mefruside has been researched along with Hypertension in 43 studies
Mefruside: A benzene-sulfonamide-furan. It is used as a diuretic that affects the concentrating ability of the KIDNEY, increases SODIUM CHLORIDE excretion, but may not spare POTASSIUM. It inhibits CARBONIC ANHYDRASES and may increase the blood URIC ACID level.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomised, parallel group study was designed to compare the efficacy of nifedipine (40 mg once daily) combined with either the dopamine agonist, co-dergocrine mesilate (4 mg once daily) or the diuretic mefruside (25 mg once daily) in 40 patients with essential arterial hypertension and a diastolic blood pressure greater than 105 mmHg." | 9.06 | Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension. ( Heintz, B; Heller, A; Kirsten, R; Nelson, K, 1990) |
| "35 patients with benign essential hypertension were treated for 6 weeks with high doses of the mineralocorticoid-antagonist spironolactone (400 mg/day), or with the "loop-diuretic" mefruside (mean maximal dose 110 mg/day)." | 9.04 | [Correlations between blood pressure, blood volume and plasma renin during therapy with diuretics in essential hypertension. Comparison between the mineralocorticoid antagonist spironolactone and the "loop" diuretic mefruside]. ( Beretta-Piccoli, C; de Châtel, R; Hirsch, D; Reubi, FC; Weidmann, P, 1977) |
| "The antihypertensive effects of the calcium antagonist diltiazem, both alone and combined with the diuretic mefruside, were assessed over 14 months in 36 patients with essential hypertension." | 7.67 | Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension. ( Distler, A; Gotzen, R; Meyer-Sabellek, W; Röcker, L; Schulte, KL, 1987) |
| "Fifty-two middle-aged patients with essential hypertension were treated for five months with 25 mg mefruside as the only antihypertensive drug." | 7.66 | Effects of mefruside treatment in hypertension. ( Bergengren, B; Henningsen, NC; Malmborg, O; Pihl, O; Renmarker, K; Strand, L, 1980) |
| "This randomised, parallel group study was designed to compare the efficacy of nifedipine (40 mg once daily) combined with either the dopamine agonist, co-dergocrine mesilate (4 mg once daily) or the diuretic mefruside (25 mg once daily) in 40 patients with essential arterial hypertension and a diastolic blood pressure greater than 105 mmHg." | 5.06 | Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension. ( Heintz, B; Heller, A; Kirsten, R; Nelson, K, 1990) |
| "A study was carried out in 16 patients with moderately severe hypertension to investigate the effects of nifedipine, given alone or combined with a diuretic, on blood pressure and on renal and platelet function." | 5.06 | Effect of nifedipine and mefruside on renal function and platelet function in hypertensive patients. ( Anderton, JL; Burnet, ME; Fiskerstrand, CE; Notghi, A, 1987) |
| " Therefore the ability of the beta-receptor antagonist acebutolol (400 mg/die) and of the diuretic mefrusid (25 mg/die) to reduce exercise-induced increases in blood pressure and pressure-rate product during and after standardized ergometric work (50--100 watts) was compared in a within-patient study of 42 outpatients with arterial hypertension (stage 1 to 2, WHO) aged 18 to 50 years." | 5.05 | [The effect of beta-receptor antagonists and diuretics and their combination on blood pressure and pressure-rate product during ergometric work in hypertensive patients (author's transl)]. ( Franz, IW, 1982) |
| "Systemic BP reduction, calf blood flow and vascular resistance in the calf were determined in forty-two previously untreated patients with mild to moderate essential hypertension (WHO I-WHO II) before and after 6 weeks, 6 months and 18 months of BP-lowering treatment with mefruside (25 mg daily) or atenolol (100--400 mg daily)." | 5.04 | Blood pressure reduction and vascular adaptation. A study on long-term effects of treatment with mefruside or atenolol. ( Andersson, O; Hansson, L; Sivertsson, R, 1979) |
| "35 patients with benign essential hypertension were treated for 6 weeks with high doses of the mineralocorticoid-antagonist spironolactone (400 mg/day), or with the "loop-diuretic" mefruside (mean maximal dose 110 mg/day)." | 5.04 | [Correlations between blood pressure, blood volume and plasma renin during therapy with diuretics in essential hypertension. Comparison between the mineralocorticoid antagonist spironolactone and the "loop" diuretic mefruside]. ( Beretta-Piccoli, C; de Châtel, R; Hirsch, D; Reubi, FC; Weidmann, P, 1977) |
| "Changes in glomerular filtration rate and effective renal plasma flow following a protein meal were measured in seven patients with essential hypertension on no treatment and after 6 weeks' treatment with nifedipine and mefruside." | 3.67 | Effect of nifedipine and mefruside on renal reserve in hypertensive patients. ( Anderton, JL; Notghi, A, 1988) |
| "The antihypertensive effects of the calcium antagonist diltiazem, both alone and combined with the diuretic mefruside, were assessed over 14 months in 36 patients with essential hypertension." | 3.67 | Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension. ( Distler, A; Gotzen, R; Meyer-Sabellek, W; Röcker, L; Schulte, KL, 1987) |
| "Fifty-two middle-aged patients with essential hypertension were treated for five months with 25 mg mefruside as the only antihypertensive drug." | 3.66 | Effects of mefruside treatment in hypertension. ( Bergengren, B; Henningsen, NC; Malmborg, O; Pihl, O; Renmarker, K; Strand, L, 1980) |
| "The long-term haemodynamic effects of treatment with mefruside alone or in combination with alprenolol have been studied in nine patients with essential hypertension." | 3.65 | Haemodynamic effects of saluretic treatment and beta-receptor blockade in patients with essential hypertension. ( Bevegård, S; Castenfors, J; Danielson, M, 1977) |
| "The haemodynamic changes after 4 months' mefruside therapy in 13 patients with essential hypertension have been studied." | 3.65 | Haemodynamic effects of four months' mefruside therapy in hypertensive patients. ( Bevegård, S; Castenfors, J; Danielson, M, 1977) |
| "Muscle content of water and electrolytes (needle biopsy), intraarterial BP and cardiac output (dye dilution technique) were measured in 12 patients with essential hypertension before and after 4 months of mefruside therapy (25 mg/day)." | 3.65 | Effect of saluretic therapy on muscle content of water and electrolytes in relation to hemodynamic variables. ( Bergström, J; Bevegård, S; Castenfors, J; Danielson, M, 1977) |
| "Mefruside (25 mg/d) was administered during the 4th and 5th weeks." | 2.68 | Antihypertensive mechanism of diuretics based on pressure-natriuresis relationship. ( Kimura, G; Saito, F, 1996) |
| " Nitrendipine (mean dose 32 mg/day) and acebutolol (414 mg/day) were administered in monotherapy in increasing dosage and mefruside was added in patients not controlled by monotherapy." | 2.66 | Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks. ( Amery, A; Ditu, M; Fagard, R; Lepira, B; Lijnen, P; Lissens, W; M'Buyamba-Kabangu, JR; Staessen, J; Tshiani, KA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (88.37) | 18.7374 |
| 1990's | 5 (11.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knüchel, F | 1 |
| Antognetti, R | 1 |
| Giovine, GG | 1 |
| Frisina, N | 1 |
| Macrì, I | 1 |
| Ussi, F | 1 |
| Pirrelli, A | 1 |
| Pieri, A | 1 |
| Misceo, N | 1 |
| Stella, M | 1 |
| Strippoli, M | 1 |
| Delle Gemme, E | 1 |
| Tomasi, AM | 1 |
| Pirani, R | 1 |
| Masoni, C | 1 |
| Douglas-Jones, AP | 1 |
| Mitchell, AD | 1 |
| Waeber, B | 1 |
| Avigdor, L | 1 |
| Brunner, HR | 1 |
| Alessandrini, A | 1 |
| Bianchi, RM | 1 |
| Legnani, W | 1 |
| Renzetti, I | 1 |
| Schulte, KL | 2 |
| Meyer-Sabellek, W | 2 |
| Gotzen, R | 2 |
| Franz, IW | 2 |
| Voigt, U | 1 |
| Brommer, W | 1 |
| Ciric, D | 1 |
| Felix, G | 1 |
| Otrzonsek, G | 1 |
| Windsheimer, F | 1 |
| Schneider, B | 1 |
| Seedat, YK | 1 |
| Werkö, L | 1 |
| Henningsen, NC | 1 |
| Bergengren, B | 1 |
| Malmborg, O | 1 |
| Pihl, O | 1 |
| Renmarker, K | 1 |
| Strand, L | 1 |
| Landmark, K | 1 |
| Forsman, M | 1 |
| Lindberg, K | 1 |
| Ryman, T | 1 |
| Martmann-Moe, K | 1 |
| Haaverstad, S | 1 |
| Wiel, S | 1 |
| Saito, F | 2 |
| Kimura, G | 2 |
| Jaillard, J | 1 |
| Sivertsson, R | 2 |
| Gudbrandsson, T | 1 |
| Hansson, L | 2 |
| Krämer, KD | 1 |
| Ghabussi, P | 1 |
| Hochrein, H | 1 |
| Schnicke, M | 1 |
| Olschowka, U | 1 |
| Rezori, R | 1 |
| Harvald, B | 1 |
| Fabricius, J | 1 |
| Thomsen, A | 1 |
| Andersson, O | 1 |
| Mérier, GR | 1 |
| Baczko, A | 1 |
| Bevegård, S | 4 |
| Castenfors, J | 4 |
| Danielson, M | 4 |
| Beretta-Piccoli, C | 1 |
| Weidmann, P | 1 |
| de Châtel, R | 1 |
| Hirsch, D | 1 |
| Reubi, FC | 1 |
| Jagenburg, R | 1 |
| Landahl, S | 1 |
| Steen, B | 1 |
| Bergström, J | 1 |
| Shintani, S | 1 |
| Shiigai, T | 1 |
| Tsukagoshi, H | 1 |
| Höfling, B | 1 |
| Häringer, E | 1 |
| Herrmann, W | 1 |
| Pieske, H | 1 |
| Pieske, R | 1 |
| Philippi, M | 1 |
| Kirsten, R | 1 |
| Heller, A | 1 |
| Heintz, B | 1 |
| Nelson, K | 1 |
| Poulter, N | 1 |
| Thompson, AV | 1 |
| Sever, PS | 1 |
| Notghi, A | 2 |
| Anderton, JL | 2 |
| Fiskerstrand, CE | 1 |
| Burnet, ME | 1 |
| Shimozaki, Y | 1 |
| Fujii, T | 1 |
| Ishii, T | 1 |
| Yoshida, K | 1 |
| Abe, H | 1 |
| Kawamura, M | 1 |
| Deguchi, F | 1 |
| Kawano, Y | 1 |
| Röcker, L | 1 |
| Distler, A | 1 |
| M'Buyamba-Kabangu, JR | 1 |
| Fagard, R | 1 |
| Lijnen, P | 1 |
| Staessen, J | 1 |
| Lissens, W | 1 |
| Ditu, M | 1 |
| Lepira, B | 1 |
| Tshiani, KA | 1 |
| Amery, A | 1 |
| Wardemann, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Once Versus Twice Daily Electrolyte Monitoring in CHF; a Study Monitoring Electrolytes in Congestive Heart Failure Patients Being Actively Diuresed in Hospital[NCT02497742] | 96 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 trials available for mefruside and Hypertension
| Article | Year |
|---|---|
[Clinical and statistical considerations on a new drug in the therapy of arterial hypertension. Controlled study].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Female; Guanabenz; Guan | 1984 |
[Treatment of arterial hypertension with a new drug combining guanabenz-mefruside].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Dose-Response Relationship, Drug; Drug Administrat | 1984 |
[Clinical use of various dosages of a centrally acting hypotensive drug associated with a diuretic].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Tolerance; Female; Guanabe | 1984 |
[Treatment of idiopathic hypertension with guanabenz-mefruside].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Dose-Response Relationship, Drug; Drug Combination | 1984 |
Comparison of nifedipine (retard formulation) and mefruside in the treatment of mild to moderate hypertension--a prospective randomized double-blind crossover study in general practice.
Topics: Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Humans; Hypertension; Male; Mefrus | 1984 |
[Evaluation of a drug combination for antihypertensive therapy in general practice].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Humans; | 1981 |
[The effect of beta-receptor antagonists and diuretics and their combination on blood pressure and pressure-rate product during ergometric work in hypertensive patients (author's transl)].
Topics: Acebutolol; Adolescent; Adult; Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Heart R | 1982 |
[Long-term antihypertensive therapy with Etozoline].
Topics: Adult; Drug Evaluation; Female; Humans; Hypertension; Inositol; Male; Mefruside; Middle Aged; Reserp | 1980 |
An evaluation of debrisoquine and mefruside in the treatment of hypertension in African and Indian patients.
Topics: Adult; Aged; Debrisoquin; Diuretics; Double-Blind Method; Drug Combinations; Drug Evaluation; Female | 1980 |
Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters.
Topics: Aged; Blood Pressure; Brain; Cardiac Output; Cerebrovascular Circulation; Double-Blind Method; Femal | 1995 |
Antihypertensive mechanism of diuretics based on pressure-natriuresis relationship.
Topics: Aged; Blood Pressure; Body Weight; Diuretics; Female; Humans; Hypertension; Male; Mefruside; Middle | 1996 |
Combination therapy with saluretics and atenolol in essential hypertension. Effects on blood pressure, electrolytes and uric acid.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Bendroflumethiazide; Chlorthalidone; Diuretics; | 1979 |
[Antihypertensive combination-therapy with inositol nicotinate in essential hypertension].
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Femal | 1977 |
[Mild and medium severe hypertension. Treatment of mild and medium severe hypertension with bendigon mite].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans | 1979 |
Haemodynamic parameters in hypertensive patients treated with a diuretic and with a diuretic in combination with a beta-blocker.
Topics: Adult; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Evaluation; Drug Therapy, Comb | 1979 |
Blood pressure reduction and vascular adaptation. A study on long-term effects of treatment with mefruside or atenolol.
Topics: Adult; Atenolol; Blood Pressure Determination; Diuretics; Female; Humans; Hypertension; Male; Mefrus | 1979 |
[Clinical assay of a debrisoquine-diuretic compound when treating moderate arterial hypertension (author's transl)].
Topics: Adult; Aged; Debrisoquin; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hypertensio | 1979 |
[Correlations between blood pressure, blood volume and plasma renin during therapy with diuretics in essential hypertension. Comparison between the mineralocorticoid antagonist spironolactone and the "loop" diuretic mefruside].
Topics: Blood Pressure; Blood Volume; Creatinine; Diuretics; Female; Humans; Hypertension; Male; Mefruside; | 1977 |
[Therapy of mild to moderate hypertension. Efficacy and tolerance of Amlodipine in comparison with the combination nifedipine/mefruside].
Topics: Adult; Aged; Amlodipine; Calcium Channel Blockers; Drug Combinations; Female; Humans; Hypertension; | 1991 |
Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Dihydroergotoxine; Drug Ther | 1990 |
A double-blind, placebo-controlled, crossover trial to investigate the additive hypotensive effect of a diuretic (mefruside) to that produced by nifedipine.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Synergis | 1987 |
Effect of nifedipine and mefruside on renal function and platelet function in hypertensive patients.
Topics: Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hy | 1987 |
Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks.
Topics: Acebutolol; Adolescent; Adult; Aged; Black or African American; Body Weight; Double-Blind Method; Dr | 1987 |
20 other studies available for mefruside and Hypertension
| Article | Year |
|---|---|
[Effect of beta-receptor blocking agents and diuretics and their combination on blood pressure during rest and exertion].
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Diuretics; Drug Combinations; Female; Humans; Hyp | 1982 |
Long-term follow-up study of hypertensive patients by practicing internists after a controlled drug trial.
Topics: Antihypertensive Agents; Blood Pressure; Debrisoquin; Double-Blind Method; Drug Therapy, Combination | 1984 |
[Effects of the short-term administration of a new preparation in the treatment of arterial hypertension].
Topics: Aged; Diuretics; Drug Evaluation; Drug Therapy, Combination; Female; Guanabenz; Guanidines; Humans; | 1984 |
Effects of acebutolol combined with mefruside on total-body and serum potassium in essential hypertensive patients.
Topics: Acebutolol; Adult; Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertensio | 1984 |
[Hypertension treatment: weight reduction training or drugs?].
Topics: Acebutolol; Adolescent; Adult; Blood Pressure; Diet, Reducing; Diuretics; Female; Humans; Hypertensi | 1983 |
[Hypertension treatment in a health resort].
Topics: Adult; Diuretics; Drug Combinations; Female; Health Resorts; Humans; Hypertension; Male; Mefruside; | 1981 |
Vascular adaptation to long-term blood pressure reduction.
Topics: Atenolol; Blood Pressure; Diuretics; Humans; Hypertension; Mefruside; Propanolamines; Vascular Resis | 1980 |
Effects of mefruside treatment in hypertension.
Topics: Aged; Blood Glucose; Cholesterol; Diuretics; Female; Humans; Hypertension; Male; Mefruside; Middle A | 1980 |
[Clinical experimentation with tensid (apropos of 60 cases)].
Topics: Adult; Aged; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hypertension; Inositol; | 1976 |
Peripheral haemodynamics in essential hypertension.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Blood Pressure; Cardiac Output; Hemodynamics; Huma | 1977 |
Carotid baroreceptor function in hypertensive patients.
Topics: Adult; Alprenolol; Blood Pressure; Cardiac Output; Carotid Sinus; Female; Heart Rate; Humans; Hypert | 1977 |
Haemodynamic effects of saluretic treatment and beta-receptor blockade in patients with essential hypertension.
Topics: Adult; Alprenolol; Blood Pressure; Cardiac Output; Diuretics; Drug Therapy, Combination; Female; Fol | 1977 |
Haemodynamic effects of four months' mefruside therapy in hypertensive patients.
Topics: Adult; Blood Pressure; Cardiac Output; Diuretics; Female; Follow-Up Studies; Heart Rate; Hemodynamic | 1977 |
[Blood pressure and serum potassium during 6 months of mefruside treatment].
Topics: Diuretics; Drug Evaluation; Female; Humans; Hypertension; Hypokalemia; Male; Mefruside; Potassium; T | 1977 |
Effect of saluretic therapy on muscle content of water and electrolytes in relation to hemodynamic variables.
Topics: Adult; Blood Pressure; Body Water; Cardiac Output; Diuretics; Female; Hemodynamics; Humans; Hyperten | 1977 |
Marked hypokalemic rhabdomyolysis with myoglobinuria due to diuretic treatment.
Topics: Aged; Biopsy; Electrocardiography; Furosemide; Humans; Hypertension; Hypokalemia; Male; Mefruside; M | 1991 |
Effect of nifedipine and mefruside on renal reserve in hypertensive patients.
Topics: Adult; Dietary Proteins; Diuretics; Glomerular Filtration Rate; Humans; Hypertension; Mefruside; Mid | 1988 |
[Mechanism of hypotensive action of a diuretic, mefruside, based on the pressure-natriuresis relationship].
Topics: Aged; Blood Pressure; Diet, Sodium-Restricted; Diuretics; Female; Humans; Hypertension; Kidney; Male | 1987 |
Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension.
Topics: Adult; Blood Pressure; Carbohydrate Metabolism; Diltiazem; Diuretics; Drug Therapy, Combination; Fem | 1987 |
[Clinical studies with a new antihypertensive agent, Bendigon].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Combinations; Drug Synergism; | 1970 |