meglutol has been researched along with Metabolic Acidosis in 10 studies
Meglutol: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
3-hydroxy-3-methylglutaric acid : A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we report the case of a 17-year-old girl who presented in both ten months and five years of age a clinical picture characterized by lethargy leading to apnea and coma, hepatomegaly, hypoglycemia, metabolic acidosis, hyperammoniemia, elevated serum transaminases and absence of ketonuria." | 3.70 | [3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome]. ( Castro-Gago, M; Eirís, J; Fernández-Prieto, R; Ribes, A; Rodríguez-García, J; Rodríguez-Segade, S, 1998) |
| "A 4-month-old infant with hypotonia and macrocephaly was diagnosed as having 3-hydroxy-3-methylglutaric aciduria, using gas chromatography and mass spectrometry and confirmatory enzyme studies." | 1.27 | Dizygotic twins with 3-hydroxy-3-methylglutaric aciduria; unusual presentation, family studies and dietary management. ( Chalmers, RA; de Sousa, C; Mistry, J; Stacey, TE; Timbrell, P; Tracey, BM; Whitelaw, A, 1985) |
| "A girl suffering from marked muscular hypotonia, severe statomotor and mental retardation, bilateral optic atrophy with chorioretinal degeneration, convulsions and a moderate compensated metabolic acidosis is described." | 1.27 | 3-Methylglutaconic and 3-methylglutaric aciduria in a patient with suspected 3-methylglutaconyl-CoA hydratase deficiency. ( Lehnert, W; Scharf, J; Wendel, U, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Santarelli, F | 1 |
| Cassanello, M | 1 |
| Enea, A | 1 |
| Poma, F | 1 |
| D'Onofrio, V | 1 |
| Guala, G | 1 |
| Garrone, G | 1 |
| Puccinelli, P | 1 |
| Caruso, U | 1 |
| Porta, F | 1 |
| Spada, M | 1 |
| Mulder, I | 1 |
| Van den Bergh, SG | 1 |
| Ozand, PT | 1 |
| Nyhan, WL | 1 |
| al Aqeel, A | 1 |
| Christodoulou, J | 1 |
| Fiumara, A | 1 |
| Barone, R | 1 |
| Nigro, F | 1 |
| Ribes, A | 2 |
| Pavone, L | 1 |
| Eirís, J | 1 |
| Fernández-Prieto, R | 1 |
| Rodríguez-García, J | 1 |
| Rodríguez-Segade, S | 1 |
| Castro-Gago, M | 1 |
| Shinka, T | 1 |
| Kuhara, T | 1 |
| Inoue, Y | 1 |
| Matsumoto, M | 1 |
| Matsumoto, I | 1 |
| Nakamura, H | 1 |
| Irimichi, H | 1 |
| Hasumi, K | 1 |
| Endo, A | 1 |
| Stacey, TE | 1 |
| de Sousa, C | 1 |
| Tracey, BM | 1 |
| Whitelaw, A | 1 |
| Mistry, J | 1 |
| Timbrell, P | 1 |
| Chalmers, RA | 1 |
| Dasouki, M | 1 |
| Buchanan, D | 1 |
| Mercer, N | 1 |
| Gibson, KM | 1 |
| Thoene, J | 1 |
| Haan, EA | 1 |
| Scholem, RD | 1 |
| Pitt, JJ | 1 |
| Wraith, JE | 1 |
| Brown, GK | 1 |
| Lehnert, W | 1 |
| Scharf, J | 1 |
| Wendel, U | 1 |
10 other studies available for meglutol and Metabolic Acidosis
| Article | Year |
|---|---|
A neonatal case of 3-hydroxy-3-methylglutaric-coenzyme A lyase deficiency.
Topics: Acetyl-CoA C-Acetyltransferase; Acidosis; Acute Disease; Amino Acid Metabolism, Inborn Errors; Gluta | 2013 |
Changes in rat-liver mitochondria during ketosis.
Topics: Acidosis; Acyl Coenzyme A; Adenosine Triphosphate; Animals; Calcium; Female; Freezing; Glutamate Deh | 1981 |
Malonic aciduria.
Topics: Acidosis; Carboxy-Lyases; Fibroblasts; Glutaryl-CoA Dehydrogenase; Humans; Infant; Infant, Newborn; | 1994 |
Pancreatitis and organic acidemias.
Topics: Acidosis; Acute Disease; Glutarates; Humans; Infant; Male; Meglutol; Pancreatitis | 1995 |
[3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome].
Topics: Acidosis; Adolescent; Apnea; Carnitine; Coma; Diagnosis, Differential; Fatty Liver; Female; Fibrobla | 1998 |
GC/MS analysis of urine in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.
Topics: Acidosis; Chromatography, Gas; Female; Humans; Hyperglycemia; Infant, Newborn; Leucine Zippers; Mass | 1992 |
Dizygotic twins with 3-hydroxy-3-methylglutaric aciduria; unusual presentation, family studies and dietary management.
Topics: Acidosis; Brain; Chromatography, Gas; Diet; Diseases in Twins; Female; Glutarates; Humans; Infant; M | 1985 |
3-Hydroxy-3-methylglutaric aciduria: response to carnitine therapy and fat and leucine restriction.
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Carnitine; Dietary Fats; Dietary Proteins; Female; G | 1987 |
Episodes of severe metabolic acidosis in a patient with 3-methylglutaconic aciduria.
Topics: Abnormalities, Multiple; Acidosis; Acidosis, Lactic; Child, Preschool; Citric Acid Cycle; Follow-Up | 1987 |
3-Methylglutaconic and 3-methylglutaric aciduria in a patient with suspected 3-methylglutaconyl-CoA hydratase deficiency.
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Female; Fibroblasts; Glutarates; Humans; Hydro-Lyase | 1985 |