meglutol has been researched along with Hypoglycemia in 4 studies
Meglutol: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
3-hydroxy-3-methylglutaric acid : A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we report the case of a 17-year-old girl who presented in both ten months and five years of age a clinical picture characterized by lethargy leading to apnea and coma, hepatomegaly, hypoglycemia, metabolic acidosis, hyperammoniemia, elevated serum transaminases and absence of ketonuria." | 3.70 | [3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome]. ( Castro-Gago, M; Eirís, J; Fernández-Prieto, R; Ribes, A; Rodríguez-García, J; Rodríguez-Segade, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Santarelli, F | 1 |
| Cassanello, M | 1 |
| Enea, A | 1 |
| Poma, F | 1 |
| D'Onofrio, V | 1 |
| Guala, G | 1 |
| Garrone, G | 1 |
| Puccinelli, P | 1 |
| Caruso, U | 1 |
| Porta, F | 1 |
| Spada, M | 1 |
| Pierron, S | 1 |
| Giudicelli, H | 1 |
| Moreigne, M | 1 |
| Khalfi, A | 1 |
| Touati, G | 1 |
| Caruba, C | 1 |
| Rolland, MO | 1 |
| Acquaviva, C | 1 |
| Eirís, J | 1 |
| Ribes, A | 1 |
| Fernández-Prieto, R | 1 |
| Rodríguez-García, J | 1 |
| Rodríguez-Segade, S | 1 |
| Castro-Gago, M | 1 |
| Duran, M | 1 |
| Schutgens, RB | 1 |
| Ketel, A | 1 |
| Heymans, H | 1 |
| Bertssen, MW | 1 |
| Ketting, D | 1 |
| Wadman, SK | 1 |
4 other studies available for meglutol and Hypoglycemia
| Article | Year |
|---|---|
A neonatal case of 3-hydroxy-3-methylglutaric-coenzyme A lyase deficiency.
Topics: Acetyl-CoA C-Acetyltransferase; Acidosis; Acute Disease; Amino Acid Metabolism, Inborn Errors; Gluta | 2013 |
[Late onset 3-HMG-CoA lyase deficiency: a rare but treatable disorder].
Topics: Alleles; Amino Acid Metabolism, Inborn Errors; Carnitine; Child, Preschool; Chromosome Aberrations; | 2010 |
[3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome].
Topics: Acidosis; Adolescent; Apnea; Carnitine; Coma; Diagnosis, Differential; Fatty Liver; Female; Fibrobla | 1998 |
3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency: postnatal management following prenatal diagnosis by analysis of maternal urine.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Female; Humans; Hypoglycemia; Infant, Newborn | 1979 |