mefenamic acid has been researched along with Fever in 20 studies
Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the interaction of S-methylisothiourea (a selective inducible nitric oxide synthase inhibitor) with rofecoxib (selective cyclooxygenase-2 inhibitor) and mefenamic acid (non-selective cyclooxygenase inhibitor) in Brewer's yeast-induced pyrexia in mice by isobolographic analysis." | 3.73 | Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study. ( Bhat, AS; Krishna, V; Kumar, D; Prakash, VR; Tandan, SK, 2005) |
| "Administration of acetylsalicylic acid or mefenamic acid during experimental infection of rabbits with a rabbit-adapted strain of rinderpest virus did not prevent initiation of the febrile response but significantly reduced the duration of fever." | 3.67 | Effects of antipyretics in rinderpest virus infection in rabbits. ( Kobune, F; Kurosawa, S; Okuyama, K; Sugiura, A, 1987) |
| "Acetylsalicylic acid (300 mg/kg), mefenamic acid (30 mg/kg) or indomethacin (20 mg/kg) given orally in the doses preventing the postpyrogenic fever, inhibited the stimulatory effect of LPS on phagocytic and killing activity of neutrophils." | 3.67 | Inhibition of postpyrogenic increase of phagocytic and killing activity of neutrophils by nonsteroid antiinflammatory drugs. ( Debowy, J; Garbuliński, T; Obmińska-Domoradzka, B; Switała, M, 1988) |
| "The antipyretic activity of three N-aryl-anthranilic acid derivatives, mefenamic acid, tolfenamic acid and flufenamic acid, was compared and their optimal antipyretic dose determined in a trial in 87 children (aged 5 months to 15 years), who suffered from infections and fever exceeding 38." | 3.66 | Oral antipyretic therapy: evaluation of the N-aryl-anthranilic acid derivatives mefenamic acid, tolfenamic acid and flufenamic acid. ( Keinänen, S; Kouvalainen, K; Similä, S, 1978) |
| "The capacity of N-(2,3-xylyl)anthranilic acid (mefenamic acid) to reduce fever in children was compared with that of acetylsalicylic acid, paracetamol and amino-phenazone." | 3.65 | Oral antipyretic therapy. Evaluation of mefenamic acid (short communication). ( Keinänen, S; Kouvalainen, K; Similä, S, 1977) |
| "Fever is an important symptom of underlying disease condition and in general is considered harmful in pediatric age group as it may lead to febrile seizures, stupor, dehydration increase work of breathing, discomfort and tachycardia." | 2.41 | Antipyretics in children. ( Bhatnagar, SK; Chandra, J, 2002) |
| "Acute renal failure is commonly seen in adults after treatment with analgesic agents." | 1.35 | Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs. ( Baskin, E; Bayrakci, US; Cengiz, N; Erçoban, HS; Melek, E; Onay, OS, 2009) |
| "The CYP content in the mefenamic acid-treated fevered rat was also lower than that in the control." | 1.30 | Effect of interleukin 1 beta-induced fever on hepatic drug metabolism in rat. ( Kihara, T; Ono, N; Shigematsu, H; Shimeno, H; Soeda, S; Toda, A; Umesue, I, 1998) |
| "Fever was induced by intravenous injection of lipopolysaccharide (LPS) of E." | 1.28 | Influence of nonsteroid anti-inflammatory drugs on lymphocyte subpopulation and on the primary humoral response in normothermic and feverish rabbits. ( Debowy, J; Garbuliński, T; Obmińska-Domoradzka, B; Switała, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (60.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uramaru, N | 1 |
| Shigematsu, H | 2 |
| Toda, A | 2 |
| Eyanagi, R | 1 |
| Kitamura, S | 1 |
| Ohta, S | 1 |
| Dewan, P | 1 |
| Gupta, P | 1 |
| Onay, OS | 1 |
| Erçoban, HS | 1 |
| Bayrakci, US | 1 |
| Melek, E | 1 |
| Cengiz, N | 1 |
| Baskin, E | 1 |
| Bhat, AS | 1 |
| Tandan, SK | 1 |
| Kumar, D | 1 |
| Krishna, V | 1 |
| Prakash, VR | 1 |
| Weiss, CF | 1 |
| Harris, ST | 1 |
| Khubchandani, RP | 1 |
| Ghatikar, KN | 1 |
| Keny, S | 1 |
| Usgaonkar, NG | 1 |
| Elizabeth, KE | 1 |
| Kihara, T | 1 |
| Umesue, I | 1 |
| Ono, N | 1 |
| Soeda, S | 1 |
| Shimeno, H | 1 |
| Chandra, J | 1 |
| Bhatnagar, SK | 1 |
| Similä, S | 2 |
| Kouvalainen, K | 2 |
| Keinänen, S | 2 |
| Kurosawa, S | 1 |
| Kobune, F | 1 |
| Okuyama, K | 1 |
| Sugiura, A | 1 |
| Debowy, J | 3 |
| Obmińska-Domoradzka, B | 3 |
| Switała, M | 3 |
| Garbuliński, T | 3 |
| Singh, GR | 1 |
| Choudhury, P | 1 |
| Porro, A | 1 |
| Marazzi-Uberti, E | 1 |
| Lumachi, B | 1 |
| Gaetani, M | 1 |
| Coppi, G | 1 |
| Bianchi, C | 1 |
| Cashin, CH | 1 |
| Heading, CE | 1 |
| Nissen, G | 1 |
| Teubner, W | 1 |
2 reviews available for mefenamic acid and Fever
| Article | Year |
|---|---|
Antipyretics in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Child; Cyclooxygenase Inhibitors; Fever; Humans; I | 2002 |
Mefenamic acid.
Topics: Arthritis, Juvenile; Child; Fever; Humans; Mefenamic Acid | 1989 |
2 trials available for mefenamic acid and Fever
| Article | Year |
|---|---|
Choice of antipyretic in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres | 1995 |
[Antipyretic activity of mefenamic acid. Double-blind clinical studies in comparison with amidopyrine and a placebo].
Topics: Adolescent; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Tolerance | 1971 |
16 other studies available for mefenamic acid and Fever
| Article | Year |
|---|---|
Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics.
Topics: Allergens; Analgesics; Animals; Antipyretics; Body Temperature; Drug Design; Fever; Guinea Pigs; Hyp | 2010 |
50 Years Ago in The Journal of Pediatrics: Mefenamic Acid: An Antipyretic for Use in Children.
Topics: Antipyretics; Child; Fever; History, 20th Century; Humans; Mefenamic Acid | 2018 |
Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs.
Topics: Abdominal Pain; Acetaminophen; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Child; Deh | 2009 |
Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study.
Topics: Animals; Body Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interac | 2005 |
A new antipyretic agent.
Topics: Analgesics; Anti-Inflammatory Agents; Child; Child, Preschool; Fever; Humans; Mefenamic Acid; ortho- | 1967 |
Antipyretic therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Fever; Humans; Infant; Mefenamic A | 1997 |
Effect of interleukin 1 beta-induced fever on hepatic drug metabolism in rat.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cerebral Ventricles; Cytochrome P-450 Enzym | 1998 |
Oral antipyretic therapy. Evaluation of mefenamic acid (short communication).
Topics: Acetaminophen; Adolescent; Aminopyrine; Aspirin; Child; Child, Preschool; Drug Evaluation; Fever; Hu | 1977 |
Oral antipyretic therapy: evaluation of the N-aryl-anthranilic acid derivatives mefenamic acid, tolfenamic acid and flufenamic acid.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Fever; Flufenamic Aci | 1978 |
Effects of antipyretics in rinderpest virus infection in rabbits.
Topics: Animals; Antibodies, Viral; Aspirin; Female; Fever; Interferons; Lymph Nodes; Lymphoid Tissue; Male; | 1987 |
Influence of nonsteroid anti-inflammatory drugs on lymphocyte subpopulation and on the primary humoral response in normothermic and feverish rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Dose-Response Relatio | 1989 |
Inhibition of postpyrogenic increase of phagocytic and killing activity of neutrophils by nonsteroid antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Fever; | 1988 |
Migration of isolated rabbit lymphocytes in the course of pharmacological inhibition of pyrogenic fever.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cell Movement; Escherichia coli; Fever; Indomethacin; In | 1985 |
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 7. Pharmacological comparison with standard anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Edema; Female; Fever; Flufenamic Acid; Indometh | 1972 |
The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Biological Assay; Body Temperature; Cerebra | 1968 |
[Clinical experience with a new antipyretic in children].
Topics: Adolescent; Analgesics; Anti-Inflammatory Agents; Child; Child, Preschool; Fever; Humans; Mefenamic | 1968 |