mefenamic acid has been researched along with Edema in 43 studies
Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Enhanced analgesic and anti-inflammatory activity was observed with S-SMEDD formulations in acetic acid-induced writhings and carrageenan-induced paw edema models, respectively." | 3.91 | Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile. ( Bedi, N; Kumar, M; Singh, D, 2019) |
| "A series of new tetrasubstituted thiophenes (4a-4i, 5a-5i and 6a-6f) have been synthesized as novel anti-inflammatory agents and were evaluated for their anti-inflammatory activity in carrageenin-induced rat hind paw oedema model at the doses of 10, 20 and 40mg/kg body weight." | 3.74 | Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents. ( Haque, N; Molvi, KI; Sudarsanam, V; Vasu, KK; Yerande, SG, 2007) |
| " In a second case report we describe, in a 61-year-old patient suffering from aspirin-sensitive asthma, recurrent ciliary body oedema with a marked spastic component which was triggered by the medications acetazolamide, dipivefrine and pilocarpine." | 3.69 | Drug-induced ciliary body oedema: a new theory. ( Krieg, PH; Schipper, I, 1996) |
| "Mefenamic acid (MA) is a BCS II class NSAID drug." | 1.40 | Nano-proniosomes enhancing the transdermal delivery of mefenamic acid. ( Farid, RM; Kassem, AA; Wen, MM, 2014) |
| " These findings suggest that the prodrugs 3a and 3b synthesized might be used as biolabile prodrugs of mefenamic acid with increased bioavailability and less gastrointestinal side effects." | 1.33 | Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid. ( Akhter, M; Khan, MS, 2005) |
| " At a dosage of 100mg/kg mouse, the triterpene mixture exhibited 51% analgesic activity but only showed 20% anti-inflammatory activity." | 1.32 | Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves. ( Canlas, AP; Faustino, KM; Plana, KG; Villaseñor, IM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (69.77) | 18.7374 |
| 1990's | 1 (2.33) | 18.2507 |
| 2000's | 4 (9.30) | 29.6817 |
| 2010's | 7 (16.28) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Molvi, KI | 1 |
| Vasu, KK | 1 |
| Yerande, SG | 1 |
| Sudarsanam, V | 1 |
| Haque, N | 1 |
| Theodosis-Nobelos, P | 2 |
| Kourti, M | 2 |
| Tziona, P | 1 |
| Kourounakis, PN | 1 |
| Rekka, EA | 2 |
| Gavalas, A | 1 |
| Ayoub, R | 1 |
| Jarrar, Q | 1 |
| Ali, D | 1 |
| Moshawih, S | 1 |
| Jarrar, Y | 1 |
| Hakim, M | 1 |
| Zakaria, Z | 1 |
| Kumar, M | 1 |
| Singh, D | 1 |
| Bedi, N | 1 |
| Wen, MM | 1 |
| Farid, RM | 1 |
| Kassem, AA | 1 |
| Cunha, VR | 1 |
| Guilherme, VA | 1 |
| de Paula, E | 1 |
| de Araujo, DR | 1 |
| Silva, RO | 1 |
| Medeiros, JV | 1 |
| Leite, JR | 1 |
| Petersen, PA | 1 |
| Foldvari, M | 1 |
| Petrilli, HM | 1 |
| Constantino, VR | 1 |
| Rasheed, A | 1 |
| Ashok Kumar, CK | 1 |
| Hegazy, GH | 1 |
| Ali, HI | 1 |
| Villaseñor, IM | 2 |
| Angelada, J | 1 |
| Canlas, AP | 2 |
| Echegoyen, D | 1 |
| Faustino, KM | 1 |
| Plana, KG | 1 |
| Khan, MS | 1 |
| Akhter, M | 1 |
| Starr, MS | 1 |
| West, GB | 1 |
| Krieg, PH | 1 |
| Schipper, I | 1 |
| Ziel, R | 1 |
| Krupp, P | 1 |
| Fregnan, GB | 1 |
| Subissi, A | 1 |
| Torsello, AL | 1 |
| Bhattacharya, SK | 1 |
| Rao, PJ | 1 |
| Das Gupta, G | 1 |
| Aizawa, Y | 1 |
| Iwasaki, M | 1 |
| Domenjoz, R | 1 |
| Mörsdorf, K | 1 |
| Anspach, K | 1 |
| Kawai, K | 1 |
| Kuzuna, S | 1 |
| Morimoto, S | 1 |
| Ishii, H | 1 |
| Matsumoto, N | 1 |
| Flower, R | 1 |
| Gryglewski, R | 1 |
| Herbaczyńska-Cedro, K | 1 |
| Vane, JR | 1 |
| Tsurumi, K | 4 |
| Nozaki, M | 3 |
| Hayashi, M | 4 |
| Yamaguchi, A | 2 |
| Hiramatsu, Y | 3 |
| Komatsu, T | 1 |
| Awata, H | 2 |
| Sakai, Y | 1 |
| Inukai, T | 1 |
| Yamamoto, M | 2 |
| Inaba, S | 2 |
| Yamamoto, H | 2 |
| Fujimura, H | 1 |
| Nakano, K | 1 |
| Saito, C | 1 |
| Shibuya, T | 2 |
| Kaump, DH | 1 |
| Wagner-Jauregg, T | 1 |
| Fischer, J | 1 |
| Jahn, U | 2 |
| Kametani, T | 1 |
| Kigasawa, K | 1 |
| Hiiragi, M | 1 |
| Ishimaru, H | 1 |
| Saito, S | 1 |
| Marazzi-Uberti, E | 1 |
| Lumachi, B | 1 |
| Gaetani, M | 1 |
| Coppi, G | 1 |
| Bianchi, C | 1 |
| Arrigoni-Martelli, E | 1 |
| Schiatti, P | 1 |
| Selva, D | 1 |
| Roszkowski, AP | 1 |
| Rooks, WH | 1 |
| Tomolonis, AJ | 1 |
| Miller, LM | 1 |
| Di Rosa, M | 1 |
| Papadimitriou, JM | 1 |
| Willoughby, DA | 1 |
| Steinhäuser, E | 1 |
| Nakamura, H | 2 |
| Nakamura, K | 2 |
| Kadokawa, T | 1 |
| Nakatsuji, K | 1 |
| Nakanishi, M | 1 |
| Imamura, H | 1 |
| Maruyama, Y | 1 |
| Picciola, G | 1 |
| Gaggi, R | 1 |
| Caliari, W | 1 |
| Shanahan, RW | 1 |
| Adrian, RW | 1 |
1 trial available for mefenamic acid and Edema
| Article | Year |
|---|---|
[The use of Ponstan in pain and inflammatory conditions following dental surgery].
Topics: Aminopyrine; Anti-Inflammatory Agents; Edema; Humans; Mefenamic Acid; ortho-Aminobenzoates; Pain; Su | 1970 |
42 other studies available for mefenamic acid and Edema
| Article | Year |
|---|---|
Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship | 2007 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine ma | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hype | 2016 |
Synthesis of Novel Esters of Mefenamic Acid with Pronounced Anti-nociceptive Effects and a Proposed Activity on GABA
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Edema; Esters; gamma-Aminobutyric | 2021 |
Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avai | 2019 |
Nano-proniosomes enhancing the transdermal delivery of mefenamic acid.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dermatologic Agents; Dr | 2014 |
Delivery system for mefenamic acid based on the nanocarrier layered double hydroxide: Physicochemical characterization and evaluation of anti-inflammatory and antinociceptive potential.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Drug Carriers; Edema; | 2016 |
Tyrosine and glycine derivatives as potential prodrugs: design, synthesis, and pharmacological evaluation of amide derivatives of mefenamic acid.
Topics: Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Ede | 2010 |
Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Ibupr | 2012 |
Bioactivity studies on beta-sitosterol and its glucoside.
Topics: Acetic Acid; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Ascaris suum; Drug Evalua | 2002 |
Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2004 |
Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Carrageenan; Chromatograp | 2005 |
Discussion on the pharmacology of the fenamates.
Topics: Abnormalities, Drug-Induced; Analgesia; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; As | 1966 |
Bradykinin and oedema formation in heated paws of rats.
Topics: Animals; Aspirin; Bradykinin; Edema; Flufenamic Acid; Guinea Pigs; Histamine Release; Hot Temperatur | 1967 |
Drug-induced ciliary body oedema: a new theory.
Topics: Acetazolamide; Adult; Asthma; Chlorthalidone; Ciliary Body; Diuretics; Edema; Epinephrine; Female; H | 1996 |
The significance of inhibition of prostaglandin synthesis in the selection of non-steroidal anti-inflammatory agents.
Topics: Analgesia; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Cyclooxygenase Inhibitors; | 1975 |
Biological properties of a new non-steroidal anti-inflammatory drug: etoclofene.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Edema; Female; Guinea Pigs; Indom | 1975 |
Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan-induced paw oedema in rats.
Topics: Acetaminophen; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Hydrocortisone | 1989 |
[Relationship between the inhibition of ATPase activity and inflammatory edema by nonsteroid anti-inflammatory drugs. Approach to the screening test in vitro of nonsteroid anti-inflammatory drugs].
Topics: Acetanilides; Adenosine Triphosphatases; Aminocaproates; Aminopyrine; Aminosalicylic Acids; Animals; | 1970 |
[Pharmacology of antirheumatic drugs].
Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Central Nervous System; Chemi | 1969 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
Anti-inflammatory, analgesic and antipyretic activities of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284).
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Bronchodilator Agents; Capillary Permeabil | 1971 |
Effects of anti-inflammatory drugs on prostaglandin biosynthesis.
Topics: Acetaminophen; Aldosterone; Animals; Anti-Inflammatory Agents; Aspirin; Azathioprine; Benzoates; Bio | 1972 |
[Pharmacological studies on niflumic acid, with special reference to the comparison with fenametes. 1. Anti-inflammatory and analgesic actions].
Topics: Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability; | 1972 |
Novel quinazoline derivatives. I. Synthesis and preliminary pharmacological evaluation of an anti-inflammatory agent, SL-573.
Topics: Administration, Oral; Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Arthritis; Capillary | 1972 |
[Pharmacological studies on N-benzoyl-N'-phenyl-2,6-diaminobenzoic acid (F-1). 1. Anti-inflammatory action].
Topics: Adrenal Glands; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Ascorbic Acid; Aspirin; B | 1973 |
Novel quinazoline derivatives. II. A new anti-inflammatory agent, SL-512.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability; Cyclopropanes; Ede | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 1. On acute inflammation].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Electrolytes; Eryth | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 2. On subacute inflammation].
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Body Weight; Ed | 1973 |
Experimental observations on flufenamic, mefanamic and meclofenamic acids. II. Toxicology in animals.
Topics: Aluminum; Animals; Anti-Inflammatory Agents; Calcium; Colon; Dogs; Edema; Female; Flufenamic Acid; F | 1966 |
[Cytostatic antiphlogistics. II. Antimicrobial activity range and comparison in the Oedipus test].
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agen | 1970 |
[Syntheses of analgesics. XXIX. Synthesis and pharmacological activity of N-(2-aminoethyl)-2-indanamine derivatives].
Topics: Analgesics; Animals; Edema; Ethylamines; Indenes; Male; Mefenamic Acid; Rats | 1972 |
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 7. Pharmacological comparison with standard anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Edema; Female; Fever; Flufenamic Acid; Indometh | 1972 |
The influence of anti-inflammatory and immunosuppressant drugs on Nystatin induced oedema.
Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Ch | 1971 |
Anti-inflammatory and analgetic properties of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen).
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Fe | 1971 |
A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Carrageenan; Edema; Indomethacin; Leukocyte | 1971 |
[Effects of some anti-inflammatory agents on scald oedema].
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Cortisone; Depression, Chemical; Edema; Hindlimb; Ho | 1969 |
Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity.
Topics: Aminopyrine; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Capill | 1970 |
Pharmacological investigations of 2-amino-3-ethoxy-carbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine.
Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Bradykinin; C | 1970 |
[Synthesis and pharmacologic property of anthranilic acid-N-(aryl-substitutes)].
Topics: Animals; Anti-Inflammatory Agents; Chromatography, Paper; Edema; Formaldehyde; Granuloma; Male; Mefe | 1968 |
Local activity of anti-inflammatory and irritant agents on rat paw edema induced by carrageenin.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Dexamethasone; Edema; Formaldehyde; Hydr | 1968 |
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine].
Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo | 1969 |