mefenamic acid has been researched along with Ductus Arteriosus, Patent in 6 studies
Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Ductus Arteriosus, Patent: A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There were marked inter-individual differences in some of the pharmacokinetic parameters after the first dose; peak plasma concentration (Cmax) varied from 1." | 1.29 | Pharmacokinetics of mefenamic acid in preterm infants with patent ductus arteriosus. ( Ito, K; Niida, Y; Owada, E; Sato, J; Umetsu, M, 1994) |
| " We recommend the use of MA for closure of symptomatic PDA in preterms, especially in those cases where indomethacin is not tolerated or when minute titration of its dosage is impracticable." | 1.28 | Therapy of symptomatic patent ductus arteriosus in preterms using mefenemic acid and indomethacin. ( Merchant, RH; Sakhalkar, VS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ito, K | 5 |
| Niida, Y | 3 |
| Sato, J | 3 |
| Owada, E | 3 |
| Umetsu, M | 3 |
| Shimada, S | 1 |
| Kasai, T | 1 |
| Konishi, M | 1 |
| Fujiwara, T | 1 |
| Merchant, RH | 2 |
| Sakhalkar, VS | 2 |
| Kudo, N | 1 |
| Kikuta, T | 1 |
| Wakamatsu, A | 1 |
6 other studies available for mefenamic acid and Ductus Arteriosus, Patent
| Article | Year |
|---|---|
Pharmacokinetics of mefenamic acid in preterm infants with patent ductus arteriosus.
Topics: Administration, Oral; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Premature, Disease | 1994 |
Effects of patent ductus arteriosus on left ventricular output and organ blood flows in preterm infants with respiratory distress syndrome treated with surfactant.
Topics: Blood Flow Velocity; Cardiac Output; Case-Control Studies; Ductus Arteriosus, Patent; Echocardiograp | 1994 |
Patent ductus arteriosus in the newborn.
Topics: Ductus Arteriosus, Patent; Humans; Infant, Newborn; Mefenamic Acid | 1994 |
Urinary excretion of mefenamic acid and its metabolites including their esterglucuronides in preterm infants undergoing mefenamic acid therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Ductus Arteriosus, Pa | 1997 |
Therapy of symptomatic patent ductus arteriosus in preterms using mefenemic acid and indomethacin.
Topics: Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Mefen | 1992 |
Simple, rapid and sensitive reversed-phase high-performance liquid chromatographic method for the determination of mefenamic acid in plasma.
Topics: Chromatography, High Pressure Liquid; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Pr | 1989 |