Page last updated: 2024-10-30

mefenamic acid and Diaper Rash

mefenamic acid has been researched along with Diaper Rash in 1 studies

Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.

Diaper Rash: A type of irritant dermatitis localized to the area in contact with a diaper and occurring most often as a reaction to prolonged contact with urine, feces, or retained soap or detergent.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sullivan, RW1
Ryzewski, M1
Holland, MG1
Marraffa, JM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Other Studies

1 other study available for mefenamic acid and Diaper Rash

ArticleYear
Compounded ointment results in severe toxicity in a pediatric patient.
    Pediatric emergency care, 2013, Volume: 29, Issue:11

    Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M

2013