meglutol has been researched along with Coma in 1 studies
Meglutol: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
3-hydroxy-3-methylglutaric acid : A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we report the case of a 17-year-old girl who presented in both ten months and five years of age a clinical picture characterized by lethargy leading to apnea and coma, hepatomegaly, hypoglycemia, metabolic acidosis, hyperammoniemia, elevated serum transaminases and absence of ketonuria." | 3.70 | [3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome]. ( Castro-Gago, M; Eirís, J; Fernández-Prieto, R; Ribes, A; Rodríguez-García, J; Rodríguez-Segade, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eirís, J | 1 |
| Ribes, A | 1 |
| Fernández-Prieto, R | 1 |
| Rodríguez-García, J | 1 |
| Rodríguez-Segade, S | 1 |
| Castro-Gago, M | 1 |
1 other study available for meglutol and Coma
| Article | Year |
|---|---|
[3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome].
Topics: Acidosis; Adolescent; Apnea; Carnitine; Coma; Diagnosis, Differential; Fatty Liver; Female; Fibrobla | 1998 |