mefenamic acid has been researched along with Seizures in 11 studies
Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain." | 7.67 | Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Ikonomidou-Turski, C; Kleinrok, Z; Turski, L; Turski, WA, 1988) |
| "Antidepressants were frequently associated with seizures in overdose, but other pharmaceuticals, as mefenamic acid, were also associated with seizures in a considerable number of cases." | 3.80 | Seizures after single-agent overdose with pharmaceutical drugs: analysis of cases reported to a poison center. ( Ceschi, A; Kupferschmidt, H; Monnet-Tschudi, F; Rauber-Lüthy, C; Reichert, C; Reichert, P, 2014) |
| "The muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain." | 3.67 | Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Ikonomidou-Turski, C; Kleinrok, Z; Turski, L; Turski, WA, 1988) |
| "A 22 year old heroin addict was admitted with tonic-clonic seizures, confusion and agitation 10 hours after taking mefenamic acid 5 grams orally and 2." | 3.67 | A case of intravenous and oral mefenamic acid poisoning. ( Canning, GP; McKillop, G, 1987) |
| "Additionally, FMZ prevented catalepsy, significantly restored locomotor activity, reduced seizure intensity (seizure score = 0." | 1.91 | Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice. ( Aburass, H; Alfaqih, H; Ardianto, C; Ayoub, R; Goh, KW; Jarrar, Q; Jarrar, Y; Ming, LC; Moshawih, S, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Jarrar, Q | 1 |
| Ayoub, R | 1 |
| Jarrar, Y | 1 |
| Aburass, H | 1 |
| Goh, KW | 1 |
| Ardianto, C | 1 |
| Ming, LC | 1 |
| Moshawih, S | 1 |
| Alfaqih, H | 1 |
| Reichert, C | 1 |
| Reichert, P | 1 |
| Monnet-Tschudi, F | 1 |
| Kupferschmidt, H | 1 |
| Ceschi, A | 1 |
| Rauber-Lüthy, C | 1 |
| Balasubramanian, S | 1 |
| Sumanth, A | 1 |
| Kingswell, RS | 1 |
| Prescott, LF | 1 |
| Balali-Mood, M | 1 |
| Critchley, JA | 1 |
| Proudfoot, AT | 2 |
| Frank, JJ | 1 |
| Wightkin, WT | 1 |
| Hubner, JW | 1 |
| Robson, RH | 1 |
| Balali, M | 1 |
| Critchley, J | 1 |
| Prescott, L | 1 |
| Ikonomidou-Turski, C | 1 |
| Cavalheiro, EA | 1 |
| Turski, L | 1 |
| Bortolotto, ZA | 1 |
| Kleinrok, Z | 1 |
| Calderazzo-Filho, LS | 1 |
| Turski, WA | 1 |
| McKillop, G | 1 |
| Canning, GP | 1 |
| Wallenstein, MC | 1 |
| Done, AK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure (CASTox): a Pilot Study[NCT03310697] | 48 participants (Actual) | Interventional | 2017-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for mefenamic acid and Seizures
| Article | Year |
|---|---|
Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice.
Topics: Animals; Behavior, Animal; Catalepsy; Central Nervous System; Flumazenil; gamma-Aminobutyric Acid; M | 2023 |
Seizures after single-agent overdose with pharmaceutical drugs: analysis of cases reported to a poison center.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidepressive Agents; Child; Child, Presch | 2014 |
Mefenamic acid--role as antipyretic.
Topics: Analgesics, Non-Narcotic; Child; Colitis; Humans; Mefenamic Acid; Seizures | 2010 |
Mefenamic acid overdose.
Topics: Humans; Mefenamic Acid; Seizures | 1981 |
Avoidance of mefenamic acid in epilepsy.
Topics: Epilepsy; Humans; Mefenamic Acid; Seizures | 1981 |
Acute toxicity of nonsteroidal antiinflammatory agents: seizure following a mefenamic acid overdose.
Topics: Adult; Female; Humans; Mefenamic Acid; Seizures | 1983 |
Mefenamic acid poisoning and epilepsy.
Topics: Adolescent; Female; Humans; Mefenamic Acid; Seizures | 1979 |
Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Male; Mefenamic Acid; Phenylbutazone; Piloc | 1988 |
A case of intravenous and oral mefenamic acid poisoning.
Topics: Administration, Oral; Adult; Confusion; Heroin; Humans; Injections, Intravenous; Male; Mefenamic Aci | 1987 |
Differential effect of prostaglandin synthetase inhibitor pretreatment on pentylenetetrazol-induced seizures in rat.
Topics: Acetaminophen; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Electric Stimulation; Electroen | 1985 |
Antipyretics.
Topics: Acetaminophen; Analgesics; Aspirin; Child; Health Education; Humans; Indomethacin; Mefenamic Acid; P | 1972 |