mefenamic acid has been researched along with Innate Inflammatory Response in 38 studies
Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mefenamic acid is a non-steroidal anti-inflammatory drug able to control the symptoms of osteoarthritis (OA), but its effects on protection of cartilage and bone are still unclear." | 7.83 | Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis. ( Aguiar, GC; Amaral, FA; Caliari, MV; Ferreira, AJ; Queiroz-Junior, CM; Sitta, GL; Teixeira, MM, 2016) |
| "Mefenamic acid treatment provided significant protection against the elevation of lipid peroxidation, protein oxidation, levels of TNF-α, IL-1β and Bax." | 5.38 | Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis. ( Armagan, G; Kanit, L; Turunc, E; Yalcin, A, 2012) |
| "Mefenamic acid is a non-steroidal anti-inflammatory drug able to control the symptoms of osteoarthritis (OA), but its effects on protection of cartilage and bone are still unclear." | 3.83 | Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis. ( Aguiar, GC; Amaral, FA; Caliari, MV; Ferreira, AJ; Queiroz-Junior, CM; Sitta, GL; Teixeira, MM, 2016) |
| " Flufenamic acid and mefenamic acid are efficacious in NLRP3-dependent rodent models of inflammation in air pouch and peritoneum." | 3.83 | Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models. ( Allan, SM; Bagnall, J; Baldwin, AG; Booth, SJ; Brough, D; Daniels, MJ; Eder, C; Fasolino, V; Fischer, N; Freeman, S; Galea, J; Harte, MK; Jackson, J; Koziel, V; Latta, C; Lawrence, CB; Paszek, P; Pillot, T; Rivers-Auty, J; Schilling, T; Spencer, NG; Watremez, W; White, CS; Wong, R; Yu, S, 2016) |
| "In experiments on rats the antiphlogistic action of sodium mephenaminate and salicylate was found to be more pronounced under conditions of ovalbumin than that of dextran inflammation." | 3.65 | [Role of bioenergetic changes in the mechanism of action of nonsteroid anti-inflammatory agents]. ( Leschinskiĭ, AF, 1976) |
| " Their similarities in therapeutic action (anti-inflammation) and metabolic pathways (phase II metabolisms) may lead to co-administration by patients with the potential of pharmacokinetic and/or pharmacodynamic interactions." | 1.42 | Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats. ( Fong, SY; Wong, YC; Xie, C; Zuo, Z, 2015) |
| "Mefenamic acid treatment provided significant protection against the elevation of lipid peroxidation, protein oxidation, levels of TNF-α, IL-1β and Bax." | 1.38 | Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis. ( Armagan, G; Kanit, L; Turunc, E; Yalcin, A, 2012) |
| "Inflammation is deleterious for organs with reduced capacity of regeneration, such as the brain." | 1.38 | Effects of non-steroidal antiinflammatory drugs on D-serine-induced oxidative stress in vitro. ( Armagan, G; Kanit, L; Yalcin, A, 2012) |
| "Circular burns were inflicted on anaesthetized animals which were killed 30 min, 2 h or 4 h after burning." | 1.26 | On the enzymatic response to injury and its mediators. ( Nieminen, L; Raekallio, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (60.53) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 11 (28.95) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Maccari, R | 1 |
| Ottanà, R | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Zhang, X | 1 |
| Xu, A | 1 |
| Lv, J | 1 |
| Zhang, Q | 1 |
| Ran, Y | 1 |
| Wei, C | 1 |
| Wu, J | 1 |
| Kasture, P | 1 |
| Mehta, K | 1 |
| Gowda, A | 1 |
| Aguiar, GC | 1 |
| Queiroz-Junior, CM | 1 |
| Sitta, GL | 1 |
| Amaral, FA | 1 |
| Teixeira, MM | 1 |
| Caliari, MV | 1 |
| Ferreira, AJ | 1 |
| Brignardello-Petersen, R | 1 |
| Fong, SY | 1 |
| Wong, YC | 1 |
| Xie, C | 1 |
| Zuo, Z | 1 |
| Cunha, VR | 1 |
| Guilherme, VA | 1 |
| de Paula, E | 1 |
| de Araujo, DR | 1 |
| Silva, RO | 1 |
| Medeiros, JV | 1 |
| Leite, JR | 1 |
| Petersen, PA | 1 |
| Foldvari, M | 1 |
| Petrilli, HM | 1 |
| Constantino, VR | 1 |
| Daniels, MJ | 1 |
| Rivers-Auty, J | 1 |
| Schilling, T | 1 |
| Spencer, NG | 1 |
| Watremez, W | 1 |
| Fasolino, V | 1 |
| Booth, SJ | 1 |
| White, CS | 1 |
| Baldwin, AG | 1 |
| Freeman, S | 1 |
| Wong, R | 1 |
| Latta, C | 1 |
| Yu, S | 1 |
| Jackson, J | 1 |
| Fischer, N | 1 |
| Koziel, V | 1 |
| Pillot, T | 1 |
| Bagnall, J | 1 |
| Allan, SM | 1 |
| Paszek, P | 1 |
| Galea, J | 1 |
| Harte, MK | 1 |
| Eder, C | 1 |
| Lawrence, CB | 1 |
| Brough, D | 1 |
| Moradi, A | 1 |
| Navidpour, L | 1 |
| Amini, M | 1 |
| Sadeghian, H | 1 |
| Shadnia, H | 1 |
| Firouzi, O | 1 |
| Miri, R | 1 |
| Ebrahimi, SE | 1 |
| Abdollahi, M | 1 |
| Zahmatkesh, MH | 1 |
| Shafiee, A | 1 |
| Armagan, G | 2 |
| Turunc, E | 1 |
| Kanit, L | 2 |
| Yalcin, A | 2 |
| WINDER, CV | 2 |
| WAX, J | 2 |
| SCOTTI, L | 1 |
| SCHERRER, RA | 1 |
| JONES, EM | 1 |
| SHORT, FW | 1 |
| WELFORD, M | 1 |
| Mörsdorf, K | 2 |
| Cornelissen, G | 1 |
| Adachi, K | 1 |
| Asanuma, M | 1 |
| Nishibayashi-Asanuma, S | 1 |
| Miyazaki, I | 1 |
| Kohno, M | 1 |
| Ogawa, N | 1 |
| Raekallio, J | 1 |
| Nieminen, L | 1 |
| Leschinskiĭ, AF | 1 |
| Akatsu, T | 1 |
| Catanzaro Guimarães, SA | 1 |
| Roubal, Z | 1 |
| Grimová, J | 1 |
| Nĕmecek, O | 1 |
| Cepelák, V | 1 |
| Anspach, K | 1 |
| Iizuka, Y | 1 |
| Tanaka, K | 1 |
| Bacon, PA | 1 |
| Dieppe, PA | 1 |
| Wawrzyńska-Pagowska, J | 1 |
| Willoughby, DA | 1 |
| DiRosa, M | 1 |
| Di Perri, T | 1 |
| Auteri, A | 1 |
| Tsurumi, K | 2 |
| Hiramatsu, Y | 2 |
| Nozaki, M | 1 |
| Hayashi, M | 2 |
| Shibuya, T | 2 |
| Yamaguchi, A | 1 |
| Kimura, S | 1 |
| Kaump, DH | 1 |
| Trinus, FP | 1 |
| Tarnavskaia, MI | 1 |
| Kirichek, LM | 1 |
| Arrigoni-Martelli, E | 1 |
| Schiatti, P | 1 |
| Selva, D | 1 |
| Nakanishi, M | 1 |
| Imamura, H | 1 |
| Ikegami, K | 1 |
| Goto, K | 1 |
| Nakamura, H | 1 |
| Kadokawa, T | 1 |
| Nakatsuji, K | 1 |
| Nakamura, K | 1 |
| Jahn, U | 1 |
| Adrian, RW | 1 |
4 reviews available for mefenamic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases.
Topics: Humans; Inflammasomes; Inflammation; Molecular Structure; NLR Family, Pyrin Domain-Containing 3 Prot | 2020 |
[Clinical use of non-steroid anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arthritis, Rheumatoid; Aspirin; Cell Mi | 1974 |
[Non-steroidal anti-inflammatory drugs for eye diseases].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Child; Child, Preschool; Enzyme Therapy; Eye Diseases; | 1968 |
1 trial available for mefenamic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Skin testing in the assessment of antiinflammatory drugs in man.
Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Flufenamic Acid; Histamine; Humans; Hypersensiti | 1972 |
33 other studies available for mefenamic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Diabetes Complications; Diabetes Mellitus; Enzyme Inhibito | 2015 |
Inflammasome, Inflammation, Infection and Mefenamic Acid.
Topics: Humans; Inflammasomes; Inflammation; Ions; Macrophages; Mefenamic Acid; NLR Family, Pyrin Domain-Con | 2022 |
Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Cartilage; Disease Models, Animal; | 2016 |
Curcumin probably does not reduce pain importantly after impacted mandibular third-molar surgery compared with mefenamic acid.
Topics: Curcumin; Humans; Inflammation; Mefenamic Acid; Molar; Molar, Third; Pain; Tooth Extraction; Tooth, | 2019 |
Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cell Line; Chromatography, Liqui | 2015 |
Delivery system for mefenamic acid based on the nanocarrier layered double hydroxide: Physicochemical characterization and evaluation of anti-inflammatory and antinociceptive potential.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Drug Carriers; Edema; | 2016 |
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Cell Death; | 2016 |
Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cy | 2010 |
Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain; Inflammation; Mefenamic Acid; Ne | 2012 |
Effects of non-steroidal antiinflammatory drugs on D-serine-induced oxidative stress in vitro.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Inflammation; Lipid Peroxida | 2012 |
Anti-inflammatory, antipyretic and antinociceptive properties of N-(2,3-xylyl)anthranilic acid (mefenamic acid).
Topics: Analgesics; Anaphylaxis; Anti-Inflammatory Agents; Antipyretics; Humans; Inflammation; Mefenamic Aci | 1962 |
ANTI-INFLAMMATORY AND ANTIPYRETIC PROPERTIES OF N-(2,6-DICHLORO-M-TOLYL)ANTHRANILIC ACID (CI-583).
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Aspirin; | 1965 |
Discussion on the pharmacology of the fenamates.
Topics: Abnormalities, Drug-Induced; Analgesia; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; As | 1966 |
[Contribution to the evaluation of anti-inflammatory agents in vitro].
Topics: Animals; Anti-Inflammatory Agents; Cortisone; Esterases; Flufenamic Acid; Indomethacin; Inflammation | 1966 |
A device for automatic measurement of writhing and its application to the assessment of analgesic agents.
Topics: Acetates; Acetic Acid; Aminopyrine; Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models, | 1994 |
Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoates; Cell Death; | 2001 |
On the enzymatic response to injury and its mediators.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Burns; | 1979 |
[Role of bioenergetic changes in the mechanism of action of nonsteroid anti-inflammatory agents].
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Anti-Inflammatory | 1976 |
Comparative effects of non-steroidal anti-inflammatory drugs, mefenamic acid, metiazinic acid and glucametacin on the inflammatory response induced by subcutaneous implantation of human dental plaque and on the mitotic activity of isoproterenol-stimulated
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dental Plaque; Female; Humans; Indomethacin; Infla | 1986 |
Effects of nonsteroid anti-inflammatory agents and some dicoumarol derivatives on platelet aggregation, fibrinolysis and stabilization of cell membrane in vitro.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cell Membrane; Chloroquine; Coumarins; Depressio | 1972 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
][A new method for screening of analgesics applied to heat induced inflammatory pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Burns; Drug Evaluation, Preclinical; Flufenamic Acid; Hab | 1974 |
Studies on the mode of action of non-steroid anti-inflammatory drugs.
Topics: Animals; Aspirin; Cell Movement; Disease Models, Animal; Indomethacin; Inflammation; Leukocytes; Mef | 1972 |
[Anti-complement activity in vitro and in vivo of some non-steroid anti-inflammatory drugs].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Complement Inactivator Proteins; Flufenamic Acid; Hemoly | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 1. On acute inflammation].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Electrolytes; Eryth | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 2. On subacute inflammation].
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Body Weight; Ed | 1973 |
Experimental observations on flufenamic, mefanamic and meclofenamic acids. II. Toxicology in animals.
Topics: Aluminum; Animals; Anti-Inflammatory Agents; Calcium; Colon; Dogs; Edema; Female; Flufenamic Acid; F | 1966 |
[A comparative evaluation of the anti-inflammatory effect of sodium mephenaminate with analgin and sodium salicylate].
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Drug Synergism; Inflammation; | 1972 |
The influence of anti-inflammatory and immunosuppressant drugs on Nystatin induced oedema.
Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Ch | 1971 |
Pharmacological investigations of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine.
Topics: Acid Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents; Antibody Formation; Aspirin; Blood | 1970 |
Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity.
Topics: Aminopyrine; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Capill | 1970 |
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine].
Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo | 1969 |