mefruside has been researched along with Blood Pressure, High in 43 studies
Mefruside: A benzene-sulfonamide-furan. It is used as a diuretic that affects the concentrating ability of the KIDNEY, increases SODIUM CHLORIDE excretion, but may not spare POTASSIUM. It inhibits CARBONIC ANHYDRASES and may increase the blood URIC ACID level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomised, parallel group study was designed to compare the efficacy of nifedipine (40 mg once daily) combined with either the dopamine agonist, co-dergocrine mesilate (4 mg once daily) or the diuretic mefruside (25 mg once daily) in 40 patients with essential arterial hypertension and a diastolic blood pressure greater than 105 mmHg." | 9.06 | Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension. ( Heintz, B; Heller, A; Kirsten, R; Nelson, K, 1990) |
| "35 patients with benign essential hypertension were treated for 6 weeks with high doses of the mineralocorticoid-antagonist spironolactone (400 mg/day), or with the "loop-diuretic" mefruside (mean maximal dose 110 mg/day)." | 9.04 | [Correlations between blood pressure, blood volume and plasma renin during therapy with diuretics in essential hypertension. Comparison between the mineralocorticoid antagonist spironolactone and the "loop" diuretic mefruside]. ( Beretta-Piccoli, C; de Châtel, R; Hirsch, D; Reubi, FC; Weidmann, P, 1977) |
| "The antihypertensive effects of the calcium antagonist diltiazem, both alone and combined with the diuretic mefruside, were assessed over 14 months in 36 patients with essential hypertension." | 7.67 | Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension. ( Distler, A; Gotzen, R; Meyer-Sabellek, W; Röcker, L; Schulte, KL, 1987) |
| "Fifty-two middle-aged patients with essential hypertension were treated for five months with 25 mg mefruside as the only antihypertensive drug." | 7.66 | Effects of mefruside treatment in hypertension. ( Bergengren, B; Henningsen, NC; Malmborg, O; Pihl, O; Renmarker, K; Strand, L, 1980) |
| "This randomised, parallel group study was designed to compare the efficacy of nifedipine (40 mg once daily) combined with either the dopamine agonist, co-dergocrine mesilate (4 mg once daily) or the diuretic mefruside (25 mg once daily) in 40 patients with essential arterial hypertension and a diastolic blood pressure greater than 105 mmHg." | 5.06 | Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension. ( Heintz, B; Heller, A; Kirsten, R; Nelson, K, 1990) |
| "A study was carried out in 16 patients with moderately severe hypertension to investigate the effects of nifedipine, given alone or combined with a diuretic, on blood pressure and on renal and platelet function." | 5.06 | Effect of nifedipine and mefruside on renal function and platelet function in hypertensive patients. ( Anderton, JL; Burnet, ME; Fiskerstrand, CE; Notghi, A, 1987) |
| " Therefore the ability of the beta-receptor antagonist acebutolol (400 mg/die) and of the diuretic mefrusid (25 mg/die) to reduce exercise-induced increases in blood pressure and pressure-rate product during and after standardized ergometric work (50--100 watts) was compared in a within-patient study of 42 outpatients with arterial hypertension (stage 1 to 2, WHO) aged 18 to 50 years." | 5.05 | [The effect of beta-receptor antagonists and diuretics and their combination on blood pressure and pressure-rate product during ergometric work in hypertensive patients (author's transl)]. ( Franz, IW, 1982) |
| "Systemic BP reduction, calf blood flow and vascular resistance in the calf were determined in forty-two previously untreated patients with mild to moderate essential hypertension (WHO I-WHO II) before and after 6 weeks, 6 months and 18 months of BP-lowering treatment with mefruside (25 mg daily) or atenolol (100--400 mg daily)." | 5.04 | Blood pressure reduction and vascular adaptation. A study on long-term effects of treatment with mefruside or atenolol. ( Andersson, O; Hansson, L; Sivertsson, R, 1979) |
| "35 patients with benign essential hypertension were treated for 6 weeks with high doses of the mineralocorticoid-antagonist spironolactone (400 mg/day), or with the "loop-diuretic" mefruside (mean maximal dose 110 mg/day)." | 5.04 | [Correlations between blood pressure, blood volume and plasma renin during therapy with diuretics in essential hypertension. Comparison between the mineralocorticoid antagonist spironolactone and the "loop" diuretic mefruside]. ( Beretta-Piccoli, C; de Châtel, R; Hirsch, D; Reubi, FC; Weidmann, P, 1977) |
| "Changes in glomerular filtration rate and effective renal plasma flow following a protein meal were measured in seven patients with essential hypertension on no treatment and after 6 weeks' treatment with nifedipine and mefruside." | 3.67 | Effect of nifedipine and mefruside on renal reserve in hypertensive patients. ( Anderton, JL; Notghi, A, 1988) |
| "The antihypertensive effects of the calcium antagonist diltiazem, both alone and combined with the diuretic mefruside, were assessed over 14 months in 36 patients with essential hypertension." | 3.67 | Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension. ( Distler, A; Gotzen, R; Meyer-Sabellek, W; Röcker, L; Schulte, KL, 1987) |
| "Fifty-two middle-aged patients with essential hypertension were treated for five months with 25 mg mefruside as the only antihypertensive drug." | 3.66 | Effects of mefruside treatment in hypertension. ( Bergengren, B; Henningsen, NC; Malmborg, O; Pihl, O; Renmarker, K; Strand, L, 1980) |
| "The long-term haemodynamic effects of treatment with mefruside alone or in combination with alprenolol have been studied in nine patients with essential hypertension." | 3.65 | Haemodynamic effects of saluretic treatment and beta-receptor blockade in patients with essential hypertension. ( Bevegård, S; Castenfors, J; Danielson, M, 1977) |
| "The haemodynamic changes after 4 months' mefruside therapy in 13 patients with essential hypertension have been studied." | 3.65 | Haemodynamic effects of four months' mefruside therapy in hypertensive patients. ( Bevegård, S; Castenfors, J; Danielson, M, 1977) |
| "Muscle content of water and electrolytes (needle biopsy), intraarterial BP and cardiac output (dye dilution technique) were measured in 12 patients with essential hypertension before and after 4 months of mefruside therapy (25 mg/day)." | 3.65 | Effect of saluretic therapy on muscle content of water and electrolytes in relation to hemodynamic variables. ( Bergström, J; Bevegård, S; Castenfors, J; Danielson, M, 1977) |
| "Mefruside (25 mg/d) was administered during the 4th and 5th weeks." | 2.68 | Antihypertensive mechanism of diuretics based on pressure-natriuresis relationship. ( Kimura, G; Saito, F, 1996) |
| " Nitrendipine (mean dose 32 mg/day) and acebutolol (414 mg/day) were administered in monotherapy in increasing dosage and mefruside was added in patients not controlled by monotherapy." | 2.66 | Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks. ( Amery, A; Ditu, M; Fagard, R; Lepira, B; Lijnen, P; Lissens, W; M'Buyamba-Kabangu, JR; Staessen, J; Tshiani, KA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (88.37) | 18.7374 |
| 1990's | 5 (11.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knüchel, F | 1 |
| Antognetti, R | 1 |
| Giovine, GG | 1 |
| Frisina, N | 1 |
| Macrì, I | 1 |
| Ussi, F | 1 |
| Pirrelli, A | 1 |
| Pieri, A | 1 |
| Misceo, N | 1 |
| Stella, M | 1 |
| Strippoli, M | 1 |
| Delle Gemme, E | 1 |
| Tomasi, AM | 1 |
| Pirani, R | 1 |
| Masoni, C | 1 |
| Douglas-Jones, AP | 1 |
| Mitchell, AD | 1 |
| Waeber, B | 1 |
| Avigdor, L | 1 |
| Brunner, HR | 1 |
| Alessandrini, A | 1 |
| Bianchi, RM | 1 |
| Legnani, W | 1 |
| Renzetti, I | 1 |
| Schulte, KL | 2 |
| Meyer-Sabellek, W | 2 |
| Gotzen, R | 2 |
| Franz, IW | 2 |
| Voigt, U | 1 |
| Brommer, W | 1 |
| Ciric, D | 1 |
| Felix, G | 1 |
| Otrzonsek, G | 1 |
| Windsheimer, F | 1 |
| Schneider, B | 1 |
| Seedat, YK | 1 |
| Werkö, L | 1 |
| Henningsen, NC | 1 |
| Bergengren, B | 1 |
| Malmborg, O | 1 |
| Pihl, O | 1 |
| Renmarker, K | 1 |
| Strand, L | 1 |
| Landmark, K | 1 |
| Forsman, M | 1 |
| Lindberg, K | 1 |
| Ryman, T | 1 |
| Martmann-Moe, K | 1 |
| Haaverstad, S | 1 |
| Wiel, S | 1 |
| Saito, F | 2 |
| Kimura, G | 2 |
| Jaillard, J | 1 |
| Sivertsson, R | 2 |
| Gudbrandsson, T | 1 |
| Hansson, L | 2 |
| Krämer, KD | 1 |
| Ghabussi, P | 1 |
| Hochrein, H | 1 |
| Schnicke, M | 1 |
| Olschowka, U | 1 |
| Rezori, R | 1 |
| Harvald, B | 1 |
| Fabricius, J | 1 |
| Thomsen, A | 1 |
| Andersson, O | 1 |
| Mérier, GR | 1 |
| Baczko, A | 1 |
| Bevegård, S | 4 |
| Castenfors, J | 4 |
| Danielson, M | 4 |
| Beretta-Piccoli, C | 1 |
| Weidmann, P | 1 |
| de Châtel, R | 1 |
| Hirsch, D | 1 |
| Reubi, FC | 1 |
| Jagenburg, R | 1 |
| Landahl, S | 1 |
| Steen, B | 1 |
| Bergström, J | 1 |
| Shintani, S | 1 |
| Shiigai, T | 1 |
| Tsukagoshi, H | 1 |
| Höfling, B | 1 |
| Häringer, E | 1 |
| Herrmann, W | 1 |
| Pieske, H | 1 |
| Pieske, R | 1 |
| Philippi, M | 1 |
| Kirsten, R | 1 |
| Heller, A | 1 |
| Heintz, B | 1 |
| Nelson, K | 1 |
| Poulter, N | 1 |
| Thompson, AV | 1 |
| Sever, PS | 1 |
| Notghi, A | 2 |
| Anderton, JL | 2 |
| Fiskerstrand, CE | 1 |
| Burnet, ME | 1 |
| Shimozaki, Y | 1 |
| Fujii, T | 1 |
| Ishii, T | 1 |
| Yoshida, K | 1 |
| Abe, H | 1 |
| Kawamura, M | 1 |
| Deguchi, F | 1 |
| Kawano, Y | 1 |
| Röcker, L | 1 |
| Distler, A | 1 |
| M'Buyamba-Kabangu, JR | 1 |
| Fagard, R | 1 |
| Lijnen, P | 1 |
| Staessen, J | 1 |
| Lissens, W | 1 |
| Ditu, M | 1 |
| Lepira, B | 1 |
| Tshiani, KA | 1 |
| Amery, A | 1 |
| Wardemann, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Once Versus Twice Daily Electrolyte Monitoring in CHF; a Study Monitoring Electrolytes in Congestive Heart Failure Patients Being Actively Diuresed in Hospital[NCT02497742] | 96 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 trials available for mefruside and Blood Pressure, High
| Article | Year |
|---|---|
[Clinical and statistical considerations on a new drug in the therapy of arterial hypertension. Controlled study].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Female; Guanabenz; Guan | 1984 |
[Treatment of arterial hypertension with a new drug combining guanabenz-mefruside].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Dose-Response Relationship, Drug; Drug Administrat | 1984 |
[Clinical use of various dosages of a centrally acting hypotensive drug associated with a diuretic].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Tolerance; Female; Guanabe | 1984 |
[Treatment of idiopathic hypertension with guanabenz-mefruside].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Dose-Response Relationship, Drug; Drug Combination | 1984 |
Comparison of nifedipine (retard formulation) and mefruside in the treatment of mild to moderate hypertension--a prospective randomized double-blind crossover study in general practice.
Topics: Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Humans; Hypertension; Male; Mefrus | 1984 |
[Evaluation of a drug combination for antihypertensive therapy in general practice].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Humans; | 1981 |
[The effect of beta-receptor antagonists and diuretics and their combination on blood pressure and pressure-rate product during ergometric work in hypertensive patients (author's transl)].
Topics: Acebutolol; Adolescent; Adult; Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Heart R | 1982 |
[Long-term antihypertensive therapy with Etozoline].
Topics: Adult; Drug Evaluation; Female; Humans; Hypertension; Inositol; Male; Mefruside; Middle Aged; Reserp | 1980 |
An evaluation of debrisoquine and mefruside in the treatment of hypertension in African and Indian patients.
Topics: Adult; Aged; Debrisoquin; Diuretics; Double-Blind Method; Drug Combinations; Drug Evaluation; Female | 1980 |
Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters.
Topics: Aged; Blood Pressure; Brain; Cardiac Output; Cerebrovascular Circulation; Double-Blind Method; Femal | 1995 |
Antihypertensive mechanism of diuretics based on pressure-natriuresis relationship.
Topics: Aged; Blood Pressure; Body Weight; Diuretics; Female; Humans; Hypertension; Male; Mefruside; Middle | 1996 |
Combination therapy with saluretics and atenolol in essential hypertension. Effects on blood pressure, electrolytes and uric acid.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Bendroflumethiazide; Chlorthalidone; Diuretics; | 1979 |
[Antihypertensive combination-therapy with inositol nicotinate in essential hypertension].
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Femal | 1977 |
[Mild and medium severe hypertension. Treatment of mild and medium severe hypertension with bendigon mite].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans | 1979 |
Haemodynamic parameters in hypertensive patients treated with a diuretic and with a diuretic in combination with a beta-blocker.
Topics: Adult; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Evaluation; Drug Therapy, Comb | 1979 |
Blood pressure reduction and vascular adaptation. A study on long-term effects of treatment with mefruside or atenolol.
Topics: Adult; Atenolol; Blood Pressure Determination; Diuretics; Female; Humans; Hypertension; Male; Mefrus | 1979 |
[Clinical assay of a debrisoquine-diuretic compound when treating moderate arterial hypertension (author's transl)].
Topics: Adult; Aged; Debrisoquin; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hypertensio | 1979 |
[Correlations between blood pressure, blood volume and plasma renin during therapy with diuretics in essential hypertension. Comparison between the mineralocorticoid antagonist spironolactone and the "loop" diuretic mefruside].
Topics: Blood Pressure; Blood Volume; Creatinine; Diuretics; Female; Humans; Hypertension; Male; Mefruside; | 1977 |
[Therapy of mild to moderate hypertension. Efficacy and tolerance of Amlodipine in comparison with the combination nifedipine/mefruside].
Topics: Adult; Aged; Amlodipine; Calcium Channel Blockers; Drug Combinations; Female; Humans; Hypertension; | 1991 |
Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Dihydroergotoxine; Drug Ther | 1990 |
A double-blind, placebo-controlled, crossover trial to investigate the additive hypotensive effect of a diuretic (mefruside) to that produced by nifedipine.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Synergis | 1987 |
Effect of nifedipine and mefruside on renal function and platelet function in hypertensive patients.
Topics: Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hy | 1987 |
Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks.
Topics: Acebutolol; Adolescent; Adult; Aged; Black or African American; Body Weight; Double-Blind Method; Dr | 1987 |
20 other studies available for mefruside and Blood Pressure, High
| Article | Year |
|---|---|
[Effect of beta-receptor blocking agents and diuretics and their combination on blood pressure during rest and exertion].
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Diuretics; Drug Combinations; Female; Humans; Hyp | 1982 |
Long-term follow-up study of hypertensive patients by practicing internists after a controlled drug trial.
Topics: Antihypertensive Agents; Blood Pressure; Debrisoquin; Double-Blind Method; Drug Therapy, Combination | 1984 |
[Effects of the short-term administration of a new preparation in the treatment of arterial hypertension].
Topics: Aged; Diuretics; Drug Evaluation; Drug Therapy, Combination; Female; Guanabenz; Guanidines; Humans; | 1984 |
Effects of acebutolol combined with mefruside on total-body and serum potassium in essential hypertensive patients.
Topics: Acebutolol; Adult; Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertensio | 1984 |
[Hypertension treatment: weight reduction training or drugs?].
Topics: Acebutolol; Adolescent; Adult; Blood Pressure; Diet, Reducing; Diuretics; Female; Humans; Hypertensi | 1983 |
[Hypertension treatment in a health resort].
Topics: Adult; Diuretics; Drug Combinations; Female; Health Resorts; Humans; Hypertension; Male; Mefruside; | 1981 |
Vascular adaptation to long-term blood pressure reduction.
Topics: Atenolol; Blood Pressure; Diuretics; Humans; Hypertension; Mefruside; Propanolamines; Vascular Resis | 1980 |
Effects of mefruside treatment in hypertension.
Topics: Aged; Blood Glucose; Cholesterol; Diuretics; Female; Humans; Hypertension; Male; Mefruside; Middle A | 1980 |
[Clinical experimentation with tensid (apropos of 60 cases)].
Topics: Adult; Aged; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hypertension; Inositol; | 1976 |
Peripheral haemodynamics in essential hypertension.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Blood Pressure; Cardiac Output; Hemodynamics; Huma | 1977 |
Carotid baroreceptor function in hypertensive patients.
Topics: Adult; Alprenolol; Blood Pressure; Cardiac Output; Carotid Sinus; Female; Heart Rate; Humans; Hypert | 1977 |
Haemodynamic effects of saluretic treatment and beta-receptor blockade in patients with essential hypertension.
Topics: Adult; Alprenolol; Blood Pressure; Cardiac Output; Diuretics; Drug Therapy, Combination; Female; Fol | 1977 |
Haemodynamic effects of four months' mefruside therapy in hypertensive patients.
Topics: Adult; Blood Pressure; Cardiac Output; Diuretics; Female; Follow-Up Studies; Heart Rate; Hemodynamic | 1977 |
[Blood pressure and serum potassium during 6 months of mefruside treatment].
Topics: Diuretics; Drug Evaluation; Female; Humans; Hypertension; Hypokalemia; Male; Mefruside; Potassium; T | 1977 |
Effect of saluretic therapy on muscle content of water and electrolytes in relation to hemodynamic variables.
Topics: Adult; Blood Pressure; Body Water; Cardiac Output; Diuretics; Female; Hemodynamics; Humans; Hyperten | 1977 |
Marked hypokalemic rhabdomyolysis with myoglobinuria due to diuretic treatment.
Topics: Aged; Biopsy; Electrocardiography; Furosemide; Humans; Hypertension; Hypokalemia; Male; Mefruside; M | 1991 |
Effect of nifedipine and mefruside on renal reserve in hypertensive patients.
Topics: Adult; Dietary Proteins; Diuretics; Glomerular Filtration Rate; Humans; Hypertension; Mefruside; Mid | 1988 |
[Mechanism of hypotensive action of a diuretic, mefruside, based on the pressure-natriuresis relationship].
Topics: Aged; Blood Pressure; Diet, Sodium-Restricted; Diuretics; Female; Humans; Hypertension; Kidney; Male | 1987 |
Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension.
Topics: Adult; Blood Pressure; Carbohydrate Metabolism; Diltiazem; Diuretics; Drug Therapy, Combination; Fem | 1987 |
[Clinical studies with a new antihypertensive agent, Bendigon].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Combinations; Drug Synergism; | 1970 |