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mefenamic acid and Fever

mefenamic acid has been researched along with Fever in 20 studies

Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"We studied the interaction of S-methylisothiourea (a selective inducible nitric oxide synthase inhibitor) with rofecoxib (selective cyclooxygenase-2 inhibitor) and mefenamic acid (non-selective cyclooxygenase inhibitor) in Brewer's yeast-induced pyrexia in mice by isobolographic analysis."3.73Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study. ( Bhat, AS; Krishna, V; Kumar, D; Prakash, VR; Tandan, SK, 2005)
"Administration of acetylsalicylic acid or mefenamic acid during experimental infection of rabbits with a rabbit-adapted strain of rinderpest virus did not prevent initiation of the febrile response but significantly reduced the duration of fever."3.67Effects of antipyretics in rinderpest virus infection in rabbits. ( Kobune, F; Kurosawa, S; Okuyama, K; Sugiura, A, 1987)
"Acetylsalicylic acid (300 mg/kg), mefenamic acid (30 mg/kg) or indomethacin (20 mg/kg) given orally in the doses preventing the postpyrogenic fever, inhibited the stimulatory effect of LPS on phagocytic and killing activity of neutrophils."3.67Inhibition of postpyrogenic increase of phagocytic and killing activity of neutrophils by nonsteroid antiinflammatory drugs. ( Debowy, J; Garbuliński, T; Obmińska-Domoradzka, B; Switała, M, 1988)
"The antipyretic activity of three N-aryl-anthranilic acid derivatives, mefenamic acid, tolfenamic acid and flufenamic acid, was compared and their optimal antipyretic dose determined in a trial in 87 children (aged 5 months to 15 years), who suffered from infections and fever exceeding 38."3.66Oral antipyretic therapy: evaluation of the N-aryl-anthranilic acid derivatives mefenamic acid, tolfenamic acid and flufenamic acid. ( Keinänen, S; Kouvalainen, K; Similä, S, 1978)
"The capacity of N-(2,3-xylyl)anthranilic acid (mefenamic acid) to reduce fever in children was compared with that of acetylsalicylic acid, paracetamol and amino-phenazone."3.65Oral antipyretic therapy. Evaluation of mefenamic acid (short communication). ( Keinänen, S; Kouvalainen, K; Similä, S, 1977)
"Fever is an important symptom of underlying disease condition and in general is considered harmful in pediatric age group as it may lead to febrile seizures, stupor, dehydration increase work of breathing, discomfort and tachycardia."2.41Antipyretics in children. ( Bhatnagar, SK; Chandra, J, 2002)
"Acute renal failure is commonly seen in adults after treatment with analgesic agents."1.35Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs. ( Baskin, E; Bayrakci, US; Cengiz, N; Erçoban, HS; Melek, E; Onay, OS, 2009)
"The CYP content in the mefenamic acid-treated fevered rat was also lower than that in the control."1.30Effect of interleukin 1 beta-induced fever on hepatic drug metabolism in rat. ( Kihara, T; Ono, N; Shigematsu, H; Shimeno, H; Soeda, S; Toda, A; Umesue, I, 1998)
"Fever was induced by intravenous injection of lipopolysaccharide (LPS) of E."1.28Influence of nonsteroid anti-inflammatory drugs on lymphocyte subpopulation and on the primary humoral response in normothermic and feverish rabbits. ( Debowy, J; Garbuliński, T; Obmińska-Domoradzka, B; Switała, M, 1989)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199012 (60.00)18.7374
1990's3 (15.00)18.2507
2000's3 (15.00)29.6817
2010's2 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Uramaru, N1
Shigematsu, H2
Toda, A2
Eyanagi, R1
Kitamura, S1
Ohta, S1
Dewan, P1
Gupta, P1
Onay, OS1
Erçoban, HS1
Bayrakci, US1
Melek, E1
Cengiz, N1
Baskin, E1
Bhat, AS1
Tandan, SK1
Kumar, D1
Krishna, V1
Prakash, VR1
Weiss, CF1
Harris, ST1
Khubchandani, RP1
Ghatikar, KN1
Keny, S1
Usgaonkar, NG1
Elizabeth, KE1
Kihara, T1
Umesue, I1
Ono, N1
Soeda, S1
Shimeno, H1
Chandra, J1
Bhatnagar, SK1
Similä, S2
Kouvalainen, K2
Keinänen, S2
Kurosawa, S1
Kobune, F1
Okuyama, K1
Sugiura, A1
Debowy, J3
Obmińska-Domoradzka, B3
Switała, M3
Garbuliński, T3
Singh, GR1
Choudhury, P1
Porro, A1
Marazzi-Uberti, E1
Lumachi, B1
Gaetani, M1
Coppi, G1
Bianchi, C1
Cashin, CH1
Heading, CE1
Nissen, G1
Teubner, W1

Reviews

2 reviews available for mefenamic acid and Fever

ArticleYear
Antipyretics in children.
    Indian journal of pediatrics, 2002, Volume: 69, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Child; Cyclooxygenase Inhibitors; Fever; Humans; I

2002
Mefenamic acid.
    Indian pediatrics, 1989, Volume: 26, Issue:6

    Topics: Arthritis, Juvenile; Child; Fever; Humans; Mefenamic Acid

1989

Trials

2 trials available for mefenamic acid and Fever

ArticleYear
Choice of antipyretic in children.
    The Journal of the Association of Physicians of India, 1995, Volume: 43, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

1995
[Antipyretic activity of mefenamic acid. Double-blind clinical studies in comparison with amidopyrine and a placebo].
    Minerva medica, 1971, Oct-20, Volume: 62, Issue:79

    Topics: Adolescent; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Tolerance

1971

Other Studies

16 other studies available for mefenamic acid and Fever

ArticleYear
Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics.
    Journal of medicinal chemistry, 2010, Dec-23, Volume: 53, Issue:24

    Topics: Allergens; Analgesics; Animals; Antipyretics; Body Temperature; Drug Design; Fever; Guinea Pigs; Hyp

2010
50 Years Ago in The Journal of Pediatrics: Mefenamic Acid: An Antipyretic for Use in Children.
    The Journal of pediatrics, 2018, Volume: 198

    Topics: Antipyretics; Child; Fever; History, 20th Century; Humans; Mefenamic Acid

2018
Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs.
    Pediatric emergency care, 2009, Volume: 25, Issue:4

    Topics: Abdominal Pain; Acetaminophen; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Child; Deh

2009
Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study.
    European journal of pharmacology, 2005, Mar-28, Volume: 511, Issue:2-3

    Topics: Animals; Body Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interac

2005
A new antipyretic agent.
    Michigan medicine, 1967, Volume: 66, Issue:21

    Topics: Analgesics; Anti-Inflammatory Agents; Child; Child, Preschool; Fever; Humans; Mefenamic Acid; ortho-

1967
Antipyretic therapy.
    Indian pediatrics, 1997, Volume: 34, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Fever; Humans; Infant; Mefenamic A

1997
Effect of interleukin 1 beta-induced fever on hepatic drug metabolism in rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1998, Volume: 28, Issue:6

    Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cerebral Ventricles; Cytochrome P-450 Enzym

1998
Oral antipyretic therapy. Evaluation of mefenamic acid (short communication).
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:3

    Topics: Acetaminophen; Adolescent; Aminopyrine; Aspirin; Child; Child, Preschool; Drug Evaluation; Fever; Hu

1977
Oral antipyretic therapy: evaluation of the N-aryl-anthranilic acid derivatives mefenamic acid, tolfenamic acid and flufenamic acid.
    European journal of clinical pharmacology, 1978, Jul-30, Volume: 13, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Fever; Flufenamic Aci

1978
Effects of antipyretics in rinderpest virus infection in rabbits.
    The Journal of infectious diseases, 1987, Volume: 155, Issue:5

    Topics: Animals; Antibodies, Viral; Aspirin; Female; Fever; Interferons; Lymph Nodes; Lymphoid Tissue; Male;

1987
Influence of nonsteroid anti-inflammatory drugs on lymphocyte subpopulation and on the primary humoral response in normothermic and feverish rabbits.
    Archivum immunologiae et therapiae experimentalis, 1989, Volume: 37, Issue:5-6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Dose-Response Relatio

1989
Inhibition of postpyrogenic increase of phagocytic and killing activity of neutrophils by nonsteroid antiinflammatory drugs.
    Archivum immunologiae et therapiae experimentalis, 1988, Volume: 36, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Fever;

1988
Migration of isolated rabbit lymphocytes in the course of pharmacological inhibition of pyrogenic fever.
    Archivum immunologiae et therapiae experimentalis, 1985, Volume: 33, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cell Movement; Escherichia coli; Fever; Indomethacin; In

1985
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 7. Pharmacological comparison with standard anti-inflammatory drugs.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Edema; Female; Fever; Flufenamic Acid; Indometh

1972
The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins.
    British journal of pharmacology, 1968, Volume: 34, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Biological Assay; Body Temperature; Cerebra

1968
[Clinical experience with a new antipyretic in children].
    Monatsschrift fur Kinderheilkunde, 1968, Volume: 116, Issue:3

    Topics: Adolescent; Analgesics; Anti-Inflammatory Agents; Child; Child, Preschool; Fever; Humans; Mefenamic

1968