mefloquine hydrochloride has been researched along with Malaria, Falciparum in 16 studies
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine (CQ) has been used as first line malaria therapeutic drug for decades." | 3.81 | Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives. ( Caridha, D; Gerena, L; Korotchenko, V; Kreishman-Deitrick, M; Li, Q; Lin, AJ; Sathunuru, R; Smith, PL, 2015) |
| "Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatments highly ineffective." | 3.76 | Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. ( Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B, 2010) |
| "Gedunin was extracted in quantity, and nine derivatives prepared for a structure-activity study, which revealed essential functionalities for activity." | 1.30 | Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. ( Angerhofer, C; Arnason, JT; Durst, T; Gbeassor, M; MacKinnon, S; Pezzuto, J; Poveda, LJ; Sanchez-Vindas, PE, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MacKinnon, S | 1 |
| Durst, T | 1 |
| Arnason, JT | 1 |
| Angerhofer, C | 1 |
| Pezzuto, J | 1 |
| Sanchez-Vindas, PE | 1 |
| Poveda, LJ | 1 |
| Gbeassor, M | 1 |
| Avery, MA | 1 |
| Muraleedharan, KM | 1 |
| Desai, PV | 1 |
| Bandyopadhyaya, AK | 1 |
| Furtado, MM | 1 |
| Tekwani, BL | 1 |
| Skinner-Adams, TS | 2 |
| Andrews, KT | 3 |
| Melville, L | 1 |
| McCarthy, J | 1 |
| Gardiner, DL | 2 |
| Noedl, H | 1 |
| Krudsood, S | 1 |
| Leowattana, W | 1 |
| Tangpukdee, N | 1 |
| Thanachartwet, W | 1 |
| Looareesuwan, S | 1 |
| Miller, RS | 1 |
| Fukuda, M | 1 |
| Jongsakul, K | 1 |
| Yingyuen, K | 1 |
| Sriwichai, S | 1 |
| Ohrt, C | 1 |
| Knirsch, C | 1 |
| Baniecki, ML | 1 |
| Wirth, DF | 1 |
| Clardy, J | 1 |
| Savini, H | 1 |
| Bogreau, H | 1 |
| Bertaux, L | 1 |
| Bouchiba, H | 1 |
| Kraemer, P | 1 |
| Parzy, D | 1 |
| Garnotel, E | 1 |
| Rogier, C | 1 |
| Simon, F | 1 |
| Pradines, B | 1 |
| Lek-Uthai, U | 1 |
| Suwanarusk, R | 1 |
| Ruengweerayut, R | 1 |
| Nosten, F | 1 |
| Boonma, P | 1 |
| Piera, KA | 1 |
| Machunter, B | 1 |
| McCarthy, JS | 1 |
| Anstey, NM | 1 |
| Price, RN | 1 |
| Russell, B | 1 |
| Dow, GS | 1 |
| Chen, Y | 1 |
| Caridha, D | 2 |
| Gerena, L | 3 |
| Gettayacamin, M | 1 |
| Johnson, J | 1 |
| Li, Q | 2 |
| Melendez, V | 1 |
| Obaldia, N | 1 |
| Tran, TN | 1 |
| Kozikowski, AP | 1 |
| Bacon, DJ | 1 |
| McCollum, AM | 1 |
| Griffing, SM | 1 |
| Salas, C | 1 |
| Soberon, V | 1 |
| Santolalla, M | 1 |
| Haley, R | 1 |
| Tsukayama, P | 1 |
| Lucas, C | 1 |
| Escalante, AA | 1 |
| Udhayakumar, V | 1 |
| Grimberg, BT | 1 |
| Jaworska, MM | 1 |
| Hough, LB | 1 |
| Zimmerman, PA | 1 |
| Phillips, JG | 1 |
| Dong, Y | 1 |
| Wittlin, S | 2 |
| Sriraghavan, K | 1 |
| Chollet, J | 1 |
| Charman, SA | 1 |
| Charman, WN | 1 |
| Scheurer, C | 1 |
| Urwyler, H | 1 |
| Santo Tomas, J | 1 |
| Snyder, C | 1 |
| Creek, DJ | 1 |
| Morizzi, J | 1 |
| Koltun, M | 1 |
| Matile, H | 1 |
| Wang, X | 1 |
| Padmanilayam, M | 1 |
| Tang, Y | 1 |
| Dorn, A | 1 |
| Brun, R | 2 |
| Vennerstrom, JL | 1 |
| Nzila, A | 1 |
| Rottmann, M | 1 |
| Chitnumsub, P | 1 |
| Kiara, SM | 1 |
| Kamchonwongpaisan, S | 1 |
| Maneeruttanarungroj, C | 1 |
| Taweechai, S | 1 |
| Yeung, BK | 1 |
| Goh, A | 1 |
| Lakshminarayana, SB | 1 |
| Zou, B | 1 |
| Wong, J | 1 |
| Ma, NL | 1 |
| Weaver, M | 1 |
| Keller, TH | 1 |
| Dartois, V | 1 |
| Yuthavong, Y | 1 |
| Diagana, TT | 1 |
| Chen, N | 1 |
| Chavchich, M | 1 |
| Peters, JM | 1 |
| Kyle, DE | 1 |
| Gatton, ML | 1 |
| Cheng, Q | 1 |
| Gutteridge, CE | 1 |
| Hoffman, MM | 1 |
| Bhattacharjee, AK | 1 |
| Milhous, WK | 1 |
| Gorka, AP | 1 |
| de Dios, A | 1 |
| Roepe, PD | 1 |
| Korotchenko, V | 1 |
| Sathunuru, R | 1 |
| Kreishman-Deitrick, M | 1 |
| Smith, PL | 1 |
| Lin, AJ | 1 |
1 review available for mefloquine hydrochloride and Malaria, Falciparum
| Article | Year |
|---|---|
Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities.
Topics: Antimalarials; Crystallization; Drug Resistance; Heme; Hemeproteins; Humans; Malaria, Falciparum; Mo | 2013 |
15 other studies available for mefloquine hydrochloride and Malaria, Falciparum
| Article | Year |
|---|---|
Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives.
Topics: Animals; Antimalarials; Cell Survival; Chloroquine; Drug Resistance; Humans; KB Cells; Limonins; Mal | 1997 |
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Clone Cells; Drug Design; Inhibitory Con | 2003 |
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Chloroquine; Drug Synergism; HIV Protease Inhibitors; Humans; Malaria, Falci | 2007 |
In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Azithromycin; Clinical Trials, Phase II as Topic; | 2007 |
High-throughput Plasmodium falciparum growth assay for malaria drug discovery.
Topics: Animals; Biological Assay; Child, Preschool; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resi | 2007 |
First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros.
Topics: Animals; Antimalarials; Atovaquone; Comoros; Drug Resistance; France; Genotype; Humans; Malaria, Fal | 2008 |
Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum.
Topics: Animals; Antimalarials; Drug Resistance, Multiple; Gene Dosage; Genes, MDR; Genes, Protozoan; HIV In | 2008 |
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.
Topics: Animals; Antimalarials; Aotidae; Drug Resistance; Enzyme Inhibitors; Histone Deacetylase Inhibitors; | 2008 |
Dynamics of malaria drug resistance patterns in the Amazon basin region following changes in Peruvian national treatment policy for uncomplicated malaria.
Topics: Animals; Antimalarials; Drug Resistance; Genotype; Haplotypes; Health Policy; Humans; Malaria, Falci | 2009 |
Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.
Topics: Animals; Antimalarials; DNA, Protozoan; Drug Discovery; Drug Resistance; Erythrocytes; Flow Cytometr | 2009 |
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Topics: Animals; Antimalarials; Heterocyclic Compounds, 1-Ring; Malaria, Falciparum; Mice; Molecular Conform | 2010 |
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Foli | 2010 |
Deamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro.
Topics: Animals; Antimalarials; Artemisinins; Chromosomes; Drug Resistance; Gene Amplification; Gene Dosage; | 2010 |
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones.
Topics: Aminoquinolines; Antimalarials; Chalcones; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum | 2011 |
Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives.
Topics: Animals; Antimalarials; Hep G2 Cells; Humans; Malaria; Malaria, Falciparum; Male; Mice; Naphthyridin | 2015 |