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mefenamic acid and Edema

mefenamic acid has been researched along with Edema in 43 studies

Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
" Enhanced analgesic and anti-inflammatory activity was observed with S-SMEDD formulations in acetic acid-induced writhings and carrageenan-induced paw edema models, respectively."3.91Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile. ( Bedi, N; Kumar, M; Singh, D, 2019)
"A series of new tetrasubstituted thiophenes (4a-4i, 5a-5i and 6a-6f) have been synthesized as novel anti-inflammatory agents and were evaluated for their anti-inflammatory activity in carrageenin-induced rat hind paw oedema model at the doses of 10, 20 and 40mg/kg body weight."3.74Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents. ( Haque, N; Molvi, KI; Sudarsanam, V; Vasu, KK; Yerande, SG, 2007)
" In a second case report we describe, in a 61-year-old patient suffering from aspirin-sensitive asthma, recurrent ciliary body oedema with a marked spastic component which was triggered by the medications acetazolamide, dipivefrine and pilocarpine."3.69Drug-induced ciliary body oedema: a new theory. ( Krieg, PH; Schipper, I, 1996)
"Mefenamic acid (MA) is a BCS II class NSAID drug."1.40Nano-proniosomes enhancing the transdermal delivery of mefenamic acid. ( Farid, RM; Kassem, AA; Wen, MM, 2014)
" These findings suggest that the prodrugs 3a and 3b synthesized might be used as biolabile prodrugs of mefenamic acid with increased bioavailability and less gastrointestinal side effects."1.33Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid. ( Akhter, M; Khan, MS, 2005)
" At a dosage of 100mg/kg mouse, the triterpene mixture exhibited 51% analgesic activity but only showed 20% anti-inflammatory activity."1.32Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves. ( Canlas, AP; Faustino, KM; Plana, KG; Villaseñor, IM, 2004)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199030 (69.77)18.7374
1990's1 (2.33)18.2507
2000's4 (9.30)29.6817
2010's7 (16.28)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Molvi, KI1
Vasu, KK1
Yerande, SG1
Sudarsanam, V1
Haque, N1
Theodosis-Nobelos, P2
Kourti, M2
Tziona, P1
Kourounakis, PN1
Rekka, EA2
Gavalas, A1
Ayoub, R1
Jarrar, Q1
Ali, D1
Moshawih, S1
Jarrar, Y1
Hakim, M1
Zakaria, Z1
Kumar, M1
Singh, D1
Bedi, N1
Wen, MM1
Farid, RM1
Kassem, AA1
Cunha, VR1
Guilherme, VA1
de Paula, E1
de Araujo, DR1
Silva, RO1
Medeiros, JV1
Leite, JR1
Petersen, PA1
Foldvari, M1
Petrilli, HM1
Constantino, VR1
Rasheed, A1
Ashok Kumar, CK1
Hegazy, GH1
Ali, HI1
Villaseñor, IM2
Angelada, J1
Canlas, AP2
Echegoyen, D1
Faustino, KM1
Plana, KG1
Khan, MS1
Akhter, M1
Starr, MS1
West, GB1
Krieg, PH1
Schipper, I1
Ziel, R1
Krupp, P1
Fregnan, GB1
Subissi, A1
Torsello, AL1
Bhattacharya, SK1
Rao, PJ1
Das Gupta, G1
Aizawa, Y1
Iwasaki, M1
Domenjoz, R1
Mörsdorf, K1
Anspach, K1
Kawai, K1
Kuzuna, S1
Morimoto, S1
Ishii, H1
Matsumoto, N1
Flower, R1
Gryglewski, R1
Herbaczyńska-Cedro, K1
Vane, JR1
Tsurumi, K4
Nozaki, M3
Hayashi, M4
Yamaguchi, A2
Hiramatsu, Y3
Komatsu, T1
Awata, H2
Sakai, Y1
Inukai, T1
Yamamoto, M2
Inaba, S2
Yamamoto, H2
Fujimura, H1
Nakano, K1
Saito, C1
Shibuya, T2
Kaump, DH1
Wagner-Jauregg, T1
Fischer, J1
Jahn, U2
Kametani, T1
Kigasawa, K1
Hiiragi, M1
Ishimaru, H1
Saito, S1
Marazzi-Uberti, E1
Lumachi, B1
Gaetani, M1
Coppi, G1
Bianchi, C1
Arrigoni-Martelli, E1
Schiatti, P1
Selva, D1
Roszkowski, AP1
Rooks, WH1
Tomolonis, AJ1
Miller, LM1
Di Rosa, M1
Papadimitriou, JM1
Willoughby, DA1
Steinhäuser, E1
Nakamura, H2
Nakamura, K2
Kadokawa, T1
Nakatsuji, K1
Nakanishi, M1
Imamura, H1
Maruyama, Y1
Picciola, G1
Gaggi, R1
Caliari, W1
Shanahan, RW1
Adrian, RW1

Trials

1 trial available for mefenamic acid and Edema

ArticleYear
[The use of Ponstan in pain and inflammatory conditions following dental surgery].
    Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie, 1970, Volume: 80, Issue:4

    Topics: Aminopyrine; Anti-Inflammatory Agents; Edema; Humans; Mefenamic Acid; ortho-Aminobenzoates; Pain; Su

1970

Other Studies

42 other studies available for mefenamic acid and Edema

ArticleYear
Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship

2007
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
    Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine ma

2015
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
    Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3

    Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hype

2016
Synthesis of Novel Esters of Mefenamic Acid with Pronounced Anti-nociceptive Effects and a Proposed Activity on GABA
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2021, Aug-01, Volume: 163

    Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Edema; Esters; gamma-Aminobutyric

2021
Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile.
    Therapeutic delivery, 2019, Volume: 10, Issue:1

    Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avai

2019
Nano-proniosomes enhancing the transdermal delivery of mefenamic acid.
    Journal of liposome research, 2014, Volume: 24, Issue:4

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dermatologic Agents; Dr

2014
Delivery system for mefenamic acid based on the nanocarrier layered double hydroxide: Physicochemical characterization and evaluation of anti-inflammatory and antinociceptive potential.
    Materials science & engineering. C, Materials for biological applications, 2016, Jan-01, Volume: 58

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Drug Carriers; Edema;

2016
Tyrosine and glycine derivatives as potential prodrugs: design, synthesis, and pharmacological evaluation of amide derivatives of mefenamic acid.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:6

    Topics: Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Ede

2010
Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.
    Bioorganic & medicinal chemistry, 2012, Feb-01, Volume: 20, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Ibupr

2012
Bioactivity studies on beta-sitosterol and its glucoside.
    Phytotherapy research : PTR, 2002, Volume: 16, Issue:5

    Topics: Acetic Acid; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Ascaris suum; Drug Evalua

2002
Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves.
    Journal of ethnopharmacology, 2004, Volume: 92, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; An

2004
Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid.
    Die Pharmazie, 2005, Volume: 60, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Carrageenan; Chromatograp

2005
Discussion on the pharmacology of the fenamates.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Abnormalities, Drug-Induced; Analgesia; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; As

1966
Bradykinin and oedema formation in heated paws of rats.
    British journal of pharmacology and chemotherapy, 1967, Volume: 31, Issue:1

    Topics: Animals; Aspirin; Bradykinin; Edema; Flufenamic Acid; Guinea Pigs; Histamine Release; Hot Temperatur

1967
Drug-induced ciliary body oedema: a new theory.
    Eye (London, England), 1996, Volume: 10 ( Pt 1)

    Topics: Acetazolamide; Adult; Asthma; Chlorthalidone; Ciliary Body; Diuretics; Edema; Epinephrine; Female; H

1996
The significance of inhibition of prostaglandin synthesis in the selection of non-steroidal anti-inflammatory agents.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2

    Topics: Analgesia; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Cyclooxygenase Inhibitors;

1975
Biological properties of a new non-steroidal anti-inflammatory drug: etoclofene.
    Il Farmaco; edizione scientifica, 1975, Volume: 30, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Edema; Female; Guinea Pigs; Indom

1975
Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan-induced paw oedema in rats.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:8

    Topics: Acetaminophen; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Hydrocortisone

1989
[Relationship between the inhibition of ATPase activity and inflammatory edema by nonsteroid anti-inflammatory drugs. Approach to the screening test in vitro of nonsteroid anti-inflammatory drugs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Jul-20, Volume: 66, Issue:4

    Topics: Acetanilides; Adenosine Triphosphatases; Aminocaproates; Aminopyrine; Aminosalicylic Acids; Animals;

1970
[Pharmacology of antirheumatic drugs].
    Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1969, Volume: 1

    Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Central Nervous System; Chemi

1969
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 192, Issue:1

    Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D

1971
Anti-inflammatory, analgesic and antipyretic activities of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284).
    Japanese journal of pharmacology, 1971, Volume: 21, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Bronchodilator Agents; Capillary Permeabil

1971
Effects of anti-inflammatory drugs on prostaglandin biosynthesis.
    Nature: New biology, 1972, Jul-26, Volume: 238, Issue:82

    Topics: Acetaminophen; Aldosterone; Animals; Anti-Inflammatory Agents; Aspirin; Azathioprine; Benzoates; Bio

1972
[Pharmacological studies on niflumic acid, with special reference to the comparison with fenametes. 1. Anti-inflammatory and analgesic actions].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:6

    Topics: Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability;

1972
Novel quinazoline derivatives. I. Synthesis and preliminary pharmacological evaluation of an anti-inflammatory agent, SL-573.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:11

    Topics: Administration, Oral; Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Arthritis; Capillary

1972
[Pharmacological studies on N-benzoyl-N'-phenyl-2,6-diaminobenzoic acid (F-1). 1. Anti-inflammatory action].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5

    Topics: Adrenal Glands; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Ascorbic Acid; Aspirin; B

1973
Novel quinazoline derivatives. II. A new anti-inflammatory agent, SL-512.
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability; Cyclopropanes; Ede

1973
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 1. On acute inflammation].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:2

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Electrolytes; Eryth

1973
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 2. On subacute inflammation].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:2

    Topics: Acute Disease; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Body Weight; Ed

1973
Experimental observations on flufenamic, mefanamic and meclofenamic acids. II. Toxicology in animals.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Aluminum; Animals; Anti-Inflammatory Agents; Calcium; Colon; Dogs; Edema; Female; Flufenamic Acid; F

1966
[Cytostatic antiphlogistics. II. Antimicrobial activity range and comparison in the Oedipus test].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agen

1970
[Syntheses of analgesics. XXIX. Synthesis and pharmacological activity of N-(2-aminoethyl)-2-indanamine derivatives].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:4

    Topics: Analgesics; Animals; Edema; Ethylamines; Indenes; Male; Mefenamic Acid; Rats

1972
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 7. Pharmacological comparison with standard anti-inflammatory drugs.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Edema; Female; Fever; Flufenamic Acid; Indometh

1972
The influence of anti-inflammatory and immunosuppressant drugs on Nystatin induced oedema.
    Pharmacology, 1971, Volume: 5, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Ch

1971
Anti-inflammatory and analgetic properties of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen).
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 179, Issue:1

    Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Fe

1971
A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs.
    The Journal of pathology, 1971, Volume: 105, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Carrageenan; Edema; Indomethacin; Leukocyte

1971
[Effects of some anti-inflammatory agents on scald oedema].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1969, May-20, Volume: 65, Issue:3

    Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Cortisone; Depression, Chemical; Edema; Hindlimb; Ho

1969
Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:8

    Topics: Aminopyrine; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Capill

1970
Pharmacological investigations of 2-amino-3-ethoxy-carbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:8

    Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Bradykinin; C

1970
[Synthesis and pharmacologic property of anthranilic acid-N-(aryl-substitutes)].
    Il Farmaco; edizione scientifica, 1968, Volume: 23, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Chromatography, Paper; Edema; Formaldehyde; Granuloma; Male; Mefe

1968
Local activity of anti-inflammatory and irritant agents on rat paw edema induced by carrageenin.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 175, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Dexamethasone; Edema; Formaldehyde; Hydr

1968
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:1

    Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo

1969