meglutol has been researched along with Pregnancy in 10 studies
Meglutol: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
3-hydroxy-3-methylglutaric acid : A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aberrant fetal programming in gestational diabetes mellitus seems to increase the risk of obesity, type 2 diabetes, and cardiovascular disease." | 1.62 | Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming. ( Gornbein, JA; Koos, BJ, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koos, BJ | 1 |
| Gornbein, JA | 1 |
| Tabacik, C | 1 |
| Aliau, S | 1 |
| Astruc, M | 1 |
| De Paulet, AC | 1 |
| Roth, KS | 1 |
| Serabian, M | 1 |
| Medow, MS | 1 |
| Hammadeh, ME | 1 |
| Ertan, AK | 1 |
| Zeppezauer, M | 1 |
| Baltes, S | 1 |
| Georg, T | 1 |
| Rosenbaum, P | 1 |
| Schmidt, W | 1 |
| Duran, M | 1 |
| Schutgens, RB | 2 |
| Ketel, A | 1 |
| Heymans, H | 1 |
| Bertssen, MW | 1 |
| Ketting, D | 1 |
| Wadman, SK | 1 |
| Kuhara, T | 1 |
| Matsumoto, I | 1 |
| Saiki, K | 1 |
| Takabayashi, H | 1 |
| Kuwabara, S | 1 |
| Chitayat, D | 1 |
| Chemke, J | 1 |
| Gibson, KM | 1 |
| Mamer, OA | 1 |
| Kronick, JB | 1 |
| McGill, JJ | 1 |
| Rosenblatt, B | 1 |
| Sweetman, L | 1 |
| Scriver, CR | 1 |
| Wanders, RJ | 1 |
| Zoeters, BH | 1 |
| Chalmers, RA | 2 |
| Mistry, J | 2 |
| Penketh, R | 1 |
| McFadyen, IR | 2 |
| Tracey, BM | 1 |
| Stacey, TE | 1 |
10 other studies available for meglutol and Pregnancy
| Article | Year |
|---|---|
Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming.
Topics: Adult; Alanine; Arginine; Carnitine; Case-Control Studies; Diabetes, Gestational; Diet Therapy; Dopa | 2021 |
Squalene epoxidase, oxido-squalene cyclase and cholesterol biosynthesis in normal and tumoral mucosa of the human gastro-intestinal tract. Evidence of post-HHG CoA regulation.
Topics: Acetates; Acetic Acid; Adult; Aged; Animals; Cholesterol; Female; Gastric Mucosa; Gastrointestinal N | 1981 |
A comparison of the uptake of 3-hydroxy-3-methyl-glutaric acid in newborn and adult rat kidney.
Topics: Acetoacetates; Aminoisobutyric Acids; Animals; Animals, Newborn; Female; Glutarates; Keto Acids; Kid | 1982 |
Immunoglobulins and cytokines level in follicular fluid in relation to etiology of infertility and their relevance to IVF outcome.
Topics: Adult; Albumins; Cytokines; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Follicular | 2002 |
3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency: postnatal management following prenatal diagnosis by analysis of maternal urine.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Female; Humans; Hypoglycemia; Infant, Newborn | 1979 |
3-Methylglutaconic aciduria in two adults.
Topics: Adult; Female; Glutarates; Humans; Meglutol; Pregnancy | 1992 |
3-Methylglutaconic aciduria: a marker for as yet unspecified disorders and the relevance of prenatal diagnosis in a 'new' type ('type 4').
Topics: Amniotic Fluid; Child; Female; Fibroblasts; Glutarates; Humans; Hydro-Lyases; Male; Meglutol; Metabo | 1992 |
Prenatal diagnosis of 3-hydroxy-3-methylglutaric aciduria via enzyme activity measurements in chorionic villi, chorionic villous fibroblasts or amniocytes using a simple spectrophotometric method.
Topics: Amnion; Chorionic Villi; Female; Fibroblasts; Glutarates; Humans; Meglutol; Oxo-Acid-Lyases; Pregnan | 1988 |
First trimester prenatal diagnosis of 3-hydroxy-3-methylglutaric aciduria.
Topics: Chorionic Villi Sampling; Female; Glutarates; Humans; Meglutol; Metabolism, Inborn Errors; Oxo-Acid- | 1989 |
Prenatal diagnosis of 3-hydroxy-3-methylglutaric aciduria by GC-MS and enzymology on cultured amniocytes and chorionic villi.
Topics: Amino Acid Metabolism, Inborn Errors; Amnion; Cells, Cultured; Chorionic Villi; Consanguinity; Femal | 1989 |