoma brucei brucei; Trypanosomiasis, African | 2011 |
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Topics: Aquaglyceroporins; Drug Resistance; Eflornithine; Endocytosis; Glycosylation; High-Throughput Screening Assays; Humans; Lysosomes; Melarsoprol; Nifurtimox; Pentamidine; RNA Interference; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2012 |
An alternative form of melarsoprol in sleeping sickness.
Topics: Administration, Oral; Animals; Clinical Trials as Topic; Humans; Infusion Pumps; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2012 |
Lesson of the month: a psychiatric diagnosis overturned by a blood film.
Topics: Antibodies, Protozoan; Cerebrospinal Fluid; Diagnosis, Differential; Female; Humans; Melarsoprol; Mental Disorders; Middle Aged; Parasitemia; Paresthesia; Spinal Puncture; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2012 |
Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen.
Topics: Animals; Anti-Infective Agents, Local; Drug Synergism; Drug Therapy, Combination; Female; Humans; Melarsoprol; Mice; Parasitemia; Suramin; Time Factors; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2002 |
[The return of sleeping sickness in an epidemic form: international action for drugs].
Topics: Africa, Central; Animals; Disease Outbreaks; Eflornithine; Humans; International Cooperation; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
[Three patients with African sleeping sickness following a visit to Tanzania].
Topics: Africa; Animals; Fatal Outcome; Female; Humans; Male; Melarsoprol; Middle Aged; Netherlands; Recurrence; Tanzania; Travel; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2002 |
[Human African trypanosomiasis in Ivory Coast: biological characteristics after treatment. 812 cases treated in the Daloa focus (Ivory Coast)].
Topics: Animals; Antibodies, Protozoan; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Cote d'Ivoire; Follow-Up Studies; Humans; Melarsoprol; Recurrence; Severity of Illness Index; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2002 |
[Use of arsobal in the treatment of sleeping sickness].
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1952 |
The treatment of advanced cases of Rhodesian sleeping sickness by Mel. B. and arsobal.
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1953 |
The therapeutic effect on a group of sleeping sickness patients of a single injection of 3854 R.P. (mel B Friedheim-arsobal Spécia).
Topics: Animals; Arsenicals; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1954 |
Arsobal in the treatment of Rhodesian sleeping-sickness.
Topics: Animals; Arsenicals; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1954 |
[Study of the therapeutic value of arsobal in trypanosomiasis caused by Trypanosoma gambiense].
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis; Trypanosomiasis, African | 1957 |
The treatment of advanced trypanosomiasis rhodesiense with mel B.
Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1958 |
[Note on the toxicity of MEL B in Trypanosoma rhodesiense sleeping sickness].
Topics: Animals; Black People; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African | 1960 |
[African trypanosomiasis, virus disease, Mel B and encephalitis].
Topics: Animals; Arsenic Poisoning; Coxsackievirus Infections; Encephalitis; Enterovirus; Humans; Infections; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African; Virus Diseases | 1960 |
The treatment of sleeping sickness (mainly due to Trypanosoma rhodesiense) with melarsoprol. I. Reactions observed during treatment.
Topics: Animals; Arsenicals; Dimercaprol; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African | 1963 |
The treatment of sleeping sickness (mainly due to Trypanosoma rhodesiense) with melarsoprol.
Topics: Animals; Arsenicals; Dimercaprol; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African | 1963 |
Retaking sleeping sickness control in Angola.
Topics: Adolescent; Adult; Age Distribution; Aged; Angola; Animals; Child; Child, Preschool; Disease Outbreaks; Eflornithine; Female; Humans; Infant; Insect Vectors; Male; Melarsoprol; Middle Aged; Pentamidine; Sex Distribution; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies | 2004 |
Mel B in the treatment of tryparsamide resistant T. gambiense sleeping sickness: observations on drug resistance in the trypanosomes of the French Cameroun.
Topics: Animals; Arsenic; Arsenicals; Drug Resistance; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African | 1951 |
Sleep structure: a new diagnostic tool for stage determination in sleeping sickness.
Topics: Adolescent; Adult; Animals; Child; Female; Humans; Male; Melarsoprol; Polysomnography; Sleep; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2005 |
Trypanosomiasis relapse after melarsoprol therapy, Democratic Republic of Congo, 1982-2001.
Topics: Adolescent; Adult; Animals; Democratic Republic of the Congo; Female; Humans; Male; Melarsoprol; Middle Aged; Secondary Prevention; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2005 |
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis.
Topics: Adolescent; Adult; Child; Eflornithine; Female; Humans; Male; Melarsoprol; Sudan; Trypanocidal Agents; Trypanosomiasis, African | 2005 |
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
Topics: Animals; Arsenicals; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Humans; Melarsoprol; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2006 |
Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.
Topics: Animals; Diminazene; Drug Resistance; Humans; Mass Screening; Melarsoprol; Phenanthridines; Recurrence; Suramin; Tanzania; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2006 |
Melarsoprol-associated multifocal inflammatory CNS illness in African trypanosomiasis.
Topics: Anti-Inflammatory Agents; Female; Humans; Inflammation; Melarsoprol; Methylprednisolone; Middle Aged; Paresthesia; Trypanocidal Agents; Trypanosomiasis, African | 2006 |
Transverse myelitis due to trypanosomiasis in a middle aged Tanzanian man.
Topics: Animals; Developing Countries; Drug Therapy, Combination; Follow-Up Studies; Humans; Male; Melarsoprol; Middle Aged; Myelitis, Transverse; Neurologic Examination; Radiculopathy; Spinal Cord Compression; Suramin; Tanzania; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2006 |
The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea.
Topics: Agglutination Tests; Animals; Disease Outbreaks; Disease Vectors; Endemic Diseases; Equatorial Guinea; Fluorescent Antibody Technique, Indirect; Humans; Melarsoprol; Pentamidine; Population Surveillance; Prevalence; Recurrence; Rural Health; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
A woman with fever and rash after African safari.
Topics: Africa; Exanthema; Female; Fever; Humans; Melarsoprol; Middle Aged; Pentamidine; Suramin; Travel; Trypanocidal Agents; Trypanosomiasis, African | 2006 |
A Gambian infant with fever and an unexpected blood film.
Topics: Animals; Edema; Female; Fever; Gambia; Humans; Infant; Melarsoprol; Parasitemia; Treatment Outcome; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis, African | 2006 |
Comparison of the in vitro drug sensitivity of Trypanosoma brucei gambiense strains from West and Central Africa isolated in the periods 1960-1995 and 1999-2004.
Topics: Africa, Central; Africa, Western; Animals; Humans; Inhibitory Concentration 50; Melarsoprol; Parasitic Sensitivity Tests; Time Factors; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo.
Topics: Adolescent; Adult; Animals; Child; Democratic Republic of the Congo; Disease Progression; Eflornithine; Female; Humans; Male; Melarsoprol; Retrospective Studies; Risk Assessment; Risk Factors; Secondary Prevention; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2006 |
Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children.
Topics: Adolescent; Age Factors; Animals; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; Injections, Intramuscular; Melarsoprol; Pentamidine; Retrospective Studies; Sudan; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Human African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy.
Topics: Adult; Animals; Brain Diseases; Humans; Magnetic Resonance Imaging; Male; Melarsoprol; Polymerase Chain Reaction; Recurrence; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2007 |
Drug toxicity and cost as barriers to community participation in HAT control in the Democratic Republic of Congo.
Topics: Adult; Attitude to Health; Community Participation; Democratic Republic of the Congo; Female; Health Care Costs; Health Care Surveys; Health Knowledge, Attitudes, Practice; Health Services Accessibility; Humans; Male; Mass Screening; Melarsoprol; Patient Acceptance of Health Care; Personality Disorders; Rural Health; Trypanocidal Agents; Trypanosomiasis, African | 2007 |
Randomized, controlled trial of treatments for second-stage sleeping sickness.
Topics: Animals; Drug Therapy, Combination; Humans; Melarsoprol; Nifurtimox; Randomized Controlled Trials as Topic; Recurrence; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis.
Topics: Animals; Aprepitant; Disease Models, Animal; Drug Therapy, Combination; Humans; Melarsoprol; Mice; Morpholines; Neurokinin-1 Receptor Antagonists; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2007 |
Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients.
Topics: Animals; Diminazene; Drug Resistance, Multiple; Humans; Kenya; Melarsoprol; Mice; Parasitic Sensitivity Tests; Phenanthridines; Random Allocation; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda | 2007 |
Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go.
Topics: Drug Resistance; Drug Therapy, Combination; Eflornithine; Gambia; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African | 2007 |
Detection of mutant P2 adenosine transporter (TbAT1) gene in Trypanosoma brucei gambiense isolates from northwest Uganda using allele-specific polymerase chain reaction.
Topics: Alleles; Animals; Cattle; Drug Resistance; Melarsoprol; Nucleoside Transport Proteins; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda | 2007 |
Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola.
Topics: Angola; Animals; Cost of Illness; Cost-Benefit Analysis; Eflornithine; Humans; Melarsoprol; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2008 |
Trypanosoma brucei gambiense: cerebral immunopathology in mice.
Topics: Animals; Antibodies; Brain; Female; Fluorescent Antibody Technique; Melarsoprol; Meningoencephalitis; Mice; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1982 |
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei.
Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoenzymes; Male; Melarsoprol; Mice; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1984 |
Murine T lymphocyte specificity for African trypanosomes. II. Suppression of the T lymphocyte proliferative response to Trypanosoma brucei by systemic trypanosome infection.
Topics: Animals; Ascitic Fluid; Cell Division; Female; Immune Tolerance; Immunization; Macrophages; Male; Melarsoprol; Mice; T-Lymphocytes; T-Lymphocytes, Regulatory; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
[Treatment of human African trypanosomiasis].
Topics: Arsenicals; Humans; Melarsoprol; Rifamycins; Trypanosomiasis, African | 1983 |
The six diseases WHO. Human trypanosomiasis in Africa.
Topics: Economics, Medical; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African; Zambia | 1981 |
Chemotherapy, relapses and CNS in experimental African trypanosomiasis.
Topics: Animals; Central Nervous System; Chlorocebus aethiops; Chloroquine; Melarsoprol; Mice; Recurrence; Trypanosoma brucei brucei; Trypanosomiasis, African | 1983 |
Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study.
Topics: Animals; Antigen-Antibody Complex; Arsenicals; Brain; Brain Diseases; Chloroquine; Fluorescent Antibody Technique; Injections, Intraperitoneal; Injections, Intravenous; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
Immunopathological and chemotherapeutic studies in experimental trypanosomiasis with special reference to the heart and brain.
Topics: Animals; Brain; Disease Models, Animal; Ethidium; Female; Humans; Melarsoprol; Mice; Myocardium; Time Factors; Trypanosoma brucei brucei; Trypanosomiasis, African | 1980 |
Hepatic mixed-function oxidase activity in mice infected with Trypanosoma brucei gambiense or treated with trypanocides.
Topics: Animals; Arsenicals; Cytochrome P-450 Enzyme System; Liver; Male; Melarsoprol; Mice; Mixed Function Oxygenases; Oxidoreductases; Pentobarbital; Sleep; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
[Current therapy of trypanosomiasis].
Topics: Adenosylmethionine Decarboxylase; Animals; Arsenicals; Deoxyadenosines; Drug Resistance; Eflornithine; Enzyme Inhibitors; Hospitalization; Humans; Melarsoprol; Pentamidine; Randomized Controlled Trials as Topic; Recurrence; Suramin; Triazines; Trypanocidal Agents; Trypanosomiasis, African | 1994 |
[2 epidemics of arsenical encephalopathy in the treatment of trypanosomiasis, Uganda, 1992-1993].
Topics: Adolescent; Adult; Brain Diseases; Child; Disease Outbreaks; Drug Administration Schedule; Drug Interactions; Female; Health Status; Humans; Incidence; Male; Melarsoprol; Middle Aged; Retrospective Studies; Risk Factors; Seasons; Strongyloidiasis; Thiabendazole; Trypanocidal Agents; Trypanosomiasis, African; Uganda | 1994 |
[The distribution of sleep and wakefulness in human African trypanosomiasis].
Topics: Circadian Rhythm; Congo; Cote d'Ivoire; Electrocardiography; Electroencephalography; Humans; Melarsoprol; Meningoencephalitis; Niger; Polysomnography; Psychomotor Agitation; Pulmonary Ventilation; Respiratory Mechanics; Sleep; Time Factors; Trypanosomiasis, African; Wakefulness | 1994 |
[The sleep-wake cycle during Trypanosoma brucei rhodesiense human African trypanosomiasis in 2 French parachutists].
Topics: Adult; Animals; Arousal; Cerebellar Diseases; Circadian Rhythm; Electroencephalography; Epilepsies, Myoclonic; Follow-Up Studies; France; Humans; Male; Medulla Oblongata; Melarsoprol; Meningoencephalitis; Military Personnel; Polysomnography; Pyramidal Tracts; Rwanda; Sleep; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Wakefulness | 1994 |
In vivo evaluation of reuterin and its combinations with suramin, melarsoprol, DL-alpha-difluoromethylornithine and bleomycin in mice infected with Trypanosoma brucei brucei.
Topics: Aldehydes; Animals; Anti-Bacterial Agents; Bleomycin; Drug Therapy, Combination; Eflornithine; Female; Glyceraldehyde; Lethal Dose 50; Melarsoprol; Mice; Propane; Suramin; Trypanosomiasis, African | 1993 |
[Human African trypanosomiasis: disease of the future].
Topics: Brain; Electroencephalography; Humans; Melarsoprol; Primary Health Care; Social Change; Trypanosomiasis, African | 1994 |
Alternative application of melarsoprol for treatment of T. B. gambiense sleeping sickness. Preliminary results.
Topics: Adolescent; Adult; Animals; Drug Administration Schedule; Female; Humans; Male; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1995 |
[Control of Trypanosoma gambiense trypanosomiasis. Evaluation of a strategy based on the treatment of serologically suspected cases with a single dose of diminazene].
Topics: Agglutination Tests; Democratic Republic of the Congo; Diminazene; Humans; Incidence; Melarsoprol; Trypanosomiasis, African | 1994 |
Trypanosoma brucei rhodesiense: use of an antigen detection enzyme immunoassay for evaluation of response to chemotherapy in infected vervet monkeys (Cercopithecus aethiops).
Topics: Animals; Antigens, Protozoan; Chlorocebus aethiops; Enzyme-Linked Immunosorbent Assay; Female; Male; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1994 |
Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis.
Topics: Adolescent; Adrenal Cortex; Adult; Aged; Anemia; Animals; Hematocrit; Humans; Hydrocortisone; Hypogonadism; Luteinizing Hormone; Male; Melarsoprol; Middle Aged; Suramin; Testis; Testosterone; Time Factors; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1994 |
[Polyneuritis and myositis in Trypanosoma gambiense infection].
Topics: Animals; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Electromyography; Hepatomegaly; Humans; Male; Melarsoprol; Middle Aged; Myositis; Polyneuropathies; Prednisolone; Splenomegaly; Suramin; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1994 |
[Characteristics of trypanosomiasis in children. Apropos of 19 case reports at the CNPP (Neuro-Psycho-Pathology Center), University Hospitals of Kinshasa, Zaire].
Topics: Adolescent; Child; Child, Preschool; Democratic Republic of the Congo; Drug Therapy, Combination; Eflornithine; Follow-Up Studies; Humans; Melarsoprol; Trypanosomiasis, African | 1993 |
[A strategy to control Trypanosomiasis due to Trypanosoma brucei gambiense in an endemic region of Zaire. Association of a serological test and early treatment of suspected cases. Preliminary results].
Topics: Agglutination Tests; Animals; Clinical Protocols; Communicable Disease Control; Communicable Diseases; Decision Trees; Democratic Republic of the Congo; Humans; Incidence; Mass Screening; Melarsoprol; Pentamidine; Program Evaluation; Sensitivity and Specificity; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1993 |
Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO).
Topics: Animals; Drug Resistance; Eflornithine; Female; Humans; Hypoxanthine; Hypoxanthines; Melarsoprol; Mice; Mice, Inbred ICR; Nifurtimox; Species Specificity; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda | 1995 |
Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: the use of melarsoprol combined with the 5-nitroimidazole, megazol.
Topics: Administration, Topical; Animals; Brain Diseases; Dimethyl Sulfoxide; Drug Therapy, Combination; Female; Gels; Melarsoprol; Mice; Mice, Inbred Strains; Propylene Glycol; Propylene Glycols; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis, African | 1996 |
Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436.
Topics: Administration, Topical; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Combinations; Female; Gels; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1996 |
The importance of 2,3-dimercaptopropinol (British anti-lewisite, BAL) in the trypanocidal activity of topical melarsoprol.
Topics: Administration, Topical; Animals; Arsenicals; Dimercaprol; Drug Combinations; Female; Gels; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1996 |
Determination of melarsoprol in biological fluids by high-performance liquid chromatography and characterisation of two stereoisomers by nuclear magnetic resonance spectroscopy.
Topics: Animals; Body Fluids; Chromatography, High Pressure Liquid; Drug Stability; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Melarsoprol; Reproducibility of Results; Stereoisomerism; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1997 |
Endotoxin antibodies in African sleeping sickness.
Topics: Antibodies, Bacterial; Central Nervous System Diseases; Endotoxins; Gram-Negative Bacteria; Humans; Melarsoprol; Pentamidine; Trypanocidal Agents; Trypanosomiasis, African | 1997 |
Effect of melarsoprol treatment on circulating IL-10 and TNF-alpha levels in human African trypanosomiasis.
Topics: Adolescent; Adult; Female; Humans; Interleukin-10; Male; Melarsoprol; Trypanocidal Agents; Trypanosomiasis, African; Tumor Necrosis Factor-alpha | 1997 |
[Correspondence of the World Health Organization relative to the editorial by T. Ancelle (Med. Trop. 1996; 56: 347-348)].
Topics: Africa; Eflornithine; France; Global Health; Humans; International Cooperation; Melarsoprol; Pentamidine; Trypanocidal Agents; Trypanosomiasis, African; World Health Organization | 1997 |
In vivo evaluation of sixteen plant extracts on mice inoculated with Trypanosoma brucei gambiense.
Topics: Administration, Oral; Animals; Cote d'Ivoire; Eflornithine; Infusions, Parenteral; Injections, Intraperitoneal; Medicine, Traditional; Melarsoprol; Mice; Pentamidine; Plant Extracts; Sodium Chloride; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1997 |
Human African trypanosomiasis: MRI.
Topics: Adult; Animals; Brain; Drug Therapy, Combination; Encephalitis; Humans; Magnetic Resonance Imaging; Male; Melarsoprol; Meningitis; Prednisolone; Tomography, X-Ray Computed; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1997 |
[Current status of trypanosomiasis].
Topics: Africa; Animals; Autoantibodies; Blood-Brain Barrier; Brain Diseases; Follow-Up Studies; Forecasting; Humans; Incidence; Melarsoprol; Nitroimidazoles; Pentamidine; Population Surveillance; Protozoan Vaccines; Recurrence; Social Problems; Socioeconomic Factors; Survival Rate; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 1997 |
[In vivo resistance to strains of Trypanosoma rhodesiense, Mozambique, 1985].
Topics: Animals; Drug Resistance; Humans; Melarsoprol; Mice; Suramin; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1991 |
Discrepancy in plasma melarsoprol concentrations between HPLC and bioassay methods in patients with T. gambiense sleeping sickness indicates that melarsoprol is metabolized.
Topics: Adolescent; Adult; Animals; Biological Assay; Child; Chromatography, High Pressure Liquid; Female; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1998 |
Is sleeping sickness a circadian disorder? The serotonergic hypothesis.
Topics: Animals; Circadian Rhythm; Hormones; Humans; Melarsoprol; Melatonin; Meningoencephalitis; Models, Biological; Raphe Nuclei; Serotonin; Sleep; Sleep Stages; Sleep, REM; Suprachiasmatic Nucleus; Trypanocidal Agents; Trypanosomiasis, African | 1999 |
[Therapeutic failure of melarsoprol among patients treated for late stage T.b. gambiense human African trypanosomiasis in Uganda].
Topics: Drug Resistance; Humans; Melarsoprol; Treatment Failure; Trypanocidal Agents; Trypanosomiasis, African; Uganda | 1999 |
Reversal of the sleep/wake cycle disorder of sleeping sickness after trypanosomicide treatment.
Topics: Adult; Circadian Rhythm; Congo; Electrooculography; Female; Humans; Male; Melarsoprol; Middle Aged; Polysomnography; Severity of Illness Index; Sleep, REM; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African; Wakefulness | 1999 |
Production of sleeping-sickness treatment.
Topics: Cost-Benefit Analysis; Drug Compounding; Eflornithine; Humans; Melarsoprol; Sudan; Trypanocidal Agents; Trypanosomiasis, African; Uganda | 1999 |
Rhodesian trypanosomiasis in a splenectomized patient.
Topics: Adult; Africa; Animals; Central Nervous System Diseases; Humans; Male; Melarsoprol; Splenectomy; Suramin; Travel; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1999 |
Use of polymerase chain reaction in human African trypanosomiasis stage determination and follow-up.
Topics: Animals; Centrifugation; DNA, Protozoan; Follow-Up Studies; Humans; Melarsoprol; Polymerase Chain Reaction; Time Factors; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 1999 |
Towards developing a diagnostic regimen for the treatment follow-up of Trypanosoma brucei gambiense.
Topics: Animals; Follow-Up Studies; Melarsoprol; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1999 |
Anti-sleeping sickness drugs and cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2000 |
[Sleeping sickness in children at Bobo-Dioulasso Hospital Center: apropos of 3 cases].
Topics: Adolescent; Burkina Faso; Child, Preschool; Cote d'Ivoire; Eflornithine; Female; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosomiasis, African | 1999 |
[Melarsoprol].
Topics: Animals; Humans; Melarsoprol; Metabolic Clearance Rate; Patient Selection; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1999 |
Investigations of the metabolites of the trypanocidal drug melarsoprol.
Topics: Adult; Animals; Area Under Curve; Arsenic; Arsenicals; Biological Assay; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Female; Humans; Male; Melarsoprol; Mice; Mice, Inbred Strains; Microsomes, Liver; Spectrophotometry, Atomic; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2000 |
Suggested dosage rates of melarsoprol in the treatment of mice experimentally infected with Trypanosoma brucei gambiense.
Topics: Animals; Melarsoprol; Mice; Mice, Inbred BALB C; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2000 |
Treatment of human African trypanosomiasis.
Topics: Acetanilides; Africa; Humans; Melarsoprol; Nitroimidazoles; Pentamidine; Suramin; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis, African | 2000 |
Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.
Topics: Animals; DNA, Protozoan; Drug Resistance; Eflornithine; Humans; Melarsoprol; Microbial Sensitivity Tests; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda | 2001 |
Pharmacokinetic investigations in patients from northern Angola refractory to melarsoprol treatment.
Topics: Adolescent; Adult; Angola; Animals; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Female; Follow-Up Studies; Humans; Male; Melarsoprol; Middle Aged; Serotyping; Severity of Illness Index; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2001 |
Veterinary link to drug resistance in human African trypanosomiasis?
Topics: Animals; Cattle; Drug Resistance; Humans; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2001 |
Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy.
Topics: Adenosine; Animals; Carrier Proteins; Cerebrospinal Fluid; Drug Resistance; Genetic Variation; Humans; Melarsoprol; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Recurrence; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2001 |
[Human african trypanosomiasis: A history of its therapies and their failures].
Topics: Arsenicals; Drug Resistance; History, 20th Century; History, 21st Century; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2001 |
The phenomenon of treatment failures in Human African Trypanosomiasis.
Topics: Africa, Eastern; Animals; Dose-Response Relationship, Drug; Drug Resistance; Humans; Melarsoprol; Mice; Muridae; Parasitic Sensitivity Tests; Recurrence; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2001 |
Availability and affordability of treatment for Human African Trypanosomiasis.
Topics: Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Pentamidine; Research; Suramin; Trypanocidal Agents; Trypanosomiasis, African; World Health Organization | 2001 |
Drug companies and third world: a case study in neglect. Medicine merchants: a special report.
Topics: Delivery of Health Care; Developing Countries; Drug Industry; Fees, Pharmaceutical; Humans; Melarsoprol; Patents as Topic; Pharmaceutical Preparations; Research; Tropical Medicine; Trypanosomiasis, African; Uganda; World Health Organization | 2000 |
Sleeping sickness: new drugs from old? [corrected].
Topics: Africa South of the Sahara; Animals; Disease Models, Animal; Humans; Melarsoprol; Mice; Trypanocidal Agents; Trypanosomiasis, African | 2002 |
Human sleeping sickness in the Gboko endemic area of Nigeria.
Topics: Humans; Melarsoprol; Nigeria; Seasons; Trypanocidal Agents; Trypanosomiasis, African; Tsetse Flies | 1976 |
Mel B toxicity in human trypanosomiasis in the Gboko endemic area of Nigeria.
Topics: Adolescent; Adult; Arsenicals; Child; Diarrhea; Female; Fever; Humans; Male; Melarsoprol; Nigeria; Seizures; Trypanosomiasis, African | 1976 |
New leads for trypanosomiasis chemotherapy.
Topics: Chagas Disease; Drug Therapy, Combination; Heme; Humans; Melarsoprol; Naphthoquinones; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 1978 |
[Trypanosomiasis presenting with trypanids and complicated by myopericarditis (author's transl)].
Topics: Adult; Albumins; Blood Sedimentation; Erythema Multiforme; Heart Block; Humans; Lymphocytes; Male; Melarsoprol; Myocarditis; Pericarditis; Trypanosomiasis, African | 1979 |
Chemotherapy of sleeping sickness.
Topics: Arsenicals; Humans; Melarsoprol; Pentamidine; Suramin; Trypanosomiasis, African | 1979 |
Human trypanosomiasis in Southern Africa.
Topics: Complement System Proteins; Humans; Immunoglobulin M; Immunoglobulins; Male; Melarsoprol; Military Medicine; Pentamidine; South Africa; Trypanosomiasis, African | 1977 |
Complement activation in patients with Gambian sleeping sickness.
Topics: Complement C3; Complement C4; Complement System Proteins; Counterimmunoelectrophoresis; Cryoglobulins; Humans; Immunoglobulin M; Melarsoprol; Trypanosomiasis, African | 1976 |
Imported African trypanosomiasis in the United States.
Topics: Adult; Aged; Diagnosis, Differential; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Trypanosomiasis, African; United States | 1975 |
An evaluation of prednisolone as a routine adjunct to the treatment of T. rhodesiense.
Topics: Adult; Arsenicals; Child; Drug Administration Schedule; Drug Evaluation, Preclinical; Humans; Melarsoprol; Meningoencephalitis; Prednisolone; Suramin; Trypanosoma; Trypanosomiasis, African; Zambia | 1975 |
The treatment of T. rhodesiense sleeping sickness, with special reference to its physio-pathological and epidemiological basis.
Topics: Arsenicals; Chloroquine; Humans; Melarsoprol; Proguanil; Suramin; Trypanosomiasis, African; Zambia | 1975 |
Electrocardiographic changes in African trypanosomiasis caused by Trypanosoma brucei rhodesiense.
Topics: Adolescent; Adult; Aged; Electrocardiography; Female; Heart Diseases; Humans; Male; Melarsoprol; Middle Aged; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 1975 |
An in vitro bioassay for quantification of melarsoprol in serum and cerebrospinal fluid.
Topics: Animals; Biological Assay; Humans; Male; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1992 |
Arsenic, selenium, and African trypanosomiasis.
Topics: Brain Diseases; Humans; Melarsoprol; Selenium; Trypanosomiasis, African | 1992 |
Advances in sleeping sickness therapy.
Topics: Animals; Clinical Trials as Topic; Democratic Republic of the Congo; Eflornithine; Humans; Melarsoprol; Nifurtimox; Sudan; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1992 |
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.
Topics: Animals; Arsenicals; Calcium; Calcium Channels; Drug Resistance; Female; Melarsoprol; Mice; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
[Control of human African trypanosomiasis in Luba in equatorial Guinea:evaluation of three methods].
Topics: Animals; Diptera; Guinea; Insect Control; Insect Vectors; Mass Screening; Melarsoprol; Pentamidine; Prevalence; Program Evaluation; Seroepidemiologic Studies; Trypanosomiasis, African | 1991 |
[Electroencephalographic study of meningoencephalitis from Trypanosoma gambiense before and after treatment with melarsoprol].
Topics: Adolescent; Adult; Aged; Animals; Electroencephalography; Female; Humans; Male; Melarsoprol; Meningoencephalitis; Middle Aged; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1991 |
Screening compounds for sleeping sickness therapy without relapse.
Topics: Animals; Bleomycin; Drug Evaluation, Preclinical; Eflornithine; Melarsoprol; Metronidazole; Mice; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya.
Topics: Adult; Animals; Arsenicals; Drug Therapy, Combination; Eflornithine; Female; Humans; Kenya; Male; Melarsoprol; Middle Aged; Recurrence; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
Tryparsamide.
Topics: Drug Therapy, Combination; Humans; Melarsoprol; Nigeria; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1989 |
In vitro drug sensitivity of Trypanosoma gambiense isolates.
Topics: Animals; Arsenicals; Cote d'Ivoire; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1989 |
Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B.
Topics: Animals; Arsenicals; Brain; Central Nervous System; Central Nervous System Diseases; Goat Diseases; Goats; Male; Melarsoprol; Mice; Spinal Puncture; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1989 |
Treatment of Rhodesian sleeping sickness in Kenya.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arsenicals; Child; Drug Resistance; Female; Follow-Up Studies; Humans; Kenya; Male; Melarsoprol; Middle Aged; Prospective Studies; Recurrence; Retrospective Studies; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
Trypanosomiasis in a rural hospital in Tanzania. A retrospective study of its management and the results of treatment.
Topics: Animals; Arsenicals; Female; Follow-Up Studies; Humans; Male; Melarsoprol; Retrospective Studies; Rural Population; Tanzania; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
The potentiation of arsenicals with difluoromethylornithine (DFMO): experimental studies in murine trypanosomiasis.
Topics: Animals; Antimony Sodium Gluconate; Arsenicals; Drug Synergism; Drug Therapy, Combination; Eflornithine; Melarsoprol; Mice; Mitoguazone; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Adolescent; Animals; Arsenicals; Child; Child, Preschool; Diarrhea; Drug Resistance; Eflornithine; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Melarsoprol; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1987 |
[Action of drugs tested in an acellular medium and in mice infected with Trypanosoma brucei brucei].
Topics: Acetanilides; Animals; Culture Media; Cyclosporins; Eflornithine; In Vitro Techniques; Melarsoprol; Mice; Mitoguazone; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[Arsenical resistance and difluoromethylornithine in the treatment of human African trypanosomiasis].
Topics: Arsenicals; Drug Resistance; Eflornithine; Humans; Melarsoprol; Trypanosomiasis, African | 1988 |
Trypanosoma brucei rhodesiense: effect of immunosuppression on the efficacy of melarsoprol treatment of infected mice.
Topics: Animals; Arsenicals; Cyclophosphamide; Immunosuppression Therapy; Male; Melarsoprol; Mice; Mice, Inbred C3H; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[EEG and treatment with Arsobal in human African trypanosomiasis].
Topics: Animals; Arsenicals; Electroencephalography; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1988 |
[Complement: a sign of infestation of sheep by Trypanosoma brucei brucei in an experimental model: its evolution following treatment].
Topics: Animals; Arsenicals; Complement System Proteins; Disease Models, Animal; Melarsoprol; Sheep; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[Treatment of experimental trypanosomiasis caused by Trypanosoma brucei brucei in sheep: study of the minimum active dose of melarsoprol].
Topics: Animals; Arsenicals; Injections, Intravenous; Melarsoprol; Sheep; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[Arsenical-induced encephalopathy during the treatment of African trypanosomiasis. Apropos of a case with a favorable outcome].
Topics: Adult; Animals; Arsenicals; Brain Diseases; Humans; Male; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1988 |
The monitoring of trypanocidal treatment with a sensitive ELISA method for measuring melarsoprol levels in serum and in cerebrospinal fluids.
Topics: Arsenicals; Chemical Phenomena; Chemistry; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Melarsoprol; Spectrophotometry, Atomic; Trypanosomiasis, African | 1988 |
Progression of central nervous system lesions in the rat infected with Trypanosoma brucei gambiense. A light microscopic study.
Topics: Animals; Brain; Female; Melarsoprol; Rats; Rats, Inbred Strains; Time Factors; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1988 |
Melarsoprol toxicity in the treatment of human African trypanosomiasis. Ten cases treated with dimercaprol.
Topics: Adolescent; Adult; Arsenicals; Central Nervous System Diseases; Dimercaprol; Female; Humans; Male; Melarsoprol; Middle Aged; Trypanosomiasis, African | 1988 |
An unusual course of west African trypanosomiasis in a Caucasian man.
Topics: Adult; Arsenicals; Heart Block; Humans; Male; Melarsoprol; Polyradiculoneuropathy; Trypanosomiasis, African | 1987 |
Melarsoprol and reactive encephalopathy in Trypanosoma brucei rhodesiense.
Topics: Arsenicals; Brain Diseases; Humans; Melarsoprol; Trypanosoma brucei brucei; Trypanosomiasis, African | 1987 |
Trypanosoma brucei and T. vivax: salicylhydroxamic acid and glycerol treatment of acute and chronically infected rats.
Topics: Animals; Brain; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycerol; Melarsoprol; Mice; Muscles; Rats; Rats, Inbred Strains; Salicylamides; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis; Trypanosomiasis, African | 1986 |
Computer-assisted tomographic findings in a patient with African trypanosomiasis.
Topics: Brain Diseases; Child, Preschool; Diminazene; Humans; Male; Melarsoprol; Meningoencephalitis; Recurrence; Tomography, X-Ray Computed; Trypanosomiasis, African | 1986 |
Hyperendemic West African trypanosomiasis in a rural hospital setting.
Topics: Brain Diseases; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Hospitals, Rural; Humans; Melarsoprol; Nigeria; Suramin; Trypanosomiasis, African | 1985 |
African human trypanosomiasis in southern Sudan. Report of 77 cases.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Male; Melarsoprol; Middle Aged; Sudan; Suramin; Trypanosomiasis, African | 1985 |
Clinical and pathological aspects of human African trypanosomiasis (T. b. gambiense) with particular reference to reactive arsenical encephalopathy.
Topics: Animals; Arsenicals; Brain Diseases; Humans; Melarsoprol; Seizures; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1986 |