Page last updated: 2024-08-26

melanotan-ii and Obesity

melanotan-ii has been researched along with Obesity in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (47.62)29.6817
2010's8 (38.10)24.3611
2020's3 (14.29)2.80

Authors

AuthorsStudies
Bednarek, MA; Chen, AS; Chen, HY; Fong, TM; Goulet, MT; Guan, X; Howard, AD; MacIntyre, ED; MacNeil, DJ; MacNeil, T; Marsh, DJ; Nargund, RP; Rosenblum, CI; Shen, CP; Strack, AM; Tota, M; Van der Ploeg, LH; Weinberg, DH1
Eliason, NL; Low, MJ; Martin, L; Sharpe, AL1
Chhabra, KH; Jones, GL; Kiran, S; Low, MJ; Shangguan, G; Thompson, Z; Yu, H1
Bouvier, M; Lanfray, D; René, P; Richard, D1
Carter, CS; Cote, I; Green, SM; Morgan, D; Scarpace, PJ; Toklu, HZ; Tümer, N1
Bak, S; Delhanty, P; Fani, L; van den Akker, EL; van Rossum, EF1
Arenkiel, BR; Kim, ER; Lowell, BB; Sun, H; Tong, Q; Wu, Z; Xu, Y; Zhu, Y1
Allard, C; Laque, A; Mauvais-Jarvis, F; Münzberg, H; Nohara, K1
Baracos, VE; Chee, MJ; Colmers, WF; Doslikova, B; Luchtman, DW; Marks, DL1
Adams, JM; Chhabra, KH; Fagel, B; Lam, DD; Low, MJ; Qi, N; Rubinstein, M1
Li, DP; Ye, ZY1
Adan, RA; Bergen, DJ; Brakkee, JH; Brans, MA; Cuppen, E; Garner, KM; Mul, JD; Toonen, PW; van Boxtel, R1
Aubert, ML; Raposinho, PD; White, RB1
Ebling, FJ; Hastings, MH; Horan, TL; Mercer, JG; Morgan, PJ; Schuhler, S1
Li, G; Scarpace, PJ; Wilsey, JT; Zhang, Y1
Boggiano, MM; Chandler, PC; Oswald, KD; Viana, JB; Wauford, PK1
Adage, T; Adan, RA; Buwalda, B; de Vries, K; Kas, MJ; Kuipers, F; Nyakas, C; Scheurink, AJ; Thiele, TE; van Dijk, G; Wilkinson, CW1
Friedman-Einat, M; Hen, G; Hruby, VJ; Shinder, D; Simchaev, V; Yosefi, S1
Arima, H; Banno, R; Goto, M; Hayashi, M; Nagasaki, H; Oiso, Y; Ozaki, N; Sato, I; Watanabe, M1
Ogawa, R; Reizes, O; Seeley, RJ; Shi, H; Strader, AD1
Cettour-Rose, P; Rohner-Jeanrenaud, F1

Reviews

2 review(s) available for melanotan-ii and Obesity

ArticleYear
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
    European journal of pharmacology, 2002, Apr-12, Volume: 440, Issue:2-3

    Topics: Animals; Anti-Obesity Agents; Body Weight; Gene Expression; Humans; Melanocyte-Stimulating Hormones; Obesity; Receptors, Corticotropin; Receptors, Melanocortin

2002
The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.
    International journal of obesity (2005), 2014, Volume: 38, Issue:2

    Topics: Acetamides; alpha-MSH; Animals; Anti-Obesity Agents; Appetite Regulation; Body Mass Index; Energy Intake; Energy Metabolism; Gene Frequency; Genotype; Humans; Obesity; Peptides, Cyclic; Phenotype; Pyrrolidines; Receptor, Melanocortin, Type 4; Receptors, Cell Surface; Spiro Compounds

2014

Other Studies

19 other study(ies) available for melanotan-ii and Obesity

ArticleYear
Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.
    Neuropeptides, 2022, Volume: 96

    Topics: alpha-MSH; Animals; Male; Melanocortins; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Obesity; Peptides, Cyclic; Pro-Opiomelanocortin; Receptor, Melanocortin, Type 4

2022
Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.
    Molecular metabolism, 2020, Volume: 35

    Topics: Adiponectin; Adipose Tissue; alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Caloric Restriction; Disease Models, Animal; Female; Melanocortins; Metabolism, Inborn Errors; Mice; Mice, Knockout; Neurons; Obesity; Peptides, Cyclic; Pro-Opiomelanocortin; Signal Transduction; Sympathetic Nervous System

2020
Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.
    JCI insight, 2021, 02-22, Volume: 6, Issue:4

    Topics: alpha-MSH; Animals; Blood Glucose; Body Weight; Carrier Proteins; Cell Membrane; Disease Models, Animal; Female; HEK293 Cells; Humans; Male; Mice; Mutation; Obesity; Peptides, Cyclic; Phenotype; Protein Conformation; Receptor, Melanocortin, Type 4

2021
Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2018, 10-01, Volume: 315, Issue:4

    Topics: Activity Cycles; Adiposity; alpha-MSH; Animals; Arterial Pressure; Diet, High-Fat; Disease Models, Animal; Energy Intake; Energy Metabolism; Fasting; Feeding Behavior; Hypertension; Male; Obesity; Peptides, Cyclic; Photoperiod; Rats, Inbred BN; Rats, Inbred F344; Time Factors

2018
Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.
    Cell metabolism, 2013, Dec-03, Volume: 18, Issue:6

    Topics: alpha-MSH; Animals; Basic Helix-Loop-Helix Transcription Factors; Body Weight; Energy Metabolism; Female; Glutamic Acid; Hyperphagia; Male; Mice; Mice, Knockout; Neurons; Obesity; Paraventricular Hypothalamic Nucleus; Peptides, Cyclic; Potassium Chloride; Receptor, Melanocortin, Type 4; Repressor Proteins; RNA, Messenger; Vesicular Glutamate Transport Protein 2

2013
Central mechanisms of adiposity in adult female mice with androgen excess.
    Obesity (Silver Spring, Md.), 2014, Volume: 22, Issue:6

    Topics: Adipose Tissue, Brown; Adiposity; alpha-MSH; Androgens; Animals; Arcuate Nucleus of Hypothalamus; Body Composition; Body Weight; Dihydrotestosterone; Energy Metabolism; Female; Hyperphagia; Hypothalamus; Intra-Abdominal Fat; Ion Channels; Leptin; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Peptides, Cyclic; Pro-Opiomelanocortin; Receptor, Melanocortin, Type 4; RNA, Messenger; Uncoupling Protein 1; Up-Regulation

2014
Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Caloric Restriction; Diet; Dietary Fats; gamma-Aminobutyric Acid; Leptin; Melanocortins; Neuropeptide Y; Obesity; Paraventricular Hypothalamic Nucleus; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 4; Ventromedial Hypothalamic Nucleus

2015
Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria.
    Diabetes, 2016, Volume: 65, Issue:3

    Topics: Agouti-Related Protein; alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Blotting, Western; Epinephrine; Glucose Tolerance Test; Glucose Transporter Type 2; Glycosuria, Renal; Hypothalamus; Injections, Intraventricular; Insulin Resistance; Kidney; Mice; Mice, Knockout; Norepinephrine; Obesity; Peptides, Cyclic; Pro-Opiomelanocortin; Receptors, Melanocortin; Sympathetic Nervous System

2016
Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats.
    Regulatory peptides, 2011, Jan-17, Volume: 166, Issue:1-3

    Topics: alpha-MSH; Animals; Bicuculline; Guanosine Diphosphate; Kynurenic Acid; Male; Melanocyte-Stimulating Hormones; Neurons; Obesity; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Peptides, Cyclic; Rats; Rats, Zucker; Receptor, Melanocortin, Type 4; Thionucleotides

2011
Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.
    Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:3

    Topics: alpha-MSH; Animals; Animals, Genetically Modified; Disease Models, Animal; Eating; Energy Metabolism; Food Preferences; Grooming; Obesity; Peptides, Cyclic; Rats; Receptor, Melanocortin, Type 4; Weight Gain

2012
The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat.
    Journal of neuroendocrinology, 2003, Volume: 15, Issue:2

    Topics: Adipocytes; Adipose Tissue; alpha-MSH; Animals; Carrier Proteins; Drinking; Drug Interactions; Eating; Gene Expression; Gonadal Steroid Hormones; Growth Hormone-Releasing Hormone; Hypothalamus; Insulin; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Leptin; Male; Neuropeptide Y; Neuropeptides; Obesity; Orexins; Peptides, Cyclic; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Weight Gain

2003
Feeding and behavioural effects of central administration of the melanocortin 3/4-R antagonist SHU9119 in obese and lean Siberian hamsters.
    Behavioural brain research, 2004, Jul-09, Volume: 152, Issue:2

    Topics: alpha-MSH; Analysis of Variance; Animals; Body Weight; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Eating; Feeding Behavior; Grooming; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones; Motor Activity; Obesity; Peptides, Cyclic; Photoperiod; Receptors, Corticotropin; Time Factors

2004
Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression.
    The Journal of endocrinology, 2004, Volume: 182, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adipose Tissue, Brown; alpha-MSH; Animals; Body Temperature Regulation; Carnitine O-Palmitoyltransferase; Cholesterol; Diet; Energy Intake; Female; Hypothalamus; Insulin; Models, Animal; Muscle, Skeletal; Obesity; Oxygen Consumption; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4

2004
Feeding response to melanocortin agonist predicts preference for and obesity from a high-fat diet.
    Physiology & behavior, 2005, Jun-02, Volume: 85, Issue:2

    Topics: alpha-MSH; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Dietary Fats; Eating; Feeding Behavior; Injections, Intraventricular; Male; Obesity; Oxygen Consumption; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Time Factors

2005
Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.
    Endocrinology, 2005, Volume: 146, Issue:12

    Topics: alpha-MSH; Animals; Anorexia; Diet; Eating; Humans; Injections, Intraventricular; Leptin; Male; Neurons; Neurosecretory Systems; Obesity; Paraventricular Hypothalamic Nucleus; Peptides, Cyclic; Predictive Value of Tests; Rats; Rats, Wistar; Receptors, Leptin; Receptors, Melanocortin

2005
The melanocortin circuit in obese and lean strains of chicks.
    The Journal of endocrinology, 2006, Volume: 190, Issue:2

    Topics: alpha-MSH; Animals; Chickens; Female; Gene Expression; Hypothalamus; Obesity; Peptides, Cyclic; Phenotype; Pro-Opiomelanocortin; Receptor, Melanocortin, Type 4; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity

2006
Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats.
    FEBS letters, 2007, Mar-20, Volume: 581, Issue:6

    Topics: Adipocytes; Adipose Tissue, White; alpha-MSH; Animals; Body Weight; Cytokines; Diet; Eating; Insulin; Insulin Resistance; Male; Melanocortins; Obesity; Peptides, Cyclic; Rats; Rats, Sprague-Dawley

2007
The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:3

    Topics: alpha-MSH; Animals; Body Weight; Intra-Abdominal Fat; Melanocortins; Mice; Mice, Obese; Obesity; Peptides, Cyclic; Subcutaneous Fat

2007
The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats.
    Endocrinology, 2002, Volume: 143, Issue:6

    Topics: Adipose Tissue; alpha-MSH; Animals; Blood Glucose; Blotting, Northern; Body Weight; Carnitine O-Palmitoyltransferase; Eating; Fatty Acids, Nonesterified; Injections, Intraperitoneal; Insulin; Leptin; Lipid Metabolism; Liver; Male; Melanocyte-Stimulating Hormones; Muscle, Skeletal; Obesity; Peptides, Cyclic; Rats; Rats, Zucker; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2002